CMAS cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CMAS
Entrez Gene ID	55907
Full Name	cytidine monophosphate N-acetylneuraminic acid synthetase
Synonyms	CSS
General protein information	Preferred Names cytidine monophosphate N-acetylneuraminic acid synthetase Names N-acylneuraminate cytidylyltransferase CMP-N-acetylneuraminic acid synthase CMP-N-acetylneuraminic acid synthetase CMP-Neu5Ac synthetase CMP-NeuNAc synthase CMP-NeuNAc synthetase CMP-sialic acid synthetase cytidine 5'-monophosphate N-acetylneuraminic acid synthetase
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 12 Map Location: 12p12.1
Summary	This gene encodes an enzyme that converts N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc). This process is important in the formation of sialylated glycoprotein and glycolipids. This modification plays a role in cell-cell communications and immune responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Disorder MIM:	603316

mRNA and Protein(s)

mRNA	Protein	Name
NM_018686.6	NP_061156.1	N-acylneuraminate cytidylyltransferase
NM_018686.5	NP_061156.1	N-acylneuraminate cytidylyltransferase
NM_018686.4	NP_061156.1	N-acylneuraminate cytidylyltransferase

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	CMAS	XP_001099303.1
Mus musculus (house mouse)	Cmas	NP_034038.2
Danio rerio (zebrafish)	cmasb	NP_001245338.1
Rattus norvegicus (Norway rat)	Cmas	NP_001009419.1
Danio rerio (zebrafish)	cmasa	NP_001035342.2
Homo sapiens (human)	CMAS	NP_061156.1
Gallus gallus (chicken)	CMAS	XP_416429.1
Drosophila melanogaster (fruit fly)	Csas	NP_730474.1
Pan troglodytes (chimpanzee)	CMAS	XP_520794.2
Canis lupus familiaris (dog)	CMAS	XP_534866.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004527	XP_313827.5
Bos taurus (cattle)	CMAS	NP_001030475.1

Gene Ontology
Bibliography

Related articles in PubMed

CMP‑N‑acetylneuraminic acid synthetase interacts with fragile X related protein 1.
Ma Y, Tian S, Wang Z, Wang C, Chen X, Li W, Yang Y, He S
Molecular medicine reports14(2)1501-8(2016 Aug)

Haploid genetic screens in human cells identify host factors used by pathogens.
Carette JE, Guimaraes CP, Varadarajan M, Park AS, Wuethrich I, Godarova A, Kotecki M, Cochran BH, Spooner E, Ploegh HL, Brummelkamp TR
Science (New York, N.Y.)326(5957)1231-5(2009 Nov)

A C-terminal phosphatase module conserved in vertebrate CMP-sialic acid synthetases provides a tetramerization interface for the physiologically active enzyme.
Oschlies M, Dickmanns A, Haselhorst T, Schaper W, Stummeyer K, Tiralongo J, Weinhold B, Gerardy-Schahn R, von Itzstein M, Ficner R, Münster-Kühnel AK
Journal of molecular biology393(1)83-97(2009 Oct)

Nuclear localization signal of murine CMP-Neu5Ac synthetase includes residues required for both nuclear targeting and enzymatic activity.
Munster AK, Weinhold B, Gotza B, Muhlenhoff M, Frosch M, Gerardy-Schahn R
The Journal of biological chemistry277(22)19688-96(2002 May)

