CORIN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CORIN
Entrez Gene ID	10699
Full Name	corin, serine peptidase
Synonyms	ATC2,CRN,Lrp4,PEE5,TMPRSS10
General protein information	Preferred Names corin, serine peptidase Names atrial natriuretic peptide-converting enzyme heart-specific serine proteinase ATC2 pro-ANP-convertase pro-ANP-converting enzyme transmembrane protease serine 10
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4p12
Summary	This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013].
Disorder MIM:	605236
Disorder Html:	Preeclampsia/eclampsia 5, 614595 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001278586.2	NP_001265515.1	atrial natriuretic peptide-converting enzyme isoform 3
NM_006587.4	NP_006578.2	atrial natriuretic peptide-converting enzyme isoform 1
NM_006587.3	NP_006578.2	atrial natriuretic peptide-converting enzyme isoform 1
NM_001278585.1	NP_001265514.1	atrial natriuretic peptide-converting enzyme isoform 2
NM_001278586.1	NP_001265515.1	atrial natriuretic peptide-converting enzyme isoform 3

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CORIN	XP_005207990.1
Xenopus tropicalis (tropical clawed frog)	corin	XP_002933508.2
Macaca mulatta (Rhesus monkey)	CORIN	XP_001102245.1
Homo sapiens (human)	CORIN	NP_006578.2
Mus musculus (house mouse)	Corin	NP_058565.2
Rattus norvegicus (Norway rat)	Corin	NP_872279.1
Gallus gallus (chicken)	CORIN	XP_003641257.2
Canis lupus familiaris (dog)	CORIN	XP_005628222.1
Danio rerio (zebrafish)	si:ch1073-76a20.1	XP_005174214.1
Pan troglodytes (chimpanzee)	CORIN	XP_001153181.1

Gene Ontology
Bibliography

Related articles in PubMed

Role of Corin in Blood Pressure Regulation in Normotensive and Hypertensive Pregnancy.
Badrov MB, Park SY, Yoo JK, Hieda M, Okada Y, Jarvis SS, Stickford AS, Best SA, Nelson DB, Fu Q
Hypertension (Dallas, Tex. : 1979)73(2)432-439(2019 02)

Corin is a key regulator of endochondral ossification and bone development via modulation of vascular endothelial growth factor A expression.
Nordberg RC, Wang H, Wu Q, Loboa EG
Journal of tissue engineering and regenerative medicine12(12)2277-2286(2018 12)

Corin is highly expressed in atherosclerosis models.
Jiang J, Zhou Q, Sun M, Zuo F, Jiang J
Biochemical and biophysical research communications504(2)440-446(2018 10)

Association of rs2271037 and rs3749585 polymorphisms in CORIN with susceptibility to hypertension in a Chinese Han population: A case-control study.
Chen YL, Li TJ, Hao Y, Wu BG, Li H, Geng N, Sun ZQ, Zheng LQ, Sun YX
Gene65179-85(2018 Apr)

Aberrant pro-atrial natriuretic peptide/corin/natriuretic peptide receptor signaling is present in maternal vascular endothelium in preeclampsia.
Gu Y, Thompson D, Xu J, Lewis DF, Morgan JA, Cooper DB, McCathran CE, Wang Y
Pregnancy hypertension111-6(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CORIN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CORIN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20561	NM_006587.4 Latest version!	Homo sapiens corin, serine peptidase (CORIN), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$399.50-$559.30 $799.00
OHu14294	NM_001278586.2 Latest version!	Homo sapiens corin, serine peptidase (CORIN), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OHu14763	NM_001278585.1 Latest version!	Homo sapiens corin, serine peptidase (CORIN), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
View Old Accession Versions >>
OHu20561	NM_006587.3	Homo sapiens corin, serine peptidase (CORIN), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$399.50-$559.30 $799.00
OHu14294	NM_001278586.1	Homo sapiens corin, serine peptidase (CORIN), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CORIN ( NM_006587.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006578.2 Homo sapiens corin, serine peptidase (CORIN), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20561
Clone ID Related Accession (Same CDS sequence)	NM_006587.4 , NM_006587.3
Accession Version	NM_006587.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3129bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1574611200000
Organism	Homo sapiens(human)
Product	atrial natriuretic peptide-converting enzyme isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK304466.1, AF133845.1, AC092597.1 and AI378383.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_006587.3. Transcript Variant: This variant (1) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF133845.1, BC110451.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000273857.9/ ENSP00000273857.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAACAGT CTCCTGCCCT CGCTCCGGAA GAGCGCTGCC GCAGAGCCGG GTCCCCAAAG 
CCGGTCTTGA GAGCTGATGA CAATAACATG GGCAATGGCT GCTCTCAGAA GCTGGCGACT 
GCTAACCTCC TCCGGTTCCT ATTGCTGGTC CTGATTCCAT GTATCTGTGC TCTCGTTCTC 
TTGCTGGTGA TCCTGCTTTC CTATGTTGGA ACATTACAAA AGGTCTATTT TAAATCAAAT 
GGGAGTGAAC CTTTGGTCAC TGATGGTGAA ATCCAAGGGT CCGATGTTAT TCTTACAAAT 
ACAATTTATA ACCAGAGCAC TGTGGTGTCT ACTGCACATC CCGACCAACA CGTTCCAGCC 
TGGACTACGG ATGCTTCTCT CCCAGGGGAC CAAAGTCACA GGAATACAAG TGCCTGTATG 
AACATCACCC ACAGCCAGTG TCAGATGCTG CCCTACCACG CCACGCTGAC ACCTCTCCTC 
TCAGTTGTCA GAAACATGGA AATGGAAAAG TTCCTCAAGT TTTTCACATA TCTCCATCGC 
CTCAGTTGCT ATCAACATAT CATGCTGTTT GGCTGTACCC TCGCCTTCCC TGAGTGCATC 
ATTGATGGCG ATGACAGTCA TGGACTCCTG CCCTGTAGGT CCTTCTGTGA GGCTGCAAAA 
GAAGGCTGTG AATCAGTCCT GGGGATGGTG AATTACTCCT GGCCGGATTT CCTCAGATGC 
TCCCAGTTTA GAAACCAAAC TGAAAGCAGC AATGTCAGCA GAATTTGCTT CTCACCTCAG 
CAGGAAAACG GAAAGCAATT GCTCTGTGGA AGGGGTGAGA ACTTTCTGTG TGCCAGTGGA 
ATCTGCATCC CCGGGAAACT GCAATGTAAT GGCTACAACG ACTGTGACGA CTGGAGTGAC 
GAGGCTCATT GCAACTGCAG CGAGAATCTG TTTCACTGTC ACACAGGCAA GTGCCTTAAT 
TACAGCCTTG TGTGTGATGG ATATGATGAC TGTGGGGATT TGAGTGATGA GCAAAACTGT 
GATTGCAATC CCACAACAGA GCATCGCTGC GGGGACGGGC GCTGCATCGC CATGGAGTGG 
GTGTGTGATG GTGACCACGA CTGTGTGGAT AAGTCTGACG AGGTCAACTG CTCCTGTCAC 
AGCCAGGGTC TGGTGGAATG CAGAAATGGA CAATGTATCC CCAGCACGTT TCAATGTGAT 
GGTGACGAGG ACTGCAAGGA TGGGAGTGAT GAGGAGAACT GCAGCGTCAT TCAGACTTCA 
TGTCAAGAAG GAGACCAAAG ATGCCTCTAC AATCCCTGCC TTGATTCATG TGGTGGTAGC 
TCTCTCTGTG ACCCGAACAA CAGTCTGAAT AACTGTAGTC AATGTGAACC AATTACATTG 
GAACTCTGCA TGAATTTGCC CTACAACAGT ACAAGTTATC CAAATTATTT TGGCCACAGG 
ACTCAAAAGG AAGCATCCAT CAGCTGGGAG TCTTCTCTTT TCCCTGCACT TGTTCAAACC 
AACTGTTATA AATACCTCAT GTTCTTTTCT TGCACCATTT TGGTACCAAA ATGTGATGTG 
AATACAGGCG AGCATATCCC TCCTTGCAGG GCATTGTGTG AACACTCTAA AGAACGCTGT 
GAGTCTGTTC TTGGGATTGT GGGCCTACAG TGGCCTGAAG ACACAGATTG CAGTCAATTT 
CCAGAGGAAA ATTCAGACAA TCAAACCTGC CTGATGCCTG ATGAATATGT GGAAGAATGC 
TCACCTAGTC ATTTCAAGTG CCGCTCAGGA CAGTGTGTTC TGGCTTCCAG AAGATGTGAT 
GGCCAGGCCG ACTGTGACGA TGACAGTGAT GAGGAAAACT GTGGTTGTAA AGAGAGAGAT 
CTTTGGGAAT GTCCATCCAA TAAACAATGT TTGAAGCACA CAGTGATCTG CGATGGGTTC 
CCAGACTGCC CTGATTACAT GGACGAGAAA AACTGCTCAT TTTGCCAAGA TGATGAGCTG 
GAATGTGCAA ACCATGCGTG TGTGTCACGT GACCTGTGGT GTGATGGTGA AGCCGACTGC 
TCAGACAGTT CAGATGAATG GGACTGTGTG ACCCTCTCTA TAAATGTGAA CTCCTCTTCC 
TTTCTGATGG TTCACAGAGC TGCCACAGAA CACCATGTGT GTGCAGATGG CTGGCAGGAG 
ATATTGAGTC AGCTGGCCTG CAAGCAGATG GGTTTAGGAG AACCATCTGT GACCAAATTG 
ATACAGGAAC AGGAGAAAGA GCCGCGGTGG CTGACATTAC ACTCCAACTG GGAGAGCCTC 
AATGGGACCA CTTTACATGA ACTTCTAGTA AATGGGCAGT CTTGTGAGAG CAGAAGTAAA 
ATTTCTCTTC TGTGTACTAA ACAAGACTGT GGGCGCCGCC CTGCTGCCCG AATGAACAAA 
AGGATCCTTG GAGGTCGGAC GAGTCGCCCT GGAAGGTGGC CATGGCAGTG TTCTCTGCAG 
AGTGAACCCA GTGGACATAT CTGTGGCTGT GTCCTCATTG CCAAGAAGTG GGTTCTGACA 
GTTGCCCACT GCTTCGAGGG GAGAGAGAAT GCTGCAGTTT GGAAAGTGGT GCTTGGCATC 
AACAATCTAG ACCATCCATC AGTGTTCATG CAGACACGCT TTGTGAAGAC CATCATCCTG 
CATCCCCGCT ACAGTCGAGC AGTGGTGGAC TATGACATCA GCATCGTTGA GCTGAGTGAA 
GACATCAGTG AGACTGGCTA CGTCCGGCCT GTCTGCTTGC CCAACCCGGA GCAGTGGCTA 
GAGCCTGACA CGTACTGCTA TATCACAGGC TGGGGCCACA TGGGCAATAA AATGCCATTT 
AAGCTGCAAG AGGGAGAGGT CCGCATTATT TCTCTGGAAC ATTGTCAGTC CTACTTTGAC 
ATGAAGACCA TCACCACTCG GATGATATGT GCTGGCTATG AGTCTGGCAC AGTTGATTCA 
TGCATGGGTG ACAGCGGTGG GCCTCTTGTT TGTGAGAAGC CTGGAGGACG GTGGACATTA 
TTTGGATTAA CTTCATGGGG CTCCGTCTGC TTTTCCAAAG TCCTGGGGCC TGGCGTTTAT 
AGTAATGTGT CATATTTCGT CGAATGGATT AAAAGACAGA TTTACATCCA GACCTTTCTC 
CTAAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006578.2
CDS	119..3247
Translation	MKQSPALAPEERCRRAGSPKPVLRADDNNMGNGCSQKLATANLLRFLLLVLIPCICALVLLLVILLSYVGTLQKVYFKSNGSEPLVTDGEIQGSDVILTNTIYNQSTVVSTAHPDQHVPAWTTDASLPGDQSHRNTSACMNITHSQCQMLPYHATLTPLLSVVRNMEMEKFLKFFTYLHRLSCYQHIMLFGCTLAFPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVSRICFSPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVCADGWQEILSQLACKQMGLGEPSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQSCESRSKISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGRENAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDISETGYVRPVCLPNPEQWLEPDTYCYITGWGHMGNKMPFKLQEGEVRIISLEHCQSYFDMKTITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVYSNVSYFVEWIKRQIYIQTFLLN

