PIK3R4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PIK3R4
Entrez Gene ID	30849
Full Name	phosphoinositide-3-kinase regulatory subunit 4
Synonyms	VPS15,p150
General protein information	Preferred Names phosphoinositide-3-kinase regulatory subunit 4 Names phosphoinositide 3-kinase regulatory subunit 4 PI3-kinase p150 subunit PI3-kinase regulatory subunit 4 phosphatidylinositol 3-kinase-associated p150 phosphoinositide 3-kinase adaptor protein phosphoinositide-3-kinase, regulatory subunit 4, p150
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q22.1
Disorder MIM:	602610

mRNA and Protein(s)

mRNA	Protein	Name
NM_014602.2	NP_055417.1	phosphoinositide 3-kinase regulatory subunit 4
NM_014602.3	NP_055417.1	phosphoinositide 3-kinase regulatory subunit 4

Pathways from BioSystems

Homologies

Oryza sativa (rice)	Os02g0796700	NP_001048391.1
Gallus gallus (chicken)	PIK3R4	XP_004939498.1
Danio rerio (zebrafish)	pik3r4	XP_001922676.1
Magnaporthe oryzae (rice blast fungus)	MGG_06100	XP_003711966.1
Eremothecium gossypii	AGOS_ADL316C	NP_983780.2
Neurospora crassa	NCU06626	XP_962368.2
Canis lupus familiaris (dog)	PIK3R4	XP_534260.1
Bos taurus (cattle)	PIK3R4	NP_001093784.1
Schizosaccharomyces pombe (fission yeast)	ppk19	NP_595288.1
Macaca mulatta (Rhesus monkey)	PIK3R4	XP_002802990.1
Mus musculus (house mouse)	Pik3r4	NP_001074778.1
Rattus norvegicus (Norway rat)	Pik3r4	NP_001102247.1
Saccharomyces cerevisiae (baker's yeast)	VPS15	NP_009655.2
Xenopus tropicalis (tropical clawed frog)	pik3r4	NP_001107701.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000602	XP_310476.5
Pan troglodytes (chimpanzee)	PIK3R4	XP_516746.2
Drosophila melanogaster (fruit fly)	ird1	NP_649868.1
Arabidopsis thaliana (thale cress)	AT4G29380	NP_194667.1
Kluyveromyces lactis	KLLA0B11924g	XP_452060.1
Homo sapiens (human)	PIK3R4	NP_055417.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.
Gstrein T, Edwards A, Přistoupilová A, Leca I, Breuss M, Pilat-Carotta S, Hansen AH, Tripathy R, Traunbauer AK, Hochstoeger T, Rosoklija G, Repic M, Landler L, Stránecký V, Dürnberger G, Keane TM, Zuber J, Adams DJ, Flint J, Honzik T, Gut M, Beltran S, Mechtler K, Sherr E, Kmoch S, Gut I, Keays DA
Nature neuroscience21(2)207-217(2018 02)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Autophagy dysregulation in Danon disease.
Nascimbeni AC, Fanin M, Angelini C, Sandri M
Cell death & disease8(1)e2565(2017 01)

A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi.
Stoetzel C, Bär S, De Craene JO, Scheidecker S, Etard C, Chicher J, Reck JR, Perrault I, Geoffroy V, Chennen K, Strähle U, Hammann P, Friant S, Dollfus H
Nature communications713586(2016 11)

High expression of PI3K core complex genes is associated with poor prognosis in chronic lymphocytic leukemia.
Kristensen L, Kristensen T, Abildgaard N, Thomassen M, Frederiksen M, Mourits-Andersen T, Møller MB
Leukemia research39(6)555-60(2015 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PIK3R4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PIK3R4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06559	NM_014602.3 Latest version!	Homo sapiens phosphoinositide-3-kinase regulatory subunit 4 (PIK3R4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$384.30 $549.00
View Old Accession Versions >>
OHu06559	NM_014602.2	Homo sapiens phosphoinositide-3-kinase regulatory subunit 4 (PIK3R4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$274.50-$384.30 $549.00
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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PIK3R4 ( NM_014602.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_055417.1 Homo sapiens phosphoinositide-3-kinase regulatory subunit 4 (PIK3R4), mRNA.

