USP27X cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	USP27X
Entrez Gene ID	389856
Full Name	ubiquitin specific peptidase 27, X-linked
Synonyms	MRX105,USP22L,USP27
General protein information	Preferred Names ubiquitin specific peptidase 27, X-linked Names ubiquitin carboxyl-terminal hydrolase 27 X-linked ubiquitin carboxyl-terminal hydrolase 27 deubiquitinating enzyme 27 ubiquitin specific protease 27, X chromosome ubiquitin thioesterase 27 ubiquitin-specific-processing protease 27
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp11.23
Summary	This gene encodes a member of the peptidase protein family. The encoded protein functions as a deubiquitinase that is involved in upregulation of the pro-apoptotic Bim protein. This protein may act as a tumor suppressor by increasing levels of Bim to counteract anti-apoptotic signals in cancer cells. Mutations in this gene have been associated with X-linked cognitive disability. [provided by RefSeq, Dec 2016].
Disorder MIM:	300975
Disorder Html:	Mental retardation 105, 300984 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001145073.2	NP_001138545.1	ubiquitin carboxyl-terminal hydrolase 27
NM_001145073.3	NP_001138545.1	ubiquitin carboxyl-terminal hydrolase 27

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Usp27x	NP_062334.2
Arabidopsis thaliana (thale cress)	UBP22	NP_568239.1
Rattus norvegicus (Norway rat)	Usp27x	XP_006256824.1
Canis lupus familiaris (dog)	LOC100686687	XP_005642147.1
Homo sapiens (human)	USP27X	NP_001138545.1
Bos taurus (cattle)	USP27X	NP_001138547.1
Pan troglodytes (chimpanzee)	LOC100614099	XP_003317508.1

Gene Ontology
Bibliography

Related articles in PubMed

TGFβ-Activated USP27X Deubiquitinase Regulates Cell Migration and Chemoresistance via Stabilization of Snail1.
Lambies G, Miceli M, Martínez-Guillamon C, Olivera-Salguero R, Peña R, Frías CP, Calderón I, Atanassov BS, Dent SYR, Arribas J, García de Herreros A, Díaz VM
Cancer research79(1)33-46(2019 01)

USP27-mediated Cyclin E stabilization drives cell cycle progression and hepatocellular tumorigenesis.
Dong L, Yu L, Bai C, Liu L, Long H, Shi L, Lin Z
Oncogene37(20)2702-2713(2018 05)

The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis.
Weber A, Heinlein M, Dengjel J, Alber C, Singh PK, Häcker G
EMBO reports17(5)724-38(2016 05)

ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth.
Atanassov BS, Mohan RD, Lan X, Kuang X, Lu Y, Lin K, McIvor E, Li W, Zhang Y, Florens L, Byrum SD, Mackintosh SG, Calhoun-Davis T, Koutelou E, Wang L, Tang DG, Tackett AJ, Washburn MP, Workman JL, Dent SY
Molecular cell62(4)558-71(2016 05)

