RRM2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RRM2
Entrez Gene ID	6241
Full Name	ribonucleotide reductase regulatory subunit M2
Synonyms	R2,RR2,RR2M
General protein information	Preferred Names ribonucleotide reductase regulatory subunit M2 Names ribonucleoside-diphosphate reductase subunit M2 ribonucleotide reductase M2 polypeptide ribonucleotide reductase small chain ribonucleotide reductase small subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p25.1
Summary	This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009].
Disorder MIM:	180390

mRNA and Protein(s)

mRNA	Protein	Name
NM_001034.4	NP_001025.1	ribonucleoside-diphosphate reductase subunit M2 isoform 2
NM_001165931.1	NP_001159403.1	ribonucleoside-diphosphate reductase subunit M2 isoform 1
NM_001034.3	NP_001025.1	ribonucleoside-diphosphate reductase subunit M2 isoform 2

Pathways from BioSystems

Homologies

Eremothecium gossypii	AGOS_AAL136C	NP_982406.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006818	XP_308927.4
Macaca mulatta (Rhesus monkey)	RRM2	XP_001091447.2
Canis lupus familiaris (dog)	RRM2	XP_540076.2
Gallus gallus (chicken)	RRM2	XP_004935811.1
Schizosaccharomyces pombe (fission yeast)	suc22	NP_596546.1
Danio rerio (zebrafish)	rrm2	NP_571525.1
Drosophila melanogaster (fruit fly)	RnrS	NP_525111.1
Xenopus tropicalis (tropical clawed frog)	rrm2.2	NP_001007890.1
Danio rerio (zebrafish)	LOC100330864	XP_002665783.1
Kluyveromyces lactis	KLLA0F15103g	XP_455757.1
Neurospora crassa	NCU07887	XP_962820.1
Homo sapiens (human)	RRM2	NP_001159403.1
Pan troglodytes (chimpanzee)	RRM2	XP_003949799.1
Arabidopsis thaliana (thale cress)	TSO2	NP_189342.1
Oryza sativa (rice)	Os06g0127900	NP_001056668.1
Magnaporthe oryzae (rice blast fungus)	MGG_06408	XP_003717161.1
Bos taurus (cattle)	RRM2	NP_001231110.1
Mus musculus (house mouse)	Rrm2	NP_033130.1
Rattus norvegicus (Norway rat)	Rrm2	NP_001020911.1
Caenorhabditis elegans (roundworm)	rnr-2	NP_497821.1
Saccharomyces cerevisiae (baker's yeast)	RNR2	NP_012508.1
Rattus norvegicus (Norway rat)	LOC100359539	XP_006255398.1

Gene Ontology
Bibliography

Related articles in PubMed

Potential tumor‑suppressive role of microRNA‑99a‑3p in sunitinib‑resistant renal cell carcinoma cells through the regulation of RRM2.
Osako Y, Yoshino H, Sakaguchi T, Sugita S, Yonemori M, Nakagawa M, Enokida H
International journal of oncology54(5)1759-1770(2019 May)

DSCAM-AS1 promotes tumor growth of breast cancer by reducing miR-204-5p and up-regulating RRM2.
Liang WH, Li N, Yuan ZQ, Qian XL, Wang ZH
Molecular carcinogenesis58(4)461-473(2019 04)

Ribonucleotide reductase M2 promotes RNA replication of hepatitis C virus by protecting NS5B protein from hPLIC1-dependent proteasomal degradation.
Kitab B, Satoh M, Ohmori Y, Munakata T, Sudoh M, Kohara M, Tsukiyama-Kohara K
The Journal of biological chemistry294(15)5759-5773(2019 04)

Tumor suppressive activity of PIWI-interacting RNA in human fibrosarcoma mediated through repression of RRM2.
Das B, Roy J, Jain N, Mallick B
Molecular carcinogenesis58(3)344-357(2019 03)

Clinical pharmacology and clinical trials of ribonucleotide reductase inhibitors: is it a viable cancer therapy?
Mannargudi MB, Deb S
Journal of cancer research and clinical oncology143(8)1499-1529(2017 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following RRM2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RRM2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21041	NM_001034.4 Latest version!	Homo sapiens ribonucleotide reductase regulatory subunit M2 (RRM2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
OHu21349	NM_001165931.1 Latest version!	Homo sapiens ribonucleotide reductase regulatory subunit M2 (RRM2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
View Old Accession Versions >>
OHu21041	NM_001034.3	Homo sapiens ribonucleotide reductase regulatory subunit M2 (RRM2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RRM2 ( NM_001034.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001025.1 Homo sapiens ribonucleotide reductase regulatory subunit M2 (RRM2), transcript variant 2, mRNA.