Price & Availability↑

CloneID	OHu06559
Clone ID Related Accession (Same CDS sequence)	NM_014602.2 , NM_014602.3
Accession Version	NM_014602.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4077bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1509465600000
Organism	Homo sapiens(human)
Product	phosphoinositide 3-kinase regulatory subunit 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP359657.1 and Y08991.1. On Oct 28, 2006 this sequence version replaced NM_014602.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y08991.1, SRR1803616.271117.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAAATC AGCTTGCTGG CATTGCTCCC TCCCAGATCC TTTCTGTAGA GAGTTATTTT 
TCAGATATTC ATGACTTTGA ATATGATAAA AGCCTGGGGA GTACTCGGTT TTTTAAAGTT 
GCTCGAGCCA AGCACCGAGA AGGCCTGGTC GTTGTGAAGG TTTTTGCAAT TCAGGATCCC 
ACATTGCCTT TAACCAGCTA TAAACAAGAG CTGGAGGAAC TGAAAATCAG GCTTAATTCT 
GCACAGAATT GTCTACCTTT CCAGAAAGCA TCAGAAAAAG CATCTGAGAA AGCAGCTATG 
CTCTTTAGGC AGTATGTGCG AGACAATCTC TATGATCGCA TCAGTACCCG TCCATTCTTG 
AATAACATTG AGAAGCGCTG GATTGCTTTC CAGATCCTGA CAGCTGTGGA CCAAGCACAC 
AAATCTGGAG TTCGTCATGG GGACATCAAG ACTGAGAATG TGATGGTCAC CAGTTGGAAT 
TGGGTTCTTC TAACTGATTT TGCCAGTTTT AAGCCCACTT ATCTTCCAGA AGACAACCCG 
GCAGATTTCA ATTATTTCTT TGACACATCA CGGAGGAGAA CTTGCTATAT TGCTCCTGAA 
CGTTTTGTTG ATGGTGGGAT GTTTGCCACT GAGTTAGAAT ATATGAGAGA TCCTTCAACT 
CCGCTTGTAG ACTTAAATAG CAATCAGAGA ACAAGAGGAG AGTTGAAGAG AGCAATGGAC 
ATCTTTTCAG CAGGTTGTGT GATAGCTGAG CTTTTTACAG AAGGTGTACC ATTATTTGAT 
CTCTCTCAAC TTTTGGCTTA TAGAAATGGA CATTTTTTCC CTGAACAAGT GCTAAATAAA 
ATTGAAGATC ACAGTATCAG AGAATTGGTA ACTCAGATGA TTCACCGTGA GCCAGATAAA 
CGTTTAGAGG CAGAAGATTA CTTAAAACAG CAGCGTGGCA ATGCCTTTCC TGAAATATTT 
TACACTTTTC TTCAGCCCTA CATGGCCCAG TTTGCCAAGG AAACGTTTCT TTCTGCAGAT 
GAGCGTATTC TGGTTATACG GAAGGATTTG GGCAACATTA TTCACAATCT CTGTGGACAT 
GATCTGCCAG AAAAAGCCGA AGGAGAGCCT AAGGAAAATG GGCTGGTTAT CTTGGTATCT 
GTTATAACAT CCTGCCTACA GACCCTTAAA TACTGTGATT CCAAACTAGC TGCTTTGGAA 
CTGATTCTTC ATTTGGCTCC AAGATTAAGT GTTGAAATCC TTTTGGATCG TATTACTCCA 
TATCTTTTGC ATTTCAGCAA TGACTCTGTT CCTAGGGTGA GGGCTGAAGC CTTGAGGACG 
TTGACCAAAG TTCTTGCTCT CGTCAAAGAG GTTCCTCGTA ATGATATCAA TATTTATCCG 
GAATACATTC TGCCAGGCAT AGCCCACTTA GCCCAAGATG ATGCTACTAT CGTTAGACTA 
GCCTATGCTG AAAACATAGC TCTGCTGGCA GAAACAGCTC TGAGATTCCT GGAATTAGTA 
CAGTTAAAAA ATCTTAATAT GGAAAATGAC CCCAATAATG AAGAAATAGA TGAGGTTACA 
CATCCAAATG GAAATTATGA CACAGAGCTC CAAGCCTTAC ATGAAATGGT CCAGCAGAAA 
GTTGTTACTT TGCTAAGTGA CCCTGAAAAT ATTGTAAAAC AAACCTTGAT GGAAAATGGA 
ATAACACGGC TGTGTGTATT CTTTGGACGT CAGAAAGCCA ACGATGTTTT GTTGTCCCAC 
ATGATTACTT TCCTAAATGA TAAGAATGAT TGGCATCTAC GTGGAGCATT TTTTGATAGT 
ATAGTTGGTG TTGCTGCCTA TGTTGGCTGG CAAAGCTCCT CAATTCTCAA GCCTCTGCTG 
CAACAAGGTC TTAGTGATGC TGAGGAATTT GTCATTGTGA AAGCTCTTTA TGCCCTTACT 
TGTATGTGCC AGTTAGGACT GCTACAAAAA CCCCATGTTT ACGAATTTGC CAGTGATATT 
GCCCCCTTCC TGTGTCATCC CAATTTATGG ATACGTTATG GTGCCGTGGG ATTTATCACA 
GTGGTAGCTC GTCAAATAAG TACAGCTGAT GTCTACTGTA AACTGATGCC TTATCTTGAC 
CCATATATTA CCCAACCAAT AATACAGATT GAAAGAAAAC TTGTTCTGCT CAGTGTTTTA 
AAGGAACCAG TAAGTCGTTC TATATTTGAT TATGCTTTGA GGTCTAAAGA TATTACTAGC 
TTGTTCAGAC ATCTTCACAT GCGTCAGAAG AAACGAAATG GTTCTCTTCC CGACTGCCCT 
CCGCCAGAGG ATCCTGCCAT AGCACAGCTT CTGAAGAAGT TGCTCTCACA GGGAATGACA 
GAGGAAGAGG AAGACAAACT TCTGGCACTG AAAGACTTCA TGATGAAATC TAATAAAGCA 
