DLST cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DLST
Entrez Gene ID	1743
Full Name	dihydrolipoamide S-succinyltransferase
Synonyms	DLTS
General protein information	Preferred Names dihydrolipoamide S-succinyltransferase Names dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial E2K OGDC-E2 dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q24.3
Summary	This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011].
Disorder MIM:	126063

mRNA and Protein(s)

mRNA	Protein	Name
NM_001244883.2	NP_001231812.1	dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 2 precursor
NM_001933.5	NP_001924.2	dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 1 precursor
NM_001244883.1	NP_001231812.1	dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 2 precursor
NM_001933.4	NP_001924.2	dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	DLST	NP_001924.2
Mus musculus (house mouse)	Dlst	NP_084501.1
Gallus gallus (chicken)	DLST	NP_001012919.1
Danio rerio (zebrafish)	dlst	NP_958895.1
Arabidopsis thaliana (thale cress)	AT5G55070	NP_200318.1
Eremothecium gossypii	AGOS_AGL200W	NP_986467.1
Neurospora crassa	NCU02438	XP_959443.1
Bos taurus (cattle)	DLST	NP_001068750.1
Caenorhabditis elegans (roundworm)	dlst-1	NP_504700.2
Xenopus tropicalis (tropical clawed frog)	dlst	NP_001004929.1
Magnaporthe oryzae (rice blast fungus)	MGG_03149	XP_003716846.1
Arabidopsis thaliana (thale cress)	AT4G26910	NP_567761.1
Canis lupus familiaris (dog)	DLST	XP_003639252.1
Pan troglodytes (chimpanzee)	DLST	XP_510068.2
Macaca mulatta (Rhesus monkey)	DLST	XP_001095138.1
Schizosaccharomyces pombe (fission yeast)	kgd2	NP_596331.1
Oryza sativa (rice)	Os04g0394200	NP_001052652.1
Rattus norvegicus (Norway rat)	Dlst	NP_001006982.2
Saccharomyces cerevisiae (baker's yeast)	KGD2	NP_010432.3
Kluyveromyces lactis	KLLA0D16522g	XP_453789.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004055	XP_309608.4

Gene Ontology
Bibliography

Related articles in PubMed

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.
Malty RH, Aoki H, Kumar A, Phanse S, Amin S, Zhang Q, Minic Z, Goebels F, Musso G, Wu Z, Abou-Tok H, Meyer M, Deineko V, Kassir S, Sidhu V, Jessulat M, Scott NE, Xiong X, Vlasblom J, Prasad B, Foster LJ, Alberio T, Garavaglia B, Yu H, Bader GD, Nakamura K, Parkinson J, Babu M
Cell systems5(6)564-577.e12(2017 12)

KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase.
Wang Y, Guo YR, Liu K, Yin Z, Liu R, Xia Y, Tan L, Yang P, Lee JH, Li XJ, Hawke D, Zheng Y, Qian X, Lyu J, He J, Xing D, Tao YJ, Lu Z
Nature552(7684)273-277(2017 12)

The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis.
Anderson NM, Li D, Peng HL, Laroche FJ, Mansour MR, Gjini E, Aioub M, Helman DJ, Roderick JE, Cheng T, Harrold I, Samaha Y, Meng L, Amsterdam A, Neuberg DS, Denton TT, Sanda T, Kelliher MA, Singh A, Look AT, Feng H
Leukemia30(6)1365-74(2016 06)

The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation.
Kiss G, Konrad C, Doczi J, Starkov AA, Kawamata H, Manfredi G, Zhang SF, Gibson GE, Beal MF, Adam-Vizi V, Chinopoulos C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology27(6)2392-406(2013 Jun)

Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study.
Lee Y, Yoon KA, Joo J, Lee D, Bae K, Han JY, Lee JS
Carcinogenesis34(2)307-13(2013 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following DLST gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DLST cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu55825	NM_001244883.2 Latest version!	Homo sapiens dihydrolipoamide S-succinyltransferase (DLST), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu19679	NM_001933.5 Latest version!	Homo sapiens dihydrolipoamide S-succinyltransferase (DLST), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$258.30 $369.00
View Old Accession Versions >>
OHu55825	NM_001244883.1	Homo sapiens dihydrolipoamide S-succinyltransferase (DLST), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu19679	NM_001933.4	Homo sapiens dihydrolipoamide S-succinyltransferase (DLST), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$258.30 $369.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DLST ( NM_001244883.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001231812.1 Homo sapiens dihydrolipoamide S-succinyltransferase (DLST), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu55825
Clone ID Related Accession (Same CDS sequence)	NM_001244883.2 , NM_001244883.1
Accession Version	NM_001244883.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569600000000
Organism	Homo sapiens(human)
Product	dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC338747.1, AK300396.1, DA995927.1 and AC006530.4. On Jun 1, 2019 this sequence version replaced NM_001244883.1. Transcript Variant: This variant (2) differs at the 3' end compared to variant 1. This results in a shorter isoform (2) with a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK300396.1, HY180550.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGCTGTCCC GATCCCGCTG TGTGTCTCGG GCGTTCAGCC GCTCGCTCTC CGCCTTCCAG 
AAGGGGAACT GCCCTCTAGG GAGACGTTCC CTGCCTGGGG TCTCCTTATG CCAGGGACCA 
GGTTACCCTA ACAGCAGGAA GGTTGTCATT AACAACAGTG TCTTCAGTGT TCGCTTTTTC 
AGAACTACAG CTGTATGCAA GGATGACTTG GTTACAGTCA AAACCCCAGC GTTTGCAGAA 
TCTGTCACAG AGGGAGATGT CAGGTGGGAG AAAGCTGTTG GAGACACAGT TGCAGAAGAT 
GAAGTGGTTT GTGAGATTGA AACTGACAAG ACATCTGTGC AGGTTCCATC ACCAGCAAAT 
GGCGTGATTG AAGCTCTTTT GGTACCTGAT GGGGGAAAAG TCGAAGGAGG CACTCCACTT 
TTCACACTCA GGAAAACTGG TGGTAAAGAA GTTCTCCTGG TGGTCAAGGT CTCCAGTGTT 
CCCTCTTGGG ATTGGGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001231812.1
CDS	39..539
Translation	MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCQGPGYPNSRKVVINNSVFSVRFFRTTAVCKDDLVTVKTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTSVQVPSPANGVIEALLVPDGGKVEGGTPLFTLRKTGGKEVLLVVKVSSVPSWDWD

Target ORF information:

RefSeq Version	NM_001244883.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dihydrolipoamide S-succinyltransferase (DLST), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001244883.2

ORF Insert Sequence:

ATGCTGTCCC GATCCCGCTG TGTGTCTCGG GCGTTCAGCC GCTCGCTCTC CGCCTTCCAG 
AAGGGGAACT GCCCTCTAGG GAGACGTTCC CTGCCTGGGG TCTCCTTATG CCAGGGACCA 
GGTTACCCTA ACAGCAGGAA GGTTGTCATT AACAACAGTG TCTTCAGTGT TCGCTTTTTC 
AGAACTACAG CTGTATGCAA GGATGACTTG GTTACAGTCA AAACCCCAGC GTTTGCAGAA 
TCTGTCACAG AGGGAGATGT CAGGTGGGAG AAAGCTGTTG GAGACACAGT TGCAGAAGAT 
GAAGTGGTTT GTGAGATTGA AACTGACAAG ACATCTGTGC AGGTTCCATC ACCAGCAAAT 
GGCGTGATTG AAGCTCTTTT GGTACCTGAT GGGGGAAAAG TCGAAGGAGG CACTCCACTT 
TTCACACTCA GGAAAACTGG TGGTAAAGAA GTTCTCCTGG TGGTCAAGGT CTCCAGTGTT 
CCCTCTTGGG ATTGGGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DLST ( NM_001244883.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001231812.1 Homo sapiens dihydrolipoamide S-succinyltransferase (DLST), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu55825
Clone ID Related Accession (Same CDS sequence)	NM_001244883.2 , NM_001244883.1
Accession Version	NM_001244883.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550764800000
Organism	Homo sapiens(human)
Product	dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC338747.1, AK300396.1 and DA995927.1. Transcript Variant: This variant (2) differs at the 3' end compared to variant 1. This results in a shorter isoform (2) with a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK300396.1, CN422508.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGCTGTCCC GATCCCGCTG TGTGTCTCGG GCGTTCAGCC GCTCGCTCTC CGCCTTCCAG 
AAGGGGAACT GCCCTCTAGG GAGACGTTCC CTGCCTGGGG TCTCCTTATG CCAGGGACCA 
GGTTACCCTA ACAGCAGGAA GGTTGTCATT AACAACAGTG TCTTCAGTGT TCGCTTTTTC 
AGAACTACAG CTGTATGCAA GGATGACTTG GTTACAGTCA AAACCCCAGC GTTTGCAGAA 
TCTGTCACAG AGGGAGATGT CAGGTGGGAG AAAGCTGTTG GAGACACAGT TGCAGAAGAT 
GAAGTGGTTT GTGAGATTGA AACTGACAAG ACATCTGTGC AGGTTCCATC ACCAGCAAAT 
GGCGTGATTG AAGCTCTTTT GGTACCTGAT GGGGGAAAAG TCGAAGGAGG CACTCCACTT 
TTCACACTCA GGAAAACTGG TGGTAAAGAA GTTCTCCTGG TGGTCAAGGT CTCCAGTGTT 
CCCTCTTGGG ATTGGGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001231812.1
CDS	64..564
Translation	MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCQGPGYPNSRKVVINNSVFSVRFFRTTAVCKDDLVTVKTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTSVQVPSPANGVIEALLVPDGGKVEGGTPLFTLRKTGGKEVLLVVKVSSVPSWDWD

