| Gene Symbol | RPIA |
| Entrez Gene ID | 22934 |
| Full Name | ribose 5-phosphate isomerase A |
| Synonyms | RPI,RPIAD |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene is an enzyme, which catalyzes the reversible conversion between ribose-5-phosphate and ribulose-5-phosphate in the pentose-phosphate pathway. This gene is highly conserved in most organisms. The enzyme plays an essential role in the carbohydrate metabolism. Mutations in this gene cause ribose 5-phosphate isomerase deficiency. A pseudogene is found on chromosome 18. [provided by RefSeq, Mar 2010]. |
| Disorder MIM: | |
| Disorder Html: | ?Ribose 5-phosphate isomerase deficiency, 608611 (3) |
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RPIA cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following RPIA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RPIA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu18642 Clone ID Related Accession (Same CDS sequence) NM_144563.2 , NM_144563.3 Accession Version NM_144563.2 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 936bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1512403200000 Organism Homo sapiens(human) Product ribose-5-phosphate isomerase Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB989690.1, BC015529.1 and BF063086.1. This sequence is a reference standard in the RefSeqGene project. On May 4, 2006 this sequence version replaced NM_144563.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY050633.1, SRR1163658.391040.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901ATGCAGCGCC CCGGGCCCTT CAGCACCCTC TACGGGCGGG TCTTGGCCCC GCTGCCCGGG
AGGGCCGGGG GCGCGGCCTC CGGCGGAGGA GGGAACAGCT GGGACCTCCC GGGTTCCCAC
GTGCGGCTGC CGGGGCGTGC ACAGTCTGGG ACCCGTGGCG GTGCTGGCAA CACAAGCACC
AGCTGCGGGG ACTCCAACAG CATCTGCCCG GCCCCCTCCA CGATGTCCAA GGCCGAGGAG
GCCAAGAAGC TGGCGGGCCG CGCGGCTGTG GAGAACCACG TGAGGAATAA CCAAGTGCTG
GGAATTGGAA GTGGTTCTAC AATTGTCCAT GCTGTGCAGC GAATAGCTGA AAGGGTGAAG
CAAGAGAATC TGAACCTCGT CTGTATTCCC ACTTCCTTCC AGGCCCGCCA GCTCATCCTG
CAGTATGGCT TGACCCTCAG TGATCTGGAT CGACACCCAG AGATCGACCT TGCCATCGAT
GGTGCTGATG AAGTAGATGC TGATCTCAAT CTCATCAAGG GTGGCGGAGG CTGCCTGACC
CAGGAGAAGA TTGTGGCTGG CTATGCTAGT CGCTTCATCG TGATCGCTGA TTTCAGGAAA
GATTCGAAGA ATCTCGGGGA TCAGTGGCAC AAGGGAATCC CCATCGAGGT CATCCCAATG
GCCTATGTCC CAGTGAGCCG AGCTGTGAGC CAGAAGTTTG GGGGCGTGGT TGAACTTCGA
ATGGCTGTCA ACAAGGCTGG TCCTGTGGTG ACAGATAATG GGAATTTTAT CTTGGACTGG
AAGTTTGACC GGGTACACAA ATGGAGTGAA GTGAATACAG CTATCAAAAT GATCCCAGGT
GTGGTGGACA CAGGCCTATT CATCAACATG GCTGAGAGAG TCTACTTTGG GATGCAGGAT
GGCTCAGTGA ACATGAGGGA GAAGCCTTTC TGTTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_653164.2 CDS 42..977 Translation 
