WASF2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	WASF2
Entrez Gene ID	10163
Full Name	WAS protein family member 2
Synonyms	IMD2,SCAR2,WASF4,WAVE2,dJ393P12.2
General protein information	Preferred Names WAS protein family member 2 Names wiskott-Aldrich syndrome protein family member 2 WASP family Verprolin-homologous protein 2 WASP family protein member 2 WASP family protein member 4 protein WAVE-2 putative Wiskott-Aldrich syndrome protein family member 4 suppressor of cyclic-AMP receptor (WASP-family) verprolin homology domain-containing protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.11
Summary	This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011].
Disorder MIM:	605875

mRNA and Protein(s)

mRNA	Protein	Name
NM_006990.4	NP_008921.1	wiskott-Aldrich syndrome protein family member 2 isoform 1
NM_001201404.3	NP_001188333.1	wiskott-Aldrich syndrome protein family member 2 isoform 2
NM_006990.5	NP_008921.1	wiskott-Aldrich syndrome protein family member 2 isoform 1
NM_001201404.2	NP_001188333.1	wiskott-Aldrich syndrome protein family member 2 isoform 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	WASF2	NP_001074980.1
Mus musculus (house mouse)	Wasf2	NP_700472.1
Gallus gallus (chicken)	WASF2	XP_424015.3
Danio rerio (zebrafish)	wasf2	NP_957375.1
Pan troglodytes (chimpanzee)	WASF2	XP_513245.3
Homo sapiens (human)	WASF2	NP_008921.1
Macaca mulatta (Rhesus monkey)	LOC716082	XP_001111312.2
Canis lupus familiaris (dog)	WASF2	XP_544469.1

Gene Ontology
Bibliography

Related articles in PubMed

WAVE2 is associated with poor prognosis in pancreatic cancers and promotes cell motility and invasiveness via binding to ACTN4.
Taniuchi K, Furihata M, Naganuma S, Saibara T
Cancer medicine7(11)5733-5751(2018 11)

Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson's disease.
Kim KS, Marcogliese PC, Yang J, Callaghan SM, Resende V, Abdel-Messih E, Marras C, Visanji NP, Huang J, Schlossmacher MG, Trinkle-Mulcahy L, Slack RS, Lang AE, , Park DS
Proceedings of the National Academy of Sciences of the United States of America115(22)E5164-E5173(2018 05)

SH3BP1-induced Rac-Wave2 pathway activation regulates cervical cancer cell migration, invasion, and chemoresistance to cisplatin.
Wang J, Feng Y, Chen X, Du Z, Jiang S, Ma S, Zou W
Journal of cellular biochemistry119(2)1733-1745(2018 02)

Clinicopathological significance of the microRNA-146a/WASP-family verprolin-homologous protein-2 axis in gastric cancer.
Yao Q, Tu C, Lu D, Zou Y, Liu H, Zhang S
Cancer science108(7)1285-1292(2017 Jul)

Inhibition of the Rac1-WAVE2-Arp2/3 signaling pathway promotes radiosensitivity via downregulation of cofilin-1 in U251 human glioma cells.
Zhou T, Wang CH, Yan H, Zhang R, Zhao JB, Qian CF, Xiao H, Liu HY
Molecular medicine reports13(5)4414-20(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following WASF2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the WASF2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15226	NM_001201404.3 Latest version!	Homo sapiens WASP family member 2 (WASF2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu15215	NM_006990.5 Latest version!	Homo sapiens WASP family member 2 (WASF2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$258.30 $369.00
View Old Accession Versions >>
OHu15215	NM_006990.4	Homo sapiens WAS protein family member 2 (WASF2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$258.30 $369.00
OHu15226	NM_001201404.2	Homo sapiens WASP family member 2 (WASF2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