Cloning and expression of human sialic acid pathway genes to generate CMP-sialic acids in insect cells.
Lawrence SM, Huddleston KA, Tomiya N, Nguyen N, Lee YC, Vann WF, Coleman TA, Betenbaugh MJ
Glycoconjugate journal18(3)205-13(2001 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CMAS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CMAS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu56055	NM_018686.6 Latest version!	Homo sapiens cytidine monophosphate N-acetylneuraminic acid synthetase (CMAS), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$251.30 $359.00
View Old Accession Versions >>
OHu56055	NM_018686.5	Homo sapiens cytidine monophosphate N-acetylneuraminic acid synthetase (CMAS), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$251.30 $359.00
OHu56055	NM_018686.4	Homo sapiens cytidine monophosphate N-acetylneuraminic acid synthetase (CMAS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$251.30 $359.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CMAS ( NM_018686.6 ) cDNA ORF clone, Homo sapiens(Human) -> NP_061156.1 Homo sapiens cytidine monophosphate N-acetylneuraminic acid synthetase (CMAS), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu56055
Clone ID Related Accession (Same CDS sequence)	NM_018686.6 , NM_018686.5 , NM_018686.4
Accession Version	NM_018686.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1305bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	N-acylneuraminate cytidylyltransferase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA344740.1, AL832975.1 and DB527942.1. On Nov 23, 2018 this sequence version replaced NM_018686.5. Transcript Variant: This variant (1) represents the longer transcript and encodes the protein. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.640875.1, SRR1660807.49931.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000229329.7/ ENSP00000229329.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACTCGG TGGAGAAGGG GGCCGCCACC TCCGTCTCCA ACCCGCGGGG GCGACCGTCC 
CGGGGCCGGC CGCCGAAGCT GCAGCGCAAC TCTCGCGGCG GCCAGGGCCG AGGTGTGGAG 
AAGCCCCCGC ACCTGGCAGC CCTAATTCTG GCCCGGGGAG GCAGCAAAGG CATCCCCCTG 
AAGAACATTA AGCACCTGGC GGGGGTCCCG CTCATTGGCT GGGTCCTGCG TGCGGCCCTG 
GATTCAGGGG CCTTCCAGAG TGTATGGGTT TCGACAGACC ATGATGAAAT TGAGAATGTG 
GCCAAACAAT TTGGTGCACA AGTTCATCGA AGAAGTTCTG AAGTTTCAAA AGACAGCTCT 
ACCTCACTAG ATGCCATCAT AGAATTTCTT AATTATCATA ATGAGGTTGA CATTGTAGGA 
AATATTCAAG CTACTTCTCC ATGTTTACAT CCTACTGATC TTCAAAAAGT TGCAGAAATG 
ATTCGAGAAG AAGGATATGA TTCTGTTTTC TCTGTTGTGA GACGCCATCA GTTTCGATGG 
AGTGAAATTC AGAAAGGAGT TCGTGAAGTG ACCGAACCTC TGAATTTAAA TCCAGCTAAA 
CGGCCTCGTC GACAAGACTG GGATGGAGAA TTATATGAAA ATGGCTCATT TTATTTTGCT 
AAAAGACATT TGATAGAGAT GGGTTACTTG CAGGGTGGAA AAATGGCATA CTACGAAATG 
CGAGCTGAAC ATAGTGTGGA TATAGATGTG GATATTGATT GGCCTATTGC AGAGCAAAGA 
GTATTAAGAT ATGGCTATTT TGGCAAAGAG AAGCTTAAGG AAATAAAACT TTTGGTTTGC 
AATATTGATG GATGTCTCAC CAATGGCCAC ATTTATGTAT CAGGAGACCA AAAAGAAATA 
ATATCTTATG ATGTAAAAGA TGCTATTGGG ATAAGTTTAT TAAAGAAAAG TGGTATTGAG 
GTGAGGCTAA TCTCAGAAAG GGCCTGTTCA AAGCAGACGC TGTCTTCTTT AAAACTGGAT 
TGCAAAATGG AAGTCAGTGT ATCAGACAAG CTAGCAGTTG TAGATGAATG GAGAAAAGAA 
ATGGGCCTGT GCTGGAAAGA AGTGGCATAT CTTGGAAATG AAGTGTCTGA TGAAGAGTGC 
TTGAAGAGAG TGGGCCTAAG TGGCGCTCCT GCTGATGCCT GTTCTACTGC CCAGAAGGCT 
GTTGGATACA TTTGCAAATG TAATGGTGGC CGTGGTGCCA TCCGAGAATT TGCAGAGCAC 
ATTTGCCTAC TAATGGAAAA GGTTAATAAT TCATGCCAAA AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061156.1
CDS	87..1391
Translation	MDSVEKGAATSVSNPRGRPSRGRPPKLQRNSRGGQGRGVEKPPHLAALILARGGSKGIPLKNIKHLAGVPLIGWVLRAALDSGAFQSVWVSTDHDEIENVAKQFGAQVHRRSSEVSKDSSTSLDAIIEFLNYHNEVDIVGNIQATSPCLHPTDLQKVAEMIREEGYDSVFSVVRRHQFRWSEIQKGVREVTEPLNLNPAKRPRRQDWDGELYENGSFYFAKRHLIEMGYLQGGKMAYYEMRAEHSVDIDVDIDWPIAEQRVLRYGYFGKEKLKEIKLLVCNIDGCLTNGHIYVSGDQKEIISYDVKDAIGISLLKKSGIEVRLISERACSKQTLSSLKLDCKMEVSVSDKLAVVDEWRKEMGLCWKEVAYLGNEVSDEECLKRVGLSGAPADACSTAQKAVGYICKCNGGRGAIREFAEHICLLMEKVNNSCQK

