RAD21 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RAD21
Entrez Gene ID	5885
Full Name	RAD21 cohesin complex component
Synonyms	CDLS4,HR21,HRAD21,MCD1,NXP1,SCC1,hHR21
General protein information	Preferred Names RAD21 cohesin complex component Names double-strand-break repair protein rad21 homolog NXP-1 RAD21 homolog SCC1 homolog kleisin nuclear matrix protein 1 protein involved in DNA double-strand break repair sister chromatid cohesion 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q24.11
Summary	The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. [provided by RefSeq, Jul 2008].
Disorder MIM:	606462
Disorder Html:	Cornelia de Lange syndrome 4, 614701 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_006265.3	NP_006256.1	double-strand-break repair protein rad21 homolog
NM_006265.2	NP_006256.1	double-strand-break repair protein rad21 homolog

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	vtd	NP_001015132.1
Homo sapiens (human)	RAD21	NP_006256.1
Macaca mulatta (Rhesus monkey)	RAD21	XP_001095142.1
Bos taurus (cattle)	RAD21	NP_001029889.1
Canis lupus familiaris (dog)	RAD21	XP_539142.2
Mus musculus (house mouse)	Rad21	NP_033035.3
Gallus gallus (chicken)	RAD21	NP_001026121.1
Danio rerio (zebrafish)	LOC100536176	XP_003200317.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004560	XP_313862.4
Rattus norvegicus (Norway rat)	Rad21	NP_001020872.1
Danio rerio (zebrafish)	rad21b	NP_001038585.1
Xenopus tropicalis (tropical clawed frog)	rad21	XP_002940047.1
Pan troglodytes (chimpanzee)	RAD21	XP_003951384.1
Danio rerio (zebrafish)	rad21a	NP_955889.1

Gene Ontology
Bibliography

Related articles in PubMed

Dysregulation of the cohesin subunit RAD21 by Hepatitis C virus mediates host-virus interactions.
Perez S, Gevor M, Davidovich A, Kaspi A, Yamin K, Domovich T, Meirson T, Matityahu A, Brody Y, Stemmer SM, El-Osta A, Haviv I, Onn I, Gal-Tanamy M
Nucleic acids research47(5)2455-2471(2019 03)

Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing.
Carvajal-Maldonado D, Byrum AK, Jackson J, Wessel S, Lemaçon D, Guitton-Sert L, Quinet A, Tirman S, Graziano S, Masson JY, Cortez D, Gonzalo S, Mosammaparast N, Vindigni A
Nucleic acids research47(3)1294-1310(2019 02)

Expression of RAD21 immunoreactivity in myenteric neurons of the human and mouse small intestine.
Bianco F, Eisenman ST, Colmenares Aguilar MG, Bonora E, Clavenzani P, Linden DR, De Giorgio R, Farrugia G, Gibbons SJ
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society30(9)e13429(2018 09)

Cohesin RAD21 Gene Promoter Methylation in Patients with Chronic Lymphocytic Leukemia.
Ioannidou A, Zachaki S, Karakosta M, Daraki A, Roussou P, Manola KN
Cytogenetic and genome research154(3)126-131(2018)

Prognostic Biomarker Identification Through Integrating the Gene Signatures of Hepatocellular Carcinoma Properties.
Cai J, Li B, Zhu Y, Fang X, Zhu M, Wang M, Liu S, Jiang X, Zheng J, Zhang X, Chen P
EBioMedicine1918-30(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following RAD21 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RAD21 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26280	NM_006265.3 Latest version!	Homo sapiens RAD21 cohesin complex component (RAD21), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
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OHu26280	NM_006265.2	Homo sapiens RAD21 cohesin complex component (RAD21), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RAD21 ( NM_006265.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006256.1 Homo sapiens RAD21 cohesin complex component (RAD21), mRNA.

