LEMD2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LEMD2
Entrez Gene ID	221496
Full Name	LEM domain containing 2
Synonyms	CTRCT42,NET25,dJ482C21.1
General protein information	Preferred Names LEM domain containing 2 Names LEM domain-containing protein 2 hLEM2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.31
Summary	This gene encodes a LEM domain-containing transmembrane protein of the inner nuclear membrane. The protein is involved in nuclear structure organization and plays a role in cell signaling and differentiation. Mutations in this gene result in Cataract 46, juvenile-onset. Multiple transcript variants have been found for this gene. [provided by RefSeq, Feb 2017].
Disorder MIM:	616312
Disorder Html:	Cataract 46, juvenile-onset, 212500 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_017010437.1	XP_016865926.1	LEM domain-containing protein 2 isoform X1
NM_001348709.2	NP_001335638.1	LEM domain-containing protein 2 isoform 2
NM_001348709.1	NP_001335638.1	LEM domain-containing protein 2 isoform 2
NM_181336.3	NP_851853.1	LEM domain-containing protein 2 isoform 1
NM_001348710.2	NP_001335639.1	LEM domain-containing protein 2 isoform 3
NM_001348710.1	NP_001335639.1	LEM domain-containing protein 2 isoform 3
NM_001143944.1	NP_001137416.1	LEM domain-containing protein 2 isoform 2
NM_181336.4	NP_851853.1	LEM domain-containing protein 2 isoform 1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	LEMD2	XP_418032.2
Homo sapiens (human)	LEMD2	NP_851853.1
Macaca mulatta (Rhesus monkey)	LOC718463	XP_001116367.1
Canis lupus familiaris (dog)	LEMD2	XP_849951.2
Bos taurus (cattle)	LEMD2	NP_001179408.1
Mus musculus (house mouse)	Lemd2	NP_666187.2
Pan troglodytes (chimpanzee)	LEMD2	XP_001171510.1
Rattus norvegicus (Norway rat)	Lemd2	NP_001034121.1

Gene Ontology
Bibliography

Related articles in PubMed

Nuclear envelope localization of LEMD2 is developmentally dynamic and lamin A/C dependent yet insufficient for heterochromatin tethering.
Thanisch K, Song C, Engelkamp D, Koch J, Wang A, Hallberg E, Foisner R, Leonhardt H, Stewart CL, Joffe B, Solovei I
Differentiation; research in biological diversity9458-70(2017 Mar - Apr)

Repair of nuclear ruptures requires barrier-to-autointegration factor.
Halfmann CT, Sears RM, Katiyar A, Busselman BW, Aman LK, Zhang Q, O'Bryan CS, Angelini TE, Lele TP, Roux KJ
The Journal of cell biology218(7)2136-2149(2019 Jul)

LEM-domain proteins are lost during human spermiogenesis but BAF and BAF-L persist.
Elkhatib RA, Paci M, Boissier R, Longepied G, Auguste Y, Achard V, Bourgeois P, Levy N, Branger N, Mitchell MJ, Metzler-Guillemain C
Reproduction (Cambridge, England)154(4)387-401(2017 10)

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells.
Gu M, LaJoie D, Chen OS, von Appen A, Ladinsky MS, Redd MJ, Nikolova L, Bjorkman PJ, Sundquist WI, Ullman KS, Frost A
Proceedings of the National Academy of Sciences of the United States of America114(11)E2166-E2175(2017 03)

Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.
Yang SK, Hong M, Zhao W, Jung Y, Baek J, Tayebi N, Kim KM, Ye BD, Kim KJ, Park SH, Lee I, Lee EJ, Kim WH, Cheon JH, Kim YH, Jang BI, Kim HS, Choi JH, Koo JS, Lee JH, Jung SA, Lee YJ, Jang JY, Shin HD, Kang D, Youn HS, Liu J, Song K
Gut63(1)80-7(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following LEMD2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LEMD2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu101292	NM_001348710.2 Latest version!	Homo sapiens LEM domain nuclear envelope protein 2 (LEMD2), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu96392	XM_017010437.1 Latest version!	Homo sapiens LEM domain nuclear envelope protein 2 (LEMD2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu09042	NM_181336.4 Latest version!	Homo sapiens LEM domain nuclear envelope protein 2 (LEMD2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$307.30 $439.00
OHu09185	NM_001348709.2 Latest version!	Homo sapiens LEM domain nuclear envelope protein 2 (LEMD2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$139.30 $199.00
OHu09185	NM_001143944.1 Latest version!	Homo sapiens LEM domain nuclear envelope protein 2 (LEMD2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$139.30 $199.00
View Old Accession Versions >>
OHu09185	NM_001348709.1	Homo sapiens LEM domain containing 2 (LEMD2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$139.30 $199.00
OHu101292	NM_001348710.1	Homo sapiens LEM domain containing 2 (LEMD2), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu09042	NM_181336.3	Homo sapiens LEM domain containing 2 (LEMD2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LEMD2 ( NM_001348710.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001335639.1 Homo sapiens LEM domain nuclear envelope protein 2 (LEMD2), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu101292
Clone ID Related Accession (Same CDS sequence)	NM_001348710.2 , NM_001348710.1
Accession Version	NM_001348710.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1113bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577980800000
Organism	Homo sapiens(human)
Product	LEM domain-containing protein 2 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL158049.11. On Jun 1, 2019 this sequence version replaced NM_001348710.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.453577.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGGCC TGTCGGACCT GGAACTGCGG CGGGAGCTGC AGGCCCTGGG CTTCCAGCCA 
GGACCCATCA CCGACACCAC CCGGGATGTC TACCGCAACA AGCTGCGCCG CCTGCGGGGC 
GAGGCCCGGC TGCGCGACGA GGAGCGGCTG CGGGAGGAGG CCCGGCCGCG GGGCGAGGAG 
CGGTTACGGG AAGAGGCCCG GTTACGCGAG GATGCGCCGC TGCGCGCCCG GCCCGCCGCG 
GCCTCTCCGC GGGCGGAGCC CTGGCTCTCC CAGCCGGCCT CGGGCTCGGC CTACGCGACC 
CCTGGGGCCT ACGGTGATAT CCGGCCCTCC GCGGCTTCCT GGTTATTGCC AGTGGACTGT 
GAGAGAAAAA CAGATGAGTT CTGTCAGGCC AAGCAGAAGG CAGCCTTGCT GGAGCTGCTG 
CATGAACTCT ACAATTTCCT GGCCATCCAA GCTGGTAATT TTGAGTGTGG AAATCCAGAG 
AATCTAAAAA GCAAATGCAT TCCTGTTATG GAAGCCCAAG AATATATAGC CAATGTGACC 
AGCAGCTCCT CCGCCAAGTT TGAAGCCGCA CTGACCTGGA TACTGAGCAG TAACAAGGAC 
GTGGGCATCT GGTTGAAAGG AGAAGACCAG TCTGAATTGG TGACGACTGT GGACAAGGTG 
GTCTGCCTGG AATCTGCCCA CCCCCGCATG GGTGTTGGCT GCCGCCTGAG CCGGGCCTTG 
CTCACTGCTG TCACCAACGT GCTCATCTTC TTCTGGTGCT TGGCTTTTTT GTGGGGGCTC 
CTAATTCTCC TAAAATATCG GTGGCGAAAG TTAGAAGAGG AGGAACAAGC CATGTATGAG 
ATGGTGAAGA AGATTATAGA CGTGGTCCAG GACCATTACG TGGACTGGGA GCAGGACATG 
GAGCGCTATC CATATGTAGG CATCCTGCAC GTGCGCGACA GCTTGATCCC TCCACAGAGC 
CGGAGGCGCA TGAAGCGTGT CTGGGACCGA GCTGTGGAGT TCCTGGCCTC CAACGAATCC 
CGGATCCAGA CGGAGTCCCA CCGCGTTGCA GGAGAGGACA TGCTGGTGTG GAGATGGACT 
AAGCCCTCTT CCTTCTCTGA CTCAGAGCGA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001335639.1
CDS	15..1127
Translation	MAGLSDLELRRELQALGFQPGPITDTTRDVYRNKLRRLRGEARLRDEERLREEARPRGEERLREEARLREDAPLRARPAAASPRAEPWLSQPASGSAYATPGAYGDIRPSAASWLLPVDCERKTDEFCQAKQKAALLELLHELYNFLAIQAGNFECGNPENLKSKCIPVMEAQEYIANVTSSSSAKFEAALTWILSSNKDVGIWLKGEDQSELVTTVDKVVCLESAHPRMGVGCRLSRALLTAVTNVLIFFWCLAFLWGLLILLKYRWRKLEEEEQAMYEMVKKIIDVVQDHYVDWEQDMERYPYVGILHVRDSLIPPQSRRRMKRVWDRAVEFLASNESRIQTESHRVAGEDMLVWRWTKPSSFSDSER