Target ORF information:

RefSeq Version	NM_001244883.1
Organism	Homo sapiens(human)
Definition	Homo sapiens dihydrolipoamide S-succinyltransferase (DLST), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001244883.1

ORF Insert Sequence:

ATGCTGTCCC GATCCCGCTG TGTGTCTCGG GCGTTCAGCC GCTCGCTCTC CGCCTTCCAG 
AAGGGGAACT GCCCTCTAGG GAGACGTTCC CTGCCTGGGG TCTCCTTATG CCAGGGACCA 
GGTTACCCTA ACAGCAGGAA GGTTGTCATT AACAACAGTG TCTTCAGTGT TCGCTTTTTC 
AGAACTACAG CTGTATGCAA GGATGACTTG GTTACAGTCA AAACCCCAGC GTTTGCAGAA 
TCTGTCACAG AGGGAGATGT CAGGTGGGAG AAAGCTGTTG GAGACACAGT TGCAGAAGAT 
GAAGTGGTTT GTGAGATTGA AACTGACAAG ACATCTGTGC AGGTTCCATC ACCAGCAAAT 
GGCGTGATTG AAGCTCTTTT GGTACCTGAT GGGGGAAAAG TCGAAGGAGG CACTCCACTT 
TTCACACTCA GGAAAACTGG TGGTAAAGAA GTTCTCCTGG TGGTCAAGGT CTCCAGTGTT 
CCCTCTTGGG ATTGGGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DLST ( NM_001933.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001924.2 Homo sapiens dihydrolipoamide S-succinyltransferase (DLST), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19679
Clone ID Related Accession (Same CDS sequence)	NM_001933.5 , NM_001933.4
Accession Version	NM_001933.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1362bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569254400000
Organism	Homo sapiens(human)
Product	dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK289414.1, CX163292.1, CN422511.1, BM929953.1 and AI087261.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001933.4. Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000302.2, SRR3476690.920610.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000334220.9/ ENSP00000335304.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGTCCC GATCCCGCTG TGTGTCTCGG GCGTTCAGCC GCTCGCTCTC CGCCTTCCAG 
AAGGGGAACT GCCCTCTAGG GAGACGTTCC CTGCCTGGGG TCTCCTTATG CCAGGGACCA 
GGTTACCCTA ACAGCAGGAA GGTTGTCATT AACAACAGTG TCTTCAGTGT TCGCTTTTTC 
AGAACTACAG CTGTATGCAA GGATGACTTG GTTACAGTCA AAACCCCAGC GTTTGCAGAA 
TCTGTCACAG AGGGAGATGT CAGGTGGGAG AAAGCTGTTG GAGACACAGT TGCAGAAGAT 