WASF2 ( NM_001201404.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001188333.1 Homo sapiens WASP family member 2 (WASF2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu15226
Clone ID Related Accession (Same CDS sequence)	NM_001201404.3 , NM_001201404.2
Accession Version	NM_001201404.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 846bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1573315200000
Organism	Homo sapiens(human)
Product	wiskott-Aldrich syndrome protein family member 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY001891.1, AK303011.1, FO393419.1 and AA736923.1. On May 31, 2019 this sequence version replaced NM_001201404.2. Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK303011.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGTTAG TAACGAGGAA CATCGAGCCA AGGCACCTGT GCCGTCAGAC GTTGCCTAGC 
GTTAGAAGCG AGCTGGAATG CGTGACCAAC ATCACCCTGG CAAATGTCAT CCGACAGCTG 
GGCAGCCTGA GTAAATATGC AGAGGACATT TTTGGAGAGC TCTTTACTCA GGCAAATACC 
TTTGCCTCTC GGGTAAGCTC CCTTGCTGAG AGGGTCGACC GACTACAGGT TAAAGTCACT 
CAGCTGGATC CCAAGGAAGA AGAAGTGTCA CTGCAAGGAA TCAACACCCG AAAAGCCTTC 
AGAAGTTCCA CCATTCAAGA CCAGAAGCTT TTTGACAGAA ACTCTCTCCC AGTGCCTGTC 
TTAGAAACAT ACAATACCTG TGATACTCCT CCCCCTCTCA ACAATCTTAC CCCTTACAGG 
GACGATGGAA AAGAGGCACT CAAATTCTAC ACAGACCCTT CATACTTCTT TGATCTTTGG 
AAGGAGAAGA TGCTGCAGGA CACCAAGGAT ATCATGAAAG AGAAGAGAAA GCATAGGAAA 
GAAAAGAAAG ATAATCCAAA TCGAGGGAAT GTAAACCCAC GTAAAATCAA GACACGTAAG 
GAAGAGTGGG AGAAAATGAA GATGGGGCAA GAATTTGTGG AGTCCAAAGA AAAGCTGGGG 
ACTTCTGGGT ATCCACCCAC TTTGGTGTAC CAGAATGGCA GCATTGGCTG TGTTGAAAAC 
GTGGATGCAA GTAGCTATCC GCCACCACCA CAGTCAGACT CTGCTTCTTC ACCTTCTCCT 
TCCTTCTCCG AGGACAACTT GCCTCCTCCA CCAGCAGAAT TCAGGTTTTC AGCTGCGCAG 
GGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001188333.1
CDS	226..1071
Translation	MPLVTRNIEPRHLCRQTLPSVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQANTFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVPVLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHRKEKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIGCVENVDASSYPPPPQSDSASSPSPSFSEDNLPPPPAEFRFSAAQG

Target ORF information:

RefSeq Version	NM_001201404.3
Organism	Homo sapiens(human)
Definition	Homo sapiens WASP family member 2 (WASF2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001201404.3

ORF Insert Sequence:

ATGCCGTTAG TAACGAGGAA CATCGAGCCA AGGCACCTGT GCCGTCAGAC GTTGCCTAGC 
GTTAGAAGCG AGCTGGAATG CGTGACCAAC ATCACCCTGG CAAATGTCAT CCGACAGCTG 
GGCAGCCTGA GTAAATATGC AGAGGACATT TTTGGAGAGC TCTTTACTCA GGCAAATACC 
TTTGCCTCTC GGGTAAGCTC CCTTGCTGAG AGGGTCGACC GACTACAGGT TAAAGTCACT 
CAGCTGGATC CCAAGGAAGA AGAAGTGTCA CTGCAAGGAA TCAACACCCG AAAAGCCTTC 
AGAAGTTCCA CCATTCAAGA CCAGAAGCTT TTTGACAGAA ACTCTCTCCC AGTGCCTGTC 
TTAGAAACAT ACAATACCTG TGATACTCCT CCCCCTCTCA ACAATCTTAC CCCTTACAGG 
GACGATGGAA AAGAGGCACT CAAATTCTAC ACAGACCCTT CATACTTCTT TGATCTTTGG 
AAGGAGAAGA TGCTGCAGGA CACCAAGGAT ATCATGAAAG AGAAGAGAAA GCATAGGAAA 
GAAAAGAAAG ATAATCCAAA TCGAGGGAAT GTAAACCCAC GTAAAATCAA GACACGTAAG 
GAAGAGTGGG AGAAAATGAA GATGGGGCAA GAATTTGTGG AGTCCAAAGA AAAGCTGGGG 
ACTTCTGGGT ATCCACCCAC TTTGGTGTAC CAGAATGGCA GCATTGGCTG TGTTGAAAAC 
GTGGATGCAA GTAGCTATCC GCCACCACCA CAGTCAGACT CTGCTTCTTC ACCTTCTCCT 
TCCTTCTCCG AGGACAACTT GCCTCCTCCA CCAGCAGAAT TCAGGTTTTC AGCTGCGCAG 
GGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

