XRCC6 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	XRCC6
Entrez Gene ID	395767
Full Name	X-ray repair complementing defective repair in Chinese hamster cells 6
Synonyms	KU70
General protein information	Preferred Names X-ray repair complementing defective repair in Chinese hamster cells 6 Names X-ray repair cross-complementing protein 5 5'-dRP/AP lyase Ku70 5'-deoxyribose-5-phosphate lyase Ku70 ATP-dependent DNA helicase 2 subunit 1 ATP-dependent DNA helicase II 70 kDa subunit DNA repair protein XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa) ku autoantigen protein p70 homolog
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_204927.2	NP_990258.2	X-ray repair cross-complementing protein 5 precursor

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	XRCC6	XP_001105684.1
Gallus gallus (chicken)	XRCC6	NP_990258.1
Danio rerio (zebrafish)	LOC100536337	XP_003199637.1
Neurospora crassa	NCU08290	XP_962503.2
Canis lupus familiaris (dog)	XRCC6	XP_005625882.1
Mus musculus (house mouse)	Xrcc6	NP_034377.2
Xenopus tropicalis (tropical clawed frog)	xrcc6	NP_001005700.1
Danio rerio (zebrafish)	xrcc6	NP_956198.1
Arabidopsis thaliana (thale cress)	KU70	NP_564012.1
Oryza sativa (rice)	Os07g0184900	NP_001059061.1
Kluyveromyces lactis	KLLA0C06226g	XP_452475.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002690	XP_312232.5
Schizosaccharomyces pombe (fission yeast)	pku70	NP_588445.1
Bos taurus (cattle)	XRCC6	NP_001179175.1
Rattus norvegicus (Norway rat)	Xrcc6	NP_620780.2
Magnaporthe oryzae (rice blast fungus)	MGG_01512	XP_003714485.1
Homo sapiens (human)	XRCC6	NP_001460.1
Pan troglodytes (chimpanzee)	XRCC6	XP_521301.3
Drosophila melanogaster (fruit fly)	Irbp	NP_536773.1
Caenorhabditis elegans (roundworm)	cku-70	NP_499438.2
Saccharomyces cerevisiae (baker's yeast)	YKU70	NP_014011.1

Gene Ontology
Bibliography

Related articles in PubMed

Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway.
Pace P, Mosedale G, Hodskinson MR, Rosado IV, Sivasubramaniam M, Patel KJ
Science (New York, N.Y.)329(5988)219-23(2010 Jul)

KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation.
Abe T, Ishiai M, Hosono Y, Yoshimura A, Tada S, Adachi N, Koyama H, Takata M, Takeda S, Enomoto T, Seki M
Cellular signalling20(11)1978-85(2008 Nov)

Ku70 prevents genome instability resulting from heterozygosity of the telomerase RNA component in a vertebrate tumour line.
Faure V, Wenner T, Cooley C, Bourke E, Farr CJ, Takeda S, Morrison CG
DNA repair7(5)713-24(2008 May)

A comprehensive collection of chicken cDNAs.
Boardman PE, Sanz-Ezquerro J, Overton IM, Burt DW, Bosch E, Fong WT, Tickle C, Brown WR, Wilson SA, Hubbard SJ
Current biology : CB12(22)1965-9(2002 Nov)

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells.
Takata M, Sasaki MS, Sonoda E, Morrison C, Hashimoto M, Utsumi H, Yamaguchi-Iwai Y, Shinohara A, Takeda S
The EMBO journal17(18)5497-508(1998 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following XRCC6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the XRCC6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa28379	NM_204927.2 Latest version!	Gallus gallus X-ray repair complementing defective repair in Chinese hamster cells 6 (XRCC6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

XRCC6 ( NM_204927.2 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_990258.2 Gallus gallus X-ray repair complementing defective repair in Chinese hamster cells 6 (XRCC6), mRNA.