Target ORF information:

RefSeq Version	NM_006587.4
Organism	Homo sapiens(human)
Definition	Homo sapiens corin, serine peptidase (CORIN), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006587.4

ORF Insert Sequence:

ATGAAACAGT CTCCTGCCCT CGCTCCGGAA GAGCGCTGCC GCAGAGCCGG GTCCCCAAAG 
CCGGTCTTGA GAGCTGATGA CAATAACATG GGCAATGGCT GCTCTCAGAA GCTGGCGACT 
GCTAACCTCC TCCGGTTCCT ATTGCTGGTC CTGATTCCAT GTATCTGTGC TCTCGTTCTC 
TTGCTGGTGA TCCTGCTTTC CTATGTTGGA ACATTACAAA AGGTCTATTT TAAATCAAAT 
GGGAGTGAAC CTTTGGTCAC TGATGGTGAA ATCCAAGGGT CCGATGTTAT TCTTACAAAT 
ACAATTTATA ACCAGAGCAC TGTGGTGTCT ACTGCACATC CCGACCAACA CGTTCCAGCC 
TGGACTACGG ATGCTTCTCT CCCAGGGGAC CAAAGTCACA GGAATACAAG TGCCTGTATG 
AACATCACCC ACAGCCAGTG TCAGATGCTG CCCTACCACG CCACGCTGAC ACCTCTCCTC 
TCAGTTGTCA GAAACATGGA AATGGAAAAG TTCCTCAAGT TTTTCACATA TCTCCATCGC 
CTCAGTTGCT ATCAACATAT CATGCTGTTT GGCTGTACCC TCGCCTTCCC TGAGTGCATC 
ATTGATGGCG ATGACAGTCA TGGACTCCTG CCCTGTAGGT CCTTCTGTGA GGCTGCAAAA 
GAAGGCTGTG AATCAGTCCT GGGGATGGTG AATTACTCCT GGCCGGATTT CCTCAGATGC 
TCCCAGTTTA GAAACCAAAC TGAAAGCAGC AATGTCAGCA GAATTTGCTT CTCACCTCAG 
CAGGAAAACG GAAAGCAATT GCTCTGTGGA AGGGGTGAGA ACTTTCTGTG TGCCAGTGGA 
ATCTGCATCC CCGGGAAACT GCAATGTAAT GGCTACAACG ACTGTGACGA CTGGAGTGAC 
GAGGCTCATT GCAACTGCAG CGAGAATCTG TTTCACTGTC ACACAGGCAA GTGCCTTAAT 
TACAGCCTTG TGTGTGATGG ATATGATGAC TGTGGGGATT TGAGTGATGA GCAAAACTGT 
GATTGCAATC CCACAACAGA GCATCGCTGC GGGGACGGGC GCTGCATCGC CATGGAGTGG 
GTGTGTGATG GTGACCACGA CTGTGTGGAT AAGTCTGACG AGGTCAACTG CTCCTGTCAC 
AGCCAGGGTC TGGTGGAATG CAGAAATGGA CAATGTATCC CCAGCACGTT TCAATGTGAT 
GGTGACGAGG ACTGCAAGGA TGGGAGTGAT GAGGAGAACT GCAGCGTCAT TCAGACTTCA 
TGTCAAGAAG GAGACCAAAG ATGCCTCTAC AATCCCTGCC TTGATTCATG TGGTGGTAGC 
TCTCTCTGTG ACCCGAACAA CAGTCTGAAT AACTGTAGTC AATGTGAACC AATTACATTG 
GAACTCTGCA TGAATTTGCC CTACAACAGT ACAAGTTATC CAAATTATTT TGGCCACAGG 
ACTCAAAAGG AAGCATCCAT CAGCTGGGAG TCTTCTCTTT TCCCTGCACT TGTTCAAACC 
AACTGTTATA AATACCTCAT GTTCTTTTCT TGCACCATTT TGGTACCAAA ATGTGATGTG 
AATACAGGCG AGCATATCCC TCCTTGCAGG GCATTGTGTG AACACTCTAA AGAACGCTGT 
GAGTCTGTTC TTGGGATTGT GGGCCTACAG TGGCCTGAAG ACACAGATTG CAGTCAATTT 
CCAGAGGAAA ATTCAGACAA TCAAACCTGC CTGATGCCTG ATGAATATGT GGAAGAATGC 
TCACCTAGTC ATTTCAAGTG CCGCTCAGGA CAGTGTGTTC TGGCTTCCAG AAGATGTGAT 
GGCCAGGCCG ACTGTGACGA TGACAGTGAT GAGGAAAACT GTGGTTGTAA AGAGAGAGAT 
CTTTGGGAAT GTCCATCCAA TAAACAATGT TTGAAGCACA CAGTGATCTG CGATGGGTTC 
CCAGACTGCC CTGATTACAT GGACGAGAAA AACTGCTCAT TTTGCCAAGA TGATGAGCTG 
GAATGTGCAA ACCATGCGTG TGTGTCACGT GACCTGTGGT GTGATGGTGA AGCCGACTGC 
TCAGACAGTT CAGATGAATG GGACTGTGTG ACCCTCTCTA TAAATGTGAA CTCCTCTTCC 
TTTCTGATGG TTCACAGAGC TGCCACAGAA CACCATGTGT GTGCAGATGG CTGGCAGGAG 
ATATTGAGTC AGCTGGCCTG CAAGCAGATG GGTTTAGGAG AACCATCTGT GACCAAATTG 
ATACAGGAAC AGGAGAAAGA GCCGCGGTGG CTGACATTAC ACTCCAACTG GGAGAGCCTC 
AATGGGACCA CTTTACATGA ACTTCTAGTA AATGGGCAGT CTTGTGAGAG CAGAAGTAAA 
ATTTCTCTTC TGTGTACTAA ACAAGACTGT GGGCGCCGCC CTGCTGCCCG AATGAACAAA 
AGGATCCTTG GAGGTCGGAC GAGTCGCCCT GGAAGGTGGC CATGGCAGTG TTCTCTGCAG 
AGTGAACCCA GTGGACATAT CTGTGGCTGT GTCCTCATTG CCAAGAAGTG GGTTCTGACA 
GTTGCCCACT GCTTCGAGGG GAGAGAGAAT GCTGCAGTTT GGAAAGTGGT GCTTGGCATC 
AACAATCTAG ACCATCCATC AGTGTTCATG CAGACACGCT TTGTGAAGAC CATCATCCTG 
CATCCCCGCT ACAGTCGAGC AGTGGTGGAC TATGACATCA GCATCGTTGA GCTGAGTGAA 
GACATCAGTG AGACTGGCTA CGTCCGGCCT GTCTGCTTGC CCAACCCGGA GCAGTGGCTA 
GAGCCTGACA CGTACTGCTA TATCACAGGC TGGGGCCACA TGGGCAATAA AATGCCATTT 
AAGCTGCAAG AGGGAGAGGT CCGCATTATT TCTCTGGAAC ATTGTCAGTC CTACTTTGAC 
ATGAAGACCA TCACCACTCG GATGATATGT GCTGGCTATG AGTCTGGCAC AGTTGATTCA 
TGCATGGGTG ACAGCGGTGG GCCTCTTGTT TGTGAGAAGC CTGGAGGACG GTGGACATTA 
TTTGGATTAA CTTCATGGGG CTCCGTCTGC TTTTCCAAAG TCCTGGGGCC TGGCGTTTAT 
AGTAATGTGT CATATTTCGT CGAATGGATT AAAAGACAGA TTTACATCCA GACCTTTCTC 
CTAAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CORIN ( NM_006587.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006578.2 Homo sapiens corin, serine peptidase (CORIN), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20561
Clone ID Related Accession (Same CDS sequence)	NM_006587.4 , NM_006587.3
Accession Version	NM_006587.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3129bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1514390400000
Organism	Homo sapiens(human)
