ART4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ART4
Entrez Gene ID	420
Full Name	ADP-ribosyltransferase 4 (Dombrock blood group)
Synonyms	ARTC4,CD297,DO,DOK1
General protein information	Preferred Names ADP-ribosyltransferase 4 (Dombrock blood group) Names ecto-ADP-ribosyltransferase 4 ADP-ribosyltransferase 4 (DO blood group) ADP-ribosyltransferase C2 and C3 toxin-like 4 Dombrock blood group carrier molecule NAD(+)--protein-arginine ADP-ribosyltransferase 4 NAD(P)(+)--arginine ADP-ribosyltransferase 4 mono-ADP-ribosyltransferase 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p12.3
Summary	This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known. [provided by RefSeq, Jul 2008].
Disorder MIM:	110600
Disorder Html:	[Blood group, Dombrock], 616060 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_021071.2	NP_066549.2	ecto-ADP-ribosyltransferase 4 precursor
NM_021071.3	NP_066549.2	ecto-ADP-ribosyltransferase 4 isoform 1 precursor
NM_021071.4	NP_066549.2	ecto-ADP-ribosyltransferase 4 isoform 1 precursor
NM_001354646.1	NP_001341575.1	ecto-ADP-ribosyltransferase 4 isoform 2 precursor
NM_001354646.2	NP_001341575.1	ecto-ADP-ribosyltransferase 4 isoform 2 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ART4	NP_001009134.1
Rattus norvegicus (Norway rat)	Art4	NP_001166980.1
Danio rerio (zebrafish)	LOC101882582	XP_005164376.1
Danio rerio (zebrafish)	LOC100334237	XP_002664212.2
Danio rerio (zebrafish)	LOC100537504	XP_003198089.2
Danio rerio (zebrafish)	LOC100535828	XP_003198105.1
Bos taurus (cattle)	ART4	XP_002687818.2
Danio rerio (zebrafish)	LOC795797	XP_001332525.3
Danio rerio (zebrafish)	LOC101884769	XP_005163748.1
Homo sapiens (human)	ART4	NP_066549.2
Canis lupus familiaris (dog)	ART4	XP_543795.1
Gallus gallus (chicken)	ART4	NP_001135727.1
Danio rerio (zebrafish)	art4	XP_683240.1
Danio rerio (zebrafish)	LOC100537553	XP_003198090.2
Danio rerio (zebrafish)	LOC100535865	XP_005163787.1
Mus musculus (house mouse)	Art4	NP_080915.1
Danio rerio (zebrafish)	LOC101883017	XP_005164379.1
Danio rerio (zebrafish)	LOC100329579	XP_002661082.2
Macaca mulatta (Rhesus monkey)	ART4	XP_001090760.1
Danio rerio (zebrafish)	LOC101882480	XP_005168522.1

Gene Ontology
Bibliography

Related articles in PubMed

Sequencing of the ART4 gene in sub-Saharan cohorts reveals ethnic differences and two new DO alleles: DO*B-Ile5Thr and DO*B-Trp266Arg.
Durousseau de Coulgeans C, Chiaroni J, Bailly P, Chapel-Fernandes S
Transfusion55(10)2376-83(2015 Oct)

A novel DO null allele with a c.268C>T (p.Gln90Stop) mutation in Japanese.
Onodera T, Tsuneyama H, Ogasawara K, Isa K, Satake M, Tadokoro K, Uchikawa M
Vox sanguinis109(2)191-3(2015 Aug)

The production, serologic evaluation, and epitope mapping of ten murine monoclonal Dombrock antibodies.
Grodecka M, Wasniowska K, Halverson G, Yazdanbakhsh K, Reid ME, Lisowska E
Immunohematology28(4)124-9(2012)

Single PCR multiplex SNaPshot reaction for detection of eleven blood group nucleotide polymorphisms: optimization, validation, and one year of routine clinical use.
Di Cristofaro J, Silvy M, Chiaroni J, Bailly P
The Journal of molecular diagnostics : JMD12(4)453-60(2010 Jul)

The Dombrock blood group system: a review.
Lomas-Francis C, Reid ME
Immunohematology26(2)71-8(2010)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ART4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ART4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu103435	NM_001354646.2 Latest version!	Homo sapiens ADP-ribosyltransferase 4 (Dombrock blood group) (ART4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu18469	NM_021071.4 Latest version!	Homo sapiens ADP-ribosyltransferase 4 (Dombrock blood group) (ART4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$216.30 $309.00
View Old Accession Versions >>
OHu18469	NM_021071.2	Homo sapiens ADP-ribosyltransferase 4 (Dombrock blood group) (ART4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu18469	NM_021071.3	Homo sapiens ADP-ribosyltransferase 4 (Dombrock blood group) (ART4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu103435	NM_001354646.1	Homo sapiens ADP-ribosyltransferase 4 (Dombrock blood group) (ART4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ART4 ( NM_021071.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_066549.2 Homo sapiens ADP-ribosyltransferase 4 (Dombrock blood group) (ART4), mRNA.