Target ORF information:

RefSeq Version	NM_001348710.2
Organism	Homo sapiens(human)
Definition	Homo sapiens LEM domain nuclear envelope protein 2 (LEMD2), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001348710.2

ORF Insert Sequence:

ATGGCCGGCC TGTCGGACCT GGAACTGCGG CGGGAGCTGC AGGCCCTGGG CTTCCAGCCA 
GGACCCATCA CCGACACCAC CCGGGATGTC TACCGCAACA AGCTGCGCCG CCTGCGGGGC 
GAGGCCCGGC TGCGCGACGA GGAGCGGCTG CGGGAGGAGG CCCGGCCGCG GGGCGAGGAG 
CGGTTACGGG AAGAGGCCCG GTTACGCGAG GATGCGCCGC TGCGCGCCCG GCCCGCCGCG 
GCCTCTCCGC GGGCGGAGCC CTGGCTCTCC CAGCCGGCCT CGGGCTCGGC CTACGCGACC 
CCTGGGGCCT ACGGTGATAT CCGGCCCTCC GCGGCTTCCT GGTTATTGCC AGTGGACTGT 
GAGAGAAAAA CAGATGAGTT CTGTCAGGCC AAGCAGAAGG CAGCCTTGCT GGAGCTGCTG 
CATGAACTCT ACAATTTCCT GGCCATCCAA GCTGGTAATT TTGAGTGTGG AAATCCAGAG 
AATCTAAAAA GCAAATGCAT TCCTGTTATG GAAGCCCAAG AATATATAGC CAATGTGACC 
AGCAGCTCCT CCGCCAAGTT TGAAGCCGCA CTGACCTGGA TACTGAGCAG TAACAAGGAC 
GTGGGCATCT GGTTGAAAGG AGAAGACCAG TCTGAATTGG TGACGACTGT GGACAAGGTG 
GTCTGCCTGG AATCTGCCCA CCCCCGCATG GGTGTTGGCT GCCGCCTGAG CCGGGCCTTG 
CTCACTGCTG TCACCAACGT GCTCATCTTC TTCTGGTGCT TGGCTTTTTT GTGGGGGCTC 
CTAATTCTCC TAAAATATCG GTGGCGAAAG TTAGAAGAGG AGGAACAAGC CATGTATGAG 
ATGGTGAAGA AGATTATAGA CGTGGTCCAG GACCATTACG TGGACTGGGA GCAGGACATG 
GAGCGCTATC CATATGTAGG CATCCTGCAC GTGCGCGACA GCTTGATCCC TCCACAGAGC 
CGGAGGCGCA TGAAGCGTGT CTGGGACCGA GCTGTGGAGT TCCTGGCCTC CAACGAATCC 
CGGATCCAGA CGGAGTCCCA CCGCGTTGCA GGAGAGGACA TGCTGGTGTG GAGATGGACT 
AAGCCCTCTT CCTTCTCTGA CTCAGAGCGA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LEMD2 ( NM_001348710.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001335639.1 Homo sapiens LEM domain containing 2 (LEMD2), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu101292
Clone ID Related Accession (Same CDS sequence)	NM_001348710.2 , NM_001348710.1
Accession Version	NM_001348710.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1113bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550937600000
Organism	Homo sapiens(human)
Product	LEM domain-containing protein 2 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL158049.11. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.453577.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGGCC TGTCGGACCT GGAACTGCGG CGGGAGCTGC AGGCCCTGGG CTTCCAGCCA 
GGACCCATCA CCGACACCAC CCGGGATGTC TACCGCAACA AGCTGCGCCG CCTGCGGGGC 
GAGGCCCGGC TGCGCGACGA GGAGCGGCTG CGGGAGGAGG CCCGGCCGCG GGGCGAGGAG 
CGGTTACGGG AAGAGGCCCG GTTACGCGAG GATGCGCCGC TGCGCGCCCG GCCCGCCGCG 
GCCTCTCCGC GGGCGGAGCC CTGGCTCTCC CAGCCGGCCT CGGGCTCGGC CTACGCGACC 
CCTGGGGCCT ACGGTGATAT CCGGCCCTCC GCGGCTTCCT GGTTATTGCC AGTGGACTGT 
GAGAGAAAAA CAGATGAGTT CTGTCAGGCC AAGCAGAAGG CAGCCTTGCT GGAGCTGCTG 
CATGAACTCT ACAATTTCCT GGCCATCCAA GCTGGTAATT TTGAGTGTGG AAATCCAGAG 
AATCTAAAAA GCAAATGCAT TCCTGTTATG GAAGCCCAAG AATATATAGC CAATGTGACC 
AGCAGCTCCT CCGCCAAGTT TGAAGCCGCA CTGACCTGGA TACTGAGCAG TAACAAGGAC 
GTGGGCATCT GGTTGAAAGG AGAAGACCAG TCTGAATTGG TGACGACTGT GGACAAGGTG 
GTCTGCCTGG AATCTGCCCA CCCCCGCATG GGTGTTGGCT GCCGCCTGAG CCGGGCCTTG 
CTCACTGCTG TCACCAACGT GCTCATCTTC TTCTGGTGCT TGGCTTTTTT GTGGGGGCTC 
CTAATTCTCC TAAAATATCG GTGGCGAAAG TTAGAAGAGG AGGAACAAGC CATGTATGAG 
ATGGTGAAGA AGATTATAGA CGTGGTCCAG GACCATTACG TGGACTGGGA GCAGGACATG 
GAGCGCTATC CATATGTAGG CATCCTGCAC GTGCGCGACA GCTTGATCCC TCCACAGAGC 
CGGAGGCGCA TGAAGCGTGT CTGGGACCGA GCTGTGGAGT TCCTGGCCTC CAACGAATCC 
CGGATCCAGA CGGAGTCCCA CCGCGTTGCA GGAGAGGACA TGCTGGTGTG GAGATGGACT 
AAGCCCTCTT CCTTCTCTGA CTCAGAGCGA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001335639.1
CDS	14..1126
Translation	MAGLSDLELRRELQALGFQPGPITDTTRDVYRNKLRRLRGEARLRDEERLREEARPRGEERLREEARLREDAPLRARPAAASPRAEPWLSQPASGSAYATPGAYGDIRPSAASWLLPVDCERKTDEFCQAKQKAALLELLHELYNFLAIQAGNFECGNPENLKSKCIPVMEAQEYIANVTSSSSAKFEAALTWILSSNKDVGIWLKGEDQSELVTTVDKVVCLESAHPRMGVGCRLSRALLTAVTNVLIFFWCLAFLWGLLILLKYRWRKLEEEEQAMYEMVKKIIDVVQDHYVDWEQDMERYPYVGILHVRDSLIPPQSRRRMKRVWDRAVEFLASNESRIQTESHRVAGEDMLVWRWTKPSSFSDSER