X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes.
Hu H, Haas SA, Chelly J, Van Esch H, Raynaud M, de Brouwer AP, Weinert S, Froyen G, Frints SG, Laumonnier F, Zemojtel T, Love MI, Richard H, Emde AK, Bienek M, Jensen C, Hambrock M, Fischer U, Langnick C, Feldkamp M, Wissink-Lindhout W, Lebrun N, Castelnau L, Rucci J, Montjean R, Dorseuil O, Billuart P, Stuhlmann T, Shaw M, Corbett MA, Gardner A, Willis-Owen S, Tan C, Friend KL, Belet S, van Roozendaal KE, Jimenez-Pocquet M, Moizard MP, Ronce N, Sun R, O'Keeffe S, Chenna R, van Bömmel A, Göke J, Hackett A, Field M, Christie L, Boyle J, Haan E, Nelson J, Turner G, Baynam G, Gillessen-Kaesbach G, Müller U, Steinberger D, Budny B, Badura-Stronka M, Latos-Bieleńska A, Ousager LB, Wieacker P, Rodríguez Criado G, Bondeson ML, Annerén G, Dufke A, Cohen M, Van Maldergem L, Vincent-Delorme C, Echenne B, Simon-Bouy B, Kleefstra T, Willemsen M, Fryns JP, Devriendt K, Ullmann R, Vingron M, Wrogemann K, Wienker TF, Tzschach A, van Bokhoven H, Gecz J, Jentsch TJ, Chen W, Ropers HH, Kalscheuer VM
Molecular psychiatry21(1)133-48(2016 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following USP27X gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the USP27X cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01855	NM_001145073.3 Latest version!	Homo sapiens ubiquitin specific peptidase 27 X-linked (USP27X), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
View Old Accession Versions >>
OHu01855	NM_001145073.2	Homo sapiens ubiquitin specific peptidase 27 X-linked (USP27X), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

USP27X ( NM_001145073.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001138545.1 Homo sapiens ubiquitin specific peptidase 27 X-linked (USP27X), mRNA.

Price & Availability↑

CloneID	OHu01855
Clone ID Related Accession (Same CDS sequence)	NM_001145073.2 , NM_001145073.3
Accession Version	NM_001145073.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1317bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1551542400000
Organism	Homo sapiens(human)
Product	ubiquitin carboxyl-terminal hydrolase 27
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC236430.4. This sequence is a reference standard in the RefSeqGene project. On Aug 22, 2013 this sequence version replaced NM_001145073.1. Sequence Note: The RefSeq transcript was derived from the reference genome assembly. The genomic coordinates were determined from alignments. COMPLETENESS: complete on the 3' end.

ATGTGTAAGG ACTATGTATA TGACAAAGAC ATTGAGCAAA TTGCCAAAGA AGAGCAAGGA 
GAAGCTTTGA AATTACAAGC CTCCACCTCA ACAGAGGTTT CTCACCAGCA GTGTTCAGTG 
CCAGGCCTTG GTGAGAAATT CCCAACCTGG GAAACAACCA AACCAGAATT AGAACTGCTG 
GGGCACAACC CGAGGAGAAG AAGAATCACC TCCAGCTTTA CGATCGGTTT AAGAGGACTC 
ATCAATCTTG GCAACACGTG CTTTATGAAC TGCATTGTCC AGGCCCTCAC CCACACGCCG 
ATACTGAGAG ATTTCTTTCT CTCTGACAGG CACCGATGTG AGATGCCGAG TCCCGAGTTG 
TGTCTGGTCT GTGAGATGTC GTCGCTGTTT CGGGAGTTGT ATTCTGGAAA CCCGTCTCCT 
CATGTGCCCT ATAAGTTACT GCACCTGGTG TGGATACATG CCCGCCATTT AGCAGGGTAC 
AGGCAACAGG ATGCCCACGA GTTCCTCATT GCAGCGTTAG ATGTCCTGCA CAGGCACTGC 
AAAGGTGATG ATGTCGGGAA GGCGGCCAAC AATCCCAACC ACTGTAACTG CATCATAGAC 
CAAATCTTCA CAGGTGGCCT GCAGTCTGAT GTCACCTGTC AAGCCTGCCA TGGCGTCTCC 
ACCACGATAG ACCCATGCTG GGACATTAGT TTGGACTTGC CTGGCTCTTG CACCTCCTTC 
TGGCCCATGA GCCCAGGGAG GGAGAGCAGT GTGAACGGGG AAAGCCACAT ACCAGGAATC 
ACCACCCTCA CGGACTGCTT GCGGAGGTTT ACGAGGCCAG AGCACTTAGG AAGCAGTGCC 
AAAATCAAAT GTGGTAGTTG CCAAAGCTAC CAGGAATCTA CCAAACAGCT CACAATGAAT 
AAATTACCTG TCGTTGCCTG TTTTCATTTC AAACGGTTTG AACATTCAGC GAAACAGAGG 
CGCAAGATCA CTACATACAT TTCCTTTCCT CTGGAGCTGG ATATGACGCC GTTTATGGCC 
TCAAGTAAAG AGAGCAGAAT GAATGGACAA TTGCAGCTGC CAACCAATAG TGGAAACAAC 
GAAAATAAGT ATTCCTTGTT TGCTGTGGTT AATCACCAAG GAACCTTGGA GAGTGGCCAC 
TATACCAGCT TCATCCGGCA CCACAAGGAC CAGTGGTTCA AGTGTGATGA TGCCGTCATC 
ACTAAGGCCA GTATTAAGGA CGTACTGGAC AGTGAAGGGT ATTTACTGTT CTATCACAAA 
CAGGTGCTAG AACATGAGTC AGAAAAAGTG AAAGAAATGA ACACACAAGC CTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001138545.1
CDS	442..1758
Translation	MCKDYVYDKDIEQIAKEEQGEALKLQASTSTEVSHQQCSVPGLGEKFPTWETTKPELELLGHNPRRRRITSSFTIGLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEMPSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCKGDDVGKAANNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGSCTSFWPMSPGRESSVNGESHIPGITTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRFEHSAKQRRKITTYISFPLELDMTPFMASSKESRMNGQLQLPTNSGNNENKYSLFAVVNHQGTLESGHYTSFIRHHKDQWFKCDDAVITKASIKDVLDSEGYLLFYHKQVLEHESEKVKEMNTQAY