Product	atrial natriuretic peptide-converting enzyme isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK304466.1, AF133845.1, AC092597.1 and AI378383.1. This sequence is a reference standard in the RefSeqGene project. On Jun 27, 2013 this sequence version replaced NM_006587.2. Transcript Variant: This variant (1) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF133845.1, BC110451.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAACAGT CTCCTGCCCT CGCTCCGGAA GAGCGCTGCC GCAGAGCCGG GTCCCCAAAG 
CCGGTCTTGA GAGCTGATGA CAATAACATG GGCAATGGCT GCTCTCAGAA GCTGGCGACT 
GCTAACCTCC TCCGGTTCCT ATTGCTGGTC CTGATTCCAT GTATCTGTGC TCTCGTTCTC 
TTGCTGGTGA TCCTGCTTTC CTATGTTGGA ACATTACAAA AGGTCTATTT TAAATCAAAT 
GGGAGTGAAC CTTTGGTCAC TGATGGTGAA ATCCAAGGGT CCGATGTTAT TCTTACAAAT 
ACAATTTATA ACCAGAGCAC TGTGGTGTCT ACTGCACATC CCGACCAACA CGTTCCAGCC 
TGGACTACGG ATGCTTCTCT CCCAGGGGAC CAAAGTCACA GGAATACAAG TGCCTGTATG 
AACATCACCC ACAGCCAGTG TCAGATGCTG CCCTACCACG CCACGCTGAC ACCTCTCCTC 
TCAGTTGTCA GAAACATGGA AATGGAAAAG TTCCTCAAGT TTTTCACATA TCTCCATCGC 
CTCAGTTGCT ATCAACATAT CATGCTGTTT GGCTGTACCC TCGCCTTCCC TGAGTGCATC 
ATTGATGGCG ATGACAGTCA TGGACTCCTG CCCTGTAGGT CCTTCTGTGA GGCTGCAAAA 
GAAGGCTGTG AATCAGTCCT GGGGATGGTG AATTACTCCT GGCCGGATTT CCTCAGATGC 
TCCCAGTTTA GAAACCAAAC TGAAAGCAGC AATGTCAGCA GAATTTGCTT CTCACCTCAG 
CAGGAAAACG GAAAGCAATT GCTCTGTGGA AGGGGTGAGA ACTTTCTGTG TGCCAGTGGA 
ATCTGCATCC CCGGGAAACT GCAATGTAAT GGCTACAACG ACTGTGACGA CTGGAGTGAC 
GAGGCTCATT GCAACTGCAG CGAGAATCTG TTTCACTGTC ACACAGGCAA GTGCCTTAAT 
TACAGCCTTG TGTGTGATGG ATATGATGAC TGTGGGGATT TGAGTGATGA GCAAAACTGT 
GATTGCAATC CCACAACAGA GCATCGCTGC GGGGACGGGC GCTGCATCGC CATGGAGTGG 
GTGTGTGATG GTGACCACGA CTGTGTGGAT AAGTCTGACG AGGTCAACTG CTCCTGTCAC 
AGCCAGGGTC TGGTGGAATG CAGAAATGGA CAATGTATCC CCAGCACGTT TCAATGTGAT 
GGTGACGAGG ACTGCAAGGA TGGGAGTGAT GAGGAGAACT GCAGCGTCAT TCAGACTTCA 
TGTCAAGAAG GAGACCAAAG ATGCCTCTAC AATCCCTGCC TTGATTCATG TGGTGGTAGC 
TCTCTCTGTG ACCCGAACAA CAGTCTGAAT AACTGTAGTC AATGTGAACC AATTACATTG 
GAACTCTGCA TGAATTTGCC CTACAACAGT ACAAGTTATC CAAATTATTT TGGCCACAGG 
ACTCAAAAGG AAGCATCCAT CAGCTGGGAG TCTTCTCTTT TCCCTGCACT TGTTCAAACC 
AACTGTTATA AATACCTCAT GTTCTTTTCT TGCACCATTT TGGTACCAAA ATGTGATGTG 
AATACAGGCG AGCATATCCC TCCTTGCAGG GCATTGTGTG AACACTCTAA AGAACGCTGT 
GAGTCTGTTC TTGGGATTGT GGGCCTACAG TGGCCTGAAG ACACAGATTG CAGTCAATTT 
CCAGAGGAAA ATTCAGACAA TCAAACCTGC CTGATGCCTG ATGAATATGT GGAAGAATGC 
TCACCTAGTC ATTTCAAGTG CCGCTCAGGA CAGTGTGTTC TGGCTTCCAG AAGATGTGAT 
GGCCAGGCCG ACTGTGACGA TGACAGTGAT GAGGAAAACT GTGGTTGTAA AGAGAGAGAT 
CTTTGGGAAT GTCCATCCAA TAAACAATGT TTGAAGCACA CAGTGATCTG CGATGGGTTC 
CCAGACTGCC CTGATTACAT GGACGAGAAA AACTGCTCAT TTTGCCAAGA TGATGAGCTG 
GAATGTGCAA ACCATGCGTG TGTGTCACGT GACCTGTGGT GTGATGGTGA AGCCGACTGC 
TCAGACAGTT CAGATGAATG GGACTGTGTG ACCCTCTCTA TAAATGTGAA CTCCTCTTCC 
TTTCTGATGG TTCACAGAGC TGCCACAGAA CACCATGTGT GTGCAGATGG CTGGCAGGAG 
ATATTGAGTC AGCTGGCCTG CAAGCAGATG GGTTTAGGAG AACCATCTGT GACCAAATTG 
ATACAGGAAC AGGAGAAAGA GCCGCGGTGG CTGACATTAC ACTCCAACTG GGAGAGCCTC 
AATGGGACCA CTTTACATGA ACTTCTAGTA AATGGGCAGT CTTGTGAGAG CAGAAGTAAA 
ATTTCTCTTC TGTGTACTAA ACAAGACTGT GGGCGCCGCC CTGCTGCCCG AATGAACAAA 
AGGATCCTTG GAGGTCGGAC GAGTCGCCCT GGAAGGTGGC CATGGCAGTG TTCTCTGCAG 
AGTGAACCCA GTGGACATAT CTGTGGCTGT GTCCTCATTG CCAAGAAGTG GGTTCTGACA 
GTTGCCCACT GCTTCGAGGG GAGAGAGAAT GCTGCAGTTT GGAAAGTGGT GCTTGGCATC 
AACAATCTAG ACCATCCATC AGTGTTCATG CAGACACGCT TTGTGAAGAC CATCATCCTG 
CATCCCCGCT ACAGTCGAGC AGTGGTGGAC TATGACATCA GCATCGTTGA GCTGAGTGAA 
GACATCAGTG AGACTGGCTA CGTCCGGCCT GTCTGCTTGC CCAACCCGGA GCAGTGGCTA 
GAGCCTGACA CGTACTGCTA TATCACAGGC TGGGGCCACA TGGGCAATAA AATGCCATTT 
AAGCTGCAAG AGGGAGAGGT CCGCATTATT TCTCTGGAAC ATTGTCAGTC CTACTTTGAC 
ATGAAGACCA TCACCACTCG GATGATATGT GCTGGCTATG AGTCTGGCAC AGTTGATTCA 
TGCATGGGTG ACAGCGGTGG GCCTCTTGTT TGTGAGAAGC CTGGAGGACG GTGGACATTA 
TTTGGATTAA CTTCATGGGG CTCCGTCTGC TTTTCCAAAG TCCTGGGGCC TGGCGTTTAT 
AGTAATGTGT CATATTTCGT CGAATGGATT AAAAGACAGA TTTACATCCA GACCTTTCTC 
CTAAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006578.2
CDS	158..3286
Translation	MKQSPALAPEERCRRAGSPKPVLRADDNNMGNGCSQKLATANLLRFLLLVLIPCICALVLLLVILLSYVGTLQKVYFKSNGSEPLVTDGEIQGSDVILTNTIYNQSTVVSTAHPDQHVPAWTTDASLPGDQSHRNTSACMNITHSQCQMLPYHATLTPLLSVVRNMEMEKFLKFFTYLHRLSCYQHIMLFGCTLAFPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVSRICFSPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVCADGWQEILSQLACKQMGLGEPSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQSCESRSKISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGRENAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDISETGYVRPVCLPNPEQWLEPDTYCYITGWGHMGNKMPFKLQEGEVRIISLEHCQSYFDMKTITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVYSNVSYFVEWIKRQIYIQTFLLN

