POLDIP2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	POLDIP2
Entrez Gene ID	26073
Full Name	DNA polymerase delta interacting protein 2
Synonyms	PDIP38,POLD4,p38
General protein information	Preferred Names DNA polymerase delta interacting protein 2 Names polymerase delta-interacting protein 2 38 kDa DNA polymerase delta interaction protein polymerase (DNA) delta interacting protein 2 polymerase (DNA-directed), delta interacting protein 2 polymerase delta interacting protein 38
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q11.2
Summary	This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit, as well as with proliferating cell nuclear antigen. The encoded protein maybe play a role in the ability of the replication fork to bypass DNA lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].
Disorder MIM:	611519

mRNA and Protein(s)

mRNA	Protein	Name
NM_015584.5	NP_056399.1	polymerase delta-interacting protein 2 isoform 1
NM_001290145.1	NP_001277074.1	polymerase delta-interacting protein 2 isoform 2
NM_015584.4	NP_056399.1	polymerase delta-interacting protein 2 isoform 1

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001153	XP_322007.4
Homo sapiens (human)	POLDIP2	NP_056399.1
Caenorhabditis elegans (roundworm)	tag-307	NP_498703.2
Gallus gallus (chicken)	TSR1	XP_003642452.1
Pan troglodytes (chimpanzee)	POLDIP2	XP_003315593.1
Macaca mulatta (Rhesus monkey)	POLDIP2	XP_001106573.1
Xenopus tropicalis (tropical clawed frog)	poldip2	NP_001017098.1
Danio rerio (zebrafish)	poldip2	NP_997879.1
Canis lupus familiaris (dog)	POLDIP2	NP_001240832.1
Bos taurus (cattle)	POLDIP2	NP_001091572.1
Mus musculus (house mouse)	Poldip2	NP_080665.1
Drosophila melanogaster (fruit fly)	CG12162	NP_649540.1

Gene Ontology
Bibliography

Related articles in PubMed

PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching.
Tsuda M, Ogawa S, Ooka M, Kobayashi K, Hirota K, Wakasugi M, Matsunaga T, Sakuma T, Yamamoto T, Chikuma S, Sasanuma H, Debatisse M, Doherty AJ, Fuchs RP, Takeda S
PloS one14(3)e0213383(2019)

NOX4 (NADPH Oxidase 4) and Poldip2 (Polymerase δ-Interacting Protein 2) Induce Filamentous Actin Oxidation and Promote Its Interaction With Vinculin During Integrin-Mediated Cell Adhesion.
Vukelic S, Xu Q, Seidel-Rogol B, Faidley EA, Dikalova AE, Hilenski LL, Jorde U, Poole LB, Lassègue B, Zhang G, Griendling KK
Arteriosclerosis, thrombosis, and vascular biology38(10)2423-2434(2018 10)

Knockdown of POLDIP2 suppresses tumor growth and invasion capacity and is linked to unfavorable transformation ability and metastatic feature in non-small cell lung cancer.
Chen YC, Kuo CC, Chian CF, Tzao C, Chang SY, Shih YL, Lin YW, Yu MH, Su HY
Experimental cell research368(1)42-49(2018 07)

Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer.
Paredes F, Sheldon K, Lassègue B, Williams HC, Faidley EA, Benavides GA, Torres G, Sanhueza-Olivares F, Yeligar SM, Griendling KK, Darley-Usmar V, San Martin A
Proceedings of the National Academy of Sciences of the United States of America115(8)1789-1794(2018 02)

PolDIP2 interacts with human PrimPol and enhances its DNA polymerase activities.
Guilliam TA, Bailey LJ, Brissett NC, Doherty AJ
Nucleic acids research44(7)3317-29(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following POLDIP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the POLDIP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23851	NM_001290145.1 Latest version!	Homo sapiens DNA polymerase delta interacting protein 2 (POLDIP2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu23261	NM_015584.5 Latest version!	Homo sapiens DNA polymerase delta interacting protein 2 (POLDIP2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu23261	NM_015584.4	Homo sapiens DNA polymerase delta interacting protein 2 (POLDIP2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