AAGGCCAATA TAGTGGACCA GAGCCATCTT CATGATAGTA GTCAGAAAGG TGTAATTGAC 
TTGGCAGCTT TAGGCATAAC TGGGAGACAA GTTGATCTTG TTAAAACCAA ACAAGAACCA 
GATGACAAAC GGGCCAGAAA ACATGTAAAA CAAGACTCAA ATGTAAATGA AGAATGGAAA 
AGCATGTTTG GGTCACTGGA CCCACCAAAC ATGCCACAGG CCCTACCTAA AGGGAGTGAT 
CAGGAGGTGA TTCAGACTGG GAAACCTCCT CGTTCCGAGT CCTCTGCTGG CATTTGTGTC 
CCTTTGTCAA CTTCTTCACA GGTTCCAGAA GTGACAACTG TCCAAAATAA AAAACCAGTA 
ATACCGGTTT TAAGTAGTAC AATCTTACCA TCCACCTATC AGATTCGAAT TACAACTTGT 
AAAACTGAAC TTCAGCAACT CATCCAGCAA AAGCGGGAGC AGTGCAATGC TGAGAGAATA 
GCTAAGCAGA TGATGGAAAA TGCTGAATGG GAGAGTAAAC CACCACCACC TGGATGGCGT 
CCTAAAGGGC TGTTAGTTGC CCATCTTCAT GAGCATAAAT CTGCTGTGAA TCGAATTAGA 
GTCTCTGATG AACACTCACT TTTTGCAACA TGTTCAAATG ATGGCACAGT GAAAATCTGG 
AACAGTCAAA AGATGGAGGG GAAGACCACC ACTACCAGAT CTATTCTTAC ATACAGCCGA 
ATTGGAGGAC GAGTCAAGAC GCTCACATTC TGCCAAGGCT CCCACTATTT AGCCATAGCA 
TCTGATAATG GTGCTGTCCA GCTTCTTGGA ATTGAGGCTT CTAAGCTGCC CAAGTCTCCT 
AAAATCCATC CTCTACAAAG CAGAATTCTA GATCAGAAGG AGGACGGTTG TGTTGTGGAT 
ATGCATCACT TCAACTCTGG AGCACAGTCT GTTCTTGCCT ATGCCACTGT GAATGGCTCT 
CTGGTTGGCT GGGACCTTAG GTCTTCAAGC AATGCGTGGA CTTTAAAGCA TGATTTAAAG 
TCGGGCCTCA TCACTTCCTT TGCTGTGGAC ATCCACCAAT GCTGGCTCTG CATTGGTACA 
AGCAGTGGTA CCATGGCTTG TTGGGACATG AGGTTCCAGT TGCCAATTTC AAGTCACTGT 
CATCCTTCCA GGGCTCGAAT CAGACGCCTC TCAATGCACC CTCTGTATCA GTCCTGGGTG 
ATTGCAGCTG TTCAGGGCAA CAACGAAGTG TCCATGTGGG ACATGGAGAC TGGTGACAGA 
AGATTTACTC TCTGGGCCAG CAGTGCACCA CCACTTTCTG AATTACAGCC TTCTCCTCAT 
AGCGTCCATG GTATCTACTG TAGTCCTGCA GATGGAAATC CTATCCTACT AACAGCTGGC 
TCAGATATGA AAATAAGGTT TTGGGACTTG GCTTACCCAG AAAGGTCCTA TGTTGTTGCA 
GGAAGTACTA GTTCCCCATC TGTGTCCTAC TACAGGAAAA TAATTGAAGG CACTGAAGTT 
GTCCAGGAAA TTCAGAATAA GCAGAAAGTA GGACCAAGTG ATGACACCCC TCGAAGGGGC 
CCAGAGTCCC TGCCCGTGGG ACATCATGAC ATCATCACTG ATGTCGCCAC ATTCCAGACC 
ACACAGGGCT TCATCGTAAC TGCTTCTAGA GATGGGATTG TGAAGGTGTG GAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055417.1
CDS	582..4658
Translation	MGNQLAGIAPSQILSVESYFSDIHDFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLNSAQNCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFFPEQVLNKIEDHSIRELVTQMIHREPDKRLEAEDYLKQQRGNAFPEIFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLCGHDLPEKAEGEPKENGLVILVSVITSCLQTLKYCDSKLAALELILHLAPRLSVEILLDRITPYLLHFSNDSVPRVRAEALRTLTKVLALVKEVPRNDINIYPEYILPGIAHLAQDDATIVRLAYAENIALLAETALRFLELVQLKNLNMENDPNNEEIDEVTHPNGNYDTELQALHEMVQQKVVTLLSDPENIVKQTLMENGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGVAAYVGWQSSSILKPLLQQGLSDAEEFVIVKALYALTCMCQLGLLQKPHVYEFASDIAPFLCHPNLWIRYGAVGFITVVARQISTADVYCKLMPYLDPYITQPIIQIERKLVLLSVLKEPVSRSIFDYALRSKDITSLFRHLHMRQKKRNGSLPDCPPPEDPAIAQLLKKLLSQGMTEEEEDKLLALKDFMMKSNKAKANIVDQSHLHDSSQKGVIDLAALGITGRQVDLVKTKQEPDDKRARKHVKQDSNVNEEWKSMFGSLDPPNMPQALPKGSDQEVIQTGKPPRSESSAGICVPLSTSSQVPEVTTVQNKKPVIPVLSSTILPSTYQIRITTCKTELQQLIQQKREQCNAERIAKQMMENAEWESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHSLFATCSNDGTVKIWNSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASKLPKSPKIHPLQSRILDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLKSGLITSFAVDIHQCWLCIGTSSGTMACWDMRFQLPISSHCHPSRARIRRLSMHPLYQSWVIAAVQGNNEVSMWDMETGDRRFTLWASSAPPLSELQPSPHSVHGIYCSPADGNPILLTAGSDMKIRFWDLAYPERSYVVAGSTSSPSVSYYRKIIEGTEVVQEIQNKQKVGPSDDTPRRGPESLPVGHHDIITDVATFQTTQGFIVTASRDGIVKVWK

