APP cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	APP
Entrez Gene ID	374198
Full Name	amyloid beta (A4) precursor protein
General protein information	Preferred Names amyloid beta (A4) precursor protein Names amyloid beta A4 protein amyloid protein
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_204308.1	NP_989639.1	amyloid-beta A4 protein precursor
XM_015299094.1	XP_015154580.1	amyloid beta A4 protein isoform X1
XM_015299094.2	XP_015154580.1	amyloid-beta A4 protein isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	APP	NP_000475.1
Bos taurus (cattle)	APP	NP_001070264.1
Pan troglodytes (chimpanzee)	APP	NP_001013036.1
Rattus norvegicus (Norway rat)	App	NP_062161.1
Caenorhabditis elegans (roundworm)	apl-1	NP_508870.3
Danio rerio (zebrafish)	appb	NP_690842.1
Canis lupus familiaris (dog)	APP	NP_001006601.1
Xenopus tropicalis (tropical clawed frog)	app	NP_001005698.1
Mus musculus (house mouse)	App	NP_001185752.1
Gallus gallus (chicken)	APP	NP_989639.1
Macaca mulatta (Rhesus monkey)	APP	XP_002803216.1

Gene Ontology
Bibliography

Related articles in PubMed

Inhibition of choline acetyltransferase as a mechanism for cholinergic dysfunction induced by amyloid-β peptide oligomers.
Nunes-Tavares N, Santos LE, Stutz B, Brito-Moreira J, Klein WL, Ferreira ST, de Mello FG
The Journal of biological chemistry287(23)19377-85(2012 Jun)

Comparison of pharmacological modulation of APP metabolism in primary chicken telencephalic neurons and in a human neuroglioma cell line.
Czvitkovich S, Duller S, Mathiesen E, Lorenzoni K, Imbimbo BP, Hutter-Paier B, Windisch M, Wronski R
Journal of molecular neuroscience : MN43(3)257-67(2011 Mar)

Hen lysozyme amyloid fibrils induce aggregation of erythrocytes and lipid vesicles.
Chaudhary N, Nagaraj R
Molecular and cellular biochemistry328(1-2)209-15(2009 Aug)

The chick embryo appears as a natural model for research in beta-amyloid precursor protein processing.
Carrodeguas JA, Rodolosse A, Garza MV, Sanz-Clemente A, Pérez-Pé R, Lacosta AM, Domínguez L, Monleón I, Sánchez-Díaz R, Sorribas V, Sarasa M
Neuroscience134(4)1285-300(2005)

Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease.
Maloney B, Ge YW, Greig N, Lahiri DK
FASEB journal : official publication of the Federation of American Societies for Experimental Biology18(11)1288-90(2004 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following APP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the APP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OGa26020	NM_204308.1 Latest version!	Gallus gallus amyloid beta (A4) precursor protein (APP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OGa30230	XM_015299094.2 Latest version!	Gallus gallus amyloid beta (A4) precursor protein (APP), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
View Old Accession Versions >>
OGa30230	XM_015299094.1	Gallus gallus amyloid beta (A4) precursor protein (APP), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

APP ( NM_204308.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_989639.1 Gallus gallus amyloid beta (A4) precursor protein (APP), mRNA.

Price & Availability↑

CloneID	OGa26020
Clone ID Related Accession (Same CDS sequence)	NM_204308.1
Accession Version	NM_204308.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2256bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1526745600000
Organism	Gallus gallus(chicken)
Product	amyloid-beta A4 protein precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF289219.1. ##Evidence-Data-START## Transcript exon combination :: AF289219.1 [ECO:0000332] ##Evidence-Data-END##

