| Gene Symbol | BCL6 |
| Entrez Gene ID | 604 |
| Full Name | B cell CLL/lymphoma 6 |
| Synonyms | BCL5,BCL6A,LAZ3,ZBTB27,ZNF51 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]. |
| Disorder MIM: | |
| Disorder Html: | Lymphoma, B-cell (2) |

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