GADD45A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GADD45A
Entrez Gene ID	1647
Full Name	growth arrest and DNA damage inducible alpha
Synonyms	DDIT1,GADD45
General protein information	Preferred Names growth arrest and DNA damage inducible alpha Names growth arrest and DNA damage-inducible protein GADD45 alpha DDIT-1 DNA damage-inducible transcript 1 protein DNA damage-inducible transcript-1 growth arrest and DNA-damage-inducible 45 alpha
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p31.3
Summary	This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010].
Disorder MIM:	126335

mRNA and Protein(s)

mRNA	Protein	Name
NM_001199742.2	NP_001186671.1	growth arrest and DNA damage-inducible protein GADD45 alpha isoform 3
NM_001199741.2	NP_001186670.1	growth arrest and DNA damage-inducible protein GADD45 alpha isoform 2
NM_001924.4	NP_001915.1	growth arrest and DNA damage-inducible protein GADD45 alpha isoform 1
NM_001924.3	NP_001915.1	growth arrest and DNA damage-inducible protein GADD45 alpha isoform 1
NM_001199742.1	NP_001186671.1	growth arrest and DNA damage-inducible protein GADD45 alpha isoform 3
NM_001199741.1	NP_001186670.1	growth arrest and DNA damage-inducible protein GADD45 alpha isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	GADD45A	NP_001915.1
Pan troglodytes (chimpanzee)	GADD45A	XP_513476.2
Macaca mulatta (Rhesus monkey)	GADD45A	XP_001095413.1
Bos taurus (cattle)	GADD45A	NP_001029419.1
Mus musculus (house mouse)	Gadd45a	NP_031862.1
Danio rerio (zebrafish)	gadd45ab	NP_001002216.1
Danio rerio (zebrafish)	gadd45aa	NP_956870.1
Gallus gallus (chicken)	GADD45A	NP_001038143.1
Rattus norvegicus (Norway rat)	Gadd45a	NP_077041.2
Xenopus tropicalis (tropical clawed frog)	gadd45a	NP_001016151.1
Canis lupus familiaris (dog)	GADD45A	XP_003639149.1

Gene Ontology
Bibliography

Related articles in PubMed

GADD45A binds R-loops and recruits TET1 to CpG island promoters.
Arab K, Karaulanov E, Musheev M, Trnka P, Schäfer A, Grummt I, Niehrs C
Nature genetics51(2)217-223(2019 02)

Transcriptional repression of IKKβ by p53 in arsenite-induced GADD45α accumulation and apoptosis.
Hu Y, Jin R, Gao M, Xu H, Zou S, Li X, Xing C, Wang Q, Wang H, Feng J, Hu M, Song L
Oncogene38(5)731-746(2019 01)

Long non-coding RNA DLX6-AS1 is upregulated in preeclampsia and modulates migration and invasion of trophoblasts through the miR-376c/GADD45A axis.
Tan Y, Xiao D, Xu Y, Wang C
Experimental cell research370(2)718-724(2018 09)

Gadd45a knockdown alleviates oxidative stress through suppressing the p38 MAPK signaling pathway in the pathogenesis of preeclampsia.
Li FH, Han N, Wang Y, Xu Q
Placenta6520-28(2018 05)

