| Gene Symbol | MSTN |
| Entrez Gene ID | 2660 |
| Full Name | myostatin |
| Synonyms | GDF8,MSLHP |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016]. |
| Disorder MIM: | |
| Disorder Html: | Muscle hypertrophy, 614160 (3) |
- REAGENT SERVICES Hot!
-
PRODUCTS
-
Most Popular Reagents
-
Instruments
-
Antibodies
-
ELISA Kits
-
Protein Electrophoresis and Blotting
-
Protein and Antibody Purification
-
Recombinant Proteins
-
Molecular Biology
-
Stable Cell Lines
-
Cell Isolation and Activation
-
IVD Raw Materials
-
Therapy Applications
-
Resources
-
![AmMag™ Quatro Automated Plasmid Purification]()
AmMag™ Quatro automated plasmid purification
-
![Anti-Camelid VHH]()
MonoRab™ Anti-VHH Antibodies
-
![ELISA Kits]()
ELISA Kits
-
![Precast Gels]()
SurePAGE™ Precast Gels
-
![Quatro ProAb Automated Protein and Antibody Purification System]()
AmMag™ Quatro ProAb Automated Protein and Antibody Purification System
-
![Target Proteins]()
Target Proteins
-
![AmMag™ Quatro Automated Plasmid Purification]()
AmMag™ Quatro automated plasmid purification
-
![Stable Cell Lines]()
Stable Cell Lines
-
![Cell Isolation and Activation]()
Cell Isolation and Activation
-
![Quick
Order]()
Quick Order
-
![Quick
Order]()
Quick Order
- APPLICATIONS
- RESOURCES
- ABOUT US
MSTN cDNA ORF clone, Homo sapiens(human)
-
Gene
-
Clones
gRNAs
The following MSTN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MSTN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
Online Only Promotion
Up to 50% OFF! Starting
from $49/clone
-
Reference Sequences (Refseq)
CloneID OHu22435 Clone ID Related Accession (Same CDS sequence) NM_005259.2 , NM_005259.3 Accession Version NM_005259.2 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1128bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1549641600000 Organism Homo sapiens(human) Product growth/differentiation factor 8 preproprotein Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF104922.1 and BX093210.1. This sequence is a reference standard in the RefSeqGene project. On Jun 22, 2007 this sequence version replaced NM_005259.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF104922.1, SRR1660803.79751.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144, SAMEA2467148 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081ATGCAAAAAC TGCAACTCTG TGTTTATATT TACCTGTTTA TGCTGATTGT TGCTGGTCCA
GTGGATCTAA ATGAGAACAG TGAGCAAAAA GAAAATGTGG AAAAAGAGGG GCTGTGTAAT
GCATGTACTT GGAGACAAAA CACTAAATCT TCAAGAATAG AAGCCATTAA GATACAAATC
CTCAGTAAAC TTCGTCTGGA AACAGCTCCT AACATCAGCA AAGATGTTAT AAGACAACTT
TTACCCAAAG CTCCTCCACT CCGGGAACTG ATTGATCAGT ATGATGTCCA GAGGGATGAC
AGCAGCGATG GCTCTTTGGA AGATGACGAT TATCACGCTA CAACGGAAAC AATCATTACC