WASF2 ( NM_001201404.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001188333.1 Homo sapiens WASP family member 2 (WASF2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu15226
Clone ID Related Accession (Same CDS sequence)	NM_001201404.3 , NM_001201404.2
Accession Version	NM_001201404.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 846bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550332800000
Organism	Homo sapiens(human)
Product	wiskott-Aldrich syndrome protein family member 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC300388.1, HY001891.1, AK303011.1, FO393419.1 and AA736923.1. On Jan 13, 2015 this sequence version replaced NM_001201404.1. Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK303011.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGTTAG TAACGAGGAA CATCGAGCCA AGGCACCTGT GCCGTCAGAC GTTGCCTAGC 
GTTAGAAGCG AGCTGGAATG CGTGACCAAC ATCACCCTGG CAAATGTCAT CCGACAGCTG 
GGCAGCCTGA GTAAATATGC AGAGGACATT TTTGGAGAGC TCTTTACTCA GGCAAATACC 
TTTGCCTCTC GGGTAAGCTC CCTTGCTGAG AGGGTCGACC GACTACAGGT TAAAGTCACT 
CAGCTGGATC CCAAGGAAGA AGAAGTGTCA CTGCAAGGAA TCAACACCCG AAAAGCCTTC 
AGAAGTTCCA CCATTCAAGA CCAGAAGCTT TTTGACAGAA ACTCTCTCCC AGTGCCTGTC 
TTAGAAACAT ACAATACCTG TGATACTCCT CCCCCTCTCA ACAATCTTAC CCCTTACAGG 
GACGATGGAA AAGAGGCACT CAAATTCTAC ACAGACCCTT CATACTTCTT TGATCTTTGG 
AAGGAGAAGA TGCTGCAGGA CACCAAGGAT ATCATGAAAG AGAAGAGAAA GCATAGGAAA 
GAAAAGAAAG ATAATCCAAA TCGAGGGAAT GTAAACCCAC GTAAAATCAA GACACGTAAG 
GAAGAGTGGG AGAAAATGAA GATGGGGCAA GAATTTGTGG AGTCCAAAGA AAAGCTGGGG 
ACTTCTGGGT ATCCACCCAC TTTGGTGTAC CAGAATGGCA GCATTGGCTG TGTTGAAAAC 
GTGGATGCAA GTAGCTATCC GCCACCACCA CAGTCAGACT CTGCTTCTTC ACCTTCTCCT 
TCCTTCTCCG AGGACAACTT GCCTCCTCCA CCAGCAGAAT TCAGGTTTTC AGCTGCGCAG 
GGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001188333.1
CDS	246..1091
Translation	MPLVTRNIEPRHLCRQTLPSVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQANTFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVPVLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHRKEKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIGCVENVDASSYPPPPQSDSASSPSPSFSEDNLPPPPAEFRFSAAQG

Target ORF information:

RefSeq Version	NM_001201404.2
Organism	Homo sapiens(human)
Definition	Homo sapiens WASP family member 2 (WASF2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001201404.2

ORF Insert Sequence:

ATGCCGTTAG TAACGAGGAA CATCGAGCCA AGGCACCTGT GCCGTCAGAC GTTGCCTAGC 
GTTAGAAGCG AGCTGGAATG CGTGACCAAC ATCACCCTGG CAAATGTCAT CCGACAGCTG 
GGCAGCCTGA GTAAATATGC AGAGGACATT TTTGGAGAGC TCTTTACTCA GGCAAATACC 
TTTGCCTCTC GGGTAAGCTC CCTTGCTGAG AGGGTCGACC GACTACAGGT TAAAGTCACT 
CAGCTGGATC CCAAGGAAGA AGAAGTGTCA CTGCAAGGAA TCAACACCCG AAAAGCCTTC 
AGAAGTTCCA CCATTCAAGA CCAGAAGCTT TTTGACAGAA ACTCTCTCCC AGTGCCTGTC 
TTAGAAACAT ACAATACCTG TGATACTCCT CCCCCTCTCA ACAATCTTAC CCCTTACAGG 
GACGATGGAA AAGAGGCACT CAAATTCTAC ACAGACCCTT CATACTTCTT TGATCTTTGG 
AAGGAGAAGA TGCTGCAGGA CACCAAGGAT ATCATGAAAG AGAAGAGAAA GCATAGGAAA 
GAAAAGAAAG ATAATCCAAA TCGAGGGAAT GTAAACCCAC GTAAAATCAA GACACGTAAG 
GAAGAGTGGG AGAAAATGAA GATGGGGCAA GAATTTGTGG AGTCCAAAGA AAAGCTGGGG 
ACTTCTGGGT ATCCACCCAC TTTGGTGTAC CAGAATGGCA GCATTGGCTG TGTTGAAAAC 
GTGGATGCAA GTAGCTATCC GCCACCACCA CAGTCAGACT CTGCTTCTTC ACCTTCTCCT 
TCCTTCTCCG AGGACAACTT GCCTCCTCCA CCAGCAGAAT TCAGGTTTTC AGCTGCGCAG 
GGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