POLDIP2 ( NM_001290145.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001277074.1 Homo sapiens DNA polymerase delta interacting protein 2 (POLDIP2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu23851
Clone ID Related Accession (Same CDS sequence)	NM_001290145.1
Accession Version	NM_001290145.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1053bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Homo sapiens(human)
Product	polymerase delta-interacting protein 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY130221.1, BC000655.2, BM809398.1, BG150599.1 and AI917975.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK293707.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCCT GTACAGCCCG GCGGGCCCTG GCCGTGGGCA GCCGCTGGTG GTCCCGGTCG 
CTGACTGGGG CCCGGTGGCC AAGGCCGCTC TGTGCGGCGG CCGGAGCTGG AGCCTTCTCG 
CCAGCGTCGA CCACGACGAC GCGGAGGCAC CTCTCGTCCC GAAACCGACC AGAGGGCAAA 
GTGTTGGAGA CAGTTGGTGT GTTTGAGGTG CCAAAACAGA ATGGAAAATA TGAGACCGGG 
CAGGCCAGAC TGTATGACCG GGATGTGGCT TCTGCAGCTC CAGAAAAAGC AGAGAACCCT 
GCTGGCCATG GCTCCAAGGA GGTGAAAGGC AAAACTCACA CTTACTATCA GGTGCTGATT 
GATGCTCGTG ACTGCCCACA TATATCTCAG AGATCTCAGA CAGAAGCTGT GACCTTCTTG 
GCTAACCATG ATGACAGTCG GGCCCTCTAT GCCATCCCAG GCTTGGACTA TGTCAGCCAT 
GAAGACATCC TCCCCTACAC CTCCACTGAT CAGGTTCCCA TCCAACATGA ACTCTTTGAA 
AGATTTCTTC TGTATGACCA GACAAAAGCA CCTCCTTTTG TGGCTCGGGA GACGCTAAGG 
GCCTGGCAAG AGAAGAATCA CCCCTGGCTG GAGCTCTCCG ATGTTCATCG GGAAACAACT 
GAGAACATAC GTGTCACTGT CATCCCCTTC TACATGGGCA TGAGGGAAGC CCAGAATTCC 
CACGTGTACT GGTGGCGCTA CTGTATCCGT TTGGAGAACC TTGACAGTGA TGTGGTACAG 
CTCCGGGAGC GGCACTGGAG GATATTCAGT CTCTCTGGCA CCTTGGAGAC AGTGCGAGGC 
CGAGGGGTAG TGGGCAGGGA ACCAGTGTTA TCCAAGGAGC AGCCTGCGTT CCAGTATAGC 
AGCCACGTCT CGCTGCAGGC TTCCAGTGGG CACATGTGGG GCACGTTCCG CTTTGAAAGA 
CCTGATGGCT CCCACTTTGA TGTTCGGATT CCTCCCTTCT CCCTGGAAAG CAATAAAGAT 
GAGAAGACAC CACCCTCAGG CCTTCACTGG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001277074.1
CDS	142..1194
Translation	MAACTARRALAVGSRWWSRSLTGARWPRPLCAAAGAGAFSPASTTTTRRHLSSRNRPEGKVLETVGVFEVPKQNGKYETGQARLYDRDVASAAPEKAENPAGHGSKEVKGKTHTYYQVLIDARDCPHISQRSQTEAVTFLANHDDSRALYAIPGLDYVSHEDILPYTSTDQVPIQHELFERFLLYDQTKAPPFVARETLRAWQEKNHPWLELSDVHRETTENIRVTVIPFYMGMREAQNSHVYWWRYCIRLENLDSDVVQLRERHWRIFSLSGTLETVRGRGVVGREPVLSKEQPAFQYSSHVSLQASSGHMWGTFRFERPDGSHFDVRIPPFSLESNKDEKTPPSGLHW

Target ORF information:

RefSeq Version	NM_001290145.1
Organism	Homo sapiens(human)
Definition	Homo sapiens DNA polymerase delta interacting protein 2 (POLDIP2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001290145.1

ORF Insert Sequence:

ATGGCAGCCT GTACAGCCCG GCGGGCCCTG GCCGTGGGCA GCCGCTGGTG GTCCCGGTCG 
CTGACTGGGG CCCGGTGGCC AAGGCCGCTC TGTGCGGCGG CCGGAGCTGG AGCCTTCTCG 
CCAGCGTCGA CCACGACGAC GCGGAGGCAC CTCTCGTCCC GAAACCGACC AGAGGGCAAA 
GTGTTGGAGA CAGTTGGTGT GTTTGAGGTG CCAAAACAGA ATGGAAAATA TGAGACCGGG 
CAGGCCAGAC TGTATGACCG GGATGTGGCT TCTGCAGCTC CAGAAAAAGC AGAGAACCCT 
GCTGGCCATG GCTCCAAGGA GGTGAAAGGC AAAACTCACA CTTACTATCA GGTGCTGATT 
GATGCTCGTG ACTGCCCACA TATATCTCAG AGATCTCAGA CAGAAGCTGT GACCTTCTTG 
GCTAACCATG ATGACAGTCG GGCCCTCTAT GCCATCCCAG GCTTGGACTA TGTCAGCCAT 
GAAGACATCC TCCCCTACAC CTCCACTGAT CAGGTTCCCA TCCAACATGA ACTCTTTGAA 
AGATTTCTTC TGTATGACCA GACAAAAGCA CCTCCTTTTG TGGCTCGGGA GACGCTAAGG 
GCCTGGCAAG AGAAGAATCA CCCCTGGCTG GAGCTCTCCG ATGTTCATCG GGAAACAACT 
GAGAACATAC GTGTCACTGT CATCCCCTTC TACATGGGCA TGAGGGAAGC CCAGAATTCC 
CACGTGTACT GGTGGCGCTA CTGTATCCGT TTGGAGAACC TTGACAGTGA TGTGGTACAG 
CTCCGGGAGC GGCACTGGAG GATATTCAGT CTCTCTGGCA CCTTGGAGAC AGTGCGAGGC 
CGAGGGGTAG TGGGCAGGGA ACCAGTGTTA TCCAAGGAGC AGCCTGCGTT CCAGTATAGC 
AGCCACGTCT CGCTGCAGGC TTCCAGTGGG CACATGTGGG GCACGTTCCG CTTTGAAAGA 
CCTGATGGCT CCCACTTTGA TGTTCGGATT CCTCCCTTCT CCCTGGAAAG CAATAAAGAT 
GAGAAGACAC CACCCTCAGG CCTTCACTGG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

POLDIP2 ( NM_015584.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_056399.1 Homo sapiens DNA polymerase delta interacting protein 2 (POLDIP2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23261
Clone ID Related Accession (Same CDS sequence)	NM_015584.5 , NM_015584.4
Accession Version	NM_015584.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1107bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577548800000
Organism	Homo sapiens(human)
Product	polymerase delta-interacting protein 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY130221.1, BC000655.2, BM809398.1 and BG150599.1. On Nov 23, 2018 this sequence version replaced NM_015584.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.225224.1, SRR1803611.252494.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000540200.6/ ENSP00000475924.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGCCT GTACAGCCCG GCGGGCCCTG GCCGTGGGCA GCCGCTGGTG GTCCCGGTCG 
CTGACTGGGG CCCGGTGGCC AAGGCCGCTC TGTGCGGCGG CCGGAGCTGG AGCCTTCTCG 
CCAGCGTCGA CCACGACGAC GCGGAGGCAC CTCTCGTCCC GAAACCGACC AGAGGGCAAA 
GTGTTGGAGA CAGTTGGTGT GTTTGAGGTG CCAAAACAGA ATGGAAAATA TGAGACCGGG 
CAGCTTTTCC TTCATAGCAT TTTTGGCTAC CGAGGTGTCG TCCTGTTTCC CTGGCAGGCC 
AGACTGTATG ACCGGGATGT GGCTTCTGCA GCTCCAGAAA AAGCAGAGAA CCCTGCTGGC 
CATGGCTCCA AGGAGGTGAA AGGCAAAACT CACACTTACT ATCAGGTGCT GATTGATGCT 
CGTGACTGCC CACATATATC TCAGAGATCT CAGACAGAAG CTGTGACCTT CTTGGCTAAC 
CATGATGACA GTCGGGCCCT CTATGCCATC CCAGGCTTGG ACTATGTCAG CCATGAAGAC 
ATCCTCCCCT ACACCTCCAC TGATCAGGTT CCCATCCAAC ATGAACTCTT TGAAAGATTT 
CTTCTGTATG ACCAGACAAA AGCACCTCCT TTTGTGGCTC GGGAGACGCT AAGGGCCTGG 
CAAGAGAAGA ATCACCCCTG GCTGGAGCTC TCCGATGTTC ATCGGGAAAC AACTGAGAAC 
ATACGTGTCA CTGTCATCCC CTTCTACATG GGCATGAGGG AAGCCCAGAA TTCCCACGTG 
TACTGGTGGC GCTACTGTAT CCGTTTGGAG AACCTTGACA GTGATGTGGT ACAGCTCCGG 
GAGCGGCACT GGAGGATATT CAGTCTCTCT GGCACCTTGG AGACAGTGCG AGGCCGAGGG 
GTAGTGGGCA GGGAACCAGT GTTATCCAAG GAGCAGCCTG CGTTCCAGTA TAGCAGCCAC 
GTCTCGCTGC AGGCTTCCAG TGGGCACATG TGGGGCACGT TCCGCTTTGA AAGACCTGAT 
GGCTCCCACT TTGATGTTCG GATTCCTCCC TTCTCCCTGG AAAGCAATAA AGATGAGAAG 
ACACCACCCT CAGGCCTTCA CTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056399.1
CDS	80..1186
Translation	MAACTARRALAVGSRWWSRSLTGARWPRPLCAAAGAGAFSPASTTTTRRHLSSRNRPEGKVLETVGVFEVPKQNGKYETGQLFLHSIFGYRGVVLFPWQARLYDRDVASAAPEKAENPAGHGSKEVKGKTHTYYQVLIDARDCPHISQRSQTEAVTFLANHDDSRALYAIPGLDYVSHEDILPYTSTDQVPIQHELFERFLLYDQTKAPPFVARETLRAWQEKNHPWLELSDVHRETTENIRVTVIPFYMGMREAQNSHVYWWRYCIRLENLDSDVVQLRERHWRIFSLSGTLETVRGRGVVGREPVLSKEQPAFQYSSHVSLQASSGHMWGTFRFERPDGSHFDVRIPPFSLESNKDEKTPPSGLHW

