AK6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	AK6
Entrez Gene ID	102157402
Full Name	adenylate kinase 6
Synonyms	AD-004,CGI-137,CINAP,CIP,hCINAP
General protein information	Preferred Names adenylate kinase 6 Names adenylate kinase isoenzyme 6 ATP-AMP transphosphorylase 6 adrenal gland protein AD-004 coilin interacting nuclear ATPase protein coilin interacting protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q13.2
Summary	This gene encodes a protein that belongs to the adenylate kinase family of enzymes. The protein has a nuclear localization and contains Walker A (P-loop) and Walker B motifs and a metal-coordinating residue. The protein may be involved in regulation of Cajal body formation. In human, AK6 and TAF9 (GeneID: 6880) are two distinct genes that share 5' exons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001015891.1	NP_001015891.1	adenylate kinase isoenzyme 6 isoform c
NM_001015891.2	NP_001015891.1	adenylate kinase isoenzyme 6 isoform c
NM_016283.4	NP_057367.1	adenylate kinase isoenzyme 6 isoform b
NM_016283.5	NP_057367.1	adenylate kinase isoenzyme 6 isoform b

Pathways from BioSystems

Homologies

Kluyveromyces lactis	KLLA0D12386g	XP_453614.1
Gallus gallus (chicken)	AK6	NP_001026504.1
Caenorhabditis elegans (roundworm)	E02H1.6	NP_496065.1
Mus musculus (house mouse)	Ak6	NP_081868.1
Macaca mulatta (Rhesus monkey)	LOC100423692	XP_002804469.1
Arabidopsis thaliana (thale cress)	AT5G60340	NP_200842.2
Schizosaccharomyces pombe (fission yeast)	SPCC830.11c	NP_588481.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000272	XP_310848.3
Homo sapiens (human)	AK6	NP_057367.1
Rattus norvegicus (Norway rat)	Ak6	NP_001012481.1
Saccharomyces cerevisiae (baker's yeast)	FAP7	NP_010115.1
Neurospora crassa	NCU10220	XP_001728530.1
Oryza sativa (rice)	Os07g0412400	NP_001059451.1
Pan troglodytes (chimpanzee)	AK6	XP_517726.2
Danio rerio (zebrafish)	zgc:86811	NP_001002118.1
Magnaporthe oryzae (rice blast fungus)	MGG_16212	XP_003709658.1
Drosophila melanogaster (fruit fly)	Ak6	NP_610797.1
Xenopus tropicalis (tropical clawed frog)	taf9	NP_001017167.1
Eremothecium gossypii	AGOS_ACL150W	NP_983254.1

Gene Ontology
Bibliography

Related articles in PubMed

hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy.
Xu R, Yu S, Zhu D, Huang X, Xu Y, Lao Y, Tian Y, Zhang J, Tang Z, Zhang Z, Yi J, Zhu HH, Zheng X
Nature communications10(1)3812(2019 08)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation.
Ji Y, Yang C, Tang Z, Yang Y, Tian Y, Yao H, Zhu X, Zhang Z, Ji J, Zheng X
Nature communications815308(2017 05)

The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth.
Bai D, Zhang J, Li T, Hang R, Liu Y, Tian Y, Huang D, Qu L, Cao X, Ji J, Zheng X
Nature communications712310(2016 08)