Price & Availability↑

CloneID	OGa28379
Clone ID Related Accession (Same CDS sequence)	NM_204927.2
Accession Version	NM_204927.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1899bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1564675200000
Organism	Gallus gallus(chicken)
Product	X-ray repair cross-complementing protein 5 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB016529.1, AJ451455.1, BU433464.1, BU427388.1, BU470412.1, BU343450.1 and AADN05000523.1. On Mar 19, 2015 this sequence version replaced NM_204927.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA2201357, SAMEA2201358 [ECO:0000350] ##Evidence-Data-END##

ATGGAGATGT GGGTGTTGGG GGAGGTTGGA ATGGCGGTTC TCTCGGCAGC GGCCATGGCC 
GACTGGGTGT CCTATTATCG TGGCGACGGG CCGGACGAGG AGGAGGACGG CGAGCAGCAG 
GAGGAGGAGG GGCCGGAGGC TGTGGCGGAC TACAGGTTCT CGGGGCGGGA CAGCTTGATT 
TTCTTGGTCG ACGCCTCCAA GGCCATGTTC GAGCCCTACG AGGATGAGGA GGCGGCCACT 
CCCTTTGACA TGACCATGCA GTGCATCCGG AATGTGTACA CCAGCAAAAT TATTAGTAGT 
GATAAGGATC TGTTAAGCGT TGTGTTCTAC GGCACGGAGA ACAACAAGAA CTCCGCAGAC 
TTCAAGCATG TCTATGTCCT TCAGGAGCTG GACAATCCAG GTGCAAAGCG TATTCTGGAG 
CTGGACCAGT ACAGGGGAGA TGAAGGACGA GTACTGTTCC GTGAGACCTT TGGCCACAAT 
GCTGACTATT CACTGGGTGA AGCACTCTGG GCCTGCTCTA ATCTCTTCAG CGATGTCCGA 
GTTAGACTAA GCCACAAAAG GATCATGCTT TTCACCAACG AGGATAACCC TCATGCCAAT 
GATAGTGCTA AGGCCAAGCT GGCCAGGACC AGAGCTGGTG ATCTGAGAGA CACAGGTATA 
ATCCTGGACT TGATGCACTT GAAGAAGCCG GGAGGGTTCG ATATCTCTTT GTTCTACAGG 
GACATCATCA ACGTAGCAGA GGATGAGGAC CTTGGGATCC AGCCTGATGA GTCAGGGAAA 
CTAGAGCATC TCATGAAGAA AGTACGAGCA AAGGAGACAA GGAAACGGGC TTTAAGCAGG 
TTAAATCTGT ATTTGAACAA AGATCTGTCT TTCTCTGTTG GCGTTTACAA CCTGATTCAA 
AAAGCTTACA AGCCATATCC AGTGAAACTT TATCGGGAAA CTAATGAACC TGTTAAAACA 