Target ORF information:

RefSeq Version	NM_014602.2
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphoinositide-3-kinase regulatory subunit 4 (PIK3R4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014602.2

ORF Insert Sequence:

ATGGGAAATC AGCTTGCTGG CATTGCTCCC TCCCAGATCC TTTCTGTAGA GAGTTATTTT 
TCAGATATTC ATGACTTTGA ATATGATAAA AGCCTGGGGA GTACTCGGTT TTTTAAAGTT 
GCTCGAGCCA AGCACCGAGA AGGCCTGGTC GTTGTGAAGG TTTTTGCAAT TCAGGATCCC 
ACATTGCCTT TAACCAGCTA TAAACAAGAG CTGGAGGAAC TGAAAATCAG GCTTAATTCT 
GCACAGAATT GTCTACCTTT CCAGAAAGCA TCAGAAAAAG CATCTGAGAA AGCAGCTATG 
CTCTTTAGGC AGTATGTGCG AGACAATCTC TATGATCGCA TCAGTACCCG TCCATTCTTG 
AATAACATTG AGAAGCGCTG GATTGCTTTC CAGATCCTGA CAGCTGTGGA CCAAGCACAC 
AAATCTGGAG TTCGTCATGG GGACATCAAG ACTGAGAATG TGATGGTCAC CAGTTGGAAT 
TGGGTTCTTC TAACTGATTT TGCCAGTTTT AAGCCCACTT ATCTTCCAGA AGACAACCCG 
GCAGATTTCA ATTATTTCTT TGACACATCA CGGAGGAGAA CTTGCTATAT TGCTCCTGAA 
CGTTTTGTTG ATGGTGGGAT GTTTGCCACT GAGTTAGAAT ATATGAGAGA TCCTTCAACT 
CCGCTTGTAG ACTTAAATAG CAATCAGAGA ACAAGAGGAG AGTTGAAGAG AGCAATGGAC 
ATCTTTTCAG CAGGTTGTGT GATAGCTGAG CTTTTTACAG AAGGTGTACC ATTATTTGAT 
CTCTCTCAAC TTTTGGCTTA TAGAAATGGA CATTTTTTCC CTGAACAAGT GCTAAATAAA 
ATTGAAGATC ACAGTATCAG AGAATTGGTA ACTCAGATGA TTCACCGTGA GCCAGATAAA 
CGTTTAGAGG CAGAAGATTA CTTAAAACAG CAGCGTGGCA ATGCCTTTCC TGAAATATTT 
TACACTTTTC TTCAGCCCTA CATGGCCCAG TTTGCCAAGG AAACGTTTCT TTCTGCAGAT 
GAGCGTATTC TGGTTATACG GAAGGATTTG GGCAACATTA TTCACAATCT CTGTGGACAT 
GATCTGCCAG AAAAAGCCGA AGGAGAGCCT AAGGAAAATG GGCTGGTTAT CTTGGTATCT 
GTTATAACAT CCTGCCTACA GACCCTTAAA TACTGTGATT CCAAACTAGC TGCTTTGGAA 
CTGATTCTTC ATTTGGCTCC AAGATTAAGT GTTGAAATCC TTTTGGATCG TATTACTCCA 
TATCTTTTGC ATTTCAGCAA TGACTCTGTT CCTAGGGTGA GGGCTGAAGC CTTGAGGACG 
TTGACCAAAG TTCTTGCTCT CGTCAAAGAG GTTCCTCGTA ATGATATCAA TATTTATCCG 
GAATACATTC TGCCAGGCAT AGCCCACTTA GCCCAAGATG ATGCTACTAT CGTTAGACTA 
GCCTATGCTG AAAACATAGC TCTGCTGGCA GAAACAGCTC TGAGATTCCT GGAATTAGTA 
CAGTTAAAAA ATCTTAATAT GGAAAATGAC CCCAATAATG AAGAAATAGA TGAGGTTACA 
CATCCAAATG GAAATTATGA CACAGAGCTC CAAGCCTTAC ATGAAATGGT CCAGCAGAAA 
GTTGTTACTT TGCTAAGTGA CCCTGAAAAT ATTGTAAAAC AAACCTTGAT GGAAAATGGA 
ATAACACGGC TGTGTGTATT CTTTGGACGT CAGAAAGCCA ACGATGTTTT GTTGTCCCAC 
ATGATTACTT TCCTAAATGA TAAGAATGAT TGGCATCTAC GTGGAGCATT TTTTGATAGT 
ATAGTTGGTG TTGCTGCCTA TGTTGGCTGG CAAAGCTCCT CAATTCTCAA GCCTCTGCTG 
CAACAAGGTC TTAGTGATGC TGAGGAATTT GTCATTGTGA AAGCTCTTTA TGCCCTTACT 
TGTATGTGCC AGTTAGGACT GCTACAAAAA CCCCATGTTT ACGAATTTGC CAGTGATATT 
GCCCCCTTCC TGTGTCATCC CAATTTATGG ATACGTTATG GTGCCGTGGG ATTTATCACA 
GTGGTAGCTC GTCAAATAAG TACAGCTGAT GTCTACTGTA AACTGATGCC TTATCTTGAC 
CCATATATTA CCCAACCAAT AATACAGATT GAAAGAAAAC TTGTTCTGCT CAGTGTTTTA 
AAGGAACCAG TAAGTCGTTC TATATTTGAT TATGCTTTGA GGTCTAAAGA TATTACTAGC 
TTGTTCAGAC ATCTTCACAT GCGTCAGAAG AAACGAAATG GTTCTCTTCC CGACTGCCCT 
CCGCCAGAGG ATCCTGCCAT AGCACAGCTT CTGAAGAAGT TGCTCTCACA GGGAATGACA 
GAGGAAGAGG AAGACAAACT TCTGGCACTG AAAGACTTCA TGATGAAATC TAATAAAGCA 
AAGGCCAATA TAGTGGACCA GAGCCATCTT CATGATAGTA GTCAGAAAGG TGTAATTGAC 
TTGGCAGCTT TAGGCATAAC TGGGAGACAA GTTGATCTTG TTAAAACCAA ACAAGAACCA 
GATGACAAAC GGGCCAGAAA ACATGTAAAA CAAGACTCAA ATGTAAATGA AGAATGGAAA 
AGCATGTTTG GGTCACTGGA CCCACCAAAC ATGCCACAGG CCCTACCTAA AGGGAGTGAT 
CAGGAGGTGA TTCAGACTGG GAAACCTCCT CGTTCCGAGT CCTCTGCTGG CATTTGTGTC 
CCTTTGTCAA CTTCTTCACA GGTTCCAGAA GTGACAACTG TCCAAAATAA AAAACCAGTA 
ATACCGGTTT TAAGTAGTAC AATCTTACCA TCCACCTATC AGATTCGAAT TACAACTTGT 
AAAACTGAAC TTCAGCAACT CATCCAGCAA AAGCGGGAGC AGTGCAATGC TGAGAGAATA 
GCTAAGCAGA TGATGGAAAA TGCTGAATGG GAGAGTAAAC CACCACCACC TGGATGGCGT 
CCTAAAGGGC TGTTAGTTGC CCATCTTCAT GAGCATAAAT CTGCTGTGAA TCGAATTAGA 
GTCTCTGATG AACACTCACT TTTTGCAACA TGTTCAAATG ATGGCACAGT GAAAATCTGG 
AACAGTCAAA AGATGGAGGG GAAGACCACC ACTACCAGAT CTATTCTTAC ATACAGCCGA 
ATTGGAGGAC GAGTCAAGAC GCTCACATTC TGCCAAGGCT CCCACTATTT AGCCATAGCA 
TCTGATAATG GTGCTGTCCA GCTTCTTGGA ATTGAGGCTT CTAAGCTGCC CAAGTCTCCT 
AAAATCCATC CTCTACAAAG CAGAATTCTA GATCAGAAGG AGGACGGTTG TGTTGTGGAT 
ATGCATCACT TCAACTCTGG AGCACAGTCT GTTCTTGCCT ATGCCACTGT GAATGGCTCT 
CTGGTTGGCT GGGACCTTAG GTCTTCAAGC AATGCGTGGA CTTTAAAGCA TGATTTAAAG 
TCGGGCCTCA TCACTTCCTT TGCTGTGGAC ATCCACCAAT GCTGGCTCTG CATTGGTACA 
AGCAGTGGTA CCATGGCTTG TTGGGACATG AGGTTCCAGT TGCCAATTTC AAGTCACTGT 
CATCCTTCCA GGGCTCGAAT CAGACGCCTC TCAATGCACC CTCTGTATCA GTCCTGGGTG 
ATTGCAGCTG TTCAGGGCAA CAACGAAGTG TCCATGTGGG ACATGGAGAC TGGTGACAGA 
AGATTTACTC TCTGGGCCAG CAGTGCACCA CCACTTTCTG AATTACAGCC TTCTCCTCAT 
AGCGTCCATG GTATCTACTG TAGTCCTGCA GATGGAAATC CTATCCTACT AACAGCTGGC 
TCAGATATGA AAATAAGGTT TTGGGACTTG GCTTACCCAG AAAGGTCCTA TGTTGTTGCA 
GGAAGTACTA GTTCCCCATC TGTGTCCTAC TACAGGAAAA TAATTGAAGG CACTGAAGTT 
GTCCAGGAAA TTCAGAATAA GCAGAAAGTA GGACCAAGTG ATGACACCCC TCGAAGGGGC 
CCAGAGTCCC TGCCCGTGGG ACATCATGAC ATCATCACTG ATGTCGCCAC ATTCCAGACC 
ACACAGGGCT TCATCGTAAC TGCTTCTAGA GATGGGATTG TGAAGGTGTG GAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PIK3R4 ( NM_014602.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055417.1 Homo sapiens phosphoinositide-3-kinase regulatory subunit 4 (PIK3R4), mRNA.

