SERPINB1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SERPINB1
Entrez Gene ID	1992
Full Name	serpin family B member 1
Synonyms	EI,ELANH2,HEL-S-27,HEL57,LEI,M/NEI,MNEI,PI-2,PI2
General protein information	Preferred Names serpin family B member 1 Names leukocyte elastase inhibitor epididymis luminal protein 57 epididymis secretory protein Li 27 peptidase inhibitor 2 protease inhibitor 2 (anti-elastase), monocyte/neutrophil derived serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p25.2
Summary	The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
Disorder MIM:	130135

mRNA and Protein(s)

mRNA	Protein	Name
NM_030666.4	NP_109591.1	leukocyte elastase inhibitor
NM_030666.3	NP_109591.1	leukocyte elastase inhibitor
XM_011514334.2	XP_011512636.1	leukocyte elastase inhibitor isoform X1
XM_011514335.2	XP_011512637.1	leukocyte elastase inhibitor isoform X2
XM_011514334.1	XP_011512636.1	leukocyte elastase inhibitor isoform X1
XM_011514333.1	XP_011512635.1	leukocyte elastase inhibitor isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	SERPINB1	NP_109591.1
Macaca mulatta (Rhesus monkey)	SERPINB1	XP_001091038.1
Danio rerio (zebrafish)	serpinb1	NP_001002653.1
Danio rerio (zebrafish)	LOC569077	NP_001188383.1
Bos taurus (cattle)	SERPINB1	NP_001193539.1
Pan troglodytes (chimpanzee)	SERPINB1	XP_003311063.1
Canis lupus familiaris (dog)	SERPINB1	XP_005640211.1
Mus musculus (house mouse)	Serpinb1a	NP_079705.2
Danio rerio (zebrafish)	serpinb1l2	NP_001038636.1
Rattus norvegicus (Norway rat)	Serpinb1a	NP_001026812.1
Xenopus tropicalis (tropical clawed frog)	serpinb1	NP_001011419.1

Gene Ontology
Bibliography

Related articles in PubMed

SERPINB1-mediated checkpoint of inflammatory caspase activation.
Choi YJ, Kim S, Choi Y, Nielsen TB, Yan J, Lu A, Ruan J, Lee HR, Wu H, Spellberg B, Jung JU
Nature immunology20(3)276-287(2019 03)

Sex-specific genetic predictors of Alzheimer's disease biomarkers.
Deming Y, Dumitrescu L, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Moghekar A, Del Aguila JL, Fernandez MV, Budde J, Hassenstab J, Fagan AM, Riemenschneider M, Petersen RC, Minthon L, Chao MJ, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Peskind ER, Li G, Davis LK, Sealock JM, Cox NJ, , , Goate AM, Bennett DA, Schneider JA, Jefferson AL, Cruchaga C, Hohman TJ
Acta neuropathologica136(6)857-872(2018 12)

Proteomic Profiling and Differential Messenger RNA Expression Correlate HSP27 and Serpin Family B Member 1 to Apical Periodontitis Outcomes.
Cavalla F, Biguetti C, Jain S, Johnson C, Letra A, Garlet GP, Silva RM
Journal of endodontics43(9)1486-1493(2017 Sep)

SERPINB1 ameliorates acute lung injury in liver transplantation through ERK1/2-mediated STAT3-dependent HO-1 induction.
Yao W, Li H, Luo G, Li X, Chen C, Yuan D, Chi X, Xia Z, Hei Z
Free radical biology & medicine108542-553(2017 07)

Human gingiva transcriptome during wound healing.
Wang Y, Tatakis DN
