| Gene Symbol | PENK |
| Entrez Gene ID | 5179 |
| Full Name | proenkephalin |
| Synonyms | PE,PENK-A |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015]. |
| Disorder MIM: |
- REAGENT SERVICES Hot!
-
PRODUCTS
-
Most Popular Reagents
-
Instruments
-
Antibodies
-
ELISA Kits
-
Protein Electrophoresis and Blotting
-
Protein and Antibody Purification
-
Recombinant Proteins
-
Molecular Biology
-
Stable Cell Lines
-
Cell Isolation and Activation
-
IVD Raw Materials
-
Therapy Applications
-
Resources
-
![AmMag™ Quatro Automated Plasmid Purification]()
AmMag™ Quatro automated plasmid purification
-
![Anti-Camelid VHH]()
MonoRab™ Anti-VHH Antibodies
-
![ELISA Kits]()
ELISA Kits
-
![Precast Gels]()
SurePAGE™ Precast Gels
-
![Quatro ProAb Automated Protein and Antibody Purification System]()
AmMag™ Quatro ProAb Automated Protein and Antibody Purification System
-
![Target Proteins]()
Target Proteins
-
![AmMag™ Quatro Automated Plasmid Purification]()
AmMag™ Quatro automated plasmid purification
-
![Stable Cell Lines]()
Stable Cell Lines
-
![Cell Isolation and Activation]()
Cell Isolation and Activation
-
![Quick
Order]()
Quick Order
-
![Quick
Order]()
Quick Order
- APPLICATIONS
- RESOURCES
- ABOUT US
PENK cDNA ORF clone, Homo sapiens(human)
-
Gene
-
Clones
gRNAs
The following PENK gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PENK cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
Online Only Promotion
Up to 50% OFF! Starting
from $49/clone
-
Reference Sequences (Refseq)
CloneID OHu23531 Clone ID Related Accession (Same CDS sequence) NM_001135690.3 , NM_001135690.2 Accession Version NM_001135690.3 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 804bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1565107200000 Organism Homo sapiens(human) Product proenkephalin-A preproprotein Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK314908.1 and BI496610.1. On Nov 24, 2018 this sequence version replaced NM_001135690.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189667.173079.1, SRR1660805.88477.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000451791.7/ ENSP00000400894.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541
601
661
721
781ATGGCGCGGT TCCTGACACT TTGCACTTGG CTGCTGTTGC TCGGCCCCGG GCTCCTGGCG
ACCGTGCGGG CCGAATGCAG CCAGGATTGC GCGACGTGCA GCTACCGCCT AGTGCGCCCG
GCCGACATCA ACTTCCTGGC TTGCGTAATG GAATGTGAAG GTAAACTGCC TTCTCTGAAA
ATTTGGGAAA CCTGCAAGGA GCTCCTGCAG CTGTCCAAAC CAGAGCTTCC TCAAGATGGC
ACCAGCACCC TCAGAGAAAA TAGCAAACCG GAAGAAAGCC ATTTGCTAGC CAAAAGGTAT
GGGGGCTTCA TGAAAAGGTA TGGAGGCTTC ATGAAGAAAA TGGATGAGCT TTATCCCATG
GAGCCAGAAG AAGAGGCCAA TGGAAGTGAG ATCCTCGCCA AGCGGTATGG GGGCTTCATG
AAGAAGGATG CAGAGGAGGA CGACTCGCTG GCCAATTCCT CAGACCTGCT AAAAGAGCTT
CTGGAAACAG GGGACAACCG AGAGCGTAGC CACCACCAGG ATGGCAGTGA TAATGAGGAA
GAAGTGAGCA AGAGATATGG GGGCTTCATG AGAGGCTTAA AGAGAAGCCC CCAACTGGAA
GATGAAGCCA AAGAGCTGCA GAAGCGATAT GGGGGCTTCA TGAGAAGAGT AGGTCGCCCA
GAGTGGTGGA TGGACTACCA GAAACGGTAT GGAGGTTTCC TGAAGCGCTT TGCCGAGGCT
CTGCCCTCCG ACGAAGAAGG CGAAAGTTAC TCCAAAGAAG TTCCTGAAAT GGAAAAAAGA
