GPR3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GPR3
Entrez Gene ID	2827
Full Name	G protein-coupled receptor 3
Synonyms	ACCA
General protein information	Preferred Names G protein-coupled receptor 3 Names G-protein coupled receptor 3 ACCA orphan receptor adenylate cyclase constitutive activator
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.11
Summary	This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012].
Disorder MIM:	600241

mRNA and Protein(s)

mRNA	Protein	Name
NM_005281.4	NP_005272.1	G-protein coupled receptor 3
NM_005281.3	NP_005272.1	G-protein coupled receptor 3

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	GPR3	XP_001111240.1
Canis lupus familiaris (dog)	GPR3	XP_544470.1
Rattus norvegicus (Norway rat)	Gpr3	NP_714949.1
Homo sapiens (human)	GPR3	NP_005272.1
Mus musculus (house mouse)	Gpr3	NP_032180.1
Pan troglodytes (chimpanzee)	GPR3	XP_001148989.1
Bos taurus (cattle)	GPR3	XP_005203355.1

Gene Ontology
Bibliography

Related articles in PubMed

Allosteric sodium binding cavity in GPR3: a novel player in modulation of Aβ production.
Capaldi S, Suku E, Antolini M, Di Giacobbe M, Giorgetti A, Buffelli M
Scientific reports8(1)11102(2018 07)

Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue.
Godlewski G, Jourdan T, Szanda G, Tam J, Cinar R, Harvey-White J, Liu J, Mukhopadhyay B, Pacher P, Ming Mo F, Osei-Hyiaman D, Kunos G
Scientific reports514953(2015 Oct)

[G protein-coupled receptor 3: a key factor in the regulation of the nervous system and follicle development].
Zhang BL, Gao DS, Xu YX
Yi chuan = Hereditas35(5)578-86(2013 May)

Gpr3 stimulates Aβ production via interactions with APP and β-arrestin2.
Nelson CD, Sheng M
PloS one8(9)e74680(2013)

Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells.
Lowther KM, Uliasz TF, Götz KR, Nikolaev VO, Mehlmann LM
PloS one8(6)e65365(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GPR3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPR3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23460	NM_005281.4 Latest version!	Homo sapiens G protein-coupled receptor 3 (GPR3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$216.30 $309.00
View Old Accession Versions >>
OHu23460	NM_005281.3	Homo sapiens G protein-coupled receptor 3 (GPR3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GPR3 ( NM_005281.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005272.1 Homo sapiens G protein-coupled receptor 3 (GPR3), mRNA.

