GJB5 cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GJB5
Entrez Gene ID	2709
Full Name	gap junction protein beta 5
Synonyms	CX31.1
General protein information	Preferred Names gap junction protein beta 5 Names gap junction beta-5 protein gap junction protein, beta 5 (connexin 31.1) gap junction protein, beta 5, 31.1kDa gap junctional protein cx31.1
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 1 Map Location: 1p34.3
Summary	This gene encodes a member of the beta-type (group I) connexin family. The encoded protein is a gap junction protein involved in intercellular communication related to epidermal differentiation and environmental sensing. This gene has been linked to non-small cell lung cancer. [provided by RefSeq, Nov 2012].
Disorder MIM:	604493

mRNA and Protein(s)

mRNA	Protein	Name
XM_005270751.3	XP_005270808.1	gap junction beta-5 protein isoform X1
NM_005268.3	NP_005259.1	gap junction beta-5 protein
NM_005268.4	NP_005259.1	gap junction beta-5 protein
XM_005270751.2	XP_005270808.1	gap junction beta-5 protein isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	GJB5	XP_005629034.1
Bos taurus (cattle)	GJB5	NP_001192836.1
Homo sapiens (human)	GJB5	NP_005259.1
Xenopus tropicalis (tropical clawed frog)	LOC101734565	XP_004911667.1
Mus musculus (house mouse)	Gjb5	NP_034421.1
Gallus gallus (chicken)	GJB5	XP_004947839.1
Macaca mulatta (Rhesus monkey)	GJB5	XP_001108635.1
Rattus norvegicus (Norway rat)	Gjb5	NP_062114.1
Pan troglodytes (chimpanzee)	GJB5	XP_003308015.1

Gene Ontology
Bibliography

Related articles in PubMed

Connexin 31.1 degradation requires the Clathrin-mediated autophagy in NSCLC cell H1299.
Zhu X, Ruan Z, Yang X, Chu K, Wu H, Li Y, Huang Y
Journal of cellular and molecular medicine19(1)257-64(2015 Jan)

Cx31.1 acts as a tumour suppressor in non-small cell lung cancer (NSCLC) cell lines through inhibition of cell proliferation and metastasis.
Zhang D, Chen C, Li Y, Fu X, Xie Y, Li Y, Huang Y
Journal of cellular and molecular medicine16(5)1047-59(2012 May)

Connexin mutations in Brazilian patients with skin disorders with or without hearing loss.
Alexandrino F, de Oliveira CA, Magalhães RF, Florence ME, de Souza EM, Sartorato EL
American journal of medical genetics. Part A149A(4)681-4(2009 Feb)

Reduced expression of connexin 31.1 in larynx cancer is not caused by GJB5 mutations.
Broghammer M, Leistenschneider P, Baus-Loncar M, Blin N, Sasiadek MM, Pusch CM
Cancer letters214(2)225-9(2004 Oct)

Cloning, mapping and mutation analysis of human geneGJB5 encoding gap junction protein beta-5.
Xia J, Zheng D, Tang D, Dai H, Pan Q, Long Z, Liao X
Science in China. Series C, Life sciences44(1)92-8(2001 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GJB5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GJB5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04849	NM_005268.4 Latest version!	Homo sapiens gap junction protein beta 5 (GJB5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$139.30 $199.00
OHu04849	XM_005270751.3 Latest version!	Homo sapiens gap junction protein beta 5 (GJB5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$139.30 $199.00
View Old Accession Versions >>
OHu04849	NM_005268.3	Homo sapiens gap junction protein beta 5 (GJB5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$139.30 $199.00
OHu04849	XM_005270751.2	Homo sapiens gap junction protein, beta 5, 31.1kDa (GJB5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GJB5 ( NM_005268.3 ) cDNA ORF clone, Homo sapiens(Human) -> NP_005259.1 Homo sapiens gap junction protein beta 5 (GJB5), mRNA.

