PAK2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PAK2
Entrez Gene ID	5062
Full Name	p21 (RAC1) activated kinase 2
Synonyms	PAK65,PAKgamma
General protein information	Preferred Names p21 (RAC1) activated kinase 2 Names serine/threonine-protein kinase PAK 2 PAK-2 S6/H4 kinase gamma-PAK p21 (CDKN1A)-activated kinase 2 p21 protein (Cdc42/Rac)-activated kinase 2 p21-activated kinase 2 p58
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q29
Summary	The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008].
Disorder MIM:	605022

mRNA and Protein(s)

mRNA	Protein	Name
XM_011512870.2	XP_011511172.1	serine/threonine-protein kinase PAK 2 isoform X1
NM_002577.4	NP_002568.2	serine/threonine-protein kinase PAK 2
XM_017006501.1	XP_016861990.1	serine/threonine-protein kinase PAK 2 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	PAK2	NP_002568.2
Macaca mulatta (Rhesus monkey)	PAK2	XP_001099936.1
Canis lupus familiaris (dog)	PAK2	XP_849432.1
Bos taurus (cattle)	PAK2	NP_001193656.1
Gallus gallus (chicken)	PAK2	XP_004937052.1
Danio rerio (zebrafish)	pak2b	NP_001020627.1
Neurospora crassa	NCU03894	XP_957533.1
Mus musculus (house mouse)	Pak2	NP_796300.1
Xenopus tropicalis (tropical clawed frog)	pak2	XP_002935145.1
Magnaporthe oryzae (rice blast fungus)	MGG_12821	XP_003717065.1
Pan troglodytes (chimpanzee)	PAK2	XP_516976.3
Danio rerio (zebrafish)	pak2a	NP_001002717.1
Rattus norvegicus (Norway rat)	LOC100910732	XP_003751114.1

Gene Ontology
Bibliography

Related articles in PubMed

Overexpression of p21-activated kinase 2 is correlated with high-grade oral squamous cell carcinomas.
Xiao Y, Deng WW, Yang LL, Li H, Yu GT, Zhang WF, Sun ZJ
Future oncology (London, England)14(11)1091-1100(2018 May)

Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein.
Cheng TY, Yang YC, Wang HP, Tien YW, Shun CT, Huang HY, Hsiao M, Hua KT
Oncogene37(13)1730-1742(2018 03)

MicroRNA miR-4779 suppresses tumor growth by inducing apoptosis and cell cycle arrest through direct targeting of PAK2 and CCND3.
Koo KH, Kwon H
Cell death & disease9(2)77(2018 01)

Human cytomegalovirus miR-US4-5p promotes apoptosis via downregulation of p21-activated kinase 2 in cultured cells.
Shao Y, Qi Y, Huang Y, Liu Z, Ma Y, Guo X, Jiang S, Sun Z, Ruan Q
Molecular medicine reports16(4)4171-4178(2017 Oct)

Expansion of BCR/ABL1
Edlinger L, Berger-Becvar A, Menzl I, Hoermann G, Greiner G, Grundschober E, Bago-Horvath Z, Al-Zoughbi W, Hoefler G, Brostjan C, Gille L, Moriggl R, Spittler A, Sexl V, Hoelbl-Kovacic A
British journal of haematology179(2)229-241(2017 10)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PAK2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PAK2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18323	NM_002577.4 Latest version!	Homo sapiens p21 (RAC1) activated kinase 2 (PAK2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OHu18323	XM_017006501.1 Latest version!	Homo sapiens p21 (RAC1) activated kinase 2 (PAK2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OHu18323	XM_011512870.2 Latest version!	Homo sapiens p21 (RAC1) activated kinase 2 (PAK2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PAK2 ( NM_002577.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002568.2 Homo sapiens p21 (RAC1) activated kinase 2 (PAK2), mRNA.