AAAACGAGGG TGTTTAATGG AAAAACAGGC AGTTTGCTTC TGCCTAGCGA TACAAAAAGG 
GCTCAGACAT ATGGAAACCG CCAGATTGCG ATGGAGAAGG AGGAGACAGA AGAAGTGAAA 
CGGTTTGATT CTCCGGGCTT GTTTCTCATT GGCTTCAAAC CACTTTCAAT GCTAAAACAG 
CACCACCATA TCAGGCCCTC CCAGTTCATG TATCCTGAAG AGTCCCTAGT AACTGGCAGT 
ACAACTCTGT TTAATGCCTT ATTGATGAAG TGCTTGGAGA AAGAGGTGAT GGCACTGTGC 
AGATACATCG CCCGCCGGAA CACTCCCCCT CGCATTGTGG CCCTGATTCC TCAGGAGGAA 
GAGGTGGATG AACAGAAAGT GCAGATAGCT CCTCCAGGTT TCCACATCAT TTTCCTACCA 
TATGCAGACG ATAAACGGAA CGTTGATTTT ACAGAAAAGG TACCAGCCAA TCGAGAACAG 
GTGGACAAAA TGAAGGAGAT CATTCAAAAA CTCCGCTTCA AATACAGGAC TGACAGCTTT 
GAGAACCCAG TTTTGCAGCA GCACTTCAGG AATCTGGAGG CTTTGGCGCT GGATATGCTG 
GAACCAGAAC AAGCTGAGGA TCTTACAATG CCAAAGACTG AAGAGATGAG CCGCAGGCTG 
GGCAACCTGG TGGAGGAGTT CAAGCAGCTG GTTTATCCTC CTGACTACAG CCCTGAAGGG 
AAGGCTGCAA AGCGAAAACA AGCTGGTGAT GCTCAAGCAG AAAAGAGGCC CAAGATAGAA 
ATCTCAGAAG ATTCACTGAG GAGTTATGTG CAGAATGGCA CTCTGGGCAA GCTCACTGTC 
TCTGCTCTGA AGGATACGTG CAGGCATTAT GGGCTGAGGA GCGGGGGGAA GAAGCAGGAG 
CTCATCGATG CACTGACTGA ATACTTCAGT GGGCGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_990258.2
CDS	1..1899
Translation	MEMWVLGEVGMAVLSAAAMADWVSYYRGDGPDEEEDGEQQEEEGPEAVADYRFSGRDSLIFLVDASKAMFEPYEDEEAATPFDMTMQCIRNVYTSKIISSDKDLLSVVFYGTENNKNSADFKHVYVLQELDNPGAKRILELDQYRGDEGRVLFRETFGHNADYSLGEALWACSNLFSDVRVRLSHKRIMLFTNEDNPHANDSAKAKLARTRAGDLRDTGIILDLMHLKKPGGFDISLFYRDIINVAEDEDLGIQPDESGKLEHLMKKVRAKETRKRALSRLNLYLNKDLSFSVGVYNLIQKAYKPYPVKLYRETNEPVKTKTRVFNGKTGSLLLPSDTKRAQTYGNRQIAMEKEETEEVKRFDSPGLFLIGFKPLSMLKQHHHIRPSQFMYPEESLVTGSTTLFNALLMKCLEKEVMALCRYIARRNTPPRIVALIPQEEEVDEQKVQIAPPGFHIIFLPYADDKRNVDFTEKVPANREQVDKMKEIIQKLRFKYRTDSFENPVLQQHFRNLEALALDMLEPEQAEDLTMPKTEEMSRRLGNLVEEFKQLVYPPDYSPEGKAAKRKQAGDAQAEKRPKIEISEDSLRSYVQNGTLGKLTVSALKDTCRHYGLRSGGKKQELIDALTEYFSGR

