LEMD3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LEMD3
Entrez Gene ID	23592
Full Name	LEM domain containing 3
Synonyms	MAN1
General protein information	Preferred Names LEM domain containing 3 Names inner nuclear membrane protein Man1 LEM domain-containing protein 3 LEMD3/MKX fusion integral inner nuclear membrane protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q14.3
Summary	This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.[provided by RefSeq, Nov 2009].
Disorder MIM:	607844
Disorder Html:	Osteopoikilosis with or without melorheostosis, 166700 (3); Buschke-Ollendorff syndrome, 166700 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001167614.2	NP_001161086.1	inner nuclear membrane protein Man1 isoform 2
NM_014319.5	NP_055134.2	inner nuclear membrane protein Man1 isoform 1
NM_014319.4	NP_055134.2	inner nuclear membrane protein Man1 isoform 1
NM_001167614.1	NP_001161086.1	inner nuclear membrane protein Man1 isoform 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LEMD3	XP_005625712.1
Bos taurus (cattle)	LEMD3	NP_001179628.1
Pan troglodytes (chimpanzee)	LEMD3	XP_509197.2
Macaca mulatta (Rhesus monkey)	LEMD3	XP_001116983.1
Mus musculus (house mouse)	Lemd3	NP_001074662.2
Rattus norvegicus (Norway rat)	Lemd3	NP_001177929.1
Gallus gallus (chicken)	LEMD3	XP_416073.3
Danio rerio (zebrafish)	lemd3	NP_001038329.1
Homo sapiens (human)	LEMD3	NP_055134.2
Xenopus tropicalis (tropical clawed frog)	lemd3	NP_001136130.1

Gene Ontology
Bibliography

Related articles in PubMed

Structural basis for receptor-regulated SMAD recognition by MAN1.
Miyazono KI, Ohno Y, Wada H, Ito T, Fukatsu Y, Kurisaki A, Asashima M, Tanokura M
Nucleic acids research46(22)12139-12153(2018 12)

LEM domain-containing protein 3 antagonizes TGFβ-SMAD2/3 signaling in a stiffness-dependent manner in both the nucleus and cytosol.
Chambers DM, Moretti L, Zhang JJ, Cooper SW, Chambers DM, Santangelo PJ, Barker TH
The Journal of biological chemistry293(41)15867-15886(2018 10)

Buschke-Ollendorff syndrome due to a novel LEMD3 mutation - an unusual case of alopecia.
Darr-Foit S, Schliemann S, Schulz S, Elsner P
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG16(3)348-349(2018 Mar)

The Role of the Nuclear Envelope Protein MAN1 in Mesenchymal Stem Cell Differentiation.
Bermeo S, Al-Saedi A, Kassem M, Vidal C, Duque G
Journal of cellular biochemistry118(12)4425-4435(2017 12)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following LEMD3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LEMD3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04065	NM_001167614.2 Latest version!	Homo sapiens LEM domain containing 3 (LEMD3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
OHu19032	NM_014319.5 Latest version!	Homo sapiens LEM domain containing 3 (LEMD3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$643.30 $919.00
View Old Accession Versions >>
OHu19032	NM_014319.4	Homo sapiens LEM domain containing 3 (LEMD3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$459.50-$643.30 $919.00
OHu04065	NM_001167614.1	Homo sapiens LEM domain containing 3 (LEMD3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LEMD3 ( NM_014319.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055134.2 Homo sapiens LEM domain containing 3 (LEMD3), transcript variant 1, mRNA.

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CloneID	OHu19032
Clone ID Related Accession (Same CDS sequence)	NM_014319.5 , NM_014319.4
Accession Version	NM_014319.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2736bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1514390400000
Organism	Homo sapiens(human)
Product	inner nuclear membrane protein Man1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK312473.1, AF112299.2 and BX390128.2. This sequence is a reference standard in the RefSeqGene project. On Nov 10, 2009 this sequence version replaced NM_014319.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.46629.1, SRR1660807.256865.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG CAGCAGCTTC GGCGCCTCAG CAGCTCTCGG ATGAGGAGCT TTTCTCTCAG 
CTCCGCCGTT ACGGCCTGTC TCCCGGACCA GTGACGGAGA GCACCCGCCC GGTCTACCTC 
AAGAAGCTGA AGAAGCTTCG AGAGGAAGAG CAGCAACAGC ACCGGTCAGG GGGCCGCGGC 
AACAAGACGC GGAACAGTAA TAACAATAAC ACGGCAGCCG CCACGGTCGC AGCCGCGGGA 
CCAGCGGCGG CGGCGGCCGC GGGGATGGGG GTCCGGCCGG TCTCGGGCGA CCTCTCCTAC 
TTACGGACTC CTGGGGGCCT GTGCCGAATC TCGGCCTCTG GCCCAGAGAG CCTCCTGGGA 
GGGCCCGGGG GCGCCTCCGC CGCCCCCGCG GCTGGCAGCA AAGTGCTGCT GGGCTTCAGC 
TCGGACGAGT CGGACGTGGA GGCCAGTCCC CGGGACCAGG CCGGCGGCGG CGGGAGGAAA 
GACCGGGCTT CGCTCCAGTA CCGCGGGCTC AAAGCGCCGC CGGCGCCCCT GGCCGCCAGC 
GAGGTGACTA ACAGCAACTC TGCAGAGCGA AGGAAGCCCC ACTCGTGGTG GGGGGCCAGG 
AGGCCGGCGG GCCCCGAGCT GCAGACCCCG CCGGGGAAAG ATGGAGCAGT GGAGGACGAG 
GAAGGGGAGG GAGAGGACGG TGAGGAGAGG GACCCGGAGA CCGAGGAGCC GCTCTGGGCG 
AGCCGGACCG TGAATGGCAG CCGGCTTGTC CCCTACAGCT GCCGGGAAAA CTATTCGGAC 
TCAGAGGAAG AGGACGACGA CGACGTGGCC TCCAGCAGAC AGGTATTAAA GGACGACTCC 
CTTTCCCGGC ATCGGCCCAG ACGAACCCAT AGTAAGCCTC TCCCCCCGCT GACTGCTAAA 
TCGGCCGGCG GCAGGCTGGA GACTTCAGTT CAGGGAGGGG GAGGACTCGC GATGAATGAC 
AGGGCGGCGG CTGCCGGGAG TCTAGACAGG AGCCGAAACC TCGAAGAGGC GGCGGCCGCG 
GAGCAGGGAG GAGGGTGTGA TCAAGTGGAC TCCAGCCCCG TTCCTAGATA CCGTGTTAAC 
GCTAAGAAAC TGACCCCTCT CCTGCCCCCG CCACTTACTG ACATGGACTC AACCTTGGAT 
TCGTCAACAG GCTCCCTTCT GAAAACCAAT AATCATATTG GCGGTGGGGC CTTCAGTGTG 
GACTCCCCCA GGATTTATTC TAACAGTCTC CCTCCCAGTG CGGCGGTGGC CGCCTCTAGT 
TCACTCAGGA TCAATCACGC CAATCATACG GGCTCCAATC ATACCTACCT GAAAAACACA 
TACAACAAAC CGAAGCTTTC CGAACCCGAA GAGGAACTTC TCCAGCAATT TAAACGGGAG 
GAGGTGTCCC CAACAGGGAG TTTCAGTGCC CACTACTTGT CGATGTTTCT CTTAACTGCT 
GCCTGCTTAT TTTTCCTAAT ACTGGGACTG ACTTACCTAG GAATGAGAGG GACAGGAGTA 
TCTGAGGATG GAGAACTCAG CATAGAAAAC CCCTTTGGTG AAACATTTGG AAAAATACAA 
GAAAGTGAAA AAACTCTTAT GATGAACACA TTATATAAGC TTCATGATCG ATTGGCACAG 
CTTGCAGGAG ATCATGAATG TGGCAGTTCT AGTCAAAGAA CGCTTTCTGT TCAAGAGGCA 
GCTGCGTATT TAAAAGATTT AGGTCCTGAA TATGAAGGTA TATTTAACAC TTCATTGCAG 
TGGATCTTAG AAAATGGAAA AGATGTTGGA ATAAGGTGTG TTGGTTTTGG CCCTGAGGAA 
GAATTGACAA ATATAACTGA TGTGCAGTTT TTACAGTCCA CAAGACCACT GATGTCTTTT 
TGGTGTCGTT TTCGACGTGC TTTTGTTACT GTAACTCACA GATTATTGTT GTTATGCTTA 
GGTGTAGTGA TGGTTTGTGT CGTTCTGCGT TACATGAAAT ATCGATGGAC AAAAGAAGAG 
GAGGAAACAA GGCAGATGTA TGATATGGTG GTAAAGATTA TAGATGTTTT ACGAAGTCAT 
AATGAAGCCT GCCAGGAAAA CAAAGATTTA CAACCTTACA TGCCTATTCC ACATGTACGC 
GATTCCTTAA TACAGCCTCA TGACAGGAAA AAAATGAAGA AAGTCTGGGA TAGAGCTGTT 
GACTTCCTTG CTGCTAATGA GTCTAGAGTT CGCACGGAAA CACGAAGAAT AGGTGGTGCA 
GATTTTCTGG TTTGGCGGTG GATCCAGCCT TCTGCATCCT GTGACAAAAT ATTAGTTATA 
CCTTCTAAAG TATGGCAAGG TCAAGCATTT CATTTAGATA GAAGAAATTC ACCACCAAAT 
AGTTTGACAC CGTGTCTAAA GATTCGGAAT ATGTTTGATC CCGTTATGGA AATAGGGGAT 
CAGTGGCATT TGGCAATTCA AGAAGCAATT TTAGAAAAAT GCAGTGATAA TGATGGCATT 
GTTCACATTG CAGTAGACAA AAATTCACGT GAGGGTTGTG TATATGTTAA ATGTCTGTCT 
CCAGAATATG CTGGAAAGGC TTTTAAAGCA TTGCATGGCT CTTGGTTTGA TGGGAAATTG 
GTTACAGTAA AATATTTACG ACTAGATAGA TACCACCATC GCTTTCCCCA GGCTCTCACT 
TCCAACACTC CATTGAAGCC ATCAAATAAA CATATGAACT CCATGTCTCA TCTTCGTCTT 
CGGACTGGCC TAACCAATTC TCAAGGAAGT TCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055134.2
CDS	27..2762
Translation	MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGNKTRNSNNNNTAAATVAAAGPAAAAAAGMGVRPVSGDLSYLRTPGGLCRISASGPESLLGGPGGASAAPAAGSKVLLGFSSDESDVEASPRDQAGGGGRKDRASLQYRGLKAPPAPLAASEVTNSNSAERRKPHSWWGARRPAGPELQTPPGKDGAVEDEEGEGEDGEERDPETEEPLWASRTVNGSRLVPYSCRENYSDSEEEDDDDVASSRQVLKDDSLSRHRPRRTHSKPLPPLTAKSAGGRLETSVQGGGGLAMNDRAAAAGSLDRSRNLEEAAAAEQGGGCDQVDSSPVPRYRVNAKKLTPLLPPPLTDMDSTLDSSTGSLLKTNNHIGGGAFSVDSPRIYSNSLPPSAAVAASSSLRINHANHTGSNHTYLKNTYNKPKLSEPEEELLQQFKREEVSPTGSFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGELSIENPFGETFGKIQESEKTLMMNTLYKLHDRLAQLAGDHECGSSSQRTLSVQEAAAYLKDLGPEYEGIFNTSLQWILENGKDVGIRCVGFGPEEELTNITDVQFLQSTRPLMSFWCRFRRAFVTVTHRLLLLCLGVVMVCVVLRYMKYRWTKEEEETRQMYDMVVKIIDVLRSHNEACQENKDLQPYMPIPHVRDSLIQPHDRKKMKKVWDRAVDFLAANESRVRTETRRIGGADFLVWRWIQPSASCDKILVIPSKVWQGQAFHLDRRNSPPNSLTPCLKIRNMFDPVMEIGDQWHLAIQEAILEKCSDNDGIVHIAVDKNSREGCVYVKCLSPEYAGKAFKALHGSWFDGKLVTVKYLRLDRYHHRFPQALTSNTPLKPSNKHMNSMSHLRLRTGLTNSQGSS

