SCN4B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SCN4B
Entrez Gene ID	6330
Full Name	sodium voltage-gated channel beta subunit 4
Synonyms	ATFB17,LQT10,Navbeta4
General protein information	Preferred Names sodium voltage-gated channel beta subunit 4 Names sodium channel subunit beta-4 sodium channel, voltage-gated, type IV, beta subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q23.3
Summary	The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009].
Disorder MIM:	608256
Disorder Html:	Long QT syndrome-10, 611819 (3); Atrial fibrillation, familial, 17, 611819 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001142349.2	NP_001135821.1	sodium channel subunit beta-4 isoform 3
NM_174934.3	NP_777594.1	sodium channel subunit beta-4 isoform 1 precursor
NM_001142348.2	NP_001135820.1	sodium channel subunit beta-4 isoform 2
NM_001142349.1	NP_001135821.1	sodium channel subunit beta-4 isoform 3
NM_001142348.1	NP_001135820.1	sodium channel subunit beta-4 isoform 2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	scn4ba	NP_001071038.1
Gallus gallus (chicken)	SCN4B	XP_004948171.1
Bos taurus (cattle)	SCN4B	NP_001070380.1
Mus musculus (house mouse)	Scn4b	NP_001013408.1
Rattus norvegicus (Norway rat)	Scn4b	NP_001008880.1
Danio rerio (zebrafish)	scn4bb	NP_001071041.1
Macaca mulatta (Rhesus monkey)	LOC100430940	XP_002799948.1
Homo sapiens (human)	SCN4B	NP_777594.1
Xenopus tropicalis (tropical clawed frog)	scn4b	NP_001011311.1
Canis lupus familiaris (dog)	SCN4B	XP_005619774.1
Pan troglodytes (chimpanzee)	SCN4B	XP_001159939.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of rare variants in cardiac sodium channel β4-subunit gene SCN4B associated with ventricular tachycardia.
Yang Q, Xiong H, Xu C, Huang Y, Tu X, Wu G, Fu F, Wang Z, Wang L, Zhao Y, Li S, Huang Y, Wang C, Wang D, Yao Y, Wang F, Wang Y, Xue Y, Wang P, Chen Q, Pu J, Wang QK
Molecular genetics and genomics : MGG294(4)1059-1071(2019 Aug)

Structure of the human voltage-gated sodium channel Na
Pan X, Li Z, Zhou Q, Shen H, Wu K, Huang X, Chen J, Zhang J, Zhu X, Lei J, Xiong W, Gong H, Xiao B, Yan N
Science (New York, N.Y.)362(6412)(2018 10)

Preserved SCN4B expression is an independent indicator of favorable recurrence-free survival in classical papillary thyroid cancer.
Gong Y, Yang J, Wu W, Liu F, Su A, Li Z, Zhu J, Wei T
PloS one13(5)e0197007(2018)

Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion.
Shimizu H, Tosaki A, Ohsawa N, Ishizuka-Katsura Y, Shoji S, Miyazaki H, Oyama F, Terada T, Shirouzu M, Sekine SI, Nukina N, Yokoyama S
The Journal of biological chemistry292(32)13428-13440(2017 08)

SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer.
Bon E, Driffort V, Gradek F, Martinez-Caceres C, Anchelin M, Pelegrin P, Cayuela ML, Marionneau-Lambot S, Oullier T, Guibon R, Fromont G, Gutierrez-Pajares JL, Domingo I, Piver E, Moreau A, Burlaud-Gaillard J, Frank PG, Chevalier S, Besson P, Roger S
Nature communications713648(2016 12)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SCN4B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SCN4B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16427	NM_001142348.2 Latest version!	Homo sapiens sodium voltage-gated channel beta subunit 4 (SCN4B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu16586	NM_001142349.2 Latest version!	Homo sapiens sodium voltage-gated channel beta subunit 4 (SCN4B), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu18675	NM_174934.3 Latest version!	Homo sapiens sodium voltage-gated channel beta subunit 4 (SCN4B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$139.30 $199.00
View Old Accession Versions >>
OHu16586	NM_001142349.1	Homo sapiens sodium voltage-gated channel beta subunit 4 (SCN4B), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu16427	NM_001142348.1	Homo sapiens sodium voltage-gated channel beta subunit 4 (SCN4B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SCN4B ( NM_001142348.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001135820.1 Homo sapiens sodium voltage-gated channel beta subunit 4 (SCN4B), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16427
Clone ID Related Accession (Same CDS sequence)	NM_001142348.2 , NM_001142348.1
Accession Version	NM_001142348.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 285bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571932800000
Organism	Homo sapiens(human)
Product	sodium channel subunit beta-4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB237478.1, DA109496.1, BC035017.2, DB101246.1 and AY149967.1. On Jun 2, 2019 this sequence version replaced NM_001142348.1. Transcript Variant: This variant (2) lacks multiple in-frame exons in the 5' coding region, compared to variant 1. This variant encodes isoform 2 which has a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA318361.1, DA109496.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCGGGG CTGGGGACGG AGGCAAAGCC CCGGCGAGAT GGCTGGGCAC TGGGCTTTTG 
GTGGAAGAAG TGGACAACAC AGTGACACTC ATCATCCTGG CTGTCGTGGG CGGGGTCATC 
GGGCTCCTCA TCCTCATCCT GCTGATCAAG AAACTCATCA TCTTCATCCT GAAGAAGACT 
CGGGAGAAGA AGAAGGAGTG TCTCGTGAGC TCCTCGGGGA ATGACAACAC GGAGAACGGC 
TTGCCTGGCT CCAAGGCAGA GGAGAAACCA CCTTCAAAAG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001135820.1
CDS	151..435
Translation	MPGAGDGGKAPARWLGTGLLVEEVDNTVTLIILAVVGGVIGLLILILLIKKLIIFILKKTREKKKECLVSSSGNDNTENGLPGSKAEEKPPSKV

Target ORF information:

RefSeq Version	NM_001142348.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sodium voltage-gated channel beta subunit 4 (SCN4B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142348.2

ORF Insert Sequence:

ATGCCCGGGG CTGGGGACGG AGGCAAAGCC CCGGCGAGAT GGCTGGGCAC TGGGCTTTTG 
GTGGAAGAAG TGGACAACAC AGTGACACTC ATCATCCTGG CTGTCGTGGG CGGGGTCATC 
GGGCTCCTCA TCCTCATCCT GCTGATCAAG AAACTCATCA TCTTCATCCT GAAGAAGACT 
CGGGAGAAGA AGAAGGAGTG TCTCGTGAGC TCCTCGGGGA ATGACAACAC GGAGAACGGC 
TTGCCTGGCT CCAAGGCAGA GGAGAAACCA CCTTCAAAAG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SCN4B ( NM_001142348.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001135820.1 Homo sapiens sodium voltage-gated channel beta subunit 4 (SCN4B), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16427
Clone ID Related Accession (Same CDS sequence)	NM_001142348.2 , NM_001142348.1
Accession Version	NM_001142348.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 285bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550505600000
Organism	Homo sapiens(human)
Product	sodium channel subunit beta-4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB237478.1, DA109496.1, BC035017.2, DB101246.1 and AY149967.1. Transcript Variant: This variant (2) lacks multiple in-frame exons in the 5' coding region, compared to variant 1. This variant encodes isoform 2 which has a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA109496.1, DA109598.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCGGGG CTGGGGACGG AGGCAAAGCC CCGGCGAGAT GGCTGGGCAC TGGGCTTTTG 
GTGGAAGAAG TGGACAACAC AGTGACACTC ATCATCCTGG CTGTCGTGGG CGGGGTCATC 
GGGCTCCTCA TCCTCATCCT GCTGATCAAG AAACTCATCA TCTTCATCCT GAAGAAGACT 
CGGGAGAAGA AGAAGGAGTG TCTCGTGAGC TCCTCGGGGA ATGACAACAC GGAGAACGGC 
TTGCCTGGCT CCAAGGCAGA GGAGAAACCA CCTTCAAAAG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001135820.1
CDS	243..527
Translation	MPGAGDGGKAPARWLGTGLLVEEVDNTVTLIILAVVGGVIGLLILILLIKKLIIFILKKTREKKKECLVSSSGNDNTENGLPGSKAEEKPPSKV

Target ORF information:

RefSeq Version	NM_001142348.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sodium voltage-gated channel beta subunit 4 (SCN4B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142348.1

ORF Insert Sequence:

ATGCCCGGGG CTGGGGACGG AGGCAAAGCC CCGGCGAGAT GGCTGGGCAC TGGGCTTTTG 
GTGGAAGAAG TGGACAACAC AGTGACACTC ATCATCCTGG CTGTCGTGGG CGGGGTCATC 
GGGCTCCTCA TCCTCATCCT GCTGATCAAG AAACTCATCA TCTTCATCCT GAAGAAGACT 
CGGGAGAAGA AGAAGGAGTG TCTCGTGAGC TCCTCGGGGA ATGACAACAC GGAGAACGGC 
TTGCCTGGCT CCAAGGCAGA GGAGAAACCA CCTTCAAAAG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SCN4B ( NM_001142349.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001135821.1 Homo sapiens sodium voltage-gated channel beta subunit 4 (SCN4B), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu16586
Clone ID Related Accession (Same CDS sequence)	NM_001142349.2 , NM_001142349.1
Accession Version	NM_001142349.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 357bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571932800000
Organism	Homo sapiens(human)
Product	sodium channel subunit beta-4 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA111034.1, DA211092.1, AY149967.1, DB101246.1 and BC035017.2. On Jun 2, 2019 this sequence version replaced NM_001142349.1. Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an in-frame downstream ATG and an isoform (3) which has a shorter N-terminus, compared to isoform 1. Translation initiation from the start codon 197 nucleotides upstream would subject the transcript to nonsense-mediated mRNA decay (NMD). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035017.2, SRR1660809.103995.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2157437 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACAACA TTTCCATTGT GCTGAGGGAC CTGGAGTTCA GCGACACGGG CAAATACACC 
TGCCATGTGA AGAACCCCAA GGAGAATAAT CTCCAGCACC ACGCCACCAT CTTCCTCCAA 
GTCGTTGATA GACTGGAAGA AGTGGACAAC ACAGTGACAC TCATCATCCT GGCTGTCGTG 
GGCGGGGTCA TCGGGCTCCT CATCCTCATC CTGCTGATCA AGAAACTCAT CATCTTCATC 
CTGAAGAAGA CTCGGGAGAA GAAGAAGGAG TGTCTCGTGA GCTCCTCGGG GAATGACAAC 
ACGGAGAACG GCTTGCCTGG CTCCAAGGCA GAGGAGAAAC CACCTTCAAA AGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001135821.1
CDS	474..830
Translation	MNNISIVLRDLEFSDTGKYTCHVKNPKENNLQHHATIFLQVVDRLEEVDNTVTLIILAVVGGVIGLLILILLIKKLIIFILKKTREKKKECLVSSSGNDNTENGLPGSKAEEKPPSKV

Target ORF information:

RefSeq Version	NM_001142349.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sodium voltage-gated channel beta subunit 4 (SCN4B), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142349.2

ORF Insert Sequence:

ATGAACAACA TTTCCATTGT GCTGAGGGAC CTGGAGTTCA GCGACACGGG CAAATACACC 
TGCCATGTGA AGAACCCCAA GGAGAATAAT CTCCAGCACC ACGCCACCAT CTTCCTCCAA 
GTCGTTGATA GACTGGAAGA AGTGGACAAC ACAGTGACAC TCATCATCCT GGCTGTCGTG 
GGCGGGGTCA TCGGGCTCCT CATCCTCATC CTGCTGATCA AGAAACTCAT CATCTTCATC 
CTGAAGAAGA CTCGGGAGAA GAAGAAGGAG TGTCTCGTGA GCTCCTCGGG GAATGACAAC 
ACGGAGAACG GCTTGCCTGG CTCCAAGGCA GAGGAGAAAC CACCTTCAAA AGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SCN4B ( NM_001142349.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001135821.1 Homo sapiens sodium voltage-gated channel beta subunit 4 (SCN4B), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu16586
Clone ID Related Accession (Same CDS sequence)	NM_001142349.2 , NM_001142349.1
Accession Version	NM_001142349.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 357bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550505600000
Organism	Homo sapiens(human)
Product	sodium channel subunit beta-4 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA111034.1, DA211092.1, AY149967.1, DB101246.1 and BC035017.2. Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an in-frame downstream ATG and an isoform (3) which has a shorter N-terminus, compared to isoform 1. Translation initiation from the start codon 197 nucleotides upstream would subject the transcript to nonsense-mediated mRNA decay (NMD). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035017.2, SRR1660809.103995.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2157437 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACAACA TTTCCATTGT GCTGAGGGAC CTGGAGTTCA GCGACACGGG CAAATACACC 
TGCCATGTGA AGAACCCCAA GGAGAATAAT CTCCAGCACC ACGCCACCAT CTTCCTCCAA 
GTCGTTGATA GACTGGAAGA AGTGGACAAC ACAGTGACAC TCATCATCCT GGCTGTCGTG 
GGCGGGGTCA TCGGGCTCCT CATCCTCATC CTGCTGATCA AGAAACTCAT CATCTTCATC 
CTGAAGAAGA CTCGGGAGAA GAAGAAGGAG TGTCTCGTGA GCTCCTCGGG GAATGACAAC 
ACGGAGAACG GCTTGCCTGG CTCCAAGGCA GAGGAGAAAC CACCTTCAAA AGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001135821.1
CDS	510..866
Translation	MNNISIVLRDLEFSDTGKYTCHVKNPKENNLQHHATIFLQVVDRLEEVDNTVTLIILAVVGGVIGLLILILLIKKLIIFILKKTREKKKECLVSSSGNDNTENGLPGSKAEEKPPSKV

