IL1B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IL1B
Entrez Gene ID	3553
Full Name	interleukin 1 beta
Synonyms	IL-1,IL1-BETA,IL1F2
General protein information	Preferred Names interleukin 1 beta Names interleukin-1 beta IL-1 beta catabolin preinterleukin 1 beta pro-interleukin-1-beta
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q14.1
Summary	The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008].
Disorder MIM:	147720
Disorder Html:	{Gastric cancer risk after H. pylori infection}, 137215 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_017003988.2	XP_016859477.1	interleukin-1 beta isoform X1
NM_000576.3	NP_000567.1	interleukin-1 beta proprotein
NM_000576.2	NP_000567.1	interleukin-1 beta proprotein
XM_017003988.1	XP_016859477.1	interleukin-1 beta isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	IL1B	NP_000567.1
Canis lupus familiaris (dog)	IL1B	NP_001033060.1
Mus musculus (house mouse)	Il1b	NP_032387.1
Bos taurus (cattle)	IL1B	NP_776518.1
Rattus norvegicus (Norway rat)	Il1b	NP_113700.2
Macaca mulatta (Rhesus monkey)	IL1B	NP_001036221.1
Pan troglodytes (chimpanzee)	IL1B	XP_001147075.1
Xenopus tropicalis (tropical clawed frog)	il1b	XP_002932618.1

Gene Ontology
Bibliography

Related articles in PubMed

LncRNA MALAT1/MiR-145 Adjusts IL-1β-Induced Chondrocytes Viability and Cartilage Matrix Degradation by Regulating ADAMTS5 in Human Osteoarthritis.
Liu C, Ren S, Zhao S, Wang Y
Yonsei medical journal60(11)1081-1092(2019 Nov)

Polymorphism of the IL-1β, TNF, IL-1RA and IL-4 Cytokine Genes Significantly Increases the Risk of Preterm Birth.
Belousova VS, Svitich OA, Timokhina EV, Strizhakov AN, Bogomazova IM
Biochemistry. Biokhimiia84(9)1040-1046(2019 Sep)

Cancer-associated fibroblast-derived interleukin-1β activates protumor C-C motif chemokine ligand 22 signaling in head and neck cancer.
Huang YH, Chang CY, Kuo YZ, Fang WY, Kao HY, Tsai ST, Wu LW
Cancer science110(9)2783-2793(2019 Sep)

EVALUATION OF GENE POLYMORPHISM OF IL-1Β AND IL-10 IN CHILDREN WITH NEPHROTIC SYNDROME.
Dudnyk V, Zvenigorodska G, Zborovska O, Vyzhga I, Moskaliuk O
Georgian medical news(294)68-71(2019 Sep)

Polymorphisms in interleukin genes and their association with the risk of recurrent pregnancy loss.
Wang T, Lu N, Cui Y, Tian L
Genes & genetic systems94(3)109-116(2019 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following IL1B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL1B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25334	NM_000576.3 Latest version!	Homo sapiens interleukin 1 beta (IL1B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu89368	XM_017003988.2 Latest version!	Homo sapiens interleukin 1 beta (IL1B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu25334	NM_000576.2	Homo sapiens interleukin 1 beta (IL1B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu89368	XM_017003988.1	Homo sapiens interleukin 1 beta (IL1B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IL1B ( NM_000576.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000567.1 Homo sapiens interleukin 1 beta (IL1B), mRNA.

