APOBEC4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	APOBEC4
Entrez Gene ID	403314
Full Name	apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4
Synonyms	C1orf169
General protein information	Preferred Names apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4 Names putative C->U-editing enzyme APOBEC-4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q25.3
Summary	This gene encodes a member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral infection. [provided by RefSeq, Jul 2008].
Disorder MIM:	609908

mRNA and Protein(s)

mRNA	Protein	Name
NM_203454.2	NP_982279.1	putative C->U-editing enzyme APOBEC-4
NM_203454.3	NP_982279.1	putative C->U-editing enzyme APOBEC-4

Pathways from BioSystems

Homologies

Bos taurus (cattle)	APOBEC4	XP_002694256.1
Xenopus tropicalis (tropical clawed frog)	apobec4	XP_002933811.2
Mus musculus (house mouse)	Apobec4	NP_001074666.1
Pan troglodytes (chimpanzee)	APOBEC4	XP_001163612.1
Macaca mulatta (Rhesus monkey)	APOBEC4	XP_001114088.1
Gallus gallus (chicken)	APOBEC4	XP_004943337.1
Homo sapiens (human)	APOBEC4	NP_982279.1
Canis lupus familiaris (dog)	APOBEC4	XP_005622485.1
Rattus norvegicus (Norway rat)	Apobec4	NP_001017492.1

Gene Ontology
Bibliography

Related articles in PubMed

APOBEC4 Enhances the Replication of HIV-1.
Marino D, Perković M, Hain A, Jaguva Vasudevan AA, Hofmann H, Hanschmann KM, Mühlebach MD, Schumann GG, König R, Cichutek K, Häussinger D, Münk C
PloS one11(6)e0155422(2016)

Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
Yang W, Tang H, Zhang Y, Tang X, Zhang J, Sun L, Yang J, Cui Y, Zhang L, Hirankarn N, Cheng H, Pan HF, Gao J, Lee TL, Sheng Y, Lau CS, Li Y, Chan TM, Yin X, Ying D, Lu Q, Leung AM, Zuo X, Chen X, Tong KL, Zhou F, Diao Q, Tse NK, Xie H, Mok CC, Hao F, Wong SN, Shi B, Lee KW, Hui Y, Ho MH, Liang B, Lee PP, Cui H, Guo Q, Chung BH, Pu X, Liu Q, Zhang X, Zhang C, Chong CY, Fang H, Wong RW, Sun Y, Mok MY, Li XP, Avihingsanon Y, Zhai Z, Rianthavorn P, Deekajorndej T, Suphapeetiporn K, Gao F, Shotelersuk V, Kang X, Ying SK, Zhang L, Wong WH, Zhu D, Fung SK, Zeng F, Lai WM, Wong CM, Ng IO, Garcia-Barceló MM, Cherny SS, Shen N, Tam PK, Sham PC, Ye DQ, Yang S, Zhang X, Lau YL
American journal of human genetics92(1)41-51(2013 Jan)

APOBEC deaminases-mutases with defensive roles for immunity.
Prochnow C, Bransteitter R, Chen XS
Science in China. Series C, Life sciences52(10)893-902(2009 Oct)

APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis.
Rogozin IB, Basu MK, Jordan IK, Pavlov YI, Koonin EV
Cell cycle (Georgetown, Tex.)4(9)1281-5(2005 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following APOBEC4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the APOBEC4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30532	NM_203454.3 Latest version!	Homo sapiens apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4 (APOBEC4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
View Old Accession Versions >>
OHu30532	NM_203454.2	Homo sapiens apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4 (APOBEC4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

APOBEC4 ( NM_203454.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_982279.1 Homo sapiens apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4 (APOBEC4), mRNA.