Target ORF information:

RefSeq Version	NM_015584.5
Organism	Homo sapiens(human)
Definition	Homo sapiens DNA polymerase delta interacting protein 2 (POLDIP2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015584.5

ORF Insert Sequence:

ATGGCAGCCT GTACAGCCCG GCGGGCCCTG GCCGTGGGCA GCCGCTGGTG GTCCCGGTCG 
CTGACTGGGG CCCGGTGGCC AAGGCCGCTC TGTGCGGCGG CCGGAGCTGG AGCCTTCTCG 
CCAGCGTCGA CCACGACGAC GCGGAGGCAC CTCTCGTCCC GAAACCGACC AGAGGGCAAA 
GTGTTGGAGA CAGTTGGTGT GTTTGAGGTG CCAAAACAGA ATGGAAAATA TGAGACCGGG 
CAGCTTTTCC TTCATAGCAT TTTTGGCTAC CGAGGTGTCG TCCTGTTTCC CTGGCAGGCC 
AGACTGTATG ACCGGGATGT GGCTTCTGCA GCTCCAGAAA AAGCAGAGAA CCCTGCTGGC 
CATGGCTCCA AGGAGGTGAA AGGCAAAACT CACACTTACT ATCAGGTGCT GATTGATGCT 
CGTGACTGCC CACATATATC TCAGAGATCT CAGACAGAAG CTGTGACCTT CTTGGCTAAC 
CATGATGACA GTCGGGCCCT CTATGCCATC CCAGGCTTGG ACTATGTCAG CCATGAAGAC 
ATCCTCCCCT ACACCTCCAC TGATCAGGTT CCCATCCAAC ATGAACTCTT TGAAAGATTT 
CTTCTGTATG ACCAGACAAA AGCACCTCCT TTTGTGGCTC GGGAGACGCT AAGGGCCTGG 
CAAGAGAAGA ATCACCCCTG GCTGGAGCTC TCCGATGTTC ATCGGGAAAC AACTGAGAAC 
ATACGTGTCA CTGTCATCCC CTTCTACATG GGCATGAGGG AAGCCCAGAA TTCCCACGTG 
TACTGGTGGC GCTACTGTAT CCGTTTGGAG AACCTTGACA GTGATGTGGT ACAGCTCCGG 
GAGCGGCACT GGAGGATATT CAGTCTCTCT GGCACCTTGG AGACAGTGCG AGGCCGAGGG 
GTAGTGGGCA GGGAACCAGT GTTATCCAAG GAGCAGCCTG CGTTCCAGTA TAGCAGCCAC 
GTCTCGCTGC AGGCTTCCAG TGGGCACATG TGGGGCACGT TCCGCTTTGA AAGACCTGAT 
GGCTCCCACT TTGATGTTCG GATTCCTCCC TTCTCCCTGG AAAGCAATAA AGATGAGAAG 
ACACCACCCT CAGGCCTTCA CTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