Journal of clinical periodontology44(4)394-402(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SERPINB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SERPINB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu57455	XM_011514335.2 Latest version!	Homo sapiens serpin family B member 1 (SERPINB1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu14050	NM_030666.4 Latest version!	Homo sapiens serpin family B member 1 (SERPINB1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
OHu14050	XM_011514333.1 Latest version!	Homo sapiens serpin family B member 1 (SERPINB1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
OHu14050	XM_011514334.2 Latest version!	Homo sapiens serpin family B member 1 (SERPINB1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
View Old Accession Versions >>
OHu14050	NM_030666.3	Homo sapiens serpin family B member 1 (SERPINB1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
OHu14050	XM_011514334.1	Homo sapiens serpin peptidase inhibitor, clade B (ovalbumin), member 1 (SERPINB1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SERPINB1 ( XM_011514335.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011512637.1 Homo sapiens serpin family B member 1 (SERPINB1), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu57455
Clone ID Related Accession (Same CDS sequence)	XM_011514335.2
Accession Version	XM_011514335.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	leukocyte elastase inhibitor isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011514335.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACAGTC TGCATGGAAA GACTTTCCAT TTCAACACGG TTGAAGAGGT TCATTCAAGA 
TTCCAGAGTC TGAATGCTGA TATCAACAAA CGTGGAGCGT CTTATATTCT GAAACTTGCT 
AATAGATTAT ATGGAGAGAA AACTTACAAT TTCCTTCCTG AGTTCTTGGT TTCGACTCAG 
AAAACATATG GTGCTGACCT GGCCAGTGTG GATTTTCAGC ATGCCTCTGA AGATGCAAGG 
AAGACCATAA ACCAGTGGGT CAAAGGACAG ACAGAAGGAA AAATTCCGGA ACTGTTGGCT 
TCGGGCATGG TTGATAACAT GACCAAACTT GTGCTAGTAA ATGCCATCTA TTTCAAGGGA 
AACTGGAAGG ATAAATTCAT GAAAGAAGCC ACGACGAATG CACCATTCAG ATTGAATAAG 
AAAGACAGAA AAACTGTGAA AATGATGTAT CAGAAGAAAA AATTTGCATA TGGCTACATC 
GAGGACCTTA AGTGCCGTGT GCTGGAACTG CCTTACCAAG GCGAGGAGCT CAGCATGGTC 
ATCCTGCTGC CGGATGACAT TGAGGACGAG TCCACGGGCC TGAAGAAGAT TGAGGAACAG 
TTGACTTTGG AAAAGTTGCA TGAGTGGACT AAACCTGAGA ATCTCGATTT CATTGAAGTT 
AATGTCAGCT TGCCCAGGTT CAAACTGGAA GAGAGTTACA CTCTCAACTC CGACCTCGCC 
CGCCTAGGTG TGCAGGATCT CTTTAACAGT AGCAAGGCTG ATCTGTCTGG CATGTCAGGA 
GCCAGAGATA TTTTTATATC AAAAATTGTC CACAAGTCAT TTGTGGAAGT GAATGAAGAG 
GGAACAGAGG CGGCAGCTGC CACAGCAGGC ATCGCAACTT TCTGCATGTT GATGCCCGAA 
GAAAATTTCA CTGCCGACCA TCCATTCCTT TTCTTTATTC GGCATAATTC CTCAGGTAGC 
ATCCTATTCT TGGGGAGATT TTCTTCCCCT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011512637.1
CDS	383..1375
Translation	MDSLHGKTFHFNTVEEVHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQHASEDARKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKTVKMMYQKKKFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEKLHEWTKPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSKADLSGMSGARDIFISKIVHKSFVEVNEEGTEAAAATAGIATFCMLMPEENFTADHPFLFFIRHNSSGSILFLGRFSSP