Price & Availability↑

CloneID	OHu25334
Clone ID Related Accession (Same CDS sequence)	NM_000576.3 , NM_000576.2
Accession Version	NM_000576.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577808000000
Organism	Homo sapiens(human)
Product	interleukin-1 beta proprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC079753.7. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_000576.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.109183.1, SRR5189652.136888.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000263341.7/ ENSP00000263341.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGCAGAAG TACCTGAGCT CGCCAGTGAA ATGATGGCTT ATTACAGTGG CAATGAGGAT 
GACTTGTTCT TTGAAGCTGA TGGCCCTAAA CAGATGAAGT GCTCCTTCCA GGACCTGGAC 
CTCTGCCCTC TGGATGGCGG CATCCAGCTA CGAATCTCCG ACCACCACTA CAGCAAGGGC 
TTCAGGCAGG CCGCGTCAGT TGTTGTGGCC ATGGACAAGC TGAGGAAGAT GCTGGTTCCC 
TGCCCACAGA CCTTCCAGGA GAATGACCTG AGCACCTTCT TTCCCTTCAT CTTTGAAGAA 
GAACCTATCT TCTTCGACAC ATGGGATAAC GAGGCTTATG TGCACGATGC ACCTGTACGA 
TCACTGAACT GCACGCTCCG GGACTCACAG CAAAAAAGCT TGGTGATGTC TGGTCCATAT 
GAACTGAAAG CTCTCCACCT CCAGGGACAG GATATGGAGC AACAAGTGGT GTTCTCCATG 
TCCTTTGTAC AAGGAGAAGA AAGTAATGAC AAAATACCTG TGGCCTTGGG CCTCAAGGAA 
AAGAATCTGT ACCTGTCCTG CGTGTTGAAA GATGATAAGC CCACTCTACA GCTGGAGAGT 
GTAGATCCCA AAAATTACCC AAAGAAGAAG ATGGAAAAGC GATTTGTCTT CAACAAGATA 
GAAATCAATA ACAAGCTGGA ATTTGAGTCT GCCCAGTTCC CCAACTGGTA CATCAGCACC 
TCTCAAGCAG AAAACATGCC CGTCTTCCTG GGAGGGACCA AAGGCGGCCA GGATATAACT 
GACTTCACCA TGCAATTTGT GTCTTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000567.1
CDS	88..897
Translation	MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKGFRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS

Target ORF information:

RefSeq Version	NM_000576.3
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 1 beta (IL1B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000576.3

ORF Insert Sequence:

ATGGCAGAAG TACCTGAGCT CGCCAGTGAA ATGATGGCTT ATTACAGTGG CAATGAGGAT 
GACTTGTTCT TTGAAGCTGA TGGCCCTAAA CAGATGAAGT GCTCCTTCCA GGACCTGGAC 
CTCTGCCCTC TGGATGGCGG CATCCAGCTA CGAATCTCCG ACCACCACTA CAGCAAGGGC 
TTCAGGCAGG CCGCGTCAGT TGTTGTGGCC ATGGACAAGC TGAGGAAGAT GCTGGTTCCC 
TGCCCACAGA CCTTCCAGGA GAATGACCTG AGCACCTTCT TTCCCTTCAT CTTTGAAGAA 
GAACCTATCT TCTTCGACAC ATGGGATAAC GAGGCTTATG TGCACGATGC ACCTGTACGA 
TCACTGAACT GCACGCTCCG GGACTCACAG CAAAAAAGCT TGGTGATGTC TGGTCCATAT 
GAACTGAAAG CTCTCCACCT CCAGGGACAG GATATGGAGC AACAAGTGGT GTTCTCCATG 
TCCTTTGTAC AAGGAGAAGA AAGTAATGAC AAAATACCTG TGGCCTTGGG CCTCAAGGAA 
AAGAATCTGT ACCTGTCCTG CGTGTTGAAA GATGATAAGC CCACTCTACA GCTGGAGAGT 
GTAGATCCCA AAAATTACCC AAAGAAGAAG ATGGAAAAGC GATTTGTCTT CAACAAGATA 
GAAATCAATA ACAAGCTGGA ATTTGAGTCT GCCCAGTTCC CCAACTGGTA CATCAGCACC 
TCTCAAGCAG AAAACATGCC CGTCTTCCTG GGAGGGACCA AAGGCGGCCA GGATATAACT 
GACTTCACCA TGCAATTTGT GTCTTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL1B ( NM_000576.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000567.1 Homo sapiens interleukin 1 beta (IL1B), mRNA.