Price & Availability↑

CloneID	OHu26280
Clone ID Related Accession (Same CDS sequence)	NM_006265.3 , NM_006265.2
Accession Version	NM_006265.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1896bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1578067200000
Organism	Homo sapiens(human)
Product	double-strand-break repair protein rad21 homolog
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA328186.1 and BC050381.1. On Aug 31, 2019 this sequence version replaced NM_006265.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC050381.1, D38551.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTCTACG CACATTTTGT TCTCAGTAAA AGAGGGCCTC TGGCCAAAAT TTGGCTAGCG 
GCCCATTGGG ATAAGAAGCT AACCAAAGCC CATGTGTTCG AGTGTAATTT AGAGAGCAGC 
GTGGAGAGTA TCATCTCACC AAAGGTGAAA ATGGCATTAC GGACATCAGG ACATCTCTTA 
CTGGGAGTAG TTCGAATCTA TCACAGGAAA GCCAAATACC TTCTTGCAGA CTGTAATGAA 
GCATTCATTA AGATAAAGAT GGCTTTTCGG CCAGGTGTGG TTGACCTGCC TGAGGAAAAT 
CGGGAAGCAG CTTATAATGC CATTACTTTA CCTGAAGAAT TTCATGACTT TGATCAGCCA 
CTGCCTGACT TAGATGACAT CGATGTGGCC CAGCAGTTCA GCTTGAATCA GAGTAGAGTG 
GAAGAGATAA CCATGAGAGA AGAAGTTGGG AACATCAGTA TTTTACAAGA AAATGATTTT 
GGTGATTTTG GAATGGATGA TCGTGAGATA ATGAGAGAAG GCAGTGCTTT TGAGGATGAC 
GACATGTTAG TAAGCACTAC TACTTCTAAC CTCCTATTAG AGTCTGAACA GAGCACCAGC 
AATCTGAATG AGAAAATTAA CCATTTAGAA TATGAAGATC AATATAAGGA TGATAATTTT 
GGAGAAGGAA ATGATGGTGG AATATTAGAT GACAAACTTA TTAGTAATAA TGATGGCGGT 
ATCTTTGATG ATCCCCCTGC CCTCTCTGAG GCAGGGGTGA TGTTGCCAGA GCAGCCTGCA 
CATGACGATA TGGATGAGGA TGATAATGTA TCAATGGGTG GGCCTGATAG TCCTGATTCA 
GTGGATCCCG TTGAACCAAT GCCAACCATG ACTGATCAAA CAACACTTGT TCCAAATGAG 
GAAGAAGCAT TTGCATTGGA GCCTATTGAT ATAACTGTTA AAGAAACAAA AGCCAAGAGG 
AAGAGGAAGC TAATTGTTGA CAGTGTCAAA GAGTTGGATA GCAAGACAAT TAGAGCCCAA 
CTTAGTGATT ATTCAGATAT TGTTACTACT TTGGATCTGG CACCGCCCAC CAAGAAATTG 
ATGATGTGGA AAGAGACAGG AGGAGTAGAA AAACTGTTTT CTTTACCTGC TCAGCCTTTG 
TGGAATAACA GACTACTGAA GCTCTTTACA CGCTGTCTTA CACCGCTTGT ACCAGAAGAC 
CTTAGAAAAA GGAGGAAAGG AGGAGAGGCA GATAATTTGG ATGAATTCCT CAAAGAATTT 
GAAAATCCAG AGGTTCCTAG AGAGGACCAG CAACAGCAGC ATCAGCAGCG TGATGTTATC 
GATGAGCCCA TTATTGAAGA GCCAAGCCGC CTCCAGGAGT CAGTGATGGA GGCCAGCAGA 
ACAAACATAG ATGAGTCAGC TATGCCTCCA CCACCACCTC AGGGAGTTAA GCGAAAAGCT 
GGACAAATTG ACCCAGAGCC TGTGATGCCT CCTCAGCAGG TAGAGCAGAT GGAAATACCA 
CCTGTAGAGC TTCCCCCAGA AGAACCTCCA AATATCTGTC AGCTAATACC AGAGTTAGAA 
CTTCTGCCAG AAAAAGAGAA GGAGAAAGAG AAGGAAAAAG AAGATGATGA AGAGGAAGAG 
GATGAAGATG CATCAGGGGG CGATCAAGAT CAGGAAGAAA GAAGATGGAA CAAAAGGACT 
CAGCAGATGC TTCATGGTCT TCAGCGTGCT CTTGCTAAAA CTGGAGCTGA ATCTATCAGT 
TTGCTTGAGT TATGTCGAAA TACGAACAGA AAACAAGCTG CCGCAAAGTT CTACAGCTTC 
TTGGTTCTTA AAAAGCAGCA AGCTATTGAG CTGACACAGG AAGAACCGTA CAGTGACATC 
ATCGCAACAC CTGGACCAAG GTTCCATATT ATATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006256.1
CDS	199..2094
Translation	MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVRIYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDDDMLVSTTTSNLLLESEQSTSNLNEKINHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDDPPALSEAGVMLPEQPAHDDMDEDDNVSMGGPDSPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKLMMWKETGGVEKLFSLPAQPLWNNRLLKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREDQQQQHQQRDVIDEPIIEEPSRLQESVMEASRTNIDESAMPPPPPQGVKRKAGQIDPEPVMPPQQVEQMEIPPVELPPEEPPNICQLIPELELLPEKEKEKEKEKEDDEEEEDEDASGGDQDQEERRWNKRTQQMLHGLQRALAKTGAESISLLELCRNTNRKQAAAKFYSFLVLKKQQAIELTQEEPYSDIIATPGPRFHII

