OTUD6B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OTUD6B
Entrez Gene ID	51633
Full Name	OTU domain containing 6B
Synonyms	CGI-77,DUBA-5,DUBA5,IDDFSDA
General protein information	Preferred Names OTU domain containing 6B Names OTU domain-containing protein 6B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q21.3
Summary	This gene encodes a member of the ovarian tumor domain (OTU)-containing subfamily of deubiquitinating enzymes. Deubiquitinating enzymes are primarily involved in removing ubiquitin from proteins targeted for degradation. This protein may function as a negative regulator of the cell cycle in B cells. [provided by RefSeq, Nov 2013].
Disorder MIM:	612021
Disorder Html:	Intellectual developmental disorder with dysmorphic facies, seizures, and distal limb anomalies, 617452 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_016023.3	NP_057107.3	OTU domain-containing protein 6B isoform 1
NM_016023.4	NP_057107.4	deubiquitinase OTUD6B isoform 1
XM_011517129.2	XP_011515431.2	deubiquitinase OTUD6B isoform X1
NM_001286745.2	NP_001273674.1	deubiquitinase OTUD6B isoform 2
NM_016023.5	NP_057107.4	deubiquitinase OTUD6B isoform 1
NM_001286745.1	NP_001273674.1	OTU domain-containing protein 6B isoform 2

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	OTUD6B	XP_001086186.2
Mus musculus (house mouse)	Otud6b	NP_690025.2
Arabidopsis thaliana (thale cress)	AT3G62940	NP_850739.1
Danio rerio (zebrafish)	otud6b	NP_956519.1
Xenopus tropicalis (tropical clawed frog)	otud6b	NP_001011269.1
Pan troglodytes (chimpanzee)	OTUD6B	XP_003311873.1
Rattus norvegicus (Norway rat)	Otud6b	NP_001100109.1
Bos taurus (cattle)	OTUD6B	XP_005228655.1
Homo sapiens (human)	OTUD6B	NP_057107.3
Drosophila melanogaster (fruit fly)	CG7857	NP_648769.2
Caenorhabditis elegans (roundworm)	F21D5.2	NP_001255318.1
Oryza sativa (rice)	Os04g0619500	NP_001053899.1
Canis lupus familiaris (dog)	OTUD6B	XP_544171.2
Gallus gallus (chicken)	OTUD6B	NP_001006347.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006160	XP_316218.4

Gene Ontology
Bibliography

Related articles in PubMed

Biallelic Variants in OTUD6B Cause an Intellectual Disability Syndrome Associated with Seizures and Dysmorphic Features.
Santiago-Sim T, Burrage LC, Ebstein F, Tokita MJ, Miller M, Bi W, Braxton AA, Rosenfeld JA, Shahrour M, Lehmann A, Cogné B, Küry S, Besnard T, Isidor B, Bézieau S, Hazart I, Nagakura H, Immken LL, Littlejohn RO, Roeder E, , Kara B, Hardies K, Weckhuysen S, May P, Lemke JR, Elpeleg O, Abu-Libdeh B, James KN, Silhavy JL, Issa MY, Zaki MS, Gleeson JG, Seavitt JR, Dickinson ME, Ljungberg MC, Wells S, Johnson SJ, Teboul L, Eng CM, Yang Y, Kloetzel PM, Heaney JD, Walkiewicz MA
American journal of human genetics100(4)676-688(2017 Apr)

Deubiquitinase OTUD6B Isoforms Are Important Regulators of Growth and Proliferation.
Sobol A, Askonas C, Alani S, Weber MJ, Ananthanarayanan V, Osipo C, Bocchetta M
Molecular cancer research : MCR15(2)117-127(2017 02)

Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation.
Xu Z, Zheng Y, Zhu Y, Kong X, Hu L
PloS one6(1)e14514(2011 Jan)