GAAGTGGTTT GTGAGATTGA AACTGACAAG ACATCTGTGC AGGTTCCATC ACCAGCAAAT 
GGCGTGATTG AAGCTCTTTT GGTACCTGAT GGGGGAAAAG TCGAAGGAGG CACTCCACTT 
TTCACACTCA GGAAAACTGG TGCTGCTCCT GCTAAGGCCA AGCCGGCTGA AGCTCCTGCT 
GCTGCAGCCC CAAAAGCAGA ACCTACAGCA GCGGCAGTTC CTCCCCCTGC AGCACCCATA 
CCCACTCAGA TGCCACCGGT GCCCTCGCCC TCACAGCCTC CTTCTGGCAA ACCTGTGTCT 
GCAGTAAAAC CCACTGTTGC CCCACCACTA GCTGAGCCAG GAGCTGGCAA AGGTCTGCGT 
TCAGAACATC GGGAGAAAAT GAACAGGATG CGGCAGCGCA TTGCTCAGCG TCTGAAGGAG 
GCCCAGAATA CATGTGCAAT GCTGACAACT TTTAATGAGA TTGACATGAG TAACATCCAG 
GAGATGAGGG CTCGGCACAA AGAGGCTTTT TTGAAGAAAC ATAACCTCAA ACTAGGCTTC 
ATGTCGGCAT TTGTGAAGGC CTCAGCCTTT GCCTTGCAGG AACAGCCTGT TGTAAATGCA 
GTGATTGACG ACACAACCAA AGAGGTGGTG TATAGGGATT ATATTGACAT CAGTGTTGCA 
GTGGCCACCC CACGGGGTCT GGTGGTTCCA GTCATCAGGA ATGTGGAAGC TATGAATTTT 
GCAGATATTG AACGGACCAT CACTGAACTG GGAGAGAAGG CCCGAAAGAA TGAACTTGCC 
ATTGAAGATA TGGATGGCGG TACCTTCACC ATTAGCAATG GAGGCGTTTT TGGCTCGCTC 
TTTGGAACAC CCATTATCAA CCCCCCTCAG TCTGCCATCC TGGGGATGCA TGGCATCTTT 
GACAGGCCAG TGGCTATAGG AGGCAAGGTA GAGGTGCGGC CCATGATGTA CGTGGCACTG 
ACCTATGATC ACCGGCTGAT TGATGGCAGA GAGGCTGTGA CTTTCCTCCG CAAAATCAAG 
GCAGCGGTAG AGGATCCCAG AGTCCTCCTC CTGGATCTTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001924.2
CDS	39..1400
Translation	MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCQGPGYPNSRKVVINNSVFSVRFFRTTAVCKDDLVTVKTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTSVQVPSPANGVIEALLVPDGGKVEGGTPLFTLRKTGAAPAKAKPAEAPAAAAPKAEPTAAAVPPPAAPIPTQMPPVPSPSQPPSGKPVSAVKPTVAPPLAEPGAGKGLRSEHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEIDMSNIQEMRARHKEAFLKKHNLKLGFMSAFVKASAFALQEQPVVNAVIDDTTKEVVYRDYIDISVAVATPRGLVVPVIRNVEAMNFADIERTITELGEKARKNELAIEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHGIFDRPVAIGGKVEVRPMMYVALTYDHRLIDGREAVTFLRKIKAAVEDPRVLLLDL

Target ORF information:

RefSeq Version	NM_001933.5
Organism	Homo sapiens(human)
Definition	Homo sapiens dihydrolipoamide S-succinyltransferase (DLST), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001933.5

ORF Insert Sequence:

ATGCTGTCCC GATCCCGCTG TGTGTCTCGG GCGTTCAGCC GCTCGCTCTC CGCCTTCCAG 
AAGGGGAACT GCCCTCTAGG GAGACGTTCC CTGCCTGGGG TCTCCTTATG CCAGGGACCA 
GGTTACCCTA ACAGCAGGAA GGTTGTCATT AACAACAGTG TCTTCAGTGT TCGCTTTTTC 
AGAACTACAG CTGTATGCAA GGATGACTTG GTTACAGTCA AAACCCCAGC GTTTGCAGAA 
TCTGTCACAG AGGGAGATGT CAGGTGGGAG AAAGCTGTTG GAGACACAGT TGCAGAAGAT 
GAAGTGGTTT GTGAGATTGA AACTGACAAG ACATCTGTGC AGGTTCCATC ACCAGCAAAT 
GGCGTGATTG AAGCTCTTTT GGTACCTGAT GGGGGAAAAG TCGAAGGAGG CACTCCACTT 
TTCACACTCA GGAAAACTGG TGCTGCTCCT GCTAAGGCCA AGCCGGCTGA AGCTCCTGCT 
GCTGCAGCCC CAAAAGCAGA ACCTACAGCA GCGGCAGTTC CTCCCCCTGC AGCACCCATA 
CCCACTCAGA TGCCACCGGT GCCCTCGCCC TCACAGCCTC CTTCTGGCAA ACCTGTGTCT 
GCAGTAAAAC CCACTGTTGC CCCACCACTA GCTGAGCCAG GAGCTGGCAA AGGTCTGCGT 
TCAGAACATC GGGAGAAAAT GAACAGGATG CGGCAGCGCA TTGCTCAGCG TCTGAAGGAG 
GCCCAGAATA CATGTGCAAT GCTGACAACT TTTAATGAGA TTGACATGAG TAACATCCAG 
GAGATGAGGG CTCGGCACAA AGAGGCTTTT TTGAAGAAAC ATAACCTCAA ACTAGGCTTC 
ATGTCGGCAT TTGTGAAGGC CTCAGCCTTT GCCTTGCAGG AACAGCCTGT TGTAAATGCA 
GTGATTGACG ACACAACCAA AGAGGTGGTG TATAGGGATT ATATTGACAT CAGTGTTGCA 
GTGGCCACCC CACGGGGTCT GGTGGTTCCA GTCATCAGGA ATGTGGAAGC TATGAATTTT 
GCAGATATTG AACGGACCAT CACTGAACTG GGAGAGAAGG CCCGAAAGAA TGAACTTGCC 
ATTGAAGATA TGGATGGCGG TACCTTCACC ATTAGCAATG GAGGCGTTTT TGGCTCGCTC 
TTTGGAACAC CCATTATCAA CCCCCCTCAG TCTGCCATCC TGGGGATGCA TGGCATCTTT 
GACAGGCCAG TGGCTATAGG AGGCAAGGTA GAGGTGCGGC CCATGATGTA CGTGGCACTG 
ACCTATGATC ACCGGCTGAT TGATGGCAGA GAGGCTGTGA CTTTCCTCCG CAAAATCAAG 
GCAGCGGTAG AGGATCCCAG AGTCCTCCTC CTGGATCTTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DLST ( NM_001933.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001924.2 Homo sapiens dihydrolipoamide S-succinyltransferase (DLST), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19679
Clone ID Related Accession (Same CDS sequence)	NM_001933.5 , NM_001933.4
Accession Version	NM_001933.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1362bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1504886400000
Organism	Homo sapiens(human)
Product	dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC338747.1, AK289414.1, CX163292.1, CN422511.1, BM929953.1, AI087261.1 and AA101667.1. This sequence is a reference standard in the RefSeqGene project. On Jul 23, 2009 this sequence version replaced NM_001933.3. Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000302.2, D16373.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGTCCC GATCCCGCTG TGTGTCTCGG GCGTTCAGCC GCTCGCTCTC CGCCTTCCAG 