Price & Availability↑

CloneID	OHu06559
Clone ID Related Accession (Same CDS sequence)	NM_014602.2 , NM_014602.3
Accession Version	NM_014602.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4077bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	phosphoinositide 3-kinase regulatory subunit 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP359657.1 and Y08991.1. On Nov 22, 2018 this sequence version replaced NM_014602.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y08991.1, SRR1803614.188243.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000356763.8/ ENSP00000349205.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGAAATC AGCTTGCTGG CATTGCTCCC TCCCAGATCC TTTCTGTAGA GAGTTATTTT 
TCAGATATTC ATGACTTTGA ATATGATAAA AGCCTGGGGA GTACTCGGTT TTTTAAAGTT 
GCTCGAGCCA AGCACCGAGA AGGCCTGGTC GTTGTGAAGG TTTTTGCAAT TCAGGATCCC 
ACATTGCCTT TAACCAGCTA TAAACAAGAG CTGGAGGAAC TGAAAATCAG GCTTAATTCT 
GCACAGAATT GTCTACCTTT CCAGAAAGCA TCAGAAAAAG CATCTGAGAA AGCAGCTATG 
CTCTTTAGGC AGTATGTGCG AGACAATCTC TATGATCGCA TCAGTACCCG TCCATTCTTG 
AATAACATTG AGAAGCGCTG GATTGCTTTC CAGATCCTGA CAGCTGTGGA CCAAGCACAC 
AAATCTGGAG TTCGTCATGG GGACATCAAG ACTGAGAATG TGATGGTCAC CAGTTGGAAT 
TGGGTTCTTC TAACTGATTT TGCCAGTTTT AAGCCCACTT ATCTTCCAGA AGACAACCCG 
GCAGATTTCA ATTATTTCTT TGACACATCA CGGAGGAGAA CTTGCTATAT TGCTCCTGAA 
CGTTTTGTTG ATGGTGGGAT GTTTGCCACT GAGTTAGAAT ATATGAGAGA TCCTTCAACT 
CCGCTTGTAG ACTTAAATAG CAATCAGAGA ACAAGAGGAG AGTTGAAGAG AGCAATGGAC 
ATCTTTTCAG CAGGTTGTGT GATAGCTGAG CTTTTTACAG AAGGTGTACC ATTATTTGAT 
CTCTCTCAAC TTTTGGCTTA TAGAAATGGA CATTTTTTCC CTGAACAAGT GCTAAATAAA 
ATTGAAGATC ACAGTATCAG AGAATTGGTA ACTCAGATGA TTCACCGTGA GCCAGATAAA 
CGTTTAGAGG CAGAAGATTA CTTAAAACAG CAGCGTGGCA ATGCCTTTCC TGAAATATTT 
TACACTTTTC TTCAGCCCTA CATGGCCCAG TTTGCCAAGG AAACGTTTCT TTCTGCAGAT 
GAGCGTATTC TGGTTATACG GAAGGATTTG GGCAACATTA TTCACAATCT CTGTGGACAT 
GATCTGCCAG AAAAAGCCGA AGGAGAGCCT AAGGAAAATG GGCTGGTTAT CTTGGTATCT 
GTTATAACAT CCTGCCTACA GACCCTTAAA TACTGTGATT CCAAACTAGC TGCTTTGGAA 
CTGATTCTTC ATTTGGCTCC AAGATTAAGT GTTGAAATCC TTTTGGATCG TATTACTCCA 
TATCTTTTGC ATTTCAGCAA TGACTCTGTT CCTAGGGTGA GGGCTGAAGC CTTGAGGACG 
TTGACCAAAG TTCTTGCTCT CGTCAAAGAG GTTCCTCGTA ATGATATCAA TATTTATCCG 
GAATACATTC TGCCAGGCAT AGCCCACTTA GCCCAAGATG ATGCTACTAT CGTTAGACTA 
GCCTATGCTG AAAACATAGC TCTGCTGGCA GAAACAGCTC TGAGATTCCT GGAATTAGTA 
CAGTTAAAAA ATCTTAATAT GGAAAATGAC CCCAATAATG AAGAAATAGA TGAGGTTACA 
CATCCAAATG GAAATTATGA CACAGAGCTC CAAGCCTTAC ATGAAATGGT CCAGCAGAAA 
GTTGTTACTT TGCTAAGTGA CCCTGAAAAT ATTGTAAAAC AAACCTTGAT GGAAAATGGA 
ATAACACGGC TGTGTGTATT CTTTGGACGT CAGAAAGCCA ACGATGTTTT GTTGTCCCAC 
ATGATTACTT TCCTAAATGA TAAGAATGAT TGGCATCTAC GTGGAGCATT TTTTGATAGT 
ATAGTTGGTG TTGCTGCCTA TGTTGGCTGG CAAAGCTCCT CAATTCTCAA GCCTCTGCTG 
CAACAAGGTC TTAGTGATGC TGAGGAATTT GTCATTGTGA AAGCTCTTTA TGCCCTTACT 
TGTATGTGCC AGTTAGGACT GCTACAAAAA CCCCATGTTT ACGAATTTGC CAGTGATATT 
GCCCCCTTCC TGTGTCATCC CAATTTATGG ATACGTTATG GTGCCGTGGG ATTTATCACA 
GTGGTAGCTC GTCAAATAAG TACAGCTGAT GTCTACTGTA AACTGATGCC TTATCTTGAC 
CCATATATTA CCCAACCAAT AATACAGATT GAAAGAAAAC TTGTTCTGCT CAGTGTTTTA 
AAGGAACCAG TAAGTCGTTC TATATTTGAT TATGCTTTGA GGTCTAAAGA TATTACTAGC 
TTGTTCAGAC ATCTTCACAT GCGTCAGAAG AAACGAAATG GTTCTCTTCC CGACTGCCCT 
CCGCCAGAGG ATCCTGCCAT AGCACAGCTT CTGAAGAAGT TGCTCTCACA GGGAATGACA 