Target ORF information:

RefSeq Version	NM_006265.3
Organism	Homo sapiens(human)
Definition	Homo sapiens RAD21 cohesin complex component (RAD21), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006265.3

ORF Insert Sequence:

ATGTTCTACG CACATTTTGT TCTCAGTAAA AGAGGGCCTC TGGCCAAAAT TTGGCTAGCG 
GCCCATTGGG ATAAGAAGCT AACCAAAGCC CATGTGTTCG AGTGTAATTT AGAGAGCAGC 
GTGGAGAGTA TCATCTCACC AAAGGTGAAA ATGGCATTAC GGACATCAGG ACATCTCTTA 
CTGGGAGTAG TTCGAATCTA TCACAGGAAA GCCAAATACC TTCTTGCAGA CTGTAATGAA 
GCATTCATTA AGATAAAGAT GGCTTTTCGG CCAGGTGTGG TTGACCTGCC TGAGGAAAAT 
CGGGAAGCAG CTTATAATGC CATTACTTTA CCTGAAGAAT TTCATGACTT TGATCAGCCA 
CTGCCTGACT TAGATGACAT CGATGTGGCC CAGCAGTTCA GCTTGAATCA GAGTAGAGTG 
GAAGAGATAA CCATGAGAGA AGAAGTTGGG AACATCAGTA TTTTACAAGA AAATGATTTT 
GGTGATTTTG GAATGGATGA TCGTGAGATA ATGAGAGAAG GCAGTGCTTT TGAGGATGAC 
GACATGTTAG TAAGCACTAC TACTTCTAAC CTCCTATTAG AGTCTGAACA GAGCACCAGC 
AATCTGAATG AGAAAATTAA CCATTTAGAA TATGAAGATC AATATAAGGA TGATAATTTT 
GGAGAAGGAA ATGATGGTGG AATATTAGAT GACAAACTTA TTAGTAATAA TGATGGCGGT 
ATCTTTGATG ATCCCCCTGC CCTCTCTGAG GCAGGGGTGA TGTTGCCAGA GCAGCCTGCA 
CATGACGATA TGGATGAGGA TGATAATGTA TCAATGGGTG GGCCTGATAG TCCTGATTCA 
GTGGATCCCG TTGAACCAAT GCCAACCATG ACTGATCAAA CAACACTTGT TCCAAATGAG 
GAAGAAGCAT TTGCATTGGA GCCTATTGAT ATAACTGTTA AAGAAACAAA AGCCAAGAGG 
AAGAGGAAGC TAATTGTTGA CAGTGTCAAA GAGTTGGATA GCAAGACAAT TAGAGCCCAA 
CTTAGTGATT ATTCAGATAT TGTTACTACT TTGGATCTGG CACCGCCCAC CAAGAAATTG 
ATGATGTGGA AAGAGACAGG AGGAGTAGAA AAACTGTTTT CTTTACCTGC TCAGCCTTTG 
TGGAATAACA GACTACTGAA GCTCTTTACA CGCTGTCTTA CACCGCTTGT ACCAGAAGAC 
CTTAGAAAAA GGAGGAAAGG AGGAGAGGCA GATAATTTGG ATGAATTCCT CAAAGAATTT 
GAAAATCCAG AGGTTCCTAG AGAGGACCAG CAACAGCAGC ATCAGCAGCG TGATGTTATC 
GATGAGCCCA TTATTGAAGA GCCAAGCCGC CTCCAGGAGT CAGTGATGGA GGCCAGCAGA 
ACAAACATAG ATGAGTCAGC TATGCCTCCA CCACCACCTC AGGGAGTTAA GCGAAAAGCT 
GGACAAATTG ACCCAGAGCC TGTGATGCCT CCTCAGCAGG TAGAGCAGAT GGAAATACCA 
CCTGTAGAGC TTCCCCCAGA AGAACCTCCA AATATCTGTC AGCTAATACC AGAGTTAGAA 
CTTCTGCCAG AAAAAGAGAA GGAGAAAGAG AAGGAAAAAG AAGATGATGA AGAGGAAGAG 
GATGAAGATG CATCAGGGGG CGATCAAGAT CAGGAAGAAA GAAGATGGAA CAAAAGGACT 
CAGCAGATGC TTCATGGTCT TCAGCGTGCT CTTGCTAAAA CTGGAGCTGA ATCTATCAGT 
TTGCTTGAGT TATGTCGAAA TACGAACAGA AAACAAGCTG CCGCAAAGTT CTACAGCTTC 
TTGGTTCTTA AAAAGCAGCA AGCTATTGAG CTGACACAGG AAGAACCGTA CAGTGACATC 
ATCGCAACAC CTGGACCAAG GTTCCATATT ATATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAD21 ( NM_006265.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006256.1 Homo sapiens RAD21 cohesin complex component (RAD21), mRNA.

