EXT1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EXT1
Entrez Gene ID	2131
Full Name	exostosin glycosyltransferase 1
Synonyms	EXT,LGCR,LGS,TRPS2,TTV
General protein information	Preferred Names exostosin glycosyltransferase 1 Names exostosin-1 Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase Langer-Giedion syndrome chromosome region N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase exostoses (multiple) 1 glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase multiple exostoses protein 1 putative tumor suppressor protein EXT1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q24.11
Summary	This gene encodes an endoplasmic reticulum-resident type II transmembrane glycosyltransferase involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type I form of multiple exostoses. [provided by RefSeq, Jul 2008].
Disorder MIM:	608177
Disorder Html:	Exostoses, multiple, type 1, 133700 (3); Chondrosarcoma, 215300 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000127.3	NP_000118.2	exostosin-1
NM_000127.2	NP_000118.2	exostosin-1

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	ext1b	NP_001012369.2
Xenopus tropicalis (tropical clawed frog)	ext1	NP_001006730.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010388	XP_311558.3
Homo sapiens (human)	EXT1	NP_000118.2
Macaca mulatta (Rhesus monkey)	EXT1	XP_001096808.1
Gallus gallus (chicken)	LOC100858205	XP_003640902.1
Canis lupus familiaris (dog)	EXT1	XP_539145.2
Bos taurus (cattle)	EXT1	NP_001091564.1
Mus musculus (house mouse)	Ext1	NP_034292.2
Rattus norvegicus (Norway rat)	Ext1	NP_001124012.1
Caenorhabditis elegans (roundworm)	rib-1	NP_502180.1
Pan troglodytes (chimpanzee)	EXT1	XP_001141496.1
Drosophila melanogaster (fruit fly)	ttv	NP_477231.1

Gene Ontology
Bibliography

Related articles in PubMed

[Analysis of EXT1 and EXT2 gene mutations in two Chinese pedigrees affected with hereditary multiple exostosis].
Bai Y, Liu N, Hu S, Wu Q, Kong X
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics36(5)451-455(2019 May)

A novel splice mutation induces exon skipping of the EXT1 gene in patients with hereditary multiple exostoses.
Guo X, Lin M, Yan W, Chen W, Hong G
International journal of oncology54(3)859-868(2019 Mar)

The role of EXT1 gene mutation and its high expression of calcitonin gene-related peptide in the development of multiple exostosis.
Wu ZY, Wang Y, Wang JW, Chen YZ, Guo Y
Biochemical and biophysical research communications505(4)959-965(2018 11)

Heterogeneous spectrum of EXT gene mutations in Chinese patients with hereditary multiple osteochondromas.
Li Y, Wang J, Tang J, Wang Z, Han B, Li N, Yu T, Chen Y, Fu Q
Medicine97(42)e12855(2018 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following EXT1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EXT1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17950	NM_000127.3 Latest version!	Homo sapiens exostosin glycosyltransferase 1 (EXT1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu17950	NM_000127.2	Homo sapiens exostosin glycosyltransferase 1 (EXT1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EXT1 ( NM_000127.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000118.2 Homo sapiens exostosin glycosyltransferase 1 (EXT1), mRNA.

