| Gene Symbol | HBD |
| Entrez Gene ID | 3045 |
| Full Name | hemoglobin subunit delta |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The delta (HBD) and beta (HBB) genes are normally expressed in the adult: two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin. Two alpha chains plus two delta chains constitute HbA-2, which with HbF comprises the remaining 3% of adult hemoglobin. Five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon--Ggamma--Agamma--delta--beta-3'. Mutations in the delta-globin gene are associated with beta-thalassemia. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: | |
| Disorder Html: | Thalassemia, delta- (3); Thalassemia due to Hb Lepore (3) |
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HBD cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following HBD gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HBD cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu17826 
Clone ID Related Accession (Same CDS sequence) NM_000519.3 , NM_000519.4 Accession Version NM_000519.3 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 444bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1506700800000 Organism Homo sapiens(human) Product hemoglobin subunit delta Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY034468.1, BC070282.1 and BU664913.1. This sequence is a reference standard in the RefSeqGene project. On Apr 22, 2005 this sequence version replaced NM_000519.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY034468.1, SRR1163658.247873.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149004, SAMEA2154529 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421ATGGTGCATC TGACTCCTGA GGAGAAGACT GCTGTCAATG CCCTGTGGGG CAAAGTGAAC
GTGGATGCAG TTGGTGGTGA GGCCCTGGGC AGATTACTGG TGGTCTACCC TTGGACCCAG
AGGTTCTTTG AGTCCTTTGG GGATCTGTCC TCTCCTGATG CTGTTATGGG CAACCCTAAG
GTGAAGGCTC ATGGCAAGAA GGTGCTAGGT GCCTTTAGTG ATGGCCTGGC TCACCTGGAC
AACCTCAAGG GCACTTTTTC TCAGCTGAGT GAGCTGCACT GTGACAAGCT GCACGTGGAT
CCTGAGAACT TCAGGCTCTT GGGCAATGTG CTGGTGTGTG TGCTGGCCCG CAACTTTGGC
AAGGAATTCA CCCCACAAAT GCAGGCTGCC TATCAGAAGG TGGTGGCTGG TGTGGCTAAT
GCCCTGGCTC ACAAGTACCA TTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_000510.1 CDS 196..639 Translation 
Target ORF information:
RefSeq Version NM_000519.3 Organism Homo sapiens(human) Definition Homo sapiens hemoglobin subunit delta (HBD), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_000519.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421ATGGTGCATC TGACTCCTGA GGAGAAGACT GCTGTCAATG CCCTGTGGGG CAAAGTGAAC
GTGGATGCAG TTGGTGGTGA GGCCCTGGGC AGATTACTGG TGGTCTACCC TTGGACCCAG
AGGTTCTTTG AGTCCTTTGG GGATCTGTCC TCTCCTGATG CTGTTATGGG CAACCCTAAG
GTGAAGGCTC ATGGCAAGAA GGTGCTAGGT GCCTTTAGTG ATGGCCTGGC TCACCTGGAC
AACCTCAAGG GCACTTTTTC TCAGCTGAGT GAGCTGCACT GTGACAAGCT GCACGTGGAT
CCTGAGAACT TCAGGCTCTT GGGCAATGTG CTGGTGTGTG TGCTGGCCCG CAACTTTGGC
AAGGAATTCA CCCCACAAAT GCAGGCTGCC TATCAGAAGG TGGTGGCTGG TGTGGCTAAT
GCCCTGGCTC ACAAGTACCA TTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu17826 Clone ID Related Accession (Same CDS sequence) NM_000519.3 , NM_000519.4 Accession Version NM_000519.4 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 444bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1569427200000 Organism Homo sapiens(human) Product hemoglobin subunit delta Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY034468.1, BC070282.1 and BU664913.1. This sequence is a reference standard in the RefSeqGene project. On Dec 7, 2018 this sequence version replaced NM_000519.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.29352.1, BU663989.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149004, SAMEA2154529 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000650601.1/ ENSP00000497529.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421ATGGTGCATC TGACTCCTGA GGAGAAGACT GCTGTCAATG CCCTGTGGGG CAAAGTGAAC
GTGGATGCAG TTGGTGGTGA GGCCCTGGGC AGATTACTGG TGGTCTACCC TTGGACCCAG
AGGTTCTTTG AGTCCTTTGG GGATCTGTCC TCTCCTGATG CTGTTATGGG CAACCCTAAG
GTGAAGGCTC ATGGCAAGAA GGTGCTAGGT GCCTTTAGTG ATGGCCTGGC TCACCTGGAC
AACCTCAAGG GCACTTTTTC TCAGCTGAGT GAGCTGCACT GTGACAAGCT GCACGTGGAT
CCTGAGAACT TCAGGCTCTT GGGCAATGTG CTGGTGTGTG TGCTGGCCCG CAACTTTGGC
AAGGAATTCA CCCCACAAAT GCAGGCTGCC TATCAGAAGG TGGTGGCTGG TGTGGCTAAT
GCCCTGGCTC ACAAGTACCA TTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_000510.1 CDS 51..494 Translation
Target ORF information:
RefSeq Version NM_000519.4 Organism Homo sapiens(human) Definition Homo sapiens hemoglobin subunit delta (HBD), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_000519.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421ATGGTGCATC TGACTCCTGA GGAGAAGACT GCTGTCAATG CCCTGTGGGG CAAAGTGAAC
GTGGATGCAG TTGGTGGTGA GGCCCTGGGC AGATTACTGG TGGTCTACCC TTGGACCCAG
AGGTTCTTTG AGTCCTTTGG GGATCTGTCC TCTCCTGATG CTGTTATGGG CAACCCTAAG
GTGAAGGCTC ATGGCAAGAA GGTGCTAGGT GCCTTTAGTG ATGGCCTGGC TCACCTGGAC
AACCTCAAGG GCACTTTTTC TCAGCTGAGT GAGCTGCACT GTGACAAGCT GCACGTGGAT
CCTGAGAACT TCAGGCTCTT GGGCAATGTG CTGGTGTGTG TGCTGGCCCG CAACTTTGGC
AAGGAATTCA CCCCACAAAT GCAGGCTGCC TATCAGAAGG TGGTGGCTGG TGTGGCTAAT
GCCCTGGCTC ACAAGTACCA TTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Blood donor homozygous for Hb D Los Angeles.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis51(2)219-20(2014 Oct)
Silva-Pinto AC,Silva TJ,Moretto EL,Ottoboni MÂ,Rodrigues ES,Covas DT
In vivo activation of the human δ-globin gene: the therapeutic potential in β-thalassemic mice.
Haematologica99(1)76-84(2014 Jan)
Manchinu MF,Marongiu MF,Poddie D,Casu C,Latini V,Simbula M,Galanello R,Moi P,Cao A,Porcu S,Ristaldi MS
GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.
Human molecular genetics22(7)1457-64(2013 Apr)
Li J,Glessner JT,Zhang H,Hou C,Wei Z,Bradfield JP,Mentch FD,Guo Y,Kim C,Xia Q,Chiavacci RM,Thomas KA,Qiu H,Grant SF,Furth SL,Hakonarson H,Sleiman PM
Analysis of δ-globin gene mutations in the Chinese population.
Hemoglobin37(1)85-93(2013)
Liu N,Xie XM,Zhou JY,Li R,Liao C,Li DZ
Two complex associations of an HBD mutation and a rare α hemoglobinopathy.
Hemoglobin37(5)486-91(2013)
Joly P,Lacan P,Garcia C,Francina A
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