Defining the human deubiquitinating enzyme interaction landscape.
Sowa ME, Bennett EJ, Gygi SP, Harper JW
Cell138(2)389-403(2009 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following OTUD6B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OTUD6B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02268	NM_016023.3 Latest version!	Homo sapiens OTU domain containing 6B (OTUD6B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu07802	NM_001286745.2 Latest version!	Homo sapiens OTU deubiquitinase 6B (OTUD6B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu107066	NM_016023.5 Latest version!	Homo sapiens OTU deubiquitinase 6B (OTUD6B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu07802	XM_011517129.2 Latest version!	Homo sapiens OTU deubiquitinase 6B (OTUD6B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu107066	NM_016023.4	Homo sapiens OTU domain containing 6B (OTUD6B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu07802	NM_001286745.1	Homo sapiens OTU domain containing 6B (OTUD6B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OTUD6B ( NM_016023.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057107.3 Homo sapiens OTU domain containing 6B (OTUD6B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02268
Clone ID Related Accession (Same CDS sequence)	NM_016023.3
Accession Version	NM_016023.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1508601600000
Organism	Homo sapiens(human)
Product	OTU domain-containing protein 6B isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC087439.6, DA034027.1, BC029760.1, BI712470.1 and AA748163.1. On Sep 19, 2007 this sequence version replaced NM_016023.2. Transcript Variant: This variant (1) encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1660809.73950.1, BX647772.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCCC GGGTGAGGGT TGAGGGGTGG AAGGTGCCTA CTAGCCGGTG CAGGTTTCTT 
CTAGCGCGTG TGCTGGGGTA CCTGGTCGTC ATGGAGGCGG TATTGACCGA AGAGCTTGAT 
GAGGAAGAGC AGCTGCTGAG AAGGCATCGC AAAGAGAAGA AGGAGTTGCA AGCCAAAATT 
CAGGGCATGA AGAATGCTGT TCCCAAGAAT GACAAGAAGA GGAGGAAGCA ACTCACCGAA 
GATGTGGCCA AGTTGGAAAA AGAAATGGAA CAGAAACATA GAGAGGAACT GGAGCAATTG 
AAGCTGACTA CTAAGGAGAA TAAGATAGAT TCTGTTGCTG TTAACATTTC AAACTTGGTG 
CTTGAGAATC AGCCACCTCG GATATCAAAA GCACAAAAGA GACGGGAAAA GAAAGCTGCA 
TTGGAAAAGG AGCGAGAAGA ACGGATAGCT GAAGCTGAAA TTGAAAACTT AACAGGAGCC 
AGACATATGG AAAGTGAGAA ACTTGCTCAA ATATTGGCAG CTAGACAGTT AGAAATTAAA 
CAGATTCCAT CTGATGGCCA CTGTATGTAT AAAGCCATTG AAGATCAACT GAAAGAAAAG 
GATTGTGCTC TGACTGTGGT TGCCTTGAGA AGTCAGACCG CTGAGTATAT GCAAAGCCAT 
GTGGAAGACT TTCTGCCATT TTTAACAAAC CCTAATACAG GAGATATGTA TACTCCAGAA 
GAATTTCAGA AGTACTGTGA AGATATTGTA AACACAGCTG CATGGGGAGG TCAGCTTGAG 
CTAAGAGCTC TGTCTCACAT TTTACAAACA CCAATAGAGA TAATACAGGC AGATTCTCCT 
CCCATTATAG TTGGTGAAGA ATATTCAAAA AAACCACTAA TACTTGTATA TATGAGACAT 
GCATATGGCT TAGGAGAACA TTATAATTCG GTTACACGGT TGGTAAACAT AGTTACTGAA 
AATTGCAGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057107.3
CDS	100..1071
Translation	MEPRVRVEGWKVPTSRCRFLLARVLGYLVVMEAVLTEELDEEEQLLRRHRKEKKELQAKIQGMKNAVPKNDKKRRKQLTEDVAKLEKEMEQKHREELEQLKLTTKENKIDSVAVNISNLVLENQPPRISKAQKRREKKAALEKEREERIAEAEIENLTGARHMESEKLAQILAARQLEIKQIPSDGHCMYKAIEDQLKEKDCALTVVALRSQTAEYMQSHVEDFLPFLTNPNTGDMYTPEEFQKYCEDIVNTAAWGGQLELRALSHILQTPIEIIQADSPPIIVGEEYSKKPLILVYMRHAYGLGEHYNSVTRLVNIVTENCS

Target ORF information:

RefSeq Version	NM_016023.3
Organism	Homo sapiens(human)
Definition	Homo sapiens OTU domain containing 6B (OTUD6B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016023.3

ORF Insert Sequence:

ATGGAGCCCC GGGTGAGGGT TGAGGGGTGG AAGGTGCCTA CTAGCCGGTG CAGGTTTCTT 
CTAGCGCGTG TGCTGGGGTA CCTGGTCGTC ATGGAGGCGG TATTGACCGA AGAGCTTGAT 
GAGGAAGAGC AGCTGCTGAG AAGGCATCGC AAAGAGAAGA AGGAGTTGCA AGCCAAAATT 
CAGGGCATGA AGAATGCTGT TCCCAAGAAT GACAAGAAGA GGAGGAAGCA ACTCACCGAA 
GATGTGGCCA AGTTGGAAAA AGAAATGGAA CAGAAACATA GAGAGGAACT GGAGCAATTG 
AAGCTGACTA CTAAGGAGAA TAAGATAGAT TCTGTTGCTG TTAACATTTC AAACTTGGTG 
CTTGAGAATC AGCCACCTCG GATATCAAAA GCACAAAAGA GACGGGAAAA GAAAGCTGCA 
TTGGAAAAGG AGCGAGAAGA ACGGATAGCT GAAGCTGAAA TTGAAAACTT AACAGGAGCC 
AGACATATGG AAAGTGAGAA ACTTGCTCAA ATATTGGCAG CTAGACAGTT AGAAATTAAA 
CAGATTCCAT CTGATGGCCA CTGTATGTAT AAAGCCATTG AAGATCAACT GAAAGAAAAG 
GATTGTGCTC TGACTGTGGT TGCCTTGAGA AGTCAGACCG CTGAGTATAT GCAAAGCCAT 
GTGGAAGACT TTCTGCCATT TTTAACAAAC CCTAATACAG GAGATATGTA TACTCCAGAA 
GAATTTCAGA AGTACTGTGA AGATATTGTA AACACAGCTG CATGGGGAGG TCAGCTTGAG 
CTAAGAGCTC TGTCTCACAT TTTACAAACA CCAATAGAGA TAATACAGGC AGATTCTCCT 
CCCATTATAG TTGGTGAAGA ATATTCAAAA AAACCACTAA TACTTGTATA TATGAGACAT 
GCATATGGCT TAGGAGAACA TTATAATTCG GTTACACGGT TGGTAAACAT AGTTACTGAA 
AATTGCAGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OTUD6B ( NM_001286745.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001273674.1 Homo sapiens OTU deubiquitinase 6B (OTUD6B), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07802
Clone ID Related Accession (Same CDS sequence)	XM_011517129.2 , NM_001286745.2 , NM_001286745.1
Accession Version	NM_001286745.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1564588800000
Organism	Homo sapiens(human)
Product	deubiquitinase OTUD6B isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC087439.6, AK293843.1 and BQ000463.1. On Jul 12, 2018 this sequence version replaced NM_001286745.1. Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.54780.1, SRR1660807.29894.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END##

ATGATATCTA AGGAAAAGAA AGCTGCATTG GAAAAGGAGC GAGAAGAACG GATAGCTGAA 
GCTGAAATTG AAAACTTAAC AGGAGCCAGA CATATGGAAA GTGAGAAACT TGCTCAAATA 
TTGGCAGCTA GACAGTTAGA AATTAAACAG ATTCCATCTG ATGGCCACTG TATGTATAAA 
GCCATTGAAG ATCAACTGAA AGAAAAGGAT TGTGCTCTGA CTGTGGTTGC CTTGAGAAGT 
CAGACCGCTG AGTATATGCA AAGCCATGTG GAAGACTTTC TGCCATTTTT AACAAACCCT 
AATACAGGAG ATATGTATAC TCCAGAAGAA TTTCAGAAGT ACTGTGAAGA TATTGTAAAC 
ACAGCTGCAT GGGGAGGTCA GCTTGAGCTA AGAGCTCTGT CTCACATTTT ACAAACACCA 
ATAGAGATAA TACAGGCAGA TTCTCCTCCC ATTATAGTTG GTGAAGAATA TTCAAAAAAA 
CCACTAATAC TTGTATATAT GAGACATGCA TATGGCTTAG GAGAACATTA TAATTCGGTT 
ACACGGTTGG TAAACATAGT TACTGAAAAT TGCAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001273674.1
CDS	485..1063
Translation	MISKEKKAALEKEREERIAEAEIENLTGARHMESEKLAQILAARQLEIKQIPSDGHCMYKAIEDQLKEKDCALTVVALRSQTAEYMQSHVEDFLPFLTNPNTGDMYTPEEFQKYCEDIVNTAAWGGQLELRALSHILQTPIEIIQADSPPIIVGEEYSKKPLILVYMRHAYGLGEHYNSVTRLVNIVTENCS

Target ORF information:

RefSeq Version	NM_001286745.2
Organism	Homo sapiens(human)
Definition	Homo sapiens OTU deubiquitinase 6B (OTUD6B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001286745.2