GAGGAAGAGG AAGACAAACT TCTGGCACTG AAAGACTTCA TGATGAAATC TAATAAAGCA 
AAGGCCAATA TAGTGGACCA GAGCCATCTT CATGATAGTA GTCAGAAAGG TGTAATTGAC 
TTGGCAGCTT TAGGCATAAC TGGGAGACAA GTTGATCTTG TTAAAACCAA ACAAGAACCA 
GATGACAAAC GGGCCAGAAA ACATGTAAAA CAAGACTCAA ATGTAAATGA AGAATGGAAA 
AGCATGTTTG GGTCACTGGA CCCACCAAAC ATGCCACAGG CCCTACCTAA AGGGAGTGAT 
CAGGAGGTGA TTCAGACTGG GAAACCTCCT CGTTCCGAGT CCTCTGCTGG CATTTGTGTC 
CCTTTGTCAA CTTCTTCACA GGTTCCAGAA GTGACAACTG TCCAAAATAA AAAACCAGTA 
ATACCGGTTT TAAGTAGTAC AATCTTACCA TCCACCTATC AGATTCGAAT TACAACTTGT 
AAAACTGAAC TTCAGCAACT CATCCAGCAA AAGCGGGAGC AGTGCAATGC TGAGAGAATA 
GCTAAGCAGA TGATGGAAAA TGCTGAATGG GAGAGTAAAC CACCACCACC TGGATGGCGT 
CCTAAAGGGC TGTTAGTTGC CCATCTTCAT GAGCATAAAT CTGCTGTGAA TCGAATTAGA 
GTCTCTGATG AACACTCACT TTTTGCAACA TGTTCAAATG ATGGCACAGT GAAAATCTGG 
AACAGTCAAA AGATGGAGGG GAAGACCACC ACTACCAGAT CTATTCTTAC ATACAGCCGA 
ATTGGAGGAC GAGTCAAGAC GCTCACATTC TGCCAAGGCT CCCACTATTT AGCCATAGCA 
TCTGATAATG GTGCTGTCCA GCTTCTTGGA ATTGAGGCTT CTAAGCTGCC CAAGTCTCCT 
AAAATCCATC CTCTACAAAG CAGAATTCTA GATCAGAAGG AGGACGGTTG TGTTGTGGAT 
ATGCATCACT TCAACTCTGG AGCACAGTCT GTTCTTGCCT ATGCCACTGT GAATGGCTCT 
CTGGTTGGCT GGGACCTTAG GTCTTCAAGC AATGCGTGGA CTTTAAAGCA TGATTTAAAG 
TCGGGCCTCA TCACTTCCTT TGCTGTGGAC ATCCACCAAT GCTGGCTCTG CATTGGTACA 
AGCAGTGGTA CCATGGCTTG TTGGGACATG AGGTTCCAGT TGCCAATTTC AAGTCACTGT 
CATCCTTCCA GGGCTCGAAT CAGACGCCTC TCAATGCACC CTCTGTATCA GTCCTGGGTG 
ATTGCAGCTG TTCAGGGCAA CAACGAAGTG TCCATGTGGG ACATGGAGAC TGGTGACAGA 
AGATTTACTC TCTGGGCCAG CAGTGCACCA CCACTTTCTG AATTACAGCC TTCTCCTCAT 
AGCGTCCATG GTATCTACTG TAGTCCTGCA GATGGAAATC CTATCCTACT AACAGCTGGC 
TCAGATATGA AAATAAGGTT TTGGGACTTG GCTTACCCAG AAAGGTCCTA TGTTGTTGCA 
GGAAGTACTA GTTCCCCATC TGTGTCCTAC TACAGGAAAA TAATTGAAGG CACTGAAGTT 
GTCCAGGAAA TTCAGAATAA GCAGAAAGTA GGACCAAGTG ATGACACCCC TCGAAGGGGC 
CCAGAGTCCC TGCCCGTGGG ACATCATGAC ATCATCACTG ATGTCGCCAC ATTCCAGACC 
ACACAGGGCT TCATCGTAAC TGCTTCTAGA GATGGGATTG TGAAGGTGTG GAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055417.1
CDS	559..4635
Translation	MGNQLAGIAPSQILSVESYFSDIHDFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLNSAQNCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFFPEQVLNKIEDHSIRELVTQMIHREPDKRLEAEDYLKQQRGNAFPEIFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLCGHDLPEKAEGEPKENGLVILVSVITSCLQTLKYCDSKLAALELILHLAPRLSVEILLDRITPYLLHFSNDSVPRVRAEALRTLTKVLALVKEVPRNDINIYPEYILPGIAHLAQDDATIVRLAYAENIALLAETALRFLELVQLKNLNMENDPNNEEIDEVTHPNGNYDTELQALHEMVQQKVVTLLSDPENIVKQTLMENGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGVAAYVGWQSSSILKPLLQQGLSDAEEFVIVKALYALTCMCQLGLLQKPHVYEFASDIAPFLCHPNLWIRYGAVGFITVVARQISTADVYCKLMPYLDPYITQPIIQIERKLVLLSVLKEPVSRSIFDYALRSKDITSLFRHLHMRQKKRNGSLPDCPPPEDPAIAQLLKKLLSQGMTEEEEDKLLALKDFMMKSNKAKANIVDQSHLHDSSQKGVIDLAALGITGRQVDLVKTKQEPDDKRARKHVKQDSNVNEEWKSMFGSLDPPNMPQALPKGSDQEVIQTGKPPRSESSAGICVPLSTSSQVPEVTTVQNKKPVIPVLSSTILPSTYQIRITTCKTELQQLIQQKREQCNAERIAKQMMENAEWESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHSLFATCSNDGTVKIWNSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASKLPKSPKIHPLQSRILDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLKSGLITSFAVDIHQCWLCIGTSSGTMACWDMRFQLPISSHCHPSRARIRRLSMHPLYQSWVIAAVQGNNEVSMWDMETGDRRFTLWASSAPPLSELQPSPHSVHGIYCSPADGNPILLTAGSDMKIRFWDLAYPERSYVVAGSTSSPSVSYYRKIIEGTEVVQEIQNKQKVGPSDDTPRRGPESLPVGHHDIITDVATFQTTQGFIVTASRDGIVKVWK