Differential expression of vitamin D associated genes in the aorta of coronary artery disease patients with and without rheumatoid arthritis.
Oma I, Olstad OK, Andersen JK, Lyberg T, Molberg Ø, Fostad I, Wang Fagerland M, Almdahl SM, Rynning SE, Yndestad A, Aukrust P, Whist JE, Hollan I
PloS one13(8)e0202346(2018)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GADD45A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GADD45A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19971	NM_001199742.2 Latest version!	Homo sapiens growth arrest and DNA damage inducible alpha (GADD45A), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu20157	NM_001199741.2 Latest version!	Homo sapiens growth arrest and DNA damage inducible alpha (GADD45A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu19958	NM_001924.4 Latest version!	Homo sapiens growth arrest and DNA damage inducible alpha (GADD45A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu19958	NM_001924.3	Homo sapiens growth arrest and DNA damage inducible alpha (GADD45A), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu19971	NM_001199742.1	Homo sapiens growth arrest and DNA damage inducible alpha (GADD45A), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu20157	NM_001199741.1	Homo sapiens growth arrest and DNA damage inducible alpha (GADD45A), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GADD45A ( NM_001199742.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001186671.1 Homo sapiens growth arrest and DNA damage inducible alpha (GADD45A), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu19971
Clone ID Related Accession (Same CDS sequence)	NM_001199742.2 , NM_001199742.1
Accession Version	NM_001199742.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 183bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577980800000
Organism	Homo sapiens(human)
Product	growth arrest and DNA damage-inducible protein GADD45 alpha isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK314991.1, EF581092.1 and BU629410.1. On May 31, 2019 this sequence version replaced NM_001199742.1. Transcript Variant: This variant (3) lacks a coding exon, as compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EF581092.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149004, SAMEA2162823 [ECO:0000348] ##Evidence-Data-END##

ATGACTTTGG AGGAATTCTC GGCTGGAGAG CAGAAGACCG AAAGGATGGA TAAGGTGGGG 
GATGCCCTGG AGGAAGTGCT CAGCAAAGCC CTGAGTCAGC GCACGATCAC TGTCGGGGTG 
TACGAAGCGG CCAAGCTGCT CAACGTAATC CACATTCATC TCAATGGAAG GATCCTGCCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186671.1
CDS	295..477
Translation	MTLEEFSAGEQKTERMDKVGDALEEVLSKALSQRTITVGVYEAAKLLNVIHIHLNGRILP

Target ORF information:

RefSeq Version	NM_001199742.2
Organism	Homo sapiens(human)
Definition	Homo sapiens growth arrest and DNA damage inducible alpha (GADD45A), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199742.2

ORF Insert Sequence:

ATGACTTTGG AGGAATTCTC GGCTGGAGAG CAGAAGACCG AAAGGATGGA TAAGGTGGGG 
GATGCCCTGG AGGAAGTGCT CAGCAAAGCC CTGAGTCAGC GCACGATCAC TGTCGGGGTG 
TACGAAGCGG CCAAGCTGCT CAACGTAATC CACATTCATC TCAATGGAAG GATCCTGCCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GADD45A ( NM_001199742.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001186671.1 Homo sapiens growth arrest and DNA damage inducible alpha (GADD45A), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu19971
Clone ID Related Accession (Same CDS sequence)	NM_001199742.2 , NM_001199742.1
Accession Version	NM_001199742.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 183bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1551542400000
Organism	Homo sapiens(human)
Product	growth arrest and DNA damage-inducible protein GADD45 alpha isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK314991.1, EF581092.1 and BU629410.1. Transcript Variant: This variant (3) lacks a coding exon, as compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EF581092.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149004, SAMEA2162823 [ECO:0000348] ##Evidence-Data-END##

ATGACTTTGG AGGAATTCTC GGCTGGAGAG CAGAAGACCG AAAGGATGGA TAAGGTGGGG 
GATGCCCTGG AGGAAGTGCT CAGCAAAGCC CTGAGTCAGC GCACGATCAC TGTCGGGGTG 
TACGAAGCGG CCAAGCTGCT CAACGTAATC CACATTCATC TCAATGGAAG GATCCTGCCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186671.1
CDS	319..501
Translation	MTLEEFSAGEQKTERMDKVGDALEEVLSKALSQRTITVGVYEAAKLLNVIHIHLNGRILP

Target ORF information:

RefSeq Version	NM_001199742.1
Organism	Homo sapiens(human)
Definition	Homo sapiens growth arrest and DNA damage inducible alpha (GADD45A), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199742.1