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CloneID	OHu21041
Clone ID Related Accession (Same CDS sequence)	NM_001034.4 , NM_001034.3
Accession Version	NM_001034.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1170bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	ribonucleoside-diphosphate reductase subunit M2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC104794.4, X59618.1, AC118058.3 and BM994533.1. On Nov 22, 2018 this sequence version replaced NM_001034.3. Transcript Variant: This variant (2) uses an alternative downstream promoter, and it thus has a shorter 5' UTR and uses a downstream translational start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. CCDS Note: This CCDS represents the transcript derived from the downstream promoter of this gene. Studies in both PMIDs 10631117 and 11978970 support the presence of the downstream promoter, as do the 5' extents of several human and homologous transcripts. PMID:11978970 also provides evidence for an upstream promoter; the transcript derived from the upstream promoter would encode a protein that is 60 aa longer at the N-terminus. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK313719.1, X59618.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000304567.10/ ENSP00000302955.4 RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTCTCCC TCCGTGTCCC GCTCGCGCCC ATCACGGACC CGCAGCAGCT GCAGCTCTCG 
CCGCTGAAGG GGCTCAGCTT GGTCGACAAG GAGAACACGC CGCCGGCCCT GAGCGGGACC 
CGCGTCCTGG CCAGCAAGAC CGCGAGGAGG ATCTTCCAGG AGCCCACGGA GCCGAAAACT 
AAAGCAGCTG CCCCCGGCGT GGAGGATGAG CCGCTGCTGA GAGAAAACCC CCGCCGCTTT 
GTCATCTTCC CCATCGAGTA CCATGATATC TGGCAGATGT ATAAGAAGGC AGAGGCTTCC 
TTTTGGACCG CCGAGGAGGT GGACCTCTCC AAGGACATTC AGCACTGGGA ATCCCTGAAA 
CCCGAGGAGA GATATTTTAT ATCCCATGTT CTGGCTTTCT TTGCAGCAAG CGATGGCATA 
GTAAATGAAA ACTTGGTGGA GCGATTTAGC CAAGAAGTTC AGATTACAGA AGCCCGCTGT 
TTCTATGGCT TCCAAATTGC CATGGAAAAC ATACATTCTG AAATGTATAG TCTTCTTATT 
GACACTTACA TAAAAGATCC CAAAGAAAGG GAATTTCTCT TCAATGCCAT TGAAACGATG 
CCTTGTGTCA AGAAGAAGGC AGACTGGGCC TTGCGCTGGA TTGGGGACAA AGAGGCTACC 
TATGGTGAAC GTGTTGTAGC CTTTGCTGCA GTGGAAGGCA TTTTCTTTTC CGGTTCTTTT 
GCGTCGATAT TCTGGCTCAA GAAACGAGGA CTGATGCCTG GCCTCACATT TTCTAATGAA 
CTTATTAGCA GAGATGAGGG TTTACACTGT GATTTTGCTT GCCTGATGTT CAAACACCTG 
GTACACAAAC CATCGGAGGA GAGAGTAAGA GAAATAATTA TCAATGCTGT TCGGATAGAA 
CAGGAGTTCC TCACTGAGGC CTTGCCTGTG AAGCTCATTG GGATGAATTG CACTCTAATG 
AAGCAATACA TTGAGTTTGT GGCAGACAGA CTTATGCTGG AACTGGGTTT TAGCAAGGTT 
TTCAGAGTAG AGAACCCATT TGACTTTATG GAGAATATTT CACTGGAAGG AAAGACTAAC 
TTCTTTGAGA AGAGAGTAGG CGAGTATCAG AGGATGGGAG TGATGTCAAG TCCAACAGAG 
AATTCTTTTA CCTTGGATGC TGACTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001025.1
CDS	61..1230
Translation	MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKTKAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSSPTENSFTLDADF

Target ORF information:

RefSeq Version	NM_001034.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ribonucleotide reductase regulatory subunit M2 (RRM2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001034.4

ORF Insert Sequence:

ATGCTCTCCC TCCGTGTCCC GCTCGCGCCC ATCACGGACC CGCAGCAGCT GCAGCTCTCG 
CCGCTGAAGG GGCTCAGCTT GGTCGACAAG GAGAACACGC CGCCGGCCCT GAGCGGGACC 
CGCGTCCTGG CCAGCAAGAC CGCGAGGAGG ATCTTCCAGG AGCCCACGGA GCCGAAAACT 
AAAGCAGCTG CCCCCGGCGT GGAGGATGAG CCGCTGCTGA GAGAAAACCC CCGCCGCTTT 
GTCATCTTCC CCATCGAGTA CCATGATATC TGGCAGATGT ATAAGAAGGC AGAGGCTTCC 
TTTTGGACCG CCGAGGAGGT GGACCTCTCC AAGGACATTC AGCACTGGGA ATCCCTGAAA 
CCCGAGGAGA GATATTTTAT ATCCCATGTT CTGGCTTTCT TTGCAGCAAG CGATGGCATA 
GTAAATGAAA ACTTGGTGGA GCGATTTAGC CAAGAAGTTC AGATTACAGA AGCCCGCTGT 
TTCTATGGCT TCCAAATTGC CATGGAAAAC ATACATTCTG AAATGTATAG TCTTCTTATT 
GACACTTACA TAAAAGATCC CAAAGAAAGG GAATTTCTCT TCAATGCCAT TGAAACGATG 
CCTTGTGTCA AGAAGAAGGC AGACTGGGCC TTGCGCTGGA TTGGGGACAA AGAGGCTACC 
TATGGTGAAC GTGTTGTAGC CTTTGCTGCA GTGGAAGGCA TTTTCTTTTC CGGTTCTTTT 
GCGTCGATAT TCTGGCTCAA GAAACGAGGA CTGATGCCTG GCCTCACATT TTCTAATGAA 
CTTATTAGCA GAGATGAGGG TTTACACTGT GATTTTGCTT GCCTGATGTT CAAACACCTG 
GTACACAAAC CATCGGAGGA GAGAGTAAGA GAAATAATTA TCAATGCTGT TCGGATAGAA 
CAGGAGTTCC TCACTGAGGC CTTGCCTGTG AAGCTCATTG GGATGAATTG CACTCTAATG 
AAGCAATACA TTGAGTTTGT GGCAGACAGA CTTATGCTGG AACTGGGTTT TAGCAAGGTT 
TTCAGAGTAG AGAACCCATT TGACTTTATG GAGAATATTT CACTGGAAGG AAAGACTAAC 
TTCTTTGAGA AGAGAGTAGG CGAGTATCAG AGGATGGGAG TGATGTCAAG TCCAACAGAG 
AATTCTTTTA CCTTGGATGC TGACTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RRM2 ( NM_001034.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001025.1 Homo sapiens ribonucleotide reductase regulatory subunit M2 (RRM2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu21041
Clone ID Related Accession (Same CDS sequence)	NM_001034.4 , NM_001034.3
Accession Version	NM_001034.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1170bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1514217600000
Organism	Homo sapiens(human)
Product	ribonucleoside-diphosphate reductase subunit M2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC104794.4, X59618.1, AC118058.3 and BM994533.1. On Sep 29, 2009 this sequence version replaced NM_001034.2. Transcript Variant: This variant (2) uses an alternative downstream promoter, and it thus has a shorter 5' UTR and uses a downstream translational start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. CCDS Note: This CCDS represents the transcript derived from the downstream promoter of this gene. Studies in both PMIDs 10631117 and 11978970 support the presence of the downstream promoter, as do the 5' extents of several human and homologous transcripts. PMID:11978970 also provides evidence for an upstream promoter; the transcript derived from the upstream promoter would encode a protein that is 60 aa longer at the N-terminus. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.271088.1, X59618.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGCTCTCCC TCCGTGTCCC GCTCGCGCCC ATCACGGACC CGCAGCAGCT GCAGCTCTCG 
CCGCTGAAGG GGCTCAGCTT GGTCGACAAG GAGAACACGC CGCCGGCCCT GAGCGGGACC 
CGCGTCCTGG CCAGCAAGAC CGCGAGGAGG ATCTTCCAGG AGCCCACGGA GCCGAAAACT 
AAAGCAGCTG CCCCCGGCGT GGAGGATGAG CCGCTGCTGA GAGAAAACCC CCGCCGCTTT 
GTCATCTTCC CCATCGAGTA CCATGATATC TGGCAGATGT ATAAGAAGGC AGAGGCTTCC 
TTTTGGACCG CCGAGGAGGT GGACCTCTCC AAGGACATTC AGCACTGGGA ATCCCTGAAA 
CCCGAGGAGA GATATTTTAT ATCCCATGTT CTGGCTTTCT TTGCAGCAAG CGATGGCATA 
GTAAATGAAA ACTTGGTGGA GCGATTTAGC CAAGAAGTTC AGATTACAGA AGCCCGCTGT 
TTCTATGGCT TCCAAATTGC CATGGAAAAC ATACATTCTG AAATGTATAG TCTTCTTATT 
GACACTTACA TAAAAGATCC CAAAGAAAGG GAATTTCTCT TCAATGCCAT TGAAACGATG 
CCTTGTGTCA AGAAGAAGGC AGACTGGGCC TTGCGCTGGA TTGGGGACAA AGAGGCTACC 
TATGGTGAAC GTGTTGTAGC CTTTGCTGCA GTGGAAGGCA TTTTCTTTTC CGGTTCTTTT 
GCGTCGATAT TCTGGCTCAA GAAACGAGGA CTGATGCCTG GCCTCACATT TTCTAATGAA 
CTTATTAGCA GAGATGAGGG TTTACACTGT GATTTTGCTT GCCTGATGTT CAAACACCTG 
GTACACAAAC CATCGGAGGA GAGAGTAAGA GAAATAATTA TCAATGCTGT TCGGATAGAA 
CAGGAGTTCC TCACTGAGGC CTTGCCTGTG AAGCTCATTG GGATGAATTG CACTCTAATG 
AAGCAATACA TTGAGTTTGT GGCAGACAGA CTTATGCTGG AACTGGGTTT TAGCAAGGTT 
TTCAGAGTAG AGAACCCATT TGACTTTATG GAGAATATTT CACTGGAAGG AAAGACTAAC 
TTCTTTGAGA AGAGAGTAGG CGAGTATCAG AGGATGGGAG TGATGTCAAG TCCAACAGAG 
AATTCTTTTA CCTTGGATGC TGACTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001025.1
CDS	64..1233
Translation	MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKTKAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSSPTENSFTLDADF

Target ORF information:

RefSeq Version	NM_001034.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ribonucleotide reductase regulatory subunit M2 (RRM2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001034.3

ORF Insert Sequence:

ATGCTCTCCC TCCGTGTCCC GCTCGCGCCC ATCACGGACC CGCAGCAGCT GCAGCTCTCG 
CCGCTGAAGG GGCTCAGCTT GGTCGACAAG GAGAACACGC CGCCGGCCCT GAGCGGGACC 
CGCGTCCTGG CCAGCAAGAC CGCGAGGAGG ATCTTCCAGG AGCCCACGGA GCCGAAAACT 
AAAGCAGCTG CCCCCGGCGT GGAGGATGAG CCGCTGCTGA GAGAAAACCC CCGCCGCTTT 
GTCATCTTCC CCATCGAGTA CCATGATATC TGGCAGATGT ATAAGAAGGC AGAGGCTTCC 
TTTTGGACCG CCGAGGAGGT GGACCTCTCC AAGGACATTC AGCACTGGGA ATCCCTGAAA 
CCCGAGGAGA GATATTTTAT ATCCCATGTT CTGGCTTTCT TTGCAGCAAG CGATGGCATA 
GTAAATGAAA ACTTGGTGGA GCGATTTAGC CAAGAAGTTC AGATTACAGA AGCCCGCTGT 
TTCTATGGCT TCCAAATTGC CATGGAAAAC ATACATTCTG AAATGTATAG TCTTCTTATT 
GACACTTACA TAAAAGATCC CAAAGAAAGG GAATTTCTCT TCAATGCCAT TGAAACGATG 
CCTTGTGTCA AGAAGAAGGC AGACTGGGCC TTGCGCTGGA TTGGGGACAA AGAGGCTACC 
TATGGTGAAC GTGTTGTAGC CTTTGCTGCA GTGGAAGGCA TTTTCTTTTC CGGTTCTTTT 
GCGTCGATAT TCTGGCTCAA GAAACGAGGA CTGATGCCTG GCCTCACATT TTCTAATGAA 
CTTATTAGCA GAGATGAGGG TTTACACTGT GATTTTGCTT GCCTGATGTT CAAACACCTG 
GTACACAAAC CATCGGAGGA GAGAGTAAGA GAAATAATTA TCAATGCTGT TCGGATAGAA 
CAGGAGTTCC TCACTGAGGC CTTGCCTGTG AAGCTCATTG GGATGAATTG CACTCTAATG 
AAGCAATACA TTGAGTTTGT GGCAGACAGA CTTATGCTGG AACTGGGTTT TAGCAAGGTT 
TTCAGAGTAG AGAACCCATT TGACTTTATG GAGAATATTT CACTGGAAGG AAAGACTAAC 
TTCTTTGAGA AGAGAGTAGG CGAGTATCAG AGGATGGGAG TGATGTCAAG TCCAACAGAG 
AATTCTTTTA CCTTGGATGC TGACTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RRM2 ( NM_001165931.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001159403.1 Homo sapiens ribonucleotide reductase regulatory subunit M2 (RRM2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21349
Clone ID Related Accession (Same CDS sequence)	NM_001165931.1
Accession Version	NM_001165931.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1350bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1573488000000
Organism	Homo sapiens(human)
