BGLAP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BGLAP
Entrez Gene ID	632
Full Name	bone gamma-carboxyglutamate protein
Synonyms	BGP,OC,OCN
General protein information	Preferred Names bone gamma-carboxyglutamate protein Names osteocalcin bone gamma-carboxyglutamate (gla) protein (osteocalcin) gamma-carboxyglutamic acid-containing protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q22
Summary	This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015].
Disorder MIM:	112260

mRNA and Protein(s)

mRNA	Protein	Name
NM_199173.5	NP_954642.1	osteocalcin preproprotein
NM_199173.6	NP_954642.1	osteocalcin preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	BGLAP	NP_001129100.1
Macaca mulatta (Rhesus monkey)	BGLAP	NP_001074237.1
Mus musculus (house mouse)	Bglap2	NP_001027469.2
Bos taurus (cattle)	BGLAP	NP_776674.1
Mus musculus (house mouse)	Bglap	NP_031567.1
Mus musculus (house mouse)	Bglap3	NP_112736.3
Rattus norvegicus (Norway rat)	Bglap	NP_038200.1
Canis lupus familiaris (dog)	BGLAP	XP_547536.2
Homo sapiens (human)	BGLAP	NP_954642.1

Gene Ontology
Bibliography

Related articles in PubMed

Circulating Levels of Osteoprotegerin, Osteocalcin and Osteopontin in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.
Liu LN, Mao YM, Zhao CN, Wang H, Yuan FF, Li XM, Pan HF
Immunological investigations48(2)107-120(2019 Feb)

The Association Between Osteocalcin and Chronic Inflammation in Patients with Type 2 Diabetes Mellitus.
Kanazawa I, Tanaka S, Sugimoto T
Calcified tissue international103(6)599-605(2018 12)

Correlations between serum concentration of three bone-derived factors and obesity and visceral fat accumulation in a cohort of middle aged men and women.
Xu Y, Ma X, Pan X, He X, Xiao Y, Bao Y
Cardiovascular diabetology17(1)143(2018 11)

Serum Osteocalcin Levels in Girls with Central Precocious Puberty: Relation to the Onset of Puberty.
Lee WY, Jung G, Kim HR, Nam HK, Rhie YJ, Lee KH
The Tohoku journal of experimental medicine245(4)239-243(2018 08)

Osteocalcin HindIII gene polymorphism not associated with bone mineral density—A study in North Indian postmenopausal osteoporotic women.
Ahmad I, Jafar T, Mahdi F, Arshad MD, Das SK, Waliullah S, Rizvi I, Mahdi AA
Indian journal of experimental biology54(11)788-93(2016 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following BGLAP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BGLAP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26597	NM_199173.6 Latest version!	Homo sapiens bone gamma-carboxyglutamate protein (BGLAP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu26597	NM_199173.5	Homo sapiens bone gamma-carboxyglutamate protein (BGLAP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BGLAP ( NM_199173.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_954642.1 Homo sapiens bone gamma-carboxyglutamate protein (BGLAP), mRNA.

Price & Availability↑

CloneID	OHu26597
Clone ID Related Accession (Same CDS sequence)	NM_199173.5 , NM_199173.6
Accession Version	NM_199173.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 303bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1512403200000
Organism	Homo sapiens(human)
Product	osteocalcin preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL135927.14, BU622466.1, BC113432.1 and BQ774541.1. This sequence is a reference standard in the RefSeqGene project. On Jul 1, 2015 this sequence version replaced NM_199173.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU622466.1, CA428336.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGAGCCC TCACACTCCT CGCCCTATTG GCCCTGGCCG CACTTTGCAT CGCTGGCCAG 
GCAGGTGCGA AGCCCAGCGG TGCAGAGTCC AGCAAAGGTG CAGCCTTTGT GTCCAAGCAG 
GAGGGCAGCG AGGTAGTGAA GAGACCCAGG CGCTACCTGT ATCAATGGCT GGGAGCCCCA 
GTCCCCTACC CGGATCCCCT GGAGCCCAGG AGGGAGGTGT GTGAGCTCAA TCCGGACTGT 
GACGAGTTGG CTGACCACAT CGGCTTTCAG GAGGCCTATC GGCGCTTCTA CGGCCCGGTC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_954642.1
CDS	271..573
Translation	MRALTLLALLALAALCIAGQAGAKPSGAESSKGAAFVSKQEGSEVVKRPRRYLYQWLGAPVPYPDPLEPRREVCELNPDCDELADHIGFQEAYRRFYGPV

Target ORF information:

RefSeq Version	NM_199173.5
Organism	Homo sapiens(human)
Definition	Homo sapiens bone gamma-carboxyglutamate protein (BGLAP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_199173.5