Price & Availability↑

CloneID	OHu18323
Clone ID Related Accession (Same CDS sequence)	XM_011512870.2 , NM_002577.4 , XM_017006501.1
Accession Version	NM_002577.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1575bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1564761600000
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase PAK 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB164364.1, AK291339.1, BC069613.1 and AC127904.8. This sequence is a reference standard in the RefSeqGene project. On Jun 21, 2008 this sequence version replaced NM_002577.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.141172.1, SRR1660803.20636.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000327134.7/ ENSP00000314067.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTGATA ACGGAGAACT GGAAGATAAG CCTCCAGCAC CTCCTGTGCG AATGAGCAGC 
ACCATCTTTA GCACTGGAGG CAAAGACCCT TTGTCAGCCA ATCACAGTTT GAAACCTTTG 
CCCTCTGTTC CAGAAGAGAA AAAGCCCAGG CATAAAATCA TCTCCATATT CTCAGGCACA 
GAGAAAGGAA GTAAAAAGAA AGAAAAGGAA CGGCCAGAAA TTTCTCCTCC ATCTGATTTT 
GAGCACACCA TCCATGTTGG CTTTGATGCT GTTACTGGAG AATTCACTGG CATGCCAGAA 
CAGTGGGCTC GATTACTACA GACCTCCAAT ATCACCAAAC TAGAGCAAAA GAAGAATCCT 
CAGGCTGTGC TGGATGTCCT AAAGTTCTAC GACTCCAACA CAGTGAAGCA GAAATATCTG 
AGCTTTACTC CTCCTGAGAA AGATGGCTTT CCTTCTGGAA CACCAGCACT GAATGCCAAG 
GGAACAGAAG CACCCGCAGT AGTGACAGAG GAGGAGGATG ATGATGAAGA GACTGCTCCT 
CCCGTTATTG CCCCGCGACC GGATCATACG AAATCAATTT ACACACGGTC TGTAATTGAC 
CCTGTTCCTG CACCAGTTGG TGATTCACAT GTTGATGGTG CTGCCAAGTC TTTAGACAAA 
CAGAAAAAGA AGACTAAGAT GACAGATGAA GAGATTATGG AGAAATTAAG AACTATCGTG 
AGCATAGGTG ACCCTAAGAA AAAATATACA AGATATGAAA AAATTGGACA AGGGGCTTCT 
GGTACAGTTT TCACTGCTAC TGACGTTGCA CTGGGACAGG AGGTTGCTAT CAAACAAATT 
AATTTACAGA AACAGCCAAA GAAGGAACTG ATCATTAACG AGATTCTGGT GATGAAAGAA 
TTGAAAAATC CCAACATCGT TAACTTTTTG GACAGTTACC TGGTAGGAGA TGAATTGTTT 
GTGGTCATGG AATACCTTGC TGGGGGGTCA CTCACTGATG TGGTAACAGA AACGTGCATG 
GATGAAGCAC AGATTGCTGC TGTATGCAGA GAGTGTTTAC AGGCATTGGA GTTTTTACAT 
GCTAATCAAG TGATCCACAG AGACATCAAA AGTGACAATG TACTTTTGGG AATGGAAGGA 
TCTGTTAAGC TCACTGACTT TGGTTTCTGT GCCCAGATCA CCCCTGAGCA GAGCAAACGC 
AGTACCATGG TCGGAACGCC ATACTGGATG GCACCAGAGG TGGTTACACG GAAAGCTTAT 
GGCCCTAAAG TCGACATATG GTCTCTGGGT ATCATGGCTA TTGAGATGGT AGAAGGAGAG 
CCTCCATACC TCAATGAAAA TCCCTTGAGG GCCTTGTACC TAATAGCAAC TAATGGAACC 
CCAGAACTTC AGAATCCAGA GAAACTTTCC CCAATATTTC GGGATTTCTT AAATCGATGT 
TTGGAAATGG ATGTGGAAAA AAGGGGTTCA GCCAAAGAAT TATTACAGCA TCCTTTCCTG 
AAACTGGCCA AACCGTTATC TAGCTTGACA CCACTGATCA TGGCAGCTAA AGAAGCAATG 
AAGAGTAACC GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002568.2
CDS	323..1897
Translation	MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPALNAKGTEAPAVVTEEEDDDEETAPPVIAPRPDHTKSIYTRSVIDPVPAPVGDSHVDGAAKSLDKQKKKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLIMAAKEAMKSNR

Target ORF information:

RefSeq Version	NM_002577.4
Organism	Homo sapiens(human)
Definition	Homo sapiens p21 (RAC1) activated kinase 2 (PAK2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002577.4

ORF Insert Sequence:

ATGTCTGATA ACGGAGAACT GGAAGATAAG CCTCCAGCAC CTCCTGTGCG AATGAGCAGC 
ACCATCTTTA GCACTGGAGG CAAAGACCCT TTGTCAGCCA ATCACAGTTT GAAACCTTTG 
CCCTCTGTTC CAGAAGAGAA AAAGCCCAGG CATAAAATCA TCTCCATATT CTCAGGCACA 
GAGAAAGGAA GTAAAAAGAA AGAAAAGGAA CGGCCAGAAA TTTCTCCTCC ATCTGATTTT 
GAGCACACCA TCCATGTTGG CTTTGATGCT GTTACTGGAG AATTCACTGG CATGCCAGAA 
CAGTGGGCTC GATTACTACA GACCTCCAAT ATCACCAAAC TAGAGCAAAA GAAGAATCCT 
CAGGCTGTGC TGGATGTCCT AAAGTTCTAC GACTCCAACA CAGTGAAGCA GAAATATCTG 
AGCTTTACTC CTCCTGAGAA AGATGGCTTT CCTTCTGGAA CACCAGCACT GAATGCCAAG 
GGAACAGAAG CACCCGCAGT AGTGACAGAG GAGGAGGATG ATGATGAAGA GACTGCTCCT 
CCCGTTATTG CCCCGCGACC GGATCATACG AAATCAATTT ACACACGGTC TGTAATTGAC 
CCTGTTCCTG CACCAGTTGG TGATTCACAT GTTGATGGTG CTGCCAAGTC TTTAGACAAA 
CAGAAAAAGA AGACTAAGAT GACAGATGAA GAGATTATGG AGAAATTAAG AACTATCGTG 
AGCATAGGTG ACCCTAAGAA AAAATATACA AGATATGAAA AAATTGGACA AGGGGCTTCT 
GGTACAGTTT TCACTGCTAC TGACGTTGCA CTGGGACAGG AGGTTGCTAT CAAACAAATT 
AATTTACAGA AACAGCCAAA GAAGGAACTG ATCATTAACG AGATTCTGGT GATGAAAGAA 
TTGAAAAATC CCAACATCGT TAACTTTTTG GACAGTTACC TGGTAGGAGA TGAATTGTTT 
GTGGTCATGG AATACCTTGC TGGGGGGTCA CTCACTGATG TGGTAACAGA AACGTGCATG 
GATGAAGCAC AGATTGCTGC TGTATGCAGA GAGTGTTTAC AGGCATTGGA GTTTTTACAT 
GCTAATCAAG TGATCCACAG AGACATCAAA AGTGACAATG TACTTTTGGG AATGGAAGGA 
TCTGTTAAGC TCACTGACTT TGGTTTCTGT GCCCAGATCA CCCCTGAGCA GAGCAAACGC 
AGTACCATGG TCGGAACGCC ATACTGGATG GCACCAGAGG TGGTTACACG GAAAGCTTAT 
GGCCCTAAAG TCGACATATG GTCTCTGGGT ATCATGGCTA TTGAGATGGT AGAAGGAGAG 
CCTCCATACC TCAATGAAAA TCCCTTGAGG GCCTTGTACC TAATAGCAAC TAATGGAACC 
CCAGAACTTC AGAATCCAGA GAAACTTTCC CCAATATTTC GGGATTTCTT AAATCGATGT 
TTGGAAATGG ATGTGGAAAA AAGGGGTTCA GCCAAAGAAT TATTACAGCA TCCTTTCCTG 
AAACTGGCCA AACCGTTATC TAGCTTGACA CCACTGATCA TGGCAGCTAA AGAAGCAATG 
AAGAGTAACC GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PAK2 ( XM_011512870.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011511172.1 Homo sapiens p21 (RAC1) activated kinase 2 (PAK2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu18323
Clone ID Related Accession (Same CDS sequence)	XM_011512870.2 , NM_002577.4 , XM_017006501.1