Target ORF information:

RefSeq Version	NM_014319.4
Organism	Homo sapiens(human)
Definition	Homo sapiens LEM domain containing 3 (LEMD3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014319.4

ORF Insert Sequence:

ATGGCGGCGG CAGCAGCTTC GGCGCCTCAG CAGCTCTCGG ATGAGGAGCT TTTCTCTCAG 
CTCCGCCGTT ACGGCCTGTC TCCCGGACCA GTGACGGAGA GCACCCGCCC GGTCTACCTC 
AAGAAGCTGA AGAAGCTTCG AGAGGAAGAG CAGCAACAGC ACCGGTCAGG GGGCCGCGGC 
AACAAGACGC GGAACAGTAA TAACAATAAC ACGGCAGCCG CCACGGTCGC AGCCGCGGGA 
CCAGCGGCGG CGGCGGCCGC GGGGATGGGG GTCCGGCCGG TCTCGGGCGA CCTCTCCTAC 
TTACGGACTC CTGGGGGCCT GTGCCGAATC TCGGCCTCTG GCCCAGAGAG CCTCCTGGGA 
GGGCCCGGGG GCGCCTCCGC CGCCCCCGCG GCTGGCAGCA AAGTGCTGCT GGGCTTCAGC 
TCGGACGAGT CGGACGTGGA GGCCAGTCCC CGGGACCAGG CCGGCGGCGG CGGGAGGAAA 
GACCGGGCTT CGCTCCAGTA CCGCGGGCTC AAAGCGCCGC CGGCGCCCCT GGCCGCCAGC 
GAGGTGACTA ACAGCAACTC TGCAGAGCGA AGGAAGCCCC ACTCGTGGTG GGGGGCCAGG 
AGGCCGGCGG GCCCCGAGCT GCAGACCCCG CCGGGGAAAG ATGGAGCAGT GGAGGACGAG 
GAAGGGGAGG GAGAGGACGG TGAGGAGAGG GACCCGGAGA CCGAGGAGCC GCTCTGGGCG 
AGCCGGACCG TGAATGGCAG CCGGCTTGTC CCCTACAGCT GCCGGGAAAA CTATTCGGAC 
TCAGAGGAAG AGGACGACGA CGACGTGGCC TCCAGCAGAC AGGTATTAAA GGACGACTCC 
CTTTCCCGGC ATCGGCCCAG ACGAACCCAT AGTAAGCCTC TCCCCCCGCT GACTGCTAAA 
TCGGCCGGCG GCAGGCTGGA GACTTCAGTT CAGGGAGGGG GAGGACTCGC GATGAATGAC 
AGGGCGGCGG CTGCCGGGAG TCTAGACAGG AGCCGAAACC TCGAAGAGGC GGCGGCCGCG 
GAGCAGGGAG GAGGGTGTGA TCAAGTGGAC TCCAGCCCCG TTCCTAGATA CCGTGTTAAC 
GCTAAGAAAC TGACCCCTCT CCTGCCCCCG CCACTTACTG ACATGGACTC AACCTTGGAT 
TCGTCAACAG GCTCCCTTCT GAAAACCAAT AATCATATTG GCGGTGGGGC CTTCAGTGTG 
GACTCCCCCA GGATTTATTC TAACAGTCTC CCTCCCAGTG CGGCGGTGGC CGCCTCTAGT 
TCACTCAGGA TCAATCACGC CAATCATACG GGCTCCAATC ATACCTACCT GAAAAACACA 
TACAACAAAC CGAAGCTTTC CGAACCCGAA GAGGAACTTC TCCAGCAATT TAAACGGGAG 
GAGGTGTCCC CAACAGGGAG TTTCAGTGCC CACTACTTGT CGATGTTTCT CTTAACTGCT 
GCCTGCTTAT TTTTCCTAAT ACTGGGACTG ACTTACCTAG GAATGAGAGG GACAGGAGTA 
TCTGAGGATG GAGAACTCAG CATAGAAAAC CCCTTTGGTG AAACATTTGG AAAAATACAA 
GAAAGTGAAA AAACTCTTAT GATGAACACA TTATATAAGC TTCATGATCG ATTGGCACAG 
CTTGCAGGAG ATCATGAATG TGGCAGTTCT AGTCAAAGAA CGCTTTCTGT TCAAGAGGCA 
GCTGCGTATT TAAAAGATTT AGGTCCTGAA TATGAAGGTA TATTTAACAC TTCATTGCAG 
TGGATCTTAG AAAATGGAAA AGATGTTGGA ATAAGGTGTG TTGGTTTTGG CCCTGAGGAA 
GAATTGACAA ATATAACTGA TGTGCAGTTT TTACAGTCCA CAAGACCACT GATGTCTTTT 
TGGTGTCGTT TTCGACGTGC TTTTGTTACT GTAACTCACA GATTATTGTT GTTATGCTTA 
GGTGTAGTGA TGGTTTGTGT CGTTCTGCGT TACATGAAAT ATCGATGGAC AAAAGAAGAG 
GAGGAAACAA GGCAGATGTA TGATATGGTG GTAAAGATTA TAGATGTTTT ACGAAGTCAT 
AATGAAGCCT GCCAGGAAAA CAAAGATTTA CAACCTTACA TGCCTATTCC ACATGTACGC 
GATTCCTTAA TACAGCCTCA TGACAGGAAA AAAATGAAGA AAGTCTGGGA TAGAGCTGTT 
GACTTCCTTG CTGCTAATGA GTCTAGAGTT CGCACGGAAA CACGAAGAAT AGGTGGTGCA 
GATTTTCTGG TTTGGCGGTG GATCCAGCCT TCTGCATCCT GTGACAAAAT ATTAGTTATA 
CCTTCTAAAG TATGGCAAGG TCAAGCATTT CATTTAGATA GAAGAAATTC ACCACCAAAT 
AGTTTGACAC CGTGTCTAAA GATTCGGAAT ATGTTTGATC CCGTTATGGA AATAGGGGAT 
CAGTGGCATT TGGCAATTCA AGAAGCAATT TTAGAAAAAT GCAGTGATAA TGATGGCATT 
GTTCACATTG CAGTAGACAA AAATTCACGT GAGGGTTGTG TATATGTTAA ATGTCTGTCT 
CCAGAATATG CTGGAAAGGC TTTTAAAGCA TTGCATGGCT CTTGGTTTGA TGGGAAATTG 
GTTACAGTAA AATATTTACG ACTAGATAGA TACCACCATC GCTTTCCCCA GGCTCTCACT 
TCCAACACTC CATTGAAGCC ATCAAATAAA CATATGAACT CCATGTCTCA TCTTCGTCTT 
CGGACTGGCC TAACCAATTC TCAAGGAAGT TCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LEMD3 ( NM_001167614.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001161086.1 Homo sapiens LEM domain containing 3 (LEMD3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04065
Clone ID Related Accession (Same CDS sequence)	NM_001167614.2 , NM_001167614.1
Accession Version	NM_001167614.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2733bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575302400000
Organism	Homo sapiens(human)
Product	inner nuclear membrane protein Man1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK312473.1, AF112299.2 and BX390128.2. On May 31, 2019 this sequence version replaced NM_001167614.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.157539.1, AK312473.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144335, SAMEA2145240 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG CAGCAGCTTC GGCGCCTCAG CAGCTCTCGG ATGAGGAGCT TTTCTCTCAG 
