PAX4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PAX4
Entrez Gene ID	5078
Full Name	paired box 4
Synonyms	KPD,MODY9
General protein information	Preferred Names paired box 4 Names paired box protein Pax-4 paired box gene 4 paired domain gene 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q32.1
Summary	This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells. [provided by RefSeq, Jul 2008].
Disorder MIM:	167413
Disorder Html:	Maturity-onset diabetes of the young, type IX, 612225 (3); Diabetes mellitus, type 2, 125853 (3); {Diabetes mellitus, ketosis-prone, susceptibility to}, 612227 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001366110.1	NP_001353039.1	paired box protein Pax-4 isoform 1
NM_006193.2	NP_006184.2	paired box protein Pax-4
NM_001366111.1	NP_001353040.1	paired box protein Pax-4 isoform 2
XM_011516276.2	XP_011514578.1	paired box protein Pax-4 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PAX4	XP_001151306.1
Bos taurus (cattle)	PAX4	XP_003586045.2
Homo sapiens (human)	PAX4	NP_006184.2
Rattus norvegicus (Norway rat)	Pax4	NP_113987.1
Xenopus tropicalis (tropical clawed frog)	LOC101733204	XP_004913250.1
Macaca mulatta (Rhesus monkey)	PAX4	XP_001090108.2
Canis lupus familiaris (dog)	PAX4	XP_539387.4
Mus musculus (house mouse)	Pax4	NP_035168.1

Gene Ontology
Bibliography

Related articles in PubMed

Nonsynonymous Variants in
Kwak SH, Chae J, Lee S, Choi S, Koo BK, Yoon JW, Park JH, Cho B, Moon MK, Lim S, Cho YM, Moon S, Kim YJ, Han S, Hwang MY, Cho YS, Lee MS, Jang HC, Kang HM, Park T, Cho NH, Kim K, Kim JI, Park KS
Diabetes67(9)1892-1902(2018 09)

The rs10229583 polymorphism near paired box gene 4 is associated with gestational diabetes mellitus in Chinese women.
Xu T, Shi Y, Liu J, Liu Y, Zhu A, Xie C, Zhang Y, Chen Y, Ren L
The Journal of international medical research46(1)115-121(2018 Jan)

Exome-chip association analysis reveals an Asian-specific missense variant in PAX4 associated with type 2 diabetes in Chinese individuals.
Cheung CY, Tang CS, Xu A, Lee CH, Au KW, Xu L, Fong CH, Kwok KH, Chow WS, Woo YC, Yuen MM, Hai JS, Jin YL, Cheung BM, Tan KC, Cherny SS, Zhu F, Zhu T, Thomas GN, Cheng KK, Jiang CQ, Lam TH, Tse HF, Sham PC, Lam KS
Diabetologia60(1)107-115(2017 01)

