FBXL7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FBXL7
Entrez Gene ID	23194
Full Name	F-box and leucine rich repeat protein 7
Synonyms	FBL6,FBL7
General protein information	Preferred Names F-box and leucine rich repeat protein 7 Names F-box/LRR-repeat protein 7 F-box protein Fbl7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5p15.1
Summary	This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013].
Disorder MIM:	605656

mRNA and Protein(s)

mRNA	Protein	Name
XM_017009262.2	XP_016864751.1	F-box/LRR-repeat protein 7 isoform X1
NM_012304.4	NP_036436.1	F-box/LRR-repeat protein 7 isoform 1
NM_012304.5	NP_036436.1	F-box/LRR-repeat protein 7 isoform 1
NM_001278317.1	NP_001265246.1	F-box/LRR-repeat protein 7 isoform 2
XM_011513998.1	XP_011512300.1	F-box/LRR-repeat protein 7 isoform X2
XM_017009262.1	XP_016864751.1	F-box/LRR-repeat protein 7 isoform X1

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	FBXL7	XP_001087468.1
Canis lupus familiaris (dog)	FBXL7	XP_005619483.1
Drosophila melanogaster (fruit fly)	CG4221	NP_650512.1
Pan troglodytes (chimpanzee)	FBXL7	XP_001148598.1
Bos taurus (cattle)	FBXL7	XP_002696492.2
Gallus gallus (chicken)	FBXL7	XP_004935160.1
Danio rerio (zebrafish)	zgc:158346	NP_001073511.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003285	XP_307793.5
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012769	XP_306070.4
Homo sapiens (human)	FBXL7	NP_036436.1
Mus musculus (house mouse)	Fbxl7	NP_795933.2
Xenopus tropicalis (tropical clawed frog)	fbxl7	XP_002933169.1
Rattus norvegicus (Norway rat)	Fbxl7	NP_001102015.1

Gene Ontology
Bibliography

Related articles in PubMed

Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.
Kamran M, Long ZJ, Xu D, Lv SS, Liu B, Wang CL, Xu J, Lam EW, Liu Q
Oncogenesis6(2)e298(2017 Feb)

The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin.
Liu Y, Lear T, Iannone O, Shiva S, Corey C, Rajbhandari S, Jerome J, Chen BB, Mallampalli RK
The Journal of biological chemistry290(19)11843-52(2015 May)

F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7.
Liu Y, Lear T, Zhao Y, Zhao J, Zou C, Chen BB, Mallampalli RK
Cell death & disease6e1630(2015 Feb)

Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids.
Park HW, Dahlin A, Tse S, Duan QL, Schuemann B, Martinez FD, Peters SP, Szefler SJ, Lima JJ, Kubo M, Tamari M, Tantisira KG
The Journal of allergy and clinical immunology133(3)664-9.e5(2014 Mar)

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA, Butte NF
PloS one7(12)e51954(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following FBXL7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FBXL7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07690	NM_001278317.1 Latest version!	Homo sapiens F-box and leucine rich repeat protein 7 (FBXL7), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu07690	XM_011513998.1 Latest version!	Homo sapiens F-box and leucine rich repeat protein 7 (FBXL7), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu39299	XM_017009262.2 Latest version!	Homo sapiens F-box and leucine rich repeat protein 7 (FBXL7), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu00486	NM_012304.5 Latest version!	Homo sapiens F-box and leucine rich repeat protein 7 (FBXL7), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
View Old Accession Versions >>
OHu00486	NM_012304.4	Homo sapiens F-box and leucine rich repeat protein 7 (FBXL7), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu39299	XM_017009262.1	Homo sapiens F-box and leucine-rich repeat protein 7 (FBXL7), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FBXL7 ( NM_012304.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036436.1 Homo sapiens F-box and leucine rich repeat protein 7 (FBXL7), transcript variant 1, mRNA.

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CloneID	OHu00486
Clone ID Related Accession (Same CDS sequence)	NM_012304.4 , NM_012304.5
Accession Version	NM_012304.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1476bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506873600000
Organism	Homo sapiens(human)
Product	F-box/LRR-repeat protein 7 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB020647.2 and BU633031.1. On May 31, 2013 this sequence version replaced NM_012304.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB020647.2, BC136424.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCGCGA ACAATGGCAA ACAGTACGGC AGTGAGGGCA AAGGCAGCTC GAGCATCTCA 
TCTGACGTGA GTTCAAGTAC AGATCACACG CCCACTAAAG CCCAGAAGAA TGTGGCTACC 
AGCGAAGACT CCGACCTGAG CATGCGCACA CTGAGCACGC CCAGCCCAGC CCTGATATGT 
CCACCGAATC TCCCAGGATT TCAGAATGGA AGGGGCTCGT CCACCTCCTC GTCCTCCATC 
ACCGGGGAGA CGGTGGCCAT GGTGCACTCC CCGCCCCCGA CCCGCCTCAC ACACCCGCTC 
ATCCGGCTCG CCTCCAGACC CCAGAAGGAG CAGGCCAGCA TAGACCGGCT CCCGGACCAC 
TCCATGGTGC AGATCTTCTC CTTCCTGCCC ACCAACCAGC TGTGCCGCTG CGCGCGAGTG 
TGCCGCCGCT GGTACAACCT GGCCTGGGAC CCGCGGCTCT GGAGGACTAT CCGCCTGACG 
GGCGAGACCA TCAACGTGGA CCGCGCCCTC AAGGTGCTGA CCCGCAGACT CTGCCAGGAC 
ACCCCCAACG TGTGTCTCAT GCTGGAAACC GTAACTGTCA GTGGCTGCAG GCGGCTCACA 
GACCGAGGGC TGTACACCAT CGCCCAGTGC TGCCCCGAAC TGAGGCGACT GGAAGTCTCA 
GGCTGTTACA ATATCTCCAA CGAGGCCGTC TTTGATGTGG TGTCCCTCTG CCCTAATCTG 
GAGCACCTGG ATGTGTCAGG ATGCTCCAAA GTGACCTGCA TCAGCTTGAC CCGGGAGGCC 
TCCATTAAAC TGTCACCCTT GCATGGCAAA CAGATTTCCA TCCGCTACCT GGACATGACG 
GACTGCTTCG TGCTGGAGGA CGAAGGCCTG CACACCATCG CGGCGCACTG CACGCAGCTC 
ACCCACCTCT ACCTGCGCCG CTGCGTCCGC CTGACCGACG AAGGCCTGCG CTACCTGGTG 
ATCTACTGCG CCTCCATCAA GGAGCTGAGC GTCAGCGACT GCCGCTTCGT CAGCGACTTC 
GGCCTGCGGG AGATCGCCAA GCTGGAGTCC CGCCTGCGGT ACCTGAGCAT CGCGCACTGC 
GGCCGGGTCA CCGACGTGGG CATCCGCTAC GTGGCCAAGT ACTGCAGCAA GCTGCGCTAC 
CTCAACGCGA GGGGCTGCGA GGGCATCACG GACCACGGTG TGGAGTACCT CGCCAAGAAC 
TGCACCAAAC TCAAATCCCT GGATATCGGC AAATGCCCTT TGGTATCCGA CACGGGCCTG 
GAGTGCCTGG CCCTGAACTG CTTCAACCTC AAGCGGCTCA GCCTCAAGTC CTGCGAGAGC 
ATCACCGGCC AGGGCTTGCA GATCGTGGCC GCCAACTGCT TTGACCTCCA GACGCTGAAT 
GTCCAGGACT GCGAGGTCTC CGTGGAGGCC CTGCGCTTTG TCAAACGCCA CTGCAAGCGC 
TGCGTCATCG AGCACACCAA CCCGGCTTTC TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036436.1
CDS	482..1957
Translation	MGANNGKQYGSEGKGSSSISSDVSSSTDHTPTKAQKNVATSEDSDLSMRTLSTPSPALICPPNLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF

Target ORF information:

RefSeq Version	NM_012304.4
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and leucine rich repeat protein 7 (FBXL7), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012304.4

ORF Insert Sequence:

ATGGGCGCGA ACAATGGCAA ACAGTACGGC AGTGAGGGCA AAGGCAGCTC GAGCATCTCA 
TCTGACGTGA GTTCAAGTAC AGATCACACG CCCACTAAAG CCCAGAAGAA TGTGGCTACC 
AGCGAAGACT CCGACCTGAG CATGCGCACA CTGAGCACGC CCAGCCCAGC CCTGATATGT 
CCACCGAATC TCCCAGGATT TCAGAATGGA AGGGGCTCGT CCACCTCCTC GTCCTCCATC 
ACCGGGGAGA CGGTGGCCAT GGTGCACTCC CCGCCCCCGA CCCGCCTCAC ACACCCGCTC 
ATCCGGCTCG CCTCCAGACC CCAGAAGGAG CAGGCCAGCA TAGACCGGCT CCCGGACCAC 
TCCATGGTGC AGATCTTCTC CTTCCTGCCC ACCAACCAGC TGTGCCGCTG CGCGCGAGTG 
TGCCGCCGCT GGTACAACCT GGCCTGGGAC CCGCGGCTCT GGAGGACTAT CCGCCTGACG 
GGCGAGACCA TCAACGTGGA CCGCGCCCTC AAGGTGCTGA CCCGCAGACT CTGCCAGGAC 
ACCCCCAACG TGTGTCTCAT GCTGGAAACC GTAACTGTCA GTGGCTGCAG GCGGCTCACA 
GACCGAGGGC TGTACACCAT CGCCCAGTGC TGCCCCGAAC TGAGGCGACT GGAAGTCTCA 
GGCTGTTACA ATATCTCCAA CGAGGCCGTC TTTGATGTGG TGTCCCTCTG CCCTAATCTG 
GAGCACCTGG ATGTGTCAGG ATGCTCCAAA GTGACCTGCA TCAGCTTGAC CCGGGAGGCC 
TCCATTAAAC TGTCACCCTT GCATGGCAAA CAGATTTCCA TCCGCTACCT GGACATGACG 
GACTGCTTCG TGCTGGAGGA CGAAGGCCTG CACACCATCG CGGCGCACTG CACGCAGCTC 
ACCCACCTCT ACCTGCGCCG CTGCGTCCGC CTGACCGACG AAGGCCTGCG CTACCTGGTG 
ATCTACTGCG CCTCCATCAA GGAGCTGAGC GTCAGCGACT GCCGCTTCGT CAGCGACTTC 
GGCCTGCGGG AGATCGCCAA GCTGGAGTCC CGCCTGCGGT ACCTGAGCAT CGCGCACTGC 
GGCCGGGTCA CCGACGTGGG CATCCGCTAC GTGGCCAAGT ACTGCAGCAA GCTGCGCTAC 
CTCAACGCGA GGGGCTGCGA GGGCATCACG GACCACGGTG TGGAGTACCT CGCCAAGAAC 
TGCACCAAAC TCAAATCCCT GGATATCGGC AAATGCCCTT TGGTATCCGA CACGGGCCTG 
GAGTGCCTGG CCCTGAACTG CTTCAACCTC AAGCGGCTCA GCCTCAAGTC CTGCGAGAGC 
ATCACCGGCC AGGGCTTGCA GATCGTGGCC GCCAACTGCT TTGACCTCCA GACGCTGAAT 
GTCCAGGACT GCGAGGTCTC CGTGGAGGCC CTGCGCTTTG TCAAACGCCA CTGCAAGCGC 
TGCGTCATCG AGCACACCAA CCCGGCTTTC TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXL7 ( NM_001278317.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001265246.1 Homo sapiens F-box and leucine rich repeat protein 7 (FBXL7), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07690
Clone ID Related Accession (Same CDS sequence)	NM_001278317.1 , XM_011513998.1
Accession Version	NM_001278317.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1335bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1570550400000
Organism	Homo sapiens(human)
Product	F-box/LRR-repeat protein 7 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK309585.1, AC010477.8, AB020647.2 and BU633031.1. Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2 which is shorter at the N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK309585.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2156099, SAMN03267753 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGCACAC TGAGCACGCC CAGCCCAGCC CTGATATGTC CACCGAATCT CCCAGGATTT 
CAGAATGGAA GGGGCTCGTC CACCTCCTCG TCCTCCATCA CCGGGGAGAC GGTGGCCATG 
GTGCACTCCC CGCCCCCGAC CCGCCTCACA CACCCGCTCA TCCGGCTCGC CTCCAGACCC 
CAGAAGGAGC AGGCCAGCAT AGACCGGCTC CCGGACCACT CCATGGTGCA GATCTTCTCC 
TTCCTGCCCA CCAACCAGCT GTGCCGCTGC GCGCGAGTGT GCCGCCGCTG GTACAACCTG 
GCCTGGGACC CGCGGCTCTG GAGGACTATC CGCCTGACGG GCGAGACCAT CAACGTGGAC 
CGCGCCCTCA AGGTGCTGAC CCGCAGACTC TGCCAGGACA CCCCCAACGT GTGTCTCATG 
CTGGAAACCG TAACTGTCAG TGGCTGCAGG CGGCTCACAG ACCGAGGGCT GTACACCATC 
GCCCAGTGCT GCCCCGAACT GAGGCGACTG GAAGTCTCAG GCTGTTACAA TATCTCCAAC 
GAGGCCGTCT TTGATGTGGT GTCCCTCTGC CCTAATCTGG AGCACCTGGA TGTGTCAGGA 
TGCTCCAAAG TGACCTGCAT CAGCTTGACC CGGGAGGCCT CCATTAAACT GTCACCCTTG 
CATGGCAAAC AGATTTCCAT CCGCTACCTG GACATGACGG ACTGCTTCGT GCTGGAGGAC 
GAAGGCCTGC ACACCATCGC GGCGCACTGC ACGCAGCTCA CCCACCTCTA CCTGCGCCGC 
TGCGTCCGCC TGACCGACGA AGGCCTGCGC TACCTGGTGA TCTACTGCGC CTCCATCAAG 
GAGCTGAGCG TCAGCGACTG CCGCTTCGTC AGCGACTTCG GCCTGCGGGA GATCGCCAAG 
CTGGAGTCCC GCCTGCGGTA CCTGAGCATC GCGCACTGCG GCCGGGTCAC CGACGTGGGC 
ATCCGCTACG TGGCCAAGTA CTGCAGCAAG CTGCGCTACC TCAACGCGAG GGGCTGCGAG 
GGCATCACGG ACCACGGTGT GGAGTACCTC GCCAAGAACT GCACCAAACT CAAATCCCTG 
GATATCGGCA AATGCCCTTT GGTATCCGAC ACGGGCCTGG AGTGCCTGGC CCTGAACTGC 
TTCAACCTCA AGCGGCTCAG CCTCAAGTCC TGCGAGAGCA TCACCGGCCA GGGCTTGCAG 
ATCGTGGCCG CCAACTGCTT TGACCTCCAG ACGCTGAATG TCCAGGACTG CGAGGTCTCC 
GTGGAGGCCC TGCGCTTTGT CAAACGCCAC TGCAAGCGCT GCGTCATCGA GCACACCAAC 
CCGGCTTTCT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265246.1
CDS	391..1725
Translation	MRTLSTPSPALICPPNLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF

Target ORF information:

RefSeq Version	NM_001278317.1
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and leucine rich repeat protein 7 (FBXL7), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278317.1

ORF Insert Sequence:

ATGCGCACAC TGAGCACGCC CAGCCCAGCC CTGATATGTC CACCGAATCT CCCAGGATTT 
CAGAATGGAA GGGGCTCGTC CACCTCCTCG TCCTCCATCA CCGGGGAGAC GGTGGCCATG 
GTGCACTCCC CGCCCCCGAC CCGCCTCACA CACCCGCTCA TCCGGCTCGC CTCCAGACCC 
CAGAAGGAGC AGGCCAGCAT AGACCGGCTC CCGGACCACT CCATGGTGCA GATCTTCTCC 
TTCCTGCCCA CCAACCAGCT GTGCCGCTGC GCGCGAGTGT GCCGCCGCTG GTACAACCTG 
GCCTGGGACC CGCGGCTCTG GAGGACTATC CGCCTGACGG GCGAGACCAT CAACGTGGAC 
CGCGCCCTCA AGGTGCTGAC CCGCAGACTC TGCCAGGACA CCCCCAACGT GTGTCTCATG 
CTGGAAACCG TAACTGTCAG TGGCTGCAGG CGGCTCACAG ACCGAGGGCT GTACACCATC 
GCCCAGTGCT GCCCCGAACT GAGGCGACTG GAAGTCTCAG GCTGTTACAA TATCTCCAAC 
GAGGCCGTCT TTGATGTGGT GTCCCTCTGC CCTAATCTGG AGCACCTGGA TGTGTCAGGA 
TGCTCCAAAG TGACCTGCAT CAGCTTGACC CGGGAGGCCT CCATTAAACT GTCACCCTTG 
CATGGCAAAC AGATTTCCAT CCGCTACCTG GACATGACGG ACTGCTTCGT GCTGGAGGAC 
GAAGGCCTGC ACACCATCGC GGCGCACTGC ACGCAGCTCA CCCACCTCTA CCTGCGCCGC 
TGCGTCCGCC TGACCGACGA AGGCCTGCGC TACCTGGTGA TCTACTGCGC CTCCATCAAG 
GAGCTGAGCG TCAGCGACTG CCGCTTCGTC AGCGACTTCG GCCTGCGGGA GATCGCCAAG 
CTGGAGTCCC GCCTGCGGTA CCTGAGCATC GCGCACTGCG GCCGGGTCAC CGACGTGGGC 
ATCCGCTACG TGGCCAAGTA CTGCAGCAAG CTGCGCTACC TCAACGCGAG GGGCTGCGAG 
GGCATCACGG ACCACGGTGT GGAGTACCTC GCCAAGAACT GCACCAAACT CAAATCCCTG 
GATATCGGCA AATGCCCTTT GGTATCCGAC ACGGGCCTGG AGTGCCTGGC CCTGAACTGC 
TTCAACCTCA AGCGGCTCAG CCTCAAGTCC TGCGAGAGCA TCACCGGCCA GGGCTTGCAG 
ATCGTGGCCG CCAACTGCTT TGACCTCCAG ACGCTGAATG TCCAGGACTG CGAGGTCTCC 
GTGGAGGCCC TGCGCTTTGT CAAACGCCAC TGCAAGCGCT GCGTCATCGA GCACACCAAC 
CCGGCTTTCT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXL7 ( XM_011513998.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011512300.1 Homo sapiens F-box and leucine rich repeat protein 7 (FBXL7), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu07690
Clone ID Related Accession (Same CDS sequence)	NM_001278317.1 , XM_011513998.1
Accession Version	XM_011513998.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1335bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	F-box/LRR-repeat protein 7 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGCACAC TGAGCACGCC CAGCCCAGCC CTGATATGTC CACCGAATCT CCCAGGATTT 
CAGAATGGAA GGGGCTCGTC CACCTCCTCG TCCTCCATCA CCGGGGAGAC GGTGGCCATG 
GTGCACTCCC CGCCCCCGAC CCGCCTCACA CACCCGCTCA TCCGGCTCGC CTCCAGACCC 
CAGAAGGAGC AGGCCAGCAT AGACCGGCTC CCGGACCACT CCATGGTGCA GATCTTCTCC 
TTCCTGCCCA CCAACCAGCT GTGCCGCTGC GCGCGAGTGT GCCGCCGCTG GTACAACCTG 
GCCTGGGACC CGCGGCTCTG GAGGACTATC CGCCTGACGG GCGAGACCAT CAACGTGGAC 
CGCGCCCTCA AGGTGCTGAC CCGCAGACTC TGCCAGGACA CCCCCAACGT GTGTCTCATG 
CTGGAAACCG TAACTGTCAG TGGCTGCAGG CGGCTCACAG ACCGAGGGCT GTACACCATC 
GCCCAGTGCT GCCCCGAACT GAGGCGACTG GAAGTCTCAG GCTGTTACAA TATCTCCAAC 
GAGGCCGTCT TTGATGTGGT GTCCCTCTGC CCTAATCTGG AGCACCTGGA TGTGTCAGGA 