Product	ribonucleoside-diphosphate reductase subunit M2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA477511.1, X59618.1, AC104794.4, AC118058.3 and BM994533.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X59618.1, SRR1163657.554099.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGGAAGGG TCGGAGGCAT GGCACAGCCA ATGGGAAGGG CCGGGGCACC AAAGCCAATG 
GGAAGGGCCG GGAGCGCGCG GCGCGGGAGA TTTAAAGGCT GCTGGAGTGA GGGGTCGCCC 
GTGCACCCTG TCCCAGCCGT CCTGTCCTGG CTGCTCGCTC TGCTTCGCTG CGCCTCCACT 
ATGCTCTCCC TCCGTGTCCC GCTCGCGCCC ATCACGGACC CGCAGCAGCT GCAGCTCTCG 
CCGCTGAAGG GGCTCAGCTT GGTCGACAAG GAGAACACGC CGCCGGCCCT GAGCGGGACC 
CGCGTCCTGG CCAGCAAGAC CGCGAGGAGG ATCTTCCAGG AGCCCACGGA GCCGAAAACT 
AAAGCAGCTG CCCCCGGCGT GGAGGATGAG CCGCTGCTGA GAGAAAACCC CCGCCGCTTT 
GTCATCTTCC CCATCGAGTA CCATGATATC TGGCAGATGT ATAAGAAGGC AGAGGCTTCC 
TTTTGGACCG CCGAGGAGGT GGACCTCTCC AAGGACATTC AGCACTGGGA ATCCCTGAAA 
CCCGAGGAGA GATATTTTAT ATCCCATGTT CTGGCTTTCT TTGCAGCAAG CGATGGCATA 
GTAAATGAAA ACTTGGTGGA GCGATTTAGC CAAGAAGTTC AGATTACAGA AGCCCGCTGT 
TTCTATGGCT TCCAAATTGC CATGGAAAAC ATACATTCTG AAATGTATAG TCTTCTTATT 
GACACTTACA TAAAAGATCC CAAAGAAAGG GAATTTCTCT TCAATGCCAT TGAAACGATG 
CCTTGTGTCA AGAAGAAGGC AGACTGGGCC TTGCGCTGGA TTGGGGACAA AGAGGCTACC 
TATGGTGAAC GTGTTGTAGC CTTTGCTGCA GTGGAAGGCA TTTTCTTTTC CGGTTCTTTT 
GCGTCGATAT TCTGGCTCAA GAAACGAGGA CTGATGCCTG GCCTCACATT TTCTAATGAA 
CTTATTAGCA GAGATGAGGG TTTACACTGT GATTTTGCTT GCCTGATGTT CAAACACCTG 
GTACACAAAC CATCGGAGGA GAGAGTAAGA GAAATAATTA TCAATGCTGT TCGGATAGAA 
CAGGAGTTCC TCACTGAGGC CTTGCCTGTG AAGCTCATTG GGATGAATTG CACTCTAATG 
AAGCAATACA TTGAGTTTGT GGCAGACAGA CTTATGCTGG AACTGGGTTT TAGCAAGGTT 
TTCAGAGTAG AGAACCCATT TGACTTTATG GAGAATATTT CACTGGAAGG AAAGACTAAC 
TTCTTTGAGA AGAGAGTAGG CGAGTATCAG AGGATGGGAG TGATGTCAAG TCCAACAGAG 
AATTCTTTTA CCTTGGATGC TGACTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001159403.1
CDS	52..1401
Translation	MGRVGGMAQPMGRAGAPKPMGRAGSARRGRFKGCWSEGSPVHPVPAVLSWLLALLRCASTMLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKTKAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSSPTENSFTLDADF

Target ORF information:

RefSeq Version	NM_001165931.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ribonucleotide reductase regulatory subunit M2 (RRM2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001165931.1

ORF Insert Sequence:

ATGGGAAGGG TCGGAGGCAT GGCACAGCCA ATGGGAAGGG CCGGGGCACC AAAGCCAATG 
GGAAGGGCCG GGAGCGCGCG GCGCGGGAGA TTTAAAGGCT GCTGGAGTGA GGGGTCGCCC 
GTGCACCCTG TCCCAGCCGT CCTGTCCTGG CTGCTCGCTC TGCTTCGCTG CGCCTCCACT 
ATGCTCTCCC TCCGTGTCCC GCTCGCGCCC ATCACGGACC CGCAGCAGCT GCAGCTCTCG 
CCGCTGAAGG GGCTCAGCTT GGTCGACAAG GAGAACACGC CGCCGGCCCT GAGCGGGACC 
CGCGTCCTGG CCAGCAAGAC CGCGAGGAGG ATCTTCCAGG AGCCCACGGA GCCGAAAACT 
AAAGCAGCTG CCCCCGGCGT GGAGGATGAG CCGCTGCTGA GAGAAAACCC CCGCCGCTTT 
GTCATCTTCC CCATCGAGTA CCATGATATC TGGCAGATGT ATAAGAAGGC AGAGGCTTCC 
TTTTGGACCG CCGAGGAGGT GGACCTCTCC AAGGACATTC AGCACTGGGA ATCCCTGAAA 
CCCGAGGAGA GATATTTTAT ATCCCATGTT CTGGCTTTCT TTGCAGCAAG CGATGGCATA 
GTAAATGAAA ACTTGGTGGA GCGATTTAGC CAAGAAGTTC AGATTACAGA AGCCCGCTGT 
TTCTATGGCT TCCAAATTGC CATGGAAAAC ATACATTCTG AAATGTATAG TCTTCTTATT 
GACACTTACA TAAAAGATCC CAAAGAAAGG GAATTTCTCT TCAATGCCAT TGAAACGATG 
CCTTGTGTCA AGAAGAAGGC AGACTGGGCC TTGCGCTGGA TTGGGGACAA AGAGGCTACC 
TATGGTGAAC GTGTTGTAGC CTTTGCTGCA GTGGAAGGCA TTTTCTTTTC CGGTTCTTTT 
GCGTCGATAT TCTGGCTCAA GAAACGAGGA CTGATGCCTG GCCTCACATT TTCTAATGAA 
CTTATTAGCA GAGATGAGGG TTTACACTGT GATTTTGCTT GCCTGATGTT CAAACACCTG 
GTACACAAAC CATCGGAGGA GAGAGTAAGA GAAATAATTA TCAATGCTGT TCGGATAGAA 
CAGGAGTTCC TCACTGAGGC CTTGCCTGTG AAGCTCATTG GGATGAATTG CACTCTAATG 
AAGCAATACA TTGAGTTTGT GGCAGACAGA CTTATGCTGG AACTGGGTTT TAGCAAGGTT 
TTCAGAGTAG AGAACCCATT TGACTTTATG GAGAATATTT CACTGGAAGG AAAGACTAAC 
TTCTTTGAGA AGAGAGTAGG CGAGTATCAG AGGATGGGAG TGATGTCAAG TCCAACAGAG 
AATTCTTTTA CCTTGGATGC TGACTTCTAA