Target ORF information:

RefSeq Version	NM_006587.3
Organism	Homo sapiens(human)
Definition	Homo sapiens corin, serine peptidase (CORIN), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006587.3

ORF Insert Sequence:

ATGAAACAGT CTCCTGCCCT CGCTCCGGAA GAGCGCTGCC GCAGAGCCGG GTCCCCAAAG 
CCGGTCTTGA GAGCTGATGA CAATAACATG GGCAATGGCT GCTCTCAGAA GCTGGCGACT 
GCTAACCTCC TCCGGTTCCT ATTGCTGGTC CTGATTCCAT GTATCTGTGC TCTCGTTCTC 
TTGCTGGTGA TCCTGCTTTC CTATGTTGGA ACATTACAAA AGGTCTATTT TAAATCAAAT 
GGGAGTGAAC CTTTGGTCAC TGATGGTGAA ATCCAAGGGT CCGATGTTAT TCTTACAAAT 
ACAATTTATA ACCAGAGCAC TGTGGTGTCT ACTGCACATC CCGACCAACA CGTTCCAGCC 
TGGACTACGG ATGCTTCTCT CCCAGGGGAC CAAAGTCACA GGAATACAAG TGCCTGTATG 
AACATCACCC ACAGCCAGTG TCAGATGCTG CCCTACCACG CCACGCTGAC ACCTCTCCTC 
TCAGTTGTCA GAAACATGGA AATGGAAAAG TTCCTCAAGT TTTTCACATA TCTCCATCGC 
CTCAGTTGCT ATCAACATAT CATGCTGTTT GGCTGTACCC TCGCCTTCCC TGAGTGCATC 
ATTGATGGCG ATGACAGTCA TGGACTCCTG CCCTGTAGGT CCTTCTGTGA GGCTGCAAAA 
GAAGGCTGTG AATCAGTCCT GGGGATGGTG AATTACTCCT GGCCGGATTT CCTCAGATGC 
TCCCAGTTTA GAAACCAAAC TGAAAGCAGC AATGTCAGCA GAATTTGCTT CTCACCTCAG 
CAGGAAAACG GAAAGCAATT GCTCTGTGGA AGGGGTGAGA ACTTTCTGTG TGCCAGTGGA 
ATCTGCATCC CCGGGAAACT GCAATGTAAT GGCTACAACG ACTGTGACGA CTGGAGTGAC 
GAGGCTCATT GCAACTGCAG CGAGAATCTG TTTCACTGTC ACACAGGCAA GTGCCTTAAT 
TACAGCCTTG TGTGTGATGG ATATGATGAC TGTGGGGATT TGAGTGATGA GCAAAACTGT 
GATTGCAATC CCACAACAGA GCATCGCTGC GGGGACGGGC GCTGCATCGC CATGGAGTGG 
GTGTGTGATG GTGACCACGA CTGTGTGGAT AAGTCTGACG AGGTCAACTG CTCCTGTCAC 
AGCCAGGGTC TGGTGGAATG CAGAAATGGA CAATGTATCC CCAGCACGTT TCAATGTGAT 
GGTGACGAGG ACTGCAAGGA TGGGAGTGAT GAGGAGAACT GCAGCGTCAT TCAGACTTCA 
TGTCAAGAAG GAGACCAAAG ATGCCTCTAC AATCCCTGCC TTGATTCATG TGGTGGTAGC 
TCTCTCTGTG ACCCGAACAA CAGTCTGAAT AACTGTAGTC AATGTGAACC AATTACATTG 
GAACTCTGCA TGAATTTGCC CTACAACAGT ACAAGTTATC CAAATTATTT TGGCCACAGG 
ACTCAAAAGG AAGCATCCAT CAGCTGGGAG TCTTCTCTTT TCCCTGCACT TGTTCAAACC 
AACTGTTATA AATACCTCAT GTTCTTTTCT TGCACCATTT TGGTACCAAA ATGTGATGTG 
AATACAGGCG AGCATATCCC TCCTTGCAGG GCATTGTGTG AACACTCTAA AGAACGCTGT 
GAGTCTGTTC TTGGGATTGT GGGCCTACAG TGGCCTGAAG ACACAGATTG CAGTCAATTT 
CCAGAGGAAA ATTCAGACAA TCAAACCTGC CTGATGCCTG ATGAATATGT GGAAGAATGC 
TCACCTAGTC ATTTCAAGTG CCGCTCAGGA CAGTGTGTTC TGGCTTCCAG AAGATGTGAT 
GGCCAGGCCG ACTGTGACGA TGACAGTGAT GAGGAAAACT GTGGTTGTAA AGAGAGAGAT 
CTTTGGGAAT GTCCATCCAA TAAACAATGT TTGAAGCACA CAGTGATCTG CGATGGGTTC 
CCAGACTGCC CTGATTACAT GGACGAGAAA AACTGCTCAT TTTGCCAAGA TGATGAGCTG 
GAATGTGCAA ACCATGCGTG TGTGTCACGT GACCTGTGGT GTGATGGTGA AGCCGACTGC 
TCAGACAGTT CAGATGAATG GGACTGTGTG ACCCTCTCTA TAAATGTGAA CTCCTCTTCC 
TTTCTGATGG TTCACAGAGC TGCCACAGAA CACCATGTGT GTGCAGATGG CTGGCAGGAG 
ATATTGAGTC AGCTGGCCTG CAAGCAGATG GGTTTAGGAG AACCATCTGT GACCAAATTG 
ATACAGGAAC AGGAGAAAGA GCCGCGGTGG CTGACATTAC ACTCCAACTG GGAGAGCCTC 
AATGGGACCA CTTTACATGA ACTTCTAGTA AATGGGCAGT CTTGTGAGAG CAGAAGTAAA 
ATTTCTCTTC TGTGTACTAA ACAAGACTGT GGGCGCCGCC CTGCTGCCCG AATGAACAAA 
AGGATCCTTG GAGGTCGGAC GAGTCGCCCT GGAAGGTGGC CATGGCAGTG TTCTCTGCAG 
AGTGAACCCA GTGGACATAT CTGTGGCTGT GTCCTCATTG CCAAGAAGTG GGTTCTGACA 
GTTGCCCACT GCTTCGAGGG GAGAGAGAAT GCTGCAGTTT GGAAAGTGGT GCTTGGCATC 
AACAATCTAG ACCATCCATC AGTGTTCATG CAGACACGCT TTGTGAAGAC CATCATCCTG 
CATCCCCGCT ACAGTCGAGC AGTGGTGGAC TATGACATCA GCATCGTTGA GCTGAGTGAA 
GACATCAGTG AGACTGGCTA CGTCCGGCCT GTCTGCTTGC CCAACCCGGA GCAGTGGCTA 
GAGCCTGACA CGTACTGCTA TATCACAGGC TGGGGCCACA TGGGCAATAA AATGCCATTT 
AAGCTGCAAG AGGGAGAGGT CCGCATTATT TCTCTGGAAC ATTGTCAGTC CTACTTTGAC 
ATGAAGACCA TCACCACTCG GATGATATGT GCTGGCTATG AGTCTGGCAC AGTTGATTCA 
TGCATGGGTG ACAGCGGTGG GCCTCTTGTT TGTGAGAAGC CTGGAGGACG GTGGACATTA 
TTTGGATTAA CTTCATGGGG CTCCGTCTGC TTTTCCAAAG TCCTGGGGCC TGGCGTTTAT 
AGTAATGTGT CATATTTCGT CGAATGGATT AAAAGACAGA TTTACATCCA GACCTTTCTC 
CTAAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CORIN ( NM_001278586.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001265515.1 Homo sapiens corin, serine peptidase (CORIN), transcript variant 3, mRNA.

