SPACA4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SPACA4
Entrez Gene ID	171169
Full Name	sperm acrosome associated 4
Synonyms	SAMP14
General protein information	Preferred Names sperm acrosome associated 4 Names sperm acrosome membrane-associated protein 4 sperm acrosomal membrane protein 14 sperm acrosomal membrane-associated protein 14 testicular tissue protein Li 167
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.33
Disorder MIM:	609932

mRNA and Protein(s)

mRNA	Protein	Name
NM_133498.3	NP_598005.1	sperm acrosome membrane-associated protein 4 precursor
NM_133498.2	NP_598005.1	sperm acrosome membrane-associated protein 4 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SPACA4	NP_001070491.1
Rattus norvegicus (Norway rat)	Spaca4	NP_001103093.1
Homo sapiens (human)	SPACA4	NP_598005.1
Pan troglodytes (chimpanzee)	SPACA4	XP_001171475.1
Macaca mulatta (Rhesus monkey)	SPACA4	XP_001114051.1
Mus musculus (house mouse)	Spaca4	NP_081331.2
Canis lupus familiaris (dog)	SPACA4	XP_852068.1

Gene Ontology
Bibliography

Related articles in PubMed

The Ly6/uPAR protein Bouncer is necessary and sufficient for species-specific fertilization.
Herberg S, Gert KR, Schleiffer A, Pauli A
Science (New York, N.Y.)361(6406)1029-1033(2018 09)

Organization, evolution and functions of the human and mouse Ly6/uPAR family genes.
Loughner CL, Bruford EA, McAndrews MS, Delp EE, Swamynathan S, Swamynathan SK
Human genomics1010(2016 Apr)

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A
Genome research13(10)2265-70(2003 Oct)

SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6/urokinase-type plasminogen activator receptor superfamily with a role in sperm-egg interaction.
Shetty J, Wolkowicz MJ, Digilio LC, Klotz KL, Jayes FL, Diekman AB, Westbrook VA, Farris EM, Hao Z, Coonrod SA, Flickinger CJ, Herr JC
The Journal of biological chemistry278(33)30506-15(2003 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SPACA4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SPACA4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30123	NM_133498.3 Latest version!	Homo sapiens sperm acrosome associated 4 (SPACA4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu30123	NM_133498.2	Homo sapiens sperm acrosome associated 4 (SPACA4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SPACA4 ( NM_133498.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_598005.1 Homo sapiens sperm acrosome associated 4 (SPACA4), mRNA.

Price & Availability↑

CloneID	OHu30123
Clone ID Related Accession (Same CDS sequence)	NM_133498.3 , NM_133498.2
Accession Version	NM_133498.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506700800000
Organism	Homo sapiens(human)
Product	sperm acrosome membrane-associated protein 4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF353721.2. On Aug 9, 2003 this sequence version replaced NM_133498.1. ##Evidence-Data-START## Transcript is intronless :: AF353721.2, HM005480.1 [ECO:0000345] ##Evidence-Data-END##

ATGGTCCTGT GCTGGCTGCT GCTTCTGGTG ATGGCTCTGC CCCCAGGCAC GACGGGCGTC 
AAGGACTGCG TCTTCTGTGA GCTCACCGAC TCCATGCAGT GTCCTGGTAC CTACATGCAC 
TGTGGCGATG ACGAGGACTG CTTCACAGGC CACGGGGTCG CCCCGGGCAC TGGTCCGGTC 
ATCAACAAAG GCTGCCTGCG AGCCACCAGC TGCGGCCTTG AGGAACCCGT CAGCTACAGG 
GGCGTCACCT ACAGCCTCAC CACCAACTGC TGCACCGGCC GCCTGTGTAA CAGAGCCCCG 
AGCAGCCAGA CAGTGGGGGC CACCACCAGC CTGGCACTGG GGCTGGGTAT GCTGCTTCCT 
CCACGTTTGC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598005.1
CDS	237..611
Translation	MVLCWLLLLVMALPPGTTGVKDCVFCELTDSMQCPGTYMHCGDDEDCFTGHGVAPGTGPVINKGCLRATSCGLEEPVSYRGVTYSLTTNCCTGRLCNRAPSSQTVGATTSLALGLGMLLPPRLL

Target ORF information:

RefSeq Version	NM_133498.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sperm acrosome associated 4 (SPACA4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133498.2

ORF Insert Sequence:

ATGGTCCTGT GCTGGCTGCT GCTTCTGGTG ATGGCTCTGC CCCCAGGCAC GACGGGCGTC 
AAGGACTGCG TCTTCTGTGA GCTCACCGAC TCCATGCAGT GTCCTGGTAC CTACATGCAC 
TGTGGCGATG ACGAGGACTG CTTCACAGGC CACGGGGTCG CCCCGGGCAC TGGTCCGGTC 
ATCAACAAAG GCTGCCTGCG AGCCACCAGC TGCGGCCTTG AGGAACCCGT CAGCTACAGG 
GGCGTCACCT ACAGCCTCAC CACCAACTGC TGCACCGGCC GCCTGTGTAA CAGAGCCCCG 
AGCAGCCAGA CAGTGGGGGC CACCACCAGC CTGGCACTGG GGCTGGGTAT GCTGCTTCCT 
CCACGTTTGC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPACA4 ( NM_133498.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_598005.1 Homo sapiens sperm acrosome associated 4 (SPACA4), mRNA.

