ARHGAP8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ARHGAP8
Entrez Gene ID	23779
Full Name	Rho GTPase activating protein 8
Synonyms	BPGAP1,PP610
General protein information	Preferred Names Rho GTPase activating protein 8 Names rho GTPase-activating protein 8 BCH domain-containing Cdc42GAP-like protein BNIP-2 and Cdc42GAP homology domain-containing, proline-rich and Cdc42GAP-like protein subtype-1 rho-type GTPase-activating protein 8
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q13.31
Summary	This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010].
Disorder MIM:	609405

mRNA and Protein(s)

mRNA	Protein	Name
NM_001017526.1	NP_001017526.1	rho GTPase-activating protein 8 isoform 1
NM_001198726.1	NP_001185655.1	rho GTPase-activating protein 8 isoform 3
NM_181335.2	NP_851852.2	rho GTPase-activating protein 8 isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	ARHGAP8	NP_851852.2
Mus musculus (house mouse)	Arhgap8	NP_082731.2
Gallus gallus (chicken)	ARHGAP8	NP_001191318.1
Canis lupus familiaris (dog)	ARHGAP8	NP_001191334.1
Pan troglodytes (chimpanzee)	ARHGAP8	XP_003317351.1
Homo sapiens (human)	PRR5-ARHGAP8	NP_851851.2
Rattus norvegicus (Norway rat)	Arhgap8	NP_001004242.1
Xenopus tropicalis (tropical clawed frog)	arhgap8	NP_001016951.1

Gene Ontology
Bibliography

Related articles in PubMed

Bipolar disorder with binge eating behavior: a genome-wide association study implicates PRR5-ARHGAP8.
McElroy SL, Winham SJ, Cuellar-Barboza AB, Colby CL, Ho AM, Sicotte H, Larrabee BR, Crow S, Frye MA, Biernacka JM
Translational psychiatry8(1)40(2018 02)

BPGAP1 spatially integrates JNK/ERK signaling crosstalk in oncogenesis.
Jiang T, Pan CQ, Low BC
Oncogene36(22)3178-3192(2017 06)

Bipolar disorder with comorbid binge eating history: a genome-wide association study implicates APOB.
Winham SJ, Cuellar-Barboza AB, McElroy SL, Oliveros A, Crow S, Colby CL, Choi DS, Chauhan M, Frye MA, Biernacka JM
Journal of affective disorders165151-8(2014 Aug)

Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
Ludwig KU, Mangold E, Herms S, Nowak S, Reutter H, Paul A, Becker J, Herberz R, AlChawa T, Nasser E, Böhmer AC, Mattheisen M, Alblas MA, Barth S, Kluck N, Lauster C, Braumann B, Reich RH, Hemprich A, Pötzsch S, Blaumeiser B, Daratsianos N, Kreusch T, Murray JC, Marazita ML, Ruczinski I, Scott AF, Beaty TH, Kramer FJ, Wienker TF, Steegers-Theunissen RP, Rubini M, Mossey PA, Hoffmann P, Lange C, Cichon S, Propping P, Knapp M, Nöthen MM
Nature genetics44(9)968-71(2012 Sep)