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CloneID	OHu14294
Clone ID Related Accession (Same CDS sequence)	NM_001278586.2 , NM_001278586.1
Accession Version	NM_001278586.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2205bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1574611200000
Organism	Homo sapiens(human)
Product	atrial natriuretic peptide-converting enzyme isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK304466.1 and AI338960.1. On May 31, 2019 this sequence version replaced NM_001278586.1. Transcript Variant: This variant (3) lacks an in-frame internal exon and multiple 3' terminal exons, and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The resulting isoform (3) is shorter; it lacks an internal segment and has a distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK304466.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGAAACAGT CTCCTGCCCT CGCTCCGGAA GAGCGCTGCC GCAGAGCCGG GTCCCCAAAG 
CCGGTCTTGA GAGCTGATGA CAATAACATG GGCAATGGCT GCTCTCAGAA GCTGGCGACT 
GCTAACCTCC TCCGGTTCCT ATTGCTGGTC CTGATTCCAT GTATCTGTGC TCTCGTTCTC 
TTGCTGGTGA TCCTGCTTTC CTATGTTGGA ACATTACAAA AGGTCTATTT TAAATCAAAT 
GGGAGTGAAC CTTTGGTCAC TGATGGTGAA ATCCAAGGGT CCGATGTTAT TCTTACAAAT 
ACAATTTATA ACCAGAGCAC TGTGGTGTCT ACTGCACATC CCGACCAACA CGTTCCAGCC 
TGGACTACGG ATGCTTCTCT CCCAGGGGAC CAAAGTCACA GGAATACAAG TGCCTGTATG 
AACATCACCC ACAGCCAGTG TCAGATGCTG CCCTACCACG CCACGCTGAC ACCTCTCCTC 
TCAGTTGTCA GAAACATGGA AATGGAAAAG TTCCTCAAGT TTTTCACATA TCTCCATCGC 
CTCAGTTGCT ATCAACATAT CATGCTGTTT GGCTGTACCC TCGCCTTCCC TGAGTGCATC 
ATTGATGGCG ATGACAGTCA TGGACTCCTG CCCTGTAGGT CCTTCTGTGA GGCTGCAAAA 
GAAGGCTGTG AATCAGTCCT GGGGATGGTG AATTACTCCT GGCCGGATTT CCTCAGATGC 
TCCCAGTTTA GAAACCAAAC TGAAAGCAGC AATGTCAGCA GAATTTGCTT CTCACCTCAG 
CAGGAAAACG GAAAGCAATT GCTCTGTGGA AGGGGTGAGA ACTTTCTGTG TGCCAGTGGA 
ATCTGCATCC CCGGGAAACT GCAATGTAAT GGCTACAACG ACTGTGACGA CTGGAGTGAC 
GAGGCTCATT GCAACTGCAG CGAGAATCTG TTTCACTGTC ACACAGGCAA GTGCCTTAAT 
TACAGCCTTG TGTGTGATGG ATATGATGAC TGTGGGGATT TGAGTGATGA GCAAAACTGT 
GCCTGTCACA GCCAGGGTCT GGTGGAATGC AGAAATGGAC AATGTATCCC CAGCACGTTT 
CAATGTGATG GTGACGAGGA CTGCAAGGAT GGGAGTGATG AGGAGAACTG CAGCGTCATT 
CAGACTTCAT GTCAAGAAGG AGACCAAAGA TGCCTCTACA ATCCCTGCCT TGATTCATGT 
GGTGGTAGCT CTCTCTGTGA CCCGAACAAC AGTCTGAATA ACTGTAGTCA ATGTGAACCA 
ATTACATTGG AACTCTGCAT GAATTTGCCC TACAACAGTA CAAGTTATCC AAATTATTTT 
GGCCACAGGA CTCAAAAGGA AGCATCCATC AGCTGGGAGT CTTCTCTTTT CCCTGCACTT 
GTTCAAACCA ACTGTTATAA ATACCTCATG TTCTTTTCTT GCACCATTTT GGTACCAAAA 
TGTGATGTGA ATACAGGCGA GCATATCCCT CCTTGCAGGG CATTGTGTGA ACACTCTAAA 
GAACGCTGTG AGTCTGTTCT TGGGATTGTG GGCCTACAGT GGCCTGAAGA CACAGATTGC 
AGTCAATTTC CAGAGGAAAA TTCAGACAAT CAAACCTGCC TGATGCCTGA TGAATATGTG 
GAAGAATGCT CACCTAGTCA TTTCAAGTGC CGCTCAGGAC AGTGTGTTCT GGCTTCCAGA 
AGATGTGATG GCCAGGCCGA CTGTGACGAT GACAGTGATG AGGAAAACTG TGGTTGTAAA 
GAGAGAGATC TTTGGGAATG TCCATCCAAT AAACAATGTT TGAAGCACAC AGTGATCTGC 
GATGGGTTCC CAGACTGCCC TGATTACATG GACGAGAAAA ACTGCTCATT TTGCCAAGAT 
GATGAGCTGG AATGTGCAAA CCATGCGTGT GTGTCACGTG ACCTGTGGTG TGATGGTGAA 
GCCGACTGCT CAGACAGTTC AGATGAATGG GACTGTGGTG AGCTACTTGT TTCTGCCATC 
TGTTGTACTC TCTCATGCCT GTCAGCCACT GAAGCTGAAT GGATCCTAAA TTACTTCCTG 
GATTTTACTG ACCAAGTTCA TCTATTTTGT TTTACTGTTA TAAAAGCTGA TAGTGCTGAT 
CTATGTGTGT TATTTCCAAC TCACAGAAAA TTTCCCCACG AAGCTACTTC TCTATTTGAA 
ATATCTATAT TGTATGGAAA AACGTTTGGG TTCAAAATGT TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265515.1
CDS	119..2323
Translation	MKQSPALAPEERCRRAGSPKPVLRADDNNMGNGCSQKLATANLLRFLLLVLIPCICALVLLLVILLSYVGTLQKVYFKSNGSEPLVTDGEIQGSDVILTNTIYNQSTVVSTAHPDQHVPAWTTDASLPGDQSHRNTSACMNITHSQCQMLPYHATLTPLLSVVRNMEMEKFLKFFTYLHRLSCYQHIMLFGCTLAFPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVSRICFSPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCACHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCGELLVSAICCTLSCLSATEAEWILNYFLDFTDQVHLFCFTVIKADSADLCVLFPTHRKFPHEATSLFEISILYGKTFGFKML

Target ORF information:

RefSeq Version	NM_001278586.2
Organism	Homo sapiens(human)
Definition	Homo sapiens corin, serine peptidase (CORIN), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278586.2

ORF Insert Sequence:

ATGAAACAGT CTCCTGCCCT CGCTCCGGAA GAGCGCTGCC GCAGAGCCGG GTCCCCAAAG 
CCGGTCTTGA GAGCTGATGA CAATAACATG GGCAATGGCT GCTCTCAGAA GCTGGCGACT 
GCTAACCTCC TCCGGTTCCT ATTGCTGGTC CTGATTCCAT GTATCTGTGC TCTCGTTCTC 
TTGCTGGTGA TCCTGCTTTC CTATGTTGGA ACATTACAAA AGGTCTATTT TAAATCAAAT 
GGGAGTGAAC CTTTGGTCAC TGATGGTGAA ATCCAAGGGT CCGATGTTAT TCTTACAAAT 
ACAATTTATA ACCAGAGCAC TGTGGTGTCT ACTGCACATC CCGACCAACA CGTTCCAGCC 
TGGACTACGG ATGCTTCTCT CCCAGGGGAC CAAAGTCACA GGAATACAAG TGCCTGTATG 
AACATCACCC ACAGCCAGTG TCAGATGCTG CCCTACCACG CCACGCTGAC ACCTCTCCTC 
TCAGTTGTCA GAAACATGGA AATGGAAAAG TTCCTCAAGT TTTTCACATA TCTCCATCGC 
CTCAGTTGCT ATCAACATAT CATGCTGTTT GGCTGTACCC TCGCCTTCCC TGAGTGCATC 
ATTGATGGCG ATGACAGTCA TGGACTCCTG CCCTGTAGGT CCTTCTGTGA GGCTGCAAAA 
GAAGGCTGTG AATCAGTCCT GGGGATGGTG AATTACTCCT GGCCGGATTT CCTCAGATGC 
TCCCAGTTTA GAAACCAAAC TGAAAGCAGC AATGTCAGCA GAATTTGCTT CTCACCTCAG 
CAGGAAAACG GAAAGCAATT GCTCTGTGGA AGGGGTGAGA ACTTTCTGTG TGCCAGTGGA 
ATCTGCATCC CCGGGAAACT GCAATGTAAT GGCTACAACG ACTGTGACGA CTGGAGTGAC 
GAGGCTCATT GCAACTGCAG CGAGAATCTG TTTCACTGTC ACACAGGCAA GTGCCTTAAT 
TACAGCCTTG TGTGTGATGG ATATGATGAC TGTGGGGATT TGAGTGATGA GCAAAACTGT 
GCCTGTCACA GCCAGGGTCT GGTGGAATGC AGAAATGGAC AATGTATCCC CAGCACGTTT 
CAATGTGATG GTGACGAGGA CTGCAAGGAT GGGAGTGATG AGGAGAACTG CAGCGTCATT 
CAGACTTCAT GTCAAGAAGG AGACCAAAGA TGCCTCTACA ATCCCTGCCT TGATTCATGT 
GGTGGTAGCT CTCTCTGTGA CCCGAACAAC AGTCTGAATA ACTGTAGTCA ATGTGAACCA 
ATTACATTGG AACTCTGCAT GAATTTGCCC TACAACAGTA CAAGTTATCC AAATTATTTT 
GGCCACAGGA CTCAAAAGGA AGCATCCATC AGCTGGGAGT CTTCTCTTTT CCCTGCACTT 
GTTCAAACCA ACTGTTATAA ATACCTCATG TTCTTTTCTT GCACCATTTT GGTACCAAAA 
TGTGATGTGA ATACAGGCGA GCATATCCCT CCTTGCAGGG CATTGTGTGA ACACTCTAAA 
GAACGCTGTG AGTCTGTTCT TGGGATTGTG GGCCTACAGT GGCCTGAAGA CACAGATTGC 
AGTCAATTTC CAGAGGAAAA TTCAGACAAT CAAACCTGCC TGATGCCTGA TGAATATGTG 
GAAGAATGCT CACCTAGTCA TTTCAAGTGC CGCTCAGGAC AGTGTGTTCT GGCTTCCAGA 
AGATGTGATG GCCAGGCCGA CTGTGACGAT GACAGTGATG AGGAAAACTG TGGTTGTAAA 
GAGAGAGATC TTTGGGAATG TCCATCCAAT AAACAATGTT TGAAGCACAC AGTGATCTGC 
GATGGGTTCC CAGACTGCCC TGATTACATG GACGAGAAAA ACTGCTCATT TTGCCAAGAT 
GATGAGCTGG AATGTGCAAA CCATGCGTGT GTGTCACGTG ACCTGTGGTG TGATGGTGAA 
GCCGACTGCT CAGACAGTTC AGATGAATGG GACTGTGGTG AGCTACTTGT TTCTGCCATC 
TGTTGTACTC TCTCATGCCT GTCAGCCACT GAAGCTGAAT GGATCCTAAA TTACTTCCTG 
GATTTTACTG ACCAAGTTCA TCTATTTTGT TTTACTGTTA TAAAAGCTGA TAGTGCTGAT 
CTATGTGTGT TATTTCCAAC TCACAGAAAA TTTCCCCACG AAGCTACTTC TCTATTTGAA 
ATATCTATAT TGTATGGAAA AACGTTTGGG TTCAAAATGT TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CORIN ( NM_001278586.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001265515.1 Homo sapiens corin, serine peptidase (CORIN), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu14294
Clone ID Related Accession (Same CDS sequence)	NM_001278586.2 , NM_001278586.1
Accession Version	NM_001278586.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2205bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550851200000
Organism	Homo sapiens(human)
Product	atrial natriuretic peptide-converting enzyme isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK304466.1 and AI338960.1. Transcript Variant: This variant (3) lacks an in-frame internal exon and multiple 3' terminal exons, and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The resulting isoform (3) is shorter; it lacks an internal segment and has a distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK304466.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGAAACAGT CTCCTGCCCT CGCTCCGGAA GAGCGCTGCC GCAGAGCCGG GTCCCCAAAG 
CCGGTCTTGA GAGCTGATGA CAATAACATG GGCAATGGCT GCTCTCAGAA GCTGGCGACT 
GCTAACCTCC TCCGGTTCCT ATTGCTGGTC CTGATTCCAT GTATCTGTGC TCTCGTTCTC 
TTGCTGGTGA TCCTGCTTTC CTATGTTGGA ACATTACAAA AGGTCTATTT TAAATCAAAT 
GGGAGTGAAC CTTTGGTCAC TGATGGTGAA ATCCAAGGGT CCGATGTTAT TCTTACAAAT 
ACAATTTATA ACCAGAGCAC TGTGGTGTCT ACTGCACATC CCGACCAACA CGTTCCAGCC 
TGGACTACGG ATGCTTCTCT CCCAGGGGAC CAAAGTCACA GGAATACAAG TGCCTGTATG 
AACATCACCC ACAGCCAGTG TCAGATGCTG CCCTACCACG CCACGCTGAC ACCTCTCCTC 
TCAGTTGTCA GAAACATGGA AATGGAAAAG TTCCTCAAGT TTTTCACATA TCTCCATCGC 
CTCAGTTGCT ATCAACATAT CATGCTGTTT GGCTGTACCC TCGCCTTCCC TGAGTGCATC 
ATTGATGGCG ATGACAGTCA TGGACTCCTG CCCTGTAGGT CCTTCTGTGA GGCTGCAAAA 
GAAGGCTGTG AATCAGTCCT GGGGATGGTG AATTACTCCT GGCCGGATTT CCTCAGATGC 
TCCCAGTTTA GAAACCAAAC TGAAAGCAGC AATGTCAGCA GAATTTGCTT CTCACCTCAG 
CAGGAAAACG GAAAGCAATT GCTCTGTGGA AGGGGTGAGA ACTTTCTGTG TGCCAGTGGA 
ATCTGCATCC CCGGGAAACT GCAATGTAAT GGCTACAACG ACTGTGACGA CTGGAGTGAC 
GAGGCTCATT GCAACTGCAG CGAGAATCTG TTTCACTGTC ACACAGGCAA GTGCCTTAAT 
TACAGCCTTG TGTGTGATGG ATATGATGAC TGTGGGGATT TGAGTGATGA GCAAAACTGT 
GCCTGTCACA GCCAGGGTCT GGTGGAATGC AGAAATGGAC AATGTATCCC CAGCACGTTT 
CAATGTGATG GTGACGAGGA CTGCAAGGAT GGGAGTGATG AGGAGAACTG CAGCGTCATT 
CAGACTTCAT GTCAAGAAGG AGACCAAAGA TGCCTCTACA ATCCCTGCCT TGATTCATGT 
GGTGGTAGCT CTCTCTGTGA CCCGAACAAC AGTCTGAATA ACTGTAGTCA ATGTGAACCA 
ATTACATTGG AACTCTGCAT GAATTTGCCC TACAACAGTA CAAGTTATCC AAATTATTTT 
GGCCACAGGA CTCAAAAGGA AGCATCCATC AGCTGGGAGT CTTCTCTTTT CCCTGCACTT 
GTTCAAACCA ACTGTTATAA ATACCTCATG TTCTTTTCTT GCACCATTTT GGTACCAAAA 
TGTGATGTGA ATACAGGCGA GCATATCCCT CCTTGCAGGG CATTGTGTGA ACACTCTAAA 
GAACGCTGTG AGTCTGTTCT TGGGATTGTG GGCCTACAGT GGCCTGAAGA CACAGATTGC 
AGTCAATTTC CAGAGGAAAA TTCAGACAAT CAAACCTGCC TGATGCCTGA TGAATATGTG 
GAAGAATGCT CACCTAGTCA TTTCAAGTGC CGCTCAGGAC AGTGTGTTCT GGCTTCCAGA 
AGATGTGATG GCCAGGCCGA CTGTGACGAT GACAGTGATG AGGAAAACTG TGGTTGTAAA 
GAGAGAGATC TTTGGGAATG TCCATCCAAT AAACAATGTT TGAAGCACAC AGTGATCTGC 
GATGGGTTCC CAGACTGCCC TGATTACATG GACGAGAAAA ACTGCTCATT TTGCCAAGAT 
GATGAGCTGG AATGTGCAAA CCATGCGTGT GTGTCACGTG ACCTGTGGTG TGATGGTGAA 
GCCGACTGCT CAGACAGTTC AGATGAATGG GACTGTGGTG AGCTACTTGT TTCTGCCATC 
TGTTGTACTC TCTCATGCCT GTCAGCCACT GAAGCTGAAT GGATCCTAAA TTACTTCCTG 
GATTTTACTG ACCAAGTTCA TCTATTTTGT TTTACTGTTA TAAAAGCTGA TAGTGCTGAT 
CTATGTGTGT TATTTCCAAC TCACAGAAAA TTTCCCCACG AAGCTACTTC TCTATTTGAA 
ATATCTATAT TGTATGGAAA AACGTTTGGG TTCAAAATGT TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265515.1
CDS	158..2362
Translation	MKQSPALAPEERCRRAGSPKPVLRADDNNMGNGCSQKLATANLLRFLLLVLIPCICALVLLLVILLSYVGTLQKVYFKSNGSEPLVTDGEIQGSDVILTNTIYNQSTVVSTAHPDQHVPAWTTDASLPGDQSHRNTSACMNITHSQCQMLPYHATLTPLLSVVRNMEMEKFLKFFTYLHRLSCYQHIMLFGCTLAFPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVSRICFSPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCACHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCGELLVSAICCTLSCLSATEAEWILNYFLDFTDQVHLFCFTVIKADSADLCVLFPTHRKFPHEATSLFEISILYGKTFGFKML

Target ORF information:

RefSeq Version	NM_001278586.1
Organism	Homo sapiens(human)
Definition	Homo sapiens corin, serine peptidase (CORIN), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278586.1

ORF Insert Sequence:

ATGAAACAGT CTCCTGCCCT CGCTCCGGAA GAGCGCTGCC GCAGAGCCGG GTCCCCAAAG 
CCGGTCTTGA GAGCTGATGA CAATAACATG GGCAATGGCT GCTCTCAGAA GCTGGCGACT 
GCTAACCTCC TCCGGTTCCT ATTGCTGGTC CTGATTCCAT GTATCTGTGC TCTCGTTCTC 
TTGCTGGTGA TCCTGCTTTC CTATGTTGGA ACATTACAAA AGGTCTATTT TAAATCAAAT 
GGGAGTGAAC CTTTGGTCAC TGATGGTGAA ATCCAAGGGT CCGATGTTAT TCTTACAAAT 
ACAATTTATA ACCAGAGCAC TGTGGTGTCT ACTGCACATC CCGACCAACA CGTTCCAGCC 
TGGACTACGG ATGCTTCTCT CCCAGGGGAC CAAAGTCACA GGAATACAAG TGCCTGTATG 
AACATCACCC ACAGCCAGTG TCAGATGCTG CCCTACCACG CCACGCTGAC ACCTCTCCTC 
TCAGTTGTCA GAAACATGGA AATGGAAAAG TTCCTCAAGT TTTTCACATA TCTCCATCGC 
CTCAGTTGCT ATCAACATAT CATGCTGTTT GGCTGTACCC TCGCCTTCCC TGAGTGCATC 
ATTGATGGCG ATGACAGTCA TGGACTCCTG CCCTGTAGGT CCTTCTGTGA GGCTGCAAAA 
GAAGGCTGTG AATCAGTCCT GGGGATGGTG AATTACTCCT GGCCGGATTT CCTCAGATGC 
TCCCAGTTTA GAAACCAAAC TGAAAGCAGC AATGTCAGCA GAATTTGCTT CTCACCTCAG 
CAGGAAAACG GAAAGCAATT GCTCTGTGGA AGGGGTGAGA ACTTTCTGTG TGCCAGTGGA 
ATCTGCATCC CCGGGAAACT GCAATGTAAT GGCTACAACG ACTGTGACGA CTGGAGTGAC 
GAGGCTCATT GCAACTGCAG CGAGAATCTG TTTCACTGTC ACACAGGCAA GTGCCTTAAT 
TACAGCCTTG TGTGTGATGG ATATGATGAC TGTGGGGATT TGAGTGATGA GCAAAACTGT 
GCCTGTCACA GCCAGGGTCT GGTGGAATGC AGAAATGGAC AATGTATCCC CAGCACGTTT 
CAATGTGATG GTGACGAGGA CTGCAAGGAT GGGAGTGATG AGGAGAACTG CAGCGTCATT 
CAGACTTCAT GTCAAGAAGG AGACCAAAGA TGCCTCTACA ATCCCTGCCT TGATTCATGT 
GGTGGTAGCT CTCTCTGTGA CCCGAACAAC AGTCTGAATA ACTGTAGTCA ATGTGAACCA 
ATTACATTGG AACTCTGCAT GAATTTGCCC TACAACAGTA CAAGTTATCC AAATTATTTT 
GGCCACAGGA CTCAAAAGGA AGCATCCATC AGCTGGGAGT CTTCTCTTTT CCCTGCACTT 
GTTCAAACCA ACTGTTATAA ATACCTCATG TTCTTTTCTT GCACCATTTT GGTACCAAAA 
TGTGATGTGA ATACAGGCGA GCATATCCCT CCTTGCAGGG CATTGTGTGA ACACTCTAAA 
GAACGCTGTG AGTCTGTTCT TGGGATTGTG GGCCTACAGT GGCCTGAAGA CACAGATTGC 
AGTCAATTTC CAGAGGAAAA TTCAGACAAT CAAACCTGCC TGATGCCTGA TGAATATGTG 
GAAGAATGCT CACCTAGTCA TTTCAAGTGC CGCTCAGGAC AGTGTGTTCT GGCTTCCAGA 
AGATGTGATG GCCAGGCCGA CTGTGACGAT GACAGTGATG AGGAAAACTG TGGTTGTAAA 
GAGAGAGATC TTTGGGAATG TCCATCCAAT AAACAATGTT TGAAGCACAC AGTGATCTGC 
GATGGGTTCC CAGACTGCCC TGATTACATG GACGAGAAAA ACTGCTCATT TTGCCAAGAT 
GATGAGCTGG AATGTGCAAA CCATGCGTGT GTGTCACGTG ACCTGTGGTG TGATGGTGAA 
GCCGACTGCT CAGACAGTTC AGATGAATGG GACTGTGGTG AGCTACTTGT TTCTGCCATC 
TGTTGTACTC TCTCATGCCT GTCAGCCACT GAAGCTGAAT GGATCCTAAA TTACTTCCTG 
GATTTTACTG ACCAAGTTCA TCTATTTTGT TTTACTGTTA TAAAAGCTGA TAGTGCTGAT 
CTATGTGTGT TATTTCCAAC TCACAGAAAA TTTCCCCACG AAGCTACTTC TCTATTTGAA 
ATATCTATAT TGTATGGAAA AACGTTTGGG TTCAAAATGT TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CORIN ( NM_001278585.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001265514.1 Homo sapiens corin, serine peptidase (CORIN), transcript variant 2, mRNA.

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CloneID	OHu14763
Clone ID Related Accession (Same CDS sequence)	NM_001278585.1
Accession Version	NM_001278585.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2817bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1574611200000
Organism	Homo sapiens(human)
Product	atrial natriuretic peptide-converting enzyme isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK304466.1, AK304038.1, AF133845.1 and AI378383.1. Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. The resulting isoform (2) lacks two internal segments, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGAAACAGT CTCCTGCCCT CGCTCCGGAA GAGCGCTGCC GCAGAGCCGG GTCCCCAAAG 
CCGGTCTTGA GAGCTGATGA CAATAACATG GGCAATGGCT GCTCTCAGAA GCTGGCGACT 
GCTAACCTCC TCCGGTTCCT ATTGCTGGTC CTGATTCCAT GTATCTGTGC TCTCGTTCTC 
TTGCTGGTGA TCCTGCTTTC CTATGTTGGT GCCTGTATGA ACATCACCCA CAGCCAGTGT 
CAGATGCTGC CCTACCACGC CACGCTGACA CCTCTCCTCT CAGTTGTCAG AAACATGGAA 
ATGGAAAAGT TCCTCAAGTT TTTCACATAT CTCCATCGCC TCAGTTGCTA TCAACATATC 
ATGCTGTTTG GCTGTACCCT CGCCTTCCCT GAGTGCATCA TTGATGGCGA TGACAGTCAT 
GGACTCCTGC CCTGTAGGTC CTTCTGTGAG GCTGCAAAAG AAGGCTGTGA ATCAGTCCTG 
GGGATGGTGA ATTACTCCTG GCCGGATTTC CTCAGATGCT CCCAGTTTAG AAACCAAACT 
GAAAGCAGCA ATGTCAGCAG AATTTGCTTC TCACCTCAGC AGGAAAACGG AAAGCAATTG 
CTCTGTGGAA GGGGTGAGAA CTTTCTGTGT GCCAGTGGAA TCTGCATCCC CGGGAAACTG 
CAATGTAATG GCTACAACGA CTGTGACGAC TGGAGTGACG AGGCTCATTG CAACTGCAGC 
GAGAATCTGT TTCACTGTCA CACAGGCAAG TGCCTTAATT ACAGCCTTGT GTGTGATGGA 
TATGATGACT GTGGGGATTT GAGTGATGAG CAAAACTGTG CCTGTCACAG CCAGGGTCTG 
GTGGAATGCA GAAATGGACA ATGTATCCCC AGCACGTTTC AATGTGATGG TGACGAGGAC 
TGCAAGGATG GGAGTGATGA GGAGAACTGC AGCGTCATTC AGACTTCATG TCAAGAAGGA 
GACCAAAGAT GCCTCTACAA TCCCTGCCTT GATTCATGTG GTGGTAGCTC TCTCTGTGAC 
CCGAACAACA GTCTGAATAA CTGTAGTCAA TGTGAACCAA TTACATTGGA ACTCTGCATG 
AATTTGCCCT ACAACAGTAC AAGTTATCCA AATTATTTTG GCCACAGGAC TCAAAAGGAA 
GCATCCATCA GCTGGGAGTC TTCTCTTTTC CCTGCACTTG TTCAAACCAA CTGTTATAAA 
TACCTCATGT TCTTTTCTTG CACCATTTTG GTACCAAAAT GTGATGTGAA TACAGGCGAG 
CATATCCCTC CTTGCAGGGC ATTGTGTGAA CACTCTAAAG AACGCTGTGA GTCTGTTCTT 
GGGATTGTGG GCCTACAGTG GCCTGAAGAC ACAGATTGCA GTCAATTTCC AGAGGAAAAT 
TCAGACAATC AAACCTGCCT GATGCCTGAT GAATATGTGG AAGAATGCTC ACCTAGTCAT 
TTCAAGTGCC GCTCAGGACA GTGTGTTCTG GCTTCCAGAA GATGTGATGG CCAGGCCGAC 
TGTGACGATG ACAGTGATGA GGAAAACTGT GGTTGTAAAG AGAGAGATCT TTGGGAATGT 
CCATCCAATA AACAATGTTT GAAGCACACA GTGATCTGCG ATGGGTTCCC AGACTGCCCT 
GATTACATGG ACGAGAAAAA CTGCTCATTT TGCCAAGATG ATGAGCTGGA ATGTGCAAAC 
CATGCGTGTG TGTCACGTGA CCTGTGGTGT GATGGTGAAG CCGACTGCTC AGACAGTTCA 
GATGAATGGG ACTGTGTGAC CCTCTCTATA AATGTGAACT CCTCTTCCTT TCTGATGGTT 
CACAGAGCTG CCACAGAACA CCATGTGTGT GCAGATGGCT GGCAGGAGAT ATTGAGTCAG 
CTGGCCTGCA AGCAGATGGG TTTAGGAGAA CCATCTGTGA CCAAATTGAT ACAGGAACAG 
GAGAAAGAGC CGCGGTGGCT GACATTACAC TCCAACTGGG AGAGCCTCAA TGGGACCACT 
TTACATGAAC TTCTAGTAAA TGGGCAGTCT TGTGAGAGCA GAAGTAAAAT TTCTCTTCTG 
TGTACTAAAC AAGACTGTGG GCGCCGCCCT GCTGCCCGAA TGAACAAAAG GATCCTTGGA 
GGTCGGACGA GTCGCCCTGG AAGGTGGCCA TGGCAGTGTT CTCTGCAGAG TGAACCCAGT 
GGACATATCT GTGGCTGTGT CCTCATTGCC AAGAAGTGGG TTCTGACAGT TGCCCACTGC 
TTCGAGGGGA GAGAGAATGC TGCAGTTTGG AAAGTGGTGC TTGGCATCAA CAATCTAGAC 
CATCCATCAG TGTTCATGCA GACACGCTTT GTGAAGACCA TCATCCTGCA TCCCCGCTAC 
AGTCGAGCAG TGGTGGACTA TGACATCAGC ATCGTTGAGC TGAGTGAAGA CATCAGTGAG 
ACTGGCTACG TCCGGCCTGT CTGCTTGCCC AACCCGGAGC AGTGGCTAGA GCCTGACACG 
TACTGCTATA TCACAGGCTG GGGCCACATG GGCAATAAAA TGCCATTTAA GCTGCAAGAG 
GGAGAGGTCC GCATTATTTC TCTGGAACAT TGTCAGTCCT ACTTTGACAT GAAGACCATC 
ACCACTCGGA TGATATGTGC TGGCTATGAG TCTGGCACAG TTGATTCATG CATGGGTGAC 
AGCGGTGGGC CTCTTGTTTG TGAGAAGCCT GGAGGACGGT GGACATTATT TGGATTAACT 
TCATGGGGCT CCGTCTGCTT TTCCAAAGTC CTGGGGCCTG GCGTTTATAG TAATGTGTCA 
TATTTCGTCG AATGGATTAA AAGACAGATT TACATCCAGA CCTTTCTCCT AAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001265514.1
CDS	158..2974
Translation	MKQSPALAPEERCRRAGSPKPVLRADDNNMGNGCSQKLATANLLRFLLLVLIPCICALVLLLVILLSYVGACMNITHSQCQMLPYHATLTPLLSVVRNMEMEKFLKFFTYLHRLSCYQHIMLFGCTLAFPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVSRICFSPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCACHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVCADGWQEILSQLACKQMGLGEPSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQSCESRSKISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGRENAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDISETGYVRPVCLPNPEQWLEPDTYCYITGWGHMGNKMPFKLQEGEVRIISLEHCQSYFDMKTITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVYSNVSYFVEWIKRQIYIQTFLLN

