| Gene Symbol | EXOSC5 |
| Entrez Gene ID | 56915 |
| Full Name | exosome component 5 |
| Synonyms | RRP41B,RRP46,Rrp46p,hRrp46p,p12B |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Disorder MIM: |
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EXOSC5 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following EXOSC5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EXOSC5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu03225 Clone ID Related Accession (Same CDS sequence) NM_020158.4 , NM_020158.3 Accession Version NM_020158.4 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 708bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1574611200000 Organism Homo sapiens(human) Product exosome complex component RRP46 Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC011462.4 and AF281134.1. On Nov 23, 2018 this sequence version replaced NM_020158.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF285785.1, SRR5189658.209245.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000221233.9/ ENSP00000221233.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541
601
661ATGGAGGAGG AGACGCATAC TGACGCCAAA ATCCGTGCTG AAAATGGAAC AGGGTCCAGC
CCTCGGGGTC CTGGCTGCAG CCTCCGGCAC TTTGCCTGCG AACAGAACCT GCTGTCGCGG
CCAGATGGCT CTGCTTCCTT CCTGCAAGGT GACACCTCTG TCCTGGCGGG TGTGTACGGG
CCGGCCGAGG TGAAGGTCAG CAAAGAGATT TTCAACAAGG CCACACTCGA AGTGATCCTG
AGGCCGAAGA TTGGGCTGCC TGGTGTTGCA GAGAAGAGCC GGGAGCGGCT GATCAGGAAC
ACGTGCGAGG CGGTGGTGCT GGGCACGTTG CACCCCCGCA CCTCCATCAC CGTGGTGCTG
CAGGTTGTCA GCGATGCCGG CTCTCTCCTG GCCTGTTGTC TGAATGCCGC CTGCATGGCA
TTGGTGGATG CAGGTGTGCC CATGCGGGCT CTCTTCTGTG GGGTCGCCTG CGCCCTGGAC
TCTGATGGGA CCCTCGTGCT GGATCCTACA TCCAAGCAAG AAAAGGAGGC CCGGGCAGTC
CTGACCTTTG CCCTGGACAG CGTGGAACGG AAGCTGCTGA TGTCCAGCAC CAAGGGGCTC
TACTCAGACA CTGAGCTCCA GCAGTGCCTG GCTGCGGCCC AGGCCGCTTC GCAACACGTC
TTCCGTTTCT ACCGGGAATC GCTGCAGAGG CGTTACTCCA AGAGCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_064543.3 CDS 32..739 Translation 
Target ORF information:
RefSeq Version NM_020158.4 Organism Homo sapiens(human) Definition Homo sapiens exosome component 5 (EXOSC5), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_020158.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661ATGGAGGAGG AGACGCATAC TGACGCCAAA ATCCGTGCTG AAAATGGAAC AGGGTCCAGC
CCTCGGGGTC CTGGCTGCAG CCTCCGGCAC TTTGCCTGCG AACAGAACCT GCTGTCGCGG
CCAGATGGCT CTGCTTCCTT CCTGCAAGGT GACACCTCTG TCCTGGCGGG TGTGTACGGG
CCGGCCGAGG TGAAGGTCAG CAAAGAGATT TTCAACAAGG CCACACTCGA AGTGATCCTG
AGGCCGAAGA TTGGGCTGCC TGGTGTTGCA GAGAAGAGCC GGGAGCGGCT GATCAGGAAC
ACGTGCGAGG CGGTGGTGCT GGGCACGTTG CACCCCCGCA CCTCCATCAC CGTGGTGCTG
CAGGTTGTCA GCGATGCCGG CTCTCTCCTG GCCTGTTGTC TGAATGCCGC CTGCATGGCA
TTGGTGGATG CAGGTGTGCC CATGCGGGCT CTCTTCTGTG GGGTCGCCTG CGCCCTGGAC
TCTGATGGGA CCCTCGTGCT GGATCCTACA TCCAAGCAAG AAAAGGAGGC CCGGGCAGTC
CTGACCTTTG CCCTGGACAG CGTGGAACGG AAGCTGCTGA TGTCCAGCAC CAAGGGGCTC
TACTCAGACA CTGAGCTCCA GCAGTGCCTG GCTGCGGCCC AGGCCGCTTC GCAACACGTC