ORF Insert Sequence:

ATGACTTTGG AGGAATTCTC GGCTGGAGAG CAGAAGACCG AAAGGATGGA TAAGGTGGGG 
GATGCCCTGG AGGAAGTGCT CAGCAAAGCC CTGAGTCAGC GCACGATCAC TGTCGGGGTG 
TACGAAGCGG CCAAGCTGCT CAACGTAATC CACATTCATC TCAATGGAAG GATCCTGCCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GADD45A ( NM_001199741.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001186670.1 Homo sapiens growth arrest and DNA damage inducible alpha (GADD45A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20157
Clone ID Related Accession (Same CDS sequence)	NM_001199741.2 , NM_001199741.1
Accession Version	NM_001199741.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 396bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1570377600000
Organism	Homo sapiens(human)
Product	growth arrest and DNA damage-inducible protein GADD45 alpha isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK314991.1, DQ008445.1 and BU629410.1. On May 31, 2019 this sequence version replaced NM_001199741.1. Transcript Variant: This variant (2) lacks an in-frame exon in the CDS and encodes a shorter isoform (2), as compared to variant 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG545949.1, SRR1163657.312306.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END##

ATGACTTTGG AGGAATTCTC GGCTGGAGAG CAGAAGACCG AAAGCGACCC CGATAACGTG 
GTGTTGTGCC TGCTGGCGGC GGACGAGGAC GACGACAGAG ATGTGGCTCT GCAGATCCAC 
TTCACCCTGA TCCAGGCGTT TTGCTGCGAG AACGACATCA ACATCCTGCG CGTCAGCAAC 
CCGGGCCGGC TGGCGGAGCT CCTGCTCTTG GAGACCGACG CTGGCCCCGC GGCGAGCGAG 
GGCGCCGAGC AGCCCCCGGA CCTGCACTGC GTGCTGGTGA CGAATCCACA TTCATCTCAA 
TGGAAGGATC CTGCCTTAAG TCAACTTATT TGTTTTTGCC GGGAAAGTCG CTACATGGAT 
CAATGGGTTC CAGTGATTAA TCTCCCTGAA CGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186670.1
CDS	295..690
Translation	MTLEEFSAGEQKTESDPDNVVLCLLAADEDDDRDVALQIHFTLIQAFCCENDINILRVSNPGRLAELLLLETDAGPAASEGAEQPPDLHCVLVTNPHSSQWKDPALSQLICFCRESRYMDQWVPVINLPER

Target ORF information:

RefSeq Version	NM_001199741.2
Organism	Homo sapiens(human)
Definition	Homo sapiens growth arrest and DNA damage inducible alpha (GADD45A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199741.2

ORF Insert Sequence:

ATGACTTTGG AGGAATTCTC GGCTGGAGAG CAGAAGACCG AAAGCGACCC CGATAACGTG 
GTGTTGTGCC TGCTGGCGGC GGACGAGGAC GACGACAGAG ATGTGGCTCT GCAGATCCAC 
TTCACCCTGA TCCAGGCGTT TTGCTGCGAG AACGACATCA ACATCCTGCG CGTCAGCAAC 
CCGGGCCGGC TGGCGGAGCT CCTGCTCTTG GAGACCGACG CTGGCCCCGC GGCGAGCGAG 
GGCGCCGAGC AGCCCCCGGA CCTGCACTGC GTGCTGGTGA CGAATCCACA TTCATCTCAA 
TGGAAGGATC CTGCCTTAAG TCAACTTATT TGTTTTTGCC GGGAAAGTCG CTACATGGAT 
CAATGGGTTC CAGTGATTAA TCTCCCTGAA CGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GADD45A ( NM_001199741.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001186670.1 Homo sapiens growth arrest and DNA damage inducible alpha (GADD45A), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20157
Clone ID Related Accession (Same CDS sequence)	NM_001199741.2 , NM_001199741.1
Accession Version	NM_001199741.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 396bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1551542400000
Organism	Homo sapiens(human)
Product	growth arrest and DNA damage-inducible protein GADD45 alpha isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK314991.1, DQ008445.1 and BU629410.1. Transcript Variant: This variant (2) lacks an in-frame exon in the CDS and encodes a shorter isoform (2), as compared to variant 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.312306.1, SRR1163657.301496.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END##