Price & Availability↑

CloneID	OHu17950
Clone ID Related Accession (Same CDS sequence)	NM_000127.3 , NM_000127.2
Accession Version	NM_000127.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2241bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1576684800000
Organism	Homo sapiens(human)
Product	exostosin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP003476.2, BC001174.1 and AC113188.6. On Nov 21, 2019 this sequence version replaced NM_000127.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: S79639.1, BC001174.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGGCCA AAAAACGCTA TTTCATCCTG CTCTCAGCTG GCTCTTGTCT CGCCCTTTTG 
TTTTATTTCG GAGGCTTGCA GTTTAGGGCA TCGAGGAGCC ACAGCCGGAG AGAAGAACAC 
AGCGGTAGGA ATGGCTTGCA CCACCCCAGT CCGGATCATT TCTGGCCCCG CTTCCCGGAC 
GCTCTGCGCC CCTTCGTTCC TTGGGATCAA TTGGAAAACG AGGATTCCAG CGTGCACATT 
TCCCCCCGGC AGAAGCGAGA TGCCAACTCC AGCATCTACA AAGGCAAGAA GTGCCGCATG 
GAGTCCTGCT TCGATTTCAC CCTTTGCAAG AAAAACGGCT TCAAAGTCTA CGTATACCCA 
CAGCAAAAAG GGGAGAAAAT CGCCGAAAGT TACCAAAACA TTCTAGCGGC CATCGAGGGC 
TCCAGGTTCT ACACCTCGGA CCCCAGCCAG GCGTGCCTCT TTGTCCTGAG TCTGGATACT 
TTAGACAGAG ACCAGTTGTC ACCTCAGTAT GTGCACAATT TGAGATCCAA AGTGCAGAGT 
CTCCACTTGT GGAACAATGG TAGGAATCAT TTAATTTTTA ATTTATATTC CGGCACTTGG 
CCTGACTACA CCGAGGACGT GGGGTTTGAC ATCGGCCAGG CGATGCTGGC CAAAGCCAGC 
ATCAGTACTG AAAACTTCCG ACCCAACTTT GATGTTTCTA TTCCCCTCTT TTCTAAGGAT 
CATCCCAGGA CAGGAGGGGA GAGGGGGTTT TTGAAGTTCA ACACCATCCC TCCTCTCAGG 
AAGTACATGC TGGTATTCAA GGGGAAGAGG TACCTGACAG GGATAGGATC AGACACCAGG 
AATGCCTTAT ATCACGTCCA TAACGGGGAG GACGTTGTGC TCCTCACCAC CTGCAAGCAT 
GGCAAAGACT GGCAAAAGCA CAAGGATTCT CGCTGTGACA GAGACAACAC CGAGTATGAG 
AAGTATGATT ATCGGGAAAT GCTGCACAAT GCCACTTTCT GTCTGGTTCC TCGTGGTCGC 
AGGCTTGGGT CCTTCAGATT CCTGGAGGCT TTGCAGGCTG CCTGCGTCCC TGTGATGCTC 
AGCAATGGAT GGGAGTTGCC ATTCTCTGAA GTGATTAATT GGAACCAAGC TGCCGTCATA 
GGCGATGAGA GATTGTTATT ACAGATTCCT TCTACAATCA GGTCTATTCA TCAGGATAAA 
ATCCTAGCAC TTAGACAGCA GACACAATTC TTGTGGGAGG CTTATTTTTC TTCAGTTGAG 
