| Gene Symbol | RNF11 |
| Entrez Gene ID | 26994 |
| Full Name | ring finger protein 11 |
| Synonyms | CGI-123,SID1669 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
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RNF11 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following RNF11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RNF11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu29196 Clone ID Related Accession (Same CDS sequence) NM_014372.5 , NM_014372.4 Accession Version NM_014372.5 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 465bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1570550400000 Organism Homo sapiens(human) Product RING finger protein 11 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB265274.1, BC047654.1, BC036670.1, BC020964.2, DB564333.1 and AA224090.1. On Nov 23, 2018 this sequence version replaced NM_014372.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.213058.1, SRR1660803.151881.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000242719.4/ ENSP00000242719.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421ATGGGGAACT GCCTCAAATC CCCCACCTCG GATGACATCT CCCTGCTTCA CGAGTCTCAG
TCCGACCGGG CTAGCTTTGG CGAGGGGACG GAGCCGGATC AGGAGCCGCC GCCGCCATAT
CAGGAACAAG TTCCAGTTCC AGTCTACCAC CCAACACCTA GCCAGACTCG GCTAGCAACT
CAGCTGACTG AAGAGGAACA AATTAGGATA GCTCAAAGAA TAGGTCTTAT ACAACATCTG
CCTAAAGGAG TTTATGACCC TGGAAGAGAT GGATCAGAAA AAAAGATCCG GGAGTGTGTG
ATCTGTATGA TGGACTTTGT TTATGGGGAC CCAATTCGAT TTCTGCCGTG CATGCACATC
TATCACCTGG ACTGTATAGA TGACTGGTTG ATGAGATCCT TCACGTGCCC CTCCTGCATG
GAGCCAGTTG ATGCAGCACT GCTTTCATCC TATGAGACTA ATTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_055187.1 CDS 485..949 Translation 
Target ORF information:
RefSeq Version NM_014372.5 Organism Homo sapiens(human) Definition Homo sapiens ring finger protein 11 (RNF11), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_014372.5
ORF Insert Sequence:
1
61
121
181
241
301
361
421ATGGGGAACT GCCTCAAATC CCCCACCTCG GATGACATCT CCCTGCTTCA CGAGTCTCAG
TCCGACCGGG CTAGCTTTGG CGAGGGGACG GAGCCGGATC AGGAGCCGCC GCCGCCATAT
CAGGAACAAG TTCCAGTTCC AGTCTACCAC CCAACACCTA GCCAGACTCG GCTAGCAACT
CAGCTGACTG AAGAGGAACA AATTAGGATA GCTCAAAGAA TAGGTCTTAT ACAACATCTG
CCTAAAGGAG TTTATGACCC TGGAAGAGAT GGATCAGAAA AAAAGATCCG GGAGTGTGTG
ATCTGTATGA TGGACTTTGT TTATGGGGAC CCAATTCGAT TTCTGCCGTG CATGCACATC
TATCACCTGG ACTGTATAGA TGACTGGTTG ATGAGATCCT TCACGTGCCC CTCCTGCATG
GAGCCAGTTG ATGCAGCACT GCTTTCATCC TATGAGACTA ATTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu29196 Clone ID Related Accession (Same CDS sequence) NM_014372.5 , NM_014372.4 Accession Version NM_014372.4 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 465bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1511625600000 Organism Homo sapiens(human) Product RING finger protein 11 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB265274.1, BC047654.1, BC036670.1, BC020964.2, DB564333.1 and AA224090.1. On Aug 31, 2007 this sequence version replaced NM_014372.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.213058.1, SRR1660803.151881.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421ATGGGGAACT GCCTCAAATC CCCCACCTCG GATGACATCT CCCTGCTTCA CGAGTCTCAG
TCCGACCGGG CTAGCTTTGG CGAGGGGACG GAGCCGGATC AGGAGCCGCC GCCGCCATAT
CAGGAACAAG TTCCAGTTCC AGTCTACCAC CCAACACCTA GCCAGACTCG GCTAGCAACT
CAGCTGACTG AAGAGGAACA AATTAGGATA GCTCAAAGAA TAGGTCTTAT ACAACATCTG
CCTAAAGGAG TTTATGACCC TGGAAGAGAT GGATCAGAAA AAAAGATCCG GGAGTGTGTG
ATCTGTATGA TGGACTTTGT TTATGGGGAC CCAATTCGAT TTCTGCCGTG CATGCACATC
TATCACCTGG ACTGTATAGA TGACTGGTTG ATGAGATCCT TCACGTGCCC CTCCTGCATG
GAGCCAGTTG ATGCAGCACT GCTTTCATCC TATGAGACTA ATTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_055187.1 CDS 485..949 Translation
Target ORF information:
RefSeq Version NM_014372.4 Organism Homo sapiens(human) Definition Homo sapiens ring finger protein 11 (RNF11), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_014372.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421ATGGGGAACT GCCTCAAATC CCCCACCTCG GATGACATCT CCCTGCTTCA CGAGTCTCAG
TCCGACCGGG CTAGCTTTGG CGAGGGGACG GAGCCGGATC AGGAGCCGCC GCCGCCATAT
CAGGAACAAG TTCCAGTTCC AGTCTACCAC CCAACACCTA GCCAGACTCG GCTAGCAACT
CAGCTGACTG AAGAGGAACA AATTAGGATA GCTCAAAGAA TAGGTCTTAT ACAACATCTG
CCTAAAGGAG TTTATGACCC TGGAAGAGAT GGATCAGAAA AAAAGATCCG GGAGTGTGTG
ATCTGTATGA TGGACTTTGT TTATGGGGAC CCAATTCGAT TTCTGCCGTG CATGCACATC
TATCACCTGG ACTGTATAGA TGACTGGTTG ATGAGATCCT TCACGTGCCC CTCCTGCATG
GAGCCAGTTG ATGCAGCACT GCTTTCATCC TATGAGACTA ATTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
The RING domain of RING Finger 11 (RNF11) protein binds Ubc13 and inhibits formation of polyubiquitin chains.
FEBS letters592(8)1434-1444(2018 04)
Budhidarmo R,Zhu J,Middleton AJ,Day CL
Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW
RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling.
The Journal of biological chemistry292(18)7435-7451(2017 05)
Malonis RJ,Fu W,Jelcic MJ,Thompson M,Canter BS,Tsikitis M,Esteva FJ,Sánchez I
The endosomal transcriptional regulator RNF11 integrates degradation and transport of EGFR.
The Journal of cell biology215(4)543-558(2016 Nov)
Scharaw S,Iskar M,Ori A,Boncompain G,Laketa V,Poser I,Lundberg E,Perez F,Beck M,Bork P,Pepperkok R
RNF11 is a GGA protein cargo and acts as a molecular adaptor for GGA3 ubiquitination mediated by Itch.
Oncogene34(26)3377-90(2015 Jun)
Santonico E,Mattioni A,Panni S,Belleudi F,Mattei M,Torrisi MR,Cesareni G,Castagnoli L
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