PAX4 R192H and P321H polymorphisms in type 2 diabetes and their functional defects.
Sujjitjoon J, Kooptiwut S, Chongjaroen N, Semprasert N, Hanchang W, Chanprasert K, Tangjittipokin W, Yenchitsomanus PT, Plengvidhya N
Journal of human genetics61(11)943-949(2016 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PAX4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PAX4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu106897	NM_001366111.1 Latest version!	Homo sapiens paired box 4 (PAX4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu59494	NM_001366110.1 Latest version!	Homo sapiens paired box 4 (PAX4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu59494	XM_011516276.2 Latest version!	Homo sapiens paired box 4 (PAX4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu27435	NM_006193.2 Latest version!	Homo sapiens paired box 4 (PAX4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PAX4 ( NM_001366111.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001353040.1 Homo sapiens paired box 4 (PAX4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu106897
Clone ID Related Accession (Same CDS sequence)	NM_001366111.1
Accession Version	NM_001366111.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1047bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1568995200000
Organism	Homo sapiens(human)
Product	paired box protein Pax-4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC073934.1 and AB008913.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB008913.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151119 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCATCAGG ACGGGATCAG CAGCATGAAC CAGCTTGGGG GGCTCTTTGT GAATGGCCGG 
CCCCTGCCTC TGGATACCCG GCAGCAGATT GTGCGGCTAG CAGTCAGTGG AATGCGGCCC 
TGTGACATCT CACGGATCCT TAAGGTATCT AATGGCTGTG TGAGCAAGAT CCTAGGGCGT 
TACTACCGCA CAGGTGTCTT GGAGCCAAAG GGCATTGGGG GAAGCAAGCC ACGGCTGGCT 
ACACCCCCTG TGGTGGCTCG AATTGCCCAG CTGAAGGGTG AGTGTCCAGC CCTCTTTGCC 
TGGGAAATCC AACGCCAGCT TTGTGCTGAA GGGCTTTGCA CCCAGGACAA GACTCCCAGT 
GTCTCCTCCA TCAACCGAGT CCTGCGGGCA TTACAGGAGG ACCAGGGACT ACCGTGCACA 
CGGCTCAGGT CACCAGCTGT TTTGGCTCCA GCTGTCCTCA CTCCCCATAG TGGCTCTGAG 
ACTCCCCGGG GTACCCACCC AGGGACCGGC CACCGGAATC GGACTATCTT CTCCCCAAGC 
CAAGCAGAGG CACTGGAGAA AGAGTTCCAG CGTGGGCAGT ATCCTGATTC AGTGGCCCGT 
GGAAAGCTGG CTACTGCCAC CTCTCTGCCT GAGGACACGG TGAGGGTCTG GTTTTCCAAC 
AGAAGAGCCA AATGGCGTCG GCAAGAGAAG CTCAAGTGGG AAATGCAGCT GCCAGGTGCT 
TCCCAGGGGC TGACTGTACC AAGGGTTGCC CCAGGAATCA TCTCTGCACA GCAGTCCCCT 
GGCAGTGTGC CCACAGCAGC CCTGCCTGCC CTGGAACCAC TGGGTCCCTC CTGCTATCAG 
CTGTGCTGGG CAACAGCACC AGAAAGGTGT CTGAGTGACA CCCCACCTAA AGCCTGTCTC 
AAGCCCTGCT GGGACTGTGG CTCCTTCCTC CTTCCTGTGA TTGCTCCCTC CTGTGTGGAC 
GTTGCCTGGC CCTGCCTCGA TGCCTCTCTG GCGCATCACC TGATTGGAGG GGCTGGTAAA 
GCAACACCCA CCCACTTCTC ACACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001353040.1
CDS	100..1146
Translation	MHQDGISSMNQLGGLFVNGRPLPLDTRQQIVRLAVSGMRPCDISRILKVSNGCVSKILGRYYRTGVLEPKGIGGSKPRLATPPVVARIAQLKGECPALFAWEIQRQLCAEGLCTQDKTPSVSSINRVLRALQEDQGLPCTRLRSPAVLAPAVLTPHSGSETPRGTHPGTGHRNRTIFSPSQAEALEKEFQRGQYPDSVARGKLATATSLPEDTVRVWFSNRRAKWRRQEKLKWEMQLPGASQGLTVPRVAPGIISAQQSPGSVPTAALPALEPLGPSCYQLCWATAPERCLSDTPPKACLKPCWDCGSFLLPVIAPSCVDVAWPCLDASLAHHLIGGAGKATPTHFSH

Target ORF information:

RefSeq Version	NM_001366111.1
Organism	Homo sapiens(human)
Definition	Homo sapiens paired box 4 (PAX4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001366111.1

ORF Insert Sequence:

ATGCATCAGG ACGGGATCAG CAGCATGAAC CAGCTTGGGG GGCTCTTTGT GAATGGCCGG 
CCCCTGCCTC TGGATACCCG GCAGCAGATT GTGCGGCTAG CAGTCAGTGG AATGCGGCCC 
TGTGACATCT CACGGATCCT TAAGGTATCT AATGGCTGTG TGAGCAAGAT CCTAGGGCGT 
TACTACCGCA CAGGTGTCTT GGAGCCAAAG GGCATTGGGG GAAGCAAGCC ACGGCTGGCT 
ACACCCCCTG TGGTGGCTCG AATTGCCCAG CTGAAGGGTG AGTGTCCAGC CCTCTTTGCC 
TGGGAAATCC AACGCCAGCT TTGTGCTGAA GGGCTTTGCA CCCAGGACAA GACTCCCAGT 
GTCTCCTCCA TCAACCGAGT CCTGCGGGCA TTACAGGAGG ACCAGGGACT ACCGTGCACA 
CGGCTCAGGT CACCAGCTGT TTTGGCTCCA GCTGTCCTCA CTCCCCATAG TGGCTCTGAG 
ACTCCCCGGG GTACCCACCC AGGGACCGGC CACCGGAATC GGACTATCTT CTCCCCAAGC 
CAAGCAGAGG CACTGGAGAA AGAGTTCCAG CGTGGGCAGT ATCCTGATTC AGTGGCCCGT 
GGAAAGCTGG CTACTGCCAC CTCTCTGCCT GAGGACACGG TGAGGGTCTG GTTTTCCAAC 
AGAAGAGCCA AATGGCGTCG GCAAGAGAAG CTCAAGTGGG AAATGCAGCT GCCAGGTGCT 
TCCCAGGGGC TGACTGTACC AAGGGTTGCC CCAGGAATCA TCTCTGCACA GCAGTCCCCT 
GGCAGTGTGC CCACAGCAGC CCTGCCTGCC CTGGAACCAC TGGGTCCCTC CTGCTATCAG 
CTGTGCTGGG CAACAGCACC AGAAAGGTGT CTGAGTGACA CCCCACCTAA AGCCTGTCTC 
AAGCCCTGCT GGGACTGTGG CTCCTTCCTC CTTCCTGTGA TTGCTCCCTC CTGTGTGGAC 
GTTGCCTGGC CCTGCCTCGA TGCCTCTCTG GCGCATCACC TGATTGGAGG GGCTGGTAAA 
GCAACACCCA CCCACTTCTC ACACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PAX4 ( NM_001366110.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001353039.1 Homo sapiens paired box 4 (PAX4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu59494
Clone ID Related Accession (Same CDS sequence)	NM_001366110.1 , XM_011516276.2
Accession Version	NM_001366110.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571500800000
Organism	Homo sapiens(human)
Product	paired box protein Pax-4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC073934.1. This sequence is a reference standard in the RefSeqGene project. On Sep 22, 2018 this sequence version replaced XM_011516276.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology MANE Ensembl match :: ENST00000639438.3/ ENSP00000491782.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCATCAGG ACGGGATCAG CAGCATGAAC CAGCTTGGGG GGCTCTTTGT GAATGGCCGG 
CCCCTGCCTC TGGATACCCG GCAGCAGATT GTGCGGCTAG CAGTCAGTGG AATGCGGCCC 
TGTGACATCT CACGGATCCT TAAGGTATCT AATGGCTGTG TGAGCAAGAT CCTAGGGCGT 
TACTACCGCA CAGGTGTCTT GGAGCCAAAG GGCATTGGGG GAAGCAAGCC ACGGCTGGCT 
ACACCCCCTG TGGTGGCTCG AATTGCCCAG CTGAAGGGTG AGTGTCCAGC CCTCTTTGCC 
TGGGAAATCC AACGCCAGCT TTGTGCTGAA GGGCTTTGCA CCCAGGACAA GACTCCCAGT 
GTCTCCTCCA TCAACCGAGT CCTGCGGGCA TTACAGGAGG ACCAGGGACT ACCGTGCACA 
CGGCTCAGGT CACCAGCTGT TTTGGCTCCA GCTGTCCTCA CTCCCCATAG TGGCTCTGAG 
ACTCCCCGGG GTACCCACCC AGGGACCGGC CACCGGAATC GGACTATCTT CTCCCCAAGC 
CAAGCAGAGG CACTGGAGAA AGAGTTCCAG CGTGGGCAGT ATCCTGATTC AGTGGCCCGT 
GGAAAGCTGG CTACTGCCAC CTCTCTGCCT GAGGACACGG TGAGGGTCTG GTTTTCCAAC 
AGAAGAGCCA AATGGCGTCG GCAAGAGAAG CTCAAGTGGG AAATGCAGCT GCCAGGTGCT 
TCCCAGGGGC TGACTGTACC AAGGGTTGCC CCAGGAATCA TCTCTGCACA GCAGTCCCCT 
GGCAGTGTGC CCACAGCAGC CCTGCCTGCC CTGGAACCAC TGGGTCCCTC CTGCTATCAG 
CTGTGCTGGG CAACAGCACC AGAAAGGTGT CTGAGTGACA CCCCACCTAA AGCCTGTCTC 
AAGCCCTGCT GGGGCCACTT GCCCCCACAG CCGAATTCCC TGGACTCAGG ACTGCTTTGC 
CTTCCTTGCC CTTCCTCCCA CTGTCACCTG GCCAGTCTTA GTGGCTCTCA GGCCCTGCTC 
TGGCCTGGCT GCCCACTACT GTATGGCTTG GAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001353039.1
CDS	407..1462
Translation	MHQDGISSMNQLGGLFVNGRPLPLDTRQQIVRLAVSGMRPCDISRILKVSNGCVSKILGRYYRTGVLEPKGIGGSKPRLATPPVVARIAQLKGECPALFAWEIQRQLCAEGLCTQDKTPSVSSINRVLRALQEDQGLPCTRLRSPAVLAPAVLTPHSGSETPRGTHPGTGHRNRTIFSPSQAEALEKEFQRGQYPDSVARGKLATATSLPEDTVRVWFSNRRAKWRRQEKLKWEMQLPGASQGLTVPRVAPGIISAQQSPGSVPTAALPALEPLGPSCYQLCWATAPERCLSDTPPKACLKPCWGHLPPQPNSLDSGLLCLPCPSSHCHLASLSGSQALLWPGCPLLYGLE