Target ORF information:

RefSeq Version	XM_011514335.2
Organism	Homo sapiens(human)
Definition	Homo sapiens serpin family B member 1 (SERPINB1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011514335.2

ORF Insert Sequence:

ATGGACAGTC TGCATGGAAA GACTTTCCAT TTCAACACGG TTGAAGAGGT TCATTCAAGA 
TTCCAGAGTC TGAATGCTGA TATCAACAAA CGTGGAGCGT CTTATATTCT GAAACTTGCT 
AATAGATTAT ATGGAGAGAA AACTTACAAT TTCCTTCCTG AGTTCTTGGT TTCGACTCAG 
AAAACATATG GTGCTGACCT GGCCAGTGTG GATTTTCAGC ATGCCTCTGA AGATGCAAGG 
AAGACCATAA ACCAGTGGGT CAAAGGACAG ACAGAAGGAA AAATTCCGGA ACTGTTGGCT 
TCGGGCATGG TTGATAACAT GACCAAACTT GTGCTAGTAA ATGCCATCTA TTTCAAGGGA 
AACTGGAAGG ATAAATTCAT GAAAGAAGCC ACGACGAATG CACCATTCAG ATTGAATAAG 
AAAGACAGAA AAACTGTGAA AATGATGTAT CAGAAGAAAA AATTTGCATA TGGCTACATC 
GAGGACCTTA AGTGCCGTGT GCTGGAACTG CCTTACCAAG GCGAGGAGCT CAGCATGGTC 
ATCCTGCTGC CGGATGACAT TGAGGACGAG TCCACGGGCC TGAAGAAGAT TGAGGAACAG 
TTGACTTTGG AAAAGTTGCA TGAGTGGACT AAACCTGAGA ATCTCGATTT CATTGAAGTT 
AATGTCAGCT TGCCCAGGTT CAAACTGGAA GAGAGTTACA CTCTCAACTC CGACCTCGCC 
CGCCTAGGTG TGCAGGATCT CTTTAACAGT AGCAAGGCTG ATCTGTCTGG CATGTCAGGA 
GCCAGAGATA TTTTTATATC AAAAATTGTC CACAAGTCAT TTGTGGAAGT GAATGAAGAG 
GGAACAGAGG CGGCAGCTGC CACAGCAGGC ATCGCAACTT TCTGCATGTT GATGCCCGAA 
GAAAATTTCA CTGCCGACCA TCCATTCCTT TTCTTTATTC GGCATAATTC CTCAGGTAGC 
ATCCTATTCT TGGGGAGATT TTCTTCCCCT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SERPINB1 ( NM_030666.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_109591.1 Homo sapiens serpin family B member 1 (SERPINB1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu14050
Clone ID Related Accession (Same CDS sequence)	NM_030666.4 , NM_030666.3 , XM_011514334.2 , XM_011514334.1 , XM_011514333.1
Accession Version	NM_030666.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1140bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	leukocyte elastase inhibitor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK309765.1, BC009015.1, BM785367.1, BM823453.1 and AW451326.1. On Nov 22, 2018 this sequence version replaced NM_030666.3. Transcript Variant: This variant (1) encodes the functional protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.321707.1, SRR3476690.516627.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000380739.6/ ENSP00000370115.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGCAGC TGAGCTCAGC AAACACCCGC TTCGCCTTGG ACCTGTTCCT GGCGTTGAGT 
GAGAACAATC CGGCTGGAAA CATCTTCATC TCTCCCTTCA GCATTTCATC TGCTATGGCC 
ATGGTTTTTC TGGGGACCAG AGGTAACACG GCAGCACAGC TGTCCAAGAC TTTCCATTTC 
AACACGGTTG AAGAGGTTCA TTCAAGATTC CAGAGTCTGA ATGCTGATAT CAACAAACGT 
GGAGCGTCTT ATATTCTGAA ACTTGCTAAT AGATTATATG GAGAGAAAAC TTACAATTTC 
CTTCCTGAGT TCTTGGTTTC GACTCAGAAA ACATATGGTG CTGACCTGGC CAGTGTGGAT 
TTTCAGCATG CCTCTGAAGA TGCAAGGAAG ACCATAAACC AGTGGGTCAA AGGACAGACA 
GAAGGAAAAA TTCCGGAACT GTTGGCTTCG GGCATGGTTG ATAACATGAC CAAACTTGTG 
CTAGTAAATG CCATCTATTT CAAGGGAAAC TGGAAGGATA AATTCATGAA AGAAGCCACG 
ACGAATGCAC CATTCAGATT GAATAAGAAA GACAGAAAAA CTGTGAAAAT GATGTATCAG 
AAGAAAAAAT TTGCATATGG CTACATCGAG GACCTTAAGT GCCGTGTGCT GGAACTGCCT 
TACCAAGGCG AGGAGCTCAG CATGGTCATC CTGCTGCCGG ATGACATTGA GGACGAGTCC 
ACGGGCCTGA AGAAGATTGA GGAACAGTTG ACTTTGGAAA AGTTGCATGA GTGGACTAAA 
CCTGAGAATC TCGATTTCAT TGAAGTTAAT GTCAGCTTGC CCAGGTTCAA ACTGGAAGAG 
AGTTACACTC TCAACTCCGA CCTCGCCCGC CTAGGTGTGC AGGATCTCTT TAACAGTAGC 
AAGGCTGATC TGTCTGGCAT GTCAGGAGCC AGAGATATTT TTATATCAAA AATTGTCCAC 
AAGTCATTTG TGGAAGTGAA TGAAGAGGGA ACAGAGGCGG CAGCTGCCAC AGCAGGCATC 
GCAACTTTCT GCATGTTGAT GCCCGAAGAA AATTTCACTG CCGACCATCC ATTCCTTTTC 
TTTATTCGGC ATAATTCCTC AGGTAGCATC CTATTCTTGG GGAGATTTTC TTCCCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_109591.1
CDS	61..1200
Translation	MEQLSSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHFNTVEEVHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQHASEDARKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKTVKMMYQKKKFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEKLHEWTKPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSKADLSGMSGARDIFISKIVHKSFVEVNEEGTEAAAATAGIATFCMLMPEENFTADHPFLFFIRHNSSGSILFLGRFSSP