Target ORF information:

RefSeq Version	NM_018686.6
Organism	Homo sapiens(human)
Definition	Homo sapiens cytidine monophosphate N-acetylneuraminic acid synthetase (CMAS), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018686.6

ORF Insert Sequence:

ATGGACTCGG TGGAGAAGGG GGCCGCCACC TCCGTCTCCA ACCCGCGGGG GCGACCGTCC 
CGGGGCCGGC CGCCGAAGCT GCAGCGCAAC TCTCGCGGCG GCCAGGGCCG AGGTGTGGAG 
AAGCCCCCGC ACCTGGCAGC CCTAATTCTG GCCCGGGGAG GCAGCAAAGG CATCCCCCTG 
AAGAACATTA AGCACCTGGC GGGGGTCCCG CTCATTGGCT GGGTCCTGCG TGCGGCCCTG 
GATTCAGGGG CCTTCCAGAG TGTATGGGTT TCGACAGACC ATGATGAAAT TGAGAATGTG 
GCCAAACAAT TTGGTGCACA AGTTCATCGA AGAAGTTCTG AAGTTTCAAA AGACAGCTCT 
ACCTCACTAG ATGCCATCAT AGAATTTCTT AATTATCATA ATGAGGTTGA CATTGTAGGA 
AATATTCAAG CTACTTCTCC ATGTTTACAT CCTACTGATC TTCAAAAAGT TGCAGAAATG 
ATTCGAGAAG AAGGATATGA TTCTGTTTTC TCTGTTGTGA GACGCCATCA GTTTCGATGG 
AGTGAAATTC AGAAAGGAGT TCGTGAAGTG ACCGAACCTC TGAATTTAAA TCCAGCTAAA 
CGGCCTCGTC GACAAGACTG GGATGGAGAA TTATATGAAA ATGGCTCATT TTATTTTGCT 
AAAAGACATT TGATAGAGAT GGGTTACTTG CAGGGTGGAA AAATGGCATA CTACGAAATG 
CGAGCTGAAC ATAGTGTGGA TATAGATGTG GATATTGATT GGCCTATTGC AGAGCAAAGA 
GTATTAAGAT ATGGCTATTT TGGCAAAGAG AAGCTTAAGG AAATAAAACT TTTGGTTTGC 
AATATTGATG GATGTCTCAC CAATGGCCAC ATTTATGTAT CAGGAGACCA AAAAGAAATA 
ATATCTTATG ATGTAAAAGA TGCTATTGGG ATAAGTTTAT TAAAGAAAAG TGGTATTGAG 
GTGAGGCTAA TCTCAGAAAG GGCCTGTTCA AAGCAGACGC TGTCTTCTTT AAAACTGGAT 
TGCAAAATGG AAGTCAGTGT ATCAGACAAG CTAGCAGTTG TAGATGAATG GAGAAAAGAA 
ATGGGCCTGT GCTGGAAAGA AGTGGCATAT CTTGGAAATG AAGTGTCTGA TGAAGAGTGC 
TTGAAGAGAG TGGGCCTAAG TGGCGCTCCT GCTGATGCCT GTTCTACTGC CCAGAAGGCT 
GTTGGATACA TTTGCAAATG TAATGGTGGC CGTGGTGCCA TCCGAGAATT TGCAGAGCAC 
ATTTGCCTAC TAATGGAAAA GGTTAATAAT TCATGCCAAA AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CMAS ( NM_018686.5 ) cDNA ORF clone, Homo sapiens(Human) -> NP_061156.1 Homo sapiens cytidine monophosphate N-acetylneuraminic acid synthetase (CMAS), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu56055
Clone ID Related Accession (Same CDS sequence)	NM_018686.6 , NM_018686.5 , NM_018686.4
Accession Version	NM_018686.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1305bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506873600000
Organism	Homo sapiens(human)