ATGCTGCCCC ACTTAGCCCT TTTGCTGCTG GCCGCCGGCG CCGCCCGGGC CCTTGAGGTG 
CCTGCTGATG GAAATGCTGG ATTGTTGGCA GAGCCTCAAA TTGCCATGTT CTGTGGCAAA 
CTCAATATGC ACATGAATGT TCAGAACGGA AAATGGGAAT CTGACCCCTC TGGGACCAAG 
ACCTGTATCG ACACTAAAGA AGGGATTCTG CAGTATTGCC AGGAAGTTTA CCCTGAATTG 
CAAATTACCA ATGTTGTCGA AGCCAACCAG CCGGTTACAA TCCAGAATTG GTGCAAGAGA 
GGATGGAAGC AGTGCAATGG TCACCCACAT ATTGTGGTTC CCTACAGGTG TTTGGTGGGT 
GAGTTTGTGA GTGATGCCCT TCTGGTACCG GACAAGTGCA AGTTGCTTCA CCAGGAAAGG 
ATGGATGTGT GTGAAACTCA CCTGCACTGG CATACTGTTG CTAAAGAGTC CTGCAGCGAG 
AAGAGTATGA ATCTGCATGA CTATGGCATG CTGCTGCCCT GTGGAATTGA CAAGTTTCGT 
GGTGTGGAAT TTGTTTGCTG CCCATTAGCA GAGGAAAGCG ACAATCTTGA CTCAGCTGAT 
GCTGAAGATG ATGATTCAGA TGTCTGGTGG GGAGGCGCAG ATGCAGACTA TGCAGATGGA 
AGCGATGATA AGGTGGTAGA AGAACAACCA GAGGAAGACG AGGAGCTAAC TGTTGTGGAG 
GATGAAGATG CTGATGATGA TGACGATGAT GATGGTGATG AAATTGAAGA GACAGAGGAG 
GAGTATGAGG AAGCAACAGA AAGAACTACC AGTATCGCAA CCACTACCAC CACAACTACA 
GAGTCCGTGG AAGAAGTTGT CAGAGAGGTG TGCTCTGAAC AAGCTGAGAC CGGTCCCTGC 
CGTGCAATGA TCTCCCGCTG GTACTTTGAC GTGGCCGAAG GAAAGTGCGC GCCCTTCTTT 
TACGGCGGCT GCGGTGGCAA CCGGAACAAC TTTGACTCGG AGGAGTACTG CATGGCAGTC 
TGCGGCAGCG TCCTCCCTAC CACAGCTGCT AGCACTCCTG ATGCTGTTGA CAAATACTTG 
GAGACACCTG GGGATGAAAA TGAACATGCT CATTTCCAGA AAGCCAAGGA GAGGCTTGAA 
GCTAAGCATC GTGAAAGGAT GTCTCAGGTC ATGAGGGAAT GGGAGGAGGC AGAACGCCAA 
GCAAAGAATT TGCCAAAGGC TGACAAGAAA GCTGTTATCC AGCATTTCCA GGAGAAAGTG 
GAATCACTGG AACAAGAAGC AGCAAATGAA AGGCAACAGC TTGTGGAGAC TCACATGGCA 
CGGGTGGAAG CCATGCTGAA TGACCGTCGC CGCATTGCTC TGGAGAACTA CATTACAGCA 
CTGCAGACTG TCCCACCCAG ACCTCGTCAC GTATTCAACA TGCTGAAGAA GTATGTGCGT 
GCTGAGCAGA AAGACAGACA GCATACTCTC AAACACTTCG AACATGTCCG GATGGTAGAC 
CCAAAGAAAG CTGCCCAGAT TAGATCTCAG GTTATGACAC ATCTACGTGT GATATACGAA 
CGCATGAACC AGTCTCTCTC CTTCCTCTAC AATGTGCCTG CTGTAGCTGA GGAGATCCAG 
GATGAAGTCG ATGAGTTGCT TCAGAAAGAG CAAAACTACT CTGACGATGT TCTGGCCAAT 
ATGATCAGCG AACCTAGAAT CAGCTATGGA AATGATGCTC TCATGCCTTC ATTGACGGAA 
ACTAAGACCA CAGTTGAACT TCTTCCAGTG GATGGAGAGT TCAGTCTCGA TGACCTTCAG 
CCATGGCATC CCTTTGGTGT TGATTCTGTT CCAGCCAATA CTGAAAATGA AGTTGAGCCT 
GTTGATGCCC GCCCAGCTGC AGACAGAGGA CTCACCACAC GACCAGGTTC TGGCTTGACC 
AATGTTAAAA CAGAAGAGGT ATCTGAAGTA AAGATGGATG CGGAGTTCCG ACATGACTCA 
GGATATGAAG TGCATCATCA AAAGCTGGTG TTCTTTGCTG AAGATGTGGG TTCAAATAAA 
GGTGCCATCA TTGGACTAAT GGTGGGAGGT GTTGTCATAG CGACAGTGAT TGTCATTACT 
CTGGTGATGC TGAAGAAGAA GCAGTACACA TCTATTCATC ATGGGGTTGT GGAGGTGGAT 
GCTGCAGTGA CACCAGAGGA GCGCCACCTC TCCAAGATGC AGCAGAACGG CTACGAGAAC 
CCCACCTACA AGTTCTTCGA ACAGATGCAG AATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_989639.1
CDS	109..2364
Translation	MLPHLALLLLAAGAARALEVPADGNAGLLAEPQIAMFCGKLNMHMNVQNGKWESDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGWKQCNGHPHIVVPYRCLVGEFVSDALLVPDKCKLLHQERMDVCETHLHWHTVAKESCSEKSMNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNLDSADAEDDDSDVWWGGADADYADGSDDKVVEEQPEEDEELTVVEDEDADDDDDDDGDEIEETEEEYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVAEGKCAPFFYGGCGGNRNNFDSEEYCMAVCGSVLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRIALENYITALQTVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSFLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVDGEFSLDDLQPWHPFGVDSVPANTENEVEPVDARPAADRGLTTRPGSGLTNVKTEEVSEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN

Target ORF information:

RefSeq Version	NM_204308.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus amyloid beta (A4) precursor protein (APP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_204308.1

ORF Insert Sequence:

ATGCTGCCCC ACTTAGCCCT TTTGCTGCTG GCCGCCGGCG CCGCCCGGGC CCTTGAGGTG 
CCTGCTGATG GAAATGCTGG ATTGTTGGCA GAGCCTCAAA TTGCCATGTT CTGTGGCAAA 
CTCAATATGC ACATGAATGT TCAGAACGGA AAATGGGAAT CTGACCCCTC TGGGACCAAG 
ACCTGTATCG ACACTAAAGA AGGGATTCTG CAGTATTGCC AGGAAGTTTA CCCTGAATTG 
CAAATTACCA ATGTTGTCGA AGCCAACCAG CCGGTTACAA TCCAGAATTG GTGCAAGAGA 
GGATGGAAGC AGTGCAATGG TCACCCACAT ATTGTGGTTC CCTACAGGTG TTTGGTGGGT 
GAGTTTGTGA GTGATGCCCT TCTGGTACCG GACAAGTGCA AGTTGCTTCA CCAGGAAAGG 
ATGGATGTGT GTGAAACTCA CCTGCACTGG CATACTGTTG CTAAAGAGTC CTGCAGCGAG 
AAGAGTATGA ATCTGCATGA CTATGGCATG CTGCTGCCCT GTGGAATTGA CAAGTTTCGT 
GGTGTGGAAT TTGTTTGCTG CCCATTAGCA GAGGAAAGCG ACAATCTTGA CTCAGCTGAT 
GCTGAAGATG ATGATTCAGA TGTCTGGTGG GGAGGCGCAG ATGCAGACTA TGCAGATGGA 
AGCGATGATA AGGTGGTAGA AGAACAACCA GAGGAAGACG AGGAGCTAAC TGTTGTGGAG 
GATGAAGATG CTGATGATGA TGACGATGAT GATGGTGATG AAATTGAAGA GACAGAGGAG 
GAGTATGAGG AAGCAACAGA AAGAACTACC AGTATCGCAA CCACTACCAC CACAACTACA 
GAGTCCGTGG AAGAAGTTGT CAGAGAGGTG TGCTCTGAAC AAGCTGAGAC CGGTCCCTGC 
CGTGCAATGA TCTCCCGCTG GTACTTTGAC GTGGCCGAAG GAAAGTGCGC GCCCTTCTTT 
TACGGCGGCT GCGGTGGCAA CCGGAACAAC TTTGACTCGG AGGAGTACTG CATGGCAGTC 
TGCGGCAGCG TCCTCCCTAC CACAGCTGCT AGCACTCCTG ATGCTGTTGA CAAATACTTG 
GAGACACCTG GGGATGAAAA TGAACATGCT CATTTCCAGA AAGCCAAGGA GAGGCTTGAA 
GCTAAGCATC GTGAAAGGAT GTCTCAGGTC ATGAGGGAAT GGGAGGAGGC AGAACGCCAA 
GCAAAGAATT TGCCAAAGGC TGACAAGAAA GCTGTTATCC AGCATTTCCA GGAGAAAGTG 
GAATCACTGG AACAAGAAGC AGCAAATGAA AGGCAACAGC TTGTGGAGAC TCACATGGCA 
CGGGTGGAAG CCATGCTGAA TGACCGTCGC CGCATTGCTC TGGAGAACTA CATTACAGCA 
CTGCAGACTG TCCCACCCAG ACCTCGTCAC GTATTCAACA TGCTGAAGAA GTATGTGCGT 
GCTGAGCAGA AAGACAGACA GCATACTCTC AAACACTTCG AACATGTCCG GATGGTAGAC 
CCAAAGAAAG CTGCCCAGAT TAGATCTCAG GTTATGACAC ATCTACGTGT GATATACGAA 
CGCATGAACC AGTCTCTCTC CTTCCTCTAC AATGTGCCTG CTGTAGCTGA GGAGATCCAG 
GATGAAGTCG ATGAGTTGCT TCAGAAAGAG CAAAACTACT CTGACGATGT TCTGGCCAAT 
ATGATCAGCG AACCTAGAAT CAGCTATGGA AATGATGCTC TCATGCCTTC ATTGACGGAA 
ACTAAGACCA CAGTTGAACT TCTTCCAGTG GATGGAGAGT TCAGTCTCGA TGACCTTCAG 
CCATGGCATC CCTTTGGTGT TGATTCTGTT CCAGCCAATA CTGAAAATGA AGTTGAGCCT 
GTTGATGCCC GCCCAGCTGC AGACAGAGGA CTCACCACAC GACCAGGTTC TGGCTTGACC 
AATGTTAAAA CAGAAGAGGT ATCTGAAGTA AAGATGGATG CGGAGTTCCG ACATGACTCA 
GGATATGAAG TGCATCATCA AAAGCTGGTG TTCTTTGCTG AAGATGTGGG TTCAAATAAA 
GGTGCCATCA TTGGACTAAT GGTGGGAGGT GTTGTCATAG CGACAGTGAT TGTCATTACT 
CTGGTGATGC TGAAGAAGAA GCAGTACACA TCTATTCATC ATGGGGTTGT GGAGGTGGAT 
GCTGCAGTGA CACCAGAGGA GCGCCACCTC TCCAAGATGC AGCAGAACGG CTACGAGAAC 
CCCACCTACA AGTTCTTCGA ACAGATGCAG AATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