ATGACTTTGG AGGAATTCTC GGCTGGAGAG CAGAAGACCG AAAGCGACCC CGATAACGTG 
GTGTTGTGCC TGCTGGCGGC GGACGAGGAC GACGACAGAG ATGTGGCTCT GCAGATCCAC 
TTCACCCTGA TCCAGGCGTT TTGCTGCGAG AACGACATCA ACATCCTGCG CGTCAGCAAC 
CCGGGCCGGC TGGCGGAGCT CCTGCTCTTG GAGACCGACG CTGGCCCCGC GGCGAGCGAG 
GGCGCCGAGC AGCCCCCGGA CCTGCACTGC GTGCTGGTGA CGAATCCACA TTCATCTCAA 
TGGAAGGATC CTGCCTTAAG TCAACTTATT TGTTTTTGCC GGGAAAGTCG CTACATGGAT 
CAATGGGTTC CAGTGATTAA TCTCCCTGAA CGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186670.1
CDS	319..714
Translation	MTLEEFSAGEQKTESDPDNVVLCLLAADEDDDRDVALQIHFTLIQAFCCENDINILRVSNPGRLAELLLLETDAGPAASEGAEQPPDLHCVLVTNPHSSQWKDPALSQLICFCRESRYMDQWVPVINLPER

Target ORF information:

RefSeq Version	NM_001199741.1
Organism	Homo sapiens(human)
Definition	Homo sapiens growth arrest and DNA damage inducible alpha (GADD45A), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199741.1

ORF Insert Sequence:

ATGACTTTGG AGGAATTCTC GGCTGGAGAG CAGAAGACCG AAAGCGACCC CGATAACGTG 
GTGTTGTGCC TGCTGGCGGC GGACGAGGAC GACGACAGAG ATGTGGCTCT GCAGATCCAC 
TTCACCCTGA TCCAGGCGTT TTGCTGCGAG AACGACATCA ACATCCTGCG CGTCAGCAAC 
CCGGGCCGGC TGGCGGAGCT CCTGCTCTTG GAGACCGACG CTGGCCCCGC GGCGAGCGAG 
GGCGCCGAGC AGCCCCCGGA CCTGCACTGC GTGCTGGTGA CGAATCCACA TTCATCTCAA 
TGGAAGGATC CTGCCTTAAG TCAACTTATT TGTTTTTGCC GGGAAAGTCG CTACATGGAT 
CAATGGGTTC CAGTGATTAA TCTCCCTGAA CGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GADD45A ( NM_001924.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001915.1 Homo sapiens growth arrest and DNA damage inducible alpha (GADD45A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19958
Clone ID Related Accession (Same CDS sequence)	NM_001924.4 , NM_001924.3
Accession Version	NM_001924.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 498bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	growth arrest and DNA damage-inducible protein GADD45 alpha isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK314991.1 and M60974.1. On Nov 22, 2018 this sequence version replaced NM_001924.3. Transcript Variant: This variant (1) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.705608.1, SRR1163658.469431.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370986.9/ ENSP00000360025.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACTTTGG AGGAATTCTC GGCTGGAGAG CAGAAGACCG AAAGGATGGA TAAGGTGGGG 
GATGCCCTGG AGGAAGTGCT CAGCAAAGCC CTGAGTCAGC GCACGATCAC TGTCGGGGTG 
TACGAAGCGG CCAAGCTGCT CAACGTCGAC CCCGATAACG TGGTGTTGTG CCTGCTGGCG 
GCGGACGAGG ACGACGACAG AGATGTGGCT CTGCAGATCC ACTTCACCCT GATCCAGGCG 
TTTTGCTGCG AGAACGACAT CAACATCCTG CGCGTCAGCA ACCCGGGCCG GCTGGCGGAG 
CTCCTGCTCT TGGAGACCGA CGCTGGCCCC GCGGCGAGCG AGGGCGCCGA GCAGCCCCCG 
GACCTGCACT GCGTGCTGGT GACGAATCCA CATTCATCTC AATGGAAGGA TCCTGCCTTA 
AGTCAACTTA TTTGTTTTTG CCGGGAAAGT CGCTACATGG ATCAATGGGT TCCAGTGATT 
AATCTCCCTG AACGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001915.1
CDS	295..792
Translation	MTLEEFSAGEQKTERMDKVGDALEEVLSKALSQRTITVGVYEAAKLLNVDPDNVVLCLLAADEDDDRDVALQIHFTLIQAFCCENDINILRVSNPGRLAELLLLETDAGPAASEGAEQPPDLHCVLVTNPHSSQWKDPALSQLICFCRESRYMDQWVPVINLPER