Target ORF information:

RefSeq Version	NM_001348710.1
Organism	Homo sapiens(human)
Definition	Homo sapiens LEM domain containing 2 (LEMD2), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001348710.1

ORF Insert Sequence:

ATGGCCGGCC TGTCGGACCT GGAACTGCGG CGGGAGCTGC AGGCCCTGGG CTTCCAGCCA 
GGACCCATCA CCGACACCAC CCGGGATGTC TACCGCAACA AGCTGCGCCG CCTGCGGGGC 
GAGGCCCGGC TGCGCGACGA GGAGCGGCTG CGGGAGGAGG CCCGGCCGCG GGGCGAGGAG 
CGGTTACGGG AAGAGGCCCG GTTACGCGAG GATGCGCCGC TGCGCGCCCG GCCCGCCGCG 
GCCTCTCCGC GGGCGGAGCC CTGGCTCTCC CAGCCGGCCT CGGGCTCGGC CTACGCGACC 
CCTGGGGCCT ACGGTGATAT CCGGCCCTCC GCGGCTTCCT GGTTATTGCC AGTGGACTGT 
GAGAGAAAAA CAGATGAGTT CTGTCAGGCC AAGCAGAAGG CAGCCTTGCT GGAGCTGCTG 
CATGAACTCT ACAATTTCCT GGCCATCCAA GCTGGTAATT TTGAGTGTGG AAATCCAGAG 
AATCTAAAAA GCAAATGCAT TCCTGTTATG GAAGCCCAAG AATATATAGC CAATGTGACC 
AGCAGCTCCT CCGCCAAGTT TGAAGCCGCA CTGACCTGGA TACTGAGCAG TAACAAGGAC 
GTGGGCATCT GGTTGAAAGG AGAAGACCAG TCTGAATTGG TGACGACTGT GGACAAGGTG 
GTCTGCCTGG AATCTGCCCA CCCCCGCATG GGTGTTGGCT GCCGCCTGAG CCGGGCCTTG 
CTCACTGCTG TCACCAACGT GCTCATCTTC TTCTGGTGCT TGGCTTTTTT GTGGGGGCTC 
CTAATTCTCC TAAAATATCG GTGGCGAAAG TTAGAAGAGG AGGAACAAGC CATGTATGAG 
ATGGTGAAGA AGATTATAGA CGTGGTCCAG GACCATTACG TGGACTGGGA GCAGGACATG 
GAGCGCTATC CATATGTAGG CATCCTGCAC GTGCGCGACA GCTTGATCCC TCCACAGAGC 
CGGAGGCGCA TGAAGCGTGT CTGGGACCGA GCTGTGGAGT TCCTGGCCTC CAACGAATCC 
CGGATCCAGA CGGAGTCCCA CCGCGTTGCA GGAGAGGACA TGCTGGTGTG GAGATGGACT 
AAGCCCTCTT CCTTCTCTGA CTCAGAGCGA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LEMD2 ( XM_017010437.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016865926.1 Homo sapiens LEM domain nuclear envelope protein 2 (LEMD2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu96392
Clone ID Related Accession (Same CDS sequence)	XM_017010437.1
Accession Version	XM_017010437.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	LEM domain-containing protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCTC TAAGAGCCAC GTCAGACCGC CTCATCATGG CCGACCAAAG GCCAAGTGCA 
GACCTTCCCA ACATGGCGAC CGACCTTCCC ATCATGGCGC GTGGCCCCGC CCGCTCCGCC 
GCGCCTGCGG GAGGGAGCAG TTCCGGGTGC GGTGCGCGCC AGGGGCGGGC GGGGGGCGGC 
GTCCTGGCCA TGGCCGGCCT GTCGGACCTG GAACTGCGGC GGGAGCTGCA GGCCCTGGGC 
TTCCAGCCAG GACCCATCAC CGACACCACC CGGGATGTCT ACCGCAACAA GCTGCGCCGC 
CTGCGGGGCG AGGCCCGGCT GCGCGACGAG GAGCGGCTGC GGGAGGAGGC CCGGCCGCGG 
GGCGAGGAGC GGTTACGGGA AGAGGCCCGG TTACGCGAGG ATGCGCCGCT GCGCGCCCGG 
CCCGCCGCGG CCTCTCCGCG GGCGGAGCCC TGGCTCTCCC AGCCGGCCTC GGGCTCGGCC 
TACGCGACCC CTGGGGCCTA CGGTGATATC CGGCCCTCCG CGGCTTCCTG GGTAGGGAGC 
CGCGGCCTCG CCTATCCTGC CCGCCCGGCG CAACTCAGGC GCCGCGCCTC GGTCCGGGGC 
AGCTCCGAGG AGGACGAGGA CGCCCGGACG CCCGACAGGG CCACGCAGGG CCCGGGTCTC 
GCGGCCCGCC GCTGGTGGGC AGCGTCTCCC GCCCCGGCGC GGCTGCCTTC CTCCCTCCTC 
GGTCCCGACC CGCGCCCGGG CCTGCGGGCG ACTCGAGCGG GCCCTGCTGG CGCGGCGAGG 
GCCCGGCCTG AGGTGGGGCG CCGGCTGGAG CGCTGGCTCT CTCGGCTTCT GCTCTGGGCC 
AGCCTAGGGC TACTGCTCGT CTTCCTGGGC ATCCTTTGGG TGAAGATGGG CAAGCCCTCA 
GCGCCGCAGG AGGCGGAGGA CAACATGAAG TTATTGCCAG TGGACTGTGA GAGAAAAACA 
GATGAGTATT TGACAGTGTG GCTGGAGAAG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016865926.1
CDS	4970..5962
Translation	MAALRATSDRLIMADQRPSADLPNMATDLPIMARGPARSAAPAGGSSSGCGARQGRAGGGVLAMAGLSDLELRRELQALGFQPGPITDTTRDVYRNKLRRLRGEARLRDEERLREEARPRGEERLREEARLREDAPLRARPAAASPRAEPWLSQPASGSAYATPGAYGDIRPSAASWVGSRGLAYPARPAQLRRRASVRGSSEEDEDARTPDRATQGPGLAARRWWAASPAPARLPSSLLGPDPRPGLRATRAGPAGAARARPEVGRRLERWLSRLLLWASLGLLLVFLGILWVKMGKPSAPQEAEDNMKLLPVDCERKTDEYLTVWLEK