POLDIP2 ( NM_015584.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_056399.1 Homo sapiens DNA polymerase delta interacting protein 2 (POLDIP2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23261
Clone ID Related Accession (Same CDS sequence)	NM_015584.5 , NM_015584.4
Accession Version	NM_015584.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1107bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506873600000
Organism	Homo sapiens(human)
Product	polymerase delta-interacting protein 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY130221.1, BC000655.2, BM809398.1, BG150599.1 and AI917975.1. On Feb 27, 2014 this sequence version replaced NM_015584.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.235438.1, SRR1660809.79856.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCCT GTACAGCCCG GCGGGCCCTG GCCGTGGGCA GCCGCTGGTG GTCCCGGTCG 
CTGACTGGGG CCCGGTGGCC AAGGCCGCTC TGTGCGGCGG CCGGAGCTGG AGCCTTCTCG 
CCAGCGTCGA CCACGACGAC GCGGAGGCAC CTCTCGTCCC GAAACCGACC AGAGGGCAAA 
GTGTTGGAGA CAGTTGGTGT GTTTGAGGTG CCAAAACAGA ATGGAAAATA TGAGACCGGG 
CAGCTTTTCC TTCATAGCAT TTTTGGCTAC CGAGGTGTCG TCCTGTTTCC CTGGCAGGCC 
AGACTGTATG ACCGGGATGT GGCTTCTGCA GCTCCAGAAA AAGCAGAGAA CCCTGCTGGC 
CATGGCTCCA AGGAGGTGAA AGGCAAAACT CACACTTACT ATCAGGTGCT GATTGATGCT 
CGTGACTGCC CACATATATC TCAGAGATCT CAGACAGAAG CTGTGACCTT CTTGGCTAAC 
CATGATGACA GTCGGGCCCT CTATGCCATC CCAGGCTTGG ACTATGTCAG CCATGAAGAC 
ATCCTCCCCT ACACCTCCAC TGATCAGGTT CCCATCCAAC ATGAACTCTT TGAAAGATTT 
CTTCTGTATG ACCAGACAAA AGCACCTCCT TTTGTGGCTC GGGAGACGCT AAGGGCCTGG 
CAAGAGAAGA ATCACCCCTG GCTGGAGCTC TCCGATGTTC ATCGGGAAAC AACTGAGAAC 
ATACGTGTCA CTGTCATCCC CTTCTACATG GGCATGAGGG AAGCCCAGAA TTCCCACGTG 
TACTGGTGGC GCTACTGTAT CCGTTTGGAG AACCTTGACA GTGATGTGGT ACAGCTCCGG 
GAGCGGCACT GGAGGATATT CAGTCTCTCT GGCACCTTGG AGACAGTGCG AGGCCGAGGG 
GTAGTGGGCA GGGAACCAGT GTTATCCAAG GAGCAGCCTG CGTTCCAGTA TAGCAGCCAC 
GTCTCGCTGC AGGCTTCCAG TGGGCACATG TGGGGCACGT TCCGCTTTGA AAGACCTGAT 
GGCTCCCACT TTGATGTTCG GATTCCTCCC TTCTCCCTGG AAAGCAATAA AGATGAGAAG 
ACACCACCCT CAGGCCTTCA CTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056399.1
CDS	142..1248
Translation	MAACTARRALAVGSRWWSRSLTGARWPRPLCAAAGAGAFSPASTTTTRRHLSSRNRPEGKVLETVGVFEVPKQNGKYETGQLFLHSIFGYRGVVLFPWQARLYDRDVASAAPEKAENPAGHGSKEVKGKTHTYYQVLIDARDCPHISQRSQTEAVTFLANHDDSRALYAIPGLDYVSHEDILPYTSTDQVPIQHELFERFLLYDQTKAPPFVARETLRAWQEKNHPWLELSDVHRETTENIRVTVIPFYMGMREAQNSHVYWWRYCIRLENLDSDVVQLRERHWRIFSLSGTLETVRGRGVVGREPVLSKEQPAFQYSSHVSLQASSGHMWGTFRFERPDGSHFDVRIPPFSLESNKDEKTPPSGLHW