TGCTCCAAAG TGACCTGCAT CAGCTTGACC CGGGAGGCCT CCATTAAACT GTCACCCTTG 
CATGGCAAAC AGATTTCCAT CCGCTACCTG GACATGACGG ACTGCTTCGT GCTGGAGGAC 
GAAGGCCTGC ACACCATCGC GGCGCACTGC ACGCAGCTCA CCCACCTCTA CCTGCGCCGC 
TGCGTCCGCC TGACCGACGA AGGCCTGCGC TACCTGGTGA TCTACTGCGC CTCCATCAAG 
GAGCTGAGCG TCAGCGACTG CCGCTTCGTC AGCGACTTCG GCCTGCGGGA GATCGCCAAG 
CTGGAGTCCC GCCTGCGGTA CCTGAGCATC GCGCACTGCG GCCGGGTCAC CGACGTGGGC 
ATCCGCTACG TGGCCAAGTA CTGCAGCAAG CTGCGCTACC TCAACGCGAG GGGCTGCGAG 
GGCATCACGG ACCACGGTGT GGAGTACCTC GCCAAGAACT GCACCAAACT CAAATCCCTG 
GATATCGGCA AATGCCCTTT GGTATCCGAC ACGGGCCTGG AGTGCCTGGC CCTGAACTGC 
TTCAACCTCA AGCGGCTCAG CCTCAAGTCC TGCGAGAGCA TCACCGGCCA GGGCTTGCAG 
ATCGTGGCCG CCAACTGCTT TGACCTCCAG ACGCTGAATG TCCAGGACTG CGAGGTCTCC 
GTGGAGGCCC TGCGCTTTGT CAAACGCCAC TGCAAGCGCT GCGTCATCGA GCACACCAAC 
CCGGCTTTCT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011512300.1
CDS	182..1516
Translation	MRTLSTPSPALICPPNLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF

Target ORF information:

RefSeq Version	XM_011513998.1
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and leucine rich repeat protein 7 (FBXL7), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011513998.1

ORF Insert Sequence:

ATGCGCACAC TGAGCACGCC CAGCCCAGCC CTGATATGTC CACCGAATCT CCCAGGATTT 
CAGAATGGAA GGGGCTCGTC CACCTCCTCG TCCTCCATCA CCGGGGAGAC GGTGGCCATG 
GTGCACTCCC CGCCCCCGAC CCGCCTCACA CACCCGCTCA TCCGGCTCGC CTCCAGACCC 
CAGAAGGAGC AGGCCAGCAT AGACCGGCTC CCGGACCACT CCATGGTGCA GATCTTCTCC 
TTCCTGCCCA CCAACCAGCT GTGCCGCTGC GCGCGAGTGT GCCGCCGCTG GTACAACCTG 
GCCTGGGACC CGCGGCTCTG GAGGACTATC CGCCTGACGG GCGAGACCAT CAACGTGGAC 
CGCGCCCTCA AGGTGCTGAC CCGCAGACTC TGCCAGGACA CCCCCAACGT GTGTCTCATG 
CTGGAAACCG TAACTGTCAG TGGCTGCAGG CGGCTCACAG ACCGAGGGCT GTACACCATC 
GCCCAGTGCT GCCCCGAACT GAGGCGACTG GAAGTCTCAG GCTGTTACAA TATCTCCAAC 
GAGGCCGTCT TTGATGTGGT GTCCCTCTGC CCTAATCTGG AGCACCTGGA TGTGTCAGGA 
TGCTCCAAAG TGACCTGCAT CAGCTTGACC CGGGAGGCCT CCATTAAACT GTCACCCTTG 
CATGGCAAAC AGATTTCCAT CCGCTACCTG GACATGACGG ACTGCTTCGT GCTGGAGGAC 
GAAGGCCTGC ACACCATCGC GGCGCACTGC ACGCAGCTCA CCCACCTCTA CCTGCGCCGC 
TGCGTCCGCC TGACCGACGA AGGCCTGCGC TACCTGGTGA TCTACTGCGC CTCCATCAAG 
GAGCTGAGCG TCAGCGACTG CCGCTTCGTC AGCGACTTCG GCCTGCGGGA GATCGCCAAG 
CTGGAGTCCC GCCTGCGGTA CCTGAGCATC GCGCACTGCG GCCGGGTCAC CGACGTGGGC 
ATCCGCTACG TGGCCAAGTA CTGCAGCAAG CTGCGCTACC TCAACGCGAG GGGCTGCGAG 
GGCATCACGG ACCACGGTGT GGAGTACCTC GCCAAGAACT GCACCAAACT CAAATCCCTG 
GATATCGGCA AATGCCCTTT GGTATCCGAC ACGGGCCTGG AGTGCCTGGC CCTGAACTGC 
TTCAACCTCA AGCGGCTCAG CCTCAAGTCC TGCGAGAGCA TCACCGGCCA GGGCTTGCAG 
ATCGTGGCCG CCAACTGCTT TGACCTCCAG ACGCTGAATG TCCAGGACTG CGAGGTCTCC 
GTGGAGGCCC TGCGCTTTGT CAAACGCCAC TGCAAGCGCT GCGTCATCGA GCACACCAAC 
CCGGCTTTCT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXL7 ( XM_017009262.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016864751.1 Homo sapiens F-box and leucine rich repeat protein 7 (FBXL7), transcript variant X1, mRNA.