ATGCCTACAG AGTCTGATTT TCTAATGCAA GTGGATGGAA AACCCAAATG TTGCTTCTTT
AAATTTAGCT CTAAAATACA ATACAATAAA GTAGTAAAGG CCCAACTATG GATATATTTG
AGACCCGTCG AGACTCCTAC AACAGTGTTT GTGCAAATCC TGAGACTCAT CAAACCTATG
AAAGACGGTA CAAGGTATAC TGGAATCCGA TCTCTGAAAC TTGACATGAA CCCAGGCACT
GGTATTTGGC AGAGCATTGA TGTGAAGACA GTGTTGCAAA ATTGGCTCAA ACAACCTGAA
TCCAACTTAG GCATTGAAAT AAAAGCTTTA GATGAGAATG GTCATGATCT TGCTGTAACC
TTCCCAGGAC CAGGAGAAGA TGGGCTGAAT CCGTTTTTAG AGGTCAAGGT AACAGACACA
CCAAAAAGAT CCAGAAGGGA TTTTGGTCTT GACTGTGATG AGCACTCAAC AGAATCACGA
TGCTGTCGTT ACCCTCTAAC TGTGGATTTT GAAGCTTTTG GATGGGATTG GATTATCGCT
CCTAAAAGAT ATAAGGCCAA TTACTGCTCT GGAGAGTGTG AATTTGTATT TTTACAAAAA
TATCCTCATA CTCATCTGGT ACACCAAGCA AACCCCAGAG GTTCAGCAGG CCCTTGCTGT
ACTCCCACAA AGATGTCTCC AATTAATATG CTATATTTTA ATGGCAAAGA ACAAATAATA
TATGGGAAAA TTCCAGCGAT GGTAGTAGAC CGCTGTGGGT GCTCATGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_005250.1 CDS 134..1261 Translation 
Target ORF information:
RefSeq Version NM_005259.2 Organism Homo sapiens(human) Definition Homo sapiens myostatin (MSTN), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_005259.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081ATGCAAAAAC TGCAACTCTG TGTTTATATT TACCTGTTTA TGCTGATTGT TGCTGGTCCA
GTGGATCTAA ATGAGAACAG TGAGCAAAAA GAAAATGTGG AAAAAGAGGG GCTGTGTAAT
GCATGTACTT GGAGACAAAA CACTAAATCT TCAAGAATAG AAGCCATTAA GATACAAATC
CTCAGTAAAC TTCGTCTGGA AACAGCTCCT AACATCAGCA AAGATGTTAT AAGACAACTT
TTACCCAAAG CTCCTCCACT CCGGGAACTG ATTGATCAGT ATGATGTCCA GAGGGATGAC
AGCAGCGATG GCTCTTTGGA AGATGACGAT TATCACGCTA CAACGGAAAC AATCATTACC
ATGCCTACAG AGTCTGATTT TCTAATGCAA GTGGATGGAA AACCCAAATG TTGCTTCTTT
AAATTTAGCT CTAAAATACA ATACAATAAA GTAGTAAAGG CCCAACTATG GATATATTTG
AGACCCGTCG AGACTCCTAC AACAGTGTTT GTGCAAATCC TGAGACTCAT CAAACCTATG
AAAGACGGTA CAAGGTATAC TGGAATCCGA TCTCTGAAAC TTGACATGAA CCCAGGCACT
GGTATTTGGC AGAGCATTGA TGTGAAGACA GTGTTGCAAA ATTGGCTCAA ACAACCTGAA
TCCAACTTAG GCATTGAAAT AAAAGCTTTA GATGAGAATG GTCATGATCT TGCTGTAACC
TTCCCAGGAC CAGGAGAAGA TGGGCTGAAT CCGTTTTTAG AGGTCAAGGT AACAGACACA
CCAAAAAGAT CCAGAAGGGA TTTTGGTCTT GACTGTGATG AGCACTCAAC AGAATCACGA
TGCTGTCGTT ACCCTCTAAC TGTGGATTTT GAAGCTTTTG GATGGGATTG GATTATCGCT
CCTAAAAGAT ATAAGGCCAA TTACTGCTCT GGAGAGTGTG AATTTGTATT TTTACAAAAA
TATCCTCATA CTCATCTGGT ACACCAAGCA AACCCCAGAG GTTCAGCAGG CCCTTGCTGT
ACTCCCACAA AGATGTCTCC AATTAATATG CTATATTTTA ATGGCAAAGA ACAAATAATA