Product	N-acylneuraminate cytidylyltransferase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA344740.1, AL832975.1 and DB527942.1. On Feb 6, 2016 this sequence version replaced NM_018686.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the protein. ##Evidence-Data-START## Transcript exon combination :: AL832975.1, SRR1803614.46100.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACTCGG TGGAGAAGGG GGCCGCCACC TCCGTCTCCA ACCCGCGGGG GCGACCGTCC 
CGGGGCCGGC CGCCGAAGCT GCAGCGCAAC TCTCGCGGCG GCCAGGGCCG AGGTGTGGAG 
AAGCCCCCGC ACCTGGCAGC CCTAATTCTG GCCCGGGGAG GCAGCAAAGG CATCCCCCTG 
AAGAACATTA AGCACCTGGC GGGGGTCCCG CTCATTGGCT GGGTCCTGCG TGCGGCCCTG 
GATTCAGGGG CCTTCCAGAG TGTATGGGTT TCGACAGACC ATGATGAAAT TGAGAATGTG 
GCCAAACAAT TTGGTGCACA AGTTCATCGA AGAAGTTCTG AAGTTTCAAA AGACAGCTCT 
ACCTCACTAG ATGCCATCAT AGAATTTCTT AATTATCATA ATGAGGTTGA CATTGTAGGA 
AATATTCAAG CTACTTCTCC ATGTTTACAT CCTACTGATC TTCAAAAAGT TGCAGAAATG 
ATTCGAGAAG AAGGATATGA TTCTGTTTTC TCTGTTGTGA GACGCCATCA GTTTCGATGG 
AGTGAAATTC AGAAAGGAGT TCGTGAAGTG ACCGAACCTC TGAATTTAAA TCCAGCTAAA 
CGGCCTCGTC GACAAGACTG GGATGGAGAA TTATATGAAA ATGGCTCATT TTATTTTGCT 
AAAAGACATT TGATAGAGAT GGGTTACTTG CAGGGTGGAA AAATGGCATA CTACGAAATG 
CGAGCTGAAC ATAGTGTGGA TATAGATGTG GATATTGATT GGCCTATTGC AGAGCAAAGA 
GTATTAAGAT ATGGCTATTT TGGCAAAGAG AAGCTTAAGG AAATAAAACT TTTGGTTTGC 
AATATTGATG GATGTCTCAC CAATGGCCAC ATTTATGTAT CAGGAGACCA AAAAGAAATA 
ATATCTTATG ATGTAAAAGA TGCTATTGGG ATAAGTTTAT TAAAGAAAAG TGGTATTGAG 
GTGAGGCTAA TCTCAGAAAG GGCCTGTTCA AAGCAGACGC TGTCTTCTTT AAAACTGGAT 
TGCAAAATGG AAGTCAGTGT ATCAGACAAG CTAGCAGTTG TAGATGAATG GAGAAAAGAA 
ATGGGCCTGT GCTGGAAAGA AGTGGCATAT CTTGGAAATG AAGTGTCTGA TGAAGAGTGC 
TTGAAGAGAG TGGGCCTAAG TGGCGCTCCT GCTGATGCCT GTTCTACTGC CCAGAAGGCT 
GTTGGATACA TTTGCAAATG TAATGGTGGC CGTGGTGCCA TCCGAGAATT TGCAGAGCAC 
ATTTGCCTAC TAATGGAAAA GGTTAATAAT TCATGCCAAA AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061156.1
CDS	131..1435
Translation	MDSVEKGAATSVSNPRGRPSRGRPPKLQRNSRGGQGRGVEKPPHLAALILARGGSKGIPLKNIKHLAGVPLIGWVLRAALDSGAFQSVWVSTDHDEIENVAKQFGAQVHRRSSEVSKDSSTSLDAIIEFLNYHNEVDIVGNIQATSPCLHPTDLQKVAEMIREEGYDSVFSVVRRHQFRWSEIQKGVREVTEPLNLNPAKRPRRQDWDGELYENGSFYFAKRHLIEMGYLQGGKMAYYEMRAEHSVDIDVDIDWPIAEQRVLRYGYFGKEKLKEIKLLVCNIDGCLTNGHIYVSGDQKEIISYDVKDAIGISLLKKSGIEVRLISERACSKQTLSSLKLDCKMEVSVSDKLAVVDEWRKEMGLCWKEVAYLGNEVSDEECLKRVGLSGAPADACSTAQKAVGYICKCNGGRGAIREFAEHICLLMEKVNNSCQK

Target ORF information:

RefSeq Version	NM_018686.5
Organism	Homo sapiens(human)
Definition	Homo sapiens cytidine monophosphate N-acetylneuraminic acid synthetase (CMAS), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018686.5

ORF Insert Sequence:

ATGGACTCGG TGGAGAAGGG GGCCGCCACC TCCGTCTCCA ACCCGCGGGG GCGACCGTCC 
CGGGGCCGGC CGCCGAAGCT GCAGCGCAAC TCTCGCGGCG GCCAGGGCCG AGGTGTGGAG 
AAGCCCCCGC ACCTGGCAGC CCTAATTCTG GCCCGGGGAG GCAGCAAAGG CATCCCCCTG 
AAGAACATTA AGCACCTGGC GGGGGTCCCG CTCATTGGCT GGGTCCTGCG TGCGGCCCTG 
GATTCAGGGG CCTTCCAGAG TGTATGGGTT TCGACAGACC ATGATGAAAT TGAGAATGTG 
GCCAAACAAT TTGGTGCACA AGTTCATCGA AGAAGTTCTG AAGTTTCAAA AGACAGCTCT 
ACCTCACTAG ATGCCATCAT AGAATTTCTT AATTATCATA ATGAGGTTGA CATTGTAGGA 
AATATTCAAG CTACTTCTCC ATGTTTACAT CCTACTGATC TTCAAAAAGT TGCAGAAATG 
ATTCGAGAAG AAGGATATGA TTCTGTTTTC TCTGTTGTGA GACGCCATCA GTTTCGATGG 
AGTGAAATTC AGAAAGGAGT TCGTGAAGTG ACCGAACCTC TGAATTTAAA TCCAGCTAAA 
CGGCCTCGTC GACAAGACTG GGATGGAGAA TTATATGAAA ATGGCTCATT TTATTTTGCT 
AAAAGACATT TGATAGAGAT GGGTTACTTG CAGGGTGGAA AAATGGCATA CTACGAAATG 
CGAGCTGAAC ATAGTGTGGA TATAGATGTG GATATTGATT GGCCTATTGC AGAGCAAAGA 
GTATTAAGAT ATGGCTATTT TGGCAAAGAG AAGCTTAAGG AAATAAAACT TTTGGTTTGC 
AATATTGATG GATGTCTCAC CAATGGCCAC ATTTATGTAT CAGGAGACCA AAAAGAAATA 
ATATCTTATG ATGTAAAAGA TGCTATTGGG ATAAGTTTAT TAAAGAAAAG TGGTATTGAG 
GTGAGGCTAA TCTCAGAAAG GGCCTGTTCA AAGCAGACGC TGTCTTCTTT AAAACTGGAT 
TGCAAAATGG AAGTCAGTGT ATCAGACAAG CTAGCAGTTG TAGATGAATG GAGAAAAGAA 
ATGGGCCTGT GCTGGAAAGA AGTGGCATAT CTTGGAAATG AAGTGTCTGA TGAAGAGTGC 
TTGAAGAGAG TGGGCCTAAG TGGCGCTCCT GCTGATGCCT GTTCTACTGC CCAGAAGGCT 
GTTGGATACA TTTGCAAATG TAATGGTGGC CGTGGTGCCA TCCGAGAATT TGCAGAGCAC 
ATTTGCCTAC TAATGGAAAA GGTTAATAAT TCATGCCAAA AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CMAS ( NM_018686.4 ) cDNA ORF clone, Homo sapiens(Human) -> NP_061156.1 Homo sapiens cytidine monophosphate N-acetylneuraminic acid synthetase (CMAS), mRNA.

Price & Availability↑

CloneID	OHu56055
Clone ID Related Accession (Same CDS sequence)	NM_018686.6 , NM_018686.5 , NM_018686.4
Accession Version	NM_018686.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1305bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1426262400000
Organism	Homo sapiens(Human)
Product	N-acylneuraminate cytidylyltransferase
Comment