Price & Availability↑

CloneID	OHu04849
Clone ID Related Accession (Same CDS sequence)	XM_005270751.3 , NM_005268.3 , NM_005268.4 , XM_005270751.2
Accession Version	NM_005268.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506873600000
Organism	Homo sapiens(human)
Product	gap junction beta-5 protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK129509.1, BC004379.1 and AA877961.1. On Nov 30, 2012 this sequence version replaced NM_005268.2. ##Evidence-Data-START## Transcript exon combination :: AK129509.1, BC004379.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144335, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAACTGGA GTATCTTTGA GGGACTCCTG AGTGGGGTCA ACAAGTACTC CACAGCCTTT 
GGGCGCATCT GGCTGTCTCT GGTCTTCATC TTCCGCGTGC TGGTGTACCT GGTGACGGCC 
GAGCGTGTGT GGAGTGATGA CCACAAGGAC TTCGACTGCA ATACTCGCCA GCCCGGCTGC 
TCCAACGTCT GCTTTGATGA GTTCTTCCCT GTGTCCCATG TGCGCCTCTG GGCCCTGCAG 
CTTATCCTGG TGACATGCCC CTCACTGCTC GTGGTCATGC ACGTGGCCTA CCGGGAGGTT 
CAGGAGAAGA GGCACCGAGA AGCCCATGGG GAGAACAGTG GGCGCCTCTA CCTGAACCCC 
GGCAAGAAGC GGGGTGGGCT CTGGTGGACA TATGTCTGCA GCCTAGTGTT CAAGGCGAGC 
GTGGACATCG CCTTTCTCTA TGTGTTCCAC TCATTCTACC CCAAATATAT CCTCCCTCCT 
GTGGTCAAGT GCCACGCAGA TCCATGTCCC AATATAGTGG ACTGCTTCAT CTCCAAGCCC 
TCAGAGAAGA ACATTTTCAC CCTCTTCATG GTGGCCACAG CTGCCATCTG CATCCTGCTC 
AACCTCGTGG AGCTCATCTA CCTGGTGAGC AAGAGATGCC ACGAGTGCCT GGCAGCAAGG 
AAAGCTCAAG CCATGTGCAC AGGTCATCAC CCCCACGGTA CCACCTCTTC CTGCAAACAA 
GACGACCTCC TTTCGGGTGA CCTCATCTTT CTGGGCTCAG ACAGTCATCC TCCTCTCTTA 
CCAGACCGCC CCCGAGACCA TGTGAAGAAA ACCATCTTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005259.1
CDS	174..995
Translation	MNWSIFEGLLSGVNKYSTAFGRIWLSLVFIFRVLVYLVTAERVWSDDHKDFDCNTRQPGCSNVCFDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREVQEKRHREAHGENSGRLYLNPGKKRGGLWWTYVCSLVFKASVDIAFLYVFHSFYPKYILPPVVKCHADPCPNIVDCFISKPSEKNIFTLFMVATAAICILLNLVELIYLVSKRCHECLAARKAQAMCTGHHPHGTTSSCKQDDLLSGDLIFLGSDSHPPLLPDRPRDHVKKTIL

Target ORF information:

RefSeq Version	NM_005268.3
Organism	Homo sapiens(human)
Definition	Homo sapiens gap junction protein beta 5 (GJB5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005268.3

ORF Insert Sequence:

ATGAACTGGA GTATCTTTGA GGGACTCCTG AGTGGGGTCA ACAAGTACTC CACAGCCTTT 
GGGCGCATCT GGCTGTCTCT GGTCTTCATC TTCCGCGTGC TGGTGTACCT GGTGACGGCC 
GAGCGTGTGT GGAGTGATGA CCACAAGGAC TTCGACTGCA ATACTCGCCA GCCCGGCTGC 
TCCAACGTCT GCTTTGATGA GTTCTTCCCT GTGTCCCATG TGCGCCTCTG GGCCCTGCAG 
CTTATCCTGG TGACATGCCC CTCACTGCTC GTGGTCATGC ACGTGGCCTA CCGGGAGGTT 
CAGGAGAAGA GGCACCGAGA AGCCCATGGG GAGAACAGTG GGCGCCTCTA CCTGAACCCC 
GGCAAGAAGC GGGGTGGGCT CTGGTGGACA TATGTCTGCA GCCTAGTGTT CAAGGCGAGC 
GTGGACATCG CCTTTCTCTA TGTGTTCCAC TCATTCTACC CCAAATATAT CCTCCCTCCT 
GTGGTCAAGT GCCACGCAGA TCCATGTCCC AATATAGTGG ACTGCTTCAT CTCCAAGCCC 
TCAGAGAAGA ACATTTTCAC CCTCTTCATG GTGGCCACAG CTGCCATCTG CATCCTGCTC 
AACCTCGTGG AGCTCATCTA CCTGGTGAGC AAGAGATGCC ACGAGTGCCT GGCAGCAAGG 
AAAGCTCAAG CCATGTGCAC AGGTCATCAC CCCCACGGTA CCACCTCTTC CTGCAAACAA 
GACGACCTCC TTTCGGGTGA CCTCATCTTT CTGGGCTCAG ACAGTCATCC TCCTCTCTTA 
CCAGACCGCC CCCGAGACCA TGTGAAGAAA ACCATCTTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GJB5 ( NM_005268.4 ) cDNA ORF clone, Homo sapiens(Human) -> NP_005259.1 Homo sapiens gap junction protein beta 5 (GJB5), mRNA.