TATGGGAAAA TTCCAGCGAT GGTAGTAGAC CGCTGTGGGT GCTCATGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu22435 Clone ID Related Accession (Same CDS sequence) NM_005259.2 , NM_005259.3 Accession Version NM_005259.3 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1128bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577808000000 Organism Homo sapiens(human) Product growth/differentiation factor 8 preproprotein Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF104922.1 and BX093210.1. On May 17, 2019 this sequence version replaced NM_005259.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF104922.1, AK291524.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000260950.5/ ENSP00000260950.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081ATGCAAAAAC TGCAACTCTG TGTTTATATT TACCTGTTTA TGCTGATTGT TGCTGGTCCA
GTGGATCTAA ATGAGAACAG TGAGCAAAAA GAAAATGTGG AAAAAGAGGG GCTGTGTAAT
GCATGTACTT GGAGACAAAA CACTAAATCT TCAAGAATAG AAGCCATTAA GATACAAATC
CTCAGTAAAC TTCGTCTGGA AACAGCTCCT AACATCAGCA AAGATGTTAT AAGACAACTT
TTACCCAAAG CTCCTCCACT CCGGGAACTG ATTGATCAGT ATGATGTCCA GAGGGATGAC
AGCAGCGATG GCTCTTTGGA AGATGACGAT TATCACGCTA CAACGGAAAC AATCATTACC
ATGCCTACAG AGTCTGATTT TCTAATGCAA GTGGATGGAA AACCCAAATG TTGCTTCTTT
AAATTTAGCT CTAAAATACA ATACAATAAA GTAGTAAAGG CCCAACTATG GATATATTTG
AGACCCGTCG AGACTCCTAC AACAGTGTTT GTGCAAATCC TGAGACTCAT CAAACCTATG
AAAGACGGTA CAAGGTATAC TGGAATCCGA TCTCTGAAAC TTGACATGAA CCCAGGCACT
GGTATTTGGC AGAGCATTGA TGTGAAGACA GTGTTGCAAA ATTGGCTCAA ACAACCTGAA
TCCAACTTAG GCATTGAAAT AAAAGCTTTA GATGAGAATG GTCATGATCT TGCTGTAACC
TTCCCAGGAC CAGGAGAAGA TGGGCTGAAT CCGTTTTTAG AGGTCAAGGT AACAGACACA
CCAAAAAGAT CCAGAAGGGA TTTTGGTCTT GACTGTGATG AGCACTCAAC AGAATCACGA
TGCTGTCGTT ACCCTCTAAC TGTGGATTTT GAAGCTTTTG GATGGGATTG GATTATCGCT
CCTAAAAGAT ATAAGGCCAA TTACTGCTCT GGAGAGTGTG AATTTGTATT TTTACAAAAA
TATCCTCATA CTCATCTGGT ACACCAAGCA AACCCCAGAG GTTCAGCAGG CCCTTGCTGT
ACTCCCACAA AGATGTCTCC AATTAATATG CTATATTTTA ATGGCAAAGA ACAAATAATA
TATGGGAAAA TTCCAGCGAT GGTAGTAGAC CGCTGTGGGT GCTCATGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_005250.1 CDS 134..1261 Translation
Target ORF information:
RefSeq Version NM_005259.3 Organism Homo sapiens(human) Definition Homo sapiens myostatin (MSTN), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_005259.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081ATGCAAAAAC TGCAACTCTG TGTTTATATT TACCTGTTTA TGCTGATTGT TGCTGGTCCA
GTGGATCTAA ATGAGAACAG TGAGCAAAAA GAAAATGTGG AAAAAGAGGG GCTGTGTAAT
GCATGTACTT GGAGACAAAA CACTAAATCT TCAAGAATAG AAGCCATTAA GATACAAATC
CTCAGTAAAC TTCGTCTGGA AACAGCTCCT AACATCAGCA AAGATGTTAT AAGACAACTT
TTACCCAAAG CTCCTCCACT CCGGGAACTG ATTGATCAGT ATGATGTCCA GAGGGATGAC
AGCAGCGATG GCTCTTTGGA AGATGACGAT TATCACGCTA CAACGGAAAC AATCATTACC
ATGCCTACAG AGTCTGATTT TCTAATGCAA GTGGATGGAA AACCCAAATG TTGCTTCTTT
AAATTTAGCT CTAAAATACA ATACAATAAA GTAGTAAAGG CCCAACTATG GATATATTTG
AGACCCGTCG AGACTCCTAC AACAGTGTTT GTGCAAATCC TGAGACTCAT CAAACCTATG