Target ORF information:

RefSeq Version	NM_030666.4
Organism	Homo sapiens(human)
Definition	Homo sapiens serpin family B member 1 (SERPINB1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030666.4

ORF Insert Sequence:

ATGGAGCAGC TGAGCTCAGC AAACACCCGC TTCGCCTTGG ACCTGTTCCT GGCGTTGAGT 
GAGAACAATC CGGCTGGAAA CATCTTCATC TCTCCCTTCA GCATTTCATC TGCTATGGCC 
ATGGTTTTTC TGGGGACCAG AGGTAACACG GCAGCACAGC TGTCCAAGAC TTTCCATTTC 
AACACGGTTG AAGAGGTTCA TTCAAGATTC CAGAGTCTGA ATGCTGATAT CAACAAACGT 
GGAGCGTCTT ATATTCTGAA ACTTGCTAAT AGATTATATG GAGAGAAAAC TTACAATTTC 
CTTCCTGAGT TCTTGGTTTC GACTCAGAAA ACATATGGTG CTGACCTGGC CAGTGTGGAT 
TTTCAGCATG CCTCTGAAGA TGCAAGGAAG ACCATAAACC AGTGGGTCAA AGGACAGACA 
GAAGGAAAAA TTCCGGAACT GTTGGCTTCG GGCATGGTTG ATAACATGAC CAAACTTGTG 
CTAGTAAATG CCATCTATTT CAAGGGAAAC TGGAAGGATA AATTCATGAA AGAAGCCACG 
ACGAATGCAC CATTCAGATT GAATAAGAAA GACAGAAAAA CTGTGAAAAT GATGTATCAG 
AAGAAAAAAT TTGCATATGG CTACATCGAG GACCTTAAGT GCCGTGTGCT GGAACTGCCT 
TACCAAGGCG AGGAGCTCAG CATGGTCATC CTGCTGCCGG ATGACATTGA GGACGAGTCC 
ACGGGCCTGA AGAAGATTGA GGAACAGTTG ACTTTGGAAA AGTTGCATGA GTGGACTAAA 
CCTGAGAATC TCGATTTCAT TGAAGTTAAT GTCAGCTTGC CCAGGTTCAA ACTGGAAGAG 
AGTTACACTC TCAACTCCGA CCTCGCCCGC CTAGGTGTGC AGGATCTCTT TAACAGTAGC 
AAGGCTGATC TGTCTGGCAT GTCAGGAGCC AGAGATATTT TTATATCAAA AATTGTCCAC 
AAGTCATTTG TGGAAGTGAA TGAAGAGGGA ACAGAGGCGG CAGCTGCCAC AGCAGGCATC 
GCAACTTTCT GCATGTTGAT GCCCGAAGAA AATTTCACTG CCGACCATCC ATTCCTTTTC 
TTTATTCGGC ATAATTCCTC AGGTAGCATC CTATTCTTGG GGAGATTTTC TTCCCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SERPINB1 ( NM_030666.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_109591.1 Homo sapiens serpin family B member 1 (SERPINB1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu14050
Clone ID Related Accession (Same CDS sequence)	NM_030666.4 , NM_030666.3 , XM_011514334.2 , XM_011514334.1 , XM_011514333.1
Accession Version	NM_030666.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1140bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506787200000
Organism	Homo sapiens(human)
Product	leukocyte elastase inhibitor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK309765.1, BC009015.1, BM785367.1, BM823453.1 and AW451326.1. On Aug 18, 2012 this sequence version replaced NM_030666.2. Transcript Variant: This variant (1) encodes the functional protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.177365.1, SRR1803614.228696.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCAGC TGAGCTCAGC AAACACCCGC TTCGCCTTGG ACCTGTTCCT GGCGTTGAGT 
GAGAACAATC CGGCTGGAAA CATCTTCATC TCTCCCTTCA GCATTTCATC TGCTATGGCC 
ATGGTTTTTC TGGGGACCAG AGGTAACACG GCAGCACAGC TGTCCAAGAC TTTCCATTTC 
AACACGGTTG AAGAGGTTCA TTCAAGATTC CAGAGTCTGA ATGCTGATAT CAACAAACGT 
GGAGCGTCTT ATATTCTGAA ACTTGCTAAT AGATTATATG GAGAGAAAAC TTACAATTTC 
CTTCCTGAGT TCTTGGTTTC GACTCAGAAA ACATATGGTG CTGACCTGGC CAGTGTGGAT 
TTTCAGCATG CCTCTGAAGA TGCAAGGAAG ACCATAAACC AGTGGGTCAA AGGACAGACA 
GAAGGAAAAA TTCCGGAACT GTTGGCTTCG GGCATGGTTG ATAACATGAC CAAACTTGTG 
CTAGTAAATG CCATCTATTT CAAGGGAAAC TGGAAGGATA AATTCATGAA AGAAGCCACG 
ACGAATGCAC CATTCAGATT GAATAAGAAA GACAGAAAAA CTGTGAAAAT GATGTATCAG 
AAGAAAAAAT TTGCATATGG CTACATCGAG GACCTTAAGT GCCGTGTGCT GGAACTGCCT 
TACCAAGGCG AGGAGCTCAG CATGGTCATC CTGCTGCCGG ATGACATTGA GGACGAGTCC 
ACGGGCCTGA AGAAGATTGA GGAACAGTTG ACTTTGGAAA AGTTGCATGA GTGGACTAAA 
CCTGAGAATC TCGATTTCAT TGAAGTTAAT GTCAGCTTGC CCAGGTTCAA ACTGGAAGAG 
AGTTACACTC TCAACTCCGA CCTCGCCCGC CTAGGTGTGC AGGATCTCTT TAACAGTAGC 
AAGGCTGATC TGTCTGGCAT GTCAGGAGCC AGAGATATTT TTATATCAAA AATTGTCCAC 
AAGTCATTTG TGGAAGTGAA TGAAGAGGGA ACAGAGGCGG CAGCTGCCAC AGCAGGCATC 
GCAACTTTCT GCATGTTGAT GCCCGAAGAA AATTTCACTG CCGACCATCC ATTCCTTTTC 
TTTATTCGGC ATAATTCCTC AGGTAGCATC CTATTCTTGG GGAGATTTTC TTCCCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_109591.1
CDS	247..1386
Translation	MEQLSSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHFNTVEEVHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQHASEDARKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKTVKMMYQKKKFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEKLHEWTKPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSKADLSGMSGARDIFISKIVHKSFVEVNEEGTEAAAATAGIATFCMLMPEENFTADHPFLFFIRHNSSGSILFLGRFSSP

Target ORF information:

RefSeq Version	NM_030666.3
Organism	Homo sapiens(human)
Definition	Homo sapiens serpin family B member 1 (SERPINB1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030666.3

ORF Insert Sequence:

ATGGAGCAGC TGAGCTCAGC AAACACCCGC TTCGCCTTGG ACCTGTTCCT GGCGTTGAGT 
GAGAACAATC CGGCTGGAAA CATCTTCATC TCTCCCTTCA GCATTTCATC TGCTATGGCC 
ATGGTTTTTC TGGGGACCAG AGGTAACACG GCAGCACAGC TGTCCAAGAC TTTCCATTTC 
AACACGGTTG AAGAGGTTCA TTCAAGATTC CAGAGTCTGA ATGCTGATAT CAACAAACGT 
GGAGCGTCTT ATATTCTGAA ACTTGCTAAT AGATTATATG GAGAGAAAAC TTACAATTTC 
CTTCCTGAGT TCTTGGTTTC GACTCAGAAA ACATATGGTG CTGACCTGGC CAGTGTGGAT 
TTTCAGCATG CCTCTGAAGA TGCAAGGAAG ACCATAAACC AGTGGGTCAA AGGACAGACA 
GAAGGAAAAA TTCCGGAACT GTTGGCTTCG GGCATGGTTG ATAACATGAC CAAACTTGTG 
CTAGTAAATG CCATCTATTT CAAGGGAAAC TGGAAGGATA AATTCATGAA AGAAGCCACG 
ACGAATGCAC CATTCAGATT GAATAAGAAA GACAGAAAAA CTGTGAAAAT GATGTATCAG 
AAGAAAAAAT TTGCATATGG CTACATCGAG GACCTTAAGT GCCGTGTGCT GGAACTGCCT 
TACCAAGGCG AGGAGCTCAG CATGGTCATC CTGCTGCCGG ATGACATTGA GGACGAGTCC 
ACGGGCCTGA AGAAGATTGA GGAACAGTTG ACTTTGGAAA AGTTGCATGA GTGGACTAAA 
CCTGAGAATC TCGATTTCAT TGAAGTTAAT GTCAGCTTGC CCAGGTTCAA ACTGGAAGAG 
AGTTACACTC TCAACTCCGA CCTCGCCCGC CTAGGTGTGC AGGATCTCTT TAACAGTAGC 
AAGGCTGATC TGTCTGGCAT GTCAGGAGCC AGAGATATTT TTATATCAAA AATTGTCCAC 
AAGTCATTTG TGGAAGTGAA TGAAGAGGGA ACAGAGGCGG CAGCTGCCAC AGCAGGCATC 
GCAACTTTCT GCATGTTGAT GCCCGAAGAA AATTTCACTG CCGACCATCC ATTCCTTTTC 
TTTATTCGGC ATAATTCCTC AGGTAGCATC CTATTCTTGG GGAGATTTTC TTCCCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SERPINB1 ( XM_011514334.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011512636.1 Homo sapiens serpin family B member 1 (SERPINB1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu14050
Clone ID Related Accession (Same CDS sequence)	NM_030666.4 , NM_030666.3 , XM_011514334.2 , XM_011514334.1 , XM_011514333.1
Accession Version	XM_011514334.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1140bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	leukocyte elastase inhibitor isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011514334.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCAGC TGAGCTCAGC AAACACCCGC TTCGCCTTGG ACCTGTTCCT GGCGTTGAGT 
GAGAACAATC CGGCTGGAAA CATCTTCATC TCTCCCTTCA GCATTTCATC TGCTATGGCC 
ATGGTTTTTC TGGGGACCAG AGGTAACACG GCAGCACAGC TGTCCAAGAC TTTCCATTTC 
AACACGGTTG AAGAGGTTCA TTCAAGATTC CAGAGTCTGA ATGCTGATAT CAACAAACGT 
GGAGCGTCTT ATATTCTGAA ACTTGCTAAT AGATTATATG GAGAGAAAAC TTACAATTTC 
CTTCCTGAGT TCTTGGTTTC GACTCAGAAA ACATATGGTG CTGACCTGGC CAGTGTGGAT 
TTTCAGCATG CCTCTGAAGA TGCAAGGAAG ACCATAAACC AGTGGGTCAA AGGACAGACA 
GAAGGAAAAA TTCCGGAACT GTTGGCTTCG GGCATGGTTG ATAACATGAC CAAACTTGTG 
CTAGTAAATG CCATCTATTT CAAGGGAAAC TGGAAGGATA AATTCATGAA AGAAGCCACG 
ACGAATGCAC CATTCAGATT GAATAAGAAA GACAGAAAAA CTGTGAAAAT GATGTATCAG 
AAGAAAAAAT TTGCATATGG CTACATCGAG GACCTTAAGT GCCGTGTGCT GGAACTGCCT 
TACCAAGGCG AGGAGCTCAG CATGGTCATC CTGCTGCCGG ATGACATTGA GGACGAGTCC 
ACGGGCCTGA AGAAGATTGA GGAACAGTTG ACTTTGGAAA AGTTGCATGA GTGGACTAAA 
CCTGAGAATC TCGATTTCAT TGAAGTTAAT GTCAGCTTGC CCAGGTTCAA ACTGGAAGAG 
AGTTACACTC TCAACTCCGA CCTCGCCCGC CTAGGTGTGC AGGATCTCTT TAACAGTAGC 
AAGGCTGATC TGTCTGGCAT GTCAGGAGCC AGAGATATTT TTATATCAAA AATTGTCCAC 
AAGTCATTTG TGGAAGTGAA TGAAGAGGGA ACAGAGGCGG CAGCTGCCAC AGCAGGCATC 
GCAACTTTCT GCATGTTGAT GCCCGAAGAA AATTTCACTG CCGACCATCC ATTCCTTTTC 
TTTATTCGGC ATAATTCCTC AGGTAGCATC CTATTCTTGG GGAGATTTTC TTCCCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011512636.1
CDS	381..1520
Translation	MEQLSSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHFNTVEEVHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQHASEDARKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKTVKMMYQKKKFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEKLHEWTKPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSKADLSGMSGARDIFISKIVHKSFVEVNEEGTEAAAATAGIATFCMLMPEENFTADHPFLFFIRHNSSGSILFLGRFSSP

Target ORF information:

RefSeq Version	XM_011514334.2
Organism	Homo sapiens(human)
Definition	Homo sapiens serpin family B member 1 (SERPINB1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011514334.2

ORF Insert Sequence:

ATGGAGCAGC TGAGCTCAGC AAACACCCGC TTCGCCTTGG ACCTGTTCCT GGCGTTGAGT 
GAGAACAATC CGGCTGGAAA CATCTTCATC TCTCCCTTCA GCATTTCATC TGCTATGGCC 
ATGGTTTTTC TGGGGACCAG AGGTAACACG GCAGCACAGC TGTCCAAGAC TTTCCATTTC 
AACACGGTTG AAGAGGTTCA TTCAAGATTC CAGAGTCTGA ATGCTGATAT CAACAAACGT 
GGAGCGTCTT ATATTCTGAA ACTTGCTAAT AGATTATATG GAGAGAAAAC TTACAATTTC 
CTTCCTGAGT TCTTGGTTTC GACTCAGAAA ACATATGGTG CTGACCTGGC CAGTGTGGAT 
TTTCAGCATG CCTCTGAAGA TGCAAGGAAG ACCATAAACC AGTGGGTCAA AGGACAGACA 
GAAGGAAAAA TTCCGGAACT GTTGGCTTCG GGCATGGTTG ATAACATGAC CAAACTTGTG 
CTAGTAAATG CCATCTATTT CAAGGGAAAC TGGAAGGATA AATTCATGAA AGAAGCCACG 
ACGAATGCAC CATTCAGATT GAATAAGAAA GACAGAAAAA CTGTGAAAAT GATGTATCAG 
AAGAAAAAAT TTGCATATGG CTACATCGAG GACCTTAAGT GCCGTGTGCT GGAACTGCCT 
TACCAAGGCG AGGAGCTCAG CATGGTCATC CTGCTGCCGG ATGACATTGA GGACGAGTCC 
ACGGGCCTGA AGAAGATTGA GGAACAGTTG ACTTTGGAAA AGTTGCATGA GTGGACTAAA 
CCTGAGAATC TCGATTTCAT TGAAGTTAAT GTCAGCTTGC CCAGGTTCAA ACTGGAAGAG 
AGTTACACTC TCAACTCCGA CCTCGCCCGC CTAGGTGTGC AGGATCTCTT TAACAGTAGC 
AAGGCTGATC TGTCTGGCAT GTCAGGAGCC AGAGATATTT TTATATCAAA AATTGTCCAC 
AAGTCATTTG TGGAAGTGAA TGAAGAGGGA ACAGAGGCGG CAGCTGCCAC AGCAGGCATC 
GCAACTTTCT GCATGTTGAT GCCCGAAGAA AATTTCACTG CCGACCATCC ATTCCTTTTC 
TTTATTCGGC ATAATTCCTC AGGTAGCATC CTATTCTTGG GGAGATTTTC TTCCCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SERPINB1 ( XM_011514334.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011512636.1 Homo sapiens serpin peptidase inhibitor, clade B (ovalbumin), member 1 (SERPINB1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu14050
Clone ID Related Accession (Same CDS sequence)	NM_030666.4 , NM_030666.3 , XM_011514334.2 , XM_011514334.1 , XM_011514333.1
Accession Version	XM_011514334.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1140bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1426003200000
Organism	Homo sapiens(Human)
Product	leukocyte elastase inhibitor isoform X1
Comment

ATGGAGCAGC TGAGCTCAGC AAACACCCGC TTCGCCTTGG ACCTGTTCCT GGCGTTGAGT 
GAGAACAATC CGGCTGGAAA CATCTTCATC TCTCCCTTCA GCATTTCATC TGCTATGGCC 
ATGGTTTTTC TGGGGACCAG AGGTAACACG GCAGCACAGC TGTCCAAGAC TTTCCATTTC 
AACACGGTTG AAGAGGTTCA TTCAAGATTC CAGAGTCTGA ATGCTGATAT CAACAAACGT 
GGAGCGTCTT ATATTCTGAA ACTTGCTAAT AGATTATATG GAGAGAAAAC TTACAATTTC 
CTTCCTGAGT TCTTGGTTTC GACTCAGAAA ACATATGGTG CTGACCTGGC CAGTGTGGAT 
TTTCAGCATG CCTCTGAAGA TGCAAGGAAG ACCATAAACC AGTGGGTCAA AGGACAGACA 
GAAGGAAAAA TTCCGGAACT GTTGGCTTCG GGCATGGTTG ATAACATGAC CAAACTTGTG 
CTAGTAAATG CCATCTATTT CAAGGGAAAC TGGAAGGATA AATTCATGAA AGAAGCCACG 
ACGAATGCAC CATTCAGATT GAATAAGAAA GACAGAAAAA CTGTGAAAAT GATGTATCAG 
AAGAAAAAAT TTGCATATGG CTACATCGAG GACCTTAAGT GCCGTGTGCT GGAACTGCCT 
TACCAAGGCG AGGAGCTCAG CATGGTCATC CTGCTGCCGG ATGACATTGA GGACGAGTCC 
ACGGGCCTGA AGAAGATTGA GGAACAGTTG ACTTTGGAAA AGTTGCATGA GTGGACTAAA 
CCTGAGAATC TCGATTTCAT TGAAGTTAAT GTCAGCTTGC CCAGGTTCAA ACTGGAAGAG 
AGTTACACTC TCAACTCCGA CCTCGCCCGC CTAGGTGTGC AGGATCTCTT TAACAGTAGC 
AAGGCTGATC TGTCTGGCAT GTCAGGAGCC AGAGATATTT TTATATCAAA AATTGTCCAC 
AAGTCATTTG TGGAAGTGAA TGAAGAGGGA ACAGAGGCGG CAGCTGCCAC AGCAGGCATC 
GCAACTTTCT GCATGTTGAT GCCCGAAGAA AATTTCACTG CCGACCATCC ATTCCTTTTC 
TTTATTCGGC ATAATTCCTC AGGTAGCATC CTATTCTTGG GGAGATTTTC TTCCCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011512636.1
Translation	MEQLSSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHFNTVEEVHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQHASEDARKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKTVKMMYQKKKFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEKLHEWTKPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSKADLSGMSGARDIFISKIVHKSFVEVNEEGTEAAAATAGIATFCMLMPEENFTADHPFLFFIRHNSSGSILFLGRFSSP

Target ORF information:

RefSeq Version	XM_011514334.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens serpin peptidase inhibitor, clade B (ovalbumin), member 1 (SERPINB1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011514334.1

ORF Insert Sequence:

ATGGAGCAGC TGAGCTCAGC AAACACCCGC TTCGCCTTGG ACCTGTTCCT GGCGTTGAGT 
GAGAACAATC CGGCTGGAAA CATCTTCATC TCTCCCTTCA GCATTTCATC TGCTATGGCC 
ATGGTTTTTC TGGGGACCAG AGGTAACACG GCAGCACAGC TGTCCAAGAC TTTCCATTTC 
AACACGGTTG AAGAGGTTCA TTCAAGATTC CAGAGTCTGA ATGCTGATAT CAACAAACGT 
GGAGCGTCTT ATATTCTGAA ACTTGCTAAT AGATTATATG GAGAGAAAAC TTACAATTTC 
CTTCCTGAGT TCTTGGTTTC GACTCAGAAA ACATATGGTG CTGACCTGGC CAGTGTGGAT 
TTTCAGCATG CCTCTGAAGA TGCAAGGAAG ACCATAAACC AGTGGGTCAA AGGACAGACA 
GAAGGAAAAA TTCCGGAACT GTTGGCTTCG GGCATGGTTG ATAACATGAC CAAACTTGTG 
CTAGTAAATG CCATCTATTT CAAGGGAAAC TGGAAGGATA AATTCATGAA AGAAGCCACG 
ACGAATGCAC CATTCAGATT GAATAAGAAA GACAGAAAAA CTGTGAAAAT GATGTATCAG 
AAGAAAAAAT TTGCATATGG CTACATCGAG GACCTTAAGT GCCGTGTGCT GGAACTGCCT 
TACCAAGGCG AGGAGCTCAG CATGGTCATC CTGCTGCCGG ATGACATTGA GGACGAGTCC 
ACGGGCCTGA AGAAGATTGA GGAACAGTTG ACTTTGGAAA AGTTGCATGA GTGGACTAAA 
CCTGAGAATC TCGATTTCAT TGAAGTTAAT GTCAGCTTGC CCAGGTTCAA ACTGGAAGAG 
AGTTACACTC TCAACTCCGA CCTCGCCCGC CTAGGTGTGC AGGATCTCTT TAACAGTAGC 
AAGGCTGATC TGTCTGGCAT GTCAGGAGCC AGAGATATTT TTATATCAAA AATTGTCCAC 
AAGTCATTTG TGGAAGTGAA TGAAGAGGGA ACAGAGGCGG CAGCTGCCAC AGCAGGCATC 
GCAACTTTCT GCATGTTGAT GCCCGAAGAA AATTTCACTG CCGACCATCC ATTCCTTTTC 
TTTATTCGGC ATAATTCCTC AGGTAGCATC CTATTCTTGG GGAGATTTTC TTCCCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SERPINB1 ( XM_011514333.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011512635.1 Homo sapiens serpin family B member 1 (SERPINB1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu14050
Clone ID Related Accession (Same CDS sequence)	NM_030666.4 , NM_030666.3 , XM_011514334.2 , XM_011514334.1 , XM_011514333.1
Accession Version	XM_011514333.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1140bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	leukocyte elastase inhibitor isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCAGC TGAGCTCAGC AAACACCCGC TTCGCCTTGG ACCTGTTCCT GGCGTTGAGT 
GAGAACAATC CGGCTGGAAA CATCTTCATC TCTCCCTTCA GCATTTCATC TGCTATGGCC 
ATGGTTTTTC TGGGGACCAG AGGTAACACG GCAGCACAGC TGTCCAAGAC TTTCCATTTC 
AACACGGTTG AAGAGGTTCA TTCAAGATTC CAGAGTCTGA ATGCTGATAT CAACAAACGT 
GGAGCGTCTT ATATTCTGAA ACTTGCTAAT AGATTATATG GAGAGAAAAC TTACAATTTC 
CTTCCTGAGT TCTTGGTTTC GACTCAGAAA ACATATGGTG CTGACCTGGC CAGTGTGGAT 
TTTCAGCATG CCTCTGAAGA TGCAAGGAAG ACCATAAACC AGTGGGTCAA AGGACAGACA 
GAAGGAAAAA TTCCGGAACT GTTGGCTTCG GGCATGGTTG ATAACATGAC CAAACTTGTG 
CTAGTAAATG CCATCTATTT CAAGGGAAAC TGGAAGGATA AATTCATGAA AGAAGCCACG 
ACGAATGCAC CATTCAGATT GAATAAGAAA GACAGAAAAA CTGTGAAAAT GATGTATCAG 
AAGAAAAAAT TTGCATATGG CTACATCGAG GACCTTAAGT GCCGTGTGCT GGAACTGCCT 
TACCAAGGCG AGGAGCTCAG CATGGTCATC CTGCTGCCGG ATGACATTGA GGACGAGTCC 
ACGGGCCTGA AGAAGATTGA GGAACAGTTG ACTTTGGAAA AGTTGCATGA GTGGACTAAA 
CCTGAGAATC TCGATTTCAT TGAAGTTAAT GTCAGCTTGC CCAGGTTCAA ACTGGAAGAG 
AGTTACACTC TCAACTCCGA CCTCGCCCGC CTAGGTGTGC AGGATCTCTT TAACAGTAGC 
AAGGCTGATC TGTCTGGCAT GTCAGGAGCC AGAGATATTT TTATATCAAA AATTGTCCAC 
AAGTCATTTG TGGAAGTGAA TGAAGAGGGA ACAGAGGCGG CAGCTGCCAC AGCAGGCATC 
GCAACTTTCT GCATGTTGAT GCCCGAAGAA AATTTCACTG CCGACCATCC ATTCCTTTTC 
TTTATTCGGC ATAATTCCTC AGGTAGCATC CTATTCTTGG GGAGATTTTC TTCCCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011512635.1
CDS	470..1609
Translation	MEQLSSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHFNTVEEVHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQHASEDARKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKTVKMMYQKKKFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEKLHEWTKPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSKADLSGMSGARDIFISKIVHKSFVEVNEEGTEAAAATAGIATFCMLMPEENFTADHPFLFFIRHNSSGSILFLGRFSSP