Price & Availability↑

CloneID	OHu18469
Clone ID Related Accession (Same CDS sequence)	NM_021071.2 , NM_021071.3 , NM_021071.4
Accession Version	NM_021071.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1475596800000
Organism	Homo sapiens(Human)
Product	ecto-ADP-ribosyltransferase 4 precursor
Comment	REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CR746266.1, AF290204.1 and BX096478.1. This sequence is a reference standard in the RefSeqGene project. On Mar 25, 2005 this sequence version replaced NM_021071.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK291662.1, AY829434.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2142363 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGTCCAT TGATCAACAG ATGCAAGAAG ATTCTTCTCC CAACTACTGT ACCTCCTGCA 
ACGATGAGAA TCTGGCTCCT TGGAGGCCTG CTGCCATTCC TGCTGCTCCT CTCTGGCCTG 
CAGAGACCCA CAGAGGGTTC TGAGGTTGCA ATTAAAATCG ACTTCGACTT CGCACCAGGT 
TCTTTTGATG ATCAGTACCA AGGCTGTAGC AAACAGGTTA TGGAGAAACT AACTCAAGGG 
GATTATTTCA CAAAAGACAT AGAAGCCCAG AAGAATTATT TTAGGATGTG GCAAAAAGCC 
CACTTAGCCT GGCTTAACCA AGGAAAAGTT CTACCCCAGA ACATGACTAC CACACACGCT 
GTGGCTATTT TGTTTTATAC ATTGAACAGC AATGTTCATT CTGACTTTAC TAGAGCCATG 
GCCTCTGTTG CCAGGACTCC ACAGCAGTAT GAACGTTCAT TCCACTTCAA ATATTTACAC 
TACTACCTCA CCTCAGCAAT CCAGCTGCTG AGGAAAGACA GCATCATGGA GAATGGCACT 
CTGTGCTATG AGGTGCATTA TAGGACGAAG GATGTCCACT TTAATGCCTA CACAGGGGCC 
ACCATTCGAT TTGGCCAATT CCTCTCCACA TCCCTCCTGA AAGAAGAGGC ACAGGAGTTT 
GGGAACCAGA CACTATTTAC CATATTCACC TGCCTGGGTG CACCTGTACA GTACTTCTCC 
CTCAAGAAGG AAGTCTTGAT CCCTCCCTAT GAGCTGTTTA AAGTTATAAA TATGAGCTAC 
CACCCAAGAG GAGACTGGTT GCAGTTGAGG TCAACTGGGA ACCTGAGCAC ATATAACTGT 
CAGCTGCTAA AAGCTTCCAG CAAGAAATGC ATCCCTGATC CTATAGCTAT TGCATCTCTC 
TCCTTTTTGA CCAGTGTCAT CATCTTTTCC AAAAGCAGAG TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066549.2
CDS	367..1311
Translation	MGPLINRCKKILLPTTVPPATMRIWLLGGLLPFLLLLSGLQRPTEGSEVAIKIDFDFAPGSFDDQYQGCSKQVMEKLTQGDYFTKDIEAQKNYFRMWQKAHLAWLNQGKVLPQNMTTTHAVAILFYTLNSNVHSDFTRAMASVARTPQQYERSFHFKYLHYYLTSAIQLLRKDSIMENGTLCYEVHYRTKDVHFNAYTGATIRFGQFLSTSLLKEEAQEFGNQTLFTIFTCLGAPVQYFSLKKEVLIPPYELFKVINMSYHPRGDWLQLRSTGNLSTYNCQLLKASSKKCIPDPIAIASLSFLTSVIIFSKSRV

Target ORF information:

RefSeq Version	NM_021071.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens ADP-ribosyltransferase 4 (Dombrock blood group) (ART4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021071.2

ORF Insert Sequence:

ATGGGTCCAT TGATCAACAG ATGCAAGAAG ATTCTTCTCC CAACTACTGT ACCTCCTGCA 
ACGATGAGAA TCTGGCTCCT TGGAGGCCTG CTGCCATTCC TGCTGCTCCT CTCTGGCCTG 
CAGAGACCCA CAGAGGGTTC TGAGGTTGCA ATTAAAATCG ACTTCGACTT CGCACCAGGT 
TCTTTTGATG ATCAGTACCA AGGCTGTAGC AAACAGGTTA TGGAGAAACT AACTCAAGGG 
GATTATTTCA CAAAAGACAT AGAAGCCCAG AAGAATTATT TTAGGATGTG GCAAAAAGCC 
CACTTAGCCT GGCTTAACCA AGGAAAAGTT CTACCCCAGA ACATGACTAC CACACACGCT 
GTGGCTATTT TGTTTTATAC ATTGAACAGC AATGTTCATT CTGACTTTAC TAGAGCCATG 
GCCTCTGTTG CCAGGACTCC ACAGCAGTAT GAACGTTCAT TCCACTTCAA ATATTTACAC 
TACTACCTCA CCTCAGCAAT CCAGCTGCTG AGGAAAGACA GCATCATGGA GAATGGCACT 
CTGTGCTATG AGGTGCATTA TAGGACGAAG GATGTCCACT TTAATGCCTA CACAGGGGCC 
ACCATTCGAT TTGGCCAATT CCTCTCCACA TCCCTCCTGA AAGAAGAGGC ACAGGAGTTT 
GGGAACCAGA CACTATTTAC CATATTCACC TGCCTGGGTG CACCTGTACA GTACTTCTCC 
CTCAAGAAGG AAGTCTTGAT CCCTCCCTAT GAGCTGTTTA AAGTTATAAA TATGAGCTAC 
CACCCAAGAG GAGACTGGTT GCAGTTGAGG TCAACTGGGA ACCTGAGCAC ATATAACTGT 
CAGCTGCTAA AAGCTTCCAG CAAGAAATGC ATCCCTGATC CTATAGCTAT TGCATCTCTC 
TCCTTTTTGA CCAGTGTCAT CATCTTTTCC AAAAGCAGAG TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ART4 ( NM_021071.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_066549.2 Homo sapiens ADP-ribosyltransferase 4 (Dombrock blood group) (ART4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18469
Clone ID Related Accession (Same CDS sequence)	NM_021071.2 , NM_021071.3 , NM_021071.4
Accession Version	NM_021071.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1504886400000
Organism	Homo sapiens(human)