APP ( XM_015299094.1 ) cDNA ORF clone, Gallus gallus(chicken) -> XP_015154580.1 Gallus gallus amyloid beta (A4) precursor protein (APP), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OGa30230
Clone ID Related Accession (Same CDS sequence)	XM_015299094.1 , XM_015299094.2
Accession Version	XM_015299094.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2088bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1451750400000
Organism	Gallus gallus(chicken)
Product	amyloid beta A4 protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_455735.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Gallus gallus Annotation Release 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGCCCC ACTTAGCCCT TTTGCTGCTG GCCGCCGGCG CCGCCCGGGC CCTTGAGGTG 
CCTGCTGATG GAAATGCTGG ATTGTTGGCA GAGCCTCAAA TTGCCATGTT CTGTGGCAAA 
CTCAATATGC ACATGAATGT TCAGAACGGA AAATGGGAAT CTGACCCCTC TGGGACCAAG 
ACCTGTATCG GCACTAAAGA AGGGATTCTG CAGTATTGCC AGGAAGTTTA CCCTGAATTG 
CAAATTACCA ATGTTGTCGA AGCCAACCAG CCGGTTACAA TCCAGAATTG GTGCAAGAGA 
GGATGGAAGC AGTGCAATGG TCACCCACAT ATTGTGGTTC CCTACAGGTG TTTGGTGGGT 
GAGTTTGTGA GTGATGCCCT TCTGGTACCG GACAAGTGCA AGTTCCTTCA CCAGGAAAGG 
ATGGATGTGT GTGAAACTCA CCTGCACTGG CATACTGTTG CTAAAGAGTC CTGCAGCGAG 
AAGAGTATGA ATCTGCATGA CTATGGCATG CTGCTGCCCT GTGGAATTGA CAAGTTTCGT 
GGTGTGGAAT TTGTTTGCTG CCCATTAGCA GAGGAAAGCG ACAATCTTGA CTCAGCTGAT 
GCTGAAGATG ATGATTCAGA TGTCTGGTGG GGAGGCGCAG ATGCAGACTA TGCAGATGGA 
AGCGATGATA AGGTAGTAGA AGAACAACCA GAGGAAGATG AGGAGCTAAC TGTTGTGGAA 
GATGAAGATG CTGATGATGA TGACGATGAT GATGGTGATG AAATTGAAGA GACAGAGGAG 
GAGTATGAGG AAGCAACAGA AAGAACTACC AGTATCGCAA CCACTACCAC CACAACTACA 
GAGTCCGTGG AAGAAGTTGT CAGAGTCCCT ACCACAGCTG CTAGCACTCC TGATGCTGTT 
GACAAATACT TGGAGACACC TGGGGATGAA AATGAACATG CTCATTTCCA GAAAGCCAAG 
GAGAGGCTTG AAGCTAAGCA TCGTGAAAGG ATGTCTCAGG TCATGAGAGA ATGGGAGGAG 
GCAGAACGCC AAGCAAAGAA TTTGCCAAAG GCTGACAAGA AAGCTGTTAT CCAGCATTTC 
CAGGAGAAAG TGGAATCACT GGAACAAGAA GCAGCAAATG AAAGGCAACA GCTTGTGGAG 
ACTCACATGG CACGGGTGGA AGCCATGCTG AATGACCGTC GCCGCATTGC TCTGGAGAAC 
TACATTACAG CACTGCAGAC TGTCCCACCC AGACCTCGTC ACGTATTCAA CATGTTGAAG 
AAGTATGTGC GTGCTGAGCA GAAAGACAGA CAGCATACTC TCAAACACTT CGAACATGTC 
CGGATGGTAG ACCCAAAGAA AGCTGCCCAG ATTAGATCTC AGGTTATGAC ACATCTACGT 
GTGATATACG AACGCATGAA CCAGTCTCTC TCCTTCCTCT ACAATGTGCC TGCTGTAGCT 
GAGGAGATCC AGGATGAAGT CGATGAGTTG CTTCAGAAAG AGCAAAACTA CTCTGACGAT 
GTTCTGGCCA ATATGATCAG CGAACCTAGA ATCAGCTATG GAAATGATGC TCTCATGCCT 
TCATTGACGG AAACTAAGAC CACAGTTGAA CTTCTTCCAG TGGATGGAGA GTTCAGTCTC 
GATGACCTTC AGCCATGGCA TCCCTTTGGT GTTGATTCTG TTCCAGCCAA TACTGAAAAT 
GAAGTTGAGC CTGTTGATGC CCGCCCAGCT GCAGACAGAG GACTCACCAC ACGACCAGGT 
TCTGGCTTGA CCAATGTTAA AACAGAAGAG GTATCTGAAG TAAAGATGGA TGCGGAGTTC 
CGACATGACT CAGGATATGA AGTGCATCAT CAAAAGCTGG TGTTCTTTGC TGAAGATGTG 
GGTTCAAATA AAGGTGCCAT CATTGGACTA ATGGTGGGAG GTGTTGTCAT AGCGACAGTG 
ATTGTCATTA CTCTGGTGAT GCTGAAGAAG AAGCAGTACA CATCTATTCA TCATGGGGTT 
GTGGAGGTGG ATGCTGCAGT GACACCGGAG GAGCGCCACC TCTCCAAGAT GCAGCAGAAC 
GGCTACGAGA ACCCCACCTA CAAGTTCTTC GAACAGATGC AGAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_015154580.1
CDS	155..2242
Translation	MLPHLALLLLAAGAARALEVPADGNAGLLAEPQIAMFCGKLNMHMNVQNGKWESDPSGTKTCIGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGWKQCNGHPHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKESCSEKSMNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNLDSADAEDDDSDVWWGGADADYADGSDDKVVEEQPEEDEELTVVEDEDADDDDDDDGDEIEETEEEYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRIALENYITALQTVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSFLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVDGEFSLDDLQPWHPFGVDSVPANTENEVEPVDARPAADRGLTTRPGSGLTNVKTEEVSEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN

Target ORF information:

RefSeq Version	XM_015299094.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus amyloid beta (A4) precursor protein (APP), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_015299094.1

ORF Insert Sequence:

ATGCTGCCCC ACTTAGCCCT TTTGCTGCTG GCCGCCGGCG CCGCCCGGGC CCTTGAGGTG 
CCTGCTGATG GAAATGCTGG ATTGTTGGCA GAGCCTCAAA TTGCCATGTT CTGTGGCAAA 
CTCAATATGC ACATGAATGT TCAGAACGGA AAATGGGAAT CTGACCCCTC TGGGACCAAG 
ACCTGTATCG GCACTAAAGA AGGGATTCTG CAGTATTGCC AGGAAGTTTA CCCTGAATTG 
CAAATTACCA ATGTTGTCGA AGCCAACCAG CCGGTTACAA TCCAGAATTG GTGCAAGAGA 
GGATGGAAGC AGTGCAATGG TCACCCACAT ATTGTGGTTC CCTACAGGTG TTTGGTGGGT 
GAGTTTGTGA GTGATGCCCT TCTGGTACCG GACAAGTGCA AGTTCCTTCA CCAGGAAAGG 
ATGGATGTGT GTGAAACTCA CCTGCACTGG CATACTGTTG CTAAAGAGTC CTGCAGCGAG 
AAGAGTATGA ATCTGCATGA CTATGGCATG CTGCTGCCCT GTGGAATTGA CAAGTTTCGT 
GGTGTGGAAT TTGTTTGCTG CCCATTAGCA GAGGAAAGCG ACAATCTTGA CTCAGCTGAT 
GCTGAAGATG ATGATTCAGA TGTCTGGTGG GGAGGCGCAG ATGCAGACTA TGCAGATGGA 
AGCGATGATA AGGTAGTAGA AGAACAACCA GAGGAAGATG AGGAGCTAAC TGTTGTGGAA 
GATGAAGATG CTGATGATGA TGACGATGAT GATGGTGATG AAATTGAAGA GACAGAGGAG 
GAGTATGAGG AAGCAACAGA AAGAACTACC AGTATCGCAA CCACTACCAC CACAACTACA 
GAGTCCGTGG AAGAAGTTGT CAGAGTCCCT ACCACAGCTG CTAGCACTCC TGATGCTGTT 
GACAAATACT TGGAGACACC TGGGGATGAA AATGAACATG CTCATTTCCA GAAAGCCAAG 
GAGAGGCTTG AAGCTAAGCA TCGTGAAAGG ATGTCTCAGG TCATGAGAGA ATGGGAGGAG 
GCAGAACGCC AAGCAAAGAA TTTGCCAAAG GCTGACAAGA AAGCTGTTAT CCAGCATTTC 
CAGGAGAAAG TGGAATCACT GGAACAAGAA GCAGCAAATG AAAGGCAACA GCTTGTGGAG 
ACTCACATGG CACGGGTGGA AGCCATGCTG AATGACCGTC GCCGCATTGC TCTGGAGAAC 
TACATTACAG CACTGCAGAC TGTCCCACCC AGACCTCGTC ACGTATTCAA CATGTTGAAG 
AAGTATGTGC GTGCTGAGCA GAAAGACAGA CAGCATACTC TCAAACACTT CGAACATGTC 
CGGATGGTAG ACCCAAAGAA AGCTGCCCAG ATTAGATCTC AGGTTATGAC ACATCTACGT 
GTGATATACG AACGCATGAA CCAGTCTCTC TCCTTCCTCT ACAATGTGCC TGCTGTAGCT 
GAGGAGATCC AGGATGAAGT CGATGAGTTG CTTCAGAAAG AGCAAAACTA CTCTGACGAT 
GTTCTGGCCA ATATGATCAG CGAACCTAGA ATCAGCTATG GAAATGATGC TCTCATGCCT 
TCATTGACGG AAACTAAGAC CACAGTTGAA CTTCTTCCAG TGGATGGAGA GTTCAGTCTC 
GATGACCTTC AGCCATGGCA TCCCTTTGGT GTTGATTCTG TTCCAGCCAA TACTGAAAAT 
GAAGTTGAGC CTGTTGATGC CCGCCCAGCT GCAGACAGAG GACTCACCAC ACGACCAGGT 
TCTGGCTTGA CCAATGTTAA AACAGAAGAG GTATCTGAAG TAAAGATGGA TGCGGAGTTC 
CGACATGACT CAGGATATGA AGTGCATCAT CAAAAGCTGG TGTTCTTTGC TGAAGATGTG 
GGTTCAAATA AAGGTGCCAT CATTGGACTA ATGGTGGGAG GTGTTGTCAT AGCGACAGTG 
ATTGTCATTA CTCTGGTGAT GCTGAAGAAG AAGCAGTACA CATCTATTCA TCATGGGGTT 
GTGGAGGTGG ATGCTGCAGT GACACCGGAG GAGCGCCACC TCTCCAAGAT GCAGCAGAAC 
GGCTACGAGA ACCCCACCTA CAAGTTCTTC GAACAGATGC AGAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

