| Gene Symbol | SPCS3 |
| Entrez Gene ID | 60559 |
| Full Name | signal peptidase complex subunit 3 |
| Synonyms | PRO3567,SPC22/23,SPC3,YLR066W |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome |
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SPCS3 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following SPCS3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SPCS3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu32099 Clone ID Related Accession (Same CDS sequence) NM_021928.3 , NM_021928.4 Accession Version NM_021928.3 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 543bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1506787200000 Organism Homo sapiens(human) Product signal peptidase complex subunit 3 Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB285025.1, AK026302.1 and AC019163.8. On Jan 22, 2009 this sequence version replaced NM_021928.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.223579.1, SRR1660807.2266.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541ATGAACACGG TGCTGTCGCG GGCGAACTCA CTGTTCGCCT TCTCGCTGAG CGTGATGGCG
GCGCTCACCT TCGGCTGCTT CATCACCACC GCCTTCAAAG ACAGGAGCGT CCCGGTGCGG
CTGCACGTCT CGCGGATCAT GCTAAAAAAT GTAGAAGATT TCACTGGACC TAGAGAAAGA
AGTGATCTGG GATTTATCAC ATTTGATATA ACTGCTGATC TAGAGAATAT ATTTGATTGG
AATGTTAAGC AGTTGTTTCT TTATTTATCA GCAGAATATT CAACAAAAAA TAATGCTCTG
AACCAAGTTG TCCTATGGGA CAAGATTGTT TTGAGAGGTG ATAATCCGAA GCTGCTGCTG
AAAGATATGA AAACAAAATA TTTTTTCTTT GACGATGGAA ATGGTCTCAA GGGAAACAGG
AATGTCACTT TGACCCTGTC TTGGAACGTC GTACCAAATG CTGGAATTCT ACCTCTTGTG
ACAGGATCAG GACACGTATC TGTCCCATTT CCAGATACAT ATGAAATAAC GAAGAGTTAT
TAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_068747.1 CDS 139..681 Translation 
Target ORF information:
RefSeq Version NM_021928.3 Organism Homo sapiens(human) Definition Homo sapiens signal peptidase complex subunit 3 (SPCS3), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_021928.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541ATGAACACGG TGCTGTCGCG GGCGAACTCA CTGTTCGCCT TCTCGCTGAG CGTGATGGCG
GCGCTCACCT TCGGCTGCTT CATCACCACC GCCTTCAAAG ACAGGAGCGT CCCGGTGCGG
CTGCACGTCT CGCGGATCAT GCTAAAAAAT GTAGAAGATT TCACTGGACC TAGAGAAAGA
AGTGATCTGG GATTTATCAC ATTTGATATA ACTGCTGATC TAGAGAATAT ATTTGATTGG
AATGTTAAGC AGTTGTTTCT TTATTTATCA GCAGAATATT CAACAAAAAA TAATGCTCTG
AACCAAGTTG TCCTATGGGA CAAGATTGTT TTGAGAGGTG ATAATCCGAA GCTGCTGCTG
AAAGATATGA AAACAAAATA TTTTTTCTTT GACGATGGAA ATGGTCTCAA GGGAAACAGG
AATGTCACTT TGACCCTGTC TTGGAACGTC GTACCAAATG CTGGAATTCT ACCTCTTGTG
ACAGGATCAG GACACGTATC TGTCCCATTT CCAGATACAT ATGAAATAAC GAAGAGTTAT
TAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu32099 Clone ID Related Accession (Same CDS sequence) NM_021928.3 , NM_021928.4 Accession Version NM_021928.4 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 543bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1570550400000 Organism Homo sapiens(human) Product signal peptidase complex subunit 3 Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK026302.1 and AC019163.8. On Nov 23, 2018 this sequence version replaced NM_021928.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.97109.1, SRR1660807.2266.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000503362.2/ ENSP00000427463.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541ATGAACACGG TGCTGTCGCG GGCGAACTCA CTGTTCGCCT TCTCGCTGAG CGTGATGGCG