Target ORF information:

RefSeq Version	NM_001278585.1
Organism	Homo sapiens(human)
Definition	Homo sapiens corin, serine peptidase (CORIN), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001278585.1

ORF Insert Sequence:

ATGAAACAGT CTCCTGCCCT CGCTCCGGAA GAGCGCTGCC GCAGAGCCGG GTCCCCAAAG 
CCGGTCTTGA GAGCTGATGA CAATAACATG GGCAATGGCT GCTCTCAGAA GCTGGCGACT 
GCTAACCTCC TCCGGTTCCT ATTGCTGGTC CTGATTCCAT GTATCTGTGC TCTCGTTCTC 
TTGCTGGTGA TCCTGCTTTC CTATGTTGGT GCCTGTATGA ACATCACCCA CAGCCAGTGT 
CAGATGCTGC CCTACCACGC CACGCTGACA CCTCTCCTCT CAGTTGTCAG AAACATGGAA 
ATGGAAAAGT TCCTCAAGTT TTTCACATAT CTCCATCGCC TCAGTTGCTA TCAACATATC 
ATGCTGTTTG GCTGTACCCT CGCCTTCCCT GAGTGCATCA TTGATGGCGA TGACAGTCAT 
GGACTCCTGC CCTGTAGGTC CTTCTGTGAG GCTGCAAAAG AAGGCTGTGA ATCAGTCCTG 
GGGATGGTGA ATTACTCCTG GCCGGATTTC CTCAGATGCT CCCAGTTTAG AAACCAAACT 
GAAAGCAGCA ATGTCAGCAG AATTTGCTTC TCACCTCAGC AGGAAAACGG AAAGCAATTG 
CTCTGTGGAA GGGGTGAGAA CTTTCTGTGT GCCAGTGGAA TCTGCATCCC CGGGAAACTG 
CAATGTAATG GCTACAACGA CTGTGACGAC TGGAGTGACG AGGCTCATTG CAACTGCAGC 
GAGAATCTGT TTCACTGTCA CACAGGCAAG TGCCTTAATT ACAGCCTTGT GTGTGATGGA 
TATGATGACT GTGGGGATTT GAGTGATGAG CAAAACTGTG CCTGTCACAG CCAGGGTCTG 
GTGGAATGCA GAAATGGACA ATGTATCCCC AGCACGTTTC AATGTGATGG TGACGAGGAC 
TGCAAGGATG GGAGTGATGA GGAGAACTGC AGCGTCATTC AGACTTCATG TCAAGAAGGA 
GACCAAAGAT GCCTCTACAA TCCCTGCCTT GATTCATGTG GTGGTAGCTC TCTCTGTGAC 
CCGAACAACA GTCTGAATAA CTGTAGTCAA TGTGAACCAA TTACATTGGA ACTCTGCATG 
AATTTGCCCT ACAACAGTAC AAGTTATCCA AATTATTTTG GCCACAGGAC TCAAAAGGAA 
GCATCCATCA GCTGGGAGTC TTCTCTTTTC CCTGCACTTG TTCAAACCAA CTGTTATAAA 
TACCTCATGT TCTTTTCTTG CACCATTTTG GTACCAAAAT GTGATGTGAA TACAGGCGAG 
CATATCCCTC CTTGCAGGGC ATTGTGTGAA CACTCTAAAG AACGCTGTGA GTCTGTTCTT 
GGGATTGTGG GCCTACAGTG GCCTGAAGAC ACAGATTGCA GTCAATTTCC AGAGGAAAAT 
TCAGACAATC AAACCTGCCT GATGCCTGAT GAATATGTGG AAGAATGCTC ACCTAGTCAT 
TTCAAGTGCC GCTCAGGACA GTGTGTTCTG GCTTCCAGAA GATGTGATGG CCAGGCCGAC 
TGTGACGATG ACAGTGATGA GGAAAACTGT GGTTGTAAAG AGAGAGATCT TTGGGAATGT 
CCATCCAATA AACAATGTTT GAAGCACACA GTGATCTGCG ATGGGTTCCC AGACTGCCCT 
GATTACATGG ACGAGAAAAA CTGCTCATTT TGCCAAGATG ATGAGCTGGA ATGTGCAAAC 
CATGCGTGTG TGTCACGTGA CCTGTGGTGT GATGGTGAAG CCGACTGCTC AGACAGTTCA 
GATGAATGGG ACTGTGTGAC CCTCTCTATA AATGTGAACT CCTCTTCCTT TCTGATGGTT 
CACAGAGCTG CCACAGAACA CCATGTGTGT GCAGATGGCT GGCAGGAGAT ATTGAGTCAG 
CTGGCCTGCA AGCAGATGGG TTTAGGAGAA CCATCTGTGA CCAAATTGAT ACAGGAACAG 
GAGAAAGAGC CGCGGTGGCT GACATTACAC TCCAACTGGG AGAGCCTCAA TGGGACCACT 
TTACATGAAC TTCTAGTAAA TGGGCAGTCT TGTGAGAGCA GAAGTAAAAT TTCTCTTCTG 
TGTACTAAAC AAGACTGTGG GCGCCGCCCT GCTGCCCGAA TGAACAAAAG GATCCTTGGA 
GGTCGGACGA GTCGCCCTGG AAGGTGGCCA TGGCAGTGTT CTCTGCAGAG TGAACCCAGT 
GGACATATCT GTGGCTGTGT CCTCATTGCC AAGAAGTGGG TTCTGACAGT TGCCCACTGC 
TTCGAGGGGA GAGAGAATGC TGCAGTTTGG AAAGTGGTGC TTGGCATCAA CAATCTAGAC 
CATCCATCAG TGTTCATGCA GACACGCTTT GTGAAGACCA TCATCCTGCA TCCCCGCTAC 
AGTCGAGCAG TGGTGGACTA TGACATCAGC ATCGTTGAGC TGAGTGAAGA CATCAGTGAG 
ACTGGCTACG TCCGGCCTGT CTGCTTGCCC AACCCGGAGC AGTGGCTAGA GCCTGACACG 
TACTGCTATA TCACAGGCTG GGGCCACATG GGCAATAAAA TGCCATTTAA GCTGCAAGAG 
GGAGAGGTCC GCATTATTTC TCTGGAACAT TGTCAGTCCT ACTTTGACAT GAAGACCATC 
ACCACTCGGA TGATATGTGC TGGCTATGAG TCTGGCACAG TTGATTCATG CATGGGTGAC 
AGCGGTGGGC CTCTTGTTTG TGAGAAGCCT GGAGGACGGT GGACATTATT TGGATTAACT 
TCATGGGGCT CCGTCTGCTT TTCCAAAGTC CTGGGGCCTG GCGTTTATAG TAATGTGTCA 
TATTTCGTCG AATGGATTAA AAGACAGATT TACATCCAGA CCTTTCTCCT AAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of Corin in Blood Pressure Regulation in Normotensive and Hypertensive Pregnancy.
Hypertension (Dallas, Tex. : 1979)73(2)432-439(2019 02)
Badrov MB,Park SY,Yoo JK,Hieda M,Okada Y,Jarvis SS,Stickford AS,Best SA,Nelson DB,Fu Q

Corin is a key regulator of endochondral ossification and bone development via modulation of vascular endothelial growth factor A expression.
Journal of tissue engineering and regenerative medicine12(12)2277-2286(2018 12)
Nordberg RC,Wang H,Wu Q,Loboa EG

Corin is highly expressed in atherosclerosis models.
Biochemical and biophysical research communications504(2)440-446(2018 10)
Jiang J,Zhou Q,Sun M,Zuo F,Jiang J

Association of rs2271037 and rs3749585 polymorphisms in CORIN with susceptibility to hypertension in a Chinese Han population: A case-control study.
Gene65179-85(2018 Apr)
Chen YL,Li TJ,Hao Y,Wu BG,Li H,Geng N,Sun ZQ,Zheng LQ,Sun YX

Aberrant pro-atrial natriuretic peptide/corin/natriuretic peptide receptor signaling is present in maternal vascular endothelium in preeclampsia.
Pregnancy hypertension111-6(2018 Jan)
Gu Y,Thompson D,Xu J,Lewis DF,Morgan JA,Cooper DB,McCathran CE,Wang Y

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CORIN cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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