APP ( XM_015299094.2 ) cDNA ORF clone, Gallus gallus(chicken) -> XP_015154580.1 Gallus gallus amyloid beta (A4) precursor protein (APP), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OGa30230
Clone ID Related Accession (Same CDS sequence)	XM_015299094.1 , XM_015299094.2
Accession Version	XM_015299094.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2088bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1526400000000
Organism	Gallus gallus(chicken)
Product	amyloid-beta A4 protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006088.5) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 17, 2018 this sequence version replaced XM_015299094.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 104 Annotation Version :: 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGCCCC ACTTAGCCCT TTTGCTGCTG GCCGCCGGCG CCGCCCGGGC CCTTGAGGTG 
CCTGCTGATG GAAATGCTGG ATTGTTGGCA GAGCCTCAAA TTGCCATGTT CTGTGGCAAA 
CTCAATATGC ACATGAATGT TCAGAACGGA AAATGGGAAT CTGACCCCTC TGGGACCAAG 
ACCTGTATCG GCACTAAAGA AGGGATTCTG CAGTATTGCC AGGAAGTTTA CCCTGAATTG 
CAAATTACCA ATGTTGTCGA AGCCAACCAG CCGGTTACAA TCCAGAATTG GTGCAAGAGA 
GGATGGAAGC AGTGCAATGG TCACCCACAT ATTGTGGTTC CCTACAGGTG TTTGGTGGGT 
GAGTTTGTGA GTGATGCCCT TCTGGTACCG GACAAGTGCA AGTTCCTTCA CCAGGAAAGG 
ATGGATGTGT GTGAAACTCA CCTGCACTGG CATACTGTTG CTAAAGAGTC CTGCAGCGAG 
AAGAGTATGA ATCTGCATGA CTATGGCATG CTGCTGCCCT GTGGAATTGA CAAGTTTCGT 
GGTGTGGAAT TTGTTTGCTG CCCATTAGCA GAGGAAAGCG ACAATCTTGA CTCAGCTGAT 
GCTGAAGATG ATGATTCAGA TGTCTGGTGG GGAGGCGCAG ATGCAGACTA TGCAGATGGA 
AGCGATGATA AGGTAGTAGA AGAACAACCA GAGGAAGATG AGGAGCTAAC TGTTGTGGAA 
GATGAAGATG CTGATGATGA TGACGATGAT GATGGTGATG AAATTGAAGA GACAGAGGAG 
GAGTATGAGG AAGCAACAGA AAGAACTACC AGTATCGCAA CCACTACCAC CACAACTACA 
GAGTCCGTGG AAGAAGTTGT CAGAGTCCCT ACCACAGCTG CTAGCACTCC TGATGCTGTT 
GACAAATACT TGGAGACACC TGGGGATGAA AATGAACATG CTCATTTCCA GAAAGCCAAG 
GAGAGGCTTG AAGCTAAGCA TCGTGAAAGG ATGTCTCAGG TCATGAGAGA ATGGGAGGAG 
GCAGAACGCC AAGCAAAGAA TTTGCCAAAG GCTGACAAGA AAGCTGTTAT CCAGCATTTC 
CAGGAGAAAG TGGAATCACT GGAACAAGAA GCAGCAAATG AAAGGCAACA GCTTGTGGAG 
ACTCACATGG CACGGGTGGA AGCCATGCTG AATGACCGTC GCCGCATTGC TCTGGAGAAC 
TACATTACAG CACTGCAGAC TGTCCCACCC AGACCTCGTC ACGTATTCAA CATGTTGAAG 
AAGTATGTGC GTGCTGAGCA GAAAGACAGA CAGCATACTC TCAAACACTT CGAACATGTC 
CGGATGGTAG ACCCAAAGAA AGCTGCCCAG ATTAGATCTC AGGTTATGAC ACATCTACGT 
GTGATATACG AACGCATGAA CCAGTCTCTC TCCTTCCTCT ACAATGTGCC TGCTGTAGCT 
GAGGAGATCC AGGATGAAGT CGATGAGTTG CTTCAGAAAG AGCAAAACTA CTCTGACGAT 
GTTCTGGCCA ATATGATCAG CGAACCTAGA ATCAGCTATG GAAATGATGC TCTCATGCCT 
TCATTGACGG AAACTAAGAC CACAGTTGAA CTTCTTCCAG TGGATGGAGA GTTCAGTCTC 
GATGACCTTC AGCCATGGCA TCCCTTTGGT GTTGATTCTG TTCCAGCCAA TACTGAAAAT 
GAAGTTGAGC CTGTTGATGC CCGCCCAGCT GCAGACAGAG GACTCACCAC ACGACCAGGT 
TCTGGCTTGA CCAATGTTAA AACAGAAGAG GTATCTGAAG TAAAGATGGA TGCGGAGTTC 
CGACATGACT CAGGATATGA AGTGCATCAT CAAAAGCTGG TGTTCTTTGC TGAAGATGTG 
GGTTCAAATA AAGGTGCCAT CATTGGACTA ATGGTGGGAG GTGTTGTCAT AGCGACAGTG 
ATTGTCATTA CTCTGGTGAT GCTGAAGAAG AAGCAGTACA CATCTATTCA TCATGGGGTT 
GTGGAGGTGG ATGCTGCAGT GACACCGGAG GAGCGCCACC TCTCCAAGAT GCAGCAGAAC 
GGCTACGAGA ACCCCACCTA CAAGTTCTTC GAACAGATGC AGAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_015154580.1
CDS	151..2238
Translation	MLPHLALLLLAAGAARALEVPADGNAGLLAEPQIAMFCGKLNMHMNVQNGKWESDPSGTKTCIGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGWKQCNGHPHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKESCSEKSMNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNLDSADAEDDDSDVWWGGADADYADGSDDKVVEEQPEEDEELTVVEDEDADDDDDDDGDEIEETEEEYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRIALENYITALQTVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSFLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVDGEFSLDDLQPWHPFGVDSVPANTENEVEPVDARPAADRGLTTRPGSGLTNVKTEEVSEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN

Target ORF information:

RefSeq Version	XM_015299094.2
Organism	Gallus gallus(chicken)
Definition	Gallus gallus amyloid beta (A4) precursor protein (APP), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_015299094.2

ORF Insert Sequence:

ATGCTGCCCC ACTTAGCCCT TTTGCTGCTG GCCGCCGGCG CCGCCCGGGC CCTTGAGGTG 
CCTGCTGATG GAAATGCTGG ATTGTTGGCA GAGCCTCAAA TTGCCATGTT CTGTGGCAAA 
CTCAATATGC ACATGAATGT TCAGAACGGA AAATGGGAAT CTGACCCCTC TGGGACCAAG 
ACCTGTATCG GCACTAAAGA AGGGATTCTG CAGTATTGCC AGGAAGTTTA CCCTGAATTG 
CAAATTACCA ATGTTGTCGA AGCCAACCAG CCGGTTACAA TCCAGAATTG GTGCAAGAGA 
GGATGGAAGC AGTGCAATGG TCACCCACAT ATTGTGGTTC CCTACAGGTG TTTGGTGGGT 
GAGTTTGTGA GTGATGCCCT TCTGGTACCG GACAAGTGCA AGTTCCTTCA CCAGGAAAGG 
ATGGATGTGT GTGAAACTCA CCTGCACTGG CATACTGTTG CTAAAGAGTC CTGCAGCGAG 
AAGAGTATGA ATCTGCATGA CTATGGCATG CTGCTGCCCT GTGGAATTGA CAAGTTTCGT 
GGTGTGGAAT TTGTTTGCTG CCCATTAGCA GAGGAAAGCG ACAATCTTGA CTCAGCTGAT 
GCTGAAGATG ATGATTCAGA TGTCTGGTGG GGAGGCGCAG ATGCAGACTA TGCAGATGGA 
AGCGATGATA AGGTAGTAGA AGAACAACCA GAGGAAGATG AGGAGCTAAC TGTTGTGGAA 
GATGAAGATG CTGATGATGA TGACGATGAT GATGGTGATG AAATTGAAGA GACAGAGGAG 
GAGTATGAGG AAGCAACAGA AAGAACTACC AGTATCGCAA CCACTACCAC CACAACTACA 
GAGTCCGTGG AAGAAGTTGT CAGAGTCCCT ACCACAGCTG CTAGCACTCC TGATGCTGTT 
GACAAATACT TGGAGACACC TGGGGATGAA AATGAACATG CTCATTTCCA GAAAGCCAAG 
GAGAGGCTTG AAGCTAAGCA TCGTGAAAGG ATGTCTCAGG TCATGAGAGA ATGGGAGGAG 
GCAGAACGCC AAGCAAAGAA TTTGCCAAAG GCTGACAAGA AAGCTGTTAT CCAGCATTTC 
CAGGAGAAAG TGGAATCACT GGAACAAGAA GCAGCAAATG AAAGGCAACA GCTTGTGGAG 
ACTCACATGG CACGGGTGGA AGCCATGCTG AATGACCGTC GCCGCATTGC TCTGGAGAAC 
TACATTACAG CACTGCAGAC TGTCCCACCC AGACCTCGTC ACGTATTCAA CATGTTGAAG 
AAGTATGTGC GTGCTGAGCA GAAAGACAGA CAGCATACTC TCAAACACTT CGAACATGTC 
CGGATGGTAG ACCCAAAGAA AGCTGCCCAG ATTAGATCTC AGGTTATGAC ACATCTACGT 
GTGATATACG AACGCATGAA CCAGTCTCTC TCCTTCCTCT ACAATGTGCC TGCTGTAGCT 
GAGGAGATCC AGGATGAAGT CGATGAGTTG CTTCAGAAAG AGCAAAACTA CTCTGACGAT 
GTTCTGGCCA ATATGATCAG CGAACCTAGA ATCAGCTATG GAAATGATGC TCTCATGCCT 