Target ORF information:

RefSeq Version	XM_011514333.1
Organism	Homo sapiens(human)
Definition	Homo sapiens serpin family B member 1 (SERPINB1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011514333.1

ORF Insert Sequence:

ATGGAGCAGC TGAGCTCAGC AAACACCCGC TTCGCCTTGG ACCTGTTCCT GGCGTTGAGT 
GAGAACAATC CGGCTGGAAA CATCTTCATC TCTCCCTTCA GCATTTCATC TGCTATGGCC 
ATGGTTTTTC TGGGGACCAG AGGTAACACG GCAGCACAGC TGTCCAAGAC TTTCCATTTC 
AACACGGTTG AAGAGGTTCA TTCAAGATTC CAGAGTCTGA ATGCTGATAT CAACAAACGT 
GGAGCGTCTT ATATTCTGAA ACTTGCTAAT AGATTATATG GAGAGAAAAC TTACAATTTC 
CTTCCTGAGT TCTTGGTTTC GACTCAGAAA ACATATGGTG CTGACCTGGC CAGTGTGGAT 
TTTCAGCATG CCTCTGAAGA TGCAAGGAAG ACCATAAACC AGTGGGTCAA AGGACAGACA 
GAAGGAAAAA TTCCGGAACT GTTGGCTTCG GGCATGGTTG ATAACATGAC CAAACTTGTG 
CTAGTAAATG CCATCTATTT CAAGGGAAAC TGGAAGGATA AATTCATGAA AGAAGCCACG 
ACGAATGCAC CATTCAGATT GAATAAGAAA GACAGAAAAA CTGTGAAAAT GATGTATCAG 
AAGAAAAAAT TTGCATATGG CTACATCGAG GACCTTAAGT GCCGTGTGCT GGAACTGCCT 
TACCAAGGCG AGGAGCTCAG CATGGTCATC CTGCTGCCGG ATGACATTGA GGACGAGTCC 
ACGGGCCTGA AGAAGATTGA GGAACAGTTG ACTTTGGAAA AGTTGCATGA GTGGACTAAA 
CCTGAGAATC TCGATTTCAT TGAAGTTAAT GTCAGCTTGC CCAGGTTCAA ACTGGAAGAG 
AGTTACACTC TCAACTCCGA CCTCGCCCGC CTAGGTGTGC AGGATCTCTT TAACAGTAGC 
AAGGCTGATC TGTCTGGCAT GTCAGGAGCC AGAGATATTT TTATATCAAA AATTGTCCAC 
AAGTCATTTG TGGAAGTGAA TGAAGAGGGA ACAGAGGCGG CAGCTGCCAC AGCAGGCATC 
GCAACTTTCT GCATGTTGAT GCCCGAAGAA AATTTCACTG CCGACCATCC ATTCCTTTTC 
TTTATTCGGC ATAATTCCTC AGGTAGCATC CTATTCTTGG GGAGATTTTC TTCCCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SERPINB1-mediated checkpoint of inflammatory caspase activation.
Nature immunology20(3)276-287(2019 03)
Choi YJ,Kim S,Choi Y,Nielsen TB,Yan J,Lu A,Ruan J,Lee HR,Wu H,Spellberg B,Jung JU

Sex-specific genetic predictors of Alzheimer's disease biomarkers.
Acta neuropathologica136(6)857-872(2018 12)
Deming Y,Dumitrescu L,Barnes LL,Thambisetty M,Kunkle B,Gifford KA,Bush WS,Chibnik LB,Mukherjee S,De Jager PL,Kukull W,Huentelman M,Crane PK,Resnick SM,Keene CD,Montine TJ,Schellenberg GD,Haines JL,Zetterberg H,Blennow K,Larson EB,Johnson SC,Albert M,Moghekar A,Del Aguila JL,Fernandez MV,Budde J,Hassenstab J,Fagan AM,Riemenschneider M,Petersen RC,Minthon L,Chao MJ,Van Deerlin VM,Lee VM,Shaw LM,Trojanowski JQ,Peskind ER,Li G,Davis LK,Sealock JM,Cox NJ,,,Goate AM,Bennett DA,Schneider JA,Jefferson AL,Cruchaga C,Hohman TJ

Proteomic Profiling and Differential Messenger RNA Expression Correlate HSP27 and Serpin Family B Member 1 to Apical Periodontitis Outcomes.
Journal of endodontics43(9)1486-1493(2017 Sep)
Cavalla F,Biguetti C,Jain S,Johnson C,Letra A,Garlet GP,Silva RM

SERPINB1 ameliorates acute lung injury in liver transplantation through ERK1/2-mediated STAT3-dependent HO-1 induction.
Free radical biology & medicine108542-553(2017 07)
Yao W,Li H,Luo G,Li X,Chen C,Yuan D,Chi X,Xia Z,Hei Z

Human gingiva transcriptome during wound healing.
Journal of clinical periodontology44(4)394-402(2017 Apr)
Wang Y,Tatakis DN

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SERPINB1 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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