TACGGAGGAT TTATGAGATT TTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001129162.1 CDS 133..936 Translation 
Target ORF information:
RefSeq Version NM_001135690.3 Organism Homo sapiens(human) Definition Homo sapiens proenkephalin (PENK), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_001135690.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781ATGGCGCGGT TCCTGACACT TTGCACTTGG CTGCTGTTGC TCGGCCCCGG GCTCCTGGCG
ACCGTGCGGG CCGAATGCAG CCAGGATTGC GCGACGTGCA GCTACCGCCT AGTGCGCCCG
GCCGACATCA ACTTCCTGGC TTGCGTAATG GAATGTGAAG GTAAACTGCC TTCTCTGAAA
ATTTGGGAAA CCTGCAAGGA GCTCCTGCAG CTGTCCAAAC CAGAGCTTCC TCAAGATGGC
ACCAGCACCC TCAGAGAAAA TAGCAAACCG GAAGAAAGCC ATTTGCTAGC CAAAAGGTAT
GGGGGCTTCA TGAAAAGGTA TGGAGGCTTC ATGAAGAAAA TGGATGAGCT TTATCCCATG
GAGCCAGAAG AAGAGGCCAA TGGAAGTGAG ATCCTCGCCA AGCGGTATGG GGGCTTCATG
AAGAAGGATG CAGAGGAGGA CGACTCGCTG GCCAATTCCT CAGACCTGCT AAAAGAGCTT
CTGGAAACAG GGGACAACCG AGAGCGTAGC CACCACCAGG ATGGCAGTGA TAATGAGGAA
GAAGTGAGCA AGAGATATGG GGGCTTCATG AGAGGCTTAA AGAGAAGCCC CCAACTGGAA
GATGAAGCCA AAGAGCTGCA GAAGCGATAT GGGGGCTTCA TGAGAAGAGT AGGTCGCCCA
GAGTGGTGGA TGGACTACCA GAAACGGTAT GGAGGTTTCC TGAAGCGCTT TGCCGAGGCT
CTGCCCTCCG ACGAAGAAGG CGAAAGTTAC TCCAAAGAAG TTCCTGAAAT GGAAAAAAGA
TACGGAGGAT TTATGAGATT TTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu23531 Clone ID Related Accession (Same CDS sequence) NM_001135690.3 , NM_001135690.2 Accession Version NM_001135690.2 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 804bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1514649600000 Organism Homo sapiens(human) Product proenkephalin-A preproprotein Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP370091.1, DB496514.1, AK314908.1 and BI496610.1. On Jul 21, 2015 this sequence version replaced NM_001135690.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.88477.1, ERR279837.3641.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661
721
781ATGGCGCGGT TCCTGACACT TTGCACTTGG CTGCTGTTGC TCGGCCCCGG GCTCCTGGCG
ACCGTGCGGG CCGAATGCAG CCAGGATTGC GCGACGTGCA GCTACCGCCT AGTGCGCCCG
GCCGACATCA ACTTCCTGGC TTGCGTAATG GAATGTGAAG GTAAACTGCC TTCTCTGAAA
ATTTGGGAAA CCTGCAAGGA GCTCCTGCAG CTGTCCAAAC CAGAGCTTCC TCAAGATGGC
ACCAGCACCC TCAGAGAAAA TAGCAAACCG GAAGAAAGCC ATTTGCTAGC CAAAAGGTAT
GGGGGCTTCA TGAAAAGGTA TGGAGGCTTC ATGAAGAAAA TGGATGAGCT TTATCCCATG
GAGCCAGAAG AAGAGGCCAA TGGAAGTGAG ATCCTCGCCA AGCGGTATGG GGGCTTCATG
AAGAAGGATG CAGAGGAGGA CGACTCGCTG GCCAATTCCT CAGACCTGCT AAAAGAGCTT
CTGGAAACAG GGGACAACCG AGAGCGTAGC CACCACCAGG ATGGCAGTGA TAATGAGGAA
GAAGTGAGCA AGAGATATGG GGGCTTCATG AGAGGCTTAA AGAGAAGCCC CCAACTGGAA
GATGAAGCCA AAGAGCTGCA GAAGCGATAT GGGGGCTTCA TGAGAAGAGT AGGTCGCCCA
GAGTGGTGGA TGGACTACCA GAAACGGTAT GGAGGTTTCC TGAAGCGCTT TGCCGAGGCT
CTGCCCTCCG ACGAAGAAGG CGAAAGTTAC TCCAAAGAAG TTCCTGAAAT GGAAAAAAGA
TACGGAGGAT TTATGAGATT TTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001129162.1 CDS 226..1029 Translation
Target ORF information:
RefSeq Version NM_001135690.2 Organism Homo sapiens(human) Definition Homo sapiens proenkephalin (PENK), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_001135690.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781ATGGCGCGGT TCCTGACACT TTGCACTTGG CTGCTGTTGC TCGGCCCCGG GCTCCTGGCG