Target ORF information:

RefSeq Version	XM_017010437.1
Organism	Homo sapiens(human)
Definition	Homo sapiens LEM domain nuclear envelope protein 2 (LEMD2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017010437.1

ORF Insert Sequence:

ATGGCGGCTC TAAGAGCCAC GTCAGACCGC CTCATCATGG CCGACCAAAG GCCAAGTGCA 
GACCTTCCCA ACATGGCGAC CGACCTTCCC ATCATGGCGC GTGGCCCCGC CCGCTCCGCC 
GCGCCTGCGG GAGGGAGCAG TTCCGGGTGC GGTGCGCGCC AGGGGCGGGC GGGGGGCGGC 
GTCCTGGCCA TGGCCGGCCT GTCGGACCTG GAACTGCGGC GGGAGCTGCA GGCCCTGGGC 
TTCCAGCCAG GACCCATCAC CGACACCACC CGGGATGTCT ACCGCAACAA GCTGCGCCGC 
CTGCGGGGCG AGGCCCGGCT GCGCGACGAG GAGCGGCTGC GGGAGGAGGC CCGGCCGCGG 
GGCGAGGAGC GGTTACGGGA AGAGGCCCGG TTACGCGAGG ATGCGCCGCT GCGCGCCCGG 
CCCGCCGCGG CCTCTCCGCG GGCGGAGCCC TGGCTCTCCC AGCCGGCCTC GGGCTCGGCC 
TACGCGACCC CTGGGGCCTA CGGTGATATC CGGCCCTCCG CGGCTTCCTG GGTAGGGAGC 
CGCGGCCTCG CCTATCCTGC CCGCCCGGCG CAACTCAGGC GCCGCGCCTC GGTCCGGGGC 
AGCTCCGAGG AGGACGAGGA CGCCCGGACG CCCGACAGGG CCACGCAGGG CCCGGGTCTC 
GCGGCCCGCC GCTGGTGGGC AGCGTCTCCC GCCCCGGCGC GGCTGCCTTC CTCCCTCCTC 
GGTCCCGACC CGCGCCCGGG CCTGCGGGCG ACTCGAGCGG GCCCTGCTGG CGCGGCGAGG 
GCCCGGCCTG AGGTGGGGCG CCGGCTGGAG CGCTGGCTCT CTCGGCTTCT GCTCTGGGCC 
AGCCTAGGGC TACTGCTCGT CTTCCTGGGC ATCCTTTGGG TGAAGATGGG CAAGCCCTCA 
GCGCCGCAGG AGGCGGAGGA CAACATGAAG TTATTGCCAG TGGACTGTGA GAGAAAAACA 
GATGAGTATT TGACAGTGTG GCTGGAGAAG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LEMD2 ( NM_181336.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_851853.1 Homo sapiens LEM domain containing 2 (LEMD2), transcript variant 1, mRNA.

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CloneID	OHu09042
Clone ID Related Accession (Same CDS sequence)	NM_181336.3 , NM_181336.4
Accession Version	NM_181336.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1512bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506787200000
Organism	Homo sapiens(human)
Product	LEM domain-containing protein 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC039864.1, AK024858.1 and BM978238.1. This sequence is a reference standard in the RefSeqGene project. On Jan 23, 2009 this sequence version replaced NM_181336.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC051803.1, AK074959.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGGCC TGTCGGACCT GGAACTGCGG CGGGAGCTGC AGGCCCTGGG CTTCCAGCCA 
GGACCCATCA CCGACACCAC CCGGGATGTC TACCGCAACA AGCTGCGCCG CCTGCGGGGC 
GAGGCCCGGC TGCGCGACGA GGAGCGGCTG CGGGAGGAGG CCCGGCCGCG GGGCGAGGAG 
CGGTTACGGG AAGAGGCCCG GTTACGCGAG GATGCGCCGC TGCGCGCCCG GCCCGCCGCG 
GCCTCTCCGC GGGCGGAGCC CTGGCTCTCC CAGCCGGCCT CGGGCTCGGC CTACGCGACC 
CCTGGGGCCT ACGGTGATAT CCGGCCCTCC GCGGCTTCCT GGGTAGGGAG CCGCGGCCTC 
GCCTATCCTG CCCGCCCGGC GCAACTCAGG CGCCGCGCCT CGGTCCGGGG CAGCTCCGAG 
GAGGACGAGG ACGCCCGGAC GCCCGACAGG GCCACGCAGG GCCCGGGTCT CGCGGCCCGC 
CGCTGGTGGG CAGCGTCTCC CGCCCCGGCG CGGCTGCCTT CCTCCCTCCT CGGTCCCGAC 
CCGCGCCCGG GCCTGCGGGC GACTCGAGCG GGCCCTGCTG GCGCGGCGAG GGCCCGGCCT 
GAGGTGGGGC GCCGGCTGGA GCGCTGGCTC TCTCGGCTTC TGCTCTGGGC CAGCCTAGGG 
CTACTGCTCG TCTTCCTGGG CATCCTTTGG GTGAAGATGG GCAAGCCCTC AGCGCCGCAG 
GAGGCGGAGG ACAACATGAA GTTATTGCCA GTGGACTGTG AGAGAAAAAC AGATGAGTTC 
TGTCAGGCCA AGCAGAAGGC AGCCTTGCTG GAGCTGCTGC ATGAACTCTA CAATTTCCTG 
GCCATCCAAG CTGGTAATTT TGAGTGTGGA AATCCAGAGA ATCTAAAAAG CAAATGCATT 
CCTGTTATGG AAGCCCAAGA ATATATAGCC AATGTGACCA GCAGCTCCTC CGCCAAGTTT 
GAAGCCGCAC TGACCTGGAT ACTGAGCAGT AACAAGGACG TGGGCATCTG GTTGAAAGGA 
GAAGACCAGT CTGAATTGGT GACGACTGTG GACAAGGTGG TCTGCCTGGA ATCTGCCCAC 
CCCCGCATGG GTGTTGGCTG CCGCCTGAGC CGGGCCTTGC TCACTGCTGT CACCAACGTG 
CTCATCTTCT TCTGGTGCTT GGCTTTTTTG TGGGGGCTCC TAATTCTCCT AAAATATCGG 
TGGCGAAAGT TAGAAGAGGA GGAACAAGCC ATGTATGAGA TGGTGAAGAA GATTATAGAC 
GTGGTCCAGG ACCATTACGT GGACTGGGAG CAGGACATGG AGCGCTATCC ATATGTAGGC 
ATCCTGCACG TGCGCGACAG CTTGATCCCT CCACAGAGCC GGAGGCGCAT GAAGCGTGTC 
TGGGACCGAG CTGTGGAGTT CCTGGCCTCC AACGAATCCC GGATCCAGAC GGAGTCCCAC 
CGCGTTGCAG GAGAGGACAT GCTGGTGTGG AGATGGACTA AGCCCTCTTC CTTCTCTGAC 
TCAGAGCGAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_851853.1
CDS	14..1525
Translation	MAGLSDLELRRELQALGFQPGPITDTTRDVYRNKLRRLRGEARLRDEERLREEARPRGEERLREEARLREDAPLRARPAAASPRAEPWLSQPASGSAYATPGAYGDIRPSAASWVGSRGLAYPARPAQLRRRASVRGSSEEDEDARTPDRATQGPGLAARRWWAASPAPARLPSSLLGPDPRPGLRATRAGPAGAARARPEVGRRLERWLSRLLLWASLGLLLVFLGILWVKMGKPSAPQEAEDNMKLLPVDCERKTDEFCQAKQKAALLELLHELYNFLAIQAGNFECGNPENLKSKCIPVMEAQEYIANVTSSSSAKFEAALTWILSSNKDVGIWLKGEDQSELVTTVDKVVCLESAHPRMGVGCRLSRALLTAVTNVLIFFWCLAFLWGLLILLKYRWRKLEEEEQAMYEMVKKIIDVVQDHYVDWEQDMERYPYVGILHVRDSLIPPQSRRRMKRVWDRAVEFLASNESRIQTESHRVAGEDMLVWRWTKPSSFSDSER