WASF2 ( NM_006990.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_008921.1 Homo sapiens WAS protein family member 2 (WASF2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu15215
Clone ID Related Accession (Same CDS sequence)	NM_006990.4 , NM_006990.5
Accession Version	NM_006990.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1497bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1505577600000
Organism	Homo sapiens(human)
Product	wiskott-Aldrich syndrome protein family member 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC300388.1, BC040943.1, FO393419.1 and AA736923.1. On Jan 13, 2015 this sequence version replaced NM_006990.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC040943.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGTTAG TAACGAGGAA CATCGAGCCA AGGCACCTGT GCCGTCAGAC GTTGCCTAGC 
GTTAGAAGCG AGCTGGAATG CGTGACCAAC ATCACCCTGG CAAATGTCAT CCGACAGCTG 
GGCAGCCTGA GTAAATATGC AGAGGACATT TTTGGAGAGC TCTTTACTCA GGCAAATACC 
TTTGCCTCTC GGGTAAGCTC CCTTGCTGAG AGGGTCGACC GACTACAGGT TAAAGTCACT 
CAGCTGGATC CCAAGGAAGA AGAAGTGTCA CTGCAAGGAA TCAACACCCG AAAAGCCTTC 
AGAAGTTCCA CCATTCAAGA CCAGAAGCTT TTTGACAGAA ACTCTCTCCC AGTGCCTGTC 
TTAGAAACAT ACAATACCTG TGATACTCCT CCCCCTCTCA ACAATCTTAC CCCTTACAGG 
GACGATGGAA AAGAGGCACT CAAATTCTAC ACAGACCCTT CATACTTCTT TGATCTTTGG 
AAGGAGAAGA TGCTGCAGGA CACCAAGGAT ATCATGAAAG AGAAGAGAAA GCATAGGAAA 
GAAAAGAAAG ATAATCCAAA TCGAGGGAAT GTAAACCCAC GTAAAATCAA GACACGTAAG 
GAAGAGTGGG AGAAAATGAA GATGGGGCAA GAATTTGTGG AGTCCAAAGA AAAGCTGGGG 
ACTTCTGGGT ATCCACCCAC TTTGGTGTAC CAGAATGGCA GCATTGGCTG TGTTGAAAAC 
GTGGATGCAA GTAGCTATCC GCCACCACCA CAGTCAGACT CTGCTTCTTC ACCTTCTCCT 
TCCTTCTCCG AGGACAACTT GCCTCCTCCA CCAGCAGAAT TCAGTTACCC AGTGGACAAC 
CAAAGAGGAT CTGGTTTGGC TGGACCCAAA AGATCCAGTG TGGTCAGCCC AAGCCATCCA 
CCACCAGCTC CTCCTCTAGG CTCTCCACCA GGCCCTAAAC CCGGGTTTGC TCCACCACCT 
GCCCCTCCGC CACCTCCGCC TCCAATGATA GGCATCCCAC CTCCACCACC GCCTGTAGGA 
TTTGGGTCTC CAGGGACGCC TCCACCACCC TCACCCCCAT CTTTCCCACC TCACCCTGAT 
TTTGCTGCCC CTCCACCTCC TCCTCCACCA CCAGCAGCTG ACTACCCAAC TCTGCCACCA 
CCTCCCTTGT CCCAGCCAAC AGGAGGAGCA CCTCCTCCTC CCCCTCCTCC TCCTCCTCCG 
GGGCCCCCTC CTCCCCCTTT CACTGGTGCA GATGGCCAGC CTGCTATACC ACCACCGCTT 
TCTGATACCA CCAAGCCCAA GTCCTCCTTG CCTGCCGTGA GCGATGCCCG TAGCGACCTG 
CTTTCAGCCA TCCGTCAAGG TTTTCAGCTG CGCAGGGTTG AGGAGCAGCG GGAACAAGAG 
AAGCGGGATG TTGTGGGCAA TGACGTGGCC ACCATCTTGT CTCGTCGCAT TGCTGTTGAG 
TACAGTGACT CAGAAGATGA CTCCTCTGAA TTTGATGAGG ACGACTGGTC CGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008921.1
CDS	246..1742
Translation	MPLVTRNIEPRHLCRQTLPSVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQANTFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVPVLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHRKEKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIGCVENVDASSYPPPPQSDSASSPSPSFSEDNLPPPPAEFSYPVDNQRGSGLAGPKRSSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPPGPPPPPFTGADGQPAIPPPLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQEKRDVVGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD

Target ORF information:

RefSeq Version	NM_006990.4
Organism	Homo sapiens(human)
Definition	Homo sapiens WAS protein family member 2 (WASF2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006990.4

ORF Insert Sequence:

ATGCCGTTAG TAACGAGGAA CATCGAGCCA AGGCACCTGT GCCGTCAGAC GTTGCCTAGC 
GTTAGAAGCG AGCTGGAATG CGTGACCAAC ATCACCCTGG CAAATGTCAT CCGACAGCTG 
GGCAGCCTGA GTAAATATGC AGAGGACATT TTTGGAGAGC TCTTTACTCA GGCAAATACC 
TTTGCCTCTC GGGTAAGCTC CCTTGCTGAG AGGGTCGACC GACTACAGGT TAAAGTCACT 
CAGCTGGATC CCAAGGAAGA AGAAGTGTCA CTGCAAGGAA TCAACACCCG AAAAGCCTTC 
AGAAGTTCCA CCATTCAAGA CCAGAAGCTT TTTGACAGAA ACTCTCTCCC AGTGCCTGTC 
TTAGAAACAT ACAATACCTG TGATACTCCT CCCCCTCTCA ACAATCTTAC CCCTTACAGG 
GACGATGGAA AAGAGGCACT CAAATTCTAC ACAGACCCTT CATACTTCTT TGATCTTTGG 
AAGGAGAAGA TGCTGCAGGA CACCAAGGAT ATCATGAAAG AGAAGAGAAA GCATAGGAAA 
GAAAAGAAAG ATAATCCAAA TCGAGGGAAT GTAAACCCAC GTAAAATCAA GACACGTAAG 
GAAGAGTGGG AGAAAATGAA GATGGGGCAA GAATTTGTGG AGTCCAAAGA AAAGCTGGGG 
ACTTCTGGGT ATCCACCCAC TTTGGTGTAC CAGAATGGCA GCATTGGCTG TGTTGAAAAC 
GTGGATGCAA GTAGCTATCC GCCACCACCA CAGTCAGACT CTGCTTCTTC ACCTTCTCCT 
TCCTTCTCCG AGGACAACTT GCCTCCTCCA CCAGCAGAAT TCAGTTACCC AGTGGACAAC 
CAAAGAGGAT CTGGTTTGGC TGGACCCAAA AGATCCAGTG TGGTCAGCCC AAGCCATCCA 
CCACCAGCTC CTCCTCTAGG CTCTCCACCA GGCCCTAAAC CCGGGTTTGC TCCACCACCT 
GCCCCTCCGC CACCTCCGCC TCCAATGATA GGCATCCCAC CTCCACCACC GCCTGTAGGA 
TTTGGGTCTC CAGGGACGCC TCCACCACCC TCACCCCCAT CTTTCCCACC TCACCCTGAT 
TTTGCTGCCC CTCCACCTCC TCCTCCACCA CCAGCAGCTG ACTACCCAAC TCTGCCACCA 
CCTCCCTTGT CCCAGCCAAC AGGAGGAGCA CCTCCTCCTC CCCCTCCTCC TCCTCCTCCG 
GGGCCCCCTC CTCCCCCTTT CACTGGTGCA GATGGCCAGC CTGCTATACC ACCACCGCTT 
TCTGATACCA CCAAGCCCAA GTCCTCCTTG CCTGCCGTGA GCGATGCCCG TAGCGACCTG 
CTTTCAGCCA TCCGTCAAGG TTTTCAGCTG CGCAGGGTTG AGGAGCAGCG GGAACAAGAG 
AAGCGGGATG TTGTGGGCAA TGACGTGGCC ACCATCTTGT CTCGTCGCAT TGCTGTTGAG 
TACAGTGACT CAGAAGATGA CTCCTCTGAA TTTGATGAGG ACGACTGGTC CGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