hCINAP is a novel regulator of ribosomal protein-HDM2-p53 pathway by controlling NEDDylation of ribosomal protein S14.
Zhang J, Bai D, Ma X, Guan J, Zheng X
Oncogene33(2)246-54(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following AK6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AK6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11536	NM_016283.5 Latest version!	Homo sapiens adenylate kinase 6 (AK6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu13191	NM_001015891.2 Latest version!	Homo sapiens adenylate kinase 6 (AK6), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu13191	NM_001015891.1	Homo sapiens adenylate kinase 6 (AK6), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu11536	NM_016283.4	Homo sapiens adenylate kinase 6 (AK6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AK6 ( NM_016283.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057367.1 Homo sapiens adenylate kinase 6 (AK6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu11536
Clone ID Related Accession (Same CDS sequence)	NM_016283.4 , NM_016283.5
Accession Version	NM_016283.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506700800000
Organism	Homo sapiens(human)
Product	adenylate kinase isoenzyme 6 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC145132.2, AF151895.1 and BC007426.2. On Apr 22, 2005 this sequence version replaced NM_016283.3. Transcript Variant: This variant (2) encodes the longer isoform (b). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.12034.1, SRR1163655.534967.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149178, SAMEA2154529 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTGCTTC CGAACATCCT GCTCACCGGT ACACCAGGGG TTGGAAAAAC CACACTAGGC 
AAAGAACTTG CGTCAAAATC AGGACTGAAA TACATTAATG TGGGTGATTT AGCTCGAGAA 
GAGCAATTGT ATGATGGCTA TGATGAAGAG TATGACTGTC CCATTTTAGA TGAAGACAGA 
GTAGTTGATG AGTTAGATAA CCAAATGAGA GAAGGTGGAG TTATTGTTGA TTACCATGGT 
TGTGATTTCT TCCCTGAACG CTGGTTTCAT ATAGTTTTTG TGCTGAGAAC AGATACCAAT 
GTATTGTACG AAAGACTTGA AACAAGGGGT TATAATGAGA AGAAACTAAC AGACAATATT 
CAGTGTGAGA TTTTTCAAGT TCTTTATGAA GAAGCCACAG CATCCTACAA GGAAGAAATC 
GTGCATCAGC TGCCCAGTAA TAAACCAGAA GAGCTAGAAA ATAATGTAGA TCAGATCTTG 
AAATGGATTG AGCAGTGGAT CAAAGATCAT AACTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057367.1
CDS	93..611
Translation	MLLPNILLTGTPGVGKTTLGKELASKSGLKYINVGDLAREEQLYDGYDEEYDCPILDEDRVVDELDNQMREGGVIVDYHGCDFFPERWFHIVFVLRTDTNVLYERLETRGYNEKKLTDNIQCEIFQVLYEEATASYKEEIVHQLPSNKPEELENNVDQILKWIEQWIKDHNS

Target ORF information:

RefSeq Version	NM_016283.4
Organism	Homo sapiens(human)
Definition	Homo sapiens adenylate kinase 6 (AK6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016283.4

ORF Insert Sequence:

ATGTTGCTTC CGAACATCCT GCTCACCGGT ACACCAGGGG TTGGAAAAAC CACACTAGGC 
AAAGAACTTG CGTCAAAATC AGGACTGAAA TACATTAATG TGGGTGATTT AGCTCGAGAA 
GAGCAATTGT ATGATGGCTA TGATGAAGAG TATGACTGTC CCATTTTAGA TGAAGACAGA 
GTAGTTGATG AGTTAGATAA CCAAATGAGA GAAGGTGGAG TTATTGTTGA TTACCATGGT 
TGTGATTTCT TCCCTGAACG CTGGTTTCAT ATAGTTTTTG TGCTGAGAAC AGATACCAAT 
GTATTGTACG AAAGACTTGA AACAAGGGGT TATAATGAGA AGAAACTAAC AGACAATATT 
CAGTGTGAGA TTTTTCAAGT TCTTTATGAA GAAGCCACAG CATCCTACAA GGAAGAAATC 
GTGCATCAGC TGCCCAGTAA TAAACCAGAA GAGCTAGAAA ATAATGTAGA TCAGATCTTG 
AAATGGATTG AGCAGTGGAT CAAAGATCAT AACTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AK6 ( NM_016283.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_057367.1 Homo sapiens adenylate kinase 6 (AK6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu11536
Clone ID Related Accession (Same CDS sequence)	NM_016283.4 , NM_016283.5
Accession Version	NM_016283.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577808000000
Organism	Homo sapiens(human)
Product	adenylate kinase isoenzyme 6 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF151895.1, BC007426.2 and AC145132.2. On Nov 22, 2018 this sequence version replaced NM_016283.4. Transcript Variant: This variant (2) encodes the longer isoform (b). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.49026.1, SRR1660807.103430.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149178, SAMEA2154529 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000380822.9/ ENSP00000370201.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTGCTTC CGAACATCCT GCTCACCGGT ACACCAGGGG TTGGAAAAAC CACACTAGGC 
AAAGAACTTG CGTCAAAATC AGGACTGAAA TACATTAATG TGGGTGATTT AGCTCGAGAA 
GAGCAATTGT ATGATGGCTA TGATGAAGAG TATGACTGTC CCATTTTAGA TGAAGACAGA 
GTAGTTGATG AGTTAGATAA CCAAATGAGA GAAGGTGGAG TTATTGTTGA TTACCATGGT 
TGTGATTTCT TCCCTGAACG CTGGTTTCAT ATAGTTTTTG TGCTGAGAAC AGATACCAAT 
GTATTGTACG AAAGACTTGA AACAAGGGGT TATAATGAGA AGAAACTAAC AGACAATATT 
CAGTGTGAGA TTTTTCAAGT TCTTTATGAA GAAGCCACAG CATCCTACAA GGAAGAAATC 
GTGCATCAGC TGCCCAGTAA TAAACCAGAA GAGCTAGAAA ATAATGTAGA TCAGATCTTG 
AAATGGATTG AGCAGTGGAT CAAAGATCAT AACTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057367.1
CDS	31..549
Translation	MLLPNILLTGTPGVGKTTLGKELASKSGLKYINVGDLAREEQLYDGYDEEYDCPILDEDRVVDELDNQMREGGVIVDYHGCDFFPERWFHIVFVLRTDTNVLYERLETRGYNEKKLTDNIQCEIFQVLYEEATASYKEEIVHQLPSNKPEELENNVDQILKWIEQWIKDHNS

Target ORF information:

RefSeq Version	NM_016283.5
Organism	Homo sapiens(human)
Definition	Homo sapiens adenylate kinase 6 (AK6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016283.5

ORF Insert Sequence:

ATGTTGCTTC CGAACATCCT GCTCACCGGT ACACCAGGGG TTGGAAAAAC CACACTAGGC 
AAAGAACTTG CGTCAAAATC AGGACTGAAA TACATTAATG TGGGTGATTT AGCTCGAGAA 
GAGCAATTGT ATGATGGCTA TGATGAAGAG TATGACTGTC CCATTTTAGA TGAAGACAGA 
GTAGTTGATG AGTTAGATAA CCAAATGAGA GAAGGTGGAG TTATTGTTGA TTACCATGGT 
TGTGATTTCT TCCCTGAACG CTGGTTTCAT ATAGTTTTTG TGCTGAGAAC AGATACCAAT 
GTATTGTACG AAAGACTTGA AACAAGGGGT TATAATGAGA AGAAACTAAC AGACAATATT 
CAGTGTGAGA TTTTTCAAGT TCTTTATGAA GAAGCCACAG CATCCTACAA GGAAGAAATC 
GTGCATCAGC TGCCCAGTAA TAAACCAGAA GAGCTAGAAA ATAATGTAGA TCAGATCTTG 
AAATGGATTG AGCAGTGGAT CAAAGATCAT AACTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AK6 ( NM_001015891.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001015891.1 Homo sapiens adenylate kinase 6 (AK6), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu13191
Clone ID Related Accession (Same CDS sequence)	NM_001015891.1 , NM_001015891.2
Accession Version	NM_001015891.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 510bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1551110400000
Organism	Homo sapiens(human)
Product	adenylate kinase isoenzyme 6 isoform c
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX117839.1, AC145132.2 and BC007349.2. Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 2. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform b. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.105120.1, SRR1163655.110578.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149178, SAMEA2154529 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGTCATC GAAAGCCAGG TACACCAGGG GTTGGAAAAA CCACACTAGG CAAAGAACTT 
GCGTCAAAAT CAGGACTGAA ATACATTAAT GTGGGTGATT TAGCTCGAGA AGAGCAATTG 
TATGATGGCT ATGATGAAGA GTATGACTGT CCCATTTTAG ATGAAGACAG AGTAGTTGAT 
GAGTTAGATA ACCAAATGAG AGAAGGTGGA GTTATTGTTG ATTACCATGG TTGTGATTTC 
TTCCCTGAAC GCTGGTTTCA TATAGTTTTT GTGCTGAGAA CAGATACCAA TGTATTGTAC 
GAAAGACTTG AAACAAGGGG TTATAATGAG AAGAAACTAA CAGACAATAT TCAGTGTGAG 
ATTTTTCAAG TTCTTTATGA AGAAGCCACA GCATCCTACA AGGAAGAAAT CGTGCATCAG 
CTGCCCAGTA ATAAACCAGA AGAGCTAGAA AATAATGTAG ATCAGATCTT GAAATGGATT 
GAGCAGTGGA TCAAAGATCA TAACTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001015891.1
CDS	339..848
Translation	MCHRKPGTPGVGKTTLGKELASKSGLKYINVGDLAREEQLYDGYDEEYDCPILDEDRVVDELDNQMREGGVIVDYHGCDFFPERWFHIVFVLRTDTNVLYERLETRGYNEKKLTDNIQCEIFQVLYEEATASYKEEIVHQLPSNKPEELENNVDQILKWIEQWIKDHNS

Target ORF information:

RefSeq Version	NM_001015891.1
Organism	Homo sapiens(human)
Definition	Homo sapiens adenylate kinase 6 (AK6), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001015891.1

ORF Insert Sequence:

ATGTGTCATC GAAAGCCAGG TACACCAGGG GTTGGAAAAA CCACACTAGG CAAAGAACTT 
GCGTCAAAAT CAGGACTGAA ATACATTAAT GTGGGTGATT TAGCTCGAGA AGAGCAATTG 
TATGATGGCT ATGATGAAGA GTATGACTGT CCCATTTTAG ATGAAGACAG AGTAGTTGAT 
GAGTTAGATA ACCAAATGAG AGAAGGTGGA GTTATTGTTG ATTACCATGG TTGTGATTTC 
TTCCCTGAAC GCTGGTTTCA TATAGTTTTT GTGCTGAGAA CAGATACCAA TGTATTGTAC 
GAAAGACTTG AAACAAGGGG TTATAATGAG AAGAAACTAA CAGACAATAT TCAGTGTGAG 
ATTTTTCAAG TTCTTTATGA AGAAGCCACA GCATCCTACA AGGAAGAAAT CGTGCATCAG 
CTGCCCAGTA ATAAACCAGA AGAGCTAGAA AATAATGTAG ATCAGATCTT GAAATGGATT 
GAGCAGTGGA TCAAAGATCA TAACTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AK6 ( NM_001015891.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001015891.1 Homo sapiens adenylate kinase 6 (AK6), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu13191
Clone ID Related Accession (Same CDS sequence)	NM_001015891.1 , NM_001015891.2
Accession Version	NM_001015891.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 510bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577980800000
Organism	Homo sapiens(human)
Product	adenylate kinase isoenzyme 6 isoform c
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX117839.1, AC145132.2 and BC007349.2. On May 31, 2019 this sequence version replaced NM_001015891.1. Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 2. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform b. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189661.144537.1, SRR1163655.110578.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149178, SAMEA2154529 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGTCATC GAAAGCCAGG TACACCAGGG GTTGGAAAAA CCACACTAGG CAAAGAACTT 
GCGTCAAAAT CAGGACTGAA ATACATTAAT GTGGGTGATT TAGCTCGAGA AGAGCAATTG 
TATGATGGCT ATGATGAAGA GTATGACTGT CCCATTTTAG ATGAAGACAG AGTAGTTGAT 
GAGTTAGATA ACCAAATGAG AGAAGGTGGA GTTATTGTTG ATTACCATGG TTGTGATTTC 
TTCCCTGAAC GCTGGTTTCA TATAGTTTTT GTGCTGAGAA CAGATACCAA TGTATTGTAC 
GAAAGACTTG AAACAAGGGG TTATAATGAG AAGAAACTAA CAGACAATAT TCAGTGTGAG 
ATTTTTCAAG TTCTTTATGA AGAAGCCACA GCATCCTACA AGGAAGAAAT CGTGCATCAG 
CTGCCCAGTA ATAAACCAGA AGAGCTAGAA AATAATGTAG ATCAGATCTT GAAATGGATT 
GAGCAGTGGA TCAAAGATCA TAACTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001015891.1
CDS	150..659
Translation	MCHRKPGTPGVGKTTLGKELASKSGLKYINVGDLAREEQLYDGYDEEYDCPILDEDRVVDELDNQMREGGVIVDYHGCDFFPERWFHIVFVLRTDTNVLYERLETRGYNEKKLTDNIQCEIFQVLYEEATASYKEEIVHQLPSNKPEELENNVDQILKWIEQWIKDHNS