Product	ecto-ADP-ribosyltransferase 4 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007655.1, CR746266.1, AF290204.1 and BX096478.1. On Aug 17, 2017 this sequence version replaced NM_021071.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK291662.1, AY829434.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2142363 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGTCCAT TGATCAACAG ATGCAAGAAG ATTCTTCTCC CAACTACTGT ACCTCCTGCA 
ACGATGAGAA TCTGGCTCCT TGGAGGCCTG CTGCCATTCC TGCTGCTCCT CTCTGGCCTG 
CAGAGACCCA CAGAGGGTTC TGAGGTTGCA ATTAAAATCG ACTTCGACTT CGCACCAGGT 
TCTTTTGATG ATCAGTACCA AGGCTGTAGC AAACAGGTTA TGGAGAAACT AACTCAAGGG 
GATTATTTCA CAAAAGACAT AGAAGCCCAG AAGAATTATT TTAGGATGTG GCAAAAAGCC 
CACTTAGCCT GGCTTAACCA AGGAAAAGTT CTACCCCAGA ACATGACTAC CACACACGCT 
GTGGCTATTT TGTTTTATAC ATTGAACAGC AATGTTCATT CTGACTTTAC TAGAGCCATG 
GCCTCTGTTG CCAGGACTCC ACAGCAGTAT GAACGTTCAT TCCACTTCAA ATATTTACAC 
TACTACCTCA CCTCAGCAAT CCAGCTGCTG AGGAAAGACA GCATCATGGA GAATGGCACT 
CTGTGCTATG AGGTGCATTA TAGGACGAAG GATGTCCACT TTAATGCCTA CACAGGGGCC 
ACCATTCGAT TTGGCCAATT CCTCTCCACA TCCCTCCTGA AAGAAGAGGC ACAGGAGTTT 
GGGAACCAGA CACTATTTAC CATATTCACC TGCCTGGGTG CACCTGTACA GTACTTCTCC 
CTCAAGAAGG AAGTCTTGAT CCCTCCCTAT GAGCTGTTTA AAGTTATAAA TATGAGCTAC 
CACCCAAGAG GAGACTGGTT GCAGTTGAGG TCAACTGGGA ACCTGAGCAC ATATAACTGT 
CAGCTGCTAA AAGCTTCCAG CAAGAAATGC ATCCCTGATC CTATAGCTAT TGCATCTCTC 
TCCTTTTTGA CCAGTGTCAT CATCTTTTCC AAAAGCAGAG TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066549.2
CDS	421..1365
Translation	MGPLINRCKKILLPTTVPPATMRIWLLGGLLPFLLLLSGLQRPTEGSEVAIKIDFDFAPGSFDDQYQGCSKQVMEKLTQGDYFTKDIEAQKNYFRMWQKAHLAWLNQGKVLPQNMTTTHAVAILFYTLNSNVHSDFTRAMASVARTPQQYERSFHFKYLHYYLTSAIQLLRKDSIMENGTLCYEVHYRTKDVHFNAYTGATIRFGQFLSTSLLKEEAQEFGNQTLFTIFTCLGAPVQYFSLKKEVLIPPYELFKVINMSYHPRGDWLQLRSTGNLSTYNCQLLKASSKKCIPDPIAIASLSFLTSVIIFSKSRV