Price & Availability↑

CloneID	OHu04849
Clone ID Related Accession (Same CDS sequence)	XM_005270751.3 , NM_005268.3 , NM_005268.4 , XM_005270751.2
Accession Version	NM_005268.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	gap junction beta-5 protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK129509.1, BC004379.1 and AA877961.1. On Nov 22, 2018 this sequence version replaced NM_005268.3. ##Evidence-Data-START## Transcript exon combination :: AK129509.1, SRR3476690.4307.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144335, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000338513.1/ ENSP00000340811.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAACTGGA GTATCTTTGA GGGACTCCTG AGTGGGGTCA ACAAGTACTC CACAGCCTTT 
GGGCGCATCT GGCTGTCTCT GGTCTTCATC TTCCGCGTGC TGGTGTACCT GGTGACGGCC 
GAGCGTGTGT GGAGTGATGA CCACAAGGAC TTCGACTGCA ATACTCGCCA GCCCGGCTGC 
TCCAACGTCT GCTTTGATGA GTTCTTCCCT GTGTCCCATG TGCGCCTCTG GGCCCTGCAG 
CTTATCCTGG TGACATGCCC CTCACTGCTC GTGGTCATGC ACGTGGCCTA CCGGGAGGTT 
CAGGAGAAGA GGCACCGAGA AGCCCATGGG GAGAACAGTG GGCGCCTCTA CCTGAACCCC 
GGCAAGAAGC GGGGTGGGCT CTGGTGGACA TATGTCTGCA GCCTAGTGTT CAAGGCGAGC 
GTGGACATCG CCTTTCTCTA TGTGTTCCAC TCATTCTACC CCAAATATAT CCTCCCTCCT 
GTGGTCAAGT GCCACGCAGA TCCATGTCCC AATATAGTGG ACTGCTTCAT CTCCAAGCCC 
TCAGAGAAGA ACATTTTCAC CCTCTTCATG GTGGCCACAG CTGCCATCTG CATCCTGCTC 
AACCTCGTGG AGCTCATCTA CCTGGTGAGC AAGAGATGCC ACGAGTGCCT GGCAGCAAGG 
AAAGCTCAAG CCATGTGCAC AGGTCATCAC CCCCACGGTA CCACCTCTTC CTGCAAACAA 
GACGACCTCC TTTCGGGTGA CCTCATCTTT CTGGGCTCAG ACAGTCATCC TCCTCTCTTA 
CCAGACCGCC CCCGAGACCA TGTGAAGAAA ACCATCTTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005259.1
CDS	174..995
Translation	MNWSIFEGLLSGVNKYSTAFGRIWLSLVFIFRVLVYLVTAERVWSDDHKDFDCNTRQPGCSNVCFDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREVQEKRHREAHGENSGRLYLNPGKKRGGLWWTYVCSLVFKASVDIAFLYVFHSFYPKYILPPVVKCHADPCPNIVDCFISKPSEKNIFTLFMVATAAICILLNLVELIYLVSKRCHECLAARKAQAMCTGHHPHGTTSSCKQDDLLSGDLIFLGSDSHPPLLPDRPRDHVKKTIL

Target ORF information:

RefSeq Version	NM_005268.4
Organism	Homo sapiens(human)
Definition	Homo sapiens gap junction protein beta 5 (GJB5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005268.4

ORF Insert Sequence:

ATGAACTGGA GTATCTTTGA GGGACTCCTG AGTGGGGTCA ACAAGTACTC CACAGCCTTT 
GGGCGCATCT GGCTGTCTCT GGTCTTCATC TTCCGCGTGC TGGTGTACCT GGTGACGGCC 
GAGCGTGTGT GGAGTGATGA CCACAAGGAC TTCGACTGCA ATACTCGCCA GCCCGGCTGC 
TCCAACGTCT GCTTTGATGA GTTCTTCCCT GTGTCCCATG TGCGCCTCTG GGCCCTGCAG 
CTTATCCTGG TGACATGCCC CTCACTGCTC GTGGTCATGC ACGTGGCCTA CCGGGAGGTT 
CAGGAGAAGA GGCACCGAGA AGCCCATGGG GAGAACAGTG GGCGCCTCTA CCTGAACCCC 
GGCAAGAAGC GGGGTGGGCT CTGGTGGACA TATGTCTGCA GCCTAGTGTT CAAGGCGAGC 
GTGGACATCG CCTTTCTCTA TGTGTTCCAC TCATTCTACC CCAAATATAT CCTCCCTCCT 
GTGGTCAAGT GCCACGCAGA TCCATGTCCC AATATAGTGG ACTGCTTCAT CTCCAAGCCC 
TCAGAGAAGA ACATTTTCAC CCTCTTCATG GTGGCCACAG CTGCCATCTG CATCCTGCTC 
AACCTCGTGG AGCTCATCTA CCTGGTGAGC AAGAGATGCC ACGAGTGCCT GGCAGCAAGG 
AAAGCTCAAG CCATGTGCAC AGGTCATCAC CCCCACGGTA CCACCTCTTC CTGCAAACAA 
GACGACCTCC TTTCGGGTGA CCTCATCTTT CTGGGCTCAG ACAGTCATCC TCCTCTCTTA 
CCAGACCGCC CCCGAGACCA TGTGAAGAAA ACCATCTTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GJB5 ( XM_005270751.3 ) cDNA ORF clone, Homo sapiens(Human) -> XP_005270808.1 Homo sapiens gap junction protein beta 5 (GJB5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu04849
Clone ID Related Accession (Same CDS sequence)	XM_005270751.3 , NM_005268.3 , NM_005268.4 , XM_005270751.2
Accession Version	XM_005270751.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	gap junction beta-5 protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005270751.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACTGGA GTATCTTTGA GGGACTCCTG AGTGGGGTCA ACAAGTACTC CACAGCCTTT 
GGGCGCATCT GGCTGTCTCT GGTCTTCATC TTCCGCGTGC TGGTGTACCT GGTGACGGCC 
GAGCGTGTGT GGAGTGATGA CCACAAGGAC TTCGACTGCA ATACTCGCCA GCCCGGCTGC 
TCCAACGTCT GCTTTGATGA GTTCTTCCCT GTGTCCCATG TGCGCCTCTG GGCCCTGCAG 
CTTATCCTGG TGACATGCCC CTCACTGCTC GTGGTCATGC ACGTGGCCTA CCGGGAGGTT 
CAGGAGAAGA GGCACCGAGA AGCCCATGGG GAGAACAGTG GGCGCCTCTA CCTGAACCCC 
GGCAAGAAGC GGGGTGGGCT CTGGTGGACA TATGTCTGCA GCCTAGTGTT CAAGGCGAGC 
GTGGACATCG CCTTTCTCTA TGTGTTCCAC TCATTCTACC CCAAATATAT CCTCCCTCCT 
GTGGTCAAGT GCCACGCAGA TCCATGTCCC AATATAGTGG ACTGCTTCAT CTCCAAGCCC 
TCAGAGAAGA ACATTTTCAC CCTCTTCATG GTGGCCACAG CTGCCATCTG CATCCTGCTC 
AACCTCGTGG AGCTCATCTA CCTGGTGAGC AAGAGATGCC ACGAGTGCCT GGCAGCAAGG 
AAAGCTCAAG CCATGTGCAC AGGTCATCAC CCCCACGGTA CCACCTCTTC CTGCAAACAA 
GACGACCTCC TTTCGGGTGA CCTCATCTTT CTGGGCTCAG ACAGTCATCC TCCTCTCTTA 
CCAGACCGCC CCCGAGACCA TGTGAAGAAA ACCATCTTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005270808.1
CDS	441..1262
Translation	MNWSIFEGLLSGVNKYSTAFGRIWLSLVFIFRVLVYLVTAERVWSDDHKDFDCNTRQPGCSNVCFDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREVQEKRHREAHGENSGRLYLNPGKKRGGLWWTYVCSLVFKASVDIAFLYVFHSFYPKYILPPVVKCHADPCPNIVDCFISKPSEKNIFTLFMVATAAICILLNLVELIYLVSKRCHECLAARKAQAMCTGHHPHGTTSSCKQDDLLSGDLIFLGSDSHPPLLPDRPRDHVKKTIL

