| Gene Symbol | POLD4 |
| Entrez Gene ID | 57804 |
| Full Name | DNA polymerase delta 4, accessory subunit |
| Synonyms | POLDS,p12 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]. |
| Disorder MIM: |
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POLD4 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following POLD4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the POLD4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu10809 Clone ID Related Accession (Same CDS sequence) NM_001256870.1 Accession Version NM_001256870.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 240bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1570550400000 Organism Homo sapiens(human) Product DNA polymerase delta subunit 4 isoform 2 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM697399.1, BG576821.1, BG403692.1 and AP003419.3. Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG403692.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181ATGGGCCGGA AGCGGCTCAT CACTGATTCC TACCCGGTTG TGAAGAGGAG GGAGGGGCCC
GCTGGGCACA GCAAGGGGGA GCTGGCACCC GAGCTAGGGG AGGAGCCCCA GCCCCGCGAC
GAGGAGGAAG CGGAGCTGGA GCTGCTGAGG CAGTTTGACC TGGCCTGGCA GTACGGGCCC
TGCACCGTCT CTGGCATCTC TATCCCCTAT GAGGCACCAC GTAAGACCTC CTGCCCTTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001243799.1 CDS 198..437 Translation 
Target ORF information:
RefSeq Version NM_001256870.1 Organism Homo sapiens(human) Definition Homo sapiens DNA polymerase delta 4, accessory subunit (POLD4), transcript variant 2, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_001256870.1
ORF Insert Sequence:
1
61
121
181ATGGGCCGGA AGCGGCTCAT CACTGATTCC TACCCGGTTG TGAAGAGGAG GGAGGGGCCC
GCTGGGCACA GCAAGGGGGA GCTGGCACCC GAGCTAGGGG AGGAGCCCCA GCCCCGCGAC
GAGGAGGAAG CGGAGCTGGA GCTGCTGAGG CAGTTTGACC TGGCCTGGCA GTACGGGCCC
TGCACCGTCT CTGGCATCTC TATCCCCTAT GAGGCACCAC GTAAGACCTC CTGCCCTTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu11766 Clone ID Related Accession (Same CDS sequence) NM_021173.4 , NM_021173.5 Accession Version NM_021173.4 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 324bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1506873600000 Organism Homo sapiens(human) Product DNA polymerase delta subunit 4 isoform 1 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM697399.1, BC070250.1, AF179890.1 and AP003419.3. On Mar 2, 2012 this sequence version replaced NM_021173.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC070250.1, SRR1163657.529253.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301ATGGGCCGGA AGCGGCTCAT CACTGATTCC TACCCGGTTG TGAAGAGGAG GGAGGGGCCC
GCTGGGCACA GCAAGGGGGA GCTGGCACCC GAGCTAGGGG AGGAGCCCCA GCCCCGCGAC
GAGGAGGAAG CGGAGCTGGA GCTGCTGAGG CAGTTTGACC TGGCCTGGCA GTACGGGCCC
TGCACCGGGA TCACACGGCT GCAGCGCTGG TGTCGGGCCA AGCAGATGGG CTTGGAGCCT
CCCCCAGAGG TGTGGCAGGT GCTGAAGACC CACCCCGGAG ACCCCCGCTT CCAGTGCAGT
CTCTGGCATC TCTATCCCCT ATGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_066996.3 CDS 198..521 Translation
Target ORF information:
RefSeq Version NM_021173.4 Organism Homo sapiens(human) Definition Homo sapiens DNA polymerase delta 4, accessory subunit (POLD4), transcript variant 1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_021173.4
ORF Insert Sequence:
1
61
121
181
241
301ATGGGCCGGA AGCGGCTCAT CACTGATTCC TACCCGGTTG TGAAGAGGAG GGAGGGGCCC
GCTGGGCACA GCAAGGGGGA GCTGGCACCC GAGCTAGGGG AGGAGCCCCA GCCCCGCGAC
GAGGAGGAAG CGGAGCTGGA GCTGCTGAGG CAGTTTGACC TGGCCTGGCA GTACGGGCCC
TGCACCGGGA TCACACGGCT GCAGCGCTGG TGTCGGGCCA AGCAGATGGG CTTGGAGCCT
CCCCCAGAGG TGTGGCAGGT GCTGAAGACC CACCCCGGAG ACCCCCGCTT CCAGTGCAGT
CTCTGGCATC TCTATCCCCT ATGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu11766 Clone ID Related Accession (Same CDS sequence) NM_021173.4 , NM_021173.5 Accession Version NM_021173.5 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 324bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1570550400000 Organism Homo sapiens(human) Product DNA polymerase delta subunit 4 isoform 1 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC070250.1, AF179890.1 and AP003419.3. On Nov 23, 2018 this sequence version replaced NM_021173.4. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC070250.1, SRR3476690.800184.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000312419.8/ ENSP00000311368.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301ATGGGCCGGA AGCGGCTCAT CACTGATTCC TACCCGGTTG TGAAGAGGAG GGAGGGGCCC
GCTGGGCACA GCAAGGGGGA GCTGGCACCC GAGCTAGGGG AGGAGCCCCA GCCCCGCGAC
GAGGAGGAAG CGGAGCTGGA GCTGCTGAGG CAGTTTGACC TGGCCTGGCA GTACGGGCCC
TGCACCGGGA TCACACGGCT GCAGCGCTGG TGTCGGGCCA AGCAGATGGG CTTGGAGCCT
CCCCCAGAGG TGTGGCAGGT GCTGAAGACC CACCCCGGAG ACCCCCGCTT CCAGTGCAGT
CTCTGGCATC TCTATCCCCT ATGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_066996.3 CDS 148..471 Translation
Target ORF information:
RefSeq Version NM_021173.5 Organism Homo sapiens(human) Definition Homo sapiens DNA polymerase delta 4, accessory subunit (POLD4), transcript variant 1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_021173.5
ORF Insert Sequence:
1
61
121
181
241
301ATGGGCCGGA AGCGGCTCAT CACTGATTCC TACCCGGTTG TGAAGAGGAG GGAGGGGCCC
GCTGGGCACA GCAAGGGGGA GCTGGCACCC GAGCTAGGGG AGGAGCCCCA GCCCCGCGAC
GAGGAGGAAG CGGAGCTGGA GCTGCTGAGG CAGTTTGACC TGGCCTGGCA GTACGGGCCC
TGCACCGGGA TCACACGGCT GCAGCGCTGG TGTCGGGCCA AGCAGATGGG CTTGGAGCCT
CCCCCAGAGG TGTGGCAGGT GCTGAAGACC CACCCCGGAG ACCCCCGCTT CCAGTGCAGT
CTCTGGCATC TCTATCCCCT ATGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M
The tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression.
Cell cycle (Georgetown, Tex.)13(1)23-31(2014)
Lee MY,Zhang S,Lin SH,Wang X,Darzynkiewicz Z,Zhang Z,Lee EY
Proteolysis of the human DNA polymerase delta smallest subunit p12 by μ-calpain in calcium-triggered apoptotic HeLa cells.
PloS one9(4)e93642(2014)
Fan X,Zhang Q,You C,Qian Y,Gao J,Liu P,Chen H,Song H,Chen Y,Chen K,Zhou Y
Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase δ.
DNA repair12(11)922-35(2013 Nov)
Lin SH,Wang X,Zhang S,Zhang Z,Lee EY,Lee MY
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