Target ORF information:

RefSeq Version	NM_001924.4
Organism	Homo sapiens(human)
Definition	Homo sapiens growth arrest and DNA damage inducible alpha (GADD45A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001924.4

ORF Insert Sequence:

ATGACTTTGG AGGAATTCTC GGCTGGAGAG CAGAAGACCG AAAGGATGGA TAAGGTGGGG 
GATGCCCTGG AGGAAGTGCT CAGCAAAGCC CTGAGTCAGC GCACGATCAC TGTCGGGGTG 
TACGAAGCGG CCAAGCTGCT CAACGTCGAC CCCGATAACG TGGTGTTGTG CCTGCTGGCG 
GCGGACGAGG ACGACGACAG AGATGTGGCT CTGCAGATCC ACTTCACCCT GATCCAGGCG 
TTTTGCTGCG AGAACGACAT CAACATCCTG CGCGTCAGCA ACCCGGGCCG GCTGGCGGAG 
CTCCTGCTCT TGGAGACCGA CGCTGGCCCC GCGGCGAGCG AGGGCGCCGA GCAGCCCCCG 
GACCTGCACT GCGTGCTGGT GACGAATCCA CATTCATCTC AATGGAAGGA TCCTGCCTTA 
AGTCAACTTA TTTGTTTTTG CCGGGAAAGT CGCTACATGG ATCAATGGGT TCCAGTGATT 
AATCTCCCTG AACGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GADD45A ( NM_001924.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001915.1 Homo sapiens growth arrest and DNA damage inducible alpha (GADD45A), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19958
Clone ID Related Accession (Same CDS sequence)	NM_001924.4 , NM_001924.3
Accession Version	NM_001924.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 498bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1512403200000
Organism	Homo sapiens(human)
Product	growth arrest and DNA damage-inducible protein GADD45 alpha isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK314991.1, M60974.1 and BU629410.1. On Dec 15, 2010 this sequence version replaced NM_001924.2. Transcript Variant: This variant (1) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK314991.1, SRR1163658.469431.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGACTTTGG AGGAATTCTC GGCTGGAGAG CAGAAGACCG AAAGGATGGA TAAGGTGGGG 
GATGCCCTGG AGGAAGTGCT CAGCAAAGCC CTGAGTCAGC GCACGATCAC TGTCGGGGTG 
TACGAAGCGG CCAAGCTGCT CAACGTCGAC CCCGATAACG TGGTGTTGTG CCTGCTGGCG 
GCGGACGAGG ACGACGACAG AGATGTGGCT CTGCAGATCC ACTTCACCCT GATCCAGGCG 
TTTTGCTGCG AGAACGACAT CAACATCCTG CGCGTCAGCA ACCCGGGCCG GCTGGCGGAG 
CTCCTGCTCT TGGAGACCGA CGCTGGCCCC GCGGCGAGCG AGGGCGCCGA GCAGCCCCCG 
GACCTGCACT GCGTGCTGGT GACGAATCCA CATTCATCTC AATGGAAGGA TCCTGCCTTA 
AGTCAACTTA TTTGTTTTTG CCGGGAAAGT CGCTACATGG ATCAATGGGT TCCAGTGATT 
AATCTCCCTG AACGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001915.1
CDS	319..816
Translation	MTLEEFSAGEQKTERMDKVGDALEEVLSKALSQRTITVGVYEAAKLLNVDPDNVVLCLLAADEDDDRDVALQIHFTLIQAFCCENDINILRVSNPGRLAELLLLETDAGPAASEGAEQPPDLHCVLVTNPHSSQWKDPALSQLICFCRESRYMDQWVPVINLPER