AAGATTGTAT TAACTACACT AGAGATTATT CAGGACAGAA TATTCAAGCA CATATCACGT 
AACAGTTTAA TATGGAACAA ACATCCTGGA GGATTGTTCG TACTACCACA GTATTCATCT 
TATCTGGGAG ATTTTCCTTA CTACTATGCT AATTTAGGTT TAAAGCCCCC CTCCAAATTC 
ACTGCAGTCA TCCATGCGGT GACCCCCCTG GTCTCTCAGT CCCAGCCAGT GTTGAAGCTT 
CTCGTGGCTG CAGCCAAGTC CCAGTACTGT GCCCAGATCA TAGTTCTATG GAATTGTGAC 
AAGCCCCTAC CAGCCAAACA CCGCTGGCCT GCCACTGCTG TGCCTGTCGT CGTCATTGAA 
GGAGAGAGCA AGGTTATGAG CAGCCGTTTT CTGCCCTACG ACAACATCAT CACAGACGCC 
GTGCTCAGCC TTGACGAGGA CACGGTGCTT TCAACAACAG AGGTGGATTT CGCCTTCACA 
GTGTGGCAGA GCTTCCCTGA GAGGATTGTG GGGTACCCCG CGCGCAGCCA CTTCTGGGAT 
AACTCTAAGG AGCGGTGGGG ATACACATCA AAGTGGACGA ACGACTACTC CATGGTGTTG 
ACAGGAGCTG CTATTTACCA CAAATATTAT CACTACCTAT ACTCCCATTA CCTGCCAGCC 
AGCCTGAAGA ACATGGTGGA CCAATTGGCC AATTGTGAGG ACATTCTCAT GAACTTCCTG 
GTGTCTGCTG TGACAAAATT GCCTCCAATC AAAGTGACCC AGAAGAAGCA GTATAAGGAG 
ACAATGATGG GACAGACTTC TCGGGCTTCC CGTTGGGCTG ACCCTGACCA CTTTGCCCAG 
CGACAGAGCT GCATGAATAC GTTTGCCAGC TGGTTTGGCT ACATGCCGCT GATCCACTCT 
CAGATGAGGC TCGACCCCGT CCTCTTTAAA GACCAGGTCT CTATTTTGAG GAAGAAATAC 
CGAGACATTG AGCGACTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000118.2
CDS	781..3021
Translation	MQAKKRYFILLSAGSCLALLFYFGGLQFRASRSHSRREEHSGRNGLHHPSPDHFWPRFPDALRPFVPWDQLENEDSSVHISPRQKRDANSSIYKGKKCRMESCFDFTLCKKNGFKVYVYPQQKGEKIAESYQNILAAIEGSRFYTSDPSQACLFVLSLDTLDRDQLSPQYVHNLRSKVQSLHLWNNGRNHLIFNLYSGTWPDYTEDVGFDIGQAMLAKASISTENFRPNFDVSIPLFSKDHPRTGGERGFLKFNTIPPLRKYMLVFKGKRYLTGIGSDTRNALYHVHNGEDVVLLTTCKHGKDWQKHKDSRCDRDNTEYEKYDYREMLHNATFCLVPRGRRLGSFRFLEALQAACVPVMLSNGWELPFSEVINWNQAAVIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEAYFSSVEKIVLTTLEIIQDRIFKHISRNSLIWNKHPGGLFVLPQYSSYLGDFPYYYANLGLKPPSKFTAVIHAVTPLVSQSQPVLKLLVAAAKSQYCAQIIVLWNCDKPLPAKHRWPATAVPVVVIEGESKVMSSRFLPYDNIITDAVLSLDEDTVLSTTEVDFAFTVWQSFPERIVGYPARSHFWDNSKERWGYTSKWTNDYSMVLTGAAIYHKYYHYLYSHYLPASLKNMVDQLANCEDILMNFLVSAVTKLPPIKVTQKKQYKETMMGQTSRASRWADPDHFAQRQSCMNTFASWFGYMPLIHSQMRLDPVLFKDQVSILRKKYRDIERL