GCGCTCACCT TCGGCTGCTT CATCACCACC GCCTTCAAAG ACAGGAGCGT CCCGGTGCGG
CTGCACGTCT CGCGGATCAT GCTAAAAAAT GTAGAAGATT TCACTGGACC TAGAGAAAGA
AGTGATCTGG GATTTATCAC ATTTGATATA ACTGCTGATC TAGAGAATAT ATTTGATTGG
AATGTTAAGC AGTTGTTTCT TTATTTATCA GCAGAATATT CAACAAAAAA TAATGCTCTG
AACCAAGTTG TCCTATGGGA CAAGATTGTT TTGAGAGGTG ATAATCCGAA GCTGCTGCTG
AAAGATATGA AAACAAAATA TTTTTTCTTT GACGATGGAA ATGGTCTCAA GGGAAACAGG
AATGTCACTT TGACCCTGTC TTGGAACGTC GTACCAAATG CTGGAATTCT ACCTCTTGTG
ACAGGATCAG GACACGTATC TGTCCCATTT CCAGATACAT ATGAAATAAC GAAGAGTTAT
TAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_068747.1 CDS 112..654 Translation
Target ORF information:
RefSeq Version NM_021928.4 Organism Homo sapiens(human) Definition Homo sapiens signal peptidase complex subunit 3 (SPCS3), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_021928.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541ATGAACACGG TGCTGTCGCG GGCGAACTCA CTGTTCGCCT TCTCGCTGAG CGTGATGGCG
GCGCTCACCT TCGGCTGCTT CATCACCACC GCCTTCAAAG ACAGGAGCGT CCCGGTGCGG
CTGCACGTCT CGCGGATCAT GCTAAAAAAT GTAGAAGATT TCACTGGACC TAGAGAAAGA
AGTGATCTGG GATTTATCAC ATTTGATATA ACTGCTGATC TAGAGAATAT ATTTGATTGG
AATGTTAAGC AGTTGTTTCT TTATTTATCA GCAGAATATT CAACAAAAAA TAATGCTCTG
AACCAAGTTG TCCTATGGGA CAAGATTGTT TTGAGAGGTG ATAATCCGAA GCTGCTGCTG
AAAGATATGA AAACAAAATA TTTTTTCTTT GACGATGGAA ATGGTCTCAA GGGAAACAGG
AATGTCACTT TGACCCTGTC TTGGAACGTC GTACCAAATG CTGGAATTCT ACCTCTTGTG
ACAGGATCAG GACACGTATC TGTCCCATTT CCAGATACAT ATGAAATAAC GAAGAGTTAT
TAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
-
PubMed
Inverting the Topology of a Transmembrane Protein by Regulating the Translocation of the First Transmembrane Helix.
Molecular cell63(4)567-578(2016 08)
Chen Q,Denard B,Lee CE,Han S,Ye JS,Ye J
A CRISPR screen defines a signal peptide processing pathway required by flaviviruses.
Nature535(7610)164-8(2016 07)
Zhang R,Miner JJ,Gorman MJ,Rausch K,Ramage H,White JP,Zuiani A,Zhang P,Fernandez E,Zhang Q,Dowd KA,Pierson TC,Cherry S,Diamond MS
Defective minor spliceosome mRNA processing results in isolated familial growth hormone deficiency.
EMBO molecular medicine6(3)299-306(2014 03)
Argente J,Flores R,Gutiérrez-Arumí A,Verma B,Martos-Moreno GÁ,Cuscó I,Oghabian A,Chowen JA,Frilander MJ,Pérez-Jurado LA
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Genome research13(10)2265-70(2003 Oct)
Clark HF,Gurney AL,Abaya E,Baker K,Baldwin D,Brush J,Chen J,Chow B,Chui C,Crowley C,Currell B,Deuel B,Dowd P,Eaton D,Foster J,Grimaldi C,Gu Q,Hass PE,Heldens S,Huang A,Kim HS,Klimowski L,Jin Y,Johnson S,Lee J,Lewis L,Liao D,Mark M,Robbie E,Sanchez C,Schoenfeld J,Seshagiri S,Simmons L,Singh J,Smith V,Stinson J,Vagts A,Vandlen R,Watanabe C,Wieand D,Woods K,Xie MH,Yansura D,Yi S,Yu G,Yuan J,Zhang M,Zhang Z,Goddard A,Wood WI,Godowski P,Gray A
Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.
EMBO reports1(3)287-92(2000 Sep)
Simpson JC,Wellenreuther R,Poustka A,Pepperkok R,Wiemann S
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