PPP6C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PPP6C
Entrez Gene ID	5537
Full Name	protein phosphatase 6 catalytic subunit
Synonyms	PP6,PP6C
General protein information	Preferred Names protein phosphatase 6 catalytic subunit Names serine/threonine-protein phosphatase 6 catalytic subunit serine/threonine protein phosphatase catalytic subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q33.3
Summary	This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008].
Disorder MIM:	612725

mRNA and Protein(s)

mRNA	Protein	Name
XM_011518847.2	XP_011517149.1	serine/threonine-protein phosphatase 6 catalytic subunit isoform X1
NM_002721.4	NP_002712.1	serine/threonine-protein phosphatase 6 catalytic subunit isoform b
NM_001123355.1	NP_001116827.1	serine/threonine-protein phosphatase 6 catalytic subunit isoform a
XM_011518847.3	XP_011517149.1	serine/threonine-protein phosphatase 6 catalytic subunit isoform X1
XM_024447607.1	XP_024303375.1	serine/threonine-protein phosphatase 6 catalytic subunit isoform X2
NM_002721.5	NP_002712.1	serine/threonine-protein phosphatase 6 catalytic subunit isoform b
NM_001123369.1	NP_001116841.1	serine/threonine-protein phosphatase 6 catalytic subunit isoform c

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	ppp6c	NP_001017110.1
Drosophila melanogaster (fruit fly)	PpV	NP_001259274.1
Saccharomyces cerevisiae (baker's yeast)	SIT4	NP_010236.1
Kluyveromyces lactis	KLLA0D03652g	XP_453227.1
Magnaporthe oryzae (rice blast fungus)	MGG_03911	XP_003719961.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003017	XP_311859.5
Schizosaccharomyces pombe (fission yeast)	ppe1	NP_588420.1
Neurospora crassa	NCU03436	XP_956722.1
Homo sapiens (human)	PPP6C	NP_002712.1
Bos taurus (cattle)	PPP6C	NP_001124222.1
Rattus norvegicus (Norway rat)	Ppp6c	NP_598273.2
Gallus gallus (chicken)	PPP6C	NP_001073233.1
Caenorhabditis elegans (roundworm)	pph-6	NP_497714.2
Eremothecium gossypii	AGOS_AER202C	NP_985059.1
Canis lupus familiaris (dog)	PPP6C	XP_851294.2
Arabidopsis thaliana (thale cress)	AT1G50370	NP_175454.1
Pan troglodytes (chimpanzee)	PPP6C	XP_003312329.1
Danio rerio (zebrafish)	ppp6c	NP_957299.1
Oryza sativa (rice)	Os01g0691700	NP_001043937.1
Mus musculus (house mouse)	Ppp6c	NP_077171.1
Arabidopsis thaliana (thale cress)	FYPP3	NP_188632.1

Gene Ontology
Bibliography

Related articles in PubMed

Global assessment of its network dynamics reveals that the kinase Plk1 inhibits the phosphatase PP6 to promote Aurora A activity.
Kettenbach AN, Schlosser KA, Lyons SP, Nasa I, Gui J, Adamo ME, Gerber SA
Science signaling11(530)(2018 05)

A PP6-ASK3 Module Coordinates the Bidirectional Cell Volume Regulation under Osmotic Stress.
Watanabe K, Umeda T, Niwa K, Naguro I, Ichijo H
Cell reports22(11)2809-2817(2018 03)

Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling.
Tan P, He L, Cui J, Qian C, Cao X, Lin M, Zhu Q, Li Y, Xing C, Yu X, Wang HY, Wang RF
Molecular cell68(2)293-307.e5(2017 Oct)

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
Yadav L, Tamene F, Göös H, van Drogen A, Katainen R, Aebersold R, Gstaiger M, Varjosalo M
Cell systems4(4)430-444.e5(2017 04)