Target ORF information:

RefSeq Version	NM_000127.3
Organism	Homo sapiens(human)
Definition	Homo sapiens exostosin glycosyltransferase 1 (EXT1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000127.3

ORF Insert Sequence:

ATGCAGGCCA AAAAACGCTA TTTCATCCTG CTCTCAGCTG GCTCTTGTCT CGCCCTTTTG 
TTTTATTTCG GAGGCTTGCA GTTTAGGGCA TCGAGGAGCC ACAGCCGGAG AGAAGAACAC 
AGCGGTAGGA ATGGCTTGCA CCACCCCAGT CCGGATCATT TCTGGCCCCG CTTCCCGGAC 
GCTCTGCGCC CCTTCGTTCC TTGGGATCAA TTGGAAAACG AGGATTCCAG CGTGCACATT 
TCCCCCCGGC AGAAGCGAGA TGCCAACTCC AGCATCTACA AAGGCAAGAA GTGCCGCATG 
GAGTCCTGCT TCGATTTCAC CCTTTGCAAG AAAAACGGCT TCAAAGTCTA CGTATACCCA 
CAGCAAAAAG GGGAGAAAAT CGCCGAAAGT TACCAAAACA TTCTAGCGGC CATCGAGGGC 
TCCAGGTTCT ACACCTCGGA CCCCAGCCAG GCGTGCCTCT TTGTCCTGAG TCTGGATACT 
TTAGACAGAG ACCAGTTGTC ACCTCAGTAT GTGCACAATT TGAGATCCAA AGTGCAGAGT 
CTCCACTTGT GGAACAATGG TAGGAATCAT TTAATTTTTA ATTTATATTC CGGCACTTGG 
CCTGACTACA CCGAGGACGT GGGGTTTGAC ATCGGCCAGG CGATGCTGGC CAAAGCCAGC 
ATCAGTACTG AAAACTTCCG ACCCAACTTT GATGTTTCTA TTCCCCTCTT TTCTAAGGAT 
CATCCCAGGA CAGGAGGGGA GAGGGGGTTT TTGAAGTTCA ACACCATCCC TCCTCTCAGG 
AAGTACATGC TGGTATTCAA GGGGAAGAGG TACCTGACAG GGATAGGATC AGACACCAGG 
AATGCCTTAT ATCACGTCCA TAACGGGGAG GACGTTGTGC TCCTCACCAC CTGCAAGCAT 
GGCAAAGACT GGCAAAAGCA CAAGGATTCT CGCTGTGACA GAGACAACAC CGAGTATGAG 
AAGTATGATT ATCGGGAAAT GCTGCACAAT GCCACTTTCT GTCTGGTTCC TCGTGGTCGC 
AGGCTTGGGT CCTTCAGATT CCTGGAGGCT TTGCAGGCTG CCTGCGTCCC TGTGATGCTC 
AGCAATGGAT GGGAGTTGCC ATTCTCTGAA GTGATTAATT GGAACCAAGC TGCCGTCATA 
GGCGATGAGA GATTGTTATT ACAGATTCCT TCTACAATCA GGTCTATTCA TCAGGATAAA 
ATCCTAGCAC TTAGACAGCA GACACAATTC TTGTGGGAGG CTTATTTTTC TTCAGTTGAG 
AAGATTGTAT TAACTACACT AGAGATTATT CAGGACAGAA TATTCAAGCA CATATCACGT 
AACAGTTTAA TATGGAACAA ACATCCTGGA GGATTGTTCG TACTACCACA GTATTCATCT 
TATCTGGGAG ATTTTCCTTA CTACTATGCT AATTTAGGTT TAAAGCCCCC CTCCAAATTC 
ACTGCAGTCA TCCATGCGGT GACCCCCCTG GTCTCTCAGT CCCAGCCAGT GTTGAAGCTT 
CTCGTGGCTG CAGCCAAGTC CCAGTACTGT GCCCAGATCA TAGTTCTATG GAATTGTGAC 
AAGCCCCTAC CAGCCAAACA CCGCTGGCCT GCCACTGCTG TGCCTGTCGT CGTCATTGAA 
GGAGAGAGCA AGGTTATGAG CAGCCGTTTT CTGCCCTACG ACAACATCAT CACAGACGCC 
GTGCTCAGCC TTGACGAGGA CACGGTGCTT TCAACAACAG AGGTGGATTT CGCCTTCACA 
GTGTGGCAGA GCTTCCCTGA GAGGATTGTG GGGTACCCCG CGCGCAGCCA CTTCTGGGAT 
AACTCTAAGG AGCGGTGGGG ATACACATCA AAGTGGACGA ACGACTACTC CATGGTGTTG 
ACAGGAGCTG CTATTTACCA CAAATATTAT CACTACCTAT ACTCCCATTA CCTGCCAGCC 
AGCCTGAAGA ACATGGTGGA CCAATTGGCC AATTGTGAGG ACATTCTCAT GAACTTCCTG 
GTGTCTGCTG TGACAAAATT GCCTCCAATC AAAGTGACCC AGAAGAAGCA GTATAAGGAG 
ACAATGATGG GACAGACTTC TCGGGCTTCC CGTTGGGCTG ACCCTGACCA CTTTGCCCAG 
CGACAGAGCT GCATGAATAC GTTTGCCAGC TGGTTTGGCT ACATGCCGCT GATCCACTCT 
CAGATGAGGC TCGACCCCGT CCTCTTTAAA GACCAGGTCT CTATTTTGAG GAAGAAATAC 
CGAGACATTG AGCGACTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EXT1 ( NM_000127.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000118.2 Homo sapiens exostosin glycosyltransferase 1 (EXT1), mRNA.

