| Gene Symbol | FOXF1 |
| Entrez Gene ID | 2294 |
| Full Name | forkhead box F1 |
| Synonyms | ACDMPV,FKHL5,FREAC1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: | |
| Disorder Html: | Alveolar capillary dysplasia with misalignment of pulmonary veins, 265380 (3) |
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FOXF1 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following FOXF1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FOXF1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu23845 Clone ID Related Accession (Same CDS sequence) NM_001451.2 , NM_001451.3 Accession Version NM_001451.2 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1140bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1512403200000 Organism Homo sapiens(human) Product forkhead box protein F1 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB011539.1, BC089442.1 and CA438612.1. This sequence is a reference standard in the RefSeqGene project. On Jul 26, 2006 this sequence version replaced NM_001451.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK314167.1, U13219.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081ATGTCTTCGG CGCCCGAGAA GCAGCAGCCA CCGCACGGCG GCGGCGGCGG CGGCGGCGGG
GGAGGCGGCG CGGCCATGGA CCCCGCGTCG TCCGGCCCGT CCAAGGCCAA GAAGACCAAC
GCCGGCATCC GGCGCCCGGA GAAGCCGCCC TATTCCTACA TCGCGCTCAT CGTCATGGCC
ATCCAGAGTT CACCCACCAA GCGCCTGACG CTGAGCGAGA TCTACCAGTT CCTGCAGAGC
CGCTTCCCCT TCTTCCGGGG CTCCTACCAG GGCTGGAAGA ACTCCGTGCG CCACAACCTC
TCGCTCAACG AGTGCTTCAT CAAGCTACCC AAGGGCCTTG GGCGGCCCGG CAAGGGCCAC
TACTGGACCA TCGACCCGGC CAGCGAGTTC ATGTTCGAGG AGGGCTCCTT TCGGCGGCGG
CCGCGCGGCT TCCGAAGGAA ATGCCAGGCG CTCAAGCCCA TGTACAGCAT GATGAACGGG
CTCGGCTTCA ACCACCTCCC GGACACCTAC GGCTTCCAGG GCTCGGCCGG CGGCCTCTCG
TGCCCGCCCA ACAGCCTGGC GCTGGAGGGC GGCCTGGGCA TGATGAACGG CCACTTGCCG
GGCAACGTGG ACGGCATGGC CCTGCCCAGC CACTCGGTGC CCCACCTGCC TTCCAACGGC
GGCCACTCGT ACATGGGCGG CTGCGGCGGC GCGGCGGCCG GCGAGTACCC GCACCACGAC
AGCTCGGTGC CCGCCTCCCC GCTGCTGCCC ACCGGCGCCG GTGGGGTCAT GGAGCCGCAC
GCCGTCTACT CGGGCTCGGC GGCGGCCTGG CCGCCCTCGG CGTCCGCGGC GCTCAACAGC
GGCGCCTCTT ATATCAAGCA GCAGCCCCTG TCCCCCTGTA ACCCCGCGGC CAACCCCCTG
TCCGGCAGCC TCTCCACGCA CTCCCTGGAG CAGCCGTATC TGCACCAGAA CAGCCACAAC
GCCCCAGCCG AGCTGCAAGG CATCCCGCGG TATCACTCGC AGTCGCCCAG CATGTGTGAC
CGAAAGGAGT TTGTCTTCTC TTTCAACGCC ATGGCGTCCT CTTCCATGCA CTCGGCCGGC
GGGGGCTCCT ACTACCACCA GCAGGTCACC TACCAAGACA TCAAGCCTTG CGTGATGTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001442.2 CDS 44..1183 Translation 
Target ORF information:
RefSeq Version NM_001451.2 Organism Homo sapiens(human) Definition Homo sapiens forkhead box F1 (FOXF1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_001451.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081ATGTCTTCGG CGCCCGAGAA GCAGCAGCCA CCGCACGGCG GCGGCGGCGG CGGCGGCGGG
GGAGGCGGCG CGGCCATGGA CCCCGCGTCG TCCGGCCCGT CCAAGGCCAA GAAGACCAAC
GCCGGCATCC GGCGCCCGGA GAAGCCGCCC TATTCCTACA TCGCGCTCAT CGTCATGGCC
ATCCAGAGTT CACCCACCAA GCGCCTGACG CTGAGCGAGA TCTACCAGTT CCTGCAGAGC