Target ORF information:

RefSeq Version	NM_001366110.1
Organism	Homo sapiens(human)
Definition	Homo sapiens paired box 4 (PAX4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001366110.1

ORF Insert Sequence:

ATGCATCAGG ACGGGATCAG CAGCATGAAC CAGCTTGGGG GGCTCTTTGT GAATGGCCGG 
CCCCTGCCTC TGGATACCCG GCAGCAGATT GTGCGGCTAG CAGTCAGTGG AATGCGGCCC 
TGTGACATCT CACGGATCCT TAAGGTATCT AATGGCTGTG TGAGCAAGAT CCTAGGGCGT 
TACTACCGCA CAGGTGTCTT GGAGCCAAAG GGCATTGGGG GAAGCAAGCC ACGGCTGGCT 
ACACCCCCTG TGGTGGCTCG AATTGCCCAG CTGAAGGGTG AGTGTCCAGC CCTCTTTGCC 
TGGGAAATCC AACGCCAGCT TTGTGCTGAA GGGCTTTGCA CCCAGGACAA GACTCCCAGT 
GTCTCCTCCA TCAACCGAGT CCTGCGGGCA TTACAGGAGG ACCAGGGACT ACCGTGCACA 
CGGCTCAGGT CACCAGCTGT TTTGGCTCCA GCTGTCCTCA CTCCCCATAG TGGCTCTGAG 
ACTCCCCGGG GTACCCACCC AGGGACCGGC CACCGGAATC GGACTATCTT CTCCCCAAGC 
CAAGCAGAGG CACTGGAGAA AGAGTTCCAG CGTGGGCAGT ATCCTGATTC AGTGGCCCGT 
GGAAAGCTGG CTACTGCCAC CTCTCTGCCT GAGGACACGG TGAGGGTCTG GTTTTCCAAC 
AGAAGAGCCA AATGGCGTCG GCAAGAGAAG CTCAAGTGGG AAATGCAGCT GCCAGGTGCT 
TCCCAGGGGC TGACTGTACC AAGGGTTGCC CCAGGAATCA TCTCTGCACA GCAGTCCCCT 
GGCAGTGTGC CCACAGCAGC CCTGCCTGCC CTGGAACCAC TGGGTCCCTC CTGCTATCAG 
CTGTGCTGGG CAACAGCACC AGAAAGGTGT CTGAGTGACA CCCCACCTAA AGCCTGTCTC 
AAGCCCTGCT GGGGCCACTT GCCCCCACAG CCGAATTCCC TGGACTCAGG ACTGCTTTGC 
CTTCCTTGCC CTTCCTCCCA CTGTCACCTG GCCAGTCTTA GTGGCTCTCA GGCCCTGCTC 
TGGCCTGGCT GCCCACTACT GTATGGCTTG GAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PAX4 ( XM_011516276.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011514578.1 Homo sapiens paired box 4 (PAX4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu59494
Clone ID Related Accession (Same CDS sequence)	NM_001366110.1 , XM_011516276.2
Accession Version	XM_011516276.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1465056000000