Price & Availability↑

CloneID	OHu23460
Clone ID Related Accession (Same CDS sequence)	NM_005281.4 , NM_005281.3
Accession Version	NM_005281.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571932800000
Organism	Homo sapiens(human)
Product	G-protein coupled receptor 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from FO393419.1. On Nov 23, 2018 this sequence version replaced NM_005281.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.284479.1, SRR3476690.1119222.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000374024.4/ ENSP00000363136.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATGTGGG GTGCAGGCAG CCCTCTGGCC TGGCTCTCAG CTGGCTCAGG CAACGTGAAT 
GTAAGCAGCG TGGGCCCAGC AGAGGGGCCC ACAGGTCCAG CCGCACCACT GCCCTCGCCT 
AAGGCCTGGG ATGTGGTGCT CTGCATCTCA GGCACCCTGG TGTCCTGCGA GAATGCGCTA 
GTGGTGGCCA TCATCGTGGG CACTCCTGCC TTCCGTGCCC CCATGTTCCT GCTGGTGGGC 
AGCCTGGCCG TGGCAGACCT GCTGGCAGGC CTGGGCCTGG TCCTGCACTT TGCTGCTGTC 
TTCTGCATCG GCTCAGCGGA GATGAGCCTG GTGCTGGTTG GCGTGCTGGC AATGGCCTTT 
ACCGCCAGCA TCGGCAGTCT ACTGGCCATC ACTGTCGACC GCTACCTTTC TCTGTACAAT 
GCCCTCACCT ACTATTCAGA GACAACAGTG ACACGGACCT ATGTGATGCT GGCCTTAGTG 
TGGGGAGGTG CCCTGGGCCT GGGGCTGCTG CCTGTGCTGG CCTGGAACTG CCTGGATGGC 
CTGACCACAT GTGGCGTGGT TTATCCACTC TCCAAGAACC ATCTGGTAGT TCTGGCCATT 
GCCTTCTTCA TGGTGTTTGG CATCATGCTG CAGCTCTACG CCCAAATCTG CCGCATCGTC 
TGCCGCCATG CCCAGCAGAT TGCCCTTCAG CGGCACCTGC TGCCTGCCTC CCACTATGTG 
GCCACCCGCA AGGGCATTGC CACACTGGCC GTGGTGCTTG GAGCCTTTGC CGCCTGCTGG 
TTGCCCTTCA CTGTCTACTG CCTGCTGGGT GATGCCCACT CTCCACCTCT CTACACCTAT 
CTTACCTTGC TCCCTGCCAC CTACAACTCC ATGATCAACC CTATCATCTA CGCCTTCCGC 
AACCAGGATG TGCAGAAAGT GCTGTGGGCT GTCTGCTGCT GCTGTTCCTC TTCCAAGATC 
CCCTTCCGAT CCCGCTCCCC CAGTGATGTC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005272.1
CDS	122..1114
Translation	MMWGAGSPLAWLSAGSGNVNVSSVGPAEGPTGPAAPLPSPKAWDVVLCISGTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAAVFCIGSAEMSLVLVGVLAMAFTASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWGGALGLGLLPVLAWNCLDGLTTCGVVYPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPASHYVATRKGIATLAVVLGAFAACWLPFTVYCLLGDAHSPPLYTYLTLLPATYNSMINPIIYAFRNQDVQKVLWAVCCCCSSSKIPFRSRSPSDV

Target ORF information:

RefSeq Version	NM_005281.4
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein-coupled receptor 3 (GPR3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005281.4

ORF Insert Sequence:

ATGATGTGGG GTGCAGGCAG CCCTCTGGCC TGGCTCTCAG CTGGCTCAGG CAACGTGAAT 
GTAAGCAGCG TGGGCCCAGC AGAGGGGCCC ACAGGTCCAG CCGCACCACT GCCCTCGCCT 
AAGGCCTGGG ATGTGGTGCT CTGCATCTCA GGCACCCTGG TGTCCTGCGA GAATGCGCTA 
GTGGTGGCCA TCATCGTGGG CACTCCTGCC TTCCGTGCCC CCATGTTCCT GCTGGTGGGC 
AGCCTGGCCG TGGCAGACCT GCTGGCAGGC CTGGGCCTGG TCCTGCACTT TGCTGCTGTC 
TTCTGCATCG GCTCAGCGGA GATGAGCCTG GTGCTGGTTG GCGTGCTGGC AATGGCCTTT 
ACCGCCAGCA TCGGCAGTCT ACTGGCCATC ACTGTCGACC GCTACCTTTC TCTGTACAAT 
GCCCTCACCT ACTATTCAGA GACAACAGTG ACACGGACCT ATGTGATGCT GGCCTTAGTG 
TGGGGAGGTG CCCTGGGCCT GGGGCTGCTG CCTGTGCTGG CCTGGAACTG CCTGGATGGC 
CTGACCACAT GTGGCGTGGT TTATCCACTC TCCAAGAACC ATCTGGTAGT TCTGGCCATT 
GCCTTCTTCA TGGTGTTTGG CATCATGCTG CAGCTCTACG CCCAAATCTG CCGCATCGTC 
TGCCGCCATG CCCAGCAGAT TGCCCTTCAG CGGCACCTGC TGCCTGCCTC CCACTATGTG 
GCCACCCGCA AGGGCATTGC CACACTGGCC GTGGTGCTTG GAGCCTTTGC CGCCTGCTGG 
TTGCCCTTCA CTGTCTACTG CCTGCTGGGT GATGCCCACT CTCCACCTCT CTACACCTAT 
CTTACCTTGC TCCCTGCCAC CTACAACTCC ATGATCAACC CTATCATCTA CGCCTTCCGC 
AACCAGGATG TGCAGAAAGT GCTGTGGGCT GTCTGCTGCT GCTGTTCCTC TTCCAAGATC 
CCCTTCCGAT CCCGCTCCCC CAGTGATGTC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GPR3 ( NM_005281.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005272.1 Homo sapiens G protein-coupled receptor 3 (GPR3), mRNA.