Price & Availability↑

CloneID	OHu30532
Clone ID Related Accession (Same CDS sequence)	NM_203454.2 , NM_203454.3
Accession Version	NM_203454.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1104bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1514217600000
Organism	Homo sapiens(human)
Product	putative C->U-editing enzyme APOBEC-4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC021711.2 and AI961390.1. On Jul 14, 2006 this sequence version replaced NM_203454.1. ##Evidence-Data-START## Transcript exon combination :: BC021711.2, AK098557.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCCA TATATGAGGA GTACCTAGCA AATCATGGAA CAATAGTAAA ACCATATTAC 
TGGCTAAGCT TCTCTCTCGA TTGCTCTAAT TGTCCTTACC ATATTCGAAC AGGTGAAGAA 
GCAAGAGTTT CCCTCACAGA ATTTTGTCAG ATTTTTGGAT TCCCTTATGG GACAACATTT 
CCTCAAACAA AACACCTCAC ATTTTATGAA CTAAAAACTT CTTCTGGTAG CCTGGTGCAA 
AAGGGCCATG CTAGCAGTTG CACTGGGAAT TATATCCATC CAGAATCAAT GCTCTTTGAA 
ATGAATGGTT ATCTTGACTC AGCCATATAC AATAATGACA GCATCAGGCA TATCATTCTG 
TATTCCAACA ACTCCCCTTG TAATGAAGCT AACCACTGCT GCATCAGCAA AATGTATAAT 
TTCCTGATTA CGTATCCAGG CATCACTCTT AGTATTTATT TTTCTCAGCT CTATCATACT 
GAGATGGACT TTCCTGCCTC AGCATGGAAC CGCGAAGCTC TCCGGAGCCT GGCCAGCTTA 
TGGCCGCGGG TTGTTTTGAG TCCAATAAGT GGTGGGATCT GGCATTCTGT TCTCCACAGC 
TTTATAAGTG GTGTCTCAGG ATCACATGTT TTTCAGCCCA TTTTAACTGG GAGAGCACTG 
GCTGACAGGC ACAACGCATA TGAAATCAAT GCCATAACAG GCGTAAAACC TTACTTCACT 
GATGTTCTTC TCCAGACAAA AAGGAATCCA AACACAAAAG CTCAGGAGGC TTTAGAGAGC 
TACCCCTTAA ACAATGCCTT TCCTGGACAG TTTTTTCAAA TGCCGAGTGG ACAACTCCAA 
CCCAACCTAC CTCCAGACCT CAGGGCTCCT GTTGTTTTTG TGCTAGTGCC TCTCAGGGAC 
TTACCACCAA TGCATATGGG CCAAAACCCA AATAAACCCA GGAATATCGT AAGGCACTTA 
AATATGCCTC AAATGTCATT CCAGGAAACC AAGGACCTTG GAAGGCTTCC CACTGGAAGG 
TCAGTGGAGA TAGTGGAAAT CACAGAACAG TTTGCAAGTA GCAAGGAGGC AGATGAAAAG 
AAGAAGAAGA AAGGGAAGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_982279.1
CDS	273..1376
Translation	MEPIYEEYLANHGTIVKPYYWLSFSLDCSNCPYHIRTGEEARVSLTEFCQIFGFPYGTTFPQTKHLTFYELKTSSGSLVQKGHASSCTGNYIHPESMLFEMNGYLDSAIYNNDSIRHIILYSNNSPCNEANHCCISKMYNFLITYPGITLSIYFSQLYHTEMDFPASAWNREALRSLASLWPRVVLSPISGGIWHSVLHSFISGVSGSHVFQPILTGRALADRHNAYEINAITGVKPYFTDVLLQTKRNPNTKAQEALESYPLNNAFPGQFFQMPSGQLQPNLPPDLRAPVVFVLVPLRDLPPMHMGQNPNKPRNIVRHLNMPQMSFQETKDLGRLPTGRSVEIVEITEQFASSKEADEKKKKKGKK

Target ORF information:

RefSeq Version	NM_203454.2
Organism	Homo sapiens(human)
Definition	Homo sapiens apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4 (APOBEC4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_203454.2

ORF Insert Sequence:

ATGGAGCCCA TATATGAGGA GTACCTAGCA AATCATGGAA CAATAGTAAA ACCATATTAC 
TGGCTAAGCT TCTCTCTCGA TTGCTCTAAT TGTCCTTACC ATATTCGAAC AGGTGAAGAA 
GCAAGAGTTT CCCTCACAGA ATTTTGTCAG ATTTTTGGAT TCCCTTATGG GACAACATTT 
CCTCAAACAA AACACCTCAC ATTTTATGAA CTAAAAACTT CTTCTGGTAG CCTGGTGCAA 
AAGGGCCATG CTAGCAGTTG CACTGGGAAT TATATCCATC CAGAATCAAT GCTCTTTGAA 
ATGAATGGTT ATCTTGACTC AGCCATATAC AATAATGACA GCATCAGGCA TATCATTCTG 
TATTCCAACA ACTCCCCTTG TAATGAAGCT AACCACTGCT GCATCAGCAA AATGTATAAT 
TTCCTGATTA CGTATCCAGG CATCACTCTT AGTATTTATT TTTCTCAGCT CTATCATACT 
GAGATGGACT TTCCTGCCTC AGCATGGAAC CGCGAAGCTC TCCGGAGCCT GGCCAGCTTA 
TGGCCGCGGG TTGTTTTGAG TCCAATAAGT GGTGGGATCT GGCATTCTGT TCTCCACAGC 
TTTATAAGTG GTGTCTCAGG ATCACATGTT TTTCAGCCCA TTTTAACTGG GAGAGCACTG 
GCTGACAGGC ACAACGCATA TGAAATCAAT GCCATAACAG GCGTAAAACC TTACTTCACT 
GATGTTCTTC TCCAGACAAA AAGGAATCCA AACACAAAAG CTCAGGAGGC TTTAGAGAGC 
TACCCCTTAA ACAATGCCTT TCCTGGACAG TTTTTTCAAA TGCCGAGTGG ACAACTCCAA 
CCCAACCTAC CTCCAGACCT CAGGGCTCCT GTTGTTTTTG TGCTAGTGCC TCTCAGGGAC 
TTACCACCAA TGCATATGGG CCAAAACCCA AATAAACCCA GGAATATCGT AAGGCACTTA 
AATATGCCTC AAATGTCATT CCAGGAAACC AAGGACCTTG GAAGGCTTCC CACTGGAAGG 
TCAGTGGAGA TAGTGGAAAT CACAGAACAG TTTGCAAGTA GCAAGGAGGC AGATGAAAAG 
AAGAAGAAGA AAGGGAAGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

APOBEC4 ( NM_203454.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_982279.1 Homo sapiens apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4 (APOBEC4), mRNA.