Price & Availability↑

CloneID	OHu17950
Clone ID Related Accession (Same CDS sequence)	NM_000127.3 , NM_000127.2
Accession Version	NM_000127.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2241bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1561910400000
Organism	Homo sapiens(human)
Product	exostosin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U70539.1 and BC001174.1. This sequence is a reference standard in the RefSeqGene project. On Apr 14, 2004 this sequence version replaced NM_000127.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC001174.1, S79639.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGGCCA AAAAACGCTA TTTCATCCTG CTCTCAGCTG GCTCTTGTCT CGCCCTTTTG 
TTTTATTTCG GAGGCTTGCA GTTTAGGGCA TCGAGGAGCC ACAGCCGGAG AGAAGAACAC 
AGCGGTAGGA ATGGCTTGCA CCACCCCAGT CCGGATCATT TCTGGCCCCG CTTCCCGGAC 
GCTCTGCGCC CCTTCGTTCC TTGGGATCAA TTGGAAAACG AGGATTCCAG CGTGCACATT 
TCCCCCCGGC AGAAGCGAGA TGCCAACTCC AGCATCTACA AAGGCAAGAA GTGCCGCATG 
GAGTCCTGCT TCGATTTCAC CCTTTGCAAG AAAAACGGCT TCAAAGTCTA CGTATACCCA 
CAGCAAAAAG GGGAGAAAAT CGCCGAAAGT TACCAAAACA TTCTAGCGGC CATCGAGGGC 
TCCAGGTTCT ACACCTCGGA CCCCAGCCAG GCGTGCCTCT TTGTCCTGAG TCTGGATACT 
TTAGACAGAG ACCAGTTGTC ACCTCAGTAT GTGCACAATT TGAGATCCAA AGTGCAGAGT 
CTCCACTTGT GGAACAATGG TAGGAATCAT TTAATTTTTA ATTTATATTC CGGCACTTGG 
CCTGACTACA CCGAGGACGT GGGGTTTGAC ATCGGCCAGG CGATGCTGGC CAAAGCCAGC 
ATCAGTACTG AAAACTTCCG ACCCAACTTT GATGTTTCTA TTCCCCTCTT TTCTAAGGAT 
CATCCCAGGA CAGGAGGGGA GAGGGGGTTT TTGAAGTTCA ACACCATCCC TCCTCTCAGG 
AAGTACATGC TGGTATTCAA GGGGAAGAGG TACCTGACAG GGATAGGATC AGACACCAGG 
AATGCCTTAT ATCACGTCCA TAACGGGGAG GACGTTGTGC TCCTCACCAC CTGCAAGCAT 
GGCAAAGACT GGCAAAAGCA CAAGGATTCT CGCTGTGACA GAGACAACAC CGAGTATGAG 
AAGTATGATT ATCGGGAAAT GCTGCACAAT GCCACTTTCT GTCTGGTTCC TCGTGGTCGC 
AGGCTTGGGT CCTTCAGATT CCTGGAGGCT TTGCAGGCTG CCTGCGTCCC TGTGATGCTC 
AGCAATGGAT GGGAGTTGCC ATTCTCTGAA GTGATTAATT GGAACCAAGC TGCCGTCATA 
GGCGATGAGA GATTGTTATT ACAGATTCCT TCTACAATCA GGTCTATTCA TCAGGATAAA 