TTCCGTTTCT ACCGGGAATC GCTGCAGAGG CGTTACTCCA AGAGCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu03225 Clone ID Related Accession (Same CDS sequence) NM_020158.4 , NM_020158.3 Accession Version NM_020158.3 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 708bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1506700800000 Organism Homo sapiens(human) Product exosome complex component RRP46 Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF281134.1 and BU683254.1. On May 14, 2004 this sequence version replaced NM_020158.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF281134.1, BC107696.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661ATGGAGGAGG AGACGCATAC TGACGCCAAA ATCCGTGCTG AAAATGGAAC AGGGTCCAGC
CCTCGGGGTC CTGGCTGCAG CCTCCGGCAC TTTGCCTGCG AACAGAACCT GCTGTCGCGG
CCAGATGGCT CTGCTTCCTT CCTGCAAGGT GACACCTCTG TCCTGGCGGG TGTGTACGGG
CCGGCCGAGG TGAAGGTCAG CAAAGAGATT TTCAACAAGG CCACACTCGA AGTGATCCTG
AGGCCGAAGA TTGGGCTGCC TGGTGTTGCA GAGAAGAGCC GGGAGCGGCT GATCAGGAAC
ACGTGCGAGG CGGTGGTGCT GGGCACGTTG CACCCCCGCA CCTCCATCAC CGTGGTGCTG
CAGGTTGTCA GCGATGCCGG CTCTCTCCTG GCCTGTTGTC TGAATGCCGC CTGCATGGCA
TTGGTGGATG CAGGTGTGCC CATGCGGGCT CTCTTCTGTG GGGTCGCCTG CGCCCTGGAC
TCTGATGGGA CCCTCGTGCT GGATCCTACA TCCAAGCAAG AAAAGGAGGC CCGGGCAGTC
CTGACCTTTG CCCTGGACAG CGTGGAACGG AAGCTGCTGA TGTCCAGCAC CAAGGGGCTC
TACTCAGACA CTGAGCTCCA GCAGTGCCTG GCTGCGGCCC AGGCCGCTTC GCAACACGTC
TTCCGTTTCT ACCGGGAATC GCTGCAGAGG CGTTACTCCA AGAGCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_064543.3 CDS 24..731 Translation
Target ORF information:
RefSeq Version NM_020158.3 Organism Homo sapiens(human) Definition Homo sapiens exosome component 5 (EXOSC5), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_020158.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661ATGGAGGAGG AGACGCATAC TGACGCCAAA ATCCGTGCTG AAAATGGAAC AGGGTCCAGC
CCTCGGGGTC CTGGCTGCAG CCTCCGGCAC TTTGCCTGCG AACAGAACCT GCTGTCGCGG
CCAGATGGCT CTGCTTCCTT CCTGCAAGGT GACACCTCTG TCCTGGCGGG TGTGTACGGG
CCGGCCGAGG TGAAGGTCAG CAAAGAGATT TTCAACAAGG CCACACTCGA AGTGATCCTG
AGGCCGAAGA TTGGGCTGCC TGGTGTTGCA GAGAAGAGCC GGGAGCGGCT GATCAGGAAC
ACGTGCGAGG CGGTGGTGCT GGGCACGTTG CACCCCCGCA CCTCCATCAC CGTGGTGCTG
CAGGTTGTCA GCGATGCCGG CTCTCTCCTG GCCTGTTGTC TGAATGCCGC CTGCATGGCA
TTGGTGGATG CAGGTGTGCC CATGCGGGCT CTCTTCTGTG GGGTCGCCTG CGCCCTGGAC
TCTGATGGGA CCCTCGTGCT GGATCCTACA TCCAAGCAAG AAAAGGAGGC CCGGGCAGTC
CTGACCTTTG CCCTGGACAG CGTGGAACGG AAGCTGCTGA TGTCCAGCAC CAAGGGGCTC
TACTCAGACA CTGAGCTCCA GCAGTGCCTG GCTGCGGCCC AGGCCGCTTC GCAACACGTC
TTCCGTTTCT ACCGGGAATC GCTGCAGAGG CGTTACTCCA AGAGCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Peroxiredoxin 1, a Novel HBx-Interacting Protein, Interacts with Exosome Component 5 and Negatively Regulates Hepatitis B Virus (HBV) Propagation through Degradation of HBV RNA.
Journal of virology93(6)(2019 03)
Deng L,Gan X,Ito M,Chen M,Aly HH,Matsui C,Abe T,Watashi K,Wakita T,Suzuki T,Okamoto T,Matsuura Y,Mizokami M,Shoji I,Hotta H
Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW
Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Molecular systems biology12(4)863(2016 Apr)
Yachie N,Petsalaki E,Mellor JC,Weile J,Jacob Y,Verby M,Ozturk SB,Li S,Cote AG,Mosca R,Knapp JJ,Ko M,Yu A,Gebbia M,Sahni N,Yi S,Tyagi T,Sheykhkarimli D,Roth JF,Wong C,Musa L,Snider J,Liu YC,Yu H,Braun P,Stagljar I,Hao T,Calderwood MA,Pelletier L,Aloy P,Hill DE,Vidal M,Roth FP
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M
Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA.
Nature511(7510)435-9(2014 Jul)
Wasmuth EV,Januszyk K,Lima CD
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