Target ORF information:

RefSeq Version	NM_001924.3
Organism	Homo sapiens(human)
Definition	Homo sapiens growth arrest and DNA damage inducible alpha (GADD45A), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001924.3

ORF Insert Sequence:

ATGACTTTGG AGGAATTCTC GGCTGGAGAG CAGAAGACCG AAAGGATGGA TAAGGTGGGG 
GATGCCCTGG AGGAAGTGCT CAGCAAAGCC CTGAGTCAGC GCACGATCAC TGTCGGGGTG 
TACGAAGCGG CCAAGCTGCT CAACGTCGAC CCCGATAACG TGGTGTTGTG CCTGCTGGCG 
GCGGACGAGG ACGACGACAG AGATGTGGCT CTGCAGATCC ACTTCACCCT GATCCAGGCG 
TTTTGCTGCG AGAACGACAT CAACATCCTG CGCGTCAGCA ACCCGGGCCG GCTGGCGGAG 
CTCCTGCTCT TGGAGACCGA CGCTGGCCCC GCGGCGAGCG AGGGCGCCGA GCAGCCCCCG 
GACCTGCACT GCGTGCTGGT GACGAATCCA CATTCATCTC AATGGAAGGA TCCTGCCTTA 
AGTCAACTTA TTTGTTTTTG CCGGGAAAGT CGCTACATGG ATCAATGGGT TCCAGTGATT 
AATCTCCCTG AACGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

GADD45A binds R-loops and recruits TET1 to CpG island promoters.
Nature genetics51(2)217-223(2019 02)
Arab K,Karaulanov E,Musheev M,Trnka P,Schäfer A,Grummt I,Niehrs C

Transcriptional repression of IKKβ by p53 in arsenite-induced GADD45α accumulation and apoptosis.
Oncogene38(5)731-746(2019 01)
Hu Y,Jin R,Gao M,Xu H,Zou S,Li X,Xing C,Wang Q,Wang H,Feng J,Hu M,Song L

Long non-coding RNA DLX6-AS1 is upregulated in preeclampsia and modulates migration and invasion of trophoblasts through the miR-376c/GADD45A axis.
Experimental cell research370(2)718-724(2018 09)
Tan Y,Xiao D,Xu Y,Wang C

Gadd45a knockdown alleviates oxidative stress through suppressing the p38 MAPK signaling pathway in the pathogenesis of preeclampsia.
Placenta6520-28(2018 05)
Li FH,Han N,Wang Y,Xu Q

Differential expression of vitamin D associated genes in the aorta of coronary artery disease patients with and without rheumatoid arthritis.
PloS one13(8)e0202346(2018)
Oma I,Olstad OK,Andersen JK,Lyberg T,Molberg Ø,Fostad I,Wang Fagerland M,Almdahl SM,Rynning SE,Yndestad A,Aukrust P,Whist JE,Hollan I

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GADD45A cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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