The three Type 2A protein phosphatases, PP2Ac, PP4c and PP6c, are differentially regulated by Alpha4.
LeNoue-Newton ML, Wadzinski BE, Spiller BW
Biochemical and biophysical research communications475(1)64-9(2016 06)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PPP6C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PPP6C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26810	NM_001123369.1 Latest version!	Homo sapiens protein phosphatase 6 catalytic subunit (PPP6C), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu106168	XM_024447607.1 Latest version!	Homo sapiens protein phosphatase 6 catalytic subunit (PPP6C), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu59890	XM_011518847.3 Latest version!	Homo sapiens protein phosphatase 6 catalytic subunit (PPP6C), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu26886	NM_001123355.1 Latest version!	Homo sapiens protein phosphatase 6 catalytic subunit (PPP6C), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$237.30 $339.00
OHu27203	NM_002721.5 Latest version!	Homo sapiens protein phosphatase 6 catalytic subunit (PPP6C), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$216.30 $309.00
View Old Accession Versions >>
OHu59890	XM_011518847.2	Homo sapiens protein phosphatase 6 catalytic subunit (PPP6C), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu27203	NM_002721.4	Homo sapiens protein phosphatase 6 catalytic subunit (PPP6C), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PPP6C ( NM_001123369.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001116841.1 Homo sapiens protein phosphatase 6 catalytic subunit (PPP6C), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu26810
Clone ID Related Accession (Same CDS sequence)	NM_001123369.1
Accession Version	NM_001123369.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 852bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571673600000
Organism	Homo sapiens(human)
Product	serine/threonine-protein phosphatase 6 catalytic subunit isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB037210.1, AL445930.11, DC307002.1, DC369815.1, BC006990.1, AA251321.1 and CB250498.1. Transcript Variant: This variant (3) lacks one coding exon compared to variant 1 and encodes isoform c, which is shorter than isoform a. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence and transcripts to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.174453.1, SRR1803611.153450.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCCGC TAGACCTGGA CAAGTATGTG GAAATAGCGC GGCTGTGCAA GTACCTGCCA 
GAGAACGACC TGAAGCGGCT ATGTGACTAC GTTTGTGACC TCCTCTTAGA AGAGTCAAAT 
GTTCAGCCAG TATCAACACC AGTAACAGTG TGTGGAGATA TCCATGGACA GGGTGATTTT 
GTAGACAGAG GTTACTATAG TTTGGAGACC TTCACTTACC TTCTTGCATT AAAGGCTAAA 
TGGCCTGATC GTATTACACT TTTGCGAGGA AATCATGAGA GTAGACAGAT AACACAGGTC 
TATGGATTTT ATGATGAGTG CCAAACCAAA TATGGAAATG CTAATGCCTG GAGATACTGT 
ACCAAAGTTT TTGACATGCT CACAGTAGCA GCTTTAATAG ATGAGCAGAT TTTGTGTGTC 
CATGGTGGTT TATCTCCTGA TATCAAAACA CTGGATCAAA TTCGAACCAT CGAACGGAAT 
CAGGAAATTC CTCATAAAGG AGCATTTTGT GATCTGGTTT GGTCAGATCC TGAAGATGTG 
GATACCTGGG CTATCAGTCC CCGAGGAGCA GGTTGGCTTT TTGGAGCAAA GGTCACAAAT 
GAGTTTGTTC ATATCAACAA CTTAAAACTC ATCTGCAGAG CACATCAACT AGTGCACGAA 
GGCTATAAAT TTATGTTTGA TGAGAAGCTG GTGACAGTAT GGTCTGCTCC TAATTACTGC 
TATCGTTGTG GAAATATTGC TTCGATCATG GTCTTCAAAG ATGTAAATAC AAGAGAACCA 
AAGTTATTCC GGGCAGTTCC AGATTCAGAA CGTGTTATTC CTCCCAGAAC GACAACGCCA 
TATTTCCTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001116841.1
CDS	222..1073
Translation	MAPLDLDKYVEIARLCKYLPENDLKRLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDSERVIPPRTTTPYFL

Target ORF information:

RefSeq Version	NM_001123369.1
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 6 catalytic subunit (PPP6C), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001123369.1

ORF Insert Sequence:

ATGGCGCCGC TAGACCTGGA CAAGTATGTG GAAATAGCGC GGCTGTGCAA GTACCTGCCA 
GAGAACGACC TGAAGCGGCT ATGTGACTAC GTTTGTGACC TCCTCTTAGA AGAGTCAAAT 
GTTCAGCCAG TATCAACACC AGTAACAGTG TGTGGAGATA TCCATGGACA GGGTGATTTT 
GTAGACAGAG GTTACTATAG TTTGGAGACC TTCACTTACC TTCTTGCATT AAAGGCTAAA 
TGGCCTGATC GTATTACACT TTTGCGAGGA AATCATGAGA GTAGACAGAT AACACAGGTC 
TATGGATTTT ATGATGAGTG CCAAACCAAA TATGGAAATG CTAATGCCTG GAGATACTGT 
ACCAAAGTTT TTGACATGCT CACAGTAGCA GCTTTAATAG ATGAGCAGAT TTTGTGTGTC 
CATGGTGGTT TATCTCCTGA TATCAAAACA CTGGATCAAA TTCGAACCAT CGAACGGAAT 
CAGGAAATTC CTCATAAAGG AGCATTTTGT GATCTGGTTT GGTCAGATCC TGAAGATGTG 
GATACCTGGG CTATCAGTCC CCGAGGAGCA GGTTGGCTTT TTGGAGCAAA GGTCACAAAT 
GAGTTTGTTC ATATCAACAA CTTAAAACTC ATCTGCAGAG CACATCAACT AGTGCACGAA 
GGCTATAAAT TTATGTTTGA TGAGAAGCTG GTGACAGTAT GGTCTGCTCC TAATTACTGC 
TATCGTTGTG GAAATATTGC TTCGATCATG GTCTTCAAAG ATGTAAATAC AAGAGAACCA 
AAGTTATTCC GGGCAGTTCC AGATTCAGAA CGTGTTATTC CTCCCAGAAC GACAACGCCA 
TATTTCCTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP6C ( XM_024447607.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024303375.1 Homo sapiens protein phosphatase 6 catalytic subunit (PPP6C), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu106168
Clone ID Related Accession (Same CDS sequence)	XM_024447607.1
Accession Version	XM_024447607.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 477bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	serine/threonine-protein phosphatase 6 catalytic subunit isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCACAG TAGCAGCTTT AATAGATGAG CAGATTTTGT GTGTCCATGG TGGTTTATCT 
CCTGATATCA AAACACTGGA TCAAATTCGA ACCATCGAAC GGAATCAGGA AATTCCTCAT 
AAAGGAGCAT TTTGTGATCT GGTTTGGTCA GATCCTGAAG ATGTGGATAC CTGGGCTATC 
AGTCCCCGAG GAGCAGGTTG GCTTTTTGGA GCAAAGGTCA CAAATGAGTT TGTTCATATC 
AACAACTTAA AACTCATCTG CAGAGCACAT CAACTAGTGC ACGAAGGCTA TAAATTTATG 
TTTGATGAGA AGCTGGTGAC AGTATGGTCT GCTCCTAATT ACTGCTATCG TTGTGGAAAT 
ATTGCTTCGA TCATGGTCTT CAAAGATGTA AATACAAGAG AACCAAAGTT ATTCCGGGCA 
GTTCCAGATT CAGAACGTGT TATTCCTCCC AGAACGACAA CGCCATATTT CCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024303375.1
CDS	316..792
Translation	MLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDSERVIPPRTTTPYFL

Target ORF information:

RefSeq Version	XM_024447607.1
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 6 catalytic subunit (PPP6C), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024447607.1

ORF Insert Sequence:

ATGCTCACAG TAGCAGCTTT AATAGATGAG CAGATTTTGT GTGTCCATGG TGGTTTATCT 
CCTGATATCA AAACACTGGA TCAAATTCGA ACCATCGAAC GGAATCAGGA AATTCCTCAT 
AAAGGAGCAT TTTGTGATCT GGTTTGGTCA GATCCTGAAG ATGTGGATAC CTGGGCTATC 
AGTCCCCGAG GAGCAGGTTG GCTTTTTGGA GCAAAGGTCA CAAATGAGTT TGTTCATATC 
AACAACTTAA AACTCATCTG CAGAGCACAT CAACTAGTGC ACGAAGGCTA TAAATTTATG 
TTTGATGAGA AGCTGGTGAC AGTATGGTCT GCTCCTAATT ACTGCTATCG TTGTGGAAAT 
ATTGCTTCGA TCATGGTCTT CAAAGATGTA AATACAAGAG AACCAAAGTT ATTCCGGGCA 
GTTCCAGATT CAGAACGTGT TATTCCTCCC AGAACGACAA CGCCATATTT CCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP6C ( XM_011518847.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011517149.1 Homo sapiens protein phosphatase 6 catalytic subunit (PPP6C), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu59890
Clone ID Related Accession (Same CDS sequence)	XM_011518847.2 , XM_011518847.3
Accession Version	XM_011518847.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 882bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1465056000000
Organism	Homo sapiens(human)
Product	serine/threonine-protein phosphatase 6 catalytic subunit isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011518847.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTTTTAT TGCCAAGACT ACAGTTGCTG GGTCAAATGC GGCTATGTGA CTACGTTTGT 
GACCTCCTCT TAGAAGAGTC AAATGTTCAG CCAGTATCAA CACCAGTAAC AGTGTGTGGA 
GATATCCATG GACAGTTTTA TGACCTTTGT GAACTGTTCA GAACTGGAGG TCAGGTTCCT 
GACACAAACT ACATATTTAT GGGTGATTTT GTAGACAGAG GTTACTATAG TTTGGAGACC 
TTCACTTACC TTCTTGCATT AAAGGCTAAA TGGCCTGATC GTATTACACT TTTGCGAGGA 
AATCATGAGA GTAGACAGAT AACACAGGTC TATGGATTTT ATGATGAGTG CCAAACCAAA 
TATGGAAATG CTAATGCCTG GAGATACTGT ACCAAAGTTT TTGACATGCT CACAGTAGCA 
GCTTTAATAG ATGAGCAGAT TTTGTGTGTC CATGGTGGTT TATCTCCTGA TATCAAAACA 
CTGGATCAAA TTCGAACCAT CGAACGGAAT CAGGAAATTC CTCATAAAGG AGCATTTTGT 
GATCTGGTTT GGTCAGATCC TGAAGATGTG GATACCTGGG CTATCAGTCC CCGAGGAGCA 
GGTTGGCTTT TTGGAGCAAA GGTCACAAAT GAGTTTGTTC ATATCAACAA CTTAAAACTC 
ATCTGCAGAG CACATCAACT AGTGCACGAA GGCTATAAAT TTATGTTTGA TGAGAAGCTG 
GTGACAGTAT GGTCTGCTCC TAATTACTGC TATCGTTGTG GAAATATTGC TTCGATCATG 
GTCTTCAAAG ATGTAAATAC AAGAGAACCA AAGTTATTCC GGGCAGTTCC AGATTCAGAA 
CGTGTTATTC CTCCCAGAAC GACAACGCCA TATTTCCTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011517149.1
CDS	55..936
Translation	MFLLPRLQLLGQMRLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDSERVIPPRTTTPYFL

Target ORF information:

RefSeq Version	XM_011518847.2
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 6 catalytic subunit (PPP6C), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011518847.2

ORF Insert Sequence:

ATGTTTTTAT TGCCAAGACT ACAGTTGCTG GGTCAAATGC GGCTATGTGA CTACGTTTGT 
GACCTCCTCT TAGAAGAGTC AAATGTTCAG CCAGTATCAA CACCAGTAAC AGTGTGTGGA 
GATATCCATG GACAGTTTTA TGACCTTTGT GAACTGTTCA GAACTGGAGG TCAGGTTCCT 
GACACAAACT ACATATTTAT GGGTGATTTT GTAGACAGAG GTTACTATAG TTTGGAGACC 
TTCACTTACC TTCTTGCATT AAAGGCTAAA TGGCCTGATC GTATTACACT TTTGCGAGGA 
AATCATGAGA GTAGACAGAT AACACAGGTC TATGGATTTT ATGATGAGTG CCAAACCAAA 
TATGGAAATG CTAATGCCTG GAGATACTGT ACCAAAGTTT TTGACATGCT CACAGTAGCA 
GCTTTAATAG ATGAGCAGAT TTTGTGTGTC CATGGTGGTT TATCTCCTGA TATCAAAACA 
CTGGATCAAA TTCGAACCAT CGAACGGAAT CAGGAAATTC CTCATAAAGG AGCATTTTGT 
GATCTGGTTT GGTCAGATCC TGAAGATGTG GATACCTGGG CTATCAGTCC CCGAGGAGCA 
GGTTGGCTTT TTGGAGCAAA GGTCACAAAT GAGTTTGTTC ATATCAACAA CTTAAAACTC 
ATCTGCAGAG CACATCAACT AGTGCACGAA GGCTATAAAT TTATGTTTGA TGAGAAGCTG 
GTGACAGTAT GGTCTGCTCC TAATTACTGC TATCGTTGTG GAAATATTGC TTCGATCATG 
GTCTTCAAAG ATGTAAATAC AAGAGAACCA AAGTTATTCC GGGCAGTTCC AGATTCAGAA 
CGTGTTATTC CTCCCAGAAC GACAACGCCA TATTTCCTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP6C ( XM_011518847.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011517149.1 Homo sapiens protein phosphatase 6 catalytic subunit (PPP6C), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu59890
Clone ID Related Accession (Same CDS sequence)	XM_011518847.2 , XM_011518847.3
Accession Version	XM_011518847.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 882bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	serine/threonine-protein phosphatase 6 catalytic subunit isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011518847.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTTTTAT TGCCAAGACT ACAGTTGCTG GGTCAAATGC GGCTATGTGA CTACGTTTGT 
GACCTCCTCT TAGAAGAGTC AAATGTTCAG CCAGTATCAA CACCAGTAAC AGTGTGTGGA 
GATATCCATG GACAGTTTTA TGACCTTTGT GAACTGTTCA GAACTGGAGG TCAGGTTCCT 
GACACAAACT ACATATTTAT GGGTGATTTT GTAGACAGAG GTTACTATAG TTTGGAGACC 
TTCACTTACC TTCTTGCATT AAAGGCTAAA TGGCCTGATC GTATTACACT TTTGCGAGGA 
AATCATGAGA GTAGACAGAT AACACAGGTC TATGGATTTT ATGATGAGTG CCAAACCAAA 
TATGGAAATG CTAATGCCTG GAGATACTGT ACCAAAGTTT TTGACATGCT CACAGTAGCA 
GCTTTAATAG ATGAGCAGAT TTTGTGTGTC CATGGTGGTT TATCTCCTGA TATCAAAACA 
CTGGATCAAA TTCGAACCAT CGAACGGAAT CAGGAAATTC CTCATAAAGG AGCATTTTGT 
GATCTGGTTT GGTCAGATCC TGAAGATGTG GATACCTGGG CTATCAGTCC CCGAGGAGCA 
GGTTGGCTTT TTGGAGCAAA GGTCACAAAT GAGTTTGTTC ATATCAACAA CTTAAAACTC 
ATCTGCAGAG CACATCAACT AGTGCACGAA GGCTATAAAT TTATGTTTGA TGAGAAGCTG 
GTGACAGTAT GGTCTGCTCC TAATTACTGC TATCGTTGTG GAAATATTGC TTCGATCATG 
GTCTTCAAAG ATGTAAATAC AAGAGAACCA AAGTTATTCC GGGCAGTTCC AGATTCAGAA 
CGTGTTATTC CTCCCAGAAC GACAACGCCA TATTTCCTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011517149.1
CDS	463..1344
Translation	MFLLPRLQLLGQMRLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDSERVIPPRTTTPYFL

Target ORF information:

RefSeq Version	XM_011518847.3
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 6 catalytic subunit (PPP6C), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011518847.3

ORF Insert Sequence:

ATGTTTTTAT TGCCAAGACT ACAGTTGCTG GGTCAAATGC GGCTATGTGA CTACGTTTGT 
GACCTCCTCT TAGAAGAGTC AAATGTTCAG CCAGTATCAA CACCAGTAAC AGTGTGTGGA 
GATATCCATG GACAGTTTTA TGACCTTTGT GAACTGTTCA GAACTGGAGG TCAGGTTCCT 
GACACAAACT ACATATTTAT GGGTGATTTT GTAGACAGAG GTTACTATAG TTTGGAGACC 
TTCACTTACC TTCTTGCATT AAAGGCTAAA TGGCCTGATC GTATTACACT TTTGCGAGGA 
AATCATGAGA GTAGACAGAT AACACAGGTC TATGGATTTT ATGATGAGTG CCAAACCAAA 
TATGGAAATG CTAATGCCTG GAGATACTGT ACCAAAGTTT TTGACATGCT CACAGTAGCA 
GCTTTAATAG ATGAGCAGAT TTTGTGTGTC CATGGTGGTT TATCTCCTGA TATCAAAACA 
CTGGATCAAA TTCGAACCAT CGAACGGAAT CAGGAAATTC CTCATAAAGG AGCATTTTGT 
GATCTGGTTT GGTCAGATCC TGAAGATGTG GATACCTGGG CTATCAGTCC CCGAGGAGCA 
GGTTGGCTTT TTGGAGCAAA GGTCACAAAT GAGTTTGTTC ATATCAACAA CTTAAAACTC 
ATCTGCAGAG CACATCAACT AGTGCACGAA GGCTATAAAT TTATGTTTGA TGAGAAGCTG 
GTGACAGTAT GGTCTGCTCC TAATTACTGC TATCGTTGTG GAAATATTGC TTCGATCATG 
GTCTTCAAAG ATGTAAATAC AAGAGAACCA AAGTTATTCC GGGCAGTTCC AGATTCAGAA 
CGTGTTATTC CTCCCAGAAC GACAACGCCA TATTTCCTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP6C ( NM_001123355.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001116827.1 Homo sapiens protein phosphatase 6 catalytic subunit (PPP6C), transcript variant 1, mRNA.

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CloneID	OHu26886
Clone ID Related Accession (Same CDS sequence)	NM_001123355.1
Accession Version	NM_001123355.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1029bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571500800000
Organism	Homo sapiens(human)
Product	serine/threonine-protein phosphatase 6 catalytic subunit isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB037210.1, AL445930.11, DC334216.1, BC006990.1, AA251321.1 and CB250498.1. Transcript Variant: This variant (1) is the longest transcript; it encodes the longest isoform (a). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence and transcripts to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.114506.1, SRR1803617.85459.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCCGC TAGACCTGGA CAAGTATGTG GAAATAGCGC GGCTGTGCAA GTACCTGCCA 
GAGAACGACC TGAAGGTGAG CCCTATTTGC GGGCTCGCCC CTTCCGGCTG TGGGGCGCCC 
GCCGGCCGGC CCTTCCTTTC TCCAGGACCC CCGCCGGTAT TTCATTTTCT TCGTTTTCTA 
AAGGAGCGGC TATGTGACTA CGTTTGTGAC CTCCTCTTAG AAGAGTCAAA TGTTCAGCCA 
GTATCAACAC CAGTAACAGT GTGTGGAGAT ATCCATGGAC AGTTTTATGA CCTTTGTGAA 
CTGTTCAGAA CTGGAGGTCA GGTTCCTGAC ACAAACTACA TATTTATGGG TGATTTTGTA 
GACAGAGGTT ACTATAGTTT GGAGACCTTC ACTTACCTTC TTGCATTAAA GGCTAAATGG 
CCTGATCGTA TTACACTTTT GCGAGGAAAT CATGAGAGTA GACAGATAAC ACAGGTCTAT 
GGATTTTATG ATGAGTGCCA AACCAAATAT GGAAATGCTA ATGCCTGGAG ATACTGTACC 
AAAGTTTTTG ACATGCTCAC AGTAGCAGCT TTAATAGATG AGCAGATTTT GTGTGTCCAT 
GGTGGTTTAT CTCCTGATAT CAAAACACTG GATCAAATTC GAACCATCGA ACGGAATCAG 
GAAATTCCTC ATAAAGGAGC ATTTTGTGAT CTGGTTTGGT CAGATCCTGA AGATGTGGAT 
ACCTGGGCTA TCAGTCCCCG AGGAGCAGGT TGGCTTTTTG GAGCAAAGGT CACAAATGAG 
TTTGTTCATA TCAACAACTT AAAACTCATC TGCAGAGCAC ATCAACTAGT GCACGAAGGC 
TATAAATTTA TGTTTGATGA GAAGCTGGTG ACAGTATGGT CTGCTCCTAA TTACTGCTAT 
CGTTGTGGAA ATATTGCTTC GATCATGGTC TTCAAAGATG TAAATACAAG AGAACCAAAG 
TTATTCCGGG CAGTTCCAGA TTCAGAACGT GTTATTCCTC CCAGAACGAC AACGCCATAT 
TTCCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001116827.1
CDS	222..1250
Translation	MAPLDLDKYVEIARLCKYLPENDLKVSPICGLAPSGCGAPAGRPFLSPGPPPVFHFLRFLKERLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDSERVIPPRTTTPYFL

Target ORF information:

RefSeq Version	NM_001123355.1
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 6 catalytic subunit (PPP6C), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001123355.1

ORF Insert Sequence:

ATGGCGCCGC TAGACCTGGA CAAGTATGTG GAAATAGCGC GGCTGTGCAA GTACCTGCCA 
GAGAACGACC TGAAGGTGAG CCCTATTTGC GGGCTCGCCC CTTCCGGCTG TGGGGCGCCC 
GCCGGCCGGC CCTTCCTTTC TCCAGGACCC CCGCCGGTAT TTCATTTTCT TCGTTTTCTA 
AAGGAGCGGC TATGTGACTA CGTTTGTGAC CTCCTCTTAG AAGAGTCAAA TGTTCAGCCA 
GTATCAACAC CAGTAACAGT GTGTGGAGAT ATCCATGGAC AGTTTTATGA CCTTTGTGAA 
CTGTTCAGAA CTGGAGGTCA GGTTCCTGAC ACAAACTACA TATTTATGGG TGATTTTGTA 
GACAGAGGTT ACTATAGTTT GGAGACCTTC ACTTACCTTC TTGCATTAAA GGCTAAATGG 
CCTGATCGTA TTACACTTTT GCGAGGAAAT CATGAGAGTA GACAGATAAC ACAGGTCTAT 
GGATTTTATG ATGAGTGCCA AACCAAATAT GGAAATGCTA ATGCCTGGAG ATACTGTACC 
AAAGTTTTTG ACATGCTCAC AGTAGCAGCT TTAATAGATG AGCAGATTTT GTGTGTCCAT 
GGTGGTTTAT CTCCTGATAT CAAAACACTG GATCAAATTC GAACCATCGA ACGGAATCAG 
GAAATTCCTC ATAAAGGAGC ATTTTGTGAT CTGGTTTGGT CAGATCCTGA AGATGTGGAT 
ACCTGGGCTA TCAGTCCCCG AGGAGCAGGT TGGCTTTTTG GAGCAAAGGT CACAAATGAG 
TTTGTTCATA TCAACAACTT AAAACTCATC TGCAGAGCAC ATCAACTAGT GCACGAAGGC 
TATAAATTTA TGTTTGATGA GAAGCTGGTG ACAGTATGGT CTGCTCCTAA TTACTGCTAT 
CGTTGTGGAA ATATTGCTTC GATCATGGTC TTCAAAGATG TAAATACAAG AGAACCAAAG 
TTATTCCGGG CAGTTCCAGA TTCAGAACGT GTTATTCCTC CCAGAACGAC AACGCCATAT 
TTCCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP6C ( NM_002721.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002712.1 Homo sapiens protein phosphatase 6 catalytic subunit (PPP6C), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu27203
Clone ID Related Accession (Same CDS sequence)	NM_002721.4 , NM_002721.5
Accession Version	NM_002721.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550332800000
Organism	Homo sapiens(human)
Product	serine/threonine-protein phosphatase 6 catalytic subunit isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB037210.1, AL445930.11, BC006990.1, AA251321.1 and CB250498.1. On Apr 18, 2008 this sequence version replaced NM_002721.3. Transcript Variant: This variant (2) uses an alternate splice site and lacks an exon in the coding region, compared to variant 1; it encodes a shorter isoform (b). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence and transcripts to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.42205.1, SRR1660809.94117.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCCGC TAGACCTGGA CAAGTATGTG GAAATAGCGC GGCTGTGCAA GTACCTGCCA 
GAGAACGACC TGAAGCGGCT ATGTGACTAC GTTTGTGACC TCCTCTTAGA AGAGTCAAAT 
GTTCAGCCAG TATCAACACC AGTAACAGTG TGTGGAGATA TCCATGGACA GTTTTATGAC 
CTTTGTGAAC TGTTCAGAAC TGGAGGTCAG GTTCCTGACA CAAACTACAT ATTTATGGGT 
GATTTTGTAG ACAGAGGTTA CTATAGTTTG GAGACCTTCA CTTACCTTCT TGCATTAAAG 
GCTAAATGGC CTGATCGTAT TACACTTTTG CGAGGAAATC ATGAGAGTAG ACAGATAACA 
CAGGTCTATG GATTTTATGA TGAGTGCCAA ACCAAATATG GAAATGCTAA TGCCTGGAGA 
TACTGTACCA AAGTTTTTGA CATGCTCACA GTAGCAGCTT TAATAGATGA GCAGATTTTG 
TGTGTCCATG GTGGTTTATC TCCTGATATC AAAACACTGG ATCAAATTCG AACCATCGAA 
CGGAATCAGG AAATTCCTCA TAAAGGAGCA TTTTGTGATC TGGTTTGGTC AGATCCTGAA 
GATGTGGATA CCTGGGCTAT CAGTCCCCGA GGAGCAGGTT GGCTTTTTGG AGCAAAGGTC 
ACAAATGAGT TTGTTCATAT CAACAACTTA AAACTCATCT GCAGAGCACA TCAACTAGTG 
CACGAAGGCT ATAAATTTAT GTTTGATGAG AAGCTGGTGA CAGTATGGTC TGCTCCTAAT 
TACTGCTATC GTTGTGGAAA TATTGCTTCG ATCATGGTCT TCAAAGATGT AAATACAAGA 
GAACCAAAGT TATTCCGGGC AGTTCCAGAT TCAGAACGTG TTATTCCTCC CAGAACGACA 
ACGCCATATT TCCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002712.1
CDS	222..1139
Translation	MAPLDLDKYVEIARLCKYLPENDLKRLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDSERVIPPRTTTPYFL

Target ORF information:

RefSeq Version	NM_002721.4
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 6 catalytic subunit (PPP6C), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002721.4

ORF Insert Sequence:

ATGGCGCCGC TAGACCTGGA CAAGTATGTG GAAATAGCGC GGCTGTGCAA GTACCTGCCA 
GAGAACGACC TGAAGCGGCT ATGTGACTAC GTTTGTGACC TCCTCTTAGA AGAGTCAAAT 
GTTCAGCCAG TATCAACACC AGTAACAGTG TGTGGAGATA TCCATGGACA GTTTTATGAC 
CTTTGTGAAC TGTTCAGAAC TGGAGGTCAG GTTCCTGACA CAAACTACAT ATTTATGGGT 
GATTTTGTAG ACAGAGGTTA CTATAGTTTG GAGACCTTCA CTTACCTTCT TGCATTAAAG 
GCTAAATGGC CTGATCGTAT TACACTTTTG CGAGGAAATC ATGAGAGTAG ACAGATAACA 
CAGGTCTATG GATTTTATGA TGAGTGCCAA ACCAAATATG GAAATGCTAA TGCCTGGAGA 
TACTGTACCA AAGTTTTTGA CATGCTCACA GTAGCAGCTT TAATAGATGA GCAGATTTTG 
TGTGTCCATG GTGGTTTATC TCCTGATATC AAAACACTGG ATCAAATTCG AACCATCGAA 
CGGAATCAGG AAATTCCTCA TAAAGGAGCA TTTTGTGATC TGGTTTGGTC AGATCCTGAA 
GATGTGGATA CCTGGGCTAT CAGTCCCCGA GGAGCAGGTT GGCTTTTTGG AGCAAAGGTC 
ACAAATGAGT TTGTTCATAT CAACAACTTA AAACTCATCT GCAGAGCACA TCAACTAGTG 
CACGAAGGCT ATAAATTTAT GTTTGATGAG AAGCTGGTGA CAGTATGGTC TGCTCCTAAT 
TACTGCTATC GTTGTGGAAA TATTGCTTCG ATCATGGTCT TCAAAGATGT AAATACAAGA 
GAACCAAAGT TATTCCGGGC AGTTCCAGAT TCAGAACGTG TTATTCCTCC CAGAACGACA 
ACGCCATATT TCCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP6C ( NM_002721.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002712.1 Homo sapiens protein phosphatase 6 catalytic subunit (PPP6C), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu27203
Clone ID Related Accession (Same CDS sequence)	NM_002721.4 , NM_002721.5
Accession Version	NM_002721.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1572019200000
Organism	Homo sapiens(human)
Product	serine/threonine-protein phosphatase 6 catalytic subunit isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB037210.1, BC006990.1, AA251321.1, AL445930.11 and CB250498.1. On Jun 3, 2019 this sequence version replaced NM_002721.4. Transcript Variant: This variant (2) uses an alternate splice site and lacks an exon in the coding region, compared to variant 1; it encodes a shorter isoform (b). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence and transcripts to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.115564.1, SRR1660805.124251.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGCCGC TAGACCTGGA CAAGTATGTG GAAATAGCGC GGCTGTGCAA GTACCTGCCA 
GAGAACGACC TGAAGCGGCT ATGTGACTAC GTTTGTGACC TCCTCTTAGA AGAGTCAAAT 
GTTCAGCCAG TATCAACACC AGTAACAGTG TGTGGAGATA TCCATGGACA GTTTTATGAC 
CTTTGTGAAC TGTTCAGAAC TGGAGGTCAG GTTCCTGACA CAAACTACAT ATTTATGGGT 
GATTTTGTAG ACAGAGGTTA CTATAGTTTG GAGACCTTCA CTTACCTTCT TGCATTAAAG 
GCTAAATGGC CTGATCGTAT TACACTTTTG CGAGGAAATC ATGAGAGTAG ACAGATAACA 
CAGGTCTATG GATTTTATGA TGAGTGCCAA ACCAAATATG GAAATGCTAA TGCCTGGAGA 
TACTGTACCA AAGTTTTTGA CATGCTCACA GTAGCAGCTT TAATAGATGA GCAGATTTTG 
TGTGTCCATG GTGGTTTATC TCCTGATATC AAAACACTGG ATCAAATTCG AACCATCGAA 
CGGAATCAGG AAATTCCTCA TAAAGGAGCA TTTTGTGATC TGGTTTGGTC AGATCCTGAA 
GATGTGGATA CCTGGGCTAT CAGTCCCCGA GGAGCAGGTT GGCTTTTTGG AGCAAAGGTC 
ACAAATGAGT TTGTTCATAT CAACAACTTA AAACTCATCT GCAGAGCACA TCAACTAGTG 
CACGAAGGCT ATAAATTTAT GTTTGATGAG AAGCTGGTGA CAGTATGGTC TGCTCCTAAT 
TACTGCTATC GTTGTGGAAA TATTGCTTCG ATCATGGTCT TCAAAGATGT AAATACAAGA 
GAACCAAAGT TATTCCGGGC AGTTCCAGAT TCAGAACGTG TTATTCCTCC CAGAACGACA 
ACGCCATATT TCCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002712.1
CDS	86..1003
Translation	MAPLDLDKYVEIARLCKYLPENDLKRLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDSERVIPPRTTTPYFL

Target ORF information:

RefSeq Version	NM_002721.5
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 6 catalytic subunit (PPP6C), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002721.5

ORF Insert Sequence:

ATGGCGCCGC TAGACCTGGA CAAGTATGTG GAAATAGCGC GGCTGTGCAA GTACCTGCCA 
GAGAACGACC TGAAGCGGCT ATGTGACTAC GTTTGTGACC TCCTCTTAGA AGAGTCAAAT 
GTTCAGCCAG TATCAACACC AGTAACAGTG TGTGGAGATA TCCATGGACA GTTTTATGAC 
CTTTGTGAAC TGTTCAGAAC TGGAGGTCAG GTTCCTGACA CAAACTACAT ATTTATGGGT 
GATTTTGTAG ACAGAGGTTA CTATAGTTTG GAGACCTTCA CTTACCTTCT TGCATTAAAG 
GCTAAATGGC CTGATCGTAT TACACTTTTG CGAGGAAATC ATGAGAGTAG ACAGATAACA 
CAGGTCTATG GATTTTATGA TGAGTGCCAA ACCAAATATG GAAATGCTAA TGCCTGGAGA 
TACTGTACCA AAGTTTTTGA CATGCTCACA GTAGCAGCTT TAATAGATGA GCAGATTTTG 
TGTGTCCATG GTGGTTTATC TCCTGATATC AAAACACTGG ATCAAATTCG AACCATCGAA 
CGGAATCAGG AAATTCCTCA TAAAGGAGCA TTTTGTGATC TGGTTTGGTC AGATCCTGAA 
GATGTGGATA CCTGGGCTAT CAGTCCCCGA GGAGCAGGTT GGCTTTTTGG AGCAAAGGTC 
ACAAATGAGT TTGTTCATAT CAACAACTTA AAACTCATCT GCAGAGCACA TCAACTAGTG 
CACGAAGGCT ATAAATTTAT GTTTGATGAG AAGCTGGTGA CAGTATGGTC TGCTCCTAAT 
TACTGCTATC GTTGTGGAAA TATTGCTTCG ATCATGGTCT TCAAAGATGT AAATACAAGA 
GAACCAAAGT TATTCCGGGC AGTTCCAGAT TCAGAACGTG TTATTCCTCC CAGAACGACA 
ACGCCATATT TCCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Global assessment of its network dynamics reveals that the kinase Plk1 inhibits the phosphatase PP6 to promote Aurora A activity.
Science signaling11(530)(2018 05)
Kettenbach AN,Schlosser KA,Lyons SP,Nasa I,Gui J,Adamo ME,Gerber SA

A PP6-ASK3 Module Coordinates the Bidirectional Cell Volume Regulation under Osmotic Stress.
Cell reports22(11)2809-2817(2018 03)
Watanabe K,Umeda T,Niwa K,Naguro I,Ichijo H

Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling.
Molecular cell68(2)293-307.e5(2017 Oct)
Tan P,He L,Cui J,Qian C,Cao X,Lin M,Zhu Q,Li Y,Xing C,Yu X,Wang HY,Wang RF

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
Cell systems4(4)430-444.e5(2017 04)
Yadav L,Tamene F,Göös H,van Drogen A,Katainen R,Aebersold R,Gstaiger M,Varjosalo M

The three Type 2A protein phosphatases, PP2Ac, PP4c and PP6c, are differentially regulated by Alpha4.
Biochemical and biophysical research communications475(1)64-9(2016 06)
LeNoue-Newton ML,Wadzinski BE,Spiller BW

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PPP6C cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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