Target ORF information:
RefSeq Version NM_144563.2 Organism Homo sapiens(human) Definition Homo sapiens ribose 5-phosphate isomerase A (RPIA), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_144563.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901ATGCAGCGCC CCGGGCCCTT CAGCACCCTC TACGGGCGGG TCTTGGCCCC GCTGCCCGGG
AGGGCCGGGG GCGCGGCCTC CGGCGGAGGA GGGAACAGCT GGGACCTCCC GGGTTCCCAC
GTGCGGCTGC CGGGGCGTGC ACAGTCTGGG ACCCGTGGCG GTGCTGGCAA CACAAGCACC
AGCTGCGGGG ACTCCAACAG CATCTGCCCG GCCCCCTCCA CGATGTCCAA GGCCGAGGAG
GCCAAGAAGC TGGCGGGCCG CGCGGCTGTG GAGAACCACG TGAGGAATAA CCAAGTGCTG
GGAATTGGAA GTGGTTCTAC AATTGTCCAT GCTGTGCAGC GAATAGCTGA AAGGGTGAAG
CAAGAGAATC TGAACCTCGT CTGTATTCCC ACTTCCTTCC AGGCCCGCCA GCTCATCCTG
CAGTATGGCT TGACCCTCAG TGATCTGGAT CGACACCCAG AGATCGACCT TGCCATCGAT
GGTGCTGATG AAGTAGATGC TGATCTCAAT CTCATCAAGG GTGGCGGAGG CTGCCTGACC
CAGGAGAAGA TTGTGGCTGG CTATGCTAGT CGCTTCATCG TGATCGCTGA TTTCAGGAAA
GATTCGAAGA ATCTCGGGGA TCAGTGGCAC AAGGGAATCC CCATCGAGGT CATCCCAATG
GCCTATGTCC CAGTGAGCCG AGCTGTGAGC CAGAAGTTTG GGGGCGTGGT TGAACTTCGA
ATGGCTGTCA ACAAGGCTGG TCCTGTGGTG ACAGATAATG GGAATTTTAT CTTGGACTGG
AAGTTTGACC GGGTACACAA ATGGAGTGAA GTGAATACAG CTATCAAAAT GATCCCAGGT
GTGGTGGACA CAGGCCTATT CATCAACATG GCTGAGAGAG TCTACTTTGG GATGCAGGAT
GGCTCAGTGA ACATGAGGGA GAAGCCTTTC TGTTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu18642 Clone ID Related Accession (Same CDS sequence) NM_144563.2 , NM_144563.3 Accession Version NM_144563.3 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 936bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577635200000 Organism Homo sapiens(human) Product ribose-5-phosphate isomerase Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB989690.1, BC015529.1 and BF063086.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_144563.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.218873.1, SRR3476690.319943.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000283646.5/ ENSP00000283646.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901ATGCAGCGCC CCGGGCCCTT CAGCACCCTC TACGGGCGGG TCTTGGCCCC GCTGCCCGGG
AGGGCCGGGG GCGCGGCCTC CGGCGGAGGA GGGAACAGCT GGGACCTCCC GGGTTCCCAC
GTGCGGCTGC CGGGGCGTGC ACAGTCTGGG ACCCGTGGCG GTGCTGGCAA CACAAGCACC
AGCTGCGGGG ACTCCAACAG CATCTGCCCG GCCCCCTCCA CGATGTCCAA GGCCGAGGAG
GCCAAGAAGC TGGCGGGCCG CGCGGCTGTG GAGAACCACG TGAGGAATAA CCAAGTGCTG
GGAATTGGAA GTGGTTCTAC AATTGTCCAT GCTGTGCAGC GAATAGCTGA AAGGGTGAAG
CAAGAGAATC TGAACCTCGT CTGTATTCCC ACTTCCTTCC AGGCCCGCCA GCTCATCCTG
CAGTATGGCT TGACCCTCAG TGATCTGGAT CGACACCCAG AGATCGACCT TGCCATCGAT
GGTGCTGATG AAGTAGATGC TGATCTCAAT CTCATCAAGG GTGGCGGAGG CTGCCTGACC
CAGGAGAAGA TTGTGGCTGG CTATGCTAGT CGCTTCATCG TGATCGCTGA TTTCAGGAAA
