| Gene Symbol | KERA |
| Entrez Gene ID | 11081 |
| Full Name | keratocan |
| Synonyms | CNA2,KTN,SLRR2B |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2).[provided by RefSeq, May 2010]. |
| Disorder MIM: | |
| Disorder Html: | Cornea plana 2, autosomal recessive, 217300 (3) |
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KERA cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following KERA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KERA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu18735 Clone ID Related Accession (Same CDS sequence) NM_007035.3 Accession Version NM_007035.3 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1059bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577116800000 Organism Homo sapiens(human) Product keratocan precursor Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC078873.22, CV571245.1, BC032667.2 and BM722433.1. This sequence is a reference standard in the RefSeqGene project. On Apr 22, 2005 this sequence version replaced NM_007035.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF205403.1, AK314990.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146982, SAMEA2155371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021ATGGCAGGCA CAATCTGTTT CATCATGTGG GTGTTATTCA TAACAGACAC TGTGTGGTCT
AGAAGTGTGA GGCAGGTCTA TGAAGTACAT GATTCAGATG ATTGGACTAT TCATGACTTC
GAGTGTCCCA TGGAATGTTT CTGCCCACCC AGTTTTCCTA CTGCTTTATA TTGTGAAAAT
AGAGGTCTCA AAGAAATTCC TGCTATTCCT TCAAGAATTT GGTATCTTTA TCTTCAAAAC
AACCTGATAG AAACCATTCC TGAAAAGCCA TTTGAGAATG CCACCCAGCT AAGATGGATA
AATCTAAACA AGAACAAAAT AACCAACTAC GGAATTGAAA AAGGAGCCCT AAGCCAGCTG
AAGAAGTTGC TCTTCTTATT TCTGGAAGAT AATGAGCTAG AGGAGGTACC TTCTCCATTG
CCAAGAAGTT TAGAACAATT ACAATTAGCT AGAAATAAGG TGTCCAGAAT TCCTCAAGGG
ACCTTTAGCA ATCTGGAGAA CCTGACCCTT CTTGACCTAC AGAACAACAA ATTAGTGGAC
AATGCCTTTC AAAGAGACAC TTTTAAAGGA CTCAAGAATC TCATGCAGCT AAACATGGCC
AAGAATGCCC TGAGGAATAT GCCTCCAAGA TTACCAGCCA ATACAATGCA GTTGTTTTTA
GACAACAATT CCATTGAAGG AATACCAGAA AATTATTTTA ATGTGATTCC TAAAGTGGCC
TTTTTGAGAC TAAATCACAA CAAACTGTCA GATGAGGGTC TCCCATCAAG AGGATTTGAT
GTATCATCAA TTCTAGATCT TCAACTGTCG CACAATCAAC TCACAAAGGT TCCCCGAATC
AGTGCTCATC TGCAGCACCT TCACCTTGAT CATAACAAAA TTAAAAGTGT GAATGTCTCT
GTAATATGTC CCAGCCCATC CATGCTGCCT GCAGAACGAG ATTCCTTCAG TTATGGACCT
CATCTTCGCT ACCTCCGTCT GGATGGAAAT GAAATCAAAC CACCAATTCC AATGGCTTTA
ATGACCTGCT TCAGACTTCT GCAGGCTGTC ATTATTTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_008966.1 CDS 620..1678 Translation 
Target ORF information:
RefSeq Version NM_007035.3 Organism Homo sapiens(human) Definition Homo sapiens keratocan (KERA), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_007035.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021ATGGCAGGCA CAATCTGTTT CATCATGTGG GTGTTATTCA TAACAGACAC TGTGTGGTCT
AGAAGTGTGA GGCAGGTCTA TGAAGTACAT GATTCAGATG ATTGGACTAT TCATGACTTC
GAGTGTCCCA TGGAATGTTT CTGCCCACCC AGTTTTCCTA CTGCTTTATA TTGTGAAAAT
AGAGGTCTCA AAGAAATTCC TGCTATTCCT TCAAGAATTT GGTATCTTTA TCTTCAAAAC
AACCTGATAG AAACCATTCC TGAAAAGCCA TTTGAGAATG CCACCCAGCT AAGATGGATA
AATCTAAACA AGAACAAAAT AACCAACTAC GGAATTGAAA AAGGAGCCCT AAGCCAGCTG
AAGAAGTTGC TCTTCTTATT TCTGGAAGAT AATGAGCTAG AGGAGGTACC TTCTCCATTG
CCAAGAAGTT TAGAACAATT ACAATTAGCT AGAAATAAGG TGTCCAGAAT TCCTCAAGGG
ACCTTTAGCA ATCTGGAGAA CCTGACCCTT CTTGACCTAC AGAACAACAA ATTAGTGGAC
AATGCCTTTC AAAGAGACAC TTTTAAAGGA CTCAAGAATC TCATGCAGCT AAACATGGCC
AAGAATGCCC TGAGGAATAT GCCTCCAAGA TTACCAGCCA ATACAATGCA GTTGTTTTTA
GACAACAATT CCATTGAAGG AATACCAGAA AATTATTTTA ATGTGATTCC TAAAGTGGCC
TTTTTGAGAC TAAATCACAA CAAACTGTCA GATGAGGGTC TCCCATCAAG AGGATTTGAT
GTATCATCAA TTCTAGATCT TCAACTGTCG CACAATCAAC TCACAAAGGT TCCCCGAATC
AGTGCTCATC TGCAGCACCT TCACCTTGAT CATAACAAAA TTAAAAGTGT GAATGTCTCT
GTAATATGTC CCAGCCCATC CATGCTGCCT GCAGAACGAG ATTCCTTCAG TTATGGACCT
CATCTTCGCT ACCTCCGTCT GGATGGAAAT GAAATCAAAC CACCAATTCC AATGGCTTTA
ATGACCTGCT TCAGACTTCT GCAGGCTGTC ATTATTTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Analysis of KERA in four families with cornea plana identifies two novel mutations.
Acta ophthalmologica96(1)e87-e91(2018 Feb)
Dudakova L,Vercruyssen JHJ,Balikova I,Postolache L,Leroy BP,Skalicka P,Liskova P
Corneal ectasia in a boy with homozygous KERA mutation.
Ophthalmic genetics39(1)141-143(2018 Jan-Feb)
Khan AO
A Novel KERA Mutation in a Case of Autosomal Recessive Cornea Plana With Primary Angle-Closure Glaucoma.
Journal of glaucoma25(2)e106-9(2016 Feb)
Kumari D,Tiwari A,Choudhury M,Kumar A,Rao A,Dixit M
Case report: a novel KERA mutation associated with cornea plana and its predicted effect on protein function.
BMC medical genetics1640(2015 Jun)
Roos L,Bertelsen B,Harris P,Bygum A,Jensen H,Grønskov K,Tümer Z
Mutation in KERA identified by linkage analysis and targeted resequencing in a pedigree with premature atherosclerosis.
PloS one9(5)e98289(2014)
Maiwald S,Sivapalaratnam S,Motazacker MM,van Capelleveen JC,Bot I,de Jager SC,van Eck M,Jolley J,Kuiper J,Stephens J,Albers CA,Vosmeer CR,Kruize H,Geerke DP,van der Wal AC,van der Loos CM,Kastelein JJ,Trip MD,Ouwehand WH,Dallinga-Thie GM,Hovingh GK
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