| Gene Symbol | HSPE1 |
| Entrez Gene ID | 3336 |
| Full Name | heat shock protein family E (Hsp10) member 1 |
| Synonyms | CPN10,EPF,GROES,HSP10 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011]. |
| Disorder MIM: |
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HSPE1 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following HSPE1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HSPE1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu17870 Clone ID Related Accession (Same CDS sequence) NM_002157.3 , NM_002157.2 Accession Version NM_002157.3 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 309bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1566316800000 Organism Homo sapiens(human) Product 10 kDa heat shock protein, mitochondrial Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC023518.2 and BG188453.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_002157.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.102397.1, SRR1163655.433354.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology MANE Ensembl match :: ENST00000233893.10/ ENSP00000233893.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301ATGGCAGGAC AAGCGTTTAG AAAGTTTCTT CCACTCTTTG ACCGAGTATT GGTTGAAAGG
AGTGCTGCTG AAACTGTAAC CAAAGGAGGC ATTATGCTTC CAGAAAAATC TCAAGGAAAA
GTATTGCAAG CAACAGTAGT CGCTGTTGGA TCGGGTTCTA AAGGAAAGGG TGGAGAGATT
CAACCAGTTA GCGTGAAAGT TGGAGATAAA GTTCTTCTCC CAGAATATGG AGGCACCAAA
GTAGTTCTAG ATGACAAGGA TTATTTCCTA TTTAGAGATG GTGACATTCT TGGAAAGTAC
GTAGACTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_002148.1 CDS 59..367 Translation 
Target ORF information:
RefSeq Version NM_002157.3 Organism Homo sapiens(human) Definition Homo sapiens heat shock protein family E (Hsp10) member 1 (HSPE1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_002157.3
ORF Insert Sequence:
1
61
121
181
241
301ATGGCAGGAC AAGCGTTTAG AAAGTTTCTT CCACTCTTTG ACCGAGTATT GGTTGAAAGG
AGTGCTGCTG AAACTGTAAC CAAAGGAGGC ATTATGCTTC CAGAAAAATC TCAAGGAAAA
GTATTGCAAG CAACAGTAGT CGCTGTTGGA TCGGGTTCTA AAGGAAAGGG TGGAGAGATT
CAACCAGTTA GCGTGAAAGT TGGAGATAAA GTTCTTCTCC CAGAATATGG AGGCACCAAA
GTAGTTCTAG ATGACAAGGA TTATTTCCTA TTTAGAGATG GTGACATTCT TGGAAAGTAC
GTAGACTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu17870 Clone ID Related Accession (Same CDS sequence) NM_002157.3 , NM_002157.2 Accession Version NM_002157.2 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 309bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1511712000000 Organism Homo sapiens(human) Product 10 kDa heat shock protein, mitochondrial Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN264788.1, BC023518.2 and BG188453.1. This sequence is a reference standard in the RefSeqGene project. On Oct 17, 2008 this sequence version replaced NM_002157.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.510550.1, SRR1660805.359481.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301ATGGCAGGAC AAGCGTTTAG AAAGTTTCTT CCACTCTTTG ACCGAGTATT GGTTGAAAGG
AGTGCTGCTG AAACTGTAAC CAAAGGAGGC ATTATGCTTC CAGAAAAATC TCAAGGAAAA
GTATTGCAAG CAACAGTAGT CGCTGTTGGA TCGGGTTCTA AAGGAAAGGG TGGAGAGATT
CAACCAGTTA GCGTGAAAGT TGGAGATAAA GTTCTTCTCC CAGAATATGG AGGCACCAAA
GTAGTTCTAG ATGACAAGGA TTATTTCCTA TTTAGAGATG GTGACATTCT TGGAAAGTAC
GTAGACTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_002148.1 CDS 441..749 Translation
Target ORF information:
RefSeq Version NM_002157.2 Organism Homo sapiens(human) Definition Homo sapiens heat shock protein family E (Hsp10) member 1 (HSPE1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_002157.2
ORF Insert Sequence:
1
61
121
181
241
301ATGGCAGGAC AAGCGTTTAG AAAGTTTCTT CCACTCTTTG ACCGAGTATT GGTTGAAAGG
AGTGCTGCTG AAACTGTAAC CAAAGGAGGC ATTATGCTTC CAGAAAAATC TCAAGGAAAA
GTATTGCAAG CAACAGTAGT CGCTGTTGGA TCGGGTTCTA AAGGAAAGGG TGGAGAGATT
CAACCAGTTA GCGTGAAAGT TGGAGATAAA GTTCTTCTCC CAGAATATGG AGGCACCAAA
GTAGTTCTAG ATGACAAGGA TTATTTCCTA TTTAGAGATG GTGACATTCT TGGAAAGTAC
GTAGACTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
High expression of heat shock protein 10 correlates negatively with estrogen/progesterone receptor status and predicts poor prognosis in invasive ductal breast carcinoma.
Human pathology61173-180(2017 03)
Chu S,Wen Q,Qing Z,Luo J,Wang W,Chen L,Feng J,Xu L,Zang H,Fan S
Elevated expression of HSP10 protein inhibits apoptosis and associates with poor prognosis of astrocytoma.
PloS one12(10)e0185563(2017)
Fan W,Fan SS,Feng J,Xiao D,Fan S,Luo J
miR-146a, miR-146b, and miR-155 increase expression of IL-6 and IL-8 and support HSP10 in an In vitro sepsis model.
PloS one12(6)e0179850(2017)
Pfeiffer D,Roßmanith E,Lang I,Falkenhagen D
Early Pregnancy Factor Enhances the Generation and Function of CD4
The Tohoku journal of experimental medicine240(3)215-220(2016 11)
Chen Q,Zhu X,Chen R,Liu J,Liu P,Hu A,Wu L,Hua H,Yuan H
Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter.
Human genetics112(1)71-7(2003 Jan)
Hansen JJ,Bross P,Westergaard M,Nielsen MN,Eiberg H,Børglum AD,Mogensen J,Kristiansen K,Bolund L,Gregersen N
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