Target ORF information:

RefSeq Version	NM_014602.3
Organism	Homo sapiens(human)
Definition	Homo sapiens phosphoinositide-3-kinase regulatory subunit 4 (PIK3R4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014602.3

ORF Insert Sequence:

ATGGGAAATC AGCTTGCTGG CATTGCTCCC TCCCAGATCC TTTCTGTAGA GAGTTATTTT 
TCAGATATTC ATGACTTTGA ATATGATAAA AGCCTGGGGA GTACTCGGTT TTTTAAAGTT 
GCTCGAGCCA AGCACCGAGA AGGCCTGGTC GTTGTGAAGG TTTTTGCAAT TCAGGATCCC 
ACATTGCCTT TAACCAGCTA TAAACAAGAG CTGGAGGAAC TGAAAATCAG GCTTAATTCT 
GCACAGAATT GTCTACCTTT CCAGAAAGCA TCAGAAAAAG CATCTGAGAA AGCAGCTATG 
CTCTTTAGGC AGTATGTGCG AGACAATCTC TATGATCGCA TCAGTACCCG TCCATTCTTG 
AATAACATTG AGAAGCGCTG GATTGCTTTC CAGATCCTGA CAGCTGTGGA CCAAGCACAC 
AAATCTGGAG TTCGTCATGG GGACATCAAG ACTGAGAATG TGATGGTCAC CAGTTGGAAT 
TGGGTTCTTC TAACTGATTT TGCCAGTTTT AAGCCCACTT ATCTTCCAGA AGACAACCCG 
GCAGATTTCA ATTATTTCTT TGACACATCA CGGAGGAGAA CTTGCTATAT TGCTCCTGAA 
CGTTTTGTTG ATGGTGGGAT GTTTGCCACT GAGTTAGAAT ATATGAGAGA TCCTTCAACT 
CCGCTTGTAG ACTTAAATAG CAATCAGAGA ACAAGAGGAG AGTTGAAGAG AGCAATGGAC 
ATCTTTTCAG CAGGTTGTGT GATAGCTGAG CTTTTTACAG AAGGTGTACC ATTATTTGAT 
CTCTCTCAAC TTTTGGCTTA TAGAAATGGA CATTTTTTCC CTGAACAAGT GCTAAATAAA 
ATTGAAGATC ACAGTATCAG AGAATTGGTA ACTCAGATGA TTCACCGTGA GCCAGATAAA 
CGTTTAGAGG CAGAAGATTA CTTAAAACAG CAGCGTGGCA ATGCCTTTCC TGAAATATTT 
TACACTTTTC TTCAGCCCTA CATGGCCCAG TTTGCCAAGG AAACGTTTCT TTCTGCAGAT 
GAGCGTATTC TGGTTATACG GAAGGATTTG GGCAACATTA TTCACAATCT CTGTGGACAT 
GATCTGCCAG AAAAAGCCGA AGGAGAGCCT AAGGAAAATG GGCTGGTTAT CTTGGTATCT 
GTTATAACAT CCTGCCTACA GACCCTTAAA TACTGTGATT CCAAACTAGC TGCTTTGGAA 
CTGATTCTTC ATTTGGCTCC AAGATTAAGT GTTGAAATCC TTTTGGATCG TATTACTCCA 
TATCTTTTGC ATTTCAGCAA TGACTCTGTT CCTAGGGTGA GGGCTGAAGC CTTGAGGACG 
TTGACCAAAG TTCTTGCTCT CGTCAAAGAG GTTCCTCGTA ATGATATCAA TATTTATCCG 
GAATACATTC TGCCAGGCAT AGCCCACTTA GCCCAAGATG ATGCTACTAT CGTTAGACTA 
GCCTATGCTG AAAACATAGC TCTGCTGGCA GAAACAGCTC TGAGATTCCT GGAATTAGTA 
CAGTTAAAAA ATCTTAATAT GGAAAATGAC CCCAATAATG AAGAAATAGA TGAGGTTACA 
CATCCAAATG GAAATTATGA CACAGAGCTC CAAGCCTTAC ATGAAATGGT CCAGCAGAAA 
GTTGTTACTT TGCTAAGTGA CCCTGAAAAT ATTGTAAAAC AAACCTTGAT GGAAAATGGA 
ATAACACGGC TGTGTGTATT CTTTGGACGT CAGAAAGCCA ACGATGTTTT GTTGTCCCAC 
ATGATTACTT TCCTAAATGA TAAGAATGAT TGGCATCTAC GTGGAGCATT TTTTGATAGT 
ATAGTTGGTG TTGCTGCCTA TGTTGGCTGG CAAAGCTCCT CAATTCTCAA GCCTCTGCTG 
CAACAAGGTC TTAGTGATGC TGAGGAATTT GTCATTGTGA AAGCTCTTTA TGCCCTTACT 
TGTATGTGCC AGTTAGGACT GCTACAAAAA CCCCATGTTT ACGAATTTGC CAGTGATATT 
GCCCCCTTCC TGTGTCATCC CAATTTATGG ATACGTTATG GTGCCGTGGG ATTTATCACA 
GTGGTAGCTC GTCAAATAAG TACAGCTGAT GTCTACTGTA AACTGATGCC TTATCTTGAC 
CCATATATTA CCCAACCAAT AATACAGATT GAAAGAAAAC TTGTTCTGCT CAGTGTTTTA 
AAGGAACCAG TAAGTCGTTC TATATTTGAT TATGCTTTGA GGTCTAAAGA TATTACTAGC 
TTGTTCAGAC ATCTTCACAT GCGTCAGAAG AAACGAAATG GTTCTCTTCC CGACTGCCCT 
CCGCCAGAGG ATCCTGCCAT AGCACAGCTT CTGAAGAAGT TGCTCTCACA GGGAATGACA 
GAGGAAGAGG AAGACAAACT TCTGGCACTG AAAGACTTCA TGATGAAATC TAATAAAGCA 
AAGGCCAATA TAGTGGACCA GAGCCATCTT CATGATAGTA GTCAGAAAGG TGTAATTGAC 