Target ORF information:

RefSeq Version	NM_001142349.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sodium voltage-gated channel beta subunit 4 (SCN4B), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142349.1

ORF Insert Sequence:

ATGAACAACA TTTCCATTGT GCTGAGGGAC CTGGAGTTCA GCGACACGGG CAAATACACC 
TGCCATGTGA AGAACCCCAA GGAGAATAAT CTCCAGCACC ACGCCACCAT CTTCCTCCAA 
GTCGTTGATA GACTGGAAGA AGTGGACAAC ACAGTGACAC TCATCATCCT GGCTGTCGTG 
GGCGGGGTCA TCGGGCTCCT CATCCTCATC CTGCTGATCA AGAAACTCAT CATCTTCATC 
CTGAAGAAGA CTCGGGAGAA GAAGAAGGAG TGTCTCGTGA GCTCCTCGGG GAATGACAAC 
ACGGAGAACG GCTTGCCTGG CTCCAAGGCA GAGGAGAAAC CACCTTCAAA AGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SCN4B ( NM_174934.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_777594.1 Homo sapiens sodium voltage-gated channel beta subunit 4 (SCN4B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18675
Clone ID Related Accession (Same CDS sequence)	NM_174934.3
Accession Version	NM_174934.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 687bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569600000000
Organism	Homo sapiens(human)
Product	sodium channel subunit beta-4 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB237478.1, AY149967.1, DB101246.1 and BC035017.2. This sequence is a reference standard in the RefSeqGene project. On Nov 27, 2008 this sequence version replaced NM_174934.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY149967.1, SRR1803614.46885.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2157437 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCCGGGG CTGGGGACGG AGGCAAAGCC CCGGCGAGAT GGCTGGGCAC TGGGCTTTTG 
GGCCTCTTCC TGCTCCCCGT AACCCTGTCG CTGGAGGTGT CTGTGGGAAA GGCCACCGAC 
ATCTACGCTG TCAATGGCAC GGAGATCCTG CTGCCCTGCA CCTTCTCCAG CTGCTTTGGC 
TTCGAGGACC TCCACTTCCG GTGGACCTAC AACAGCAGTG ACGCATTCAA GATTCTCATA 
GAGGGGACTG TGAAGAATGA GAAGTCTGAC CCCAAGGTGA CGTTGAAAGA CGATGACCGC 
ATCACTCTGG TAGGCTCTAC TAAGGAGAAG ATGAACAACA TTTCCATTGT GCTGAGGGAC 
CTGGAGTTCA GCGACACGGG CAAATACACC TGCCATGTGA AGAACCCCAA GGAGAATAAT 
CTCCAGCACC ACGCCACCAT CTTCCTCCAA GTCGTTGATA GACTGGAAGA AGTGGACAAC 
ACAGTGACAC TCATCATCCT GGCTGTCGTG GGCGGGGTCA TCGGGCTCCT CATCCTCATC 
CTGCTGATCA AGAAACTCAT CATCTTCATC CTGAAGAAGA CTCGGGAGAA GAAGAAGGAG 
TGTCTCGTGA GCTCCTCGGG GAATGACAAC ACGGAGAACG GCTTGCCTGG CTCCAAGGCA 
GAGGAGAAAC CACCTTCAAA AGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_777594.1
CDS	243..929
Translation	MPGAGDGGKAPARWLGTGLLGLFLLPVTLSLEVSVGKATDIYAVNGTEILLPCTFSSCFGFEDLHFRWTYNSSDAFKILIEGTVKNEKSDPKVTLKDDDRITLVGSTKEKMNNISIVLRDLEFSDTGKYTCHVKNPKENNLQHHATIFLQVVDRLEEVDNTVTLIILAVVGGVIGLLILILLIKKLIIFILKKTREKKKECLVSSSGNDNTENGLPGSKAEEKPPSKV