ACCGTGCGGG CCGAATGCAG CCAGGATTGC GCGACGTGCA GCTACCGCCT AGTGCGCCCG
GCCGACATCA ACTTCCTGGC TTGCGTAATG GAATGTGAAG GTAAACTGCC TTCTCTGAAA
ATTTGGGAAA CCTGCAAGGA GCTCCTGCAG CTGTCCAAAC CAGAGCTTCC TCAAGATGGC
ACCAGCACCC TCAGAGAAAA TAGCAAACCG GAAGAAAGCC ATTTGCTAGC CAAAAGGTAT
GGGGGCTTCA TGAAAAGGTA TGGAGGCTTC ATGAAGAAAA TGGATGAGCT TTATCCCATG
GAGCCAGAAG AAGAGGCCAA TGGAAGTGAG ATCCTCGCCA AGCGGTATGG GGGCTTCATG
AAGAAGGATG CAGAGGAGGA CGACTCGCTG GCCAATTCCT CAGACCTGCT AAAAGAGCTT
CTGGAAACAG GGGACAACCG AGAGCGTAGC CACCACCAGG ATGGCAGTGA TAATGAGGAA
GAAGTGAGCA AGAGATATGG GGGCTTCATG AGAGGCTTAA AGAGAAGCCC CCAACTGGAA
GATGAAGCCA AAGAGCTGCA GAAGCGATAT GGGGGCTTCA TGAGAAGAGT AGGTCGCCCA
GAGTGGTGGA TGGACTACCA GAAACGGTAT GGAGGTTTCC TGAAGCGCTT TGCCGAGGCT
CTGCCCTCCG ACGAAGAAGG CGAAAGTTAC TCCAAAGAAG TTCCTGAAAT GGAAAAAAGA
TACGGAGGAT TTATGAGATT TTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
-
PubMed
Proenkephalin and risk of developing chronic kidney disease: the Prevention of Renal and Vascular End-stage Disease study.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals23(5)474-482(2018 Jul)
Kieneker LM,Hartmann O,Bergmann A,de Boer RA,Gansevoort RT,Joosten MM,Struck J,Bakker SJL
Proinflammatory Markers, Chemokines, and Enkephalin in Patients Suffering from Dry Eye Disease.
International journal of molecular sciences19(4)(2018 Apr)
Nicolle P,Liang H,Reboussin E,Rabut G,Warcoin E,Brignole-Baudouin F,Melik-Parsadaniantz S,Baudouin C,Labbe A,Reaux-Le Goazigo A
Elevation of Proenkephalin 143-183 in Cerebrospinal Fluid in Moyamoya Disease.
World neurosurgery109e446-e459(2018 Jan)
Yokoyama K,Maruwaka M,Yoshikawa K,Araki Y,Okamoto S,Sumitomo M,Kawamura A,Sakamoto Y,Shimizu K,Izumi T,Wakabayashi T
The effects of different exercise training modalities on plasma proenkephalin Peptide F in women.
Peptides9126-32(2017 05)
DuPont WH,Kraemer WJ,Nindl BC,Lee EC,Fragala MS,Hatfield DL,Caldwell LK,Post EM,Beeler MK,Volek JS,Maresh CM
Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7.
Nature communications68967(2015 Dec)
Minett MS,Pereira V,Sikandar S,Matsuyama A,Lolignier S,Kanellopoulos AH,Mancini F,Iannetti GD,Bogdanov YD,Santana-Varela S,Millet Q,Baskozos G,MacAllister R,Cox JJ,Zhao J,Wood JN
-
-
Most Popular Services
-
Services & Products
-
News & Blogs
- Cancer Cells Use Regulatory T Cells to Activate Antitumor Immunosuppression
- Cannabinoid agonist induces weight loss without adverse central nervous system effects
- New Technology Paired with NGS, Paves the Way for Novel Therapeutic Antibodies
- DNA Will Be the Building Block of the Future
- Structural Properties of Pangolin-CoV Spike Glycoprotein Reveal Evolutionary Insight of SARS-CoV-2
- Infection and Vaccine-Induced T cell Responses Confer SARS-CoV-2 Variant Protection
- New High-throughput Platform to Expedite Shared Neoantigen-Based Cancer Immunotherapies
- Scientists Successfully Created Three-eyed, Wingless Mosquitoes in Real Life
-
-
-
PubMed
-
