CMTM4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CMTM4
Entrez Gene ID	146223
Full Name	CKLF like MARVEL transmembrane domain containing 4
Synonyms	CKLFSF4
General protein information	Preferred Names CKLF like MARVEL transmembrane domain containing 4 Names CKLF-like MARVEL transmembrane domain-containing protein 4 chemokine-like factor super family 4 chemokine-like factor superfamily member 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q21-q22.1
Summary	This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Disorder MIM:	607887

mRNA and Protein(s)

mRNA	Protein	Name
NM_181521.2	NP_852662.1	CKLF-like MARVEL transmembrane domain-containing protein 4 isoform 2
XM_011522882.1	XP_011521184.1	CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X2
XM_017022954.1	XP_016878443.1	CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X1
NM_178818.2	NP_848933.1	CKLF-like MARVEL transmembrane domain-containing protein 4 isoform 1
NM_178818.3	NP_848933.1	CKLF-like MARVEL transmembrane domain-containing protein 4 isoform 1
NM_181521.3	NP_852662.1	CKLF-like MARVEL transmembrane domain-containing protein 4 isoform 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CMTM4	NP_001077218.1
Gallus gallus (chicken)	CMTM4	XP_414155.3
Homo sapiens (human)	CMTM4	NP_848933.1
Danio rerio (zebrafish)	cmtm4	NP_001002492.1
Xenopus tropicalis (tropical clawed frog)	LOC100498042	XP_002933695.1
Pan troglodytes (chimpanzee)	CMTM4	XP_523385.2
Rattus norvegicus (Norway rat)	Cmtm4	NP_001165622.1
Mus musculus (house mouse)	Cmtm4	NP_705810.2

Gene Ontology
Bibliography

Related articles in PubMed

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity.
Burr ML, Sparbier CE, Chan YC, Williamson JC, Woods K, Beavis PA, Lam EYN, Henderson MA, Bell CC, Stolzenburg S, Gilan O, Bloor S, Noori T, Morgens DW, Bassik MC, Neeson PJ, Behren A, Darcy PK, Dawson SJ, Voskoboinik I, Trapani JA, Cebon J, Lehner PJ, Dawson MA
Nature549(7670)101-105(2017 09)

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators.
Mezzadra R, Sun C, Jae LT, Gomez-Eerland R, de Vries E, Wu W, Logtenberg MEW, Slagter M, Rozeman EA, Hofland I, Broeks A, Horlings HM, Wessels LFA, Blank CU, Xiao Y, Heck AJR, Borst J, Brummelkamp TR, Schumacher TNM
Nature549(7670)106-110(2017 09)

CMTM4 is frequently downregulated and functions as a tumour suppressor in clear cell renal cell carcinoma.
Li T, Cheng Y, Wang P, Wang W, Hu F, Mo X, Lv H, Xu T, Han W
Journal of experimental & clinical cancer research : CR34122(2015 Oct)

Identification and characterization of CMTM4, a novel gene with inhibitory effects on HeLa cell growth through Inducing G2/M phase accumulation.
Plate M, Li T, Wang Y, Mo X, Zhang Y, Ma D, Han W
Molecules and cells29(4)355-61(2010 Apr)

Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation.
Han W, Ding P, Xu M, Wang L, Rui M, Shi S, Liu Y, Zheng Y, Chen Y, Yang T, Ma D
Genomics81(6)609-17(2003 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CMTM4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CMTM4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07578	NM_181521.3 Latest version!	Homo sapiens CKLF like MARVEL transmembrane domain containing 4 (CMTM4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu76212	XM_011522882.1 Latest version!	Homo sapiens CKLF like MARVEL transmembrane domain containing 4 (CMTM4), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu85866	XM_017022954.1 Latest version!	Homo sapiens CKLF like MARVEL transmembrane domain containing 4 (CMTM4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu07533	NM_178818.3 Latest version!	Homo sapiens CKLF like MARVEL transmembrane domain containing 4 (CMTM4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
View Old Accession Versions >>
OHu07533	NM_178818.2	Homo sapiens CKLF like MARVEL transmembrane domain containing 4 (CMTM4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
OHu07578	NM_181521.2	Homo sapiens CKLF like MARVEL transmembrane domain containing 4 (CMTM4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CMTM4 ( NM_181521.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_852662.1 Homo sapiens CKLF like MARVEL transmembrane domain containing 4 (CMTM4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07578
Clone ID Related Accession (Same CDS sequence)	NM_181521.2 , NM_181521.3
Accession Version	NM_181521.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550246400000
Organism	Homo sapiens(human)
Product	CKLF-like MARVEL transmembrane domain-containing protein 4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF479814.1, AC018557.9 and AW207043.1. On Nov 18, 2005 this sequence version replaced NM_181521.1. Transcript Variant: This variant (2) includes an additional segment in the 3' coding region that leads to an upstream stop codon, compared to variant 1. The encoded protein (isoform 2) has a shorter C-terminus compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AF479814.1, AL530351.3 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGGAGCG GCGAGGAGCT GGACGGCTTC GAGGGCGAGG CCTCGAGCAC CTCCATGATC 
TCGGGCGCCA GCAGCCCGTA CCAGCCCACC ACCGAGCCGG TGAGCCAGCG CCGCGGGCTG 
GCCGGCCTGC GCTGCGACCC CGACTACCTG CGCGGCGCGC TCGGCCGCCT CAAGGTCGCC 
CAAGTGATCT TGGCCCTGAT TGCATTCATC TGCATAGAGA CCATCATGGC ATGCTCCCCG 
TGTGAAGGCC TCTACTTTTT TGAGTTTGTG AGCTGCAGTG CGTTTGTGGT GACTGGCGTC 
TTGCTGATTA TGTTCAGTCT CAACCTGCAC ATGAGGATCC CCCAGATCAA CTGGAATCTG 
ACAGATTTGG TCAACACTGG ACTCAGCGCT TTCCTTTTCT TTATTGCTTC AATCGTACTG 
GCTGCTTTAA ACCATAGAGC CGGAGCAGAA ATTGCTGCCG TGATATTTGG CTTCTTGGCG 
ACTGCGGCAT ATGCAGTGAA CACATTCCTG GCAGTGCAGA AATGGAGAGT CAGCGTCCGC 
CAGCAGAGCA CCAATGACTA CATCCGAGCC CGCACGGAGT CCAGGGATGT GGACAGTCGC 
CCTGAGATCC AGCGCCTGGA CACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_852662.1
CDS	183..809
Translation	MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNLTDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDT

Target ORF information:

RefSeq Version	NM_181521.2
Organism	Homo sapiens(human)
Definition	Homo sapiens CKLF like MARVEL transmembrane domain containing 4 (CMTM4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181521.2

ORF Insert Sequence:

ATGCGGAGCG GCGAGGAGCT GGACGGCTTC GAGGGCGAGG CCTCGAGCAC CTCCATGATC 
TCGGGCGCCA GCAGCCCGTA CCAGCCCACC ACCGAGCCGG TGAGCCAGCG CCGCGGGCTG 
GCCGGCCTGC GCTGCGACCC CGACTACCTG CGCGGCGCGC TCGGCCGCCT CAAGGTCGCC 
CAAGTGATCT TGGCCCTGAT TGCATTCATC TGCATAGAGA CCATCATGGC ATGCTCCCCG 
TGTGAAGGCC TCTACTTTTT TGAGTTTGTG AGCTGCAGTG CGTTTGTGGT GACTGGCGTC 
TTGCTGATTA TGTTCAGTCT CAACCTGCAC ATGAGGATCC CCCAGATCAA CTGGAATCTG 
ACAGATTTGG TCAACACTGG ACTCAGCGCT TTCCTTTTCT TTATTGCTTC AATCGTACTG 
GCTGCTTTAA ACCATAGAGC CGGAGCAGAA ATTGCTGCCG TGATATTTGG CTTCTTGGCG 
ACTGCGGCAT ATGCAGTGAA CACATTCCTG GCAGTGCAGA AATGGAGAGT CAGCGTCCGC 
CAGCAGAGCA CCAATGACTA CATCCGAGCC CGCACGGAGT CCAGGGATGT GGACAGTCGC 
CCTGAGATCC AGCGCCTGGA CACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CMTM4 ( NM_181521.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_852662.1 Homo sapiens CKLF like MARVEL transmembrane domain containing 4 (CMTM4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07578
Clone ID Related Accession (Same CDS sequence)	NM_181521.2 , NM_181521.3
Accession Version	NM_181521.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569686400000
Organism	Homo sapiens(human)
Product	CKLF-like MARVEL transmembrane domain-containing protein 4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC018557.9, AF479814.1 and AW207043.1. On Jun 3, 2019 this sequence version replaced NM_181521.2. Transcript Variant: This variant (2) includes an additional segment in the 3' coding region that leads to an upstream stop codon, compared to variant 1. The encoded protein (isoform 2) has a shorter C-terminus compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: DRR138516.66279.1, DRR138528.1108492.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCGGAGCG GCGAGGAGCT GGACGGCTTC GAGGGCGAGG CCTCGAGCAC CTCCATGATC 
TCGGGCGCCA GCAGCCCGTA CCAGCCCACC ACCGAGCCGG TGAGCCAGCG CCGCGGGCTG 
GCCGGCCTGC GCTGCGACCC CGACTACCTG CGCGGCGCGC TCGGCCGCCT CAAGGTCGCC 
CAAGTGATCT TGGCCCTGAT TGCATTCATC TGCATAGAGA CCATCATGGC ATGCTCCCCG 
TGTGAAGGCC TCTACTTTTT TGAGTTTGTG AGCTGCAGTG CGTTTGTGGT GACTGGCGTC 
TTGCTGATTA TGTTCAGTCT CAACCTGCAC ATGAGGATCC CCCAGATCAA CTGGAATCTG 
ACAGATTTGG TCAACACTGG ACTCAGCGCT TTCCTTTTCT TTATTGCTTC AATCGTACTG 
GCTGCTTTAA ACCATAGAGC CGGAGCAGAA ATTGCTGCCG TGATATTTGG CTTCTTGGCG 
ACTGCGGCAT ATGCAGTGAA CACATTCCTG GCAGTGCAGA AATGGAGAGT CAGCGTCCGC 
CAGCAGAGCA CCAATGACTA CATCCGAGCC CGCACGGAGT CCAGGGATGT GGACAGTCGC 
CCTGAGATCC AGCGCCTGGA CACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_852662.1
CDS	219..845
Translation	MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNLTDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDT

Target ORF information:

RefSeq Version	NM_181521.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CKLF like MARVEL transmembrane domain containing 4 (CMTM4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181521.3

ORF Insert Sequence:

ATGCGGAGCG GCGAGGAGCT GGACGGCTTC GAGGGCGAGG CCTCGAGCAC CTCCATGATC 
TCGGGCGCCA GCAGCCCGTA CCAGCCCACC ACCGAGCCGG TGAGCCAGCG CCGCGGGCTG 
GCCGGCCTGC GCTGCGACCC CGACTACCTG CGCGGCGCGC TCGGCCGCCT CAAGGTCGCC 
CAAGTGATCT TGGCCCTGAT TGCATTCATC TGCATAGAGA CCATCATGGC ATGCTCCCCG 
TGTGAAGGCC TCTACTTTTT TGAGTTTGTG AGCTGCAGTG CGTTTGTGGT GACTGGCGTC 
TTGCTGATTA TGTTCAGTCT CAACCTGCAC ATGAGGATCC CCCAGATCAA CTGGAATCTG 
ACAGATTTGG TCAACACTGG ACTCAGCGCT TTCCTTTTCT TTATTGCTTC AATCGTACTG 
GCTGCTTTAA ACCATAGAGC CGGAGCAGAA ATTGCTGCCG TGATATTTGG CTTCTTGGCG 
ACTGCGGCAT ATGCAGTGAA CACATTCCTG GCAGTGCAGA AATGGAGAGT CAGCGTCCGC 
CAGCAGAGCA CCAATGACTA CATCCGAGCC CGCACGGAGT CCAGGGATGT GGACAGTCGC 
CCTGAGATCC AGCGCCTGGA CACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CMTM4 ( XM_011522882.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011521184.1 Homo sapiens CKLF like MARVEL transmembrane domain containing 4 (CMTM4), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu76212
Clone ID Related Accession (Same CDS sequence)	XM_011522882.1
Accession Version	XM_011522882.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGGAGCG GCGAGGAGCT GGACGGCTTC GAGGGCGAGG CCTCGAGCAC CTCCATGATC 
TCGGGCGCCA GCAGCCCGTA CCAGCCCACC ACCGAGCCGA TCTTGGCCCT GATTGCATTC 
ATCTGCATAG AGACCATCAT GGCATGCTCC CCGTGTGAAG GCCTCTACTT TTTTGAGTTT 
GTGAGCTGCA GTGCGTTTGT GGTGACTGGC GTCTTGCTGA TTATGTTCAG TCTCAACCTG 
CACATGAGGA TCCCCCAGAT CAACTGGAAT CTGACAGATT TGGTCAACAC TGGACTCAGC 
GCTTTCCTTT TCTTTATTGC TTCAATCGTA CTGGCTGCTT TAAACCATAG AGCCGGAGCA 
GAAATTGCTG CCGTGATATT TGGCTTCTTG GCGACTGCGG CATATGCAGT GAACACATTC 
CTGGCAGTGC AGAAATGGAG AGTCAGCGTC CGCCAGCAGA GCACCAATGA CTACATCCGA 
GCCCGCACGG AGTCCAGGGA TGTGGACAGT CGCCCTGAGA TCCAGCGCCT GGACACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011521184.1
CDS	178..717
Translation	MRSGEELDGFEGEASSTSMISGASSPYQPTTEPILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNLTDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDT

Target ORF information:

RefSeq Version	XM_011522882.1
Organism	Homo sapiens(human)
Definition	Homo sapiens CKLF like MARVEL transmembrane domain containing 4 (CMTM4), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011522882.1

ORF Insert Sequence:

ATGCGGAGCG GCGAGGAGCT GGACGGCTTC GAGGGCGAGG CCTCGAGCAC CTCCATGATC 
TCGGGCGCCA GCAGCCCGTA CCAGCCCACC ACCGAGCCGA TCTTGGCCCT GATTGCATTC 
ATCTGCATAG AGACCATCAT GGCATGCTCC CCGTGTGAAG GCCTCTACTT TTTTGAGTTT 
GTGAGCTGCA GTGCGTTTGT GGTGACTGGC GTCTTGCTGA TTATGTTCAG TCTCAACCTG 
CACATGAGGA TCCCCCAGAT CAACTGGAAT CTGACAGATT TGGTCAACAC TGGACTCAGC 
GCTTTCCTTT TCTTTATTGC TTCAATCGTA CTGGCTGCTT TAAACCATAG AGCCGGAGCA 
GAAATTGCTG CCGTGATATT TGGCTTCTTG GCGACTGCGG CATATGCAGT GAACACATTC 
CTGGCAGTGC AGAAATGGAG AGTCAGCGTC CGCCAGCAGA GCACCAATGA CTACATCCGA 
GCCCGCACGG AGTCCAGGGA TGTGGACAGT CGCCCTGAGA TCCAGCGCCT GGACACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CMTM4 ( XM_017022954.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016878443.1 Homo sapiens CKLF like MARVEL transmembrane domain containing 4 (CMTM4), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu85866
Clone ID Related Accession (Same CDS sequence)	XM_017022954.1
Accession Version	XM_017022954.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 666bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	CKLF-like MARVEL transmembrane domain-containing protein 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGGAGCG GCGAGGAGCT GGACGGCTTC GAGGGCGAGG CCTCGAGCAC CTCCATGATC 
TCGGGCGCCA GCAGCCCGTA CCAGCCCACC ACCGAGCCGG TGAGCCAGCG CCGCGGGCTG 
GCCGGCCTGC GCTGCGACCC CGACTACCTG CGCGGCGCGC TCGGCCGCCT CAAGGTCGCC 
CAAGTGATCT TGGCCCTGAT TGCATTCATC TGCATAGAGA CCATCATGGC ATGCTCCCCG 
TGTGAAGGCC TCTACTTTTT TGAGTTTGTG AGCTGCAGTG CGTTTGTGGT GACTGGCGTC 
TTGCTGATTA TGTTCAGTCT CAACCTGCAC ATGAGGATCC CCCAGATCAA CTGGAATCTG 
ACAGATTTGG TCAACACTGG ACTCAGCGCT TTCCTTTTCT TTATTGCTTC AATCGTACTG 
GCTGCTTTAA ACCATAGAGC CGGAGCAGAA ATTGCTGCCG TGATATTTGG CTTCTTGGCG 
ACTGCGGCAT ATGCAGTGAA CACATTCCTG GCAGTGCAGA AATGGAGAGT CAGCGTCCGC 
CAGCAGAGCA CCAATGACTA CATCCGAGCC CGCACGGAGT CCAGGGATGT GGACAGTCGC 
CCTGAGATCC AGCGCCTGGA CACCCTGAAC TGGAAACCAA ATGGCCATCA ACAGGTGAAG 
GGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016878443.1
CDS	87..752
Translation	MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNLTDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDTLNWKPNGHQQVKG

Target ORF information:

RefSeq Version	XM_017022954.1
Organism	Homo sapiens(human)
Definition	Homo sapiens CKLF like MARVEL transmembrane domain containing 4 (CMTM4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017022954.1

ORF Insert Sequence:

ATGCGGAGCG GCGAGGAGCT GGACGGCTTC GAGGGCGAGG CCTCGAGCAC CTCCATGATC 
TCGGGCGCCA GCAGCCCGTA CCAGCCCACC ACCGAGCCGG TGAGCCAGCG CCGCGGGCTG 
GCCGGCCTGC GCTGCGACCC CGACTACCTG CGCGGCGCGC TCGGCCGCCT CAAGGTCGCC 
CAAGTGATCT TGGCCCTGAT TGCATTCATC TGCATAGAGA CCATCATGGC ATGCTCCCCG 
TGTGAAGGCC TCTACTTTTT TGAGTTTGTG AGCTGCAGTG CGTTTGTGGT GACTGGCGTC 
TTGCTGATTA TGTTCAGTCT CAACCTGCAC ATGAGGATCC CCCAGATCAA CTGGAATCTG 
ACAGATTTGG TCAACACTGG ACTCAGCGCT TTCCTTTTCT TTATTGCTTC AATCGTACTG 
GCTGCTTTAA ACCATAGAGC CGGAGCAGAA ATTGCTGCCG TGATATTTGG CTTCTTGGCG 
ACTGCGGCAT ATGCAGTGAA CACATTCCTG GCAGTGCAGA AATGGAGAGT CAGCGTCCGC 
CAGCAGAGCA CCAATGACTA CATCCGAGCC CGCACGGAGT CCAGGGATGT GGACAGTCGC 
CCTGAGATCC AGCGCCTGGA CACCCTGAAC TGGAAACCAA ATGGCCATCA ACAGGTGAAG 
GGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CMTM4 ( NM_178818.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_848933.1 Homo sapiens CKLF like MARVEL transmembrane domain containing 4 (CMTM4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu07533
Clone ID Related Accession (Same CDS sequence)	NM_178818.2 , NM_178818.3
Accession Version	NM_178818.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 705bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550160000000
Organism	Homo sapiens(human)
Product	CKLF-like MARVEL transmembrane domain-containing protein 4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF521889.1. On or before Mar 4, 2006 this sequence version replaced XM_940220.1, NM_178818.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AF521889.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGGAGCG GCGAGGAGCT GGACGGCTTC GAGGGCGAGG CCTCGAGCAC CTCCATGATC 
TCGGGCGCCA GCAGCCCGTA CCAGCCCACC ACCGAGCCGG TGAGCCAGCG CCGCGGGCTG 
GCCGGCCTGC GCTGCGACCC CGACTACCTG CGCGGCGCGC TCGGCCGCCT CAAGGTCGCC 
CAAGTGATCT TGGCCCTGAT TGCATTCATC TGCATAGAGA CCATCATGGC ATGCTCCCCG 
TGTGAAGGCC TCTACTTTTT TGAGTTTGTG AGCTGCAGTG CGTTTGTGGT GACTGGCGTC 
TTGCTGATTA TGTTCAGTCT CAACCTGCAC ATGAGGATCC CCCAGATCAA CTGGAATCTG 
ACAGATTTGG TCAACACTGG ACTCAGCGCT TTCCTTTTCT TTATTGCTTC AATCGTACTG 
GCTGCTTTAA ACCATAGAGC CGGAGCAGAA ATTGCTGCCG TGATATTTGG CTTCTTGGCG 
ACTGCGGCAT ATGCAGTGAA CACATTCCTG GCAGTGCAGA AATGGAGAGT CAGCGTCCGC 
CAGCAGAGCA CCAATGACTA CATCCGAGCC CGCACGGAGT CCAGGGATGT GGACAGTCGC 
CCTGAGATCC AGCGCCTGGA CACTTTTTCC TACTCCACAA ACGTAACAGT AAGGAAAAAA 
TCACCCACAA ACCTGCTGAG TTTGAATCAC TGGCAACTTG CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_848933.1
CDS	183..887
Translation	MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNLTDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA

Target ORF information:

RefSeq Version	NM_178818.2
Organism	Homo sapiens(human)
Definition	Homo sapiens CKLF like MARVEL transmembrane domain containing 4 (CMTM4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178818.2

ORF Insert Sequence:

ATGCGGAGCG GCGAGGAGCT GGACGGCTTC GAGGGCGAGG CCTCGAGCAC CTCCATGATC 
TCGGGCGCCA GCAGCCCGTA CCAGCCCACC ACCGAGCCGG TGAGCCAGCG CCGCGGGCTG 
GCCGGCCTGC GCTGCGACCC CGACTACCTG CGCGGCGCGC TCGGCCGCCT CAAGGTCGCC 
CAAGTGATCT TGGCCCTGAT TGCATTCATC TGCATAGAGA CCATCATGGC ATGCTCCCCG 
TGTGAAGGCC TCTACTTTTT TGAGTTTGTG AGCTGCAGTG CGTTTGTGGT GACTGGCGTC 
TTGCTGATTA TGTTCAGTCT CAACCTGCAC ATGAGGATCC CCCAGATCAA CTGGAATCTG 
ACAGATTTGG TCAACACTGG ACTCAGCGCT TTCCTTTTCT TTATTGCTTC AATCGTACTG 
GCTGCTTTAA ACCATAGAGC CGGAGCAGAA ATTGCTGCCG TGATATTTGG CTTCTTGGCG 
ACTGCGGCAT ATGCAGTGAA CACATTCCTG GCAGTGCAGA AATGGAGAGT CAGCGTCCGC 
CAGCAGAGCA CCAATGACTA CATCCGAGCC CGCACGGAGT CCAGGGATGT GGACAGTCGC 
CCTGAGATCC AGCGCCTGGA CACTTTTTCC TACTCCACAA ACGTAACAGT AAGGAAAAAA 
TCACCCACAA ACCTGCTGAG TTTGAATCAC TGGCAACTTG CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CMTM4 ( NM_178818.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_848933.1 Homo sapiens CKLF like MARVEL transmembrane domain containing 4 (CMTM4), transcript variant 1, mRNA.

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CloneID	OHu07533
Clone ID Related Accession (Same CDS sequence)	NM_178818.2 , NM_178818.3
Accession Version	NM_178818.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 705bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569600000000
Organism	Homo sapiens(human)
Product	CKLF-like MARVEL transmembrane domain-containing protein 4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC018557.9 and AF521889.1. On Jun 2, 2019 this sequence version replaced NM_178818.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AF521889.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGGAGCG GCGAGGAGCT GGACGGCTTC GAGGGCGAGG CCTCGAGCAC CTCCATGATC 
TCGGGCGCCA GCAGCCCGTA CCAGCCCACC ACCGAGCCGG TGAGCCAGCG CCGCGGGCTG 
GCCGGCCTGC GCTGCGACCC CGACTACCTG CGCGGCGCGC TCGGCCGCCT CAAGGTCGCC 
CAAGTGATCT TGGCCCTGAT TGCATTCATC TGCATAGAGA CCATCATGGC ATGCTCCCCG 
TGTGAAGGCC TCTACTTTTT TGAGTTTGTG AGCTGCAGTG CGTTTGTGGT GACTGGCGTC 
TTGCTGATTA TGTTCAGTCT CAACCTGCAC ATGAGGATCC CCCAGATCAA CTGGAATCTG 
ACAGATTTGG TCAACACTGG ACTCAGCGCT TTCCTTTTCT TTATTGCTTC AATCGTACTG 
GCTGCTTTAA ACCATAGAGC CGGAGCAGAA ATTGCTGCCG TGATATTTGG CTTCTTGGCG 
ACTGCGGCAT ATGCAGTGAA CACATTCCTG GCAGTGCAGA AATGGAGAGT CAGCGTCCGC 
CAGCAGAGCA CCAATGACTA CATCCGAGCC CGCACGGAGT CCAGGGATGT GGACAGTCGC 
CCTGAGATCC AGCGCCTGGA CACTTTTTCC TACTCCACAA ACGTAACAGT AAGGAAAAAA 
TCACCCACAA ACCTGCTGAG TTTGAATCAC TGGCAACTTG CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_848933.1
CDS	219..923
Translation	MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNLTDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA

Target ORF information:

RefSeq Version	NM_178818.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CKLF like MARVEL transmembrane domain containing 4 (CMTM4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178818.3

ORF Insert Sequence:

ATGCGGAGCG GCGAGGAGCT GGACGGCTTC GAGGGCGAGG CCTCGAGCAC CTCCATGATC 
TCGGGCGCCA GCAGCCCGTA CCAGCCCACC ACCGAGCCGG TGAGCCAGCG CCGCGGGCTG 
GCCGGCCTGC GCTGCGACCC CGACTACCTG CGCGGCGCGC TCGGCCGCCT CAAGGTCGCC 
CAAGTGATCT TGGCCCTGAT TGCATTCATC TGCATAGAGA CCATCATGGC ATGCTCCCCG 
TGTGAAGGCC TCTACTTTTT TGAGTTTGTG AGCTGCAGTG CGTTTGTGGT GACTGGCGTC 
TTGCTGATTA TGTTCAGTCT CAACCTGCAC ATGAGGATCC CCCAGATCAA CTGGAATCTG 
ACAGATTTGG TCAACACTGG ACTCAGCGCT TTCCTTTTCT TTATTGCTTC AATCGTACTG 
GCTGCTTTAA ACCATAGAGC CGGAGCAGAA ATTGCTGCCG TGATATTTGG CTTCTTGGCG 
ACTGCGGCAT ATGCAGTGAA CACATTCCTG GCAGTGCAGA AATGGAGAGT CAGCGTCCGC 
CAGCAGAGCA CCAATGACTA CATCCGAGCC CGCACGGAGT CCAGGGATGT GGACAGTCGC 
CCTGAGATCC AGCGCCTGGA CACTTTTTCC TACTCCACAA ACGTAACAGT AAGGAAAAAA 
TCACCCACAA ACCTGCTGAG TTTGAATCAC TGGCAACTTG CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity.
Nature549(7670)101-105(2017 09)
Burr ML,Sparbier CE,Chan YC,Williamson JC,Woods K,Beavis PA,Lam EYN,Henderson MA,Bell CC,Stolzenburg S,Gilan O,Bloor S,Noori T,Morgens DW,Bassik MC,Neeson PJ,Behren A,Darcy PK,Dawson SJ,Voskoboinik I,Trapani JA,Cebon J,Lehner PJ,Dawson MA

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators.
Nature549(7670)106-110(2017 09)
Mezzadra R,Sun C,Jae LT,Gomez-Eerland R,de Vries E,Wu W,Logtenberg MEW,Slagter M,Rozeman EA,Hofland I,Broeks A,Horlings HM,Wessels LFA,Blank CU,Xiao Y,Heck AJR,Borst J,Brummelkamp TR,Schumacher TNM

CMTM4 is frequently downregulated and functions as a tumour suppressor in clear cell renal cell carcinoma.
Journal of experimental & clinical cancer research : CR34122(2015 Oct)
Li T,Cheng Y,Wang P,Wang W,Hu F,Mo X,Lv H,Xu T,Han W

Identification and characterization of CMTM4, a novel gene with inhibitory effects on HeLa cell growth through Inducing G2/M phase accumulation.
Molecules and cells29(4)355-61(2010 Apr)
Plate M,Li T,Wang Y,Mo X,Zhang Y,Ma D,Han W

Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation.
Genomics81(6)609-17(2003 Jun)
Han W,Ding P,Xu M,Wang L,Rui M,Shi S,Liu Y,Zheng Y,Chen Y,Yang T,Ma D

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CMTM4 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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