Target ORF information:

RefSeq Version	NM_021071.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ADP-ribosyltransferase 4 (Dombrock blood group) (ART4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021071.3

ORF Insert Sequence:

ATGGGTCCAT TGATCAACAG ATGCAAGAAG ATTCTTCTCC CAACTACTGT ACCTCCTGCA 
ACGATGAGAA TCTGGCTCCT TGGAGGCCTG CTGCCATTCC TGCTGCTCCT CTCTGGCCTG 
CAGAGACCCA CAGAGGGTTC TGAGGTTGCA ATTAAAATCG ACTTCGACTT CGCACCAGGT 
TCTTTTGATG ATCAGTACCA AGGCTGTAGC AAACAGGTTA TGGAGAAACT AACTCAAGGG 
GATTATTTCA CAAAAGACAT AGAAGCCCAG AAGAATTATT TTAGGATGTG GCAAAAAGCC 
CACTTAGCCT GGCTTAACCA AGGAAAAGTT CTACCCCAGA ACATGACTAC CACACACGCT 
GTGGCTATTT TGTTTTATAC ATTGAACAGC AATGTTCATT CTGACTTTAC TAGAGCCATG 
GCCTCTGTTG CCAGGACTCC ACAGCAGTAT GAACGTTCAT TCCACTTCAA ATATTTACAC 
TACTACCTCA CCTCAGCAAT CCAGCTGCTG AGGAAAGACA GCATCATGGA GAATGGCACT 
CTGTGCTATG AGGTGCATTA TAGGACGAAG GATGTCCACT TTAATGCCTA CACAGGGGCC 
ACCATTCGAT TTGGCCAATT CCTCTCCACA TCCCTCCTGA AAGAAGAGGC ACAGGAGTTT 
GGGAACCAGA CACTATTTAC CATATTCACC TGCCTGGGTG CACCTGTACA GTACTTCTCC 
CTCAAGAAGG AAGTCTTGAT CCCTCCCTAT GAGCTGTTTA AAGTTATAAA TATGAGCTAC 
CACCCAAGAG GAGACTGGTT GCAGTTGAGG TCAACTGGGA ACCTGAGCAC ATATAACTGT 
CAGCTGCTAA AAGCTTCCAG CAAGAAATGC ATCCCTGATC CTATAGCTAT TGCATCTCTC 
TCCTTTTTGA CCAGTGTCAT CATCTTTTCC AAAAGCAGAG TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ART4 ( NM_001354646.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001341575.1 Homo sapiens ADP-ribosyltransferase 4 (Dombrock blood group) (ART4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu103435
Clone ID Related Accession (Same CDS sequence)	NM_001354646.1 , NM_001354646.2
Accession Version	NM_001354646.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1551110400000
Organism	Homo sapiens(human)
Product	ecto-ADP-ribosyltransferase 4 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007655.1, AY829437.1 and AI149009.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP236431.1, AY829437.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGTCCAT TGATCAACAG ATGCAAGAAG ATTCTTCTCC CAACTACTGT ACCTCCTGCA 
ACGATGAGAA TCTGGCTCCT TGGAGGCCTG CTGCCATTCC TGCTGCTCCT CTCTGGCCTG 
CAGAGACCCA CAGAGGGTTC TGAGGTTGCA ATTAAAATCG ACTTCGACTT CGCACCAGGT 
TCTTTTGATG ATCAGTACCA AGGCTGTAGC AAACAGGTTA TGGAGAAACT AACTCAAGGG 
GATTATTTCA CAAAAGACAT AGAAGCCCAG AAGAATTATT TTAGGATGTG GCAAAAAGCC 
CACTTAGCCT GGCTTAACCA AGGAAAAGTT CTACCCCAGA ACATGACTAC CACACACGCT 
GTGGCTATTT TGTTTTATAC ATTGAACAGC AATGTTCATT CTGACTTTAC TAGAGCCATG 
GCCTCTGTTG CCAGGACTCC ACAGCAGTAT GAACGTTCAT TCCACTTCAA ATATTTACAC 
TACTACCTCA CCTCAGCAAT CCAGCTGCTG AGGAAAGACA GCATCATGGA GAATGGCACT 
CTGTGCTATG AGGTGCATTA TAGGACGAAG GATGTCCACT TTAATGCCTA CACAGGGGCC 
ACCATTCGAT TTGGCCAATT CCTCTCCACA TCCCTCCTGA AAGAAGAGGC ACAGGAGTTT 
GGGAACCAGA CACTATTTAC CATATTCACC TGCCTGGGTG CACCTGTACA GTACTTCTCC 
CTCAAGAAGG AAGTCTTGAT CCCTCCCTAT GAGCTGTTTA AAGTTATAAA TATGAGCTAC 
CACCCAAGAG GAGACTGGTT GCAGTTGAGG TCAACTGGGA ACCTGAGCAC ATATAACTGT 
CAGCTGCTAA AAGGTATTCT TTATCTAAAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001341575.1
CDS	421..1293
Translation	MGPLINRCKKILLPTTVPPATMRIWLLGGLLPFLLLLSGLQRPTEGSEVAIKIDFDFAPGSFDDQYQGCSKQVMEKLTQGDYFTKDIEAQKNYFRMWQKAHLAWLNQGKVLPQNMTTTHAVAILFYTLNSNVHSDFTRAMASVARTPQQYERSFHFKYLHYYLTSAIQLLRKDSIMENGTLCYEVHYRTKDVHFNAYTGATIRFGQFLSTSLLKEEAQEFGNQTLFTIFTCLGAPVQYFSLKKEVLIPPYELFKVINMSYHPRGDWLQLRSTGNLSTYNCQLLKGILYLN