CTCCGCCGTT ACGGCCTGTC TCCCGGACCA GTGACGGAGA GCACCCGCCC GGTCTACCTC 
AAGAAGCTGA AGAAGCTTCG AGAGGAAGAG CAGCAACAGC ACCGGTCAGG GGGCCGCGGC 
AACAAGACGC GGAACAGTAA TAACAATAAC ACGGCAGCCG CCACGGTCGC AGCCGCGGGA 
CCAGCGGCGG CGGCGGCCGC GGGGATGGGG GTCCGGCCGG TCTCGGGCGA CCTCTCCTAC 
TTACGGACTC CTGGGGGCCT GTGCCGAATC TCGGCCTCTG GCCCAGAGAG CCTCCTGGGA 
GGGCCCGGGG GCGCCTCCGC CGCCCCCGCG GCTGGCAGCA AAGTGCTGCT GGGCTTCAGC 
TCGGACGAGT CGGACGTGGA GGCCAGTCCC CGGGACCAGG CCGGCGGCGG CGGGAGGAAA 
GACCGGGCTT CGCTCCAGTA CCGCGGGCTC AAAGCGCCGC CGGCGCCCCT GGCCGCCAGC 
GAGGTGACTA ACAGCAACTC TGCAGAGCGA AGGAAGCCCC ACTCGTGGTG GGGGGCCAGG 
AGGCCGGCGG GCCCCGAGCT GCAGACCCCG CCGGGGAAAG ATGGAGCAGT GGAGGACGAG 
GAAGGGGAGG GAGAGGACGG TGAGGAGAGG GACCCGGAGA CCGAGGAGCC GCTCTGGGCG 
AGCCGGACCG TGAATGGCAG CCGGCTTGTC CCCTACAGCT GCCGGGAAAA CTATTCGGAC 
TCAGAGGAAG AGGACGACGA CGACGTGGCC TCCAGCAGAC AGGTATTAAA GGACGACTCC 
CTTTCCCGGC ATCGGCCCAG ACGAACCCAT AGTAAGCCTC TCCCCCCGCT GACTGCTAAA 
TCGGCCGGCG GCAGGCTGGA GACTTCAGTT CAGGGAGGGG GAGGACTCGC GATGAATGAC 
AGGGCGGCGG CTGCCGGGAG TCTAGACAGG AGCCGAAACC TCGAAGAGGC GGCGGCCGCG 
GAGCAGGGAG GAGGGTGTGA TCAAGTGGAC TCCAGCCCCG TTCCTAGATA CCGTGTTAAC 
GCTAAGAAAC TGACCCCTCT CCTGCCCCCG CCACTTACTG ACATGGACTC AACCTTGGAT 
TCGTCAACAG GCTCCCTTCT GAAAACCAAT AATCATATTG GCGGTGGGGC CTTCAGTGTG 
GACTCCCCCA GGATTTATTC TAACAGTCTC CCTCCCAGTG CGGCGGTGGC CGCCTCTAGT 
TCACTCAGGA TCAATCACGC CAATCATACG GGCTCCAATC ATACCTACCT GAAAAACACA 
TACAACAAAC CGAAGCTTTC CGAACCCGAA GAGGAACTTC TCCAGCAATT TAAACGGGAG 
GAGGTGTCCC CAACAGGGAG TTTCAGTGCC CACTACTTGT CGATGTTTCT CTTAACTGCT 
GCCTGCTTAT TTTTCCTAAT ACTGGGACTG ACTTACCTAG GAATGAGAGG GACAGGAGTA 
TCTGAGGATG GAGAACTCAG CAAAAACCCC TTTGGTGAAA CATTTGGAAA AATACAAGAA 
AGTGAAAAAA CTCTTATGAT GAACACATTA TATAAGCTTC ATGATCGATT GGCACAGCTT 
GCAGGAGATC ATGAATGTGG CAGTTCTAGT CAAAGAACGC TTTCTGTTCA AGAGGCAGCT 
GCGTATTTAA AAGATTTAGG TCCTGAATAT GAAGGTATAT TTAACACTTC ATTGCAGTGG 
ATCTTAGAAA ATGGAAAAGA TGTTGGAATA AGGTGTGTTG GTTTTGGCCC TGAGGAAGAA 
TTGACAAATA TAACTGATGT GCAGTTTTTA CAGTCCACAA GACCACTGAT GTCTTTTTGG 
TGTCGTTTTC GACGTGCTTT TGTTACTGTA ACTCACAGAT TATTGTTGTT ATGCTTAGGT 
GTAGTGATGG TTTGTGTCGT TCTGCGTTAC ATGAAATATC GATGGACAAA AGAAGAGGAG 
GAAACAAGGC AGATGTATGA TATGGTGGTA AAGATTATAG ATGTTTTACG AAGTCATAAT 
GAAGCCTGCC AGGAAAACAA AGATTTACAA CCTTACATGC CTATTCCACA TGTACGCGAT 
TCCTTAATAC AGCCTCATGA CAGGAAAAAA ATGAAGAAAG TCTGGGATAG AGCTGTTGAC 
TTCCTTGCTG CTAATGAGTC TAGAGTTCGC ACGGAAACAC GAAGAATAGG TGGTGCAGAT 
TTTCTGGTTT GGCGGTGGAT CCAGCCTTCT GCATCCTGTG ACAAAATATT AGTTATACCT 
TCTAAAGTAT GGCAAGGTCA AGCATTTCAT TTAGATAGAA GAAATTCACC ACCAAATAGT 
TTGACACCGT GTCTAAAGAT TCGGAATATG TTTGATCCCG TTATGGAAAT AGGGGATCAG 
TGGCATTTGG CAATTCAAGA AGCAATTTTA GAAAAATGCA GTGATAATGA TGGCATTGTT 
CACATTGCAG TAGACAAAAA TTCACGTGAG GGTTGTGTAT ATGTTAAATG TCTGTCTCCA 
GAATATGCTG GAAAGGCTTT TAAAGCATTG CATGGCTCTT GGTTTGATGG GAAATTGGTT 
ACAGTAAAAT ATTTACGACT AGATAGATAC CACCATCGCT TTCCCCAGGC TCTCACTTCC 
AACACTCCAT TGAAGCCATC AAATAAACAT ATGAACTCCA TGTCTCATCT TCGTCTTCGG 
ACTGGCCTAA CCAATTCTCA AGGAAGTTCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001161086.1
CDS	15..2747
Translation	MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGNKTRNSNNNNTAAATVAAAGPAAAAAAGMGVRPVSGDLSYLRTPGGLCRISASGPESLLGGPGGASAAPAAGSKVLLGFSSDESDVEASPRDQAGGGGRKDRASLQYRGLKAPPAPLAASEVTNSNSAERRKPHSWWGARRPAGPELQTPPGKDGAVEDEEGEGEDGEERDPETEEPLWASRTVNGSRLVPYSCRENYSDSEEEDDDDVASSRQVLKDDSLSRHRPRRTHSKPLPPLTAKSAGGRLETSVQGGGGLAMNDRAAAAGSLDRSRNLEEAAAAEQGGGCDQVDSSPVPRYRVNAKKLTPLLPPPLTDMDSTLDSSTGSLLKTNNHIGGGAFSVDSPRIYSNSLPPSAAVAASSSLRINHANHTGSNHTYLKNTYNKPKLSEPEEELLQQFKREEVSPTGSFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGELSKNPFGETFGKIQESEKTLMMNTLYKLHDRLAQLAGDHECGSSSQRTLSVQEAAAYLKDLGPEYEGIFNTSLQWILENGKDVGIRCVGFGPEEELTNITDVQFLQSTRPLMSFWCRFRRAFVTVTHRLLLLCLGVVMVCVVLRYMKYRWTKEEEETRQMYDMVVKIIDVLRSHNEACQENKDLQPYMPIPHVRDSLIQPHDRKKMKKVWDRAVDFLAANESRVRTETRRIGGADFLVWRWIQPSASCDKILVIPSKVWQGQAFHLDRRNSPPNSLTPCLKIRNMFDPVMEIGDQWHLAIQEAILEKCSDNDGIVHIAVDKNSREGCVYVKCLSPEYAGKAFKALHGSWFDGKLVTVKYLRLDRYHHRFPQALTSNTPLKPSNKHMNSMSHLRLRTGLTNSQGSS