Family-based genome-wide association study of frontal θ oscillations identifies potassium channel gene KCNJ6.
Kang SJ, Rangaswamy M, Manz N, Wang JC, Wetherill L, Hinrichs T, Almasy L, Brooks A, Chorlian DB, Dick D, Hesselbrock V, Kramer J, Kuperman S, Nurnberger J Jr, Rice J, Schuckit M, Tischfield J, Bierut LJ, Edenberg HJ, Goate A, Foroud T, Porjesz B
Genes, brain, and behavior11(6)712-9(2012 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ARHGAP8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ARHGAP8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31147	NM_181335.2 Latest version!	Homo sapiens Rho GTPase activating protein 8 (ARHGAP8), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu55639	NM_001198726.1 Latest version!	Homo sapiens Rho GTPase activating protein 8 (ARHGAP8), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu30869	NM_001017526.1 Latest version!	Homo sapiens Rho GTPase activating protein 8 (ARHGAP8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ARHGAP8 ( NM_181335.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_851852.2 Homo sapiens Rho GTPase activating protein 8 (ARHGAP8), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu31147
Clone ID Related Accession (Same CDS sequence)	NM_181335.2
Accession Version	NM_181335.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1302bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1564761600000
Organism	Homo sapiens(human)
Product	rho GTPase-activating protein 8 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK001306.1, AK022305.1, BC010490.2 and Z83838.2. On May 19, 2005 this sequence version replaced NM_181335.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding reigon, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: SRR1803614.115378.1, BC048280.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGGCC AGGATCCTGC GCTGAGCACG AGTCACCCGT TCTACGACGT GGCCAGACAT 
GGCATTCTGC AGGTGGCAGG GGATGACCGC TTTGGAAGAC GTGTTGTCAC GTTCAGCTGC 
TGCCGGATGC CACCCTCCCA CGAGCTGGAC CACCAGCGGC TGCTGGAGTA TTTGAAGTAC 
ACACTGGACC AATACGTTGA GAACGATTAT ACCATCGTCT ATTTCCACTA CGGGCTGAAC 
AGCCGGAACA AGCCTTCCCT GGGCTGGCTC CAGAGCGCAT ACAAGGAGTT CGATAGGAAG 
TACAAGAAGA ACTTGAAGGC CCTCTACGTG GTGCACCCCA CCAGCTTCAT CAAGGTCCTG 
TGGAACATCT TGAAGCCCCT CATCAGTCAC AAGTTTGGGA AGAAAGTCAT CTATTTCAAC 
TACCTGAGTG AGCTCCACGA ACACCTTAAA TACGACCAGC TGGTCATCCC TCCCGAAGTT 
TTGCGGTACG ATGAGAAGCT CCAGAGCCTG CACGAGGGCC GGACGCCGCC TCCCACCAAG 
ACACCACCGC CGCGGCCCCC GCTGCCCACA CAGCAGTTTG GCGTCAGTCT GCAATACCTC 
AAAGACAAAA ATCAAGGCGA ACTCATCCCC CCTGTGCTGA GGTTCACAGT GACGTACCTG 
AGAGAGAAAG GCCTGCGCAC CGAGGGCCTG TTCCGGAGAT CCGCCAGCGT GCAGACCGTC 
CGCGAGATCC AGAGGCTCTA CAACCAAGGG AAGCCCGTGA ACTTTGACGA CTACGGGGAC 
ATTCACATCC CTGCCGTGAT CCTGAAGACC TTCCTGCGAG AGCTGCCCCA GCCGCTTCTG 
ACCTTCCAGG CCTACGAGCA GATTCTCGGG ATCACCTGTG TGGAGAGCAG CCTGCGTGTC 
ACTGGCTGCC GCCAGATCTT ACGGAGCCTC CCAGAGCACA ACTACGTCGT CCTCCGCTAC 
CTCATGGGCT TCCTGCATGC GGTGTCCCGG GAGAGCATCT TCAACAAAAT GAACAGCTCT 
AACCTGGCCT GTGTCTTCGG GCTGAATTTG ATCTGGCCAT CCCAGGGGGT CTCCTCCCTG 
AGTGCCCTTG TGCCCCTGAA CATGTTCACT GAACTGCTGA TCGAGTACTA TGAAAAGATC 
TTCAGCACCC CGGAGGCACC TGGGGAGCAC GGCCTGGCAC CATGGGAACA GGGGAGCAGG 
GCAGCCCCTT TGCAGGAGGC TGTGCCACGG ACACAAGCCA CGGGCCTCAC CAAGCCTACC 
CTACCTCCGA GTCCCCTGAT GGCAGCCAGA AGACGTCTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_851852.2
CDS	142..1443
Translation	MAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYLKYTLDQYVENDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRKYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHLKYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL

Target ORF information:

RefSeq Version	NM_181335.2
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho GTPase activating protein 8 (ARHGAP8), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181335.2

ORF Insert Sequence:

ATGGCTGGCC AGGATCCTGC GCTGAGCACG AGTCACCCGT TCTACGACGT GGCCAGACAT 
GGCATTCTGC AGGTGGCAGG GGATGACCGC TTTGGAAGAC GTGTTGTCAC GTTCAGCTGC 
TGCCGGATGC CACCCTCCCA CGAGCTGGAC CACCAGCGGC TGCTGGAGTA TTTGAAGTAC 
ACACTGGACC AATACGTTGA GAACGATTAT ACCATCGTCT ATTTCCACTA CGGGCTGAAC 
AGCCGGAACA AGCCTTCCCT GGGCTGGCTC CAGAGCGCAT ACAAGGAGTT CGATAGGAAG 
TACAAGAAGA ACTTGAAGGC CCTCTACGTG GTGCACCCCA CCAGCTTCAT CAAGGTCCTG 
TGGAACATCT TGAAGCCCCT CATCAGTCAC AAGTTTGGGA AGAAAGTCAT CTATTTCAAC 
TACCTGAGTG AGCTCCACGA ACACCTTAAA TACGACCAGC TGGTCATCCC TCCCGAAGTT 
TTGCGGTACG ATGAGAAGCT CCAGAGCCTG CACGAGGGCC GGACGCCGCC TCCCACCAAG 
ACACCACCGC CGCGGCCCCC GCTGCCCACA CAGCAGTTTG GCGTCAGTCT GCAATACCTC 
AAAGACAAAA ATCAAGGCGA ACTCATCCCC CCTGTGCTGA GGTTCACAGT GACGTACCTG 
AGAGAGAAAG GCCTGCGCAC CGAGGGCCTG TTCCGGAGAT CCGCCAGCGT GCAGACCGTC 
CGCGAGATCC AGAGGCTCTA CAACCAAGGG AAGCCCGTGA ACTTTGACGA CTACGGGGAC 
ATTCACATCC CTGCCGTGAT CCTGAAGACC TTCCTGCGAG AGCTGCCCCA GCCGCTTCTG 
ACCTTCCAGG CCTACGAGCA GATTCTCGGG ATCACCTGTG TGGAGAGCAG CCTGCGTGTC 
ACTGGCTGCC GCCAGATCTT ACGGAGCCTC CCAGAGCACA ACTACGTCGT CCTCCGCTAC 
CTCATGGGCT TCCTGCATGC GGTGTCCCGG GAGAGCATCT TCAACAAAAT GAACAGCTCT 
AACCTGGCCT GTGTCTTCGG GCTGAATTTG ATCTGGCCAT CCCAGGGGGT CTCCTCCCTG 
AGTGCCCTTG TGCCCCTGAA CATGTTCACT GAACTGCTGA TCGAGTACTA TGAAAAGATC 
TTCAGCACCC CGGAGGCACC TGGGGAGCAC GGCCTGGCAC CATGGGAACA GGGGAGCAGG 
GCAGCCCCTT TGCAGGAGGC TGTGCCACGG ACACAAGCCA CGGGCCTCAC CAAGCCTACC 
CTACCTCCGA GTCCCCTGAT GGCAGCCAGA AGACGTCTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARHGAP8 ( NM_001198726.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001185655.1 Homo sapiens Rho GTPase activating protein 8 (ARHGAP8), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu55639
Clone ID Related Accession (Same CDS sequence)	NM_001198726.1
Accession Version	NM_001198726.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1564761600000
Organism	Homo sapiens(human)
Product	rho GTPase-activating protein 8 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK001306.1, BC067824.1, AI284954.1 and AW673723.1. Transcript Variant: This variant (3) lacks both an alternate in-frame exon in the central coding region and an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BC067824.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGGCC AGGATCCTGC GCTGAGCACG AGTCACCCGT TCTACGACGT GGCCAGACAT 
GGCATTCTGC AGGTGGCAGG GGATGACCGC TTTGGAAGAC GTGTTGTCAC GTTCAGCTGC 
TGCCGGATGC CACCCTCCCA CGAGCTGGAC CACCAGCGGC TGCTGGAGTA TTTGAAGTAC 
ACACTGGACC AATACGTTGA GAACGATTAT ACCATCGTCT ATTTCCACTA CGGGCTGAAC 
AGCCGGAACA AGCCTTCCCT GGGCTGGCTC CAGAGCGCAT ACAAGGAGTT CGATAGGAAG 
TACAAGAAGA ACTTGAAGGC CCTCTACGTG GTGCACCCCA CCAGCTTCAT CAAGGTCCTG 
TGGAACATCT TGAAGCCCCT CATCAGTCAC AAGTTTGGGA AGAAAGTCAT CTATTTCAAC 
TACCTGAGTG AGCTCCACGA ACACCTTAAA TACGACCAGC TGGTCATCCC TCCCGAAGTT 
TTGCGGTACG ATGAGAAGCT CCAGAGCCTG CACGAGGGCC GGACGCCGCC TCCCACCAAG 
ACACCACCGC CGCGGCCCCC GCTGCCCACA CAGCAGTTTG GCGTCAGTCT GCAATACCTC 
AAAGACAAAA ATCAAGGCGA ACTCATCCCC CCTGTGCTGA GGTTCACAGT GACGTACCTG 
AGAGAGAAAG GCCTGCGCAC CGAGGGCCTG TTCCGGAGAT CCGCCAGCGT GCAGACCGTC 
CGCGAGATCC AGAGGCTCTA CAACCAAGGG AAGCCCGTGA ACTTTGACGA CTACGGGGAC 
ATTCACATCC CTGCCGTGAT CCTGAAGACC TTCCTGCGAG AGCTGCCCCA GCCGCTTCTG 
ACCTTCCAGG CCTACGAGCA GATTCTCGGG ATCACCTGTG TCCCGGGAGA GCATCTTCAA 
CAAAATGAAC AGCTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001185655.1
CDS	142..1059
Translation	MAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYLKYTLDQYVENDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRKYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHLKYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVPGEHLQQNEQL

Target ORF information:

RefSeq Version	NM_001198726.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho GTPase activating protein 8 (ARHGAP8), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001198726.1

ORF Insert Sequence:

ATGGCTGGCC AGGATCCTGC GCTGAGCACG AGTCACCCGT TCTACGACGT GGCCAGACAT 
GGCATTCTGC AGGTGGCAGG GGATGACCGC TTTGGAAGAC GTGTTGTCAC GTTCAGCTGC 
TGCCGGATGC CACCCTCCCA CGAGCTGGAC CACCAGCGGC TGCTGGAGTA TTTGAAGTAC 
ACACTGGACC AATACGTTGA GAACGATTAT ACCATCGTCT ATTTCCACTA CGGGCTGAAC 
AGCCGGAACA AGCCTTCCCT GGGCTGGCTC CAGAGCGCAT ACAAGGAGTT CGATAGGAAG 
TACAAGAAGA ACTTGAAGGC CCTCTACGTG GTGCACCCCA CCAGCTTCAT CAAGGTCCTG 
TGGAACATCT TGAAGCCCCT CATCAGTCAC AAGTTTGGGA AGAAAGTCAT CTATTTCAAC 
TACCTGAGTG AGCTCCACGA ACACCTTAAA TACGACCAGC TGGTCATCCC TCCCGAAGTT 
TTGCGGTACG ATGAGAAGCT CCAGAGCCTG CACGAGGGCC GGACGCCGCC TCCCACCAAG 
ACACCACCGC CGCGGCCCCC GCTGCCCACA CAGCAGTTTG GCGTCAGTCT GCAATACCTC 
AAAGACAAAA ATCAAGGCGA ACTCATCCCC CCTGTGCTGA GGTTCACAGT GACGTACCTG 
AGAGAGAAAG GCCTGCGCAC CGAGGGCCTG TTCCGGAGAT CCGCCAGCGT GCAGACCGTC 
CGCGAGATCC AGAGGCTCTA CAACCAAGGG AAGCCCGTGA ACTTTGACGA CTACGGGGAC 
ATTCACATCC CTGCCGTGAT CCTGAAGACC TTCCTGCGAG AGCTGCCCCA GCCGCTTCTG 
ACCTTCCAGG CCTACGAGCA GATTCTCGGG ATCACCTGTG TCCCGGGAGA GCATCTTCAA 
CAAAATGAAC AGCTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARHGAP8 ( NM_001017526.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001017526.1 Homo sapiens Rho GTPase activating protein 8 (ARHGAP8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu30869
Clone ID Related Accession (Same CDS sequence)	NM_001017526.1
Accession Version	NM_001017526.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1395bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1564761600000
Organism	Homo sapiens(human)
Product	rho GTPase-activating protein 8 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK001306.1, AK022305.1, BC010490.2 and Z83838.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK001306.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGGCC AGGATCCTGC GCTGAGCACG AGTCACCCGT TCTACGACGT GGCCAGACAT 