Target ORF information:

RefSeq Version	NM_015584.4
Organism	Homo sapiens(human)
Definition	Homo sapiens DNA polymerase delta interacting protein 2 (POLDIP2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015584.4

ORF Insert Sequence:

ATGGCAGCCT GTACAGCCCG GCGGGCCCTG GCCGTGGGCA GCCGCTGGTG GTCCCGGTCG 
CTGACTGGGG CCCGGTGGCC AAGGCCGCTC TGTGCGGCGG CCGGAGCTGG AGCCTTCTCG 
CCAGCGTCGA CCACGACGAC GCGGAGGCAC CTCTCGTCCC GAAACCGACC AGAGGGCAAA 
GTGTTGGAGA CAGTTGGTGT GTTTGAGGTG CCAAAACAGA ATGGAAAATA TGAGACCGGG 
CAGCTTTTCC TTCATAGCAT TTTTGGCTAC CGAGGTGTCG TCCTGTTTCC CTGGCAGGCC 
AGACTGTATG ACCGGGATGT GGCTTCTGCA GCTCCAGAAA AAGCAGAGAA CCCTGCTGGC 
CATGGCTCCA AGGAGGTGAA AGGCAAAACT CACACTTACT ATCAGGTGCT GATTGATGCT 
CGTGACTGCC CACATATATC TCAGAGATCT CAGACAGAAG CTGTGACCTT CTTGGCTAAC 
CATGATGACA GTCGGGCCCT CTATGCCATC CCAGGCTTGG ACTATGTCAG CCATGAAGAC 
ATCCTCCCCT ACACCTCCAC TGATCAGGTT CCCATCCAAC ATGAACTCTT TGAAAGATTT 
CTTCTGTATG ACCAGACAAA AGCACCTCCT TTTGTGGCTC GGGAGACGCT AAGGGCCTGG 
CAAGAGAAGA ATCACCCCTG GCTGGAGCTC TCCGATGTTC ATCGGGAAAC AACTGAGAAC 
ATACGTGTCA CTGTCATCCC CTTCTACATG GGCATGAGGG AAGCCCAGAA TTCCCACGTG 
TACTGGTGGC GCTACTGTAT CCGTTTGGAG AACCTTGACA GTGATGTGGT ACAGCTCCGG 
GAGCGGCACT GGAGGATATT CAGTCTCTCT GGCACCTTGG AGACAGTGCG AGGCCGAGGG 
GTAGTGGGCA GGGAACCAGT GTTATCCAAG GAGCAGCCTG CGTTCCAGTA TAGCAGCCAC 
GTCTCGCTGC AGGCTTCCAG TGGGCACATG TGGGGCACGT TCCGCTTTGA AAGACCTGAT 
GGCTCCCACT TTGATGTTCG GATTCCTCCC TTCTCCCTGG AAAGCAATAA AGATGAGAAG 
ACACCACCCT CAGGCCTTCA CTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching.
PloS one14(3)e0213383(2019)
Tsuda M,Ogawa S,Ooka M,Kobayashi K,Hirota K,Wakasugi M,Matsunaga T,Sakuma T,Yamamoto T,Chikuma S,Sasanuma H,Debatisse M,Doherty AJ,Fuchs RP,Takeda S

NOX4 (NADPH Oxidase 4) and Poldip2 (Polymerase δ-Interacting Protein 2) Induce Filamentous Actin Oxidation and Promote Its Interaction With Vinculin During Integrin-Mediated Cell Adhesion.
Arteriosclerosis, thrombosis, and vascular biology38(10)2423-2434(2018 10)
Vukelic S,Xu Q,Seidel-Rogol B,Faidley EA,Dikalova AE,Hilenski LL,Jorde U,Poole LB,Lassègue B,Zhang G,Griendling KK

Knockdown of POLDIP2 suppresses tumor growth and invasion capacity and is linked to unfavorable transformation ability and metastatic feature in non-small cell lung cancer.
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Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer.
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POLDIP2 cDNA ORF clone, Homo sapiens(human)

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