Target ORF information:

RefSeq Version	NM_001167614.2
Organism	Homo sapiens(human)
Definition	Homo sapiens LEM domain containing 3 (LEMD3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001167614.2

ORF Insert Sequence:

ATGGCGGCGG CAGCAGCTTC GGCGCCTCAG CAGCTCTCGG ATGAGGAGCT TTTCTCTCAG 
CTCCGCCGTT ACGGCCTGTC TCCCGGACCA GTGACGGAGA GCACCCGCCC GGTCTACCTC 
AAGAAGCTGA AGAAGCTTCG AGAGGAAGAG CAGCAACAGC ACCGGTCAGG GGGCCGCGGC 
AACAAGACGC GGAACAGTAA TAACAATAAC ACGGCAGCCG CCACGGTCGC AGCCGCGGGA 
CCAGCGGCGG CGGCGGCCGC GGGGATGGGG GTCCGGCCGG TCTCGGGCGA CCTCTCCTAC 
TTACGGACTC CTGGGGGCCT GTGCCGAATC TCGGCCTCTG GCCCAGAGAG CCTCCTGGGA 
GGGCCCGGGG GCGCCTCCGC CGCCCCCGCG GCTGGCAGCA AAGTGCTGCT GGGCTTCAGC 
TCGGACGAGT CGGACGTGGA GGCCAGTCCC CGGGACCAGG CCGGCGGCGG CGGGAGGAAA 
GACCGGGCTT CGCTCCAGTA CCGCGGGCTC AAAGCGCCGC CGGCGCCCCT GGCCGCCAGC 
GAGGTGACTA ACAGCAACTC TGCAGAGCGA AGGAAGCCCC ACTCGTGGTG GGGGGCCAGG 
AGGCCGGCGG GCCCCGAGCT GCAGACCCCG CCGGGGAAAG ATGGAGCAGT GGAGGACGAG 
GAAGGGGAGG GAGAGGACGG TGAGGAGAGG GACCCGGAGA CCGAGGAGCC GCTCTGGGCG 
AGCCGGACCG TGAATGGCAG CCGGCTTGTC CCCTACAGCT GCCGGGAAAA CTATTCGGAC 
TCAGAGGAAG AGGACGACGA CGACGTGGCC TCCAGCAGAC AGGTATTAAA GGACGACTCC 
CTTTCCCGGC ATCGGCCCAG ACGAACCCAT AGTAAGCCTC TCCCCCCGCT GACTGCTAAA 
TCGGCCGGCG GCAGGCTGGA GACTTCAGTT CAGGGAGGGG GAGGACTCGC GATGAATGAC 
AGGGCGGCGG CTGCCGGGAG TCTAGACAGG AGCCGAAACC TCGAAGAGGC GGCGGCCGCG 
GAGCAGGGAG GAGGGTGTGA TCAAGTGGAC TCCAGCCCCG TTCCTAGATA CCGTGTTAAC 
GCTAAGAAAC TGACCCCTCT CCTGCCCCCG CCACTTACTG ACATGGACTC AACCTTGGAT 
TCGTCAACAG GCTCCCTTCT GAAAACCAAT AATCATATTG GCGGTGGGGC CTTCAGTGTG 
GACTCCCCCA GGATTTATTC TAACAGTCTC CCTCCCAGTG CGGCGGTGGC CGCCTCTAGT 
TCACTCAGGA TCAATCACGC CAATCATACG GGCTCCAATC ATACCTACCT GAAAAACACA 
TACAACAAAC CGAAGCTTTC CGAACCCGAA GAGGAACTTC TCCAGCAATT TAAACGGGAG 
GAGGTGTCCC CAACAGGGAG TTTCAGTGCC CACTACTTGT CGATGTTTCT CTTAACTGCT 
GCCTGCTTAT TTTTCCTAAT ACTGGGACTG ACTTACCTAG GAATGAGAGG GACAGGAGTA 
TCTGAGGATG GAGAACTCAG CAAAAACCCC TTTGGTGAAA CATTTGGAAA AATACAAGAA 
AGTGAAAAAA CTCTTATGAT GAACACATTA TATAAGCTTC ATGATCGATT GGCACAGCTT 
GCAGGAGATC ATGAATGTGG CAGTTCTAGT CAAAGAACGC TTTCTGTTCA AGAGGCAGCT 
GCGTATTTAA AAGATTTAGG TCCTGAATAT GAAGGTATAT TTAACACTTC ATTGCAGTGG 
ATCTTAGAAA ATGGAAAAGA TGTTGGAATA AGGTGTGTTG GTTTTGGCCC TGAGGAAGAA 
TTGACAAATA TAACTGATGT GCAGTTTTTA CAGTCCACAA GACCACTGAT GTCTTTTTGG 
TGTCGTTTTC GACGTGCTTT TGTTACTGTA ACTCACAGAT TATTGTTGTT ATGCTTAGGT 
GTAGTGATGG TTTGTGTCGT TCTGCGTTAC ATGAAATATC GATGGACAAA AGAAGAGGAG 
GAAACAAGGC AGATGTATGA TATGGTGGTA AAGATTATAG ATGTTTTACG AAGTCATAAT 
GAAGCCTGCC AGGAAAACAA AGATTTACAA CCTTACATGC CTATTCCACA TGTACGCGAT 
TCCTTAATAC AGCCTCATGA CAGGAAAAAA ATGAAGAAAG TCTGGGATAG AGCTGTTGAC 
TTCCTTGCTG CTAATGAGTC TAGAGTTCGC ACGGAAACAC GAAGAATAGG TGGTGCAGAT 
TTTCTGGTTT GGCGGTGGAT CCAGCCTTCT GCATCCTGTG ACAAAATATT AGTTATACCT 
TCTAAAGTAT GGCAAGGTCA AGCATTTCAT TTAGATAGAA GAAATTCACC ACCAAATAGT 
TTGACACCGT GTCTAAAGAT TCGGAATATG TTTGATCCCG TTATGGAAAT AGGGGATCAG 
TGGCATTTGG CAATTCAAGA AGCAATTTTA GAAAAATGCA GTGATAATGA TGGCATTGTT 
CACATTGCAG TAGACAAAAA TTCACGTGAG GGTTGTGTAT ATGTTAAATG TCTGTCTCCA 
GAATATGCTG GAAAGGCTTT TAAAGCATTG CATGGCTCTT GGTTTGATGG GAAATTGGTT 
ACAGTAAAAT ATTTACGACT AGATAGATAC CACCATCGCT TTCCCCAGGC TCTCACTTCC 
AACACTCCAT TGAAGCCATC AAATAAACAT ATGAACTCCA TGTCTCATCT TCGTCTTCGG 
ACTGGCCTAA CCAATTCTCA AGGAAGTTCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LEMD3 ( NM_001167614.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001161086.1 Homo sapiens LEM domain containing 3 (LEMD3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04065
Clone ID Related Accession (Same CDS sequence)	NM_001167614.2 , NM_001167614.1
Accession Version	NM_001167614.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2733bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550678400000
Organism	Homo sapiens(human)
Product	inner nuclear membrane protein Man1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK312473.1, AF112299.2 and BX390128.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK312473.1, SRR1660807.157539.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144335, SAMEA2145240 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG CAGCAGCTTC GGCGCCTCAG CAGCTCTCGG ATGAGGAGCT TTTCTCTCAG 