CGCTTCCCCT TCTTCCGGGG CTCCTACCAG GGCTGGAAGA ACTCCGTGCG CCACAACCTC
TCGCTCAACG AGTGCTTCAT CAAGCTACCC AAGGGCCTTG GGCGGCCCGG CAAGGGCCAC
TACTGGACCA TCGACCCGGC CAGCGAGTTC ATGTTCGAGG AGGGCTCCTT TCGGCGGCGG
CCGCGCGGCT TCCGAAGGAA ATGCCAGGCG CTCAAGCCCA TGTACAGCAT GATGAACGGG
CTCGGCTTCA ACCACCTCCC GGACACCTAC GGCTTCCAGG GCTCGGCCGG CGGCCTCTCG
TGCCCGCCCA ACAGCCTGGC GCTGGAGGGC GGCCTGGGCA TGATGAACGG CCACTTGCCG
GGCAACGTGG ACGGCATGGC CCTGCCCAGC CACTCGGTGC CCCACCTGCC TTCCAACGGC
GGCCACTCGT ACATGGGCGG CTGCGGCGGC GCGGCGGCCG GCGAGTACCC GCACCACGAC
AGCTCGGTGC CCGCCTCCCC GCTGCTGCCC ACCGGCGCCG GTGGGGTCAT GGAGCCGCAC
GCCGTCTACT CGGGCTCGGC GGCGGCCTGG CCGCCCTCGG CGTCCGCGGC GCTCAACAGC
GGCGCCTCTT ATATCAAGCA GCAGCCCCTG TCCCCCTGTA ACCCCGCGGC CAACCCCCTG
TCCGGCAGCC TCTCCACGCA CTCCCTGGAG CAGCCGTATC TGCACCAGAA CAGCCACAAC
GCCCCAGCCG AGCTGCAAGG CATCCCGCGG TATCACTCGC AGTCGCCCAG CATGTGTGAC
CGAAAGGAGT TTGTCTTCTC TTTCAACGCC ATGGCGTCCT CTTCCATGCA CTCGGCCGGC
GGGGGCTCCT ACTACCACCA GCAGGTCACC TACCAAGACA TCAAGCCTTG CGTGATGTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu23845 Clone ID Related Accession (Same CDS sequence) NM_001451.2 , NM_001451.3 Accession Version NM_001451.3 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1140bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1576771200000 Organism Homo sapiens(human) Product forkhead box protein F1 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB011539.1, BC089442.1, CA438612.1 and AC009108.10. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001451.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK314167.1, U13219.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000262426.6/ ENSP00000262426.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081ATGTCTTCGG CGCCCGAGAA GCAGCAGCCA CCGCACGGCG GCGGCGGCGG CGGCGGCGGG
GGAGGCGGCG CGGCCATGGA CCCCGCGTCG TCCGGCCCGT CCAAGGCCAA GAAGACCAAC
GCCGGCATCC GGCGCCCGGA GAAGCCGCCC TATTCCTACA TCGCGCTCAT CGTCATGGCC
ATCCAGAGTT CACCCACCAA GCGCCTGACG CTGAGCGAGA TCTACCAGTT CCTGCAGAGC
CGCTTCCCCT TCTTCCGGGG CTCCTACCAG GGCTGGAAGA ACTCCGTGCG CCACAACCTC
TCGCTCAACG AGTGCTTCAT CAAGCTACCC AAGGGCCTTG GGCGGCCCGG CAAGGGCCAC
TACTGGACCA TCGACCCGGC CAGCGAGTTC ATGTTCGAGG AGGGCTCCTT TCGGCGGCGG
CCGCGCGGCT TCCGAAGGAA ATGCCAGGCG CTCAAGCCCA TGTACAGCAT GATGAACGGG
CTCGGCTTCA ACCACCTCCC GGACACCTAC GGCTTCCAGG GCTCGGCCGG CGGCCTCTCG
TGCCCGCCCA ACAGCCTGGC GCTGGAGGGC GGCCTGGGCA TGATGAACGG CCACTTGCCG
GGCAACGTGG ACGGCATGGC CCTGCCCAGC CACTCGGTGC CCCACCTGCC TTCCAACGGC
GGCCACTCGT ACATGGGCGG CTGCGGCGGC GCGGCGGCCG GCGAGTACCC GCACCACGAC
AGCTCGGTGC CCGCCTCCCC GCTGCTGCCC ACCGGCGCCG GTGGGGTCAT GGAGCCGCAC
GCCGTCTACT CGGGCTCGGC GGCGGCCTGG CCGCCCTCGG CGTCCGCGGC GCTCAACAGC
GGCGCCTCTT ATATCAAGCA GCAGCCCCTG TCCCCCTGTA ACCCCGCGGC CAACCCCCTG
TCCGGCAGCC TCTCCACGCA CTCCCTGGAG CAGCCGTATC TGCACCAGAA CAGCCACAAC
GCCCCAGCCG AGCTGCAAGG CATCCCGCGG TATCACTCGC AGTCGCCCAG CATGTGTGAC
CGAAAGGAGT TTGTCTTCTC TTTCAACGCC ATGGCGTCCT CTTCCATGCA CTCGGCCGGC