Target ORF information:

RefSeq Version	XM_005270751.3
Organism	Homo sapiens(human)
Definition	Homo sapiens gap junction protein beta 5 (GJB5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005270751.3

ORF Insert Sequence:

ATGAACTGGA GTATCTTTGA GGGACTCCTG AGTGGGGTCA ACAAGTACTC CACAGCCTTT 
GGGCGCATCT GGCTGTCTCT GGTCTTCATC TTCCGCGTGC TGGTGTACCT GGTGACGGCC 
GAGCGTGTGT GGAGTGATGA CCACAAGGAC TTCGACTGCA ATACTCGCCA GCCCGGCTGC 
TCCAACGTCT GCTTTGATGA GTTCTTCCCT GTGTCCCATG TGCGCCTCTG GGCCCTGCAG 
CTTATCCTGG TGACATGCCC CTCACTGCTC GTGGTCATGC ACGTGGCCTA CCGGGAGGTT 
CAGGAGAAGA GGCACCGAGA AGCCCATGGG GAGAACAGTG GGCGCCTCTA CCTGAACCCC 
GGCAAGAAGC GGGGTGGGCT CTGGTGGACA TATGTCTGCA GCCTAGTGTT CAAGGCGAGC 
GTGGACATCG CCTTTCTCTA TGTGTTCCAC TCATTCTACC CCAAATATAT CCTCCCTCCT 
GTGGTCAAGT GCCACGCAGA TCCATGTCCC AATATAGTGG ACTGCTTCAT CTCCAAGCCC 
TCAGAGAAGA ACATTTTCAC CCTCTTCATG GTGGCCACAG CTGCCATCTG CATCCTGCTC 
AACCTCGTGG AGCTCATCTA CCTGGTGAGC AAGAGATGCC ACGAGTGCCT GGCAGCAAGG 
AAAGCTCAAG CCATGTGCAC AGGTCATCAC CCCCACGGTA CCACCTCTTC CTGCAAACAA 
GACGACCTCC TTTCGGGTGA CCTCATCTTT CTGGGCTCAG ACAGTCATCC TCCTCTCTTA 
CCAGACCGCC CCCGAGACCA TGTGAAGAAA ACCATCTTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GJB5 ( XM_005270751.2 ) cDNA ORF clone, Homo sapiens(Human) -> XP_005270808.1 Homo sapiens gap junction protein, beta 5, 31.1kDa (GJB5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu04849
Clone ID Related Accession (Same CDS sequence)	XM_005270751.3 , NM_005268.3 , NM_005268.4 , XM_005270751.2
Accession Version	XM_005270751.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1426003200000
Organism	Homo sapiens(Human)
Product	gap junction beta-5 protein isoform X1
Comment