ORF Insert Sequence:

ATGATATCTA AGGAAAAGAA AGCTGCATTG GAAAAGGAGC GAGAAGAACG GATAGCTGAA 
GCTGAAATTG AAAACTTAAC AGGAGCCAGA CATATGGAAA GTGAGAAACT TGCTCAAATA 
TTGGCAGCTA GACAGTTAGA AATTAAACAG ATTCCATCTG ATGGCCACTG TATGTATAAA 
GCCATTGAAG ATCAACTGAA AGAAAAGGAT TGTGCTCTGA CTGTGGTTGC CTTGAGAAGT 
CAGACCGCTG AGTATATGCA AAGCCATGTG GAAGACTTTC TGCCATTTTT AACAAACCCT 
AATACAGGAG ATATGTATAC TCCAGAAGAA TTTCAGAAGT ACTGTGAAGA TATTGTAAAC 
ACAGCTGCAT GGGGAGGTCA GCTTGAGCTA AGAGCTCTGT CTCACATTTT ACAAACACCA 
ATAGAGATAA TACAGGCAGA TTCTCCTCCC ATTATAGTTG GTGAAGAATA TTCAAAAAAA 
CCACTAATAC TTGTATATAT GAGACATGCA TATGGCTTAG GAGAACATTA TAATTCGGTT 
ACACGGTTGG TAAACATAGT TACTGAAAAT TGCAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OTUD6B ( NM_001286745.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001273674.1 Homo sapiens OTU domain containing 6B (OTUD6B), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07802
Clone ID Related Accession (Same CDS sequence)	XM_011517129.2 , NM_001286745.2 , NM_001286745.1
Accession Version	NM_001286745.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1508688000000
Organism	Homo sapiens(human)
Product	OTU domain-containing protein 6B isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC087439.6, AK293843.1 and BQ000463.1. On Nov 15, 2013 this sequence version replaced XM_005250970.1. Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.29894.1, SRR1660807.54780.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END##

ATGATATCTA AGGAAAAGAA AGCTGCATTG GAAAAGGAGC GAGAAGAACG GATAGCTGAA 
GCTGAAATTG AAAACTTAAC AGGAGCCAGA CATATGGAAA GTGAGAAACT TGCTCAAATA 
TTGGCAGCTA GACAGTTAGA AATTAAACAG ATTCCATCTG ATGGCCACTG TATGTATAAA 
GCCATTGAAG ATCAACTGAA AGAAAAGGAT TGTGCTCTGA CTGTGGTTGC CTTGAGAAGT 
CAGACCGCTG AGTATATGCA AAGCCATGTG GAAGACTTTC TGCCATTTTT AACAAACCCT 
AATACAGGAG ATATGTATAC TCCAGAAGAA TTTCAGAAGT ACTGTGAAGA TATTGTAAAC 
ACAGCTGCAT GGGGAGGTCA GCTTGAGCTA AGAGCTCTGT CTCACATTTT ACAAACACCA 
ATAGAGATAA TACAGGCAGA TTCTCCTCCC ATTATAGTTG GTGAAGAATA TTCAAAAAAA 
CCACTAATAC TTGTATATAT GAGACATGCA TATGGCTTAG GAGAACATTA TAATTCGGTT 
ACACGGTTGG TAAACATAGT TACTGAAAAT TGCAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001273674.1
CDS	633..1211
Translation	MISKEKKAALEKEREERIAEAEIENLTGARHMESEKLAQILAARQLEIKQIPSDGHCMYKAIEDQLKEKDCALTVVALRSQTAEYMQSHVEDFLPFLTNPNTGDMYTPEEFQKYCEDIVNTAAWGGQLELRALSHILQTPIEIIQADSPPIIVGEEYSKKPLILVYMRHAYGLGEHYNSVTRLVNIVTENCS

Target ORF information:

RefSeq Version	NM_001286745.1
Organism	Homo sapiens(human)
Definition	Homo sapiens OTU domain containing 6B (OTUD6B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001286745.1

ORF Insert Sequence:

ATGATATCTA AGGAAAAGAA AGCTGCATTG GAAAAGGAGC GAGAAGAACG GATAGCTGAA 
GCTGAAATTG AAAACTTAAC AGGAGCCAGA CATATGGAAA GTGAGAAACT TGCTCAAATA 
TTGGCAGCTA GACAGTTAGA AATTAAACAG ATTCCATCTG ATGGCCACTG TATGTATAAA 
GCCATTGAAG ATCAACTGAA AGAAAAGGAT TGTGCTCTGA CTGTGGTTGC CTTGAGAAGT 
CAGACCGCTG AGTATATGCA AAGCCATGTG GAAGACTTTC TGCCATTTTT AACAAACCCT 
AATACAGGAG ATATGTATAC TCCAGAAGAA TTTCAGAAGT ACTGTGAAGA TATTGTAAAC 
ACAGCTGCAT GGGGAGGTCA GCTTGAGCTA AGAGCTCTGT CTCACATTTT ACAAACACCA 
ATAGAGATAA TACAGGCAGA TTCTCCTCCC ATTATAGTTG GTGAAGAATA TTCAAAAAAA 
CCACTAATAC TTGTATATAT GAGACATGCA TATGGCTTAG GAGAACATTA TAATTCGGTT 
ACACGGTTGG TAAACATAGT TACTGAAAAT TGCAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OTUD6B ( NM_016023.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057107.4 Homo sapiens OTU domain containing 6B (OTUD6B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu107066
Clone ID Related Accession (Same CDS sequence)	NM_016023.4 , NM_016023.5
Accession Version	NM_016023.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 882bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1551196800000
Organism	Homo sapiens(human)
Product	deubiquitinase OTUD6B isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA034027.1, BC029760.1, BI712470.1 and AA748163.1. On Jul 13, 2018 this sequence version replaced NM_016023.3. Transcript Variant: This variant (1) encodes the longer isoform (1). CCDS Note: The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. ##Evidence-Data-START## Transcript exon combination :: BX647772.1, BC029760.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGCGG TATTGACCGA AGAGCTTGAT GAGGAAGAGC AGCTGCTGAG AAGGCATCGC 
AAAGAGAAGA AGGAGTTGCA AGCCAAAATT CAGGGCATGA AGAATGCTGT TCCCAAGAAT 
GACAAGAAGA GGAGGAAGCA ACTCACCGAA GATGTGGCCA AGTTGGAAAA AGAAATGGAA 
CAGAAACATA GAGAGGAACT GGAGCAATTG AAGCTGACTA CTAAGGAGAA TAAGATAGAT 
TCTGTTGCTG TTAACATTTC AAACTTGGTG CTTGAGAATC AGCCACCTCG GATATCAAAA 
GCACAAAAGA GACGGGAAAA GAAAGCTGCA TTGGAAAAGG AGCGAGAAGA ACGGATAGCT 
GAAGCTGAAA TTGAAAACTT AACAGGAGCC AGACATATGG AAAGTGAGAA ACTTGCTCAA 
ATATTGGCAG CTAGACAGTT AGAAATTAAA CAGATTCCAT CTGATGGCCA CTGTATGTAT 
AAAGCCATTG AAGATCAACT GAAAGAAAAG GATTGTGCTC TGACTGTGGT TGCCTTGAGA 
AGTCAGACCG CTGAGTATAT GCAAAGCCAT GTGGAAGACT TTCTGCCATT TTTAACAAAC 
CCTAATACAG GAGATATGTA TACTCCAGAA GAATTTCAGA AGTACTGTGA AGATATTGTA 
AACACAGCTG CATGGGGAGG TCAGCTTGAG CTAAGAGCTC TGTCTCACAT TTTACAAACA 
CCAATAGAGA TAATACAGGC AGATTCTCCT CCCATTATAG TTGGTGAAGA ATATTCAAAA 
AAACCACTAA TACTTGTATA TATGAGACAT GCATATGGCT TAGGAGAACA TTATAATTCG 
GTTACACGGT TGGTAAACAT AGTTACTGAA AATTGCAGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057107.4
CDS	42..923
Translation	MEAVLTEELDEEEQLLRRHRKEKKELQAKIQGMKNAVPKNDKKRRKQLTEDVAKLEKEMEQKHREELEQLKLTTKENKIDSVAVNISNLVLENQPPRISKAQKRREKKAALEKEREERIAEAEIENLTGARHMESEKLAQILAARQLEIKQIPSDGHCMYKAIEDQLKEKDCALTVVALRSQTAEYMQSHVEDFLPFLTNPNTGDMYTPEEFQKYCEDIVNTAAWGGQLELRALSHILQTPIEIIQADSPPIIVGEEYSKKPLILVYMRHAYGLGEHYNSVTRLVNIVTENCS

Target ORF information:

RefSeq Version	NM_016023.4
Organism	Homo sapiens(human)
Definition	Homo sapiens OTU domain containing 6B (OTUD6B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016023.4