Organism	Homo sapiens(human)
Product	paired box protein Pax-4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011516276.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCATCAGG ACGGGATCAG CAGCATGAAC CAGCTTGGGG GGCTCTTTGT GAATGGCCGG 
CCCCTGCCTC TGGATACCCG GCAGCAGATT GTGCGGCTAG CAGTCAGTGG AATGCGGCCC 
TGTGACATCT CACGGATCCT TAAGGTATCT AATGGCTGTG TGAGCAAGAT CCTAGGGCGT 
TACTACCGCA CAGGTGTCTT GGAGCCAAAG GGCATTGGGG GAAGCAAGCC ACGGCTGGCT 
ACACCCCCTG TGGTGGCTCG AATTGCCCAG CTGAAGGGTG AGTGTCCAGC CCTCTTTGCC 
TGGGAAATCC AACGCCAGCT TTGTGCTGAA GGGCTTTGCA CCCAGGACAA GACTCCCAGT 
GTCTCCTCCA TCAACCGAGT CCTGCGGGCA TTACAGGAGG ACCAGGGACT ACCGTGCACA 
CGGCTCAGGT CACCAGCTGT TTTGGCTCCA GCTGTCCTCA CTCCCCATAG TGGCTCTGAG 
ACTCCCCGGG GTACCCACCC AGGGACCGGC CACCGGAATC GGACTATCTT CTCCCCAAGC 
CAAGCAGAGG CACTGGAGAA AGAGTTCCAG CGTGGGCAGT ATCCTGATTC AGTGGCCCGT 
GGAAAGCTGG CTACTGCCAC CTCTCTGCCT GAGGACACGG TGAGGGTCTG GTTTTCCAAC 
AGAAGAGCCA AATGGCGTCG GCAAGAGAAG CTCAAGTGGG AAATGCAGCT GCCAGGTGCT 
TCCCAGGGGC TGACTGTACC AAGGGTTGCC CCAGGAATCA TCTCTGCACA GCAGTCCCCT 
GGCAGTGTGC CCACAGCAGC CCTGCCTGCC CTGGAACCAC TGGGTCCCTC CTGCTATCAG 
CTGTGCTGGG CAACAGCACC AGAAAGGTGT CTGAGTGACA CCCCACCTAA AGCCTGTCTC 
AAGCCCTGCT GGGGCCACTT GCCCCCACAG CCGAATTCCC TGGACTCAGG ACTGCTTTGC 
CTTCCTTGCC CTTCCTCCCA CTGTCACCTG GCCAGTCTTA GTGGCTCTCA GGCCCTGCTC 
TGGCCTGGCT GCCCACTACT GTATGGCTTG GAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011514578.1
CDS	457..1512
Translation	MHQDGISSMNQLGGLFVNGRPLPLDTRQQIVRLAVSGMRPCDISRILKVSNGCVSKILGRYYRTGVLEPKGIGGSKPRLATPPVVARIAQLKGECPALFAWEIQRQLCAEGLCTQDKTPSVSSINRVLRALQEDQGLPCTRLRSPAVLAPAVLTPHSGSETPRGTHPGTGHRNRTIFSPSQAEALEKEFQRGQYPDSVARGKLATATSLPEDTVRVWFSNRRAKWRRQEKLKWEMQLPGASQGLTVPRVAPGIISAQQSPGSVPTAALPALEPLGPSCYQLCWATAPERCLSDTPPKACLKPCWGHLPPQPNSLDSGLLCLPCPSSHCHLASLSGSQALLWPGCPLLYGLE