ATGAACTGGA GTATCTTTGA GGGACTCCTG AGTGGGGTCA ACAAGTACTC CACAGCCTTT 
GGGCGCATCT GGCTGTCTCT GGTCTTCATC TTCCGCGTGC TGGTGTACCT GGTGACGGCC 
GAGCGTGTGT GGAGTGATGA CCACAAGGAC TTCGACTGCA ATACTCGCCA GCCCGGCTGC 
TCCAACGTCT GCTTTGATGA GTTCTTCCCT GTGTCCCATG TGCGCCTCTG GGCCCTGCAG 
CTTATCCTGG TGACATGCCC CTCACTGCTC GTGGTCATGC ACGTGGCCTA CCGGGAGGTT 
CAGGAGAAGA GGCACCGAGA AGCCCATGGG GAGAACAGTG GGCGCCTCTA CCTGAACCCC 
GGCAAGAAGC GGGGTGGGCT CTGGTGGACA TATGTCTGCA GCCTAGTGTT CAAGGCGAGC 
GTGGACATCG CCTTTCTCTA TGTGTTCCAC TCATTCTACC CCAAATATAT CCTCCCTCCT 
GTGGTCAAGT GCCACGCAGA TCCATGTCCC AATATAGTGG ACTGCTTCAT CTCCAAGCCC 
TCAGAGAAGA ACATTTTCAC CCTCTTCATG GTGGCCACAG CTGCCATCTG CATCCTGCTC 
AACCTCGTGG AGCTCATCTA CCTGGTGAGC AAGAGATGCC ACGAGTGCCT GGCAGCAAGG 
AAAGCTCAAG CCATGTGCAC AGGTCATCAC CCCCACGGTA CCACCTCTTC CTGCAAACAA 
GACGACCTCC TTTCGGGTGA CCTCATCTTT CTGGGCTCAG ACAGTCATCC TCCTCTCTTA 
CCAGACCGCC CCCGAGACCA TGTGAAGAAA ACCATCTTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005270808.1
Translation	MNWSIFEGLLSGVNKYSTAFGRIWLSLVFIFRVLVYLVTAERVWSDDHKDFDCNTRQPGCSNVCFDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREVQEKRHREAHGENSGRLYLNPGKKRGGLWWTYVCSLVFKASVDIAFLYVFHSFYPKYILPPVVKCHADPCPNIVDCFISKPSEKNIFTLFMVATAAICILLNLVELIYLVSKRCHECLAARKAQAMCTGHHPHGTTSSCKQDDLLSGDLIFLGSDSHPPLLPDRPRDHVKKTIL

Target ORF information:

RefSeq Version	XM_005270751.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens gap junction protein, beta 5, 31.1kDa (GJB5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005270751.2

ORF Insert Sequence:

ATGAACTGGA GTATCTTTGA GGGACTCCTG AGTGGGGTCA ACAAGTACTC CACAGCCTTT 
GGGCGCATCT GGCTGTCTCT GGTCTTCATC TTCCGCGTGC TGGTGTACCT GGTGACGGCC 
GAGCGTGTGT GGAGTGATGA CCACAAGGAC TTCGACTGCA ATACTCGCCA GCCCGGCTGC 
TCCAACGTCT GCTTTGATGA GTTCTTCCCT GTGTCCCATG TGCGCCTCTG GGCCCTGCAG 
CTTATCCTGG TGACATGCCC CTCACTGCTC GTGGTCATGC ACGTGGCCTA CCGGGAGGTT 
CAGGAGAAGA GGCACCGAGA AGCCCATGGG GAGAACAGTG GGCGCCTCTA CCTGAACCCC 
GGCAAGAAGC GGGGTGGGCT CTGGTGGACA TATGTCTGCA GCCTAGTGTT CAAGGCGAGC 
GTGGACATCG CCTTTCTCTA TGTGTTCCAC TCATTCTACC CCAAATATAT CCTCCCTCCT 
GTGGTCAAGT GCCACGCAGA TCCATGTCCC AATATAGTGG ACTGCTTCAT CTCCAAGCCC 
TCAGAGAAGA ACATTTTCAC CCTCTTCATG GTGGCCACAG CTGCCATCTG CATCCTGCTC 
AACCTCGTGG AGCTCATCTA CCTGGTGAGC AAGAGATGCC ACGAGTGCCT GGCAGCAAGG 
AAAGCTCAAG CCATGTGCAC AGGTCATCAC CCCCACGGTA CCACCTCTTC CTGCAAACAA 
GACGACCTCC TTTCGGGTGA CCTCATCTTT CTGGGCTCAG ACAGTCATCC TCCTCTCTTA 
CCAGACCGCC CCCGAGACCA TGTGAAGAAA ACCATCTTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Connexin 31.1 degradation requires the Clathrin-mediated autophagy in NSCLC cell H1299.
Journal of cellular and molecular medicine19(1)257-64(2015 Jan)
Zhu X,Ruan Z,Yang X,Chu K,Wu H,Li Y,Huang Y

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