ORF Insert Sequence:

ATGGAGGCGG TATTGACCGA AGAGCTTGAT GAGGAAGAGC AGCTGCTGAG AAGGCATCGC 
AAAGAGAAGA AGGAGTTGCA AGCCAAAATT CAGGGCATGA AGAATGCTGT TCCCAAGAAT 
GACAAGAAGA GGAGGAAGCA ACTCACCGAA GATGTGGCCA AGTTGGAAAA AGAAATGGAA 
CAGAAACATA GAGAGGAACT GGAGCAATTG AAGCTGACTA CTAAGGAGAA TAAGATAGAT 
TCTGTTGCTG TTAACATTTC AAACTTGGTG CTTGAGAATC AGCCACCTCG GATATCAAAA 
GCACAAAAGA GACGGGAAAA GAAAGCTGCA TTGGAAAAGG AGCGAGAAGA ACGGATAGCT 
GAAGCTGAAA TTGAAAACTT AACAGGAGCC AGACATATGG AAAGTGAGAA ACTTGCTCAA 
ATATTGGCAG CTAGACAGTT AGAAATTAAA CAGATTCCAT CTGATGGCCA CTGTATGTAT 
AAAGCCATTG AAGATCAACT GAAAGAAAAG GATTGTGCTC TGACTGTGGT TGCCTTGAGA 
AGTCAGACCG CTGAGTATAT GCAAAGCCAT GTGGAAGACT TTCTGCCATT TTTAACAAAC 
CCTAATACAG GAGATATGTA TACTCCAGAA GAATTTCAGA AGTACTGTGA AGATATTGTA 
AACACAGCTG CATGGGGAGG TCAGCTTGAG CTAAGAGCTC TGTCTCACAT TTTACAAACA 
CCAATAGAGA TAATACAGGC AGATTCTCCT CCCATTATAG TTGGTGAAGA ATATTCAAAA 
AAACCACTAA TACTTGTATA TATGAGACAT GCATATGGCT TAGGAGAACA TTATAATTCG 
GTTACACGGT TGGTAAACAT AGTTACTGAA AATTGCAGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OTUD6B ( NM_016023.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_057107.4 Homo sapiens OTU deubiquitinase 6B (OTUD6B), transcript variant 1, mRNA.

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CloneID	OHu107066
Clone ID Related Accession (Same CDS sequence)	NM_016023.4 , NM_016023.5
Accession Version	NM_016023.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 882bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571500800000
Organism	Homo sapiens(human)
Product	deubiquitinase OTUD6B isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA034027.1, BC029760.1, BI712470.1 and AA748163.1. On May 17, 2019 this sequence version replaced NM_016023.4. Transcript Variant: This variant (1) encodes the longer isoform (1). CCDS Note: The coding region has been updated to shorten the N-terminus to one that is more supported by conservation. ##Evidence-Data-START## Transcript exon combination :: BC029760.1, BX647772.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000404789.8/ ENSP00000384190.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGAGGCGG TATTGACCGA AGAGCTTGAT GAGGAAGAGC AGCTGCTGAG AAGGCATCGC 
AAAGAGAAGA AGGAGTTGCA AGCCAAAATT CAGGGCATGA AGAATGCTGT TCCCAAGAAT 
GACAAGAAGA GGAGGAAGCA ACTCACCGAA GATGTGGCCA AGTTGGAAAA AGAAATGGAA 
CAGAAACATA GAGAGGAACT GGAGCAATTG AAGCTGACTA CTAAGGAGAA TAAGATAGAT 
TCTGTTGCTG TTAACATTTC AAACTTGGTG CTTGAGAATC AGCCACCTCG GATATCAAAA 
GCACAAAAGA GACGGGAAAA GAAAGCTGCA TTGGAAAAGG AGCGAGAAGA ACGGATAGCT 
GAAGCTGAAA TTGAAAACTT AACAGGAGCC AGACATATGG AAAGTGAGAA ACTTGCTCAA 
ATATTGGCAG CTAGACAGTT AGAAATTAAA CAGATTCCAT CTGATGGCCA CTGTATGTAT 
AAAGCCATTG AAGATCAACT GAAAGAAAAG GATTGTGCTC TGACTGTGGT TGCCTTGAGA 
AGTCAGACCG CTGAGTATAT GCAAAGCCAT GTGGAAGACT TTCTGCCATT TTTAACAAAC 
CCTAATACAG GAGATATGTA TACTCCAGAA GAATTTCAGA AGTACTGTGA AGATATTGTA 
AACACAGCTG CATGGGGAGG TCAGCTTGAG CTAAGAGCTC TGTCTCACAT TTTACAAACA 
CCAATAGAGA TAATACAGGC AGATTCTCCT CCCATTATAG TTGGTGAAGA ATATTCAAAA 
AAACCACTAA TACTTGTATA TATGAGACAT GCATATGGCT TAGGAGAACA TTATAATTCG 
GTTACACGGT TGGTAAACAT AGTTACTGAA AATTGCAGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057107.4
CDS	42..923
Translation	MEAVLTEELDEEEQLLRRHRKEKKELQAKIQGMKNAVPKNDKKRRKQLTEDVAKLEKEMEQKHREELEQLKLTTKENKIDSVAVNISNLVLENQPPRISKAQKRREKKAALEKEREERIAEAEIENLTGARHMESEKLAQILAARQLEIKQIPSDGHCMYKAIEDQLKEKDCALTVVALRSQTAEYMQSHVEDFLPFLTNPNTGDMYTPEEFQKYCEDIVNTAAWGGQLELRALSHILQTPIEIIQADSPPIIVGEEYSKKPLILVYMRHAYGLGEHYNSVTRLVNIVTENCS