ORF Insert Sequence:

ATGAGAGCCC TCACACTCCT CGCCCTATTG GCCCTGGCCG CACTTTGCAT CGCTGGCCAG 
GCAGGTGCGA AGCCCAGCGG TGCAGAGTCC AGCAAAGGTG CAGCCTTTGT GTCCAAGCAG 
GAGGGCAGCG AGGTAGTGAA GAGACCCAGG CGCTACCTGT ATCAATGGCT GGGAGCCCCA 
GTCCCCTACC CGGATCCCCT GGAGCCCAGG AGGGAGGTGT GTGAGCTCAA TCCGGACTGT 
GACGAGTTGG CTGACCACAT CGGCTTTCAG GAGGCCTATC GGCGCTTCTA CGGCCCGGTC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BGLAP ( NM_199173.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_954642.1 Homo sapiens bone gamma-carboxyglutamate protein (BGLAP), mRNA.

Price & Availability↑

CloneID	OHu26597
Clone ID Related Accession (Same CDS sequence)	NM_199173.5 , NM_199173.6
Accession Version	NM_199173.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 303bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575820800000
Organism	Homo sapiens(human)
Product	osteocalcin preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC113432.1 and BQ774541.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_199173.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU622466.1, CA428336.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000368272.5/ ENSP00000357255.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGAGCCC TCACACTCCT CGCCCTATTG GCCCTGGCCG CACTTTGCAT CGCTGGCCAG 
GCAGGTGCGA AGCCCAGCGG TGCAGAGTCC AGCAAAGGTG CAGCCTTTGT GTCCAAGCAG 
GAGGGCAGCG AGGTAGTGAA GAGACCCAGG CGCTACCTGT ATCAATGGCT GGGAGCCCCA 
GTCCCCTACC CGGATCCCCT GGAGCCCAGG AGGGAGGTGT GTGAGCTCAA TCCGGACTGT 
GACGAGTTGG CTGACCACAT CGGCTTTCAG GAGGCCTATC GGCGCTTCTA CGGCCCGGTC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_954642.1
CDS	49..351
Translation	MRALTLLALLALAALCIAGQAGAKPSGAESSKGAAFVSKQEGSEVVKRPRRYLYQWLGAPVPYPDPLEPRREVCELNPDCDELADHIGFQEAYRRFYGPV

Target ORF information:

RefSeq Version	NM_199173.6
Organism	Homo sapiens(human)
Definition	Homo sapiens bone gamma-carboxyglutamate protein (BGLAP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_199173.6

ORF Insert Sequence:

ATGAGAGCCC TCACACTCCT CGCCCTATTG GCCCTGGCCG CACTTTGCAT CGCTGGCCAG 
GCAGGTGCGA AGCCCAGCGG TGCAGAGTCC AGCAAAGGTG CAGCCTTTGT GTCCAAGCAG 
GAGGGCAGCG AGGTAGTGAA GAGACCCAGG CGCTACCTGT ATCAATGGCT GGGAGCCCCA 
GTCCCCTACC CGGATCCCCT GGAGCCCAGG AGGGAGGTGT GTGAGCTCAA TCCGGACTGT 
GACGAGTTGG CTGACCACAT CGGCTTTCAG GAGGCCTATC GGCGCTTCTA CGGCCCGGTC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Circulating Levels of Osteoprotegerin, Osteocalcin and Osteopontin in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.
Immunological investigations48(2)107-120(2019 Feb)
Liu LN,Mao YM,Zhao CN,Wang H,Yuan FF,Li XM,Pan HF

The Association Between Osteocalcin and Chronic Inflammation in Patients with Type 2 Diabetes Mellitus.
Calcified tissue international103(6)599-605(2018 12)
Kanazawa I,Tanaka S,Sugimoto T

Correlations between serum concentration of three bone-derived factors and obesity and visceral fat accumulation in a cohort of middle aged men and women.
Cardiovascular diabetology17(1)143(2018 11)
Xu Y,Ma X,Pan X,He X,Xiao Y,Bao Y

Serum Osteocalcin Levels in Girls with Central Precocious Puberty: Relation to the Onset of Puberty.
The Tohoku journal of experimental medicine245(4)239-243(2018 08)
Lee WY,Jung G,Kim HR,Nam HK,Rhie YJ,Lee KH

Osteocalcin HindIII gene polymorphism not associated with bone mineral density—A study in North Indian postmenopausal osteoporotic women.
Indian journal of experimental biology54(11)788-93(2016 Nov)
Ahmad I,Jafar T,Mahdi F,Arshad MD,Das SK,Waliullah S,Rizvi I,Mahdi AA