WASF2 ( NM_006990.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_008921.1 Homo sapiens WASP family member 2 (WASF2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu15215
Clone ID Related Accession (Same CDS sequence)	NM_006990.4 , NM_006990.5
Accession Version	NM_006990.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1497bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1573315200000
Organism	Homo sapiens(human)
Product	wiskott-Aldrich syndrome protein family member 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC300388.1, BC040943.1, FO393419.1 and AA736923.1. On Nov 22, 2018 this sequence version replaced NM_006990.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC040943.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000618852.5/ ENSP00000483313.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCGTTAG TAACGAGGAA CATCGAGCCA AGGCACCTGT GCCGTCAGAC GTTGCCTAGC 
GTTAGAAGCG AGCTGGAATG CGTGACCAAC ATCACCCTGG CAAATGTCAT CCGACAGCTG 
GGCAGCCTGA GTAAATATGC AGAGGACATT TTTGGAGAGC TCTTTACTCA GGCAAATACC 
TTTGCCTCTC GGGTAAGCTC CCTTGCTGAG AGGGTCGACC GACTACAGGT TAAAGTCACT 
CAGCTGGATC CCAAGGAAGA AGAAGTGTCA CTGCAAGGAA TCAACACCCG AAAAGCCTTC 
AGAAGTTCCA CCATTCAAGA CCAGAAGCTT TTTGACAGAA ACTCTCTCCC AGTGCCTGTC 
TTAGAAACAT ACAATACCTG TGATACTCCT CCCCCTCTCA ACAATCTTAC CCCTTACAGG 
GACGATGGAA AAGAGGCACT CAAATTCTAC ACAGACCCTT CATACTTCTT TGATCTTTGG 
AAGGAGAAGA TGCTGCAGGA CACCAAGGAT ATCATGAAAG AGAAGAGAAA GCATAGGAAA 
GAAAAGAAAG ATAATCCAAA TCGAGGGAAT GTAAACCCAC GTAAAATCAA GACACGTAAG 
GAAGAGTGGG AGAAAATGAA GATGGGGCAA GAATTTGTGG AGTCCAAAGA AAAGCTGGGG 
ACTTCTGGGT ATCCACCCAC TTTGGTGTAC CAGAATGGCA GCATTGGCTG TGTTGAAAAC 
GTGGATGCAA GTAGCTATCC GCCACCACCA CAGTCAGACT CTGCTTCTTC ACCTTCTCCT 
TCCTTCTCCG AGGACAACTT GCCTCCTCCA CCAGCAGAAT TCAGTTACCC AGTGGACAAC 
CAAAGAGGAT CTGGTTTGGC TGGACCCAAA AGATCCAGTG TGGTCAGCCC AAGCCATCCA 
CCACCAGCTC CTCCTCTAGG CTCTCCACCA GGCCCTAAAC CCGGGTTTGC TCCACCACCT 
GCCCCTCCGC CACCTCCGCC TCCAATGATA GGCATCCCAC CTCCACCACC GCCTGTAGGA 
TTTGGGTCTC CAGGGACGCC TCCACCACCC TCACCCCCAT CTTTCCCACC TCACCCTGAT 
TTTGCTGCCC CTCCACCTCC TCCTCCACCA CCAGCAGCTG ACTACCCAAC TCTGCCACCA 
CCTCCCTTGT CCCAGCCAAC AGGAGGAGCA CCTCCTCCTC CCCCTCCTCC TCCTCCTCCG 
GGGCCCCCTC CTCCCCCTTT CACTGGTGCA GATGGCCAGC CTGCTATACC ACCACCGCTT 
TCTGATACCA CCAAGCCCAA GTCCTCCTTG CCTGCCGTGA GCGATGCCCG TAGCGACCTG 
CTTTCAGCCA TCCGTCAAGG TTTTCAGCTG CGCAGGGTTG AGGAGCAGCG GGAACAAGAG 
AAGCGGGATG TTGTGGGCAA TGACGTGGCC ACCATCTTGT CTCGTCGCAT TGCTGTTGAG 
TACAGTGACT CAGAAGATGA CTCCTCTGAA TTTGATGAGG ACGACTGGTC CGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008921.1
CDS	226..1722
Translation	MPLVTRNIEPRHLCRQTLPSVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQANTFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVPVLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHRKEKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIGCVENVDASSYPPPPQSDSASSPSPSFSEDNLPPPPAEFSYPVDNQRGSGLAGPKRSSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPPGPPPPPFTGADGQPAIPPPLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQEKRDVVGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD

Target ORF information:

RefSeq Version	NM_006990.5
Organism	Homo sapiens(human)
Definition	Homo sapiens WASP family member 2 (WASF2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006990.5

ORF Insert Sequence:

ATGCCGTTAG TAACGAGGAA CATCGAGCCA AGGCACCTGT GCCGTCAGAC GTTGCCTAGC 
GTTAGAAGCG AGCTGGAATG CGTGACCAAC ATCACCCTGG CAAATGTCAT CCGACAGCTG 
GGCAGCCTGA GTAAATATGC AGAGGACATT TTTGGAGAGC TCTTTACTCA GGCAAATACC 
TTTGCCTCTC GGGTAAGCTC CCTTGCTGAG AGGGTCGACC GACTACAGGT TAAAGTCACT 
CAGCTGGATC CCAAGGAAGA AGAAGTGTCA CTGCAAGGAA TCAACACCCG AAAAGCCTTC 
AGAAGTTCCA CCATTCAAGA CCAGAAGCTT TTTGACAGAA ACTCTCTCCC AGTGCCTGTC 
TTAGAAACAT ACAATACCTG TGATACTCCT CCCCCTCTCA ACAATCTTAC CCCTTACAGG 
GACGATGGAA AAGAGGCACT CAAATTCTAC ACAGACCCTT CATACTTCTT TGATCTTTGG 
AAGGAGAAGA TGCTGCAGGA CACCAAGGAT ATCATGAAAG AGAAGAGAAA GCATAGGAAA 
GAAAAGAAAG ATAATCCAAA TCGAGGGAAT GTAAACCCAC GTAAAATCAA GACACGTAAG 
GAAGAGTGGG AGAAAATGAA GATGGGGCAA GAATTTGTGG AGTCCAAAGA AAAGCTGGGG 
ACTTCTGGGT ATCCACCCAC TTTGGTGTAC CAGAATGGCA GCATTGGCTG TGTTGAAAAC 
GTGGATGCAA GTAGCTATCC GCCACCACCA CAGTCAGACT CTGCTTCTTC ACCTTCTCCT 
TCCTTCTCCG AGGACAACTT GCCTCCTCCA CCAGCAGAAT TCAGTTACCC AGTGGACAAC 
CAAAGAGGAT CTGGTTTGGC TGGACCCAAA AGATCCAGTG TGGTCAGCCC AAGCCATCCA 
CCACCAGCTC CTCCTCTAGG CTCTCCACCA GGCCCTAAAC CCGGGTTTGC TCCACCACCT 
GCCCCTCCGC CACCTCCGCC TCCAATGATA GGCATCCCAC CTCCACCACC GCCTGTAGGA 
TTTGGGTCTC CAGGGACGCC TCCACCACCC TCACCCCCAT CTTTCCCACC TCACCCTGAT 
TTTGCTGCCC CTCCACCTCC TCCTCCACCA CCAGCAGCTG ACTACCCAAC TCTGCCACCA 
CCTCCCTTGT CCCAGCCAAC AGGAGGAGCA CCTCCTCCTC CCCCTCCTCC TCCTCCTCCG 
GGGCCCCCTC CTCCCCCTTT CACTGGTGCA GATGGCCAGC CTGCTATACC ACCACCGCTT 
TCTGATACCA CCAAGCCCAA GTCCTCCTTG CCTGCCGTGA GCGATGCCCG TAGCGACCTG 
CTTTCAGCCA TCCGTCAAGG TTTTCAGCTG CGCAGGGTTG AGGAGCAGCG GGAACAAGAG 
AAGCGGGATG TTGTGGGCAA TGACGTGGCC ACCATCTTGT CTCGTCGCAT TGCTGTTGAG 
TACAGTGACT CAGAAGATGA CTCCTCTGAA TTTGATGAGG ACGACTGGTC CGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

WAVE2 is associated with poor prognosis in pancreatic cancers and promotes cell motility and invasiveness via binding to ACTN4.
Cancer medicine7(11)5733-5751(2018 11)
Taniuchi K,Furihata M,Naganuma S,Saibara T

Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America115(22)E5164-E5173(2018 05)
Kim KS,Marcogliese PC,Yang J,Callaghan SM,Resende V,Abdel-Messih E,Marras C,Visanji NP,Huang J,Schlossmacher MG,Trinkle-Mulcahy L,Slack RS,Lang AE,,Park DS

SH3BP1-induced Rac-Wave2 pathway activation regulates cervical cancer cell migration, invasion, and chemoresistance to cisplatin.
Journal of cellular biochemistry119(2)1733-1745(2018 02)
Wang J,Feng Y,Chen X,Du Z,Jiang S,Ma S,Zou W

Clinicopathological significance of the microRNA-146a/WASP-family verprolin-homologous protein-2 axis in gastric cancer.
Cancer science108(7)1285-1292(2017 Jul)
Yao Q,Tu C,Lu D,Zou Y,Liu H,Zhang S

Inhibition of the Rac1-WAVE2-Arp2/3 signaling pathway promotes radiosensitivity via downregulation of cofilin-1 in U251 human glioma cells.
Molecular medicine reports13(5)4414-20(2016 May)
Zhou T,Wang CH,Yan H,Zhang R,Zhao JB,Qian CF,Xiao H,Liu HY

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WASF2 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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