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CloneID	OHu39299
Clone ID Related Accession (Same CDS sequence)	XM_017009262.2 , XM_017009262.1
Accession Version	XM_017009262.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1461bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	F-box/LRR-repeat protein 7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017009262.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCTATC TCAGTTGCCC AGGCAAAGGC AGCTCGAGCA TCTCATCTGA CGTGAGTTCA 
AGTACAGATC ACACGCCCAC TAAAGCCCAG AAGAATGTGG CTACCAGCGA AGACTCCGAC 
CTGAGCATGC GCACACTGAG CACGCCCAGC CCAGCCCTGA TATGTCCACC GAATCTCCCA 
GGATTTCAGA ATGGAAGGGG CTCGTCCACC TCCTCGTCCT CCATCACCGG GGAGACGGTG 
GCCATGGTGC ACTCCCCGCC CCCGACCCGC CTCACACACC CGCTCATCCG GCTCGCCTCC 
AGACCCCAGA AGGAGCAGGC CAGCATAGAC CGGCTCCCGG ACCACTCCAT GGTGCAGATC 
TTCTCCTTCC TGCCCACCAA CCAGCTGTGC CGCTGCGCGC GAGTGTGCCG CCGCTGGTAC 
AACCTGGCCT GGGACCCGCG GCTCTGGAGG ACTATCCGCC TGACGGGCGA GACCATCAAC 
GTGGACCGCG CCCTCAAGGT GCTGACCCGC AGACTCTGCC AGGACACCCC CAACGTGTGT 
CTCATGCTGG AAACCGTAAC TGTCAGTGGC TGCAGGCGGC TCACAGACCG AGGGCTGTAC 
ACCATCGCCC AGTGCTGCCC CGAACTGAGG CGACTGGAAG TCTCAGGCTG TTACAATATC 
TCCAACGAGG CCGTCTTTGA TGTGGTGTCC CTCTGCCCTA ATCTGGAGCA CCTGGATGTG 
TCAGGATGCT CCAAAGTGAC CTGCATCAGC TTGACCCGGG AGGCCTCCAT TAAACTGTCA 
CCCTTGCATG GCAAACAGAT TTCCATCCGC TACCTGGACA TGACGGACTG CTTCGTGCTG 
GAGGACGAAG GCCTGCACAC CATCGCGGCG CACTGCACGC AGCTCACCCA CCTCTACCTG 
CGCCGCTGCG TCCGCCTGAC CGACGAAGGC CTGCGCTACC TGGTGATCTA CTGCGCCTCC 
ATCAAGGAGC TGAGCGTCAG CGACTGCCGC TTCGTCAGCG ACTTCGGCCT GCGGGAGATC 
GCCAAGCTGG AGTCCCGCCT GCGGTACCTG AGCATCGCGC ACTGCGGCCG GGTCACCGAC 
GTGGGCATCC GCTACGTGGC CAAGTACTGC AGCAAGCTGC GCTACCTCAA CGCGAGGGGC 
TGCGAGGGCA TCACGGACCA CGGTGTGGAG TACCTCGCCA AGAACTGCAC CAAACTCAAA 
TCCCTGGATA TCGGCAAATG CCCTTTGGTA TCCGACACGG GCCTGGAGTG CCTGGCCCTG 
AACTGCTTCA ACCTCAAGCG GCTCAGCCTC AAGTCCTGCG AGAGCATCAC CGGCCAGGGC 
TTGCAGATCG TGGCCGCCAA CTGCTTTGAC CTCCAGACGC TGAATGTCCA GGACTGCGAG 
GTCTCCGTGG AGGCCCTGCG CTTTGTCAAA CGCCACTGCA AGCGCTGCGT CATCGAGCAC 
ACCAACCCGG CTTTCTTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016864751.1
CDS	4716..6176
Translation	MVYLSCPGKGSSSISSDVSSSTDHTPTKAQKNVATSEDSDLSMRTLSTPSPALICPPNLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF

Target ORF information:

RefSeq Version	XM_017009262.2
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and leucine rich repeat protein 7 (FBXL7), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017009262.2

ORF Insert Sequence:

ATGGTCTATC TCAGTTGCCC AGGCAAAGGC AGCTCGAGCA TCTCATCTGA CGTGAGTTCA 
AGTACAGATC ACACGCCCAC TAAAGCCCAG AAGAATGTGG CTACCAGCGA AGACTCCGAC 
CTGAGCATGC GCACACTGAG CACGCCCAGC CCAGCCCTGA TATGTCCACC GAATCTCCCA 
GGATTTCAGA ATGGAAGGGG CTCGTCCACC TCCTCGTCCT CCATCACCGG GGAGACGGTG 
GCCATGGTGC ACTCCCCGCC CCCGACCCGC CTCACACACC CGCTCATCCG GCTCGCCTCC 
AGACCCCAGA AGGAGCAGGC CAGCATAGAC CGGCTCCCGG ACCACTCCAT GGTGCAGATC 
TTCTCCTTCC TGCCCACCAA CCAGCTGTGC CGCTGCGCGC GAGTGTGCCG CCGCTGGTAC 
AACCTGGCCT GGGACCCGCG GCTCTGGAGG ACTATCCGCC TGACGGGCGA GACCATCAAC 
GTGGACCGCG CCCTCAAGGT GCTGACCCGC AGACTCTGCC AGGACACCCC CAACGTGTGT 
CTCATGCTGG AAACCGTAAC TGTCAGTGGC TGCAGGCGGC TCACAGACCG AGGGCTGTAC 
ACCATCGCCC AGTGCTGCCC CGAACTGAGG CGACTGGAAG TCTCAGGCTG TTACAATATC 
TCCAACGAGG CCGTCTTTGA TGTGGTGTCC CTCTGCCCTA ATCTGGAGCA CCTGGATGTG 
TCAGGATGCT CCAAAGTGAC CTGCATCAGC TTGACCCGGG AGGCCTCCAT TAAACTGTCA 
CCCTTGCATG GCAAACAGAT TTCCATCCGC TACCTGGACA TGACGGACTG CTTCGTGCTG 
GAGGACGAAG GCCTGCACAC CATCGCGGCG CACTGCACGC AGCTCACCCA CCTCTACCTG 
CGCCGCTGCG TCCGCCTGAC CGACGAAGGC CTGCGCTACC TGGTGATCTA CTGCGCCTCC 
ATCAAGGAGC TGAGCGTCAG CGACTGCCGC TTCGTCAGCG ACTTCGGCCT GCGGGAGATC 
GCCAAGCTGG AGTCCCGCCT GCGGTACCTG AGCATCGCGC ACTGCGGCCG GGTCACCGAC 
GTGGGCATCC GCTACGTGGC CAAGTACTGC AGCAAGCTGC GCTACCTCAA CGCGAGGGGC 
TGCGAGGGCA TCACGGACCA CGGTGTGGAG TACCTCGCCA AGAACTGCAC CAAACTCAAA 
TCCCTGGATA TCGGCAAATG CCCTTTGGTA TCCGACACGG GCCTGGAGTG CCTGGCCCTG 
AACTGCTTCA ACCTCAAGCG GCTCAGCCTC AAGTCCTGCG AGAGCATCAC CGGCCAGGGC 
TTGCAGATCG TGGCCGCCAA CTGCTTTGAC CTCCAGACGC TGAATGTCCA GGACTGCGAG 
GTCTCCGTGG AGGCCCTGCG CTTTGTCAAA CGCCACTGCA AGCGCTGCGT CATCGAGCAC 
ACCAACCCGG CTTTCTTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXL7 ( XM_017009262.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016864751.1 Homo sapiens F-box and leucine-rich repeat protein 7 (FBXL7), transcript variant X1, mRNA.

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CloneID	OHu39299
Clone ID Related Accession (Same CDS sequence)	XM_017009262.2 , XM_017009262.1
Accession Version	XM_017009262.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1461bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1465056000000
Organism	Homo sapiens(human)
Product	F-box/LRR-repeat protein 7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCTATC TCAGTTGCCC AGGCAAAGGC AGCTCGAGCA TCTCATCTGA CGTGAGTTCA 
AGTACAGATC ACACGCCCAC TAAAGCCCAG AAGAATGTGG CTACCAGCGA AGACTCCGAC 
CTGAGCATGC GCACACTGAG CACGCCCAGC CCAGCCCTGA TATGTCCACC GAATCTCCCA 
GGATTTCAGA ATGGAAGGGG CTCGTCCACC TCCTCGTCCT CCATCACCGG GGAGACGGTG 
GCCATGGTGC ACTCCCCGCC CCCGACCCGC CTCACACACC CGCTCATCCG GCTCGCCTCC 
AGACCCCAGA AGGAGCAGGC CAGCATAGAC CGGCTCCCGG ACCACTCCAT GGTGCAGATC 
TTCTCCTTCC TGCCCACCAA CCAGCTGTGC CGCTGCGCGC GAGTGTGCCG CCGCTGGTAC 
AACCTGGCCT GGGACCCGCG GCTCTGGAGG ACTATCCGCC TGACGGGCGA GACCATCAAC 
GTGGACCGCG CCCTCAAGGT GCTGACCCGC AGACTCTGCC AGGACACCCC CAACGTGTGT 
CTCATGCTGG AAACCGTAAC TGTCAGTGGC TGCAGGCGGC TCACAGACCG AGGGCTGTAC 
ACCATCGCCC AGTGCTGCCC CGAACTGAGG CGACTGGAAG TCTCAGGCTG TTACAATATC 
TCCAACGAGG CCGTCTTTGA TGTGGTGTCC CTCTGCCCTA ATCTGGAGCA CCTGGATGTG 
TCAGGATGCT CCAAAGTGAC CTGCATCAGC TTGACCCGGG AGGCCTCCAT TAAACTGTCA 
CCCTTGCATG GCAAACAGAT TTCCATCCGC TACCTGGACA TGACGGACTG CTTCGTGCTG 
GAGGACGAAG GCCTGCACAC CATCGCGGCG CACTGCACGC AGCTCACCCA CCTCTACCTG 
CGCCGCTGCG TCCGCCTGAC CGACGAAGGC CTGCGCTACC TGGTGATCTA CTGCGCCTCC 
ATCAAGGAGC TGAGCGTCAG CGACTGCCGC TTCGTCAGCG ACTTCGGCCT GCGGGAGATC 
GCCAAGCTGG AGTCCCGCCT GCGGTACCTG AGCATCGCGC ACTGCGGCCG GGTCACCGAC 
GTGGGCATCC GCTACGTGGC CAAGTACTGC AGCAAGCTGC GCTACCTCAA CGCGAGGGGC 
TGCGAGGGCA TCACGGACCA CGGTGTGGAG TACCTCGCCA AGAACTGCAC CAAACTCAAA 
TCCCTGGATA TCGGCAAATG CCCTTTGGTA TCCGACACGG GCCTGGAGTG CCTGGCCCTG 
AACTGCTTCA ACCTCAAGCG GCTCAGCCTC AAGTCCTGCG AGAGCATCAC CGGCCAGGGC 
TTGCAGATCG TGGCCGCCAA CTGCTTTGAC CTCCAGACGC TGAATGTCCA GGACTGCGAG 
GTCTCCGTGG AGGCCCTGCG CTTTGTCAAA CGCCACTGCA AGCGCTGCGT CATCGAGCAC 
ACCAACCCGG CTTTCTTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016864751.1
CDS	4477..5937
Translation	MVYLSCPGKGSSSISSDVSSSTDHTPTKAQKNVATSEDSDLSMRTLSTPSPALICPPNLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF

Target ORF information:

RefSeq Version	XM_017009262.1
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and leucine-rich repeat protein 7 (FBXL7), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017009262.1

ORF Insert Sequence:

ATGGTCTATC TCAGTTGCCC AGGCAAAGGC AGCTCGAGCA TCTCATCTGA CGTGAGTTCA 
AGTACAGATC ACACGCCCAC TAAAGCCCAG AAGAATGTGG CTACCAGCGA AGACTCCGAC 
CTGAGCATGC GCACACTGAG CACGCCCAGC CCAGCCCTGA TATGTCCACC GAATCTCCCA 
GGATTTCAGA ATGGAAGGGG CTCGTCCACC TCCTCGTCCT CCATCACCGG GGAGACGGTG 
GCCATGGTGC ACTCCCCGCC CCCGACCCGC CTCACACACC CGCTCATCCG GCTCGCCTCC 
AGACCCCAGA AGGAGCAGGC CAGCATAGAC CGGCTCCCGG ACCACTCCAT GGTGCAGATC 
TTCTCCTTCC TGCCCACCAA CCAGCTGTGC CGCTGCGCGC GAGTGTGCCG CCGCTGGTAC 
AACCTGGCCT GGGACCCGCG GCTCTGGAGG ACTATCCGCC TGACGGGCGA GACCATCAAC 
GTGGACCGCG CCCTCAAGGT GCTGACCCGC AGACTCTGCC AGGACACCCC CAACGTGTGT 
CTCATGCTGG AAACCGTAAC TGTCAGTGGC TGCAGGCGGC TCACAGACCG AGGGCTGTAC 
ACCATCGCCC AGTGCTGCCC CGAACTGAGG CGACTGGAAG TCTCAGGCTG TTACAATATC 
TCCAACGAGG CCGTCTTTGA TGTGGTGTCC CTCTGCCCTA ATCTGGAGCA CCTGGATGTG 
TCAGGATGCT CCAAAGTGAC CTGCATCAGC TTGACCCGGG AGGCCTCCAT TAAACTGTCA 
CCCTTGCATG GCAAACAGAT TTCCATCCGC TACCTGGACA TGACGGACTG CTTCGTGCTG 
GAGGACGAAG GCCTGCACAC CATCGCGGCG CACTGCACGC AGCTCACCCA CCTCTACCTG 
CGCCGCTGCG TCCGCCTGAC CGACGAAGGC CTGCGCTACC TGGTGATCTA CTGCGCCTCC 
ATCAAGGAGC TGAGCGTCAG CGACTGCCGC TTCGTCAGCG ACTTCGGCCT GCGGGAGATC 
GCCAAGCTGG AGTCCCGCCT GCGGTACCTG AGCATCGCGC ACTGCGGCCG GGTCACCGAC 
GTGGGCATCC GCTACGTGGC CAAGTACTGC AGCAAGCTGC GCTACCTCAA CGCGAGGGGC 
TGCGAGGGCA TCACGGACCA CGGTGTGGAG TACCTCGCCA AGAACTGCAC CAAACTCAAA 
TCCCTGGATA TCGGCAAATG CCCTTTGGTA TCCGACACGG GCCTGGAGTG CCTGGCCCTG 
AACTGCTTCA ACCTCAAGCG GCTCAGCCTC AAGTCCTGCG AGAGCATCAC CGGCCAGGGC 
TTGCAGATCG TGGCCGCCAA CTGCTTTGAC CTCCAGACGC TGAATGTCCA GGACTGCGAG 
GTCTCCGTGG AGGCCCTGCG CTTTGTCAAA CGCCACTGCA AGCGCTGCGT CATCGAGCAC 
ACCAACCCGG CTTTCTTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXL7 ( NM_012304.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_036436.1 Homo sapiens F-box and leucine rich repeat protein 7 (FBXL7), transcript variant 1, mRNA.

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CloneID	OHu00486
Clone ID Related Accession (Same CDS sequence)	NM_012304.4 , NM_012304.5
Accession Version	NM_012304.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1476bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1570636800000
Organism	Homo sapiens(human)
Product	F-box/LRR-repeat protein 7 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC010477.8, AB020647.2 and BU633031.1. On Nov 22, 2018 this sequence version replaced NM_012304.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB020647.2, BC136424.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000504595.2/ ENSP00000423630.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCGCGA ACAATGGCAA ACAGTACGGC AGTGAGGGCA AAGGCAGCTC GAGCATCTCA 
TCTGACGTGA GTTCAAGTAC AGATCACACG CCCACTAAAG CCCAGAAGAA TGTGGCTACC 
AGCGAAGACT CCGACCTGAG CATGCGCACA CTGAGCACGC CCAGCCCAGC CCTGATATGT 
CCACCGAATC TCCCAGGATT TCAGAATGGA AGGGGCTCGT CCACCTCCTC GTCCTCCATC 
ACCGGGGAGA CGGTGGCCAT GGTGCACTCC CCGCCCCCGA CCCGCCTCAC ACACCCGCTC 
ATCCGGCTCG CCTCCAGACC CCAGAAGGAG CAGGCCAGCA TAGACCGGCT CCCGGACCAC 
TCCATGGTGC AGATCTTCTC CTTCCTGCCC ACCAACCAGC TGTGCCGCTG CGCGCGAGTG 
TGCCGCCGCT GGTACAACCT GGCCTGGGAC CCGCGGCTCT GGAGGACTAT CCGCCTGACG 
GGCGAGACCA TCAACGTGGA CCGCGCCCTC AAGGTGCTGA CCCGCAGACT CTGCCAGGAC 
ACCCCCAACG TGTGTCTCAT GCTGGAAACC GTAACTGTCA GTGGCTGCAG GCGGCTCACA 
GACCGAGGGC TGTACACCAT CGCCCAGTGC TGCCCCGAAC TGAGGCGACT GGAAGTCTCA 
GGCTGTTACA ATATCTCCAA CGAGGCCGTC TTTGATGTGG TGTCCCTCTG CCCTAATCTG 
GAGCACCTGG ATGTGTCAGG ATGCTCCAAA GTGACCTGCA TCAGCTTGAC CCGGGAGGCC 
TCCATTAAAC TGTCACCCTT GCATGGCAAA CAGATTTCCA TCCGCTACCT GGACATGACG 
GACTGCTTCG TGCTGGAGGA CGAAGGCCTG CACACCATCG CGGCGCACTG CACGCAGCTC 
ACCCACCTCT ACCTGCGCCG CTGCGTCCGC CTGACCGACG AAGGCCTGCG CTACCTGGTG 
ATCTACTGCG CCTCCATCAA GGAGCTGAGC GTCAGCGACT GCCGCTTCGT CAGCGACTTC 
GGCCTGCGGG AGATCGCCAA GCTGGAGTCC CGCCTGCGGT ACCTGAGCAT CGCGCACTGC 
GGCCGGGTCA CCGACGTGGG CATCCGCTAC GTGGCCAAGT ACTGCAGCAA GCTGCGCTAC 
CTCAACGCGA GGGGCTGCGA GGGCATCACG GACCACGGTG TGGAGTACCT CGCCAAGAAC 
TGCACCAAAC TCAAATCCCT GGATATCGGC AAATGCCCTT TGGTATCCGA CACGGGCCTG 
GAGTGCCTGG CCCTGAACTG CTTCAACCTC AAGCGGCTCA GCCTCAAGTC CTGCGAGAGC 
ATCACCGGCC AGGGCTTGCA GATCGTGGCC GCCAACTGCT TTGACCTCCA GACGCTGAAT 
GTCCAGGACT GCGAGGTCTC CGTGGAGGCC CTGCGCTTTG TCAAACGCCA CTGCAAGCGC 
TGCGTCATCG AGCACACCAA CCCGGCTTTC TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036436.1
CDS	498..1973
Translation	MGANNGKQYGSEGKGSSSISSDVSSSTDHTPTKAQKNVATSEDSDLSMRTLSTPSPALICPPNLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF

Target ORF information:

RefSeq Version	NM_012304.5
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box and leucine rich repeat protein 7 (FBXL7), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012304.5

ORF Insert Sequence:

ATGGGCGCGA ACAATGGCAA ACAGTACGGC AGTGAGGGCA AAGGCAGCTC GAGCATCTCA 
TCTGACGTGA GTTCAAGTAC AGATCACACG CCCACTAAAG CCCAGAAGAA TGTGGCTACC 
AGCGAAGACT CCGACCTGAG CATGCGCACA CTGAGCACGC CCAGCCCAGC CCTGATATGT 
CCACCGAATC TCCCAGGATT TCAGAATGGA AGGGGCTCGT CCACCTCCTC GTCCTCCATC 
ACCGGGGAGA CGGTGGCCAT GGTGCACTCC CCGCCCCCGA CCCGCCTCAC ACACCCGCTC 
ATCCGGCTCG CCTCCAGACC CCAGAAGGAG CAGGCCAGCA TAGACCGGCT CCCGGACCAC 
TCCATGGTGC AGATCTTCTC CTTCCTGCCC ACCAACCAGC TGTGCCGCTG CGCGCGAGTG 
TGCCGCCGCT GGTACAACCT GGCCTGGGAC CCGCGGCTCT GGAGGACTAT CCGCCTGACG 
GGCGAGACCA TCAACGTGGA CCGCGCCCTC AAGGTGCTGA CCCGCAGACT CTGCCAGGAC 
ACCCCCAACG TGTGTCTCAT GCTGGAAACC GTAACTGTCA GTGGCTGCAG GCGGCTCACA 
GACCGAGGGC TGTACACCAT CGCCCAGTGC TGCCCCGAAC TGAGGCGACT GGAAGTCTCA 
GGCTGTTACA ATATCTCCAA CGAGGCCGTC TTTGATGTGG TGTCCCTCTG CCCTAATCTG 
GAGCACCTGG ATGTGTCAGG ATGCTCCAAA GTGACCTGCA TCAGCTTGAC CCGGGAGGCC 
TCCATTAAAC TGTCACCCTT GCATGGCAAA CAGATTTCCA TCCGCTACCT GGACATGACG 
GACTGCTTCG TGCTGGAGGA CGAAGGCCTG CACACCATCG CGGCGCACTG CACGCAGCTC 
ACCCACCTCT ACCTGCGCCG CTGCGTCCGC CTGACCGACG AAGGCCTGCG CTACCTGGTG 
ATCTACTGCG CCTCCATCAA GGAGCTGAGC GTCAGCGACT GCCGCTTCGT CAGCGACTTC 
GGCCTGCGGG AGATCGCCAA GCTGGAGTCC CGCCTGCGGT ACCTGAGCAT CGCGCACTGC 
GGCCGGGTCA CCGACGTGGG CATCCGCTAC GTGGCCAAGT ACTGCAGCAA GCTGCGCTAC 
CTCAACGCGA GGGGCTGCGA GGGCATCACG GACCACGGTG TGGAGTACCT CGCCAAGAAC 
TGCACCAAAC TCAAATCCCT GGATATCGGC AAATGCCCTT TGGTATCCGA CACGGGCCTG 
GAGTGCCTGG CCCTGAACTG CTTCAACCTC AAGCGGCTCA GCCTCAAGTC CTGCGAGAGC 
ATCACCGGCC AGGGCTTGCA GATCGTGGCC GCCAACTGCT TTGACCTCCA GACGCTGAAT 
GTCCAGGACT GCGAGGTCTC CGTGGAGGCC CTGCGCTTTG TCAAACGCCA CTGCAAGCGC 
TGCGTCATCG AGCACACCAA CCCGGCTTTC TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.
Oncogenesis6(2)e298(2017 Feb)
Kamran M,Long ZJ,Xu D,Lv SS,Liu B,Wang CL,Xu J,Lam EW,Liu Q

The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin.
The Journal of biological chemistry290(19)11843-52(2015 May)
Liu Y,Lear T,Iannone O,Shiva S,Corey C,Rajbhandari S,Jerome J,Chen BB,Mallampalli RK

F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7.
Cell death & disease6e1630(2015 Feb)
Liu Y,Lear T,Zhao Y,Zhao J,Zou C,Chen BB,Mallampalli RK

Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids.
The Journal of allergy and clinical immunology133(3)664-9.e5(2014 Mar)
Park HW,Dahlin A,Tse S,Duan QL,Schuemann B,Martinez FD,Peters SP,Szefler SJ,Lima JJ,Kubo M,Tamari M,Tantisira KG

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
PloS one7(12)e51954(2012)
Comuzzie AG,Cole SA,Laston SL,Voruganti VS,Haack K,Gibbs RA,Butte NF

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FBXL7 cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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