Price & Availability↑

CloneID	OHu30123
Clone ID Related Accession (Same CDS sequence)	NM_133498.3 , NM_133498.2
Accession Version	NM_133498.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1556640000000
Organism	Homo sapiens(human)
Product	sperm acrosome membrane-associated protein 4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC022154.4 and AF353721.2. On Nov 22, 2018 this sequence version replaced NM_133498.2. ##Evidence-Data-START## Transcript is intronless :: HM005480.1, AF353721.2 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000321762.3/ ENSP00000312774.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTCCTGT GCTGGCTGCT GCTTCTGGTG ATGGCTCTGC CCCCAGGCAC GACGGGCGTC 
AAGGACTGCG TCTTCTGTGA GCTCACCGAC TCCATGCAGT GTCCTGGTAC CTACATGCAC 
TGTGGCGATG ACGAGGACTG CTTCACAGGC CACGGGGTCG CCCCGGGCAC TGGTCCGGTC 
ATCAACAAAG GCTGCCTGCG AGCCACCAGC TGCGGCCTTG AGGAACCCGT CAGCTACAGG 
GGCGTCACCT ACAGCCTCAC CACCAACTGC TGCACCGGCC GCCTGTGTAA CAGAGCCCCG 
AGCAGCCAGA CAGTGGGGGC CACCACCAGC CTGGCACTGG GGCTGGGTAT GCTGCTTCCT 
CCACGTTTGC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598005.1
CDS	238..612
Translation	MVLCWLLLLVMALPPGTTGVKDCVFCELTDSMQCPGTYMHCGDDEDCFTGHGVAPGTGPVINKGCLRATSCGLEEPVSYRGVTYSLTTNCCTGRLCNRAPSSQTVGATTSLALGLGMLLPPRLL

Target ORF information:

RefSeq Version	NM_133498.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sperm acrosome associated 4 (SPACA4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133498.3

ORF Insert Sequence:

ATGGTCCTGT GCTGGCTGCT GCTTCTGGTG ATGGCTCTGC CCCCAGGCAC GACGGGCGTC 
AAGGACTGCG TCTTCTGTGA GCTCACCGAC TCCATGCAGT GTCCTGGTAC CTACATGCAC 
TGTGGCGATG ACGAGGACTG CTTCACAGGC CACGGGGTCG CCCCGGGCAC TGGTCCGGTC 
ATCAACAAAG GCTGCCTGCG AGCCACCAGC TGCGGCCTTG AGGAACCCGT CAGCTACAGG 
GGCGTCACCT ACAGCCTCAC CACCAACTGC TGCACCGGCC GCCTGTGTAA CAGAGCCCCG 
AGCAGCCAGA CAGTGGGGGC CACCACCAGC CTGGCACTGG GGCTGGGTAT GCTGCTTCCT 
CCACGTTTGC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Ly6/uPAR protein Bouncer is necessary and sufficient for species-specific fertilization.
Science (New York, N.Y.)361(6406)1029-1033(2018 09)
Herberg S,Gert KR,Schleiffer A,Pauli A

Organization, evolution and functions of the human and mouse Ly6/uPAR family genes.
Human genomics1010(2016 Apr)
Loughner CL,Bruford EA,McAndrews MS,Delp EE,Swamynathan S,Swamynathan SK

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Genome research13(10)2265-70(2003 Oct)
Clark HF,Gurney AL,Abaya E,Baker K,Baldwin D,Brush J,Chen J,Chow B,Chui C,Crowley C,Currell B,Deuel B,Dowd P,Eaton D,Foster J,Grimaldi C,Gu Q,Hass PE,Heldens S,Huang A,Kim HS,Klimowski L,Jin Y,Johnson S,Lee J,Lewis L,Liao D,Mark M,Robbie E,Sanchez C,Schoenfeld J,Seshagiri S,Simmons L,Singh J,Smith V,Stinson J,Vagts A,Vandlen R,Watanabe C,Wieand D,Woods K,Xie MH,Yansura D,Yi S,Yu G,Yuan J,Zhang M,Zhang Z,Goddard A,Wood WI,Godowski P,Gray A

SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6/urokinase-type plasminogen activator receptor superfamily with a role in sperm-egg interaction.
The Journal of biological chemistry278(33)30506-15(2003 Aug)
Shetty J,Wolkowicz MJ,Digilio LC,Klotz KL,Jayes FL,Diekman AB,Westbrook VA,Farris EM,Hao Z,Coonrod SA,Flickinger CJ,Herr JC

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SPACA4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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