TTGGCAGCTT TAGGCATAAC TGGGAGACAA GTTGATCTTG TTAAAACCAA ACAAGAACCA 
GATGACAAAC GGGCCAGAAA ACATGTAAAA CAAGACTCAA ATGTAAATGA AGAATGGAAA 
AGCATGTTTG GGTCACTGGA CCCACCAAAC ATGCCACAGG CCCTACCTAA AGGGAGTGAT 
CAGGAGGTGA TTCAGACTGG GAAACCTCCT CGTTCCGAGT CCTCTGCTGG CATTTGTGTC 
CCTTTGTCAA CTTCTTCACA GGTTCCAGAA GTGACAACTG TCCAAAATAA AAAACCAGTA 
ATACCGGTTT TAAGTAGTAC AATCTTACCA TCCACCTATC AGATTCGAAT TACAACTTGT 
AAAACTGAAC TTCAGCAACT CATCCAGCAA AAGCGGGAGC AGTGCAATGC TGAGAGAATA 
GCTAAGCAGA TGATGGAAAA TGCTGAATGG GAGAGTAAAC CACCACCACC TGGATGGCGT 
CCTAAAGGGC TGTTAGTTGC CCATCTTCAT GAGCATAAAT CTGCTGTGAA TCGAATTAGA 
GTCTCTGATG AACACTCACT TTTTGCAACA TGTTCAAATG ATGGCACAGT GAAAATCTGG 
AACAGTCAAA AGATGGAGGG GAAGACCACC ACTACCAGAT CTATTCTTAC ATACAGCCGA 
ATTGGAGGAC GAGTCAAGAC GCTCACATTC TGCCAAGGCT CCCACTATTT AGCCATAGCA 
TCTGATAATG GTGCTGTCCA GCTTCTTGGA ATTGAGGCTT CTAAGCTGCC CAAGTCTCCT 
AAAATCCATC CTCTACAAAG CAGAATTCTA GATCAGAAGG AGGACGGTTG TGTTGTGGAT 
ATGCATCACT TCAACTCTGG AGCACAGTCT GTTCTTGCCT ATGCCACTGT GAATGGCTCT 
CTGGTTGGCT GGGACCTTAG GTCTTCAAGC AATGCGTGGA CTTTAAAGCA TGATTTAAAG 
TCGGGCCTCA TCACTTCCTT TGCTGTGGAC ATCCACCAAT GCTGGCTCTG CATTGGTACA 
AGCAGTGGTA CCATGGCTTG TTGGGACATG AGGTTCCAGT TGCCAATTTC AAGTCACTGT 
CATCCTTCCA GGGCTCGAAT CAGACGCCTC TCAATGCACC CTCTGTATCA GTCCTGGGTG 
ATTGCAGCTG TTCAGGGCAA CAACGAAGTG TCCATGTGGG ACATGGAGAC TGGTGACAGA 
AGATTTACTC TCTGGGCCAG CAGTGCACCA CCACTTTCTG AATTACAGCC TTCTCCTCAT 
AGCGTCCATG GTATCTACTG TAGTCCTGCA GATGGAAATC CTATCCTACT AACAGCTGGC 
TCAGATATGA AAATAAGGTT TTGGGACTTG GCTTACCCAG AAAGGTCCTA TGTTGTTGCA 
GGAAGTACTA GTTCCCCATC TGTGTCCTAC TACAGGAAAA TAATTGAAGG CACTGAAGTT 
GTCCAGGAAA TTCAGAATAA GCAGAAAGTA GGACCAAGTG ATGACACCCC TCGAAGGGGC 
CCAGAGTCCC TGCCCGTGGG ACATCATGAC ATCATCACTG ATGTCGCCAC ATTCCAGACC 
ACACAGGGCT TCATCGTAAC TGCTTCTAGA GATGGGATTG TGAAGGTGTG GAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.
Nature neuroscience21(2)207-217(2018 02)
Gstrein T,Edwards A,Přistoupilová A,Leca I,Breuss M,Pilat-Carotta S,Hansen AH,Tripathy R,Traunbauer AK,Hochstoeger T,Rosoklija G,Repic M,Landler L,Stránecký V,Dürnberger G,Keane TM,Zuber J,Adams DJ,Flint J,Honzik T,Gut M,Beltran S,Mechtler K,Sherr E,Kmoch S,Gut I,Keays DA

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Autophagy dysregulation in Danon disease.
Cell death & disease8(1)e2565(2017 01)
Nascimbeni AC,Fanin M,Angelini C,Sandri M

A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi.
Nature communications713586(2016 11)
Stoetzel C,Bär S,De Craene JO,Scheidecker S,Etard C,Chicher J,Reck JR,Perrault I,Geoffroy V,Chennen K,Strähle U,Hammann P,Friant S,Dollfus H

High expression of PI3K core complex genes is associated with poor prognosis in chronic lymphocytic leukemia.
Leukemia research39(6)555-60(2015 Jun)
Kristensen L,Kristensen T,Abildgaard N,Thomassen M,Frederiksen M,Mourits-Andersen T,Møller MB

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PIK3R4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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