Price & Availability↑

CloneID	OHu23460
Clone ID Related Accession (Same CDS sequence)	NM_005281.4 , NM_005281.3
Accession Version	NM_005281.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1507996800000
Organism	Homo sapiens(human)
Product	G-protein coupled receptor 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ882813.1 and BC032702.1. On Oct 18, 2012 this sequence version replaced NM_005281.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC032702.1, SRR1803613.280390.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGTGGG GTGCAGGCAG CCCTCTGGCC TGGCTCTCAG CTGGCTCAGG CAACGTGAAT 
GTAAGCAGCG TGGGCCCAGC AGAGGGGCCC ACAGGTCCAG CCGCACCACT GCCCTCGCCT 
AAGGCCTGGG ATGTGGTGCT CTGCATCTCA GGCACCCTGG TGTCCTGCGA GAATGCGCTA 
GTGGTGGCCA TCATCGTGGG CACTCCTGCC TTCCGTGCCC CCATGTTCCT GCTGGTGGGC 
AGCCTGGCCG TGGCAGACCT GCTGGCAGGC CTGGGCCTGG TCCTGCACTT TGCTGCTGTC 
TTCTGCATCG GCTCAGCGGA GATGAGCCTG GTGCTGGTTG GCGTGCTGGC AATGGCCTTT 
ACCGCCAGCA TCGGCAGTCT ACTGGCCATC ACTGTCGACC GCTACCTTTC TCTGTACAAT 
GCCCTCACCT ACTATTCAGA GACAACAGTG ACACGGACCT ATGTGATGCT GGCCTTAGTG 
TGGGGAGGTG CCCTGGGCCT GGGGCTGCTG CCTGTGCTGG CCTGGAACTG CCTGGATGGC 
CTGACCACAT GTGGCGTGGT TTATCCACTC TCCAAGAACC ATCTGGTAGT TCTGGCCATT 
GCCTTCTTCA TGGTGTTTGG CATCATGCTG CAGCTCTACG CCCAAATCTG CCGCATCGTC 
TGCCGCCATG CCCAGCAGAT TGCCCTTCAG CGGCACCTGC TGCCTGCCTC CCACTATGTG 
GCCACCCGCA AGGGCATTGC CACACTGGCC GTGGTGCTTG GAGCCTTTGC CGCCTGCTGG 
TTGCCCTTCA CTGTCTACTG CCTGCTGGGT GATGCCCACT CTCCACCTCT CTACACCTAT 
CTTACCTTGC TCCCTGCCAC CTACAACTCC ATGATCAACC CTATCATCTA CGCCTTCCGC 
AACCAGGATG TGCAGAAAGT GCTGTGGGCT GTCTGCTGCT GCTGTTCCTC TTCCAAGATC 
CCCTTCCGAT CCCGCTCCCC CAGTGATGTC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005272.1
CDS	100..1092
Translation	MMWGAGSPLAWLSAGSGNVNVSSVGPAEGPTGPAAPLPSPKAWDVVLCISGTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAAVFCIGSAEMSLVLVGVLAMAFTASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWGGALGLGLLPVLAWNCLDGLTTCGVVYPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPASHYVATRKGIATLAVVLGAFAACWLPFTVYCLLGDAHSPPLYTYLTLLPATYNSMINPIIYAFRNQDVQKVLWAVCCCCSSSKIPFRSRSPSDV