Target ORF information:

RefSeq Version	NM_001145073.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquitin specific peptidase 27 X-linked (USP27X), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145073.2

ORF Insert Sequence:

ATGTGTAAGG ACTATGTATA TGACAAAGAC ATTGAGCAAA TTGCCAAAGA AGAGCAAGGA 
GAAGCTTTGA AATTACAAGC CTCCACCTCA ACAGAGGTTT CTCACCAGCA GTGTTCAGTG 
CCAGGCCTTG GTGAGAAATT CCCAACCTGG GAAACAACCA AACCAGAATT AGAACTGCTG 
GGGCACAACC CGAGGAGAAG AAGAATCACC TCCAGCTTTA CGATCGGTTT AAGAGGACTC 
ATCAATCTTG GCAACACGTG CTTTATGAAC TGCATTGTCC AGGCCCTCAC CCACACGCCG 
ATACTGAGAG ATTTCTTTCT CTCTGACAGG CACCGATGTG AGATGCCGAG TCCCGAGTTG 
TGTCTGGTCT GTGAGATGTC GTCGCTGTTT CGGGAGTTGT ATTCTGGAAA CCCGTCTCCT 
CATGTGCCCT ATAAGTTACT GCACCTGGTG TGGATACATG CCCGCCATTT AGCAGGGTAC 
AGGCAACAGG ATGCCCACGA GTTCCTCATT GCAGCGTTAG ATGTCCTGCA CAGGCACTGC 
AAAGGTGATG ATGTCGGGAA GGCGGCCAAC AATCCCAACC ACTGTAACTG CATCATAGAC 
CAAATCTTCA CAGGTGGCCT GCAGTCTGAT GTCACCTGTC AAGCCTGCCA TGGCGTCTCC 
ACCACGATAG ACCCATGCTG GGACATTAGT TTGGACTTGC CTGGCTCTTG CACCTCCTTC 
TGGCCCATGA GCCCAGGGAG GGAGAGCAGT GTGAACGGGG AAAGCCACAT ACCAGGAATC 
ACCACCCTCA CGGACTGCTT GCGGAGGTTT ACGAGGCCAG AGCACTTAGG AAGCAGTGCC 
AAAATCAAAT GTGGTAGTTG CCAAAGCTAC CAGGAATCTA CCAAACAGCT CACAATGAAT 
AAATTACCTG TCGTTGCCTG TTTTCATTTC AAACGGTTTG AACATTCAGC GAAACAGAGG 
CGCAAGATCA CTACATACAT TTCCTTTCCT CTGGAGCTGG ATATGACGCC GTTTATGGCC 
TCAAGTAAAG AGAGCAGAAT GAATGGACAA TTGCAGCTGC CAACCAATAG TGGAAACAAC 
GAAAATAAGT ATTCCTTGTT TGCTGTGGTT AATCACCAAG GAACCTTGGA GAGTGGCCAC 
TATACCAGCT TCATCCGGCA CCACAAGGAC CAGTGGTTCA AGTGTGATGA TGCCGTCATC 
ACTAAGGCCA GTATTAAGGA CGTACTGGAC AGTGAAGGGT ATTTACTGTT CTATCACAAA 
CAGGTGCTAG AACATGAGTC AGAAAAAGTG AAAGAAATGA ACACACAAGC CTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