Target ORF information:

RefSeq Version	NM_001354646.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ADP-ribosyltransferase 4 (Dombrock blood group) (ART4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001354646.1

ORF Insert Sequence:

ATGGGTCCAT TGATCAACAG ATGCAAGAAG ATTCTTCTCC CAACTACTGT ACCTCCTGCA 
ACGATGAGAA TCTGGCTCCT TGGAGGCCTG CTGCCATTCC TGCTGCTCCT CTCTGGCCTG 
CAGAGACCCA CAGAGGGTTC TGAGGTTGCA ATTAAAATCG ACTTCGACTT CGCACCAGGT 
TCTTTTGATG ATCAGTACCA AGGCTGTAGC AAACAGGTTA TGGAGAAACT AACTCAAGGG 
GATTATTTCA CAAAAGACAT AGAAGCCCAG AAGAATTATT TTAGGATGTG GCAAAAAGCC 
CACTTAGCCT GGCTTAACCA AGGAAAAGTT CTACCCCAGA ACATGACTAC CACACACGCT 
GTGGCTATTT TGTTTTATAC ATTGAACAGC AATGTTCATT CTGACTTTAC TAGAGCCATG 
GCCTCTGTTG CCAGGACTCC ACAGCAGTAT GAACGTTCAT TCCACTTCAA ATATTTACAC 
TACTACCTCA CCTCAGCAAT CCAGCTGCTG AGGAAAGACA GCATCATGGA GAATGGCACT 
CTGTGCTATG AGGTGCATTA TAGGACGAAG GATGTCCACT TTAATGCCTA CACAGGGGCC 
ACCATTCGAT TTGGCCAATT CCTCTCCACA TCCCTCCTGA AAGAAGAGGC ACAGGAGTTT 
GGGAACCAGA CACTATTTAC CATATTCACC TGCCTGGGTG CACCTGTACA GTACTTCTCC 
CTCAAGAAGG AAGTCTTGAT CCCTCCCTAT GAGCTGTTTA AAGTTATAAA TATGAGCTAC 
CACCCAAGAG GAGACTGGTT GCAGTTGAGG TCAACTGGGA ACCTGAGCAC ATATAACTGT 
CAGCTGCTAA AAGGTATTCT TTATCTAAAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ART4 ( NM_001354646.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001341575.1 Homo sapiens ADP-ribosyltransferase 4 (Dombrock blood group) (ART4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu103435
Clone ID Related Accession (Same CDS sequence)	NM_001354646.1 , NM_001354646.2
Accession Version	NM_001354646.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569600000000
Organism	Homo sapiens(human)
Product	ecto-ADP-ribosyltransferase 4 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007655.1, AY829437.1 and AI149009.1. On Jun 1, 2019 this sequence version replaced NM_001354646.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY829437.1, CR746266.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGTCCAT TGATCAACAG ATGCAAGAAG ATTCTTCTCC CAACTACTGT ACCTCCTGCA 
ACGATGAGAA TCTGGCTCCT TGGAGGCCTG CTGCCATTCC TGCTGCTCCT CTCTGGCCTG 
CAGAGACCCA CAGAGGGTTC TGAGGTTGCA ATTAAAATCG ACTTCGACTT CGCACCAGGT 
TCTTTTGATG ATCAGTACCA AGGCTGTAGC AAACAGGTTA TGGAGAAACT AACTCAAGGG 
GATTATTTCA CAAAAGACAT AGAAGCCCAG AAGAATTATT TTAGGATGTG GCAAAAAGCC 
CACTTAGCCT GGCTTAACCA AGGAAAAGTT CTACCCCAGA ACATGACTAC CACACACGCT 
GTGGCTATTT TGTTTTATAC ATTGAACAGC AATGTTCATT CTGACTTTAC TAGAGCCATG 
GCCTCTGTTG CCAGGACTCC ACAGCAGTAT GAACGTTCAT TCCACTTCAA ATATTTACAC 
TACTACCTCA CCTCAGCAAT CCAGCTGCTG AGGAAAGACA GCATCATGGA GAATGGCACT 
CTGTGCTATG AGGTGCATTA TAGGACGAAG GATGTCCACT TTAATGCCTA CACAGGGGCC 
ACCATTCGAT TTGGCCAATT CCTCTCCACA TCCCTCCTGA AAGAAGAGGC ACAGGAGTTT 
GGGAACCAGA CACTATTTAC CATATTCACC TGCCTGGGTG CACCTGTACA GTACTTCTCC 
CTCAAGAAGG AAGTCTTGAT CCCTCCCTAT GAGCTGTTTA AAGTTATAAA TATGAGCTAC 
CACCCAAGAG GAGACTGGTT GCAGTTGAGG TCAACTGGGA ACCTGAGCAC ATATAACTGT 
CAGCTGCTAA AAGGTATTCT TTATCTAAAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001341575.1
CDS	414..1286
Translation	MGPLINRCKKILLPTTVPPATMRIWLLGGLLPFLLLLSGLQRPTEGSEVAIKIDFDFAPGSFDDQYQGCSKQVMEKLTQGDYFTKDIEAQKNYFRMWQKAHLAWLNQGKVLPQNMTTTHAVAILFYTLNSNVHSDFTRAMASVARTPQQYERSFHFKYLHYYLTSAIQLLRKDSIMENGTLCYEVHYRTKDVHFNAYTGATIRFGQFLSTSLLKEEAQEFGNQTLFTIFTCLGAPVQYFSLKKEVLIPPYELFKVINMSYHPRGDWLQLRSTGNLSTYNCQLLKGILYLN

Target ORF information:

RefSeq Version	NM_001354646.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ADP-ribosyltransferase 4 (Dombrock blood group) (ART4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001354646.2

ORF Insert Sequence:

ATGGGTCCAT TGATCAACAG ATGCAAGAAG ATTCTTCTCC CAACTACTGT ACCTCCTGCA 
ACGATGAGAA TCTGGCTCCT TGGAGGCCTG CTGCCATTCC TGCTGCTCCT CTCTGGCCTG 
CAGAGACCCA CAGAGGGTTC TGAGGTTGCA ATTAAAATCG ACTTCGACTT CGCACCAGGT 
TCTTTTGATG ATCAGTACCA AGGCTGTAGC AAACAGGTTA TGGAGAAACT AACTCAAGGG 
GATTATTTCA CAAAAGACAT AGAAGCCCAG AAGAATTATT TTAGGATGTG GCAAAAAGCC 
CACTTAGCCT GGCTTAACCA AGGAAAAGTT CTACCCCAGA ACATGACTAC CACACACGCT 
GTGGCTATTT TGTTTTATAC ATTGAACAGC AATGTTCATT CTGACTTTAC TAGAGCCATG 
GCCTCTGTTG CCAGGACTCC ACAGCAGTAT GAACGTTCAT TCCACTTCAA ATATTTACAC 
TACTACCTCA CCTCAGCAAT CCAGCTGCTG AGGAAAGACA GCATCATGGA GAATGGCACT 
CTGTGCTATG AGGTGCATTA TAGGACGAAG GATGTCCACT TTAATGCCTA CACAGGGGCC 
ACCATTCGAT TTGGCCAATT CCTCTCCACA TCCCTCCTGA AAGAAGAGGC ACAGGAGTTT 
GGGAACCAGA CACTATTTAC CATATTCACC TGCCTGGGTG CACCTGTACA GTACTTCTCC 
CTCAAGAAGG AAGTCTTGAT CCCTCCCTAT GAGCTGTTTA AAGTTATAAA TATGAGCTAC 
CACCCAAGAG GAGACTGGTT GCAGTTGAGG TCAACTGGGA ACCTGAGCAC ATATAACTGT 
CAGCTGCTAA AAGGTATTCT TTATCTAAAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ART4 ( NM_021071.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_066549.2 Homo sapiens ADP-ribosyltransferase 4 (Dombrock blood group) (ART4), transcript variant 1, mRNA.

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CloneID	OHu18469
Clone ID Related Accession (Same CDS sequence)	NM_021071.2 , NM_021071.3 , NM_021071.4
Accession Version	NM_021071.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1566662400000
Organism	Homo sapiens(human)
Product	ecto-ADP-ribosyltransferase 4 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007655.1, CR746266.1, AF290204.1 and BX096478.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_021071.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK291662.1, AY829434.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2142363 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000228936.6/ ENSP00000228936.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGTCCAT TGATCAACAG ATGCAAGAAG ATTCTTCTCC CAACTACTGT ACCTCCTGCA 
ACGATGAGAA TCTGGCTCCT TGGAGGCCTG CTGCCATTCC TGCTGCTCCT CTCTGGCCTG 
CAGAGACCCA CAGAGGGTTC TGAGGTTGCA ATTAAAATCG ACTTCGACTT CGCACCAGGT 
TCTTTTGATG ATCAGTACCA AGGCTGTAGC AAACAGGTTA TGGAGAAACT AACTCAAGGG 
GATTATTTCA CAAAAGACAT AGAAGCCCAG AAGAATTATT TTAGGATGTG GCAAAAAGCC 
CACTTAGCCT GGCTTAACCA AGGAAAAGTT CTACCCCAGA ACATGACTAC CACACACGCT 
GTGGCTATTT TGTTTTATAC ATTGAACAGC AATGTTCATT CTGACTTTAC TAGAGCCATG 
GCCTCTGTTG CCAGGACTCC ACAGCAGTAT GAACGTTCAT TCCACTTCAA ATATTTACAC 
TACTACCTCA CCTCAGCAAT CCAGCTGCTG AGGAAAGACA GCATCATGGA GAATGGCACT 
CTGTGCTATG AGGTGCATTA TAGGACGAAG GATGTCCACT TTAATGCCTA CACAGGGGCC 
ACCATTCGAT TTGGCCAATT CCTCTCCACA TCCCTCCTGA AAGAAGAGGC ACAGGAGTTT 
GGGAACCAGA CACTATTTAC CATATTCACC TGCCTGGGTG CACCTGTACA GTACTTCTCC 
CTCAAGAAGG AAGTCTTGAT CCCTCCCTAT GAGCTGTTTA AAGTTATAAA TATGAGCTAC 
CACCCAAGAG GAGACTGGTT GCAGTTGAGG TCAACTGGGA ACCTGAGCAC ATATAACTGT 
CAGCTGCTAA AAGCTTCCAG CAAGAAATGC ATCCCTGATC CTATAGCTAT TGCATCTCTC 
TCCTTTTTGA CCAGTGTCAT CATCTTTTCC AAAAGCAGAG TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066549.2
CDS	414..1358
Translation	MGPLINRCKKILLPTTVPPATMRIWLLGGLLPFLLLLSGLQRPTEGSEVAIKIDFDFAPGSFDDQYQGCSKQVMEKLTQGDYFTKDIEAQKNYFRMWQKAHLAWLNQGKVLPQNMTTTHAVAILFYTLNSNVHSDFTRAMASVARTPQQYERSFHFKYLHYYLTSAIQLLRKDSIMENGTLCYEVHYRTKDVHFNAYTGATIRFGQFLSTSLLKEEAQEFGNQTLFTIFTCLGAPVQYFSLKKEVLIPPYELFKVINMSYHPRGDWLQLRSTGNLSTYNCQLLKASSKKCIPDPIAIASLSFLTSVIIFSKSRV