Target ORF information:

RefSeq Version	NM_181336.3
Organism	Homo sapiens(human)
Definition	Homo sapiens LEM domain containing 2 (LEMD2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181336.3

ORF Insert Sequence:

ATGGCCGGCC TGTCGGACCT GGAACTGCGG CGGGAGCTGC AGGCCCTGGG CTTCCAGCCA 
GGACCCATCA CCGACACCAC CCGGGATGTC TACCGCAACA AGCTGCGCCG CCTGCGGGGC 
GAGGCCCGGC TGCGCGACGA GGAGCGGCTG CGGGAGGAGG CCCGGCCGCG GGGCGAGGAG 
CGGTTACGGG AAGAGGCCCG GTTACGCGAG GATGCGCCGC TGCGCGCCCG GCCCGCCGCG 
GCCTCTCCGC GGGCGGAGCC CTGGCTCTCC CAGCCGGCCT CGGGCTCGGC CTACGCGACC 
CCTGGGGCCT ACGGTGATAT CCGGCCCTCC GCGGCTTCCT GGGTAGGGAG CCGCGGCCTC 
GCCTATCCTG CCCGCCCGGC GCAACTCAGG CGCCGCGCCT CGGTCCGGGG CAGCTCCGAG 
GAGGACGAGG ACGCCCGGAC GCCCGACAGG GCCACGCAGG GCCCGGGTCT CGCGGCCCGC 
CGCTGGTGGG CAGCGTCTCC CGCCCCGGCG CGGCTGCCTT CCTCCCTCCT CGGTCCCGAC 
CCGCGCCCGG GCCTGCGGGC GACTCGAGCG GGCCCTGCTG GCGCGGCGAG GGCCCGGCCT 
GAGGTGGGGC GCCGGCTGGA GCGCTGGCTC TCTCGGCTTC TGCTCTGGGC CAGCCTAGGG 
CTACTGCTCG TCTTCCTGGG CATCCTTTGG GTGAAGATGG GCAAGCCCTC AGCGCCGCAG 
GAGGCGGAGG ACAACATGAA GTTATTGCCA GTGGACTGTG AGAGAAAAAC AGATGAGTTC 
TGTCAGGCCA AGCAGAAGGC AGCCTTGCTG GAGCTGCTGC ATGAACTCTA CAATTTCCTG 
GCCATCCAAG CTGGTAATTT TGAGTGTGGA AATCCAGAGA ATCTAAAAAG CAAATGCATT 
CCTGTTATGG AAGCCCAAGA ATATATAGCC AATGTGACCA GCAGCTCCTC CGCCAAGTTT 
GAAGCCGCAC TGACCTGGAT ACTGAGCAGT AACAAGGACG TGGGCATCTG GTTGAAAGGA 
GAAGACCAGT CTGAATTGGT GACGACTGTG GACAAGGTGG TCTGCCTGGA ATCTGCCCAC 
CCCCGCATGG GTGTTGGCTG CCGCCTGAGC CGGGCCTTGC TCACTGCTGT CACCAACGTG 
CTCATCTTCT TCTGGTGCTT GGCTTTTTTG TGGGGGCTCC TAATTCTCCT AAAATATCGG 
TGGCGAAAGT TAGAAGAGGA GGAACAAGCC ATGTATGAGA TGGTGAAGAA GATTATAGAC 
GTGGTCCAGG ACCATTACGT GGACTGGGAG CAGGACATGG AGCGCTATCC ATATGTAGGC 
ATCCTGCACG TGCGCGACAG CTTGATCCCT CCACAGAGCC GGAGGCGCAT GAAGCGTGTC 
TGGGACCGAG CTGTGGAGTT CCTGGCCTCC AACGAATCCC GGATCCAGAC GGAGTCCCAC 
CGCGTTGCAG GAGAGGACAT GCTGGTGTGG AGATGGACTA AGCCCTCTTC CTTCTCTGAC 
TCAGAGCGAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LEMD2 ( NM_181336.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_851853.1 Homo sapiens LEM domain nuclear envelope protein 2 (LEMD2), transcript variant 1, mRNA.