USP27X ( NM_001145073.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001138545.1 Homo sapiens ubiquitin specific peptidase 27 X-linked (USP27X), mRNA.

Price & Availability↑

CloneID	OHu01855
Clone ID Related Accession (Same CDS sequence)	NM_001145073.2 , NM_001145073.3
Accession Version	NM_001145073.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1317bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1572105600000
Organism	Homo sapiens(human)
Product	ubiquitin carboxyl-terminal hydrolase 27
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC236430.4. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_001145073.2. Sequence Note: The RefSeq transcript was derived from the reference genome assembly. The genomic coordinates were determined from alignments. ##Evidence-Data-START## Transcript is intronless :: ERR279876.4827.1, DRR138528.6382.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000621775.2/ ENSP00000483631.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGTAAGG ACTATGTATA TGACAAAGAC ATTGAGCAAA TTGCCAAAGA AGAGCAAGGA 
GAAGCTTTGA AATTACAAGC CTCCACCTCA ACAGAGGTTT CTCACCAGCA GTGTTCAGTG 
CCAGGCCTTG GTGAGAAATT CCCAACCTGG GAAACAACCA AACCAGAATT AGAACTGCTG 
GGGCACAACC CGAGGAGAAG AAGAATCACC TCCAGCTTTA CGATCGGTTT AAGAGGACTC 
ATCAATCTTG GCAACACGTG CTTTATGAAC TGCATTGTCC AGGCCCTCAC CCACACGCCG 
ATACTGAGAG ATTTCTTTCT CTCTGACAGG CACCGATGTG AGATGCCGAG TCCCGAGTTG 
TGTCTGGTCT GTGAGATGTC GTCGCTGTTT CGGGAGTTGT ATTCTGGAAA CCCGTCTCCT 
CATGTGCCCT ATAAGTTACT GCACCTGGTG TGGATACATG CCCGCCATTT AGCAGGGTAC 
AGGCAACAGG ATGCCCACGA GTTCCTCATT GCAGCGTTAG ATGTCCTGCA CAGGCACTGC 
AAAGGTGATG ATGTCGGGAA GGCGGCCAAC AATCCCAACC ACTGTAACTG CATCATAGAC 
CAAATCTTCA CAGGTGGCCT GCAGTCTGAT GTCACCTGTC AAGCCTGCCA TGGCGTCTCC 
ACCACGATAG ACCCATGCTG GGACATTAGT TTGGACTTGC CTGGCTCTTG CACCTCCTTC 
TGGCCCATGA GCCCAGGGAG GGAGAGCAGT GTGAACGGGG AAAGCCACAT ACCAGGAATC 
ACCACCCTCA CGGACTGCTT GCGGAGGTTT ACGAGGCCAG AGCACTTAGG AAGCAGTGCC 
AAAATCAAAT GTGGTAGTTG CCAAAGCTAC CAGGAATCTA CCAAACAGCT CACAATGAAT 
AAATTACCTG TCGTTGCCTG TTTTCATTTC AAACGGTTTG AACATTCAGC GAAACAGAGG 
CGCAAGATCA CTACATACAT TTCCTTTCCT CTGGAGCTGG ATATGACGCC GTTTATGGCC 
TCAAGTAAAG AGAGCAGAAT GAATGGACAA TTGCAGCTGC CAACCAATAG TGGAAACAAC 
GAAAATAAGT ATTCCTTGTT TGCTGTGGTT AATCACCAAG GAACCTTGGA GAGTGGCCAC 
TATACCAGCT TCATCCGGCA CCACAAGGAC CAGTGGTTCA AGTGTGATGA TGCCGTCATC 
ACTAAGGCCA GTATTAAGGA CGTACTGGAC AGTGAAGGGT ATTTACTGTT CTATCACAAA 
CAGGTGCTAG AACATGAGTC AGAAAAAGTG AAAGAAATGA ACACACAAGC CTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001138545.1
CDS	825..2141
Translation	MCKDYVYDKDIEQIAKEEQGEALKLQASTSTEVSHQQCSVPGLGEKFPTWETTKPELELLGHNPRRRRITSSFTIGLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEMPSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCKGDDVGKAANNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGSCTSFWPMSPGRESSVNGESHIPGITTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRFEHSAKQRRKITTYISFPLELDMTPFMASSKESRMNGQLQLPTNSGNNENKYSLFAVVNHQGTLESGHYTSFIRHHKDQWFKCDDAVITKASIKDVLDSEGYLLFYHKQVLEHESEKVKEMNTQAY