CTCCGCCGTT ACGGCCTGTC TCCCGGACCA GTGACGGAGA GCACCCGCCC GGTCTACCTC 
AAGAAGCTGA AGAAGCTTCG AGAGGAAGAG CAGCAACAGC ACCGGTCAGG GGGCCGCGGC 
AACAAGACGC GGAACAGTAA TAACAATAAC ACGGCAGCCG CCACGGTCGC AGCCGCGGGA 
CCAGCGGCGG CGGCGGCCGC GGGGATGGGG GTCCGGCCGG TCTCGGGCGA CCTCTCCTAC 
TTACGGACTC CTGGGGGCCT GTGCCGAATC TCGGCCTCTG GCCCAGAGAG CCTCCTGGGA 
GGGCCCGGGG GCGCCTCCGC CGCCCCCGCG GCTGGCAGCA AAGTGCTGCT GGGCTTCAGC 
TCGGACGAGT CGGACGTGGA GGCCAGTCCC CGGGACCAGG CCGGCGGCGG CGGGAGGAAA 
GACCGGGCTT CGCTCCAGTA CCGCGGGCTC AAAGCGCCGC CGGCGCCCCT GGCCGCCAGC 
GAGGTGACTA ACAGCAACTC TGCAGAGCGA AGGAAGCCCC ACTCGTGGTG GGGGGCCAGG 
AGGCCGGCGG GCCCCGAGCT GCAGACCCCG CCGGGGAAAG ATGGAGCAGT GGAGGACGAG 
GAAGGGGAGG GAGAGGACGG TGAGGAGAGG GACCCGGAGA CCGAGGAGCC GCTCTGGGCG 
AGCCGGACCG TGAATGGCAG CCGGCTTGTC CCCTACAGCT GCCGGGAAAA CTATTCGGAC 
TCAGAGGAAG AGGACGACGA CGACGTGGCC TCCAGCAGAC AGGTATTAAA GGACGACTCC 
CTTTCCCGGC ATCGGCCCAG ACGAACCCAT AGTAAGCCTC TCCCCCCGCT GACTGCTAAA 
TCGGCCGGCG GCAGGCTGGA GACTTCAGTT CAGGGAGGGG GAGGACTCGC GATGAATGAC 
AGGGCGGCGG CTGCCGGGAG TCTAGACAGG AGCCGAAACC TCGAAGAGGC GGCGGCCGCG 
GAGCAGGGAG GAGGGTGTGA TCAAGTGGAC TCCAGCCCCG TTCCTAGATA CCGTGTTAAC 
GCTAAGAAAC TGACCCCTCT CCTGCCCCCG CCACTTACTG ACATGGACTC AACCTTGGAT 
TCGTCAACAG GCTCCCTTCT GAAAACCAAT AATCATATTG GCGGTGGGGC CTTCAGTGTG 
GACTCCCCCA GGATTTATTC TAACAGTCTC CCTCCCAGTG CGGCGGTGGC CGCCTCTAGT 
TCACTCAGGA TCAATCACGC CAATCATACG GGCTCCAATC ATACCTACCT GAAAAACACA 
TACAACAAAC CGAAGCTTTC CGAACCCGAA GAGGAACTTC TCCAGCAATT TAAACGGGAG 
GAGGTGTCCC CAACAGGGAG TTTCAGTGCC CACTACTTGT CGATGTTTCT CTTAACTGCT 
GCCTGCTTAT TTTTCCTAAT ACTGGGACTG ACTTACCTAG GAATGAGAGG GACAGGAGTA 
TCTGAGGATG GAGAACTCAG CAAAAACCCC TTTGGTGAAA CATTTGGAAA AATACAAGAA 
AGTGAAAAAA CTCTTATGAT GAACACATTA TATAAGCTTC ATGATCGATT GGCACAGCTT 
GCAGGAGATC ATGAATGTGG CAGTTCTAGT CAAAGAACGC TTTCTGTTCA AGAGGCAGCT 
GCGTATTTAA AAGATTTAGG TCCTGAATAT GAAGGTATAT TTAACACTTC ATTGCAGTGG 
ATCTTAGAAA ATGGAAAAGA TGTTGGAATA AGGTGTGTTG GTTTTGGCCC TGAGGAAGAA 
TTGACAAATA TAACTGATGT GCAGTTTTTA CAGTCCACAA GACCACTGAT GTCTTTTTGG 
TGTCGTTTTC GACGTGCTTT TGTTACTGTA ACTCACAGAT TATTGTTGTT ATGCTTAGGT 
GTAGTGATGG TTTGTGTCGT TCTGCGTTAC ATGAAATATC GATGGACAAA AGAAGAGGAG 
GAAACAAGGC AGATGTATGA TATGGTGGTA AAGATTATAG ATGTTTTACG AAGTCATAAT 
GAAGCCTGCC AGGAAAACAA AGATTTACAA CCTTACATGC CTATTCCACA TGTACGCGAT 
TCCTTAATAC AGCCTCATGA CAGGAAAAAA ATGAAGAAAG TCTGGGATAG AGCTGTTGAC 
TTCCTTGCTG CTAATGAGTC TAGAGTTCGC ACGGAAACAC GAAGAATAGG TGGTGCAGAT 
TTTCTGGTTT GGCGGTGGAT CCAGCCTTCT GCATCCTGTG ACAAAATATT AGTTATACCT 
TCTAAAGTAT GGCAAGGTCA AGCATTTCAT TTAGATAGAA GAAATTCACC ACCAAATAGT 
TTGACACCGT GTCTAAAGAT TCGGAATATG TTTGATCCCG TTATGGAAAT AGGGGATCAG 
TGGCATTTGG CAATTCAAGA AGCAATTTTA GAAAAATGCA GTGATAATGA TGGCATTGTT 
CACATTGCAG TAGACAAAAA TTCACGTGAG GGTTGTGTAT ATGTTAAATG TCTGTCTCCA 
GAATATGCTG GAAAGGCTTT TAAAGCATTG CATGGCTCTT GGTTTGATGG GAAATTGGTT 
ACAGTAAAAT ATTTACGACT AGATAGATAC CACCATCGCT TTCCCCAGGC TCTCACTTCC 
AACACTCCAT TGAAGCCATC AAATAAACAT ATGAACTCCA TGTCTCATCT TCGTCTTCGG 
ACTGGCCTAA CCAATTCTCA AGGAAGTTCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001161086.1
CDS	27..2759
Translation	MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGNKTRNSNNNNTAAATVAAAGPAAAAAAGMGVRPVSGDLSYLRTPGGLCRISASGPESLLGGPGGASAAPAAGSKVLLGFSSDESDVEASPRDQAGGGGRKDRASLQYRGLKAPPAPLAASEVTNSNSAERRKPHSWWGARRPAGPELQTPPGKDGAVEDEEGEGEDGEERDPETEEPLWASRTVNGSRLVPYSCRENYSDSEEEDDDDVASSRQVLKDDSLSRHRPRRTHSKPLPPLTAKSAGGRLETSVQGGGGLAMNDRAAAAGSLDRSRNLEEAAAAEQGGGCDQVDSSPVPRYRVNAKKLTPLLPPPLTDMDSTLDSSTGSLLKTNNHIGGGAFSVDSPRIYSNSLPPSAAVAASSSLRINHANHTGSNHTYLKNTYNKPKLSEPEEELLQQFKREEVSPTGSFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGELSKNPFGETFGKIQESEKTLMMNTLYKLHDRLAQLAGDHECGSSSQRTLSVQEAAAYLKDLGPEYEGIFNTSLQWILENGKDVGIRCVGFGPEEELTNITDVQFLQSTRPLMSFWCRFRRAFVTVTHRLLLLCLGVVMVCVVLRYMKYRWTKEEEETRQMYDMVVKIIDVLRSHNEACQENKDLQPYMPIPHVRDSLIQPHDRKKMKKVWDRAVDFLAANESRVRTETRRIGGADFLVWRWIQPSASCDKILVIPSKVWQGQAFHLDRRNSPPNSLTPCLKIRNMFDPVMEIGDQWHLAIQEAILEKCSDNDGIVHIAVDKNSREGCVYVKCLSPEYAGKAFKALHGSWFDGKLVTVKYLRLDRYHHRFPQALTSNTPLKPSNKHMNSMSHLRLRTGLTNSQGSS

