| Gene Symbol | SF3B6 |
| Entrez Gene ID | 51639 |
| Full Name | splicing factor 3b subunit 6 |
| Synonyms | CGI-110,HSPC175,Ht006,P14,SAP14,SAP14a,SF3B14,SF3B14a |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
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SF3B6 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following SF3B6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SF3B6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu25649 Clone ID Related Accession (Same CDS sequence) NM_016047.4 , NM_016047.3 Accession Version NM_016047.4 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 378bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1559836800000 Organism Homo sapiens(human) Product splicing factor 3B subunit 6 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC015463.1 and BG200650.1. On Nov 22, 2018 this sequence version replaced NM_016047.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.172119.1, SRR1163657.34312.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000233468.5/ ENSP00000233468.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361ATGGCGATGC AAGCGGCCAA GAGGGCGAAC ATTCGACTTC CACCTGAAGT AAATCGGATA
TTGTATATAA GAAATTTGCC ATACAAAATC ACAGCTGAAG AAATGTATGA TATATTTGGG
AAATATGGAC CTATTCGTCA AATCAGAGTG GGGAACACAC CTGAAACTAG AGGAACAGCT
TATGTGGTCT ATGAGGACAT CTTTGATGCC AAGAATGCAT GTGATCACCT ATCGGGATTC
AATGTTTGTA ACAGATACCT TGTGGTTTTG TACTATAATG CCAACAGGGC ATTTCAGAAG
ATGGACACAA AGAAGAAGGA GGAACAGTTG AAGCTTCTCA AGGAGAAATA TGGCATCAAC
ACAGATCCAC CAAAATAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_057131.1 CDS 98..475 Translation 
Target ORF information:
RefSeq Version NM_016047.4 Organism Homo sapiens(human) Definition Homo sapiens splicing factor 3b subunit 6 (SF3B6), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_016047.4
ORF Insert Sequence:
1
61
121
181
241
301
361ATGGCGATGC AAGCGGCCAA GAGGGCGAAC ATTCGACTTC CACCTGAAGT AAATCGGATA
TTGTATATAA GAAATTTGCC ATACAAAATC ACAGCTGAAG AAATGTATGA TATATTTGGG
AAATATGGAC CTATTCGTCA AATCAGAGTG GGGAACACAC CTGAAACTAG AGGAACAGCT
TATGTGGTCT ATGAGGACAT CTTTGATGCC AAGAATGCAT GTGATCACCT ATCGGGATTC
AATGTTTGTA ACAGATACCT TGTGGTTTTG TACTATAATG CCAACAGGGC ATTTCAGAAG
ATGGACACAA AGAAGAAGGA GGAACAGTTG AAGCTTCTCA AGGAGAAATA TGGCATCAAC
ACAGATCCAC CAAAATAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu25649 Clone ID Related Accession (Same CDS sequence) NM_016047.4 , NM_016047.3 Accession Version NM_016047.3 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 378bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1506700800000 Organism Homo sapiens(human) Product splicing factor 3B subunit 6 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC015463.1 and BG200650.1. On Oct 23, 2004 this sequence version replaced NM_016047.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC015463.1, SRR1163658.323032.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361ATGGCGATGC AAGCGGCCAA GAGGGCGAAC ATTCGACTTC CACCTGAAGT AAATCGGATA
TTGTATATAA GAAATTTGCC ATACAAAATC ACAGCTGAAG AAATGTATGA TATATTTGGG
AAATATGGAC CTATTCGTCA AATCAGAGTG GGGAACACAC CTGAAACTAG AGGAACAGCT
TATGTGGTCT ATGAGGACAT CTTTGATGCC AAGAATGCAT GTGATCACCT ATCGGGATTC
AATGTTTGTA ACAGATACCT TGTGGTTTTG TACTATAATG CCAACAGGGC ATTTCAGAAG
ATGGACACAA AGAAGAAGGA GGAACAGTTG AAGCTTCTCA AGGAGAAATA TGGCATCAAC
ACAGATCCAC CAAAATAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_057131.1 CDS 216..593 Translation
Target ORF information:
RefSeq Version NM_016047.3 Organism Homo sapiens(human) Definition Homo sapiens splicing factor 3b subunit 6 (SF3B6), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_016047.3
ORF Insert Sequence:
1
61
121
181
241
301
361ATGGCGATGC AAGCGGCCAA GAGGGCGAAC ATTCGACTTC CACCTGAAGT AAATCGGATA
TTGTATATAA GAAATTTGCC ATACAAAATC ACAGCTGAAG AAATGTATGA TATATTTGGG
AAATATGGAC CTATTCGTCA AATCAGAGTG GGGAACACAC CTGAAACTAG AGGAACAGCT
TATGTGGTCT ATGAGGACAT CTTTGATGCC AAGAATGCAT GTGATCACCT ATCGGGATTC
AATGTTTGTA ACAGATACCT TGTGGTTTTG TACTATAATG CCAACAGGGC ATTTCAGAAG
ATGGACACAA AGAAGAAGGA GGAACAGTTG AAGCTTCTCA AGGAGAAATA TGGCATCAAC
ACAGATCCAC CAAAATAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.
Nature communications815522(2017 05)
Teng T,Tsai JH,Puyang X,Seiler M,Peng S,Prajapati S,Aird D,Buonamici S,Caleb B,Chan B,Corson L,Feala J,Fekkes P,Gerard B,Karr C,Korpal M,Liu X,T Lowe J,Mizui Y,Palacino J,Park E,Smith PG,Subramanian V,Wu ZJ,Zou J,Yu L,Chicas A,Warmuth M,Larsen N,Zhu P
Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations.
Molecular cell64(2)307-319(2016 10)
Cretu C,Schmitzová J,Ponce-Salvatierra A,Dybkov O,De Laurentiis EI,Sharma K,Will CL,Urlaub H,Lührmann R,Pena V
Interaction between the Spliceosomal Pre-mRNA Branch Site and U2 snRNP Protein p14.
Biochemistry55(4)629-32(2016 Feb)
Perea W,Schroeder KT,Bryant AN,Greenbaum NL
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanhäusser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M
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