Target ORF information:

RefSeq Version	NM_001145073.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquitin specific peptidase 27 X-linked (USP27X), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145073.3

ORF Insert Sequence:

ATGTGTAAGG ACTATGTATA TGACAAAGAC ATTGAGCAAA TTGCCAAAGA AGAGCAAGGA 
GAAGCTTTGA AATTACAAGC CTCCACCTCA ACAGAGGTTT CTCACCAGCA GTGTTCAGTG 
CCAGGCCTTG GTGAGAAATT CCCAACCTGG GAAACAACCA AACCAGAATT AGAACTGCTG 
GGGCACAACC CGAGGAGAAG AAGAATCACC TCCAGCTTTA CGATCGGTTT AAGAGGACTC 
ATCAATCTTG GCAACACGTG CTTTATGAAC TGCATTGTCC AGGCCCTCAC CCACACGCCG 
ATACTGAGAG ATTTCTTTCT CTCTGACAGG CACCGATGTG AGATGCCGAG TCCCGAGTTG 
TGTCTGGTCT GTGAGATGTC GTCGCTGTTT CGGGAGTTGT ATTCTGGAAA CCCGTCTCCT 
CATGTGCCCT ATAAGTTACT GCACCTGGTG TGGATACATG CCCGCCATTT AGCAGGGTAC 
AGGCAACAGG ATGCCCACGA GTTCCTCATT GCAGCGTTAG ATGTCCTGCA CAGGCACTGC 
AAAGGTGATG ATGTCGGGAA GGCGGCCAAC AATCCCAACC ACTGTAACTG CATCATAGAC 
CAAATCTTCA CAGGTGGCCT GCAGTCTGAT GTCACCTGTC AAGCCTGCCA TGGCGTCTCC 
ACCACGATAG ACCCATGCTG GGACATTAGT TTGGACTTGC CTGGCTCTTG CACCTCCTTC 
TGGCCCATGA GCCCAGGGAG GGAGAGCAGT GTGAACGGGG AAAGCCACAT ACCAGGAATC 
ACCACCCTCA CGGACTGCTT GCGGAGGTTT ACGAGGCCAG AGCACTTAGG AAGCAGTGCC 
AAAATCAAAT GTGGTAGTTG CCAAAGCTAC CAGGAATCTA CCAAACAGCT CACAATGAAT 
AAATTACCTG TCGTTGCCTG TTTTCATTTC AAACGGTTTG AACATTCAGC GAAACAGAGG 
CGCAAGATCA CTACATACAT TTCCTTTCCT CTGGAGCTGG ATATGACGCC GTTTATGGCC 
TCAAGTAAAG AGAGCAGAAT GAATGGACAA TTGCAGCTGC CAACCAATAG TGGAAACAAC 
GAAAATAAGT ATTCCTTGTT TGCTGTGGTT AATCACCAAG GAACCTTGGA GAGTGGCCAC 
TATACCAGCT TCATCCGGCA CCACAAGGAC CAGTGGTTCA AGTGTGATGA TGCCGTCATC 
ACTAAGGCCA GTATTAAGGA CGTACTGGAC AGTGAAGGGT ATTTACTGTT CTATCACAAA 
CAGGTGCTAG AACATGAGTC AGAAAAAGTG AAAGAAATGA ACACACAAGC CTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TGFβ-Activated USP27X Deubiquitinase Regulates Cell Migration and Chemoresistance via Stabilization of Snail1.
Cancer research79(1)33-46(2019 01)
Lambies G,Miceli M,Martínez-Guillamon C,Olivera-Salguero R,Peña R,Frías CP,Calderón I,Atanassov BS,Dent SYR,Arribas J,García de Herreros A,Díaz VM