Price & Availability↑

CloneID	OHu26280
Clone ID Related Accession (Same CDS sequence)	NM_006265.3 , NM_006265.2
Accession Version	NM_006265.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1896bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1562256000000
Organism	Homo sapiens(human)
Product	double-strand-break repair protein rad21 homolog
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA328186.1 and BC050381.1. This sequence is a reference standard in the RefSeqGene project. On Oct 7, 2008 this sequence version replaced NM_006265.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC050381.1, SRR7346977.1634994.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTCTACG CACATTTTGT TCTCAGTAAA AGAGGGCCTC TGGCCAAAAT TTGGCTAGCG 
GCCCATTGGG ATAAGAAGCT AACCAAAGCC CATGTGTTCG AGTGTAATTT AGAGAGCAGC 
GTGGAGAGTA TCATCTCACC AAAGGTGAAA ATGGCATTAC GGACATCAGG ACATCTCTTA 
CTGGGAGTAG TTCGAATCTA TCACAGGAAA GCCAAATACC TTCTTGCAGA CTGTAATGAA 
GCATTCATTA AGATAAAGAT GGCTTTTCGG CCAGGTGTGG TTGACCTGCC TGAGGAAAAT 
CGGGAAGCAG CTTATAATGC CATTACTTTA CCTGAAGAAT TTCATGACTT TGATCAGCCA 
CTGCCTGACT TAGATGACAT CGATGTGGCC CAGCAGTTCA GCTTGAATCA GAGTAGAGTG 
GAAGAGATAA CCATGAGAGA AGAAGTTGGG AACATCAGTA TTTTACAAGA AAATGATTTT 
GGTGATTTTG GAATGGATGA TCGTGAGATA ATGAGAGAAG GCAGTGCTTT TGAGGATGAC 
GACATGTTAG TAAGCACTAC TACTTCTAAC CTCCTATTAG AGTCTGAACA GAGCACCAGC 
AATCTGAATG AGAAAATTAA CCATTTAGAA TATGAAGATC AATATAAGGA TGATAATTTT 
GGAGAAGGAA ATGATGGTGG AATATTAGAT GACAAACTTA TTAGTAATAA TGATGGCGGT 
ATCTTTGATG ATCCCCCTGC CCTCTCTGAG GCAGGGGTGA TGTTGCCAGA GCAGCCTGCA 
CATGACGATA TGGATGAGGA TGATAATGTA TCAATGGGTG GGCCTGATAG TCCTGATTCA 
GTGGATCCCG TTGAACCAAT GCCAACCATG ACTGATCAAA CAACACTTGT TCCAAATGAG 
GAAGAAGCAT TTGCATTGGA GCCTATTGAT ATAACTGTTA AAGAAACAAA AGCCAAGAGG 
AAGAGGAAGC TAATTGTTGA CAGTGTCAAA GAGTTGGATA GCAAGACAAT TAGAGCCCAA 
CTTAGTGATT ATTCAGATAT TGTTACTACT TTGGATCTGG CACCGCCCAC CAAGAAATTG 
ATGATGTGGA AAGAGACAGG AGGAGTAGAA AAACTGTTTT CTTTACCTGC TCAGCCTTTG 
TGGAATAACA GACTACTGAA GCTCTTTACA CGCTGTCTTA CACCGCTTGT ACCAGAAGAC 
CTTAGAAAAA GGAGGAAAGG AGGAGAGGCA GATAATTTGG ATGAATTCCT CAAAGAATTT 
GAAAATCCAG AGGTTCCTAG AGAGGACCAG CAACAGCAGC ATCAGCAGCG TGATGTTATC 
GATGAGCCCA TTATTGAAGA GCCAAGCCGC CTCCAGGAGT CAGTGATGGA GGCCAGCAGA 
ACAAACATAG ATGAGTCAGC TATGCCTCCA CCACCACCTC AGGGAGTTAA GCGAAAAGCT 
GGACAAATTG ACCCAGAGCC TGTGATGCCT CCTCAGCAGG TAGAGCAGAT GGAAATACCA 
CCTGTAGAGC TTCCCCCAGA AGAACCTCCA AATATCTGTC AGCTAATACC AGAGTTAGAA 
CTTCTGCCAG AAAAAGAGAA GGAGAAAGAG AAGGAAAAAG AAGATGATGA AGAGGAAGAG 
GATGAAGATG CATCAGGGGG CGATCAAGAT CAGGAAGAAA GAAGATGGAA CAAAAGGACT 
CAGCAGATGC TTCATGGTCT TCAGCGTGCT CTTGCTAAAA CTGGAGCTGA ATCTATCAGT 
TTGCTTGAGT TATGTCGAAA TACGAACAGA AAACAAGCTG CCGCAAAGTT CTACAGCTTC 
TTGGTTCTTA AAAAGCAGCA AGCTATTGAG CTGACACAGG AAGAACCGTA CAGTGACATC 
ATCGCAACAC CTGGACCAAG GTTCCATATT ATATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006256.1
CDS	289..2184
Translation	MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVRIYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDDDMLVSTTTSNLLLESEQSTSNLNEKINHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDDPPALSEAGVMLPEQPAHDDMDEDDNVSMGGPDSPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKLMMWKETGGVEKLFSLPAQPLWNNRLLKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREDQQQQHQQRDVIDEPIIEEPSRLQESVMEASRTNIDESAMPPPPPQGVKRKAGQIDPEPVMPPQQVEQMEIPPVELPPEEPPNICQLIPELELLPEKEKEKEKEKEDDEEEEDEDASGGDQDQEERRWNKRTQQMLHGLQRALAKTGAESISLLELCRNTNRKQAAAKFYSFLVLKKQQAIELTQEEPYSDIIATPGPRFHII