Target ORF information:

RefSeq Version	NM_001015891.2
Organism	Homo sapiens(human)
Definition	Homo sapiens adenylate kinase 6 (AK6), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001015891.2

ORF Insert Sequence:

ATGTGTCATC GAAAGCCAGG TACACCAGGG GTTGGAAAAA CCACACTAGG CAAAGAACTT 
GCGTCAAAAT CAGGACTGAA ATACATTAAT GTGGGTGATT TAGCTCGAGA AGAGCAATTG 
TATGATGGCT ATGATGAAGA GTATGACTGT CCCATTTTAG ATGAAGACAG AGTAGTTGAT 
GAGTTAGATA ACCAAATGAG AGAAGGTGGA GTTATTGTTG ATTACCATGG TTGTGATTTC 
TTCCCTGAAC GCTGGTTTCA TATAGTTTTT GTGCTGAGAA CAGATACCAA TGTATTGTAC 
GAAAGACTTG AAACAAGGGG TTATAATGAG AAGAAACTAA CAGACAATAT TCAGTGTGAG 
ATTTTTCAAG TTCTTTATGA AGAAGCCACA GCATCCTACA AGGAAGAAAT CGTGCATCAG 
CTGCCCAGTA ATAAACCAGA AGAGCTAGAA AATAATGTAG ATCAGATCTT GAAATGGATT 
GAGCAGTGGA TCAAAGATCA TAACTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy.
Nature communications10(1)3812(2019 08)
Xu R,Yu S,Zhu D,Huang X,Xu Y,Lao Y,Tian Y,Zhang J,Tang Z,Zhang Z,Yi J,Zhu HH,Zheng X

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation.
Nature communications815308(2017 05)
Ji Y,Yang C,Tang Z,Yang Y,Tian Y,Yao H,Zhu X,Zhang Z,Ji J,Zheng X

The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth.
Nature communications712310(2016 08)
Bai D,Zhang J,Li T,Hang R,Liu Y,Tian Y,Huang D,Qu L,Cao X,Ji J,Zheng X

hCINAP is a novel regulator of ribosomal protein-HDM2-p53 pathway by controlling NEDDylation of ribosomal protein S14.
Oncogene33(2)246-54(2014 Jan)
Zhang J,Bai D,Ma X,Guan J,Zheng X

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AK6 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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