AAAGACGGTA CAAGGTATAC TGGAATCCGA TCTCTGAAAC TTGACATGAA CCCAGGCACT
GGTATTTGGC AGAGCATTGA TGTGAAGACA GTGTTGCAAA ATTGGCTCAA ACAACCTGAA
TCCAACTTAG GCATTGAAAT AAAAGCTTTA GATGAGAATG GTCATGATCT TGCTGTAACC
TTCCCAGGAC CAGGAGAAGA TGGGCTGAAT CCGTTTTTAG AGGTCAAGGT AACAGACACA
CCAAAAAGAT CCAGAAGGGA TTTTGGTCTT GACTGTGATG AGCACTCAAC AGAATCACGA
TGCTGTCGTT ACCCTCTAAC TGTGGATTTT GAAGCTTTTG GATGGGATTG GATTATCGCT
CCTAAAAGAT ATAAGGCCAA TTACTGCTCT GGAGAGTGTG AATTTGTATT TTTACAAAAA
TATCCTCATA CTCATCTGGT ACACCAAGCA AACCCCAGAG GTTCAGCAGG CCCTTGCTGT
ACTCCCACAA AGATGTCTCC AATTAATATG CTATATTTTA ATGGCAAAGA ACAAATAATA
TATGGGAAAA TTCCAGCGAT GGTAGTAGAC CGCTGTGGGT GCTCATGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
-
PubMed
Myostatin and other musculoskeletal markers in lung transplant recipients.
Clinical and experimental medicine19(1)77-85(2019 Feb)
Kerschan-Schindl K,Ebenbichler G,Gruther W,Föger-Samwald U,Kudlacek S,Patsch J,Gleiss A,Jaksch P,Klepetko W,Pietschmann P
Myostatin knockout induces apoptosis in human cervical cancer cells via elevated reactive oxygen species generation.
Redox biology19412-428(2018 10)
Han YQ,Ming SL,Wu HT,Zeng L,Ba G,Li J,Lu WF,Han J,Du QJ,Sun MM,Yang GY,Wang J,Chu BB
Relationship of muscle function to circulating myostatin, follistatin and GDF11 in older women and men.
BMC geriatrics18(1)200(2018 08)
Fife E,Kostka J,Kroc Ł,Guligowska A,Pigłowska M,Sołtysik B,Kaufman-Szymczyk A,Fabianowska-Majewska K,Kostka T
Evaluation of the relationship between muscle mass and serum myostatin levels in chronic hemodialysis patients.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia29(4)809-815(2018 Jul-Aug)
Koyun D,Nergizoglu G,Kir KM
Serum Fas Ligand, Serum Myostatin and Urine TGF-β1 Are Elevated in Autosomal Dominant Polycystic Kidney Disease Patients with Impaired and Preserved Renal Function.
Kidney & blood pressure research43(3)744-754(2018)
Raptis V,Bakogiannis C,Loutradis C,Boutou AK,Sioulis A,Balaskas E,Zebekakis P,Sarafidis PA
-
-
Most Popular Services
-
Services & Products
-
News & Blogs
- Inhibiting Survivin to Survive Cancer
- New Targets in Treating Amyotrophic Lateral Sclerosis (ALS), a Neurodegenerative Disease, Identified Using CRISPR
- “Wai Guo Ren” DNA encoded protein in living cells for the first time
- New Solutions Push the Limits of Engineered T Cells in Solid Tumors
- Hope for cancer patients: an immune-boosting protein without side effects created
- The skin remembers injuries from sticks and stones, can heal recurring wounds faster
- Identifying new therapeutic leads for spinal cord injury using a zebrafish screening platform
- Molecular chainsaw massacre of cancer cells
-
-
-
PubMed
-