Target ORF information:

RefSeq Version	NM_006265.2
Organism	Homo sapiens(human)
Definition	Homo sapiens RAD21 cohesin complex component (RAD21), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006265.2

ORF Insert Sequence:

ATGTTCTACG CACATTTTGT TCTCAGTAAA AGAGGGCCTC TGGCCAAAAT TTGGCTAGCG 
GCCCATTGGG ATAAGAAGCT AACCAAAGCC CATGTGTTCG AGTGTAATTT AGAGAGCAGC 
GTGGAGAGTA TCATCTCACC AAAGGTGAAA ATGGCATTAC GGACATCAGG ACATCTCTTA 
CTGGGAGTAG TTCGAATCTA TCACAGGAAA GCCAAATACC TTCTTGCAGA CTGTAATGAA 
GCATTCATTA AGATAAAGAT GGCTTTTCGG CCAGGTGTGG TTGACCTGCC TGAGGAAAAT 
CGGGAAGCAG CTTATAATGC CATTACTTTA CCTGAAGAAT TTCATGACTT TGATCAGCCA 
CTGCCTGACT TAGATGACAT CGATGTGGCC CAGCAGTTCA GCTTGAATCA GAGTAGAGTG 
GAAGAGATAA CCATGAGAGA AGAAGTTGGG AACATCAGTA TTTTACAAGA AAATGATTTT 
GGTGATTTTG GAATGGATGA TCGTGAGATA ATGAGAGAAG GCAGTGCTTT TGAGGATGAC 
GACATGTTAG TAAGCACTAC TACTTCTAAC CTCCTATTAG AGTCTGAACA GAGCACCAGC 
AATCTGAATG AGAAAATTAA CCATTTAGAA TATGAAGATC AATATAAGGA TGATAATTTT 
GGAGAAGGAA ATGATGGTGG AATATTAGAT GACAAACTTA TTAGTAATAA TGATGGCGGT 
ATCTTTGATG ATCCCCCTGC CCTCTCTGAG GCAGGGGTGA TGTTGCCAGA GCAGCCTGCA 
CATGACGATA TGGATGAGGA TGATAATGTA TCAATGGGTG GGCCTGATAG TCCTGATTCA 
GTGGATCCCG TTGAACCAAT GCCAACCATG ACTGATCAAA CAACACTTGT TCCAAATGAG 
GAAGAAGCAT TTGCATTGGA GCCTATTGAT ATAACTGTTA AAGAAACAAA AGCCAAGAGG 
AAGAGGAAGC TAATTGTTGA CAGTGTCAAA GAGTTGGATA GCAAGACAAT TAGAGCCCAA 
CTTAGTGATT ATTCAGATAT TGTTACTACT TTGGATCTGG CACCGCCCAC CAAGAAATTG 
ATGATGTGGA AAGAGACAGG AGGAGTAGAA AAACTGTTTT CTTTACCTGC TCAGCCTTTG 
TGGAATAACA GACTACTGAA GCTCTTTACA CGCTGTCTTA CACCGCTTGT ACCAGAAGAC 
CTTAGAAAAA GGAGGAAAGG AGGAGAGGCA GATAATTTGG ATGAATTCCT CAAAGAATTT 
GAAAATCCAG AGGTTCCTAG AGAGGACCAG CAACAGCAGC ATCAGCAGCG TGATGTTATC 
GATGAGCCCA TTATTGAAGA GCCAAGCCGC CTCCAGGAGT CAGTGATGGA GGCCAGCAGA 
ACAAACATAG ATGAGTCAGC TATGCCTCCA CCACCACCTC AGGGAGTTAA GCGAAAAGCT 
GGACAAATTG ACCCAGAGCC TGTGATGCCT CCTCAGCAGG TAGAGCAGAT GGAAATACCA 