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CloneID	OHu09042
Clone ID Related Accession (Same CDS sequence)	NM_181336.3 , NM_181336.4
Accession Version	NM_181336.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1512bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577808000000
Organism	Homo sapiens(human)
Product	LEM domain-containing protein 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL158049.11, BC039864.1, AK024858.1 and BM978238.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_181336.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC051803.1, AK074959.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000293760.10/ ENSP00000293760.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGGCC TGTCGGACCT GGAACTGCGG CGGGAGCTGC AGGCCCTGGG CTTCCAGCCA 
GGACCCATCA CCGACACCAC CCGGGATGTC TACCGCAACA AGCTGCGCCG CCTGCGGGGC 
GAGGCCCGGC TGCGCGACGA GGAGCGGCTG CGGGAGGAGG CCCGGCCGCG GGGCGAGGAG 
CGGTTACGGG AAGAGGCCCG GTTACGCGAG GATGCGCCGC TGCGCGCCCG GCCCGCCGCG 
GCCTCTCCGC GGGCGGAGCC CTGGCTCTCC CAGCCGGCCT CGGGCTCGGC CTACGCGACC 
CCTGGGGCCT ACGGTGATAT CCGGCCCTCC GCGGCTTCCT GGGTAGGGAG CCGCGGCCTC 
GCCTATCCTG CCCGCCCGGC GCAACTCAGG CGCCGCGCCT CGGTCCGGGG CAGCTCCGAG 
GAGGACGAGG ACGCCCGGAC GCCCGACAGG GCCACGCAGG GCCCGGGTCT CGCGGCCCGC 
CGCTGGTGGG CAGCGTCTCC CGCCCCGGCG CGGCTGCCTT CCTCCCTCCT CGGTCCCGAC 
CCGCGCCCGG GCCTGCGGGC GACTCGAGCG GGCCCTGCTG GCGCGGCGAG GGCCCGGCCT 
GAGGTGGGGC GCCGGCTGGA GCGCTGGCTC TCTCGGCTTC TGCTCTGGGC CAGCCTAGGG 
CTACTGCTCG TCTTCCTGGG CATCCTTTGG GTGAAGATGG GCAAGCCCTC AGCGCCGCAG 
GAGGCGGAGG ACAACATGAA GTTATTGCCA GTGGACTGTG AGAGAAAAAC AGATGAGTTC 
TGTCAGGCCA AGCAGAAGGC AGCCTTGCTG GAGCTGCTGC ATGAACTCTA CAATTTCCTG 
GCCATCCAAG CTGGTAATTT TGAGTGTGGA AATCCAGAGA ATCTAAAAAG CAAATGCATT 
CCTGTTATGG AAGCCCAAGA ATATATAGCC AATGTGACCA GCAGCTCCTC CGCCAAGTTT 
GAAGCCGCAC TGACCTGGAT ACTGAGCAGT AACAAGGACG TGGGCATCTG GTTGAAAGGA 
GAAGACCAGT CTGAATTGGT GACGACTGTG GACAAGGTGG TCTGCCTGGA ATCTGCCCAC 
CCCCGCATGG GTGTTGGCTG CCGCCTGAGC CGGGCCTTGC TCACTGCTGT CACCAACGTG 
CTCATCTTCT TCTGGTGCTT GGCTTTTTTG TGGGGGCTCC TAATTCTCCT AAAATATCGG 
TGGCGAAAGT TAGAAGAGGA GGAACAAGCC ATGTATGAGA TGGTGAAGAA GATTATAGAC 
GTGGTCCAGG ACCATTACGT GGACTGGGAG CAGGACATGG AGCGCTATCC ATATGTAGGC 
ATCCTGCACG TGCGCGACAG CTTGATCCCT CCACAGAGCC GGAGGCGCAT GAAGCGTGTC 
TGGGACCGAG CTGTGGAGTT CCTGGCCTCC AACGAATCCC GGATCCAGAC GGAGTCCCAC 
CGCGTTGCAG GAGAGGACAT GCTGGTGTGG AGATGGACTA AGCCCTCTTC CTTCTCTGAC 
TCAGAGCGAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_851853.1
CDS	15..1526
Translation	MAGLSDLELRRELQALGFQPGPITDTTRDVYRNKLRRLRGEARLRDEERLREEARPRGEERLREEARLREDAPLRARPAAASPRAEPWLSQPASGSAYATPGAYGDIRPSAASWVGSRGLAYPARPAQLRRRASVRGSSEEDEDARTPDRATQGPGLAARRWWAASPAPARLPSSLLGPDPRPGLRATRAGPAGAARARPEVGRRLERWLSRLLLWASLGLLLVFLGILWVKMGKPSAPQEAEDNMKLLPVDCERKTDEFCQAKQKAALLELLHELYNFLAIQAGNFECGNPENLKSKCIPVMEAQEYIANVTSSSSAKFEAALTWILSSNKDVGIWLKGEDQSELVTTVDKVVCLESAHPRMGVGCRLSRALLTAVTNVLIFFWCLAFLWGLLILLKYRWRKLEEEEQAMYEMVKKIIDVVQDHYVDWEQDMERYPYVGILHVRDSLIPPQSRRRMKRVWDRAVEFLASNESRIQTESHRVAGEDMLVWRWTKPSSFSDSER

Target ORF information:

RefSeq Version	NM_181336.4
Organism	Homo sapiens(human)
Definition	Homo sapiens LEM domain nuclear envelope protein 2 (LEMD2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181336.4

ORF Insert Sequence:

ATGGCCGGCC TGTCGGACCT GGAACTGCGG CGGGAGCTGC AGGCCCTGGG CTTCCAGCCA 
GGACCCATCA CCGACACCAC CCGGGATGTC TACCGCAACA AGCTGCGCCG CCTGCGGGGC 
GAGGCCCGGC TGCGCGACGA GGAGCGGCTG CGGGAGGAGG CCCGGCCGCG GGGCGAGGAG 
CGGTTACGGG AAGAGGCCCG GTTACGCGAG GATGCGCCGC TGCGCGCCCG GCCCGCCGCG 
GCCTCTCCGC GGGCGGAGCC CTGGCTCTCC CAGCCGGCCT CGGGCTCGGC CTACGCGACC 
CCTGGGGCCT ACGGTGATAT CCGGCCCTCC GCGGCTTCCT GGGTAGGGAG CCGCGGCCTC 
GCCTATCCTG CCCGCCCGGC GCAACTCAGG CGCCGCGCCT CGGTCCGGGG CAGCTCCGAG 
GAGGACGAGG ACGCCCGGAC GCCCGACAGG GCCACGCAGG GCCCGGGTCT CGCGGCCCGC 
CGCTGGTGGG CAGCGTCTCC CGCCCCGGCG CGGCTGCCTT CCTCCCTCCT CGGTCCCGAC 
CCGCGCCCGG GCCTGCGGGC GACTCGAGCG GGCCCTGCTG GCGCGGCGAG GGCCCGGCCT 
GAGGTGGGGC GCCGGCTGGA GCGCTGGCTC TCTCGGCTTC TGCTCTGGGC CAGCCTAGGG 
CTACTGCTCG TCTTCCTGGG CATCCTTTGG GTGAAGATGG GCAAGCCCTC AGCGCCGCAG 
GAGGCGGAGG ACAACATGAA GTTATTGCCA GTGGACTGTG AGAGAAAAAC AGATGAGTTC 
TGTCAGGCCA AGCAGAAGGC AGCCTTGCTG GAGCTGCTGC ATGAACTCTA CAATTTCCTG 
GCCATCCAAG CTGGTAATTT TGAGTGTGGA AATCCAGAGA ATCTAAAAAG CAAATGCATT 
CCTGTTATGG AAGCCCAAGA ATATATAGCC AATGTGACCA GCAGCTCCTC CGCCAAGTTT 
GAAGCCGCAC TGACCTGGAT ACTGAGCAGT AACAAGGACG TGGGCATCTG GTTGAAAGGA 
GAAGACCAGT CTGAATTGGT GACGACTGTG GACAAGGTGG TCTGCCTGGA ATCTGCCCAC 
CCCCGCATGG GTGTTGGCTG CCGCCTGAGC CGGGCCTTGC TCACTGCTGT CACCAACGTG 
CTCATCTTCT TCTGGTGCTT GGCTTTTTTG TGGGGGCTCC TAATTCTCCT AAAATATCGG 
TGGCGAAAGT TAGAAGAGGA GGAACAAGCC ATGTATGAGA TGGTGAAGAA GATTATAGAC 
GTGGTCCAGG ACCATTACGT GGACTGGGAG CAGGACATGG AGCGCTATCC ATATGTAGGC 
ATCCTGCACG TGCGCGACAG CTTGATCCCT CCACAGAGCC GGAGGCGCAT GAAGCGTGTC 
TGGGACCGAG CTGTGGAGTT CCTGGCCTCC AACGAATCCC GGATCCAGAC GGAGTCCCAC 
CGCGTTGCAG GAGAGGACAT GCTGGTGTGG AGATGGACTA AGCCCTCTTC CTTCTCTGAC 
TCAGAGCGAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LEMD2 ( NM_001348709.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001335638.1 Homo sapiens LEM domain nuclear envelope protein 2 (LEMD2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu09185
Clone ID Related Accession (Same CDS sequence)	NM_001348709.2 , NM_001348709.1 , NM_001143944.1
Accession Version	NM_001348709.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 606bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577721600000
Organism	Homo sapiens(human)
Product	LEM domain-containing protein 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL158049.11. On May 31, 2019 this sequence version replaced NM_001348709.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.66885.1, SRR1803617.282008.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAGCCC AAGAATATAT AGCCAATGTG ACCAGCAGCT CCTCCGCCAA GTTTGAAGCC 
GCACTGACCT GGATACTGAG CAGTAACAAG GACGTGGGCA TCTGGTTGAA AGGAGAAGAC 
CAGTCTGAAT TGGTGACGAC TGTGGACAAG GTGGTCTGCC TGGAATCTGC CCACCCCCGC 
ATGGGTGTTG GCTGCCGCCT GAGCCGGGCC TTGCTCACTG CTGTCACCAA CGTGCTCATC 
TTCTTCTGGT GCTTGGCTTT TTTGTGGGGG CTCCTAATTC TCCTAAAATA TCGGTGGCGA 
AAGTTAGAAG AGGAGGAACA AGCCATGTAT GAGATGGTGA AGAAGATTAT AGACGTGGTC 
CAGGACCATT ACGTGGACTG GGAGCAGGAC ATGGAGCGCT ATCCATATGT AGGCATCCTG 
CACGTGCGCG ACAGCTTGAT CCCTCCACAG AGCCGGAGGC GCATGAAGCG TGTCTGGGAC 
CGAGCTGTGG AGTTCCTGGC CTCCAACGAA TCCCGGATCC AGACGGAGTC CCACCGCGTT 
GCAGGAGAGG ACATGCTGGT GTGGAGATGG ACTAAGCCCT CTTCCTTCTC TGACTCAGAG 
CGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001335638.1
CDS	527..1132
Translation	MEAQEYIANVTSSSSAKFEAALTWILSSNKDVGIWLKGEDQSELVTTVDKVVCLESAHPRMGVGCRLSRALLTAVTNVLIFFWCLAFLWGLLILLKYRWRKLEEEEQAMYEMVKKIIDVVQDHYVDWEQDMERYPYVGILHVRDSLIPPQSRRRMKRVWDRAVEFLASNESRIQTESHRVAGEDMLVWRWTKPSSFSDSER