ATCCTAGCAC TTAGACAGCA GACACAATTC TTGTGGGAGG CTTATTTTTC TTCAGTTGAG 
AAGATTGTAT TAACTACACT AGAGATTATT CAGGACAGAA TATTCAAGCA CATATCACGT 
AACAGTTTAA TATGGAACAA ACATCCTGGA GGATTGTTCG TACTACCACA GTATTCATCT 
TATCTGGGAG ATTTTCCTTA CTACTATGCT AATTTAGGTT TAAAGCCCCC CTCCAAATTC 
ACTGCAGTCA TCCATGCGGT GACCCCCCTG GTCTCTCAGT CCCAGCCAGT GTTGAAGCTT 
CTCGTGGCTG CAGCCAAGTC CCAGTACTGT GCCCAGATCA TAGTTCTATG GAATTGTGAC 
AAGCCCCTAC CAGCCAAACA CCGCTGGCCT GCCACTGCTG TGCCTGTCGT CGTCATTGAA 
GGAGAGAGCA AGGTTATGAG CAGCCGTTTT CTGCCCTACG ACAACATCAT CACAGACGCC 
GTGCTCAGCC TTGACGAGGA CACGGTGCTT TCAACAACAG AGGTGGATTT CGCCTTCACA 
GTGTGGCAGA GCTTCCCTGA GAGGATTGTG GGGTACCCCG CGCGCAGCCA CTTCTGGGAT 
AACTCTAAGG AGCGGTGGGG ATACACATCA AAGTGGACGA ACGACTACTC CATGGTGTTG 
ACAGGAGCTG CTATTTACCA CAAATATTAT CACTACCTAT ACTCCCATTA CCTGCCAGCC 
AGCCTGAAGA ACATGGTGGA CCAATTGGCC AATTGTGAGG ACATTCTCAT GAACTTCCTG 
GTGTCTGCTG TGACAAAATT GCCTCCAATC AAAGTGACCC AGAAGAAGCA GTATAAGGAG 
ACAATGATGG GACAGACTTC TCGGGCTTCC CGTTGGGCTG ACCCTGACCA CTTTGCCCAG 
CGACAGAGCT GCATGAATAC GTTTGCCAGC TGGTTTGGCT ACATGCCGCT GATCCACTCT 
CAGATGAGGC TCGACCCCGT CCTCTTTAAA GACCAGGTCT CTATTTTGAG GAAGAAATAC 
CGAGACATTG AGCGACTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000118.2
CDS	774..3014
Translation	MQAKKRYFILLSAGSCLALLFYFGGLQFRASRSHSRREEHSGRNGLHHPSPDHFWPRFPDALRPFVPWDQLENEDSSVHISPRQKRDANSSIYKGKKCRMESCFDFTLCKKNGFKVYVYPQQKGEKIAESYQNILAAIEGSRFYTSDPSQACLFVLSLDTLDRDQLSPQYVHNLRSKVQSLHLWNNGRNHLIFNLYSGTWPDYTEDVGFDIGQAMLAKASISTENFRPNFDVSIPLFSKDHPRTGGERGFLKFNTIPPLRKYMLVFKGKRYLTGIGSDTRNALYHVHNGEDVVLLTTCKHGKDWQKHKDSRCDRDNTEYEKYDYREMLHNATFCLVPRGRRLGSFRFLEALQAACVPVMLSNGWELPFSEVINWNQAAVIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEAYFSSVEKIVLTTLEIIQDRIFKHISRNSLIWNKHPGGLFVLPQYSSYLGDFPYYYANLGLKPPSKFTAVIHAVTPLVSQSQPVLKLLVAAAKSQYCAQIIVLWNCDKPLPAKHRWPATAVPVVVIEGESKVMSSRFLPYDNIITDAVLSLDEDTVLSTTEVDFAFTVWQSFPERIVGYPARSHFWDNSKERWGYTSKWTNDYSMVLTGAAIYHKYYHYLYSHYLPASLKNMVDQLANCEDILMNFLVSAVTKLPPIKVTQKKQYKETMMGQTSRASRWADPDHFAQRQSCMNTFASWFGYMPLIHSQMRLDPVLFKDQVSILRKKYRDIERL