TCATTGACGG AAACTAAGAC CACAGTTGAA CTTCTTCCAG TGGATGGAGA GTTCAGTCTC 
GATGACCTTC AGCCATGGCA TCCCTTTGGT GTTGATTCTG TTCCAGCCAA TACTGAAAAT 
GAAGTTGAGC CTGTTGATGC CCGCCCAGCT GCAGACAGAG GACTCACCAC ACGACCAGGT 
TCTGGCTTGA CCAATGTTAA AACAGAAGAG GTATCTGAAG TAAAGATGGA TGCGGAGTTC 
CGACATGACT CAGGATATGA AGTGCATCAT CAAAAGCTGG TGTTCTTTGC TGAAGATGTG 
GGTTCAAATA AAGGTGCCAT CATTGGACTA ATGGTGGGAG GTGTTGTCAT AGCGACAGTG 
ATTGTCATTA CTCTGGTGAT GCTGAAGAAG AAGCAGTACA CATCTATTCA TCATGGGGTT 
GTGGAGGTGG ATGCTGCAGT GACACCGGAG GAGCGCCACC TCTCCAAGAT GCAGCAGAAC 
GGCTACGAGA ACCCCACCTA CAAGTTCTTC GAACAGATGC AGAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inhibition of choline acetyltransferase as a mechanism for cholinergic dysfunction induced by amyloid-β peptide oligomers.
The Journal of biological chemistry287(23)19377-85(2012 Jun)
Nunes-Tavares N,Santos LE,Stutz B,Brito-Moreira J,Klein WL,Ferreira ST,de Mello FG

Comparison of pharmacological modulation of APP metabolism in primary chicken telencephalic neurons and in a human neuroglioma cell line.
Journal of molecular neuroscience : MN43(3)257-67(2011 Mar)
Czvitkovich S,Duller S,Mathiesen E,Lorenzoni K,Imbimbo BP,Hutter-Paier B,Windisch M,Wronski R

Hen lysozyme amyloid fibrils induce aggregation of erythrocytes and lipid vesicles.
Molecular and cellular biochemistry328(1-2)209-15(2009 Aug)
Chaudhary N,Nagaraj R

The chick embryo appears as a natural model for research in beta-amyloid precursor protein processing.
Neuroscience134(4)1285-300(2005)
Carrodeguas JA,Rodolosse A,Garza MV,Sanz-Clemente A,Pérez-Pé R,Lacosta AM,Domínguez L,Monleón I,Sánchez-Díaz R,Sorribas V,Sarasa M

Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology18(11)1288-90(2004 Aug)
Maloney B,Ge YW,Greig N,Lahiri DK

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APP cDNA ORF clone, Gallus gallus(chicken)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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