Target ORF information:

RefSeq Version	NM_001167614.1
Organism	Homo sapiens(human)
Definition	Homo sapiens LEM domain containing 3 (LEMD3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001167614.1

ORF Insert Sequence:

ATGGCGGCGG CAGCAGCTTC GGCGCCTCAG CAGCTCTCGG ATGAGGAGCT TTTCTCTCAG 
CTCCGCCGTT ACGGCCTGTC TCCCGGACCA GTGACGGAGA GCACCCGCCC GGTCTACCTC 
AAGAAGCTGA AGAAGCTTCG AGAGGAAGAG CAGCAACAGC ACCGGTCAGG GGGCCGCGGC 
AACAAGACGC GGAACAGTAA TAACAATAAC ACGGCAGCCG CCACGGTCGC AGCCGCGGGA 
CCAGCGGCGG CGGCGGCCGC GGGGATGGGG GTCCGGCCGG TCTCGGGCGA CCTCTCCTAC 
TTACGGACTC CTGGGGGCCT GTGCCGAATC TCGGCCTCTG GCCCAGAGAG CCTCCTGGGA 
GGGCCCGGGG GCGCCTCCGC CGCCCCCGCG GCTGGCAGCA AAGTGCTGCT GGGCTTCAGC 
TCGGACGAGT CGGACGTGGA GGCCAGTCCC CGGGACCAGG CCGGCGGCGG CGGGAGGAAA 
GACCGGGCTT CGCTCCAGTA CCGCGGGCTC AAAGCGCCGC CGGCGCCCCT GGCCGCCAGC 
GAGGTGACTA ACAGCAACTC TGCAGAGCGA AGGAAGCCCC ACTCGTGGTG GGGGGCCAGG 
AGGCCGGCGG GCCCCGAGCT GCAGACCCCG CCGGGGAAAG ATGGAGCAGT GGAGGACGAG 
GAAGGGGAGG GAGAGGACGG TGAGGAGAGG GACCCGGAGA CCGAGGAGCC GCTCTGGGCG 
AGCCGGACCG TGAATGGCAG CCGGCTTGTC CCCTACAGCT GCCGGGAAAA CTATTCGGAC 
TCAGAGGAAG AGGACGACGA CGACGTGGCC TCCAGCAGAC AGGTATTAAA GGACGACTCC 
CTTTCCCGGC ATCGGCCCAG ACGAACCCAT AGTAAGCCTC TCCCCCCGCT GACTGCTAAA 
TCGGCCGGCG GCAGGCTGGA GACTTCAGTT CAGGGAGGGG GAGGACTCGC GATGAATGAC 
AGGGCGGCGG CTGCCGGGAG TCTAGACAGG AGCCGAAACC TCGAAGAGGC GGCGGCCGCG 
GAGCAGGGAG GAGGGTGTGA TCAAGTGGAC TCCAGCCCCG TTCCTAGATA CCGTGTTAAC 
GCTAAGAAAC TGACCCCTCT CCTGCCCCCG CCACTTACTG ACATGGACTC AACCTTGGAT 
TCGTCAACAG GCTCCCTTCT GAAAACCAAT AATCATATTG GCGGTGGGGC CTTCAGTGTG 
GACTCCCCCA GGATTTATTC TAACAGTCTC CCTCCCAGTG CGGCGGTGGC CGCCTCTAGT 
TCACTCAGGA TCAATCACGC CAATCATACG GGCTCCAATC ATACCTACCT GAAAAACACA 
TACAACAAAC CGAAGCTTTC CGAACCCGAA GAGGAACTTC TCCAGCAATT TAAACGGGAG 
GAGGTGTCCC CAACAGGGAG TTTCAGTGCC CACTACTTGT CGATGTTTCT CTTAACTGCT 
GCCTGCTTAT TTTTCCTAAT ACTGGGACTG ACTTACCTAG GAATGAGAGG GACAGGAGTA 
TCTGAGGATG GAGAACTCAG CAAAAACCCC TTTGGTGAAA CATTTGGAAA AATACAAGAA 
AGTGAAAAAA CTCTTATGAT GAACACATTA TATAAGCTTC ATGATCGATT GGCACAGCTT 
GCAGGAGATC ATGAATGTGG CAGTTCTAGT CAAAGAACGC TTTCTGTTCA AGAGGCAGCT 
GCGTATTTAA AAGATTTAGG TCCTGAATAT GAAGGTATAT TTAACACTTC ATTGCAGTGG 
ATCTTAGAAA ATGGAAAAGA TGTTGGAATA AGGTGTGTTG GTTTTGGCCC TGAGGAAGAA 
TTGACAAATA TAACTGATGT GCAGTTTTTA CAGTCCACAA GACCACTGAT GTCTTTTTGG 
TGTCGTTTTC GACGTGCTTT TGTTACTGTA ACTCACAGAT TATTGTTGTT ATGCTTAGGT 
GTAGTGATGG TTTGTGTCGT TCTGCGTTAC ATGAAATATC GATGGACAAA AGAAGAGGAG 
GAAACAAGGC AGATGTATGA TATGGTGGTA AAGATTATAG ATGTTTTACG AAGTCATAAT 
GAAGCCTGCC AGGAAAACAA AGATTTACAA CCTTACATGC CTATTCCACA TGTACGCGAT 
TCCTTAATAC AGCCTCATGA CAGGAAAAAA ATGAAGAAAG TCTGGGATAG AGCTGTTGAC 
TTCCTTGCTG CTAATGAGTC TAGAGTTCGC ACGGAAACAC GAAGAATAGG TGGTGCAGAT 
TTTCTGGTTT GGCGGTGGAT CCAGCCTTCT GCATCCTGTG ACAAAATATT AGTTATACCT 
TCTAAAGTAT GGCAAGGTCA AGCATTTCAT TTAGATAGAA GAAATTCACC ACCAAATAGT 
TTGACACCGT GTCTAAAGAT TCGGAATATG TTTGATCCCG TTATGGAAAT AGGGGATCAG 
TGGCATTTGG CAATTCAAGA AGCAATTTTA GAAAAATGCA GTGATAATGA TGGCATTGTT 
CACATTGCAG TAGACAAAAA TTCACGTGAG GGTTGTGTAT ATGTTAAATG TCTGTCTCCA 
GAATATGCTG GAAAGGCTTT TAAAGCATTG CATGGCTCTT GGTTTGATGG GAAATTGGTT 
ACAGTAAAAT ATTTACGACT AGATAGATAC CACCATCGCT TTCCCCAGGC TCTCACTTCC 
AACACTCCAT TGAAGCCATC AAATAAACAT ATGAACTCCA TGTCTCATCT TCGTCTTCGG 
ACTGGCCTAA CCAATTCTCA AGGAAGTTCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LEMD3 ( NM_014319.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_055134.2 Homo sapiens LEM domain containing 3 (LEMD3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19032
Clone ID Related Accession (Same CDS sequence)	NM_014319.5 , NM_014319.4
Accession Version	NM_014319.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2736bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575302400000
Organism	Homo sapiens(human)
Product	inner nuclear membrane protein Man1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK312473.1, AF112299.2 and BX390128.2. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_014319.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.145863.1, SRR1660807.46629.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000308330.3/ ENSP00000308369.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCGG CAGCAGCTTC GGCGCCTCAG CAGCTCTCGG ATGAGGAGCT TTTCTCTCAG 