Target ORF information:

RefSeq Version	NM_000127.2
Organism	Homo sapiens(human)
Definition	Homo sapiens exostosin glycosyltransferase 1 (EXT1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000127.2

ORF Insert Sequence:

ATGCAGGCCA AAAAACGCTA TTTCATCCTG CTCTCAGCTG GCTCTTGTCT CGCCCTTTTG 
TTTTATTTCG GAGGCTTGCA GTTTAGGGCA TCGAGGAGCC ACAGCCGGAG AGAAGAACAC 
AGCGGTAGGA ATGGCTTGCA CCACCCCAGT CCGGATCATT TCTGGCCCCG CTTCCCGGAC 
GCTCTGCGCC CCTTCGTTCC TTGGGATCAA TTGGAAAACG AGGATTCCAG CGTGCACATT 
TCCCCCCGGC AGAAGCGAGA TGCCAACTCC AGCATCTACA AAGGCAAGAA GTGCCGCATG 
GAGTCCTGCT TCGATTTCAC CCTTTGCAAG AAAAACGGCT TCAAAGTCTA CGTATACCCA 
CAGCAAAAAG GGGAGAAAAT CGCCGAAAGT TACCAAAACA TTCTAGCGGC CATCGAGGGC 
TCCAGGTTCT ACACCTCGGA CCCCAGCCAG GCGTGCCTCT TTGTCCTGAG TCTGGATACT 
TTAGACAGAG ACCAGTTGTC ACCTCAGTAT GTGCACAATT TGAGATCCAA AGTGCAGAGT 
CTCCACTTGT GGAACAATGG TAGGAATCAT TTAATTTTTA ATTTATATTC CGGCACTTGG 
CCTGACTACA CCGAGGACGT GGGGTTTGAC ATCGGCCAGG CGATGCTGGC CAAAGCCAGC 
ATCAGTACTG AAAACTTCCG ACCCAACTTT GATGTTTCTA TTCCCCTCTT TTCTAAGGAT 
CATCCCAGGA CAGGAGGGGA GAGGGGGTTT TTGAAGTTCA ACACCATCCC TCCTCTCAGG 
AAGTACATGC TGGTATTCAA GGGGAAGAGG TACCTGACAG GGATAGGATC AGACACCAGG 
AATGCCTTAT ATCACGTCCA TAACGGGGAG GACGTTGTGC TCCTCACCAC CTGCAAGCAT 
GGCAAAGACT GGCAAAAGCA CAAGGATTCT CGCTGTGACA GAGACAACAC CGAGTATGAG 
AAGTATGATT ATCGGGAAAT GCTGCACAAT GCCACTTTCT GTCTGGTTCC TCGTGGTCGC 
AGGCTTGGGT CCTTCAGATT CCTGGAGGCT TTGCAGGCTG CCTGCGTCCC TGTGATGCTC 
AGCAATGGAT GGGAGTTGCC ATTCTCTGAA GTGATTAATT GGAACCAAGC TGCCGTCATA 
GGCGATGAGA GATTGTTATT ACAGATTCCT TCTACAATCA GGTCTATTCA TCAGGATAAA 
ATCCTAGCAC TTAGACAGCA GACACAATTC TTGTGGGAGG CTTATTTTTC TTCAGTTGAG 
AAGATTGTAT TAACTACACT AGAGATTATT CAGGACAGAA TATTCAAGCA CATATCACGT 
AACAGTTTAA TATGGAACAA ACATCCTGGA GGATTGTTCG TACTACCACA GTATTCATCT 
TATCTGGGAG ATTTTCCTTA CTACTATGCT AATTTAGGTT TAAAGCCCCC CTCCAAATTC 
ACTGCAGTCA TCCATGCGGT GACCCCCCTG GTCTCTCAGT CCCAGCCAGT GTTGAAGCTT 
CTCGTGGCTG CAGCCAAGTC CCAGTACTGT GCCCAGATCA TAGTTCTATG GAATTGTGAC 
AAGCCCCTAC CAGCCAAACA CCGCTGGCCT GCCACTGCTG TGCCTGTCGT CGTCATTGAA 
GGAGAGAGCA AGGTTATGAG CAGCCGTTTT CTGCCCTACG ACAACATCAT CACAGACGCC 
GTGCTCAGCC TTGACGAGGA CACGGTGCTT TCAACAACAG AGGTGGATTT CGCCTTCACA 
GTGTGGCAGA GCTTCCCTGA GAGGATTGTG GGGTACCCCG CGCGCAGCCA CTTCTGGGAT 
AACTCTAAGG AGCGGTGGGG ATACACATCA AAGTGGACGA ACGACTACTC CATGGTGTTG 
ACAGGAGCTG CTATTTACCA CAAATATTAT CACTACCTAT ACTCCCATTA CCTGCCAGCC 
AGCCTGAAGA ACATGGTGGA CCAATTGGCC AATTGTGAGG ACATTCTCAT GAACTTCCTG 
GTGTCTGCTG TGACAAAATT GCCTCCAATC AAAGTGACCC AGAAGAAGCA GTATAAGGAG 
ACAATGATGG GACAGACTTC TCGGGCTTCC CGTTGGGCTG ACCCTGACCA CTTTGCCCAG 
CGACAGAGCT GCATGAATAC GTTTGCCAGC TGGTTTGGCT ACATGCCGCT GATCCACTCT 
CAGATGAGGC TCGACCCCGT CCTCTTTAAA GACCAGGTCT CTATTTTGAG GAAGAAATAC 
CGAGACATTG AGCGACTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

[Analysis of EXT1 and EXT2 gene mutations in two Chinese pedigrees affected with hereditary multiple exostosis].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics36(5)451-455(2019 May)
Bai Y,Liu N,Hu S,Wu Q,Kong X

A novel splice mutation induces exon skipping of the EXT1 gene in patients with hereditary multiple exostoses.
International journal of oncology54(3)859-868(2019 Mar)
Guo X,Lin M,Yan W,Chen W,Hong G

The role of EXT1 gene mutation and its high expression of calcitonin gene-related peptide in the development of multiple exostosis.
Biochemical and biophysical research communications505(4)959-965(2018 11)
Wu ZY,Wang Y,Wang JW,Chen YZ,Guo Y

Heterogeneous spectrum of EXT gene mutations in Chinese patients with hereditary multiple osteochondromas.
Medicine97(42)e12855(2018 Oct)
Li Y,Wang J,Tang J,Wang Z,Han B,Li N,Yu T,Chen Y,Fu Q

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EXT1 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Target ORF information:

ORF Insert Sequence:

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