Target ORF information:

RefSeq Version	XM_011516276.2
Organism	Homo sapiens(human)
Definition	Homo sapiens paired box 4 (PAX4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011516276.2

ORF Insert Sequence:

ATGCATCAGG ACGGGATCAG CAGCATGAAC CAGCTTGGGG GGCTCTTTGT GAATGGCCGG 
CCCCTGCCTC TGGATACCCG GCAGCAGATT GTGCGGCTAG CAGTCAGTGG AATGCGGCCC 
TGTGACATCT CACGGATCCT TAAGGTATCT AATGGCTGTG TGAGCAAGAT CCTAGGGCGT 
TACTACCGCA CAGGTGTCTT GGAGCCAAAG GGCATTGGGG GAAGCAAGCC ACGGCTGGCT 
ACACCCCCTG TGGTGGCTCG AATTGCCCAG CTGAAGGGTG AGTGTCCAGC CCTCTTTGCC 
TGGGAAATCC AACGCCAGCT TTGTGCTGAA GGGCTTTGCA CCCAGGACAA GACTCCCAGT 
GTCTCCTCCA TCAACCGAGT CCTGCGGGCA TTACAGGAGG ACCAGGGACT ACCGTGCACA 
CGGCTCAGGT CACCAGCTGT TTTGGCTCCA GCTGTCCTCA CTCCCCATAG TGGCTCTGAG 
ACTCCCCGGG GTACCCACCC AGGGACCGGC CACCGGAATC GGACTATCTT CTCCCCAAGC 
CAAGCAGAGG CACTGGAGAA AGAGTTCCAG CGTGGGCAGT ATCCTGATTC AGTGGCCCGT 
GGAAAGCTGG CTACTGCCAC CTCTCTGCCT GAGGACACGG TGAGGGTCTG GTTTTCCAAC 
AGAAGAGCCA AATGGCGTCG GCAAGAGAAG CTCAAGTGGG AAATGCAGCT GCCAGGTGCT 
TCCCAGGGGC TGACTGTACC AAGGGTTGCC CCAGGAATCA TCTCTGCACA GCAGTCCCCT 
GGCAGTGTGC CCACAGCAGC CCTGCCTGCC CTGGAACCAC TGGGTCCCTC CTGCTATCAG 
CTGTGCTGGG CAACAGCACC AGAAAGGTGT CTGAGTGACA CCCCACCTAA AGCCTGTCTC 
AAGCCCTGCT GGGGCCACTT GCCCCCACAG CCGAATTCCC TGGACTCAGG ACTGCTTTGC 
CTTCCTTGCC CTTCCTCCCA CTGTCACCTG GCCAGTCTTA GTGGCTCTCA GGCCCTGCTC 
TGGCCTGGCT GCCCACTACT GTATGGCTTG GAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PAX4 ( NM_006193.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006184.2 Homo sapiens paired box 4 (PAX4), mRNA.