Accession Version	XM_011512870.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1575bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase PAK 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011512870.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTGATA ACGGAGAACT GGAAGATAAG CCTCCAGCAC CTCCTGTGCG AATGAGCAGC 
ACCATCTTTA GCACTGGAGG CAAAGACCCT TTGTCAGCCA ATCACAGTTT GAAACCTTTG 
CCCTCTGTTC CAGAAGAGAA AAAGCCCAGG CATAAAATCA TCTCCATATT CTCAGGCACA 
GAGAAAGGAA GTAAAAAGAA AGAAAAGGAA CGGCCAGAAA TTTCTCCTCC ATCTGATTTT 
GAGCACACCA TCCATGTTGG CTTTGATGCT GTTACTGGAG AATTCACTGG CATGCCAGAA 
CAGTGGGCTC GATTACTACA GACCTCCAAT ATCACCAAAC TAGAGCAAAA GAAGAATCCT 
CAGGCTGTGC TGGATGTCCT AAAGTTCTAC GACTCCAACA CAGTGAAGCA GAAATATCTG 
AGCTTTACTC CTCCTGAGAA AGATGGCTTT CCTTCTGGAA CACCAGCACT GAATGCCAAG 
GGAACAGAAG CACCCGCAGT AGTGACAGAG GAGGAGGATG ATGATGAAGA GACTGCTCCT 
CCCGTTATTG CCCCGCGACC GGATCATACG AAATCAATTT ACACACGGTC TGTAATTGAC 
CCTGTTCCTG CACCAGTTGG TGATTCACAT GTTGATGGTG CTGCCAAGTC TTTAGACAAA 
CAGAAAAAGA AGACTAAGAT GACAGATGAA GAGATTATGG AGAAATTAAG AACTATCGTG 
AGCATAGGTG ACCCTAAGAA AAAATATACA AGATATGAAA AAATTGGACA AGGGGCTTCT 
GGTACAGTTT TCACTGCTAC TGACGTTGCA CTGGGACAGG AGGTTGCTAT CAAACAAATT 
AATTTACAGA AACAGCCAAA GAAGGAACTG ATCATTAACG AGATTCTGGT GATGAAAGAA 
TTGAAAAATC CCAACATCGT TAACTTTTTG GACAGTTACC TGGTAGGAGA TGAATTGTTT 
GTGGTCATGG AATACCTTGC TGGGGGGTCA CTCACTGATG TGGTAACAGA AACGTGCATG 
GATGAAGCAC AGATTGCTGC TGTATGCAGA GAGTGTTTAC AGGCATTGGA GTTTTTACAT 
GCTAATCAAG TGATCCACAG AGACATCAAA AGTGACAATG TACTTTTGGG AATGGAAGGA 
TCTGTTAAGC TCACTGACTT TGGTTTCTGT GCCCAGATCA CCCCTGAGCA GAGCAAACGC 
AGTACCATGG TCGGAACGCC ATACTGGATG GCACCAGAGG TGGTTACACG GAAAGCTTAT 
GGCCCTAAAG TCGACATATG GTCTCTGGGT ATCATGGCTA TTGAGATGGT AGAAGGAGAG 
CCTCCATACC TCAATGAAAA TCCCTTGAGG GCCTTGTACC TAATAGCAAC TAATGGAACC 
CCAGAACTTC AGAATCCAGA GAAACTTTCC CCAATATTTC GGGATTTCTT AAATCGATGT 
TTGGAAATGG ATGTGGAAAA AAGGGGTTCA GCCAAAGAAT TATTACAGCA TCCTTTCCTG 
AAACTGGCCA AACCGTTATC TAGCTTGACA CCACTGATCA TGGCAGCTAA AGAAGCAATG 
AAGAGTAACC GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011511172.1
CDS	46..1620
Translation	MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPALNAKGTEAPAVVTEEEDDDEETAPPVIAPRPDHTKSIYTRSVIDPVPAPVGDSHVDGAAKSLDKQKKKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLIMAAKEAMKSNR

Target ORF information:

RefSeq Version	XM_011512870.2
Organism	Homo sapiens(human)
Definition	Homo sapiens p21 (RAC1) activated kinase 2 (PAK2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011512870.2

ORF Insert Sequence:

ATGTCTGATA ACGGAGAACT GGAAGATAAG CCTCCAGCAC CTCCTGTGCG AATGAGCAGC 
ACCATCTTTA GCACTGGAGG CAAAGACCCT TTGTCAGCCA ATCACAGTTT GAAACCTTTG 
CCCTCTGTTC CAGAAGAGAA AAAGCCCAGG CATAAAATCA TCTCCATATT CTCAGGCACA 
GAGAAAGGAA GTAAAAAGAA AGAAAAGGAA CGGCCAGAAA TTTCTCCTCC ATCTGATTTT 
GAGCACACCA TCCATGTTGG CTTTGATGCT GTTACTGGAG AATTCACTGG CATGCCAGAA 
CAGTGGGCTC GATTACTACA GACCTCCAAT ATCACCAAAC TAGAGCAAAA GAAGAATCCT 
CAGGCTGTGC TGGATGTCCT AAAGTTCTAC GACTCCAACA CAGTGAAGCA GAAATATCTG 
AGCTTTACTC CTCCTGAGAA AGATGGCTTT CCTTCTGGAA CACCAGCACT GAATGCCAAG 
GGAACAGAAG CACCCGCAGT AGTGACAGAG GAGGAGGATG ATGATGAAGA GACTGCTCCT 
CCCGTTATTG CCCCGCGACC GGATCATACG AAATCAATTT ACACACGGTC TGTAATTGAC 
CCTGTTCCTG CACCAGTTGG TGATTCACAT GTTGATGGTG CTGCCAAGTC TTTAGACAAA 
CAGAAAAAGA AGACTAAGAT GACAGATGAA GAGATTATGG AGAAATTAAG AACTATCGTG 
AGCATAGGTG ACCCTAAGAA AAAATATACA AGATATGAAA AAATTGGACA AGGGGCTTCT 
GGTACAGTTT TCACTGCTAC TGACGTTGCA CTGGGACAGG AGGTTGCTAT CAAACAAATT 
AATTTACAGA AACAGCCAAA GAAGGAACTG ATCATTAACG AGATTCTGGT GATGAAAGAA 
TTGAAAAATC CCAACATCGT TAACTTTTTG GACAGTTACC TGGTAGGAGA TGAATTGTTT 
GTGGTCATGG AATACCTTGC TGGGGGGTCA CTCACTGATG TGGTAACAGA AACGTGCATG 
GATGAAGCAC AGATTGCTGC TGTATGCAGA GAGTGTTTAC AGGCATTGGA GTTTTTACAT 
GCTAATCAAG TGATCCACAG AGACATCAAA AGTGACAATG TACTTTTGGG AATGGAAGGA 
TCTGTTAAGC TCACTGACTT TGGTTTCTGT GCCCAGATCA CCCCTGAGCA GAGCAAACGC 
AGTACCATGG TCGGAACGCC ATACTGGATG GCACCAGAGG TGGTTACACG GAAAGCTTAT 
GGCCCTAAAG TCGACATATG GTCTCTGGGT ATCATGGCTA TTGAGATGGT AGAAGGAGAG 
CCTCCATACC TCAATGAAAA TCCCTTGAGG GCCTTGTACC TAATAGCAAC TAATGGAACC 
CCAGAACTTC AGAATCCAGA GAAACTTTCC CCAATATTTC GGGATTTCTT AAATCGATGT 
TTGGAAATGG ATGTGGAAAA AAGGGGTTCA GCCAAAGAAT TATTACAGCA TCCTTTCCTG 
AAACTGGCCA AACCGTTATC TAGCTTGACA CCACTGATCA TGGCAGCTAA AGAAGCAATG 
AAGAGTAACC GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PAK2 ( XM_017006501.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016861990.1 Homo sapiens p21 (RAC1) activated kinase 2 (PAK2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu18323
Clone ID Related Accession (Same CDS sequence)	XM_011512870.2 , NM_002577.4 , XM_017006501.1