Price & Availability↑

CloneID	OHu30532
Clone ID Related Accession (Same CDS sequence)	NM_203454.2 , NM_203454.3
Accession Version	NM_203454.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1104bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1556640000000
Organism	Homo sapiens(human)
Product	putative C->U-editing enzyme APOBEC-4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL137800.12, BC021711.2 and AI961390.1. On Nov 22, 2018 this sequence version replaced NM_203454.2. ##Evidence-Data-START## Transcript exon combination :: BC021711.2, SRR5189667.353799.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000308641.6/ ENSP00000310622.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGCCCA TATATGAGGA GTACCTAGCA AATCATGGAA CAATAGTAAA ACCATATTAC 
TGGCTAAGCT TCTCTCTCGA TTGCTCTAAT TGTCCTTACC ATATTCGAAC AGGTGAAGAA 
GCAAGAGTTT CCCTCACAGA ATTTTGTCAG ATTTTTGGAT TCCCTTATGG GACAACATTT 
CCTCAAACAA AACACCTCAC ATTTTATGAA CTAAAAACTT CTTCTGGTAG CCTGGTGCAA 
AAGGGCCATG CTAGCAGTTG CACTGGGAAT TATATCCATC CAGAATCAAT GCTCTTTGAA 
ATGAATGGTT ATCTTGACTC AGCCATATAC AATAATGACA GCATCAGGCA TATCATTCTG 
TATTCCAACA ACTCCCCTTG TAATGAAGCT AACCACTGCT GCATCAGCAA AATGTATAAT 
TTCCTGATTA CGTATCCAGG CATCACTCTT AGTATTTATT TTTCTCAGCT CTATCATACT 
GAGATGGACT TTCCTGCCTC AGCATGGAAC CGCGAAGCTC TCCGGAGCCT GGCCAGCTTA 
TGGCCGCGGG TTGTTTTGAG TCCAATAAGT GGTGGGATCT GGCATTCTGT TCTCCACAGC 
TTTATAAGTG GTGTCTCAGG ATCACATGTT TTTCAGCCCA TTTTAACTGG GAGAGCACTG 
GCTGACAGGC ACAACGCATA TGAAATCAAT GCCATAACAG GCGTAAAACC TTACTTCACT 
GATGTTCTTC TCCAGACAAA AAGGAATCCA AACACAAAAG CTCAGGAGGC TTTAGAGAGC 
TACCCCTTAA ACAATGCCTT TCCTGGACAG TTTTTTCAAA TGCCGAGTGG ACAACTCCAA 
CCCAACCTAC CTCCAGACCT CAGGGCTCCT GTTGTTTTTG TGCTAGTGCC TCTCAGGGAC 
TTACCACCAA TGCATATGGG CCAAAACCCA AATAAACCCA GGAATATCGT AAGGCACTTA 
AATATGCCTC AAATGTCATT CCAGGAAACC AAGGACCTTG GAAGGCTTCC CACTGGAAGG 
TCAGTGGAGA TAGTGGAAAT CACAGAACAG TTTGCAAGTA GCAAGGAGGC AGATGAAAAG 
AAGAAGAAGA AAGGGAAGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_982279.1
CDS	276..1379
Translation	MEPIYEEYLANHGTIVKPYYWLSFSLDCSNCPYHIRTGEEARVSLTEFCQIFGFPYGTTFPQTKHLTFYELKTSSGSLVQKGHASSCTGNYIHPESMLFEMNGYLDSAIYNNDSIRHIILYSNNSPCNEANHCCISKMYNFLITYPGITLSIYFSQLYHTEMDFPASAWNREALRSLASLWPRVVLSPISGGIWHSVLHSFISGVSGSHVFQPILTGRALADRHNAYEINAITGVKPYFTDVLLQTKRNPNTKAQEALESYPLNNAFPGQFFQMPSGQLQPNLPPDLRAPVVFVLVPLRDLPPMHMGQNPNKPRNIVRHLNMPQMSFQETKDLGRLPTGRSVEIVEITEQFASSKEADEKKKKKGKK

Target ORF information:

RefSeq Version	NM_203454.3
Organism	Homo sapiens(human)
Definition	Homo sapiens apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4 (APOBEC4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_203454.3

ORF Insert Sequence:

ATGGAGCCCA TATATGAGGA GTACCTAGCA AATCATGGAA CAATAGTAAA ACCATATTAC 
TGGCTAAGCT TCTCTCTCGA TTGCTCTAAT TGTCCTTACC ATATTCGAAC AGGTGAAGAA 
GCAAGAGTTT CCCTCACAGA ATTTTGTCAG ATTTTTGGAT TCCCTTATGG GACAACATTT 
CCTCAAACAA AACACCTCAC ATTTTATGAA CTAAAAACTT CTTCTGGTAG CCTGGTGCAA 
AAGGGCCATG CTAGCAGTTG CACTGGGAAT TATATCCATC CAGAATCAAT GCTCTTTGAA 
ATGAATGGTT ATCTTGACTC AGCCATATAC AATAATGACA GCATCAGGCA TATCATTCTG 
TATTCCAACA ACTCCCCTTG TAATGAAGCT AACCACTGCT GCATCAGCAA AATGTATAAT 
TTCCTGATTA CGTATCCAGG CATCACTCTT AGTATTTATT TTTCTCAGCT CTATCATACT 
GAGATGGACT TTCCTGCCTC AGCATGGAAC CGCGAAGCTC TCCGGAGCCT GGCCAGCTTA 
TGGCCGCGGG TTGTTTTGAG TCCAATAAGT GGTGGGATCT GGCATTCTGT TCTCCACAGC 
TTTATAAGTG GTGTCTCAGG ATCACATGTT TTTCAGCCCA TTTTAACTGG GAGAGCACTG 
GCTGACAGGC ACAACGCATA TGAAATCAAT GCCATAACAG GCGTAAAACC TTACTTCACT 
GATGTTCTTC TCCAGACAAA AAGGAATCCA AACACAAAAG CTCAGGAGGC TTTAGAGAGC 
TACCCCTTAA ACAATGCCTT TCCTGGACAG TTTTTTCAAA TGCCGAGTGG ACAACTCCAA 
CCCAACCTAC CTCCAGACCT CAGGGCTCCT GTTGTTTTTG TGCTAGTGCC TCTCAGGGAC 
TTACCACCAA TGCATATGGG CCAAAACCCA AATAAACCCA GGAATATCGT AAGGCACTTA 
AATATGCCTC AAATGTCATT CCAGGAAACC AAGGACCTTG GAAGGCTTCC CACTGGAAGG 
TCAGTGGAGA TAGTGGAAAT CACAGAACAG TTTGCAAGTA GCAAGGAGGC AGATGAAAAG 
AAGAAGAAGA AAGGGAAGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

APOBEC4 Enhances the Replication of HIV-1.
PloS one11(6)e0155422(2016)
Marino D,Perković M,Hain A,Jaguva Vasudevan AA,Hofmann H,Hanschmann KM,Mühlebach MD,Schumann GG,König R,Cichutek K,Häussinger D,Münk C

Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
American journal of human genetics92(1)41-51(2013 Jan)
Yang W,Tang H,Zhang Y,Tang X,Zhang J,Sun L,Yang J,Cui Y,Zhang L,Hirankarn N,Cheng H,Pan HF,Gao J,Lee TL,Sheng Y,Lau CS,Li Y,Chan TM,Yin X,Ying D,Lu Q,Leung AM,Zuo X,Chen X,Tong KL,Zhou F,Diao Q,Tse NK,Xie H,Mok CC,Hao F,Wong SN,Shi B,Lee KW,Hui Y,Ho MH,Liang B,Lee PP,Cui H,Guo Q,Chung BH,Pu X,Liu Q,Zhang X,Zhang C,Chong CY,Fang H,Wong RW,Sun Y,Mok MY,Li XP,Avihingsanon Y,Zhai Z,Rianthavorn P,Deekajorndej T,Suphapeetiporn K,Gao F,Shotelersuk V,Kang X,Ying SK,Zhang L,Wong WH,Zhu D,Fung SK,Zeng F,Lai WM,Wong CM,Ng IO,Garcia-Barceló MM,Cherny SS,Shen N,Tam PK,Sham PC,Ye DQ,Yang S,Zhang X,Lau YL

APOBEC deaminases-mutases with defensive roles for immunity.
Science in China. Series C, Life sciences52(10)893-902(2009 Oct)
Prochnow C,Bransteitter R,Chen XS

APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis.
Cell cycle (Georgetown, Tex.)4(9)1281-5(2005 Sep)
Rogozin IB,Basu MK,Jordan IK,Pavlov YI,Koonin EV

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APOBEC4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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