Price & Availability↑

CloneID	OHu27435
Clone ID Related Accession (Same CDS sequence)	NM_006193.2
Accession Version	NM_006193.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506787200000
Organism	Homo sapiens(human)
Product	paired box protein Pax-4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF043978.1 and AC073934.1. This sequence is a reference standard in the RefSeqGene project. On Mar 26, 2008 this sequence version replaced NM_006193.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because transcript sequence consistent with the reference genome assembly was not available for all regions of the RefSeq transcript. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF043978.1, BC074761.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151119 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACCAGC TTGGGGGGCT CTTTGTGAAT GGCCGGCCCC TGCCTCTGGA TACCCGGCAG 
CAGATTGTGC GGCTAGCAGT CAGTGGAATG CGGCCCTGTG ACATCTCACG GATCCTTAAG 
GTATCTAATG GCTGTGTGAG CAAGATCCTA GGGCGTTACT ACCGCACAGG TGTCTTGGAG 
CCAAAGGGCA TTGGGGGAAG CAAGCCACGG CTGGCTACAC CCCCTGTGGT GGCTCGAATT 
GCCCAGCTGA AGGGTGAGTG TCCAGCCCTC TTTGCCTGGG AAATCCAACG CCAGCTTTGT 
GCTGAAGGGC TTTGCACCCA GGACAAGACT CCCAGTGTCT CCTCCATCAA CCGAGTCCTG 
CGGGCATTAC AGGAGGACCA GGGACTACCG TGCACACGGC TCAGGTCACC AGCTGTTTTG 
GCTCCAGCTG TCCTCACTCC CCATAGTGGC TCTGAGACTC CCCGGGGTAC CCACCCAGGG 
ACCGGCCACC GGAATCGGAC TATCTTCTCC CCAAGCCAAG CAGAGGCACT GGAGAAAGAG 
TTCCAGCGTG GGCAGTATCC TGATTCAGTG GCCCGTGGAA AGCTGGCTAC TGCCACCTCT 
CTGCCTGAGG ACACGGTGAG GGTCTGGTTT TCCAACAGAA GAGCCAAATG GCGTCGGCAA 
GAGAAGCTCA AGTGGGAAAT GCAGCTGCCA GGTGCTTCCC AGGGGCTGAC TGTACCAAGG 
GTTGCCCCAG GAATCATCTC TGCACAGCAG TCCCCTGGCA GTGTGCCCAC AGCAGCCCTG 
CCTGCCCTGG AACCACTGGG TCCCTCCTGC TATCAGCTGT GCTGGGCAAC AGCACCAGAA 
AGGTGTCTGA GTGACACCCC ACCTAAAGCC TGTCTCAAGC CCTGCTGGGG CCACTTGCCC 
CCACAGCCGA ATTCCCTGGA CTCAGGACTG CTTTGCCTTC CTTGCCCTTC CTCCCACTGT 
CACCTGGCCA GTCTTAGTGG CTCTCAGGCC CTGCTCTGGC CTGGCTGCCC ACTACTGTAT 
GGCTTGGAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006184.2
CDS	207..1238
Translation	MNQLGGLFVNGRPLPLDTRQQIVRLAVSGMRPCDISRILKVSNGCVSKILGRYYRTGVLEPKGIGGSKPRLATPPVVARIAQLKGECPALFAWEIQRQLCAEGLCTQDKTPSVSSINRVLRALQEDQGLPCTRLRSPAVLAPAVLTPHSGSETPRGTHPGTGHRNRTIFSPSQAEALEKEFQRGQYPDSVARGKLATATSLPEDTVRVWFSNRRAKWRRQEKLKWEMQLPGASQGLTVPRVAPGIISAQQSPGSVPTAALPALEPLGPSCYQLCWATAPERCLSDTPPKACLKPCWGHLPPQPNSLDSGLLCLPCPSSHCHLASLSGSQALLWPGCPLLYGLE

Target ORF information:

RefSeq Version	NM_006193.2
Organism	Homo sapiens(human)
Definition	Homo sapiens paired box 4 (PAX4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006193.2

ORF Insert Sequence:

ATGAACCAGC TTGGGGGGCT CTTTGTGAAT GGCCGGCCCC TGCCTCTGGA TACCCGGCAG 
CAGATTGTGC GGCTAGCAGT CAGTGGAATG CGGCCCTGTG ACATCTCACG GATCCTTAAG 
GTATCTAATG GCTGTGTGAG CAAGATCCTA GGGCGTTACT ACCGCACAGG TGTCTTGGAG 
CCAAAGGGCA TTGGGGGAAG CAAGCCACGG CTGGCTACAC CCCCTGTGGT GGCTCGAATT 
GCCCAGCTGA AGGGTGAGTG TCCAGCCCTC TTTGCCTGGG AAATCCAACG CCAGCTTTGT 
GCTGAAGGGC TTTGCACCCA GGACAAGACT CCCAGTGTCT CCTCCATCAA CCGAGTCCTG 
CGGGCATTAC AGGAGGACCA GGGACTACCG TGCACACGGC TCAGGTCACC AGCTGTTTTG 
GCTCCAGCTG TCCTCACTCC CCATAGTGGC TCTGAGACTC CCCGGGGTAC CCACCCAGGG 
ACCGGCCACC GGAATCGGAC TATCTTCTCC CCAAGCCAAG CAGAGGCACT GGAGAAAGAG 
TTCCAGCGTG GGCAGTATCC TGATTCAGTG GCCCGTGGAA AGCTGGCTAC TGCCACCTCT 
CTGCCTGAGG ACACGGTGAG GGTCTGGTTT TCCAACAGAA GAGCCAAATG GCGTCGGCAA 
GAGAAGCTCA AGTGGGAAAT GCAGCTGCCA GGTGCTTCCC AGGGGCTGAC TGTACCAAGG 
GTTGCCCCAG GAATCATCTC TGCACAGCAG TCCCCTGGCA GTGTGCCCAC AGCAGCCCTG 
CCTGCCCTGG AACCACTGGG TCCCTCCTGC TATCAGCTGT GCTGGGCAAC AGCACCAGAA 
AGGTGTCTGA GTGACACCCC ACCTAAAGCC TGTCTCAAGC CCTGCTGGGG CCACTTGCCC 
CCACAGCCGA ATTCCCTGGA CTCAGGACTG CTTTGCCTTC CTTGCCCTTC CTCCCACTGT 
CACCTGGCCA GTCTTAGTGG CTCTCAGGCC CTGCTCTGGC CTGGCTGCCC ACTACTGTAT 
GGCTTGGAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nonsynonymous Variants in
Diabetes67(9)1892-1902(2018 09)
Kwak SH,Chae J,Lee S,Choi S,Koo BK,Yoon JW,Park JH,Cho B,Moon MK,Lim S,Cho YM,Moon S,Kim YJ,Han S,Hwang MY,Cho YS,Lee MS,Jang HC,Kang HM,Park T,Cho NH,Kim K,Kim JI,Park KS

The rs10229583 polymorphism near paired box gene 4 is associated with gestational diabetes mellitus in Chinese women.
The Journal of international medical research46(1)115-121(2018 Jan)
Xu T,Shi Y,Liu J,Liu Y,Zhu A,Xie C,Zhang Y,Chen Y,Ren L

Exome-chip association analysis reveals an Asian-specific missense variant in PAX4 associated with type 2 diabetes in Chinese individuals.
Diabetologia60(1)107-115(2017 01)
Cheung CY,Tang CS,Xu A,Lee CH,Au KW,Xu L,Fong CH,Kwok KH,Chow WS,Woo YC,Yuen MM,Hai JS,Jin YL,Cheung BM,Tan KC,Cherny SS,Zhu F,Zhu T,Thomas GN,Cheng KK,Jiang CQ,Lam TH,Tse HF,Sham PC,Lam KS

PAX4 R192H and P321H polymorphisms in type 2 diabetes and their functional defects.
Journal of human genetics61(11)943-949(2016 Nov)
Sujjitjoon J,Kooptiwut S,Chongjaroen N,Semprasert N,Hanchang W,Chanprasert K,Tangjittipokin W,Yenchitsomanus PT,Plengvidhya N

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PAX4 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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