CTCCGCCGTT ACGGCCTGTC TCCCGGACCA GTGACGGAGA GCACCCGCCC GGTCTACCTC 
AAGAAGCTGA AGAAGCTTCG AGAGGAAGAG CAGCAACAGC ACCGGTCAGG GGGCCGCGGC 
AACAAGACGC GGAACAGTAA TAACAATAAC ACGGCAGCCG CCACGGTCGC AGCCGCGGGA 
CCAGCGGCGG CGGCGGCCGC GGGGATGGGG GTCCGGCCGG TCTCGGGCGA CCTCTCCTAC 
TTACGGACTC CTGGGGGCCT GTGCCGAATC TCGGCCTCTG GCCCAGAGAG CCTCCTGGGA 
GGGCCCGGGG GCGCCTCCGC CGCCCCCGCG GCTGGCAGCA AAGTGCTGCT GGGCTTCAGC 
TCGGACGAGT CGGACGTGGA GGCCAGTCCC CGGGACCAGG CCGGCGGCGG CGGGAGGAAA 
GACCGGGCTT CGCTCCAGTA CCGCGGGCTC AAAGCGCCGC CGGCGCCCCT GGCCGCCAGC 
GAGGTGACTA ACAGCAACTC TGCAGAGCGA AGGAAGCCCC ACTCGTGGTG GGGGGCCAGG 
AGGCCGGCGG GCCCCGAGCT GCAGACCCCG CCGGGGAAAG ATGGAGCAGT GGAGGACGAG 
GAAGGGGAGG GAGAGGACGG TGAGGAGAGG GACCCGGAGA CCGAGGAGCC GCTCTGGGCG 
AGCCGGACCG TGAATGGCAG CCGGCTTGTC CCCTACAGCT GCCGGGAAAA CTATTCGGAC 
TCAGAGGAAG AGGACGACGA CGACGTGGCC TCCAGCAGAC AGGTATTAAA GGACGACTCC 
CTTTCCCGGC ATCGGCCCAG ACGAACCCAT AGTAAGCCTC TCCCCCCGCT GACTGCTAAA 
TCGGCCGGCG GCAGGCTGGA GACTTCAGTT CAGGGAGGGG GAGGACTCGC GATGAATGAC 
AGGGCGGCGG CTGCCGGGAG TCTAGACAGG AGCCGAAACC TCGAAGAGGC GGCGGCCGCG 
GAGCAGGGAG GAGGGTGTGA TCAAGTGGAC TCCAGCCCCG TTCCTAGATA CCGTGTTAAC 
GCTAAGAAAC TGACCCCTCT CCTGCCCCCG CCACTTACTG ACATGGACTC AACCTTGGAT 
TCGTCAACAG GCTCCCTTCT GAAAACCAAT AATCATATTG GCGGTGGGGC CTTCAGTGTG 
GACTCCCCCA GGATTTATTC TAACAGTCTC CCTCCCAGTG CGGCGGTGGC CGCCTCTAGT 
TCACTCAGGA TCAATCACGC CAATCATACG GGCTCCAATC ATACCTACCT GAAAAACACA 
TACAACAAAC CGAAGCTTTC CGAACCCGAA GAGGAACTTC TCCAGCAATT TAAACGGGAG 
GAGGTGTCCC CAACAGGGAG TTTCAGTGCC CACTACTTGT CGATGTTTCT CTTAACTGCT 
GCCTGCTTAT TTTTCCTAAT ACTGGGACTG ACTTACCTAG GAATGAGAGG GACAGGAGTA 
TCTGAGGATG GAGAACTCAG CATAGAAAAC CCCTTTGGTG AAACATTTGG AAAAATACAA 
GAAAGTGAAA AAACTCTTAT GATGAACACA TTATATAAGC TTCATGATCG ATTGGCACAG 
CTTGCAGGAG ATCATGAATG TGGCAGTTCT AGTCAAAGAA CGCTTTCTGT TCAAGAGGCA 
GCTGCGTATT TAAAAGATTT AGGTCCTGAA TATGAAGGTA TATTTAACAC TTCATTGCAG 
TGGATCTTAG AAAATGGAAA AGATGTTGGA ATAAGGTGTG TTGGTTTTGG CCCTGAGGAA 
GAATTGACAA ATATAACTGA TGTGCAGTTT TTACAGTCCA CAAGACCACT GATGTCTTTT 
TGGTGTCGTT TTCGACGTGC TTTTGTTACT GTAACTCACA GATTATTGTT GTTATGCTTA 
GGTGTAGTGA TGGTTTGTGT CGTTCTGCGT TACATGAAAT ATCGATGGAC AAAAGAAGAG 
GAGGAAACAA GGCAGATGTA TGATATGGTG GTAAAGATTA TAGATGTTTT ACGAAGTCAT 
AATGAAGCCT GCCAGGAAAA CAAAGATTTA CAACCTTACA TGCCTATTCC ACATGTACGC 
GATTCCTTAA TACAGCCTCA TGACAGGAAA AAAATGAAGA AAGTCTGGGA TAGAGCTGTT 
GACTTCCTTG CTGCTAATGA GTCTAGAGTT CGCACGGAAA CACGAAGAAT AGGTGGTGCA 
GATTTTCTGG TTTGGCGGTG GATCCAGCCT TCTGCATCCT GTGACAAAAT ATTAGTTATA 
CCTTCTAAAG TATGGCAAGG TCAAGCATTT CATTTAGATA GAAGAAATTC ACCACCAAAT 
AGTTTGACAC CGTGTCTAAA GATTCGGAAT ATGTTTGATC CCGTTATGGA AATAGGGGAT 
CAGTGGCATT TGGCAATTCA AGAAGCAATT TTAGAAAAAT GCAGTGATAA TGATGGCATT 
GTTCACATTG CAGTAGACAA AAATTCACGT GAGGGTTGTG TATATGTTAA ATGTCTGTCT 
CCAGAATATG CTGGAAAGGC TTTTAAAGCA TTGCATGGCT CTTGGTTTGA TGGGAAATTG 
GTTACAGTAA AATATTTACG ACTAGATAGA TACCACCATC GCTTTCCCCA GGCTCTCACT 
TCCAACACTC CATTGAAGCC ATCAAATAAA CATATGAACT CCATGTCTCA TCTTCGTCTT 
CGGACTGGCC TAACCAATTC TCAAGGAAGT TCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055134.2
CDS	15..2750
Translation	MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGNKTRNSNNNNTAAATVAAAGPAAAAAAGMGVRPVSGDLSYLRTPGGLCRISASGPESLLGGPGGASAAPAAGSKVLLGFSSDESDVEASPRDQAGGGGRKDRASLQYRGLKAPPAPLAASEVTNSNSAERRKPHSWWGARRPAGPELQTPPGKDGAVEDEEGEGEDGEERDPETEEPLWASRTVNGSRLVPYSCRENYSDSEEEDDDDVASSRQVLKDDSLSRHRPRRTHSKPLPPLTAKSAGGRLETSVQGGGGLAMNDRAAAAGSLDRSRNLEEAAAAEQGGGCDQVDSSPVPRYRVNAKKLTPLLPPPLTDMDSTLDSSTGSLLKTNNHIGGGAFSVDSPRIYSNSLPPSAAVAASSSLRINHANHTGSNHTYLKNTYNKPKLSEPEEELLQQFKREEVSPTGSFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGELSIENPFGETFGKIQESEKTLMMNTLYKLHDRLAQLAGDHECGSSSQRTLSVQEAAAYLKDLGPEYEGIFNTSLQWILENGKDVGIRCVGFGPEEELTNITDVQFLQSTRPLMSFWCRFRRAFVTVTHRLLLLCLGVVMVCVVLRYMKYRWTKEEEETRQMYDMVVKIIDVLRSHNEACQENKDLQPYMPIPHVRDSLIQPHDRKKMKKVWDRAVDFLAANESRVRTETRRIGGADFLVWRWIQPSASCDKILVIPSKVWQGQAFHLDRRNSPPNSLTPCLKIRNMFDPVMEIGDQWHLAIQEAILEKCSDNDGIVHIAVDKNSREGCVYVKCLSPEYAGKAFKALHGSWFDGKLVTVKYLRLDRYHHRFPQALTSNTPLKPSNKHMNSMSHLRLRTGLTNSQGSS