Target ORF information:

RefSeq Version	NM_021071.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ADP-ribosyltransferase 4 (Dombrock blood group) (ART4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021071.4

ORF Insert Sequence:

ATGGGTCCAT TGATCAACAG ATGCAAGAAG ATTCTTCTCC CAACTACTGT ACCTCCTGCA 
ACGATGAGAA TCTGGCTCCT TGGAGGCCTG CTGCCATTCC TGCTGCTCCT CTCTGGCCTG 
CAGAGACCCA CAGAGGGTTC TGAGGTTGCA ATTAAAATCG ACTTCGACTT CGCACCAGGT 
TCTTTTGATG ATCAGTACCA AGGCTGTAGC AAACAGGTTA TGGAGAAACT AACTCAAGGG 
GATTATTTCA CAAAAGACAT AGAAGCCCAG AAGAATTATT TTAGGATGTG GCAAAAAGCC 
CACTTAGCCT GGCTTAACCA AGGAAAAGTT CTACCCCAGA ACATGACTAC CACACACGCT 
GTGGCTATTT TGTTTTATAC ATTGAACAGC AATGTTCATT CTGACTTTAC TAGAGCCATG 
GCCTCTGTTG CCAGGACTCC ACAGCAGTAT GAACGTTCAT TCCACTTCAA ATATTTACAC 
TACTACCTCA CCTCAGCAAT CCAGCTGCTG AGGAAAGACA GCATCATGGA GAATGGCACT 
CTGTGCTATG AGGTGCATTA TAGGACGAAG GATGTCCACT TTAATGCCTA CACAGGGGCC 
ACCATTCGAT TTGGCCAATT CCTCTCCACA TCCCTCCTGA AAGAAGAGGC ACAGGAGTTT 
GGGAACCAGA CACTATTTAC CATATTCACC TGCCTGGGTG CACCTGTACA GTACTTCTCC 
CTCAAGAAGG AAGTCTTGAT CCCTCCCTAT GAGCTGTTTA AAGTTATAAA TATGAGCTAC 
CACCCAAGAG GAGACTGGTT GCAGTTGAGG TCAACTGGGA ACCTGAGCAC ATATAACTGT 
CAGCTGCTAA AAGCTTCCAG CAAGAAATGC ATCCCTGATC CTATAGCTAT TGCATCTCTC 
TCCTTTTTGA CCAGTGTCAT CATCTTTTCC AAAAGCAGAG TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sequencing of the ART4 gene in sub-Saharan cohorts reveals ethnic differences and two new DO alleles: DO*B-Ile5Thr and DO*B-Trp266Arg.
Transfusion55(10)2376-83(2015 Oct)
Durousseau de Coulgeans C,Chiaroni J,Bailly P,Chapel-Fernandes S

A novel DO null allele with a c.268C>T (p.Gln90Stop) mutation in Japanese.
Vox sanguinis109(2)191-3(2015 Aug)
Onodera T,Tsuneyama H,Ogasawara K,Isa K,Satake M,Tadokoro K,Uchikawa M

The production, serologic evaluation, and epitope mapping of ten murine monoclonal Dombrock antibodies.
Immunohematology28(4)124-9(2012)
Grodecka M,Wasniowska K,Halverson G,Yazdanbakhsh K,Reid ME,Lisowska E

Single PCR multiplex SNaPshot reaction for detection of eleven blood group nucleotide polymorphisms: optimization, validation, and one year of routine clinical use.
The Journal of molecular diagnostics : JMD12(4)453-60(2010 Jul)
Di Cristofaro J,Silvy M,Chiaroni J,Bailly P

The Dombrock blood group system: a review.
Immunohematology26(2)71-8(2010)
Lomas-Francis C,Reid ME

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ART4 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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