USP27-mediated Cyclin E stabilization drives cell cycle progression and hepatocellular tumorigenesis.
Oncogene37(20)2702-2713(2018 05)
Dong L,Yu L,Bai C,Liu L,Long H,Shi L,Lin Z

The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis.
EMBO reports17(5)724-38(2016 05)
Weber A,Heinlein M,Dengjel J,Alber C,Singh PK,Häcker G

ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth.
Molecular cell62(4)558-71(2016 05)
Atanassov BS,Mohan RD,Lan X,Kuang X,Lu Y,Lin K,McIvor E,Li W,Zhang Y,Florens L,Byrum SD,Mackintosh SG,Calhoun-Davis T,Koutelou E,Wang L,Tang DG,Tackett AJ,Washburn MP,Workman JL,Dent SY

X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes.
Molecular psychiatry21(1)133-48(2016 Jan)
Hu H,Haas SA,Chelly J,Van Esch H,Raynaud M,de Brouwer AP,Weinert S,Froyen G,Frints SG,Laumonnier F,Zemojtel T,Love MI,Richard H,Emde AK,Bienek M,Jensen C,Hambrock M,Fischer U,Langnick C,Feldkamp M,Wissink-Lindhout W,Lebrun N,Castelnau L,Rucci J,Montjean R,Dorseuil O,Billuart P,Stuhlmann T,Shaw M,Corbett MA,Gardner A,Willis-Owen S,Tan C,Friend KL,Belet S,van Roozendaal KE,Jimenez-Pocquet M,Moizard MP,Ronce N,Sun R,O'Keeffe S,Chenna R,van Bömmel A,Göke J,Hackett A,Field M,Christie L,Boyle J,Haan E,Nelson J,Turner G,Baynam G,Gillessen-Kaesbach G,Müller U,Steinberger D,Budny B,Badura-Stronka M,Latos-Bieleńska A,Ousager LB,Wieacker P,Rodríguez Criado G,Bondeson ML,Annerén G,Dufke A,Cohen M,Van Maldergem L,Vincent-Delorme C,Echenne B,Simon-Bouy B,Kleefstra T,Willemsen M,Fryns JP,Devriendt K,Ullmann R,Vingron M,Wrogemann K,Wienker TF,Tzschach A,van Bokhoven H,Gecz J,Jentsch TJ,Chen W,Ropers HH,Kalscheuer VM

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USP27X cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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