Target ORF information:

RefSeq Version	NM_204927.2
Organism	Gallus gallus(chicken)
Definition	Gallus gallus X-ray repair complementing defective repair in Chinese hamster cells 6 (XRCC6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_204927.2

ORF Insert Sequence:

ATGGAGATGT GGGTGTTGGG GGAGGTTGGA ATGGCGGTTC TCTCGGCAGC GGCCATGGCC 
GACTGGGTGT CCTATTATCG TGGCGACGGG CCGGACGAGG AGGAGGACGG CGAGCAGCAG 
GAGGAGGAGG GGCCGGAGGC TGTGGCGGAC TACAGGTTCT CGGGGCGGGA CAGCTTGATT 
TTCTTGGTCG ACGCCTCCAA GGCCATGTTC GAGCCCTACG AGGATGAGGA GGCGGCCACT 
CCCTTTGACA TGACCATGCA GTGCATCCGG AATGTGTACA CCAGCAAAAT TATTAGTAGT 
GATAAGGATC TGTTAAGCGT TGTGTTCTAC GGCACGGAGA ACAACAAGAA CTCCGCAGAC 
TTCAAGCATG TCTATGTCCT TCAGGAGCTG GACAATCCAG GTGCAAAGCG TATTCTGGAG 
CTGGACCAGT ACAGGGGAGA TGAAGGACGA GTACTGTTCC GTGAGACCTT TGGCCACAAT 
GCTGACTATT CACTGGGTGA AGCACTCTGG GCCTGCTCTA ATCTCTTCAG CGATGTCCGA 
GTTAGACTAA GCCACAAAAG GATCATGCTT TTCACCAACG AGGATAACCC TCATGCCAAT 
GATAGTGCTA AGGCCAAGCT GGCCAGGACC AGAGCTGGTG ATCTGAGAGA CACAGGTATA 
ATCCTGGACT TGATGCACTT GAAGAAGCCG GGAGGGTTCG ATATCTCTTT GTTCTACAGG 
GACATCATCA ACGTAGCAGA GGATGAGGAC CTTGGGATCC AGCCTGATGA GTCAGGGAAA 
CTAGAGCATC TCATGAAGAA AGTACGAGCA AAGGAGACAA GGAAACGGGC TTTAAGCAGG 
TTAAATCTGT ATTTGAACAA AGATCTGTCT TTCTCTGTTG GCGTTTACAA CCTGATTCAA 
AAAGCTTACA AGCCATATCC AGTGAAACTT TATCGGGAAA CTAATGAACC TGTTAAAACA 
AAAACGAGGG TGTTTAATGG AAAAACAGGC AGTTTGCTTC TGCCTAGCGA TACAAAAAGG 
GCTCAGACAT ATGGAAACCG CCAGATTGCG ATGGAGAAGG AGGAGACAGA AGAAGTGAAA 
CGGTTTGATT CTCCGGGCTT GTTTCTCATT GGCTTCAAAC CACTTTCAAT GCTAAAACAG 
CACCACCATA TCAGGCCCTC CCAGTTCATG TATCCTGAAG AGTCCCTAGT AACTGGCAGT 
ACAACTCTGT TTAATGCCTT ATTGATGAAG TGCTTGGAGA AAGAGGTGAT GGCACTGTGC 
AGATACATCG CCCGCCGGAA CACTCCCCCT CGCATTGTGG CCCTGATTCC TCAGGAGGAA 
GAGGTGGATG AACAGAAAGT GCAGATAGCT CCTCCAGGTT TCCACATCAT TTTCCTACCA 
TATGCAGACG ATAAACGGAA CGTTGATTTT ACAGAAAAGG TACCAGCCAA TCGAGAACAG 
GTGGACAAAA TGAAGGAGAT CATTCAAAAA CTCCGCTTCA AATACAGGAC TGACAGCTTT 
GAGAACCCAG TTTTGCAGCA GCACTTCAGG AATCTGGAGG CTTTGGCGCT GGATATGCTG 
GAACCAGAAC AAGCTGAGGA TCTTACAATG CCAAAGACTG AAGAGATGAG CCGCAGGCTG 
GGCAACCTGG TGGAGGAGTT CAAGCAGCTG GTTTATCCTC CTGACTACAG CCCTGAAGGG 
AAGGCTGCAA AGCGAAAACA AGCTGGTGAT GCTCAAGCAG AAAAGAGGCC CAAGATAGAA 
ATCTCAGAAG ATTCACTGAG GAGTTATGTG CAGAATGGCA CTCTGGGCAA GCTCACTGTC 
TCTGCTCTGA AGGATACGTG CAGGCATTAT GGGCTGAGGA GCGGGGGGAA GAAGCAGGAG 
CTCATCGATG CACTGACTGA ATACTTCAGT GGGCGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway.
Science (New York, N.Y.)329(5988)219-23(2010 Jul)
Pace P,Mosedale G,Hodskinson MR,Rosado IV,Sivasubramaniam M,Patel KJ

KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation.
Cellular signalling20(11)1978-85(2008 Nov)
Abe T,Ishiai M,Hosono Y,Yoshimura A,Tada S,Adachi N,Koyama H,Takata M,Takeda S,Enomoto T,Seki M

Ku70 prevents genome instability resulting from heterozygosity of the telomerase RNA component in a vertebrate tumour line.
DNA repair7(5)713-24(2008 May)
Faure V,Wenner T,Cooley C,Bourke E,Farr CJ,Takeda S,Morrison CG

A comprehensive collection of chicken cDNAs.
Current biology : CB12(22)1965-9(2002 Nov)
Boardman PE,Sanz-Ezquerro J,Overton IM,Burt DW,Bosch E,Fong WT,Tickle C,Brown WR,Wilson SA,Hubbard SJ

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells.
The EMBO journal17(18)5497-508(1998 Sep)
Takata M,Sasaki MS,Sonoda E,Morrison C,Hashimoto M,Utsumi H,Yamaguchi-Iwai Y,Shinohara A,Takeda S

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XRCC6 cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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