Target ORF information:

RefSeq Version	NM_016023.5
Organism	Homo sapiens(human)
Definition	Homo sapiens OTU deubiquitinase 6B (OTUD6B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016023.5

ORF Insert Sequence:

ATGGAGGCGG TATTGACCGA AGAGCTTGAT GAGGAAGAGC AGCTGCTGAG AAGGCATCGC 
AAAGAGAAGA AGGAGTTGCA AGCCAAAATT CAGGGCATGA AGAATGCTGT TCCCAAGAAT 
GACAAGAAGA GGAGGAAGCA ACTCACCGAA GATGTGGCCA AGTTGGAAAA AGAAATGGAA 
CAGAAACATA GAGAGGAACT GGAGCAATTG AAGCTGACTA CTAAGGAGAA TAAGATAGAT 
TCTGTTGCTG TTAACATTTC AAACTTGGTG CTTGAGAATC AGCCACCTCG GATATCAAAA 
GCACAAAAGA GACGGGAAAA GAAAGCTGCA TTGGAAAAGG AGCGAGAAGA ACGGATAGCT 
GAAGCTGAAA TTGAAAACTT AACAGGAGCC AGACATATGG AAAGTGAGAA ACTTGCTCAA 
ATATTGGCAG CTAGACAGTT AGAAATTAAA CAGATTCCAT CTGATGGCCA CTGTATGTAT 
AAAGCCATTG AAGATCAACT GAAAGAAAAG GATTGTGCTC TGACTGTGGT TGCCTTGAGA 
AGTCAGACCG CTGAGTATAT GCAAAGCCAT GTGGAAGACT TTCTGCCATT TTTAACAAAC 
CCTAATACAG GAGATATGTA TACTCCAGAA GAATTTCAGA AGTACTGTGA AGATATTGTA 
AACACAGCTG CATGGGGAGG TCAGCTTGAG CTAAGAGCTC TGTCTCACAT TTTACAAACA 
CCAATAGAGA TAATACAGGC AGATTCTCCT CCCATTATAG TTGGTGAAGA ATATTCAAAA 
AAACCACTAA TACTTGTATA TATGAGACAT GCATATGGCT TAGGAGAACA TTATAATTCG 
GTTACACGGT TGGTAAACAT AGTTACTGAA AATTGCAGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OTUD6B ( XM_011517129.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011515431.2 Homo sapiens OTU deubiquitinase 6B (OTUD6B), transcript variant X1, mRNA.