GGCATTCTGC AGGTGGCAGG GGATGACCGC TTTGGAAGAC GTGTTGTCAC GTTCAGCTGC 
TGCCGGATGC CACCCTCCCA CGAGCTGGAC CACCAGCGGC TGCTGGAGTA TTTGAAGTAC 
ACACTGGACC AATACGTTGA GAACGATTAT ACCATCGTCT ATTTCCACTA CGGGCTGAAC 
AGCCGGAACA AGCCTTCCCT GGGCTGGCTC CAGAGCGCAT ACAAGGAGTT CGATAGGAAA 
GACGGGGATC TCACTATGTG GCCCAGGCTG GTCTCGAACT CCAAGCTCAA GCGATCCTCC 
CACCTCAGCC TCCCAAAGTA CTGGGATTAC AGGTACAAGA AGAACTTGAA GGCCCTCTAC 
GTGGTGCACC CCACCAGCTT CATCAAGGTC CTGTGGAACA TCTTGAAGCC CCTCATCAGT 
CACAAGTTTG GGAAGAAAGT CATCTATTTC AACTACCTGA GTGAGCTCCA CGAACACCTT 
AAATACGACC AGCTGGTCAT CCCTCCCGAA GTTTTGCGGT ACGATGAGAA GCTCCAGAGC 
CTGCACGAGG GCCGGACGCC GCCTCCCACC AAGACACCAC CGCCGCGGCC CCCGCTGCCC 
ACACAGCAGT TTGGCGTCAG TCTGCAATAC CTCAAAGACA AAAATCAAGG CGAACTCATC 
CCCCCTGTGC TGAGGTTCAC AGTGACGTAC CTGAGAGAGA AAGGCCTGCG CACCGAGGGC 
CTGTTCCGGA GATCCGCCAG CGTGCAGACC GTCCGCGAGA TCCAGAGGCT CTACAACCAA 
GGGAAGCCCG TGAACTTTGA CGACTACGGG GACATTCACA TCCCTGCCGT GATCCTGAAG 
ACCTTCCTGC GAGAGCTGCC CCAGCCGCTT CTGACCTTCC AGGCCTACGA GCAGATTCTC 
GGGATCACCT GTGTGGAGAG CAGCCTGCGT GTCACTGGCT GCCGCCAGAT CTTACGGAGC 
CTCCCAGAGC ACAACTACGT CGTCCTCCGC TACCTCATGG GCTTCCTGCA TGCGGTGTCC 
CGGGAGAGCA TCTTCAACAA AATGAACAGC TCTAACCTGG CCTGTGTCTT CGGGCTGAAT 
TTGATCTGGC CATCCCAGGG GGTCTCCTCC CTGAGTGCCC TTGTGCCCCT GAACATGTTC 
ACTGAACTGC TGATCGAGTA CTATGAAAAG ATCTTCAGCA CCCCGGAGGC ACCTGGGGAG 
CACGGCCTGG CACCATGGGA ACAGGGGAGC AGGGCAGCCC CTTTGCAGGA GGCTGTGCCA 
CGGACACAAG CCACGGGCCT CACCAAGCCT ACCCTACCTC CGAGTCCCCT GATGGCAGCC 
AGAAGACGTC TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001017526.1
CDS	142..1536
Translation	MAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYLKYTLDQYVENDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRKDGDLTMWPRLVSNSKLKRSSHLSLPKYWDYRYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHLKYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL

Target ORF information:

RefSeq Version	NM_001017526.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho GTPase activating protein 8 (ARHGAP8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001017526.1

ORF Insert Sequence:

ATGGCTGGCC AGGATCCTGC GCTGAGCACG AGTCACCCGT TCTACGACGT GGCCAGACAT 
GGCATTCTGC AGGTGGCAGG GGATGACCGC TTTGGAAGAC GTGTTGTCAC GTTCAGCTGC 
TGCCGGATGC CACCCTCCCA CGAGCTGGAC CACCAGCGGC TGCTGGAGTA TTTGAAGTAC 
ACACTGGACC AATACGTTGA GAACGATTAT ACCATCGTCT ATTTCCACTA CGGGCTGAAC 
AGCCGGAACA AGCCTTCCCT GGGCTGGCTC CAGAGCGCAT ACAAGGAGTT CGATAGGAAA 
GACGGGGATC TCACTATGTG GCCCAGGCTG GTCTCGAACT CCAAGCTCAA GCGATCCTCC 
CACCTCAGCC TCCCAAAGTA CTGGGATTAC AGGTACAAGA AGAACTTGAA GGCCCTCTAC 
GTGGTGCACC CCACCAGCTT CATCAAGGTC CTGTGGAACA TCTTGAAGCC CCTCATCAGT 
CACAAGTTTG GGAAGAAAGT CATCTATTTC AACTACCTGA GTGAGCTCCA CGAACACCTT 
AAATACGACC AGCTGGTCAT CCCTCCCGAA GTTTTGCGGT ACGATGAGAA GCTCCAGAGC 
CTGCACGAGG GCCGGACGCC GCCTCCCACC AAGACACCAC CGCCGCGGCC CCCGCTGCCC 
ACACAGCAGT TTGGCGTCAG TCTGCAATAC CTCAAAGACA AAAATCAAGG CGAACTCATC 
CCCCCTGTGC TGAGGTTCAC AGTGACGTAC CTGAGAGAGA AAGGCCTGCG CACCGAGGGC 
CTGTTCCGGA GATCCGCCAG CGTGCAGACC GTCCGCGAGA TCCAGAGGCT CTACAACCAA 
GGGAAGCCCG TGAACTTTGA CGACTACGGG GACATTCACA TCCCTGCCGT GATCCTGAAG 
ACCTTCCTGC GAGAGCTGCC CCAGCCGCTT CTGACCTTCC AGGCCTACGA GCAGATTCTC 
GGGATCACCT GTGTGGAGAG CAGCCTGCGT GTCACTGGCT GCCGCCAGAT CTTACGGAGC 
CTCCCAGAGC ACAACTACGT CGTCCTCCGC TACCTCATGG GCTTCCTGCA TGCGGTGTCC 
CGGGAGAGCA TCTTCAACAA AATGAACAGC TCTAACCTGG CCTGTGTCTT CGGGCTGAAT 
TTGATCTGGC CATCCCAGGG GGTCTCCTCC CTGAGTGCCC TTGTGCCCCT GAACATGTTC 
ACTGAACTGC TGATCGAGTA CTATGAAAAG ATCTTCAGCA CCCCGGAGGC ACCTGGGGAG 
CACGGCCTGG CACCATGGGA ACAGGGGAGC AGGGCAGCCC CTTTGCAGGA GGCTGTGCCA 
CGGACACAAG CCACGGGCCT CACCAAGCCT ACCCTACCTC CGAGTCCCCT GATGGCAGCC 
AGAAGACGTC TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Bipolar disorder with binge eating behavior: a genome-wide association study implicates PRR5-ARHGAP8.
Translational psychiatry8(1)40(2018 02)
McElroy SL,Winham SJ,Cuellar-Barboza AB,Colby CL,Ho AM,Sicotte H,Larrabee BR,Crow S,Frye MA,Biernacka JM

BPGAP1 spatially integrates JNK/ERK signaling crosstalk in oncogenesis.
Oncogene36(22)3178-3192(2017 06)
Jiang T,Pan CQ,Low BC

Bipolar disorder with comorbid binge eating history: a genome-wide association study implicates APOB.
Journal of affective disorders165151-8(2014 Aug)
Winham SJ,Cuellar-Barboza AB,McElroy SL,Oliveros A,Crow S,Colby CL,Choi DS,Chauhan M,Frye MA,Biernacka JM

Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
Nature genetics44(9)968-71(2012 Sep)
Ludwig KU,Mangold E,Herms S,Nowak S,Reutter H,Paul A,Becker J,Herberz R,AlChawa T,Nasser E,Böhmer AC,Mattheisen M,Alblas MA,Barth S,Kluck N,Lauster C,Braumann B,Reich RH,Hemprich A,Pötzsch S,Blaumeiser B,Daratsianos N,Kreusch T,Murray JC,Marazita ML,Ruczinski I,Scott AF,Beaty TH,Kramer FJ,Wienker TF,Steegers-Theunissen RP,Rubini M,Mossey PA,Hoffmann P,Lange C,Cichon S,Propping P,Knapp M,Nöthen MM

Family-based genome-wide association study of frontal θ oscillations identifies potassium channel gene KCNJ6.
Genes, brain, and behavior11(6)712-9(2012 Aug)
Kang SJ,Rangaswamy M,Manz N,Wang JC,Wetherill L,Hinrichs T,Almasy L,Brooks A,Chorlian DB,Dick D,Hesselbrock V,Kramer J,Kuperman S,Nurnberger J Jr,Rice J,Schuckit M,Tischfield J,Bierut LJ,Edenberg HJ,Goate A,Foroud T,Porjesz B

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ARHGAP8 cDNA ORF clone, Homo sapiens(human)

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