Target ORF information:

RefSeq Version	NM_174934.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sodium voltage-gated channel beta subunit 4 (SCN4B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174934.3

ORF Insert Sequence:

ATGCCCGGGG CTGGGGACGG AGGCAAAGCC CCGGCGAGAT GGCTGGGCAC TGGGCTTTTG 
GGCCTCTTCC TGCTCCCCGT AACCCTGTCG CTGGAGGTGT CTGTGGGAAA GGCCACCGAC 
ATCTACGCTG TCAATGGCAC GGAGATCCTG CTGCCCTGCA CCTTCTCCAG CTGCTTTGGC 
TTCGAGGACC TCCACTTCCG GTGGACCTAC AACAGCAGTG ACGCATTCAA GATTCTCATA 
GAGGGGACTG TGAAGAATGA GAAGTCTGAC CCCAAGGTGA CGTTGAAAGA CGATGACCGC 
ATCACTCTGG TAGGCTCTAC TAAGGAGAAG ATGAACAACA TTTCCATTGT GCTGAGGGAC 
CTGGAGTTCA GCGACACGGG CAAATACACC TGCCATGTGA AGAACCCCAA GGAGAATAAT 
CTCCAGCACC ACGCCACCAT CTTCCTCCAA GTCGTTGATA GACTGGAAGA AGTGGACAAC 
ACAGTGACAC TCATCATCCT GGCTGTCGTG GGCGGGGTCA TCGGGCTCCT CATCCTCATC 
CTGCTGATCA AGAAACTCAT CATCTTCATC CTGAAGAAGA CTCGGGAGAA GAAGAAGGAG 
TGTCTCGTGA GCTCCTCGGG GAATGACAAC ACGGAGAACG GCTTGCCTGG CTCCAAGGCA 
GAGGAGAAAC CACCTTCAAA AGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of rare variants in cardiac sodium channel β4-subunit gene SCN4B associated with ventricular tachycardia.
Molecular genetics and genomics : MGG294(4)1059-1071(2019 Aug)
Yang Q,Xiong H,Xu C,Huang Y,Tu X,Wu G,Fu F,Wang Z,Wang L,Zhao Y,Li S,Huang Y,Wang C,Wang D,Yao Y,Wang F,Wang Y,Xue Y,Wang P,Chen Q,Pu J,Wang QK

Structure of the human voltage-gated sodium channel Na
Science (New York, N.Y.)362(6412)(2018 10)
Pan X,Li Z,Zhou Q,Shen H,Wu K,Huang X,Chen J,Zhang J,Zhu X,Lei J,Xiong W,Gong H,Xiao B,Yan N

Preserved SCN4B expression is an independent indicator of favorable recurrence-free survival in classical papillary thyroid cancer.
PloS one13(5)e0197007(2018)
Gong Y,Yang J,Wu W,Liu F,Su A,Li Z,Zhu J,Wei T

Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion.
The Journal of biological chemistry292(32)13428-13440(2017 08)
Shimizu H,Tosaki A,Ohsawa N,Ishizuka-Katsura Y,Shoji S,Miyazaki H,Oyama F,Terada T,Shirouzu M,Sekine SI,Nukina N,Yokoyama S

SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer.
Nature communications713648(2016 12)
Bon E,Driffort V,Gradek F,Martinez-Caceres C,Anchelin M,Pelegrin P,Cayuela ML,Marionneau-Lambot S,Oullier T,Guibon R,Fromont G,Gutierrez-Pajares JL,Domingo I,Piver E,Moreau A,Burlaud-Gaillard J,Frank PG,Chevalier S,Besson P,Roger S

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SCN4B cDNA ORF clone, Homo sapiens(human)

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