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CloneID	OHu07802
Clone ID Related Accession (Same CDS sequence)	XM_011517129.2 , NM_001286745.2 , NM_001286745.1
Accession Version	XM_011517129.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	deubiquitinase OTUD6B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011517129.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATATCTA AGGAAAAGAA AGCTGCATTG GAAAAGGAGC GAGAAGAACG GATAGCTGAA 
GCTGAAATTG AAAACTTAAC AGGAGCCAGA CATATGGAAA GTGAGAAACT TGCTCAAATA 
TTGGCAGCTA GACAGTTAGA AATTAAACAG ATTCCATCTG ATGGCCACTG TATGTATAAA 
GCCATTGAAG ATCAACTGAA AGAAAAGGAT TGTGCTCTGA CTGTGGTTGC CTTGAGAAGT 
CAGACCGCTG AGTATATGCA AAGCCATGTG GAAGACTTTC TGCCATTTTT AACAAACCCT 
AATACAGGAG ATATGTATAC TCCAGAAGAA TTTCAGAAGT ACTGTGAAGA TATTGTAAAC 
ACAGCTGCAT GGGGAGGTCA GCTTGAGCTA AGAGCTCTGT CTCACATTTT ACAAACACCA 
ATAGAGATAA TACAGGCAGA TTCTCCTCCC ATTATAGTTG GTGAAGAATA TTCAAAAAAA 
CCACTAATAC TTGTATATAT GAGACATGCA TATGGCTTAG GAGAACATTA TAATTCGGTT 
ACACGGTTGG TAAACATAGT TACTGAAAAT TGCAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011515431.2
CDS	520..1098
Translation	MISKEKKAALEKEREERIAEAEIENLTGARHMESEKLAQILAARQLEIKQIPSDGHCMYKAIEDQLKEKDCALTVVALRSQTAEYMQSHVEDFLPFLTNPNTGDMYTPEEFQKYCEDIVNTAAWGGQLELRALSHILQTPIEIIQADSPPIIVGEEYSKKPLILVYMRHAYGLGEHYNSVTRLVNIVTENCS

Target ORF information:

RefSeq Version	XM_011517129.2
Organism	Homo sapiens(human)
Definition	Homo sapiens OTU deubiquitinase 6B (OTUD6B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011517129.2

ORF Insert Sequence:

ATGATATCTA AGGAAAAGAA AGCTGCATTG GAAAAGGAGC GAGAAGAACG GATAGCTGAA 
GCTGAAATTG AAAACTTAAC AGGAGCCAGA CATATGGAAA GTGAGAAACT TGCTCAAATA 
TTGGCAGCTA GACAGTTAGA AATTAAACAG ATTCCATCTG ATGGCCACTG TATGTATAAA 
GCCATTGAAG ATCAACTGAA AGAAAAGGAT TGTGCTCTGA CTGTGGTTGC CTTGAGAAGT 
CAGACCGCTG AGTATATGCA AAGCCATGTG GAAGACTTTC TGCCATTTTT AACAAACCCT 
AATACAGGAG ATATGTATAC TCCAGAAGAA TTTCAGAAGT ACTGTGAAGA TATTGTAAAC 
ACAGCTGCAT GGGGAGGTCA GCTTGAGCTA AGAGCTCTGT CTCACATTTT ACAAACACCA 
ATAGAGATAA TACAGGCAGA TTCTCCTCCC ATTATAGTTG GTGAAGAATA TTCAAAAAAA 
CCACTAATAC TTGTATATAT GAGACATGCA TATGGCTTAG GAGAACATTA TAATTCGGTT 
ACACGGTTGG TAAACATAGT TACTGAAAAT TGCAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Biallelic Variants in OTUD6B Cause an Intellectual Disability Syndrome Associated with Seizures and Dysmorphic Features.
American journal of human genetics100(4)676-688(2017 Apr)
Santiago-Sim T,Burrage LC,Ebstein F,Tokita MJ,Miller M,Bi W,Braxton AA,Rosenfeld JA,Shahrour M,Lehmann A,Cogné B,Küry S,Besnard T,Isidor B,Bézieau S,Hazart I,Nagakura H,Immken LL,Littlejohn RO,Roeder E,,Kara B,Hardies K,Weckhuysen S,May P,Lemke JR,Elpeleg O,Abu-Libdeh B,James KN,Silhavy JL,Issa MY,Zaki MS,Gleeson JG,Seavitt JR,Dickinson ME,Ljungberg MC,Wells S,Johnson SJ,Teboul L,Eng CM,Yang Y,Kloetzel PM,Heaney JD,Walkiewicz MA

Deubiquitinase OTUD6B Isoforms Are Important Regulators of Growth and Proliferation.
Molecular cancer research : MCR15(2)117-127(2017 02)
Sobol A,Askonas C,Alani S,Weber MJ,Ananthanarayanan V,Osipo C,Bocchetta M

Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation.
PloS one6(1)e14514(2011 Jan)
Xu Z,Zheng Y,Zhu Y,Kong X,Hu L

Defining the human deubiquitinating enzyme interaction landscape.
Cell138(2)389-403(2009 Jul)
Sowa ME,Bennett EJ,Gygi SP,Harper JW

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OTUD6B cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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