Accession Version	XM_017006501.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1575bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase PAK 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTGATA ACGGAGAACT GGAAGATAAG CCTCCAGCAC CTCCTGTGCG AATGAGCAGC 
ACCATCTTTA GCACTGGAGG CAAAGACCCT TTGTCAGCCA ATCACAGTTT GAAACCTTTG 
CCCTCTGTTC CAGAAGAGAA AAAGCCCAGG CATAAAATCA TCTCCATATT CTCAGGCACA 
GAGAAAGGAA GTAAAAAGAA AGAAAAGGAA CGGCCAGAAA TTTCTCCTCC ATCTGATTTT 
GAGCACACCA TCCATGTTGG CTTTGATGCT GTTACTGGAG AATTCACTGG CATGCCAGAA 
CAGTGGGCTC GATTACTACA GACCTCCAAT ATCACCAAAC TAGAGCAAAA GAAGAATCCT 
CAGGCTGTGC TGGATGTCCT AAAGTTCTAC GACTCCAACA CAGTGAAGCA GAAATATCTG 
AGCTTTACTC CTCCTGAGAA AGATGGCTTT CCTTCTGGAA CACCAGCACT GAATGCCAAG 
GGAACAGAAG CACCCGCAGT AGTGACAGAG GAGGAGGATG ATGATGAAGA GACTGCTCCT 
CCCGTTATTG CCCCGCGACC GGATCATACG AAATCAATTT ACACACGGTC TGTAATTGAC 
CCTGTTCCTG CACCAGTTGG TGATTCACAT GTTGATGGTG CTGCCAAGTC TTTAGACAAA 
CAGAAAAAGA AGACTAAGAT GACAGATGAA GAGATTATGG AGAAATTAAG AACTATCGTG 
AGCATAGGTG ACCCTAAGAA AAAATATACA AGATATGAAA AAATTGGACA AGGGGCTTCT 
GGTACAGTTT TCACTGCTAC TGACGTTGCA CTGGGACAGG AGGTTGCTAT CAAACAAATT 
AATTTACAGA AACAGCCAAA GAAGGAACTG ATCATTAACG AGATTCTGGT GATGAAAGAA 
TTGAAAAATC CCAACATCGT TAACTTTTTG GACAGTTACC TGGTAGGAGA TGAATTGTTT 
GTGGTCATGG AATACCTTGC TGGGGGGTCA CTCACTGATG TGGTAACAGA AACGTGCATG 
GATGAAGCAC AGATTGCTGC TGTATGCAGA GAGTGTTTAC AGGCATTGGA GTTTTTACAT 
GCTAATCAAG TGATCCACAG AGACATCAAA AGTGACAATG TACTTTTGGG AATGGAAGGA 
TCTGTTAAGC TCACTGACTT TGGTTTCTGT GCCCAGATCA CCCCTGAGCA GAGCAAACGC 
AGTACCATGG TCGGAACGCC ATACTGGATG GCACCAGAGG TGGTTACACG GAAAGCTTAT 
GGCCCTAAAG TCGACATATG GTCTCTGGGT ATCATGGCTA TTGAGATGGT AGAAGGAGAG 
CCTCCATACC TCAATGAAAA TCCCTTGAGG GCCTTGTACC TAATAGCAAC TAATGGAACC 
CCAGAACTTC AGAATCCAGA GAAACTTTCC CCAATATTTC GGGATTTCTT AAATCGATGT 
TTGGAAATGG ATGTGGAAAA AAGGGGTTCA GCCAAAGAAT TATTACAGCA TCCTTTCCTG 
AAACTGGCCA AACCGTTATC TAGCTTGACA CCACTGATCA TGGCAGCTAA AGAAGCAATG 
AAGAGTAACC GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016861990.1
CDS	510..2084
Translation	MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPALNAKGTEAPAVVTEEEDDDEETAPPVIAPRPDHTKSIYTRSVIDPVPAPVGDSHVDGAAKSLDKQKKKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLIMAAKEAMKSNR

Target ORF information:

RefSeq Version	XM_017006501.1
Organism	Homo sapiens(human)
Definition	Homo sapiens p21 (RAC1) activated kinase 2 (PAK2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017006501.1

ORF Insert Sequence:

ATGTCTGATA ACGGAGAACT GGAAGATAAG CCTCCAGCAC CTCCTGTGCG AATGAGCAGC 
ACCATCTTTA GCACTGGAGG CAAAGACCCT TTGTCAGCCA ATCACAGTTT GAAACCTTTG 
CCCTCTGTTC CAGAAGAGAA AAAGCCCAGG CATAAAATCA TCTCCATATT CTCAGGCACA 
GAGAAAGGAA GTAAAAAGAA AGAAAAGGAA CGGCCAGAAA TTTCTCCTCC ATCTGATTTT 
GAGCACACCA TCCATGTTGG CTTTGATGCT GTTACTGGAG AATTCACTGG CATGCCAGAA 
CAGTGGGCTC GATTACTACA GACCTCCAAT ATCACCAAAC TAGAGCAAAA GAAGAATCCT 
CAGGCTGTGC TGGATGTCCT AAAGTTCTAC GACTCCAACA CAGTGAAGCA GAAATATCTG 
AGCTTTACTC CTCCTGAGAA AGATGGCTTT CCTTCTGGAA CACCAGCACT GAATGCCAAG 
GGAACAGAAG CACCCGCAGT AGTGACAGAG GAGGAGGATG ATGATGAAGA GACTGCTCCT 
CCCGTTATTG CCCCGCGACC GGATCATACG AAATCAATTT ACACACGGTC TGTAATTGAC 
CCTGTTCCTG CACCAGTTGG TGATTCACAT GTTGATGGTG CTGCCAAGTC TTTAGACAAA 
CAGAAAAAGA AGACTAAGAT GACAGATGAA GAGATTATGG AGAAATTAAG AACTATCGTG 
AGCATAGGTG ACCCTAAGAA AAAATATACA AGATATGAAA AAATTGGACA AGGGGCTTCT 
GGTACAGTTT TCACTGCTAC TGACGTTGCA CTGGGACAGG AGGTTGCTAT CAAACAAATT 
AATTTACAGA AACAGCCAAA GAAGGAACTG ATCATTAACG AGATTCTGGT GATGAAAGAA 
TTGAAAAATC CCAACATCGT TAACTTTTTG GACAGTTACC TGGTAGGAGA TGAATTGTTT 
GTGGTCATGG AATACCTTGC TGGGGGGTCA CTCACTGATG TGGTAACAGA AACGTGCATG 
GATGAAGCAC AGATTGCTGC TGTATGCAGA GAGTGTTTAC AGGCATTGGA GTTTTTACAT 
GCTAATCAAG TGATCCACAG AGACATCAAA AGTGACAATG TACTTTTGGG AATGGAAGGA 
TCTGTTAAGC TCACTGACTT TGGTTTCTGT GCCCAGATCA CCCCTGAGCA GAGCAAACGC 
AGTACCATGG TCGGAACGCC ATACTGGATG GCACCAGAGG TGGTTACACG GAAAGCTTAT 
GGCCCTAAAG TCGACATATG GTCTCTGGGT ATCATGGCTA TTGAGATGGT AGAAGGAGAG 
CCTCCATACC TCAATGAAAA TCCCTTGAGG GCCTTGTACC TAATAGCAAC TAATGGAACC 
CCAGAACTTC AGAATCCAGA GAAACTTTCC CCAATATTTC GGGATTTCTT AAATCGATGT 
TTGGAAATGG ATGTGGAAAA AAGGGGTTCA GCCAAAGAAT TATTACAGCA TCCTTTCCTG 
AAACTGGCCA AACCGTTATC TAGCTTGACA CCACTGATCA TGGCAGCTAA AGAAGCAATG 
AAGAGTAACC GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Overexpression of p21-activated kinase 2 is correlated with high-grade oral squamous cell carcinomas.
Future oncology (London, England)14(11)1091-1100(2018 May)
Xiao Y,Deng WW,Yang LL,Li H,Yu GT,Zhang WF,Sun ZJ

Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein.
Oncogene37(13)1730-1742(2018 03)
Cheng TY,Yang YC,Wang HP,Tien YW,Shun CT,Huang HY,Hsiao M,Hua KT

MicroRNA miR-4779 suppresses tumor growth by inducing apoptosis and cell cycle arrest through direct targeting of PAK2 and CCND3.
Cell death & disease9(2)77(2018 01)
Koo KH,Kwon H

Human cytomegalovirus miR-US4-5p promotes apoptosis via downregulation of p21-activated kinase 2 in cultured cells.
Molecular medicine reports16(4)4171-4178(2017 Oct)
Shao Y,Qi Y,Huang Y,Liu Z,Ma Y,Guo X,Jiang S,Sun Z,Ruan Q

Expansion of BCR/ABL1
British journal of haematology179(2)229-241(2017 10)
Edlinger L,Berger-Becvar A,Menzl I,Hoermann G,Greiner G,Grundschober E,Bago-Horvath Z,Al-Zoughbi W,Hoefler G,Brostjan C,Gille L,Moriggl R,Spittler A,Sexl V,Hoelbl-Kovacic A

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PAK2 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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