AAGGGGAACT GCCCTCTAGG GAGACGTTCC CTGCCTGGGG TCTCCTTATG CCAGGGACCA 
GGTTACCCTA ACAGCAGGAA GGTTGTCATT AACAACAGTG TCTTCAGTGT TCGCTTTTTC 
AGAACTACAG CTGTATGCAA GGATGACTTG GTTACAGTCA AAACCCCAGC GTTTGCAGAA 
TCTGTCACAG AGGGAGATGT CAGGTGGGAG AAAGCTGTTG GAGACACAGT TGCAGAAGAT 
GAAGTGGTTT GTGAGATTGA AACTGACAAG ACATCTGTGC AGGTTCCATC ACCAGCAAAT 
GGCGTGATTG AAGCTCTTTT GGTACCTGAT GGGGGAAAAG TCGAAGGAGG CACTCCACTT 
TTCACACTCA GGAAAACTGG TGCTGCTCCT GCTAAGGCCA AGCCGGCTGA AGCTCCTGCT 
GCTGCAGCCC CAAAAGCAGA ACCTACAGCA GCGGCAGTTC CTCCCCCTGC AGCACCCATA 
CCCACTCAGA TGCCACCGGT GCCCTCGCCC TCACAGCCTC CTTCTGGCAA ACCTGTGTCT 
GCAGTAAAAC CCACTGTTGC CCCACCACTA GCTGAGCCAG GAGCTGGCAA AGGTCTGCGT 
TCAGAACATC GGGAGAAAAT GAACAGGATG CGGCAGCGCA TTGCTCAGCG TCTGAAGGAG 
GCCCAGAATA CATGTGCAAT GCTGACAACT TTTAATGAGA TTGACATGAG TAACATCCAG 
GAGATGAGGG CTCGGCACAA AGAGGCTTTT TTGAAGAAAC ATAACCTCAA ACTAGGCTTC 
ATGTCGGCAT TTGTGAAGGC CTCAGCCTTT GCCTTGCAGG AACAGCCTGT TGTAAATGCA 
GTGATTGACG ACACAACCAA AGAGGTGGTG TATAGGGATT ATATTGACAT CAGTGTTGCA 
GTGGCCACCC CACGGGGTCT GGTGGTTCCA GTCATCAGGA ATGTGGAAGC TATGAATTTT 
GCAGATATTG AACGGACCAT CACTGAACTG GGAGAGAAGG CCCGAAAGAA TGAACTTGCC 
ATTGAAGATA TGGATGGCGG TACCTTCACC ATTAGCAATG GAGGCGTTTT TGGCTCGCTC 
TTTGGAACAC CCATTATCAA CCCCCCTCAG TCTGCCATCC TGGGGATGCA TGGCATCTTT 
GACAGGCCAG TGGCTATAGG AGGCAAGGTA GAGGTGCGGC CCATGATGTA CGTGGCACTG 
ACCTATGATC ACCGGCTGAT TGATGGCAGA GAGGCTGTGA CTTTCCTCCG CAAAATCAAG 
GCAGCGGTAG AGGATCCCAG AGTCCTCCTC CTGGATCTTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001924.2
CDS	64..1425
Translation	MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCQGPGYPNSRKVVINNSVFSVRFFRTTAVCKDDLVTVKTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTSVQVPSPANGVIEALLVPDGGKVEGGTPLFTLRKTGAAPAKAKPAEAPAAAAPKAEPTAAAVPPPAAPIPTQMPPVPSPSQPPSGKPVSAVKPTVAPPLAEPGAGKGLRSEHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEIDMSNIQEMRARHKEAFLKKHNLKLGFMSAFVKASAFALQEQPVVNAVIDDTTKEVVYRDYIDISVAVATPRGLVVPVIRNVEAMNFADIERTITELGEKARKNELAIEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHGIFDRPVAIGGKVEVRPMMYVALTYDHRLIDGREAVTFLRKIKAAVEDPRVLLLDL