GGGGGCTCCT ACTACCACCA GCAGGTCACC TACCAAGACA TCAAGCCTTG CGTGATGTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001442.2 CDS 44..1183 Translation
Target ORF information:
RefSeq Version NM_001451.3 Organism Homo sapiens(human) Definition Homo sapiens forkhead box F1 (FOXF1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_001451.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081ATGTCTTCGG CGCCCGAGAA GCAGCAGCCA CCGCACGGCG GCGGCGGCGG CGGCGGCGGG
GGAGGCGGCG CGGCCATGGA CCCCGCGTCG TCCGGCCCGT CCAAGGCCAA GAAGACCAAC
GCCGGCATCC GGCGCCCGGA GAAGCCGCCC TATTCCTACA TCGCGCTCAT CGTCATGGCC
ATCCAGAGTT CACCCACCAA GCGCCTGACG CTGAGCGAGA TCTACCAGTT CCTGCAGAGC
CGCTTCCCCT TCTTCCGGGG CTCCTACCAG GGCTGGAAGA ACTCCGTGCG CCACAACCTC
TCGCTCAACG AGTGCTTCAT CAAGCTACCC AAGGGCCTTG GGCGGCCCGG CAAGGGCCAC
TACTGGACCA TCGACCCGGC CAGCGAGTTC ATGTTCGAGG AGGGCTCCTT TCGGCGGCGG
CCGCGCGGCT TCCGAAGGAA ATGCCAGGCG CTCAAGCCCA TGTACAGCAT GATGAACGGG
CTCGGCTTCA ACCACCTCCC GGACACCTAC GGCTTCCAGG GCTCGGCCGG CGGCCTCTCG
TGCCCGCCCA ACAGCCTGGC GCTGGAGGGC GGCCTGGGCA TGATGAACGG CCACTTGCCG
GGCAACGTGG ACGGCATGGC CCTGCCCAGC CACTCGGTGC CCCACCTGCC TTCCAACGGC
GGCCACTCGT ACATGGGCGG CTGCGGCGGC GCGGCGGCCG GCGAGTACCC GCACCACGAC
AGCTCGGTGC CCGCCTCCCC GCTGCTGCCC ACCGGCGCCG GTGGGGTCAT GGAGCCGCAC
GCCGTCTACT CGGGCTCGGC GGCGGCCTGG CCGCCCTCGG CGTCCGCGGC GCTCAACAGC
GGCGCCTCTT ATATCAAGCA GCAGCCCCTG TCCCCCTGTA ACCCCGCGGC CAACCCCCTG
TCCGGCAGCC TCTCCACGCA CTCCCTGGAG CAGCCGTATC TGCACCAGAA CAGCCACAAC
GCCCCAGCCG AGCTGCAAGG CATCCCGCGG TATCACTCGC AGTCGCCCAG CATGTGTGAC
CGAAAGGAGT TTGTCTTCTC TTTCAACGCC ATGGCGTCCT CTTCCATGCA CTCGGCCGGC
GGGGGCTCCT ACTACCACCA GCAGGTCACC TACCAAGACA TCAAGCCTTG CGTGATGTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Association of rare non-coding SNVs in the lung-specific FOXF1 enhancer with a mitigation of the lethal ACDMPV phenotype.
Human genetics138(11-12)1301-1311(2019 Dec)
Szafranski P,Liu Q,Karolak JA,Song X,de Leeuw N,Faas B,Gerychova R,Janku P,Jezova M,Valaskova I,Gibbs KA,Surrey LF,Poisson V,Bérubé D,Oligny LL,Michaud JL,Popek E,Stankiewicz P
MiR-152-3p regulates cell proliferation, invasion and extracellular matrix expression through by targeting FOXF1 in keloid fibroblasts.
Life sciences234116779(2019 Oct)
Wang R,Bai Z,Wen X,Du H,Zhou L,Tang Z,Yang Z,Ma W
FOXF1 promotes angiogenesis and accelerates bevacizumab resistance in colorectal cancer by transcriptionally activating VEGFA.
Cancer letters43978-90(2018 12)
Wang S,Xiao Z,Hong Z,Jiao H,Zhu S,Zhao Y,Bi J,Qiu J,Zhang D,Yan J,Zhang L,Huang C,Li T,Liang L,Liao W,Ye Y,Ding Y
FOXF1 Induces Epithelial-Mesenchymal Transition in Colorectal Cancer Metastasis by Transcriptionally Activating SNAI1.
Neoplasia (New York, N.Y.)20(10)996-1007(2018 10)
Wang S,Yan S,Zhu S,Zhao Y,Yan J,Xiao Z,Bi J,Qiu J,Zhang D,Hong Z,Zhang L,Huang C,Li T,Liang L,Liao W,Jiao H,Ding Y,Ye Y
Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescence.
Genome biology19(1)118(2018 08)
Han R,Li L,Ugalde AP,Tal A,Manber Z,Barbera EP,Chiara VD,Elkon R,Agami R
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