Target ORF information:

RefSeq Version	NM_005281.3
Organism	Homo sapiens(human)
Definition	Homo sapiens G protein-coupled receptor 3 (GPR3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005281.3

ORF Insert Sequence:

ATGATGTGGG GTGCAGGCAG CCCTCTGGCC TGGCTCTCAG CTGGCTCAGG CAACGTGAAT 
GTAAGCAGCG TGGGCCCAGC AGAGGGGCCC ACAGGTCCAG CCGCACCACT GCCCTCGCCT 
AAGGCCTGGG ATGTGGTGCT CTGCATCTCA GGCACCCTGG TGTCCTGCGA GAATGCGCTA 
GTGGTGGCCA TCATCGTGGG CACTCCTGCC TTCCGTGCCC CCATGTTCCT GCTGGTGGGC 
AGCCTGGCCG TGGCAGACCT GCTGGCAGGC CTGGGCCTGG TCCTGCACTT TGCTGCTGTC 
TTCTGCATCG GCTCAGCGGA GATGAGCCTG GTGCTGGTTG GCGTGCTGGC AATGGCCTTT 
ACCGCCAGCA TCGGCAGTCT ACTGGCCATC ACTGTCGACC GCTACCTTTC TCTGTACAAT 
GCCCTCACCT ACTATTCAGA GACAACAGTG ACACGGACCT ATGTGATGCT GGCCTTAGTG 
TGGGGAGGTG CCCTGGGCCT GGGGCTGCTG CCTGTGCTGG CCTGGAACTG CCTGGATGGC 
CTGACCACAT GTGGCGTGGT TTATCCACTC TCCAAGAACC ATCTGGTAGT TCTGGCCATT 
GCCTTCTTCA TGGTGTTTGG CATCATGCTG CAGCTCTACG CCCAAATCTG CCGCATCGTC 
TGCCGCCATG CCCAGCAGAT TGCCCTTCAG CGGCACCTGC TGCCTGCCTC CCACTATGTG 
GCCACCCGCA AGGGCATTGC CACACTGGCC GTGGTGCTTG GAGCCTTTGC CGCCTGCTGG 
TTGCCCTTCA CTGTCTACTG CCTGCTGGGT GATGCCCACT CTCCACCTCT CTACACCTAT 
CTTACCTTGC TCCCTGCCAC CTACAACTCC ATGATCAACC CTATCATCTA CGCCTTCCGC 
AACCAGGATG TGCAGAAAGT GCTGTGGGCT GTCTGCTGCT GCTGTTCCTC TTCCAAGATC 
CCCTTCCGAT CCCGCTCCCC CAGTGATGTC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Allosteric sodium binding cavity in GPR3: a novel player in modulation of Aβ production.
Scientific reports8(1)11102(2018 07)
Capaldi S,Suku E,Antolini M,Di Giacobbe M,Giorgetti A,Buffelli M

Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue.
Scientific reports514953(2015 Oct)
Godlewski G,Jourdan T,Szanda G,Tam J,Cinar R,Harvey-White J,Liu J,Mukhopadhyay B,Pacher P,Ming Mo F,Osei-Hyiaman D,Kunos G

[G protein-coupled receptor 3: a key factor in the regulation of the nervous system and follicle development].
Yi chuan = Hereditas35(5)578-86(2013 May)
Zhang BL,Gao DS,Xu YX

Gpr3 stimulates Aβ production via interactions with APP and β-arrestin2.
PloS one8(9)e74680(2013)
Nelson CD,Sheng M

Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells.
PloS one8(6)e65365(2013)
Lowther KM,Uliasz TF,Götz KR,Nikolaev VO,Mehlmann LM

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GPR3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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