Target ORF information:

RefSeq Version	NM_001933.4
Organism	Homo sapiens(human)
Definition	Homo sapiens dihydrolipoamide S-succinyltransferase (DLST), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001933.4

ORF Insert Sequence:

ATGCTGTCCC GATCCCGCTG TGTGTCTCGG GCGTTCAGCC GCTCGCTCTC CGCCTTCCAG 
AAGGGGAACT GCCCTCTAGG GAGACGTTCC CTGCCTGGGG TCTCCTTATG CCAGGGACCA 
GGTTACCCTA ACAGCAGGAA GGTTGTCATT AACAACAGTG TCTTCAGTGT TCGCTTTTTC 
AGAACTACAG CTGTATGCAA GGATGACTTG GTTACAGTCA AAACCCCAGC GTTTGCAGAA 
TCTGTCACAG AGGGAGATGT CAGGTGGGAG AAAGCTGTTG GAGACACAGT TGCAGAAGAT 
GAAGTGGTTT GTGAGATTGA AACTGACAAG ACATCTGTGC AGGTTCCATC ACCAGCAAAT 
GGCGTGATTG AAGCTCTTTT GGTACCTGAT GGGGGAAAAG TCGAAGGAGG CACTCCACTT 
TTCACACTCA GGAAAACTGG TGCTGCTCCT GCTAAGGCCA AGCCGGCTGA AGCTCCTGCT 
GCTGCAGCCC CAAAAGCAGA ACCTACAGCA GCGGCAGTTC CTCCCCCTGC AGCACCCATA 
CCCACTCAGA TGCCACCGGT GCCCTCGCCC TCACAGCCTC CTTCTGGCAA ACCTGTGTCT 
GCAGTAAAAC CCACTGTTGC CCCACCACTA GCTGAGCCAG GAGCTGGCAA AGGTCTGCGT 
TCAGAACATC GGGAGAAAAT GAACAGGATG CGGCAGCGCA TTGCTCAGCG TCTGAAGGAG 
GCCCAGAATA CATGTGCAAT GCTGACAACT TTTAATGAGA TTGACATGAG TAACATCCAG 
GAGATGAGGG CTCGGCACAA AGAGGCTTTT TTGAAGAAAC ATAACCTCAA ACTAGGCTTC 
ATGTCGGCAT TTGTGAAGGC CTCAGCCTTT GCCTTGCAGG AACAGCCTGT TGTAAATGCA 
GTGATTGACG ACACAACCAA AGAGGTGGTG TATAGGGATT ATATTGACAT CAGTGTTGCA 
GTGGCCACCC CACGGGGTCT GGTGGTTCCA GTCATCAGGA ATGTGGAAGC TATGAATTTT 
GCAGATATTG AACGGACCAT CACTGAACTG GGAGAGAAGG CCCGAAAGAA TGAACTTGCC 
ATTGAAGATA TGGATGGCGG TACCTTCACC ATTAGCAATG GAGGCGTTTT TGGCTCGCTC 
TTTGGAACAC CCATTATCAA CCCCCCTCAG TCTGCCATCC TGGGGATGCA TGGCATCTTT 
GACAGGCCAG TGGCTATAGG AGGCAAGGTA GAGGTGCGGC CCATGATGTA CGTGGCACTG 
ACCTATGATC ACCGGCTGAT TGATGGCAGA GAGGCTGTGA CTTTCCTCCG CAAAATCAAG 
GCAGCGGTAG AGGATCCCAG AGTCCTCCTC CTGGATCTTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.
Cell systems5(6)564-577.e12(2017 12)
Malty RH,Aoki H,Kumar A,Phanse S,Amin S,Zhang Q,Minic Z,Goebels F,Musso G,Wu Z,Abou-Tok H,Meyer M,Deineko V,Kassir S,Sidhu V,Jessulat M,Scott NE,Xiong X,Vlasblom J,Prasad B,Foster LJ,Alberio T,Garavaglia B,Yu H,Bader GD,Nakamura K,Parkinson J,Babu M

KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase.
Nature552(7684)273-277(2017 12)
Wang Y,Guo YR,Liu K,Yin Z,Liu R,Xia Y,Tan L,Yang P,Lee JH,Li XJ,Hawke D,Zheng Y,Qian X,Lyu J,He J,Xing D,Tao YJ,Lu Z

The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis.
Leukemia30(6)1365-74(2016 06)
Anderson NM,Li D,Peng HL,Laroche FJ,Mansour MR,Gjini E,Aioub M,Helman DJ,Roderick JE,Cheng T,Harrold I,Samaha Y,Meng L,Amsterdam A,Neuberg DS,Denton TT,Sanda T,Kelliher MA,Singh A,Look AT,Feng H

The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology27(6)2392-406(2013 Jun)
Kiss G,Konrad C,Doczi J,Starkov AA,Kawamata H,Manfredi G,Zhang SF,Gibson GE,Beal MF,Adam-Vizi V,Chinopoulos C

Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study.
Carcinogenesis34(2)307-13(2013 Feb)
Lee Y,Yoon KA,Joo J,Lee D,Bae K,Han JY,Lee JS

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DLST cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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