CCTGTAGAGC TTCCCCCAGA AGAACCTCCA AATATCTGTC AGCTAATACC AGAGTTAGAA 
CTTCTGCCAG AAAAAGAGAA GGAGAAAGAG AAGGAAAAAG AAGATGATGA AGAGGAAGAG 
GATGAAGATG CATCAGGGGG CGATCAAGAT CAGGAAGAAA GAAGATGGAA CAAAAGGACT 
CAGCAGATGC TTCATGGTCT TCAGCGTGCT CTTGCTAAAA CTGGAGCTGA ATCTATCAGT 
TTGCTTGAGT TATGTCGAAA TACGAACAGA AAACAAGCTG CCGCAAAGTT CTACAGCTTC 
TTGGTTCTTA AAAAGCAGCA AGCTATTGAG CTGACACAGG AAGAACCGTA CAGTGACATC 
ATCGCAACAC CTGGACCAAG GTTCCATATT ATATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dysregulation of the cohesin subunit RAD21 by Hepatitis C virus mediates host-virus interactions.
Nucleic acids research47(5)2455-2471(2019 03)
Perez S,Gevor M,Davidovich A,Kaspi A,Yamin K,Domovich T,Meirson T,Matityahu A,Brody Y,Stemmer SM,El-Osta A,Haviv I,Onn I,Gal-Tanamy M

Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing.
Nucleic acids research47(3)1294-1310(2019 02)
Carvajal-Maldonado D,Byrum AK,Jackson J,Wessel S,Lemaçon D,Guitton-Sert L,Quinet A,Tirman S,Graziano S,Masson JY,Cortez D,Gonzalo S,Mosammaparast N,Vindigni A

Expression of RAD21 immunoreactivity in myenteric neurons of the human and mouse small intestine.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society30(9)e13429(2018 09)
Bianco F,Eisenman ST,Colmenares Aguilar MG,Bonora E,Clavenzani P,Linden DR,De Giorgio R,Farrugia G,Gibbons SJ

Cohesin RAD21 Gene Promoter Methylation in Patients with Chronic Lymphocytic Leukemia.
Cytogenetic and genome research154(3)126-131(2018)
Ioannidou A,Zachaki S,Karakosta M,Daraki A,Roussou P,Manola KN

Prognostic Biomarker Identification Through Integrating the Gene Signatures of Hepatocellular Carcinoma Properties.
EBioMedicine1918-30(2017 May)
Cai J,Li B,Zhu Y,Fang X,Zhu M,Wang M,Liu S,Jiang X,Zheng J,Zhang X,Chen P

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RAD21 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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