ATGGACTCGG TGGAGAAGGG GGCCGCCACC TCCGTCTCCA ACCCGCGGGG GCGACCGTCC 
CGGGGCCGGC CGCCGAAGCT GCAGCGCAAC TCTCGCGGCG GCCAGGGCCG AGGTGTGGAG 
AAGCCCCCGC ACCTGGCAGC CCTAATTCTG GCCCGGGGAG GCAGCAAAGG CATCCCCCTG 
AAGAACATTA AGCACCTGGC GGGGGTCCCG CTCATTGGCT GGGTCCTGCG TGCGGCCCTG 
GATTCAGGGG CCTTCCAGAG TGTATGGGTT TCGACAGACC ATGATGAAAT TGAGAATGTG 
GCCAAACAAT TTGGTGCACA AGTTCATCGA AGAAGTTCTG AAGTTTCAAA AGACAGCTCT 
ACCTCACTAG ATGCCATCAT AGAATTTCTT AATTATCATA ATGAGGTTGA CATTGTAGGA 
AATATTCAAG CTACTTCTCC ATGTTTACAT CCTACTGATC TTCAAAAAGT TGCAGAAATG 
ATTCGAGAAG AAGGATATGA TTCTGTTTTC TCTGTTGTGA GACGCCATCA GTTTCGATGG 
AGTGAAATTC AGAAAGGAGT TCGTGAAGTG ACCGAACCTC TGAATTTAAA TCCAGCTAAA 
CGGCCTCGTC GACAAGACTG GGATGGAGAA TTATATGAAA ATGGCTCATT TTATTTTGCT 
AAAAGACATT TGATAGAGAT GGGTTACTTG CAGGGTGGAA AAATGGCATA CTACGAAATG 
CGAGCTGAAC ATAGTGTGGA TATAGATGTG GATATTGATT GGCCTATTGC AGAGCAAAGA 
GTATTAAGAT ATGGCTATTT TGGCAAAGAG AAGCTTAAGG AAATAAAACT TTTGGTTTGC 
AATATTGATG GATGTCTCAC CAATGGCCAC ATTTATGTAT CAGGAGACCA AAAAGAAATA 
ATATCTTATG ATGTAAAAGA TGCTATTGGG ATAAGTTTAT TAAAGAAAAG TGGTATTGAG 
GTGAGGCTAA TCTCAGAAAG GGCCTGTTCA AAGCAGACGC TGTCTTCTTT AAAACTGGAT 
TGCAAAATGG AAGTCAGTGT ATCAGACAAG CTAGCAGTTG TAGATGAATG GAGAAAAGAA 
ATGGGCCTGT GCTGGAAAGA AGTGGCATAT CTTGGAAATG AAGTGTCTGA TGAAGAGTGC 
TTGAAGAGAG TGGGCCTAAG TGGCGCTCCT GCTGATGCCT GTTCTACTGC CCAGAAGGCT 
GTTGGATACA TTTGCAAATG TAATGGTGGC CGTGGTGCCA TCCGAGAATT TGCAGAGCAC 
ATTTGCCTAC TAATGGAAAA GGTTAATAAT TCATGCCAAA AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_061156.1

Translation

MDSVEKGAATSVSNPRGRPSRGRPPKLQRNSRGGQGRGVEKPPHLAALILARGGSKGIPLKNIKHLAGVPLIGWVLRAALDSGAFQSVWVSTDHDEIENVAKQFGAQVHRRSSEVSKDSSTSLDAIIEFLNYHNEVDIVGNIQATSPCLHPTDLQKVAEMIREEGYDSVFSVVRRHQFRWSEIQKGVREVTEPLNLNPAKRPRRQDWDGELYENGSFYFAKRHLIEMGYLQGGKMAYYEMRAEHSVDIDVDIDWPIAEQRVLRYGYFGKEKLKEIKLLVCNIDGCLTNGHIYVSGDQKEIISYDVKDAIGISLLKKSGIEVRLISERACSKQTLSSLKLDCKMEVSVSDKLAVVDEWRKEMGLCWKEVAYLGNEVSDEECLKRVGLSGAPADACSTAQKAVGYICKCNGGRGAIREFAEHICLLMEKVNNSCQK

Target ORF information:

RefSeq Version	NM_018686.4
Organism	Homo sapiens(Human)
Definition	Homo sapiens cytidine monophosphate N-acetylneuraminic acid synthetase (CMAS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018686.4

ORF Insert Sequence:

ATGGACTCGG TGGAGAAGGG GGCCGCCACC TCCGTCTCCA ACCCGCGGGG GCGACCGTCC 
CGGGGCCGGC CGCCGAAGCT GCAGCGCAAC TCTCGCGGCG GCCAGGGCCG AGGTGTGGAG 
AAGCCCCCGC ACCTGGCAGC CCTAATTCTG GCCCGGGGAG GCAGCAAAGG CATCCCCCTG 
AAGAACATTA AGCACCTGGC GGGGGTCCCG CTCATTGGCT GGGTCCTGCG TGCGGCCCTG 
GATTCAGGGG CCTTCCAGAG TGTATGGGTT TCGACAGACC ATGATGAAAT TGAGAATGTG 
GCCAAACAAT TTGGTGCACA AGTTCATCGA AGAAGTTCTG AAGTTTCAAA AGACAGCTCT 
ACCTCACTAG ATGCCATCAT AGAATTTCTT AATTATCATA ATGAGGTTGA CATTGTAGGA 
AATATTCAAG CTACTTCTCC ATGTTTACAT CCTACTGATC TTCAAAAAGT TGCAGAAATG 
ATTCGAGAAG AAGGATATGA TTCTGTTTTC TCTGTTGTGA GACGCCATCA GTTTCGATGG 
AGTGAAATTC AGAAAGGAGT TCGTGAAGTG ACCGAACCTC TGAATTTAAA TCCAGCTAAA 
CGGCCTCGTC GACAAGACTG GGATGGAGAA TTATATGAAA ATGGCTCATT TTATTTTGCT 
AAAAGACATT TGATAGAGAT GGGTTACTTG CAGGGTGGAA AAATGGCATA CTACGAAATG 
CGAGCTGAAC ATAGTGTGGA TATAGATGTG GATATTGATT GGCCTATTGC AGAGCAAAGA 
GTATTAAGAT ATGGCTATTT TGGCAAAGAG AAGCTTAAGG AAATAAAACT TTTGGTTTGC 
AATATTGATG GATGTCTCAC CAATGGCCAC ATTTATGTAT CAGGAGACCA AAAAGAAATA 
ATATCTTATG ATGTAAAAGA TGCTATTGGG ATAAGTTTAT TAAAGAAAAG TGGTATTGAG 
GTGAGGCTAA TCTCAGAAAG GGCCTGTTCA AAGCAGACGC TGTCTTCTTT AAAACTGGAT 
TGCAAAATGG AAGTCAGTGT ATCAGACAAG CTAGCAGTTG TAGATGAATG GAGAAAAGAA 
ATGGGCCTGT GCTGGAAAGA AGTGGCATAT CTTGGAAATG AAGTGTCTGA TGAAGAGTGC 
TTGAAGAGAG TGGGCCTAAG TGGCGCTCCT GCTGATGCCT GTTCTACTGC CCAGAAGGCT 
GTTGGATACA TTTGCAAATG TAATGGTGGC CGTGGTGCCA TCCGAGAATT TGCAGAGCAC 
ATTTGCCTAC TAATGGAAAA GGTTAATAAT TCATGCCAAA AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CMP‑N‑acetylneuraminic acid synthetase interacts with fragile X related protein 1.
Molecular medicine reports14(2)1501-8(2016 Aug)
Ma Y,Tian S,Wang Z,Wang C,Chen X,Li W,Yang Y,He S

Haploid genetic screens in human cells identify host factors used by pathogens.
Science (New York, N.Y.)326(5957)1231-5(2009 Nov)
Carette JE,Guimaraes CP,Varadarajan M,Park AS,Wuethrich I,Godarova A,Kotecki M,Cochran BH,Spooner E,Ploegh HL,Brummelkamp TR

A C-terminal phosphatase module conserved in vertebrate CMP-sialic acid synthetases provides a tetramerization interface for the physiologically active enzyme.
Journal of molecular biology393(1)83-97(2009 Oct)
Oschlies M,Dickmanns A,Haselhorst T,Schaper W,Stummeyer K,Tiralongo J,Weinhold B,Gerardy-Schahn R,von Itzstein M,Ficner R,Münster-Kühnel AK

Nuclear localization signal of murine CMP-Neu5Ac synthetase includes residues required for both nuclear targeting and enzymatic activity.
The Journal of biological chemistry277(22)19688-96(2002 May)
Munster AK,Weinhold B,Gotza B,Muhlenhoff M,Frosch M,Gerardy-Schahn R

Cloning and expression of human sialic acid pathway genes to generate CMP-sialic acids in insect cells.
Glycoconjugate journal18(3)205-13(2001 Mar)
Lawrence SM,Huddleston KA,Tomiya N,Nguyen N,Lee YC,Vann WF,Coleman TA,Betenbaugh MJ

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CMAS cDNA ORF clone, Homo sapiens(Human)

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