Price & Availability↑

CloneID	OHu25334
Clone ID Related Accession (Same CDS sequence)	NM_000576.3 , NM_000576.2
Accession Version	NM_000576.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1547222400000
Organism	Homo sapiens(human)
Product	interleukin-1 beta proprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M15330.1. This sequence is a reference standard in the RefSeqGene project. On Jan 24, 2003 this sequence version replaced NM_000576.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC008678.1, K02770.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGCAGAAG TACCTGAGCT CGCCAGTGAA ATGATGGCTT ATTACAGTGG CAATGAGGAT 
GACTTGTTCT TTGAAGCTGA TGGCCCTAAA CAGATGAAGT GCTCCTTCCA GGACCTGGAC 
CTCTGCCCTC TGGATGGCGG CATCCAGCTA CGAATCTCCG ACCACCACTA CAGCAAGGGC 
TTCAGGCAGG CCGCGTCAGT TGTTGTGGCC ATGGACAAGC TGAGGAAGAT GCTGGTTCCC 
TGCCCACAGA CCTTCCAGGA GAATGACCTG AGCACCTTCT TTCCCTTCAT CTTTGAAGAA 
GAACCTATCT TCTTCGACAC ATGGGATAAC GAGGCTTATG TGCACGATGC ACCTGTACGA 
TCACTGAACT GCACGCTCCG GGACTCACAG CAAAAAAGCT TGGTGATGTC TGGTCCATAT 
GAACTGAAAG CTCTCCACCT CCAGGGACAG GATATGGAGC AACAAGTGGT GTTCTCCATG 
TCCTTTGTAC AAGGAGAAGA AAGTAATGAC AAAATACCTG TGGCCTTGGG CCTCAAGGAA 
AAGAATCTGT ACCTGTCCTG CGTGTTGAAA GATGATAAGC CCACTCTACA GCTGGAGAGT 
GTAGATCCCA AAAATTACCC AAAGAAGAAG ATGGAAAAGC GATTTGTCTT CAACAAGATA 
GAAATCAATA ACAAGCTGGA ATTTGAGTCT GCCCAGTTCC CCAACTGGTA CATCAGCACC 
TCTCAAGCAG AAAACATGCC CGTCTTCCTG GGAGGGACCA AAGGCGGCCA GGATATAACT 
GACTTCACCA TGCAATTTGT GTCTTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000567.1
CDS	88..897
Translation	MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKGFRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS

Target ORF information:

RefSeq Version	NM_000576.2
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 1 beta (IL1B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000576.2

ORF Insert Sequence:

ATGGCAGAAG TACCTGAGCT CGCCAGTGAA ATGATGGCTT ATTACAGTGG CAATGAGGAT 
GACTTGTTCT TTGAAGCTGA TGGCCCTAAA CAGATGAAGT GCTCCTTCCA GGACCTGGAC 
CTCTGCCCTC TGGATGGCGG CATCCAGCTA CGAATCTCCG ACCACCACTA CAGCAAGGGC 
TTCAGGCAGG CCGCGTCAGT TGTTGTGGCC ATGGACAAGC TGAGGAAGAT GCTGGTTCCC 
TGCCCACAGA CCTTCCAGGA GAATGACCTG AGCACCTTCT TTCCCTTCAT CTTTGAAGAA 
GAACCTATCT TCTTCGACAC ATGGGATAAC GAGGCTTATG TGCACGATGC ACCTGTACGA 
TCACTGAACT GCACGCTCCG GGACTCACAG CAAAAAAGCT TGGTGATGTC TGGTCCATAT 
GAACTGAAAG CTCTCCACCT CCAGGGACAG GATATGGAGC AACAAGTGGT GTTCTCCATG 
TCCTTTGTAC AAGGAGAAGA AAGTAATGAC AAAATACCTG TGGCCTTGGG CCTCAAGGAA 
AAGAATCTGT ACCTGTCCTG CGTGTTGAAA GATGATAAGC CCACTCTACA GCTGGAGAGT 
GTAGATCCCA AAAATTACCC AAAGAAGAAG ATGGAAAAGC GATTTGTCTT CAACAAGATA 
GAAATCAATA ACAAGCTGGA ATTTGAGTCT GCCCAGTTCC CCAACTGGTA CATCAGCACC 
TCTCAAGCAG AAAACATGCC CGTCTTCCTG GGAGGGACCA AAGGCGGCCA GGATATAACT 
GACTTCACCA TGCAATTTGT GTCTTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL1B ( XM_017003988.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016859477.1 Homo sapiens interleukin 1 beta (IL1B), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu89368
Clone ID Related Accession (Same CDS sequence)	XM_017003988.2 , XM_017003988.1
Accession Version	XM_017003988.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	interleukin-1 beta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017003988.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGTGCT CCTTCCAGGA CCTGGACCTC TGCCCTCTGG ATGGCGGCAT CCAGCTACGA 
ATCTCCGACC ACCACTACAG CAAGGGCTTC AGGCAGGCCG CGTCAGTTGT TGTGGCCATG 
GACAAGCTGA GGAAGATGCT GGTTCCCTGC CCACAGACCT TCCAGGAGAA TGACCTGAGC 
ACCTTCTTTC CCTTCATCTT TGAAGAAGAA CCTATCTTCT TCGACACATG GGATAACGAG 
GCTTATGTGC ACGATGCACC TGTACGATCA CTGAACTGCA CGCTCCGGGA CTCACAGCAA 
AAAAGCTTGG TGATGTCTGG TCCATATGAA CTGAAAGCTC TCCACCTCCA GGGACAGGAT 
ATGGAGCAAC AAGTGGTGTT CTCCATGTCC TTTGTACAAG GAGAAGAAAG TAATGACAAA 
ATACCTGTGG CCTTGGGCCT CAAGGAAAAG AATCTGTACC TGTCCTGCGT GTTGAAAGAT 
GATAAGCCCA CTCTACAGCT GGAGAGTGTA GATCCCAAAA ATTACCCAAA GAAGAAGATG 
GAAAAGCGAT TTGTCTTCAA CAAGATAGAA ATCAATAACA AGCTGGAATT TGAGTCTGCC 
CAGTTCCCCA ACTGGTACAT CAGCACCTCT CAAGCAGAAA ACATGCCCGT CTTCCTGGGA 
GGGACCAAAG GCGGCCAGGA TATAACTGAC TTCACCATGC AATTTGTGTC TTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016859477.1
CDS	183..899
Translation	MKCSFQDLDLCPLDGGIQLRISDHHYSKGFRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS

Target ORF information:

RefSeq Version	XM_017003988.2
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 1 beta (IL1B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017003988.2

ORF Insert Sequence:

ATGAAGTGCT CCTTCCAGGA CCTGGACCTC TGCCCTCTGG ATGGCGGCAT CCAGCTACGA 
ATCTCCGACC ACCACTACAG CAAGGGCTTC AGGCAGGCCG CGTCAGTTGT TGTGGCCATG 
GACAAGCTGA GGAAGATGCT GGTTCCCTGC CCACAGACCT TCCAGGAGAA TGACCTGAGC 
ACCTTCTTTC CCTTCATCTT TGAAGAAGAA CCTATCTTCT TCGACACATG GGATAACGAG 
GCTTATGTGC ACGATGCACC TGTACGATCA CTGAACTGCA CGCTCCGGGA CTCACAGCAA 
AAAAGCTTGG TGATGTCTGG TCCATATGAA CTGAAAGCTC TCCACCTCCA GGGACAGGAT 
ATGGAGCAAC AAGTGGTGTT CTCCATGTCC TTTGTACAAG GAGAAGAAAG TAATGACAAA 
ATACCTGTGG CCTTGGGCCT CAAGGAAAAG AATCTGTACC TGTCCTGCGT GTTGAAAGAT 
GATAAGCCCA CTCTACAGCT GGAGAGTGTA GATCCCAAAA ATTACCCAAA GAAGAAGATG 
GAAAAGCGAT TTGTCTTCAA CAAGATAGAA ATCAATAACA AGCTGGAATT TGAGTCTGCC 
CAGTTCCCCA ACTGGTACAT CAGCACCTCT CAAGCAGAAA ACATGCCCGT CTTCCTGGGA 
GGGACCAAAG GCGGCCAGGA TATAACTGAC TTCACCATGC AATTTGTGTC TTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL1B ( XM_017003988.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016859477.1 Homo sapiens interleukin 1 beta (IL1B), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu89368
Clone ID Related Accession (Same CDS sequence)	XM_017003988.2 , XM_017003988.1
Accession Version	XM_017003988.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1465056000000
Organism	Homo sapiens(human)
Product	interleukin-1 beta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGTGCT CCTTCCAGGA CCTGGACCTC TGCCCTCTGG ATGGCGGCAT CCAGCTACGA 
ATCTCCGACC ACCACTACAG CAAGGGCTTC AGGCAGGCCG CGTCAGTTGT TGTGGCCATG 
GACAAGCTGA GGAAGATGCT GGTTCCCTGC CCACAGACCT TCCAGGAGAA TGACCTGAGC 
ACCTTCTTTC CCTTCATCTT TGAAGAAGAA CCTATCTTCT TCGACACATG GGATAACGAG 
GCTTATGTGC ACGATGCACC TGTACGATCA CTGAACTGCA CGCTCCGGGA CTCACAGCAA 
AAAAGCTTGG TGATGTCTGG TCCATATGAA CTGAAAGCTC TCCACCTCCA GGGACAGGAT 
ATGGAGCAAC AAGTGGTGTT CTCCATGTCC TTTGTACAAG GAGAAGAAAG TAATGACAAA 
ATACCTGTGG CCTTGGGCCT CAAGGAAAAG AATCTGTACC TGTCCTGCGT GTTGAAAGAT 
GATAAGCCCA CTCTACAGCT GGAGAGTGTA GATCCCAAAA ATTACCCAAA GAAGAAGATG 
GAAAAGCGAT TTGTCTTCAA CAAGATAGAA ATCAATAACA AGCTGGAATT TGAGTCTGCC 
CAGTTCCCCA ACTGGTACAT CAGCACCTCT CAAGCAGAAA ACATGCCCGT CTTCCTGGGA 
GGGACCAAAG GCGGCCAGGA TATAACTGAC TTCACCATGC AATTTGTGTC TTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016859477.1
CDS	182..898
Translation	MKCSFQDLDLCPLDGGIQLRISDHHYSKGFRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS

Target ORF information:

RefSeq Version	XM_017003988.1
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 1 beta (IL1B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017003988.1

ORF Insert Sequence:

ATGAAGTGCT CCTTCCAGGA CCTGGACCTC TGCCCTCTGG ATGGCGGCAT CCAGCTACGA 
ATCTCCGACC ACCACTACAG CAAGGGCTTC AGGCAGGCCG CGTCAGTTGT TGTGGCCATG 
GACAAGCTGA GGAAGATGCT GGTTCCCTGC CCACAGACCT TCCAGGAGAA TGACCTGAGC 
ACCTTCTTTC CCTTCATCTT TGAAGAAGAA CCTATCTTCT TCGACACATG GGATAACGAG 
GCTTATGTGC ACGATGCACC TGTACGATCA CTGAACTGCA CGCTCCGGGA CTCACAGCAA 
AAAAGCTTGG TGATGTCTGG TCCATATGAA CTGAAAGCTC TCCACCTCCA GGGACAGGAT 
ATGGAGCAAC AAGTGGTGTT CTCCATGTCC TTTGTACAAG GAGAAGAAAG TAATGACAAA 
ATACCTGTGG CCTTGGGCCT CAAGGAAAAG AATCTGTACC TGTCCTGCGT GTTGAAAGAT 
GATAAGCCCA CTCTACAGCT GGAGAGTGTA GATCCCAAAA ATTACCCAAA GAAGAAGATG 
GAAAAGCGAT TTGTCTTCAA CAAGATAGAA ATCAATAACA AGCTGGAATT TGAGTCTGCC 
CAGTTCCCCA ACTGGTACAT CAGCACCTCT CAAGCAGAAA ACATGCCCGT CTTCCTGGGA 
GGGACCAAAG GCGGCCAGGA TATAACTGAC TTCACCATGC AATTTGTGTC TTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

LncRNA MALAT1/MiR-145 Adjusts IL-1β-Induced Chondrocytes Viability and Cartilage Matrix Degradation by Regulating ADAMTS5 in Human Osteoarthritis.
Yonsei medical journal60(11)1081-1092(2019 Nov)
Liu C,Ren S,Zhao S,Wang Y

Polymorphism of the IL-1β, TNF, IL-1RA and IL-4 Cytokine Genes Significantly Increases the Risk of Preterm Birth.
Biochemistry. Biokhimiia84(9)1040-1046(2019 Sep)
Belousova VS,Svitich OA,Timokhina EV,Strizhakov AN,Bogomazova IM

Cancer-associated fibroblast-derived interleukin-1β activates protumor C-C motif chemokine ligand 22 signaling in head and neck cancer.
Cancer science110(9)2783-2793(2019 Sep)
Huang YH,Chang CY,Kuo YZ,Fang WY,Kao HY,Tsai ST,Wu LW

EVALUATION OF GENE POLYMORPHISM OF IL-1Β AND IL-10 IN CHILDREN WITH NEPHROTIC SYNDROME.
Georgian medical news(294)68-71(2019 Sep)
Dudnyk V,Zvenigorodska G,Zborovska O,Vyzhga I,Moskaliuk O

Polymorphisms in interleukin genes and their association with the risk of recurrent pregnancy loss.
Genes & genetic systems94(3)109-116(2019 Jul)
Wang T,Lu N,Cui Y,Tian L

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