GATTCGAAGA ATCTCGGGGA TCAGTGGCAC AAGGGAATCC CCATCGAGGT CATCCCAATG
GCCTATGTCC CAGTGAGCCG AGCTGTGAGC CAGAAGTTTG GGGGCGTGGT TGAACTTCGA
ATGGCTGTCA ACAAGGCTGG TCCTGTGGTG ACAGATAATG GGAATTTTAT CTTGGACTGG
AAGTTTGACC GGGTACACAA ATGGAGTGAA GTGAATACAG CTATCAAAAT GATCCCAGGT
GTGGTGGACA CAGGCCTATT CATCAACATG GCTGAGAGAG TCTACTTTGG GATGCAGGAT
GGCTCAGTGA ACATGAGGGA GAAGCCTTTC TGTTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_653164.2 CDS 27..962 Translation
Target ORF information:
RefSeq Version NM_144563.3 Organism Homo sapiens(human) Definition Homo sapiens ribose 5-phosphate isomerase A (RPIA), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_144563.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901ATGCAGCGCC CCGGGCCCTT CAGCACCCTC TACGGGCGGG TCTTGGCCCC GCTGCCCGGG
AGGGCCGGGG GCGCGGCCTC CGGCGGAGGA GGGAACAGCT GGGACCTCCC GGGTTCCCAC
GTGCGGCTGC CGGGGCGTGC ACAGTCTGGG ACCCGTGGCG GTGCTGGCAA CACAAGCACC
AGCTGCGGGG ACTCCAACAG CATCTGCCCG GCCCCCTCCA CGATGTCCAA GGCCGAGGAG
GCCAAGAAGC TGGCGGGCCG CGCGGCTGTG GAGAACCACG TGAGGAATAA CCAAGTGCTG
GGAATTGGAA GTGGTTCTAC AATTGTCCAT GCTGTGCAGC GAATAGCTGA AAGGGTGAAG
CAAGAGAATC TGAACCTCGT CTGTATTCCC ACTTCCTTCC AGGCCCGCCA GCTCATCCTG
CAGTATGGCT TGACCCTCAG TGATCTGGAT CGACACCCAG AGATCGACCT TGCCATCGAT
GGTGCTGATG AAGTAGATGC TGATCTCAAT CTCATCAAGG GTGGCGGAGG CTGCCTGACC
CAGGAGAAGA TTGTGGCTGG CTATGCTAGT CGCTTCATCG TGATCGCTGA TTTCAGGAAA
GATTCGAAGA ATCTCGGGGA TCAGTGGCAC AAGGGAATCC CCATCGAGGT CATCCCAATG
GCCTATGTCC CAGTGAGCCG AGCTGTGAGC CAGAAGTTTG GGGGCGTGGT TGAACTTCGA
ATGGCTGTCA ACAAGGCTGG TCCTGTGGTG ACAGATAATG GGAATTTTAT CTTGGACTGG
AAGTTTGACC GGGTACACAA ATGGAGTGAA GTGAATACAG CTATCAAAAT GATCCCAGGT
GTGGTGGACA CAGGCCTATT CATCAACATG GCTGAGAGAG TCTACTTTGG GATGCAGGAT
GGCTCAGTGA ACATGAGGGA GAAGCCTTTC TGTTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Confirmation of a Rare Genetic Leukoencephalopathy due to a Novel Bi-allelic Variant in RPIA.
European journal of medical genetics62(8)103708(2019 Aug)
Kaur P,Wamelink MMC,van der Knaap MS,Girisha KM,Shukla A
Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells.
Scientific reports8(1)13134(2018 09)
Szwarc MM,Kommagani R,Putluri V,Dubrulle J,Stossi F,Mancini MA,Coarfa C,Lanz RB,Putluri N,DeMayo FJ,Lydon JP,O'Malley BW
Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW
Ribose 5-phosphate isomerase inhibits LC3 processing and basal autophagy.
Cellular signalling28(9)1380-8(2016 09)
Heintze J,Costa JR,Weber M,Ketteler R
An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Taşan M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barabási AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M
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