Target ORF information:

RefSeq Version	NM_014319.5
Organism	Homo sapiens(human)
Definition	Homo sapiens LEM domain containing 3 (LEMD3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014319.5

ORF Insert Sequence:

ATGGCGGCGG CAGCAGCTTC GGCGCCTCAG CAGCTCTCGG ATGAGGAGCT TTTCTCTCAG 
CTCCGCCGTT ACGGCCTGTC TCCCGGACCA GTGACGGAGA GCACCCGCCC GGTCTACCTC 
AAGAAGCTGA AGAAGCTTCG AGAGGAAGAG CAGCAACAGC ACCGGTCAGG GGGCCGCGGC 
AACAAGACGC GGAACAGTAA TAACAATAAC ACGGCAGCCG CCACGGTCGC AGCCGCGGGA 
CCAGCGGCGG CGGCGGCCGC GGGGATGGGG GTCCGGCCGG TCTCGGGCGA CCTCTCCTAC 
TTACGGACTC CTGGGGGCCT GTGCCGAATC TCGGCCTCTG GCCCAGAGAG CCTCCTGGGA 
GGGCCCGGGG GCGCCTCCGC CGCCCCCGCG GCTGGCAGCA AAGTGCTGCT GGGCTTCAGC 
TCGGACGAGT CGGACGTGGA GGCCAGTCCC CGGGACCAGG CCGGCGGCGG CGGGAGGAAA 
GACCGGGCTT CGCTCCAGTA CCGCGGGCTC AAAGCGCCGC CGGCGCCCCT GGCCGCCAGC 
GAGGTGACTA ACAGCAACTC TGCAGAGCGA AGGAAGCCCC ACTCGTGGTG GGGGGCCAGG 
AGGCCGGCGG GCCCCGAGCT GCAGACCCCG CCGGGGAAAG ATGGAGCAGT GGAGGACGAG 
GAAGGGGAGG GAGAGGACGG TGAGGAGAGG GACCCGGAGA CCGAGGAGCC GCTCTGGGCG 
AGCCGGACCG TGAATGGCAG CCGGCTTGTC CCCTACAGCT GCCGGGAAAA CTATTCGGAC 
TCAGAGGAAG AGGACGACGA CGACGTGGCC TCCAGCAGAC AGGTATTAAA GGACGACTCC 
CTTTCCCGGC ATCGGCCCAG ACGAACCCAT AGTAAGCCTC TCCCCCCGCT GACTGCTAAA 
TCGGCCGGCG GCAGGCTGGA GACTTCAGTT CAGGGAGGGG GAGGACTCGC GATGAATGAC 
AGGGCGGCGG CTGCCGGGAG TCTAGACAGG AGCCGAAACC TCGAAGAGGC GGCGGCCGCG 
GAGCAGGGAG GAGGGTGTGA TCAAGTGGAC TCCAGCCCCG TTCCTAGATA CCGTGTTAAC 
GCTAAGAAAC TGACCCCTCT CCTGCCCCCG CCACTTACTG ACATGGACTC AACCTTGGAT 
TCGTCAACAG GCTCCCTTCT GAAAACCAAT AATCATATTG GCGGTGGGGC CTTCAGTGTG 
GACTCCCCCA GGATTTATTC TAACAGTCTC CCTCCCAGTG CGGCGGTGGC CGCCTCTAGT 
TCACTCAGGA TCAATCACGC CAATCATACG GGCTCCAATC ATACCTACCT GAAAAACACA 
TACAACAAAC CGAAGCTTTC CGAACCCGAA GAGGAACTTC TCCAGCAATT TAAACGGGAG 
GAGGTGTCCC CAACAGGGAG TTTCAGTGCC CACTACTTGT CGATGTTTCT CTTAACTGCT 
GCCTGCTTAT TTTTCCTAAT ACTGGGACTG ACTTACCTAG GAATGAGAGG GACAGGAGTA 
TCTGAGGATG GAGAACTCAG CATAGAAAAC CCCTTTGGTG AAACATTTGG AAAAATACAA 
GAAAGTGAAA AAACTCTTAT GATGAACACA TTATATAAGC TTCATGATCG ATTGGCACAG 
CTTGCAGGAG ATCATGAATG TGGCAGTTCT AGTCAAAGAA CGCTTTCTGT TCAAGAGGCA 
GCTGCGTATT TAAAAGATTT AGGTCCTGAA TATGAAGGTA TATTTAACAC TTCATTGCAG 
TGGATCTTAG AAAATGGAAA AGATGTTGGA ATAAGGTGTG TTGGTTTTGG CCCTGAGGAA 
GAATTGACAA ATATAACTGA TGTGCAGTTT TTACAGTCCA CAAGACCACT GATGTCTTTT 
TGGTGTCGTT TTCGACGTGC TTTTGTTACT GTAACTCACA GATTATTGTT GTTATGCTTA 
GGTGTAGTGA TGGTTTGTGT CGTTCTGCGT TACATGAAAT ATCGATGGAC AAAAGAAGAG 
GAGGAAACAA GGCAGATGTA TGATATGGTG GTAAAGATTA TAGATGTTTT ACGAAGTCAT 
AATGAAGCCT GCCAGGAAAA CAAAGATTTA CAACCTTACA TGCCTATTCC ACATGTACGC 
GATTCCTTAA TACAGCCTCA TGACAGGAAA AAAATGAAGA AAGTCTGGGA TAGAGCTGTT 
GACTTCCTTG CTGCTAATGA GTCTAGAGTT CGCACGGAAA CACGAAGAAT AGGTGGTGCA 
GATTTTCTGG TTTGGCGGTG GATCCAGCCT TCTGCATCCT GTGACAAAAT ATTAGTTATA 
CCTTCTAAAG TATGGCAAGG TCAAGCATTT CATTTAGATA GAAGAAATTC ACCACCAAAT 
AGTTTGACAC CGTGTCTAAA GATTCGGAAT ATGTTTGATC CCGTTATGGA AATAGGGGAT 
CAGTGGCATT TGGCAATTCA AGAAGCAATT TTAGAAAAAT GCAGTGATAA TGATGGCATT 
GTTCACATTG CAGTAGACAA AAATTCACGT GAGGGTTGTG TATATGTTAA ATGTCTGTCT 
CCAGAATATG CTGGAAAGGC TTTTAAAGCA TTGCATGGCT CTTGGTTTGA TGGGAAATTG 
GTTACAGTAA AATATTTACG ACTAGATAGA TACCACCATC GCTTTCCCCA GGCTCTCACT 
TCCAACACTC CATTGAAGCC ATCAAATAAA CATATGAACT CCATGTCTCA TCTTCGTCTT 
CGGACTGGCC TAACCAATTC TCAAGGAAGT TCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structural basis for receptor-regulated SMAD recognition by MAN1.
Nucleic acids research46(22)12139-12153(2018 12)
Miyazono KI,Ohno Y,Wada H,Ito T,Fukatsu Y,Kurisaki A,Asashima M,Tanokura M

LEM domain-containing protein 3 antagonizes TGFβ-SMAD2/3 signaling in a stiffness-dependent manner in both the nucleus and cytosol.
The Journal of biological chemistry293(41)15867-15886(2018 10)
Chambers DM,Moretti L,Zhang JJ,Cooper SW,Chambers DM,Santangelo PJ,Barker TH

Buschke-Ollendorff syndrome due to a novel LEMD3 mutation - an unusual case of alopecia.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG16(3)348-349(2018 Mar)
Darr-Foit S,Schliemann S,Schulz S,Elsner P

The Role of the Nuclear Envelope Protein MAN1 in Mesenchymal Stem Cell Differentiation.
Journal of cellular biochemistry118(12)4425-4435(2017 12)
Bermeo S,Al-Saedi A,Kassem M,Vidal C,Duque G

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

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LEMD3 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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