Target ORF information:

RefSeq Version	NM_001348709.2
Organism	Homo sapiens(human)
Definition	Homo sapiens LEM domain nuclear envelope protein 2 (LEMD2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001348709.2

ORF Insert Sequence:

ATGGAAGCCC AAGAATATAT AGCCAATGTG ACCAGCAGCT CCTCCGCCAA GTTTGAAGCC 
GCACTGACCT GGATACTGAG CAGTAACAAG GACGTGGGCA TCTGGTTGAA AGGAGAAGAC 
CAGTCTGAAT TGGTGACGAC TGTGGACAAG GTGGTCTGCC TGGAATCTGC CCACCCCCGC 
ATGGGTGTTG GCTGCCGCCT GAGCCGGGCC TTGCTCACTG CTGTCACCAA CGTGCTCATC 
TTCTTCTGGT GCTTGGCTTT TTTGTGGGGG CTCCTAATTC TCCTAAAATA TCGGTGGCGA 
AAGTTAGAAG AGGAGGAACA AGCCATGTAT GAGATGGTGA AGAAGATTAT AGACGTGGTC 
CAGGACCATT ACGTGGACTG GGAGCAGGAC ATGGAGCGCT ATCCATATGT AGGCATCCTG 
CACGTGCGCG ACAGCTTGAT CCCTCCACAG AGCCGGAGGC GCATGAAGCG TGTCTGGGAC 
CGAGCTGTGG AGTTCCTGGC CTCCAACGAA TCCCGGATCC AGACGGAGTC CCACCGCGTT 
GCAGGAGAGG ACATGCTGGT GTGGAGATGG ACTAAGCCCT CTTCCTTCTC TGACTCAGAG 
CGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LEMD2 ( NM_001348709.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001335638.1 Homo sapiens LEM domain containing 2 (LEMD2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu09185
Clone ID Related Accession (Same CDS sequence)	NM_001348709.2 , NM_001348709.1 , NM_001143944.1
Accession Version	NM_001348709.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 606bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550937600000
Organism	Homo sapiens(human)
Product	LEM domain-containing protein 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL158049.11. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.66885.1, SRR1803617.282008.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAGCCC AAGAATATAT AGCCAATGTG ACCAGCAGCT CCTCCGCCAA GTTTGAAGCC 
GCACTGACCT GGATACTGAG CAGTAACAAG GACGTGGGCA TCTGGTTGAA AGGAGAAGAC 
CAGTCTGAAT TGGTGACGAC TGTGGACAAG GTGGTCTGCC TGGAATCTGC CCACCCCCGC 
ATGGGTGTTG GCTGCCGCCT GAGCCGGGCC TTGCTCACTG CTGTCACCAA CGTGCTCATC 
TTCTTCTGGT GCTTGGCTTT TTTGTGGGGG CTCCTAATTC TCCTAAAATA TCGGTGGCGA 
AAGTTAGAAG AGGAGGAACA AGCCATGTAT GAGATGGTGA AGAAGATTAT AGACGTGGTC 
CAGGACCATT ACGTGGACTG GGAGCAGGAC ATGGAGCGCT ATCCATATGT AGGCATCCTG 
CACGTGCGCG ACAGCTTGAT CCCTCCACAG AGCCGGAGGC GCATGAAGCG TGTCTGGGAC 
CGAGCTGTGG AGTTCCTGGC CTCCAACGAA TCCCGGATCC AGACGGAGTC CCACCGCGTT 
GCAGGAGAGG ACATGCTGGT GTGGAGATGG ACTAAGCCCT CTTCCTTCTC TGACTCAGAG 
CGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001335638.1
CDS	526..1131
Translation	MEAQEYIANVTSSSSAKFEAALTWILSSNKDVGIWLKGEDQSELVTTVDKVVCLESAHPRMGVGCRLSRALLTAVTNVLIFFWCLAFLWGLLILLKYRWRKLEEEEQAMYEMVKKIIDVVQDHYVDWEQDMERYPYVGILHVRDSLIPPQSRRRMKRVWDRAVEFLASNESRIQTESHRVAGEDMLVWRWTKPSSFSDSER

Target ORF information:

RefSeq Version	NM_001348709.1
Organism	Homo sapiens(human)
Definition	Homo sapiens LEM domain containing 2 (LEMD2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001348709.1

ORF Insert Sequence:

ATGGAAGCCC AAGAATATAT AGCCAATGTG ACCAGCAGCT CCTCCGCCAA GTTTGAAGCC 
GCACTGACCT GGATACTGAG CAGTAACAAG GACGTGGGCA TCTGGTTGAA AGGAGAAGAC 
CAGTCTGAAT TGGTGACGAC TGTGGACAAG GTGGTCTGCC TGGAATCTGC CCACCCCCGC 
ATGGGTGTTG GCTGCCGCCT GAGCCGGGCC TTGCTCACTG CTGTCACCAA CGTGCTCATC 
TTCTTCTGGT GCTTGGCTTT TTTGTGGGGG CTCCTAATTC TCCTAAAATA TCGGTGGCGA 
AAGTTAGAAG AGGAGGAACA AGCCATGTAT GAGATGGTGA AGAAGATTAT AGACGTGGTC 
CAGGACCATT ACGTGGACTG GGAGCAGGAC ATGGAGCGCT ATCCATATGT AGGCATCCTG 
CACGTGCGCG ACAGCTTGAT CCCTCCACAG AGCCGGAGGC GCATGAAGCG TGTCTGGGAC 
CGAGCTGTGG AGTTCCTGGC CTCCAACGAA TCCCGGATCC AGACGGAGTC CCACCGCGTT 
GCAGGAGAGG ACATGCTGGT GTGGAGATGG ACTAAGCCCT CTTCCTTCTC TGACTCAGAG 
CGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LEMD2 ( NM_001143944.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001137416.1 Homo sapiens LEM domain nuclear envelope protein 2 (LEMD2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09185
Clone ID Related Accession (Same CDS sequence)	NM_001348709.2 , NM_001348709.1 , NM_001143944.1
Accession Version	NM_001143944.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 606bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1570204800000
Organism	Homo sapiens(human)
Product	LEM domain-containing protein 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC340017.1, BC039864.1, AK024858.1 and BM978238.1. Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.177955.1, SRR1803617.89757.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAGCCC AAGAATATAT AGCCAATGTG ACCAGCAGCT CCTCCGCCAA GTTTGAAGCC 
GCACTGACCT GGATACTGAG CAGTAACAAG GACGTGGGCA TCTGGTTGAA AGGAGAAGAC 
CAGTCTGAAT TGGTGACGAC TGTGGACAAG GTGGTCTGCC TGGAATCTGC CCACCCCCGC 
ATGGGTGTTG GCTGCCGCCT GAGCCGGGCC TTGCTCACTG CTGTCACCAA CGTGCTCATC 
TTCTTCTGGT GCTTGGCTTT TTTGTGGGGG CTCCTAATTC TCCTAAAATA TCGGTGGCGA 
AAGTTAGAAG AGGAGGAACA AGCCATGTAT GAGATGGTGA AGAAGATTAT AGACGTGGTC 
CAGGACCATT ACGTGGACTG GGAGCAGGAC ATGGAGCGCT ATCCATATGT AGGCATCCTG 
CACGTGCGCG ACAGCTTGAT CCCTCCACAG AGCCGGAGGC GCATGAAGCG TGTCTGGGAC 
CGAGCTGTGG AGTTCCTGGC CTCCAACGAA TCCCGGATCC AGACGGAGTC CCACCGCGTT 
GCAGGAGAGG ACATGCTGGT GTGGAGATGG ACTAAGCCCT CTTCCTTCTC TGACTCAGAG 
CGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001137416.1
CDS	339..944
Translation	MEAQEYIANVTSSSSAKFEAALTWILSSNKDVGIWLKGEDQSELVTTVDKVVCLESAHPRMGVGCRLSRALLTAVTNVLIFFWCLAFLWGLLILLKYRWRKLEEEEQAMYEMVKKIIDVVQDHYVDWEQDMERYPYVGILHVRDSLIPPQSRRRMKRVWDRAVEFLASNESRIQTESHRVAGEDMLVWRWTKPSSFSDSER

Target ORF information:

RefSeq Version	NM_001143944.1
Organism	Homo sapiens(human)
Definition	Homo sapiens LEM domain nuclear envelope protein 2 (LEMD2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001143944.1

ORF Insert Sequence:

ATGGAAGCCC AAGAATATAT AGCCAATGTG ACCAGCAGCT CCTCCGCCAA GTTTGAAGCC 
GCACTGACCT GGATACTGAG CAGTAACAAG GACGTGGGCA TCTGGTTGAA AGGAGAAGAC 
CAGTCTGAAT TGGTGACGAC TGTGGACAAG GTGGTCTGCC TGGAATCTGC CCACCCCCGC 
ATGGGTGTTG GCTGCCGCCT GAGCCGGGCC TTGCTCACTG CTGTCACCAA CGTGCTCATC 
TTCTTCTGGT GCTTGGCTTT TTTGTGGGGG CTCCTAATTC TCCTAAAATA TCGGTGGCGA 
AAGTTAGAAG AGGAGGAACA AGCCATGTAT GAGATGGTGA AGAAGATTAT AGACGTGGTC 
CAGGACCATT ACGTGGACTG GGAGCAGGAC ATGGAGCGCT ATCCATATGT AGGCATCCTG 
CACGTGCGCG ACAGCTTGAT CCCTCCACAG AGCCGGAGGC GCATGAAGCG TGTCTGGGAC 
CGAGCTGTGG AGTTCCTGGC CTCCAACGAA TCCCGGATCC AGACGGAGTC CCACCGCGTT 
GCAGGAGAGG ACATGCTGGT GTGGAGATGG ACTAAGCCCT CTTCCTTCTC TGACTCAGAG 
CGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nuclear envelope localization of LEMD2 is developmentally dynamic and lamin A/C dependent yet insufficient for heterochromatin tethering.
Differentiation; research in biological diversity9458-70(2017 Mar - Apr)
Thanisch K,Song C,Engelkamp D,Koch J,Wang A,Hallberg E,Foisner R,Leonhardt H,Stewart CL,Joffe B,Solovei I

Repair of nuclear ruptures requires barrier-to-autointegration factor.
The Journal of cell biology218(7)2136-2149(2019 Jul)
Halfmann CT,Sears RM,Katiyar A,Busselman BW,Aman LK,Zhang Q,O'Bryan CS,Angelini TE,Lele TP,Roux KJ

LEM-domain proteins are lost during human spermiogenesis but BAF and BAF-L persist.
Reproduction (Cambridge, England)154(4)387-401(2017 10)
Elkhatib RA,Paci M,Boissier R,Longepied G,Auguste Y,Achard V,Bourgeois P,Levy N,Branger N,Mitchell MJ,Metzler-Guillemain C

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells.
Proceedings of the National Academy of Sciences of the United States of America114(11)E2166-E2175(2017 03)
Gu M,LaJoie D,Chen OS,von Appen A,Ladinsky MS,Redd MJ,Nikolova L,Bjorkman PJ,Sundquist WI,Ullman KS,Frost A

Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.
Gut63(1)80-7(2014 Jan)
Yang SK,Hong M,Zhao W,Jung Y,Baek J,Tayebi N,Kim KM,Ye BD,Kim KJ,Park SH,Lee I,Lee EJ,Kim WH,Cheon JH,Kim YH,Jang BI,Kim HS,Choi JH,Koo JS,Lee JH,Jung SA,Lee YJ,Jang JY,Shin HD,Kang D,Youn HS,Liu J,Song K

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LEMD2 cDNA ORF clone, Homo sapiens(human)

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