cog4 cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	cog4
Entrez Gene ID	569049
Full Name	component of oligomeric golgi complex 4
Synonyms	zgc:136860
General protein information	Preferred Names component of oligomeric golgi complex 4 Names conserved oligomeric Golgi complex subunit 4
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001039823.1	NP_001034912.1	conserved oligomeric Golgi complex subunit 4

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008875	XP_552742.3
Oryza sativa (rice)	Os02g0456000	NP_001172943.1
Bos taurus (cattle)	COG4	NP_001029755.1
Mus musculus (house mouse)	Cog4	NP_598734.1
Gallus gallus (chicken)	COG4	NP_001012793.1
Danio rerio (zebrafish)	cog4	NP_001034912.1
Xenopus tropicalis (tropical clawed frog)	LOC100145689	NP_001120535.1
Canis lupus familiaris (dog)	COG4	XP_546836.1
Homo sapiens (human)	COG4	NP_056201.2
Pan troglodytes (chimpanzee)	COG4	XP_511080.3
Macaca mulatta (Rhesus monkey)	COG4	XP_002808350.1
Rattus norvegicus (Norway rat)	Cog4	NP_001101919.1
Drosophila melanogaster (fruit fly)	CG7456	NP_609413.1
Caenorhabditis elegans (roundworm)	cogc-4	NP_493966.1
Arabidopsis thaliana (thale cress)	AT4G01400	NP_001154198.1

Gene Ontology
Bibliography

Related articles in PubMed

Cog4 is required for protrusion and extension of the epithelium in the developing semicircular canals.
Clément A, Blanco-Sánchez B, Peirce JL, Westerfield M
Mechanisms of development1551-7(2019 02)

A Recurrent De Novo Heterozygous COG4 Substitution Leads to Saul-Wilson Syndrome, Disrupted Vesicular Trafficking, and Altered Proteoglycan Glycosylation.
Ferreira CR, Xia ZJ, Clément A, Parry DA, Davids M, Taylan F, Sharma P, Turgeon CT, Blanco-Sánchez B, Ng BG, Logan CV, Wolfe LA, Solomon BD, Cho MT, Douglas G, Carvalho DR, Bratke H, Haug MG, Phillips JB, Wegner J, Tiemeyer M, Aoki K, , , Nordgren A, Hammarsjö A, Duker AL, Rohena L, Hove HB, Ek J, Adams D, Tifft CJ, Onyekweli T, Weixel T, Macnamara E, Radtke K, Powis Z, Earl D, Gabriel M, Russi AHS, Brick L, Kozenko M, Tham E, Raymond KM, Phillips JA 3rd, Tiller GE, Wilson WG, Hamid R, Malicdan MCV, Nishimura G, Grigelioniene G, Jackson A, Westerfield M, Bober MB, Gahl WA, Freeze HH
American journal of human genetics103(4)553-567(2018 10)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

slc7a6os gene plays a critical role in defined areas of the developing CNS in zebrafish.
Benini A, Cignarella F, Calvarini L, Mantovanelli S, Giacopuzzi E, Zizioli D, Borsani G
PloS one10(3)e0119696(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following cog4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the cog4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa30913	NM_001039823.1 Latest version!	Danio rerio component of oligomeric golgi complex 4 (cog4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

cog4 ( NM_001039823.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001034912.1 Danio rerio component of oligomeric golgi complex 4 (cog4), mRNA.

Price & Availability↑

CloneID	ODa30913
Clone ID Related Accession (Same CDS sequence)	NM_001039823.1
Accession Version	NM_001039823.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2346bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Danio rerio(zebrafish)
Product	conserved oligomeric Golgi complex subunit 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC114292.1. On Mar 17, 2006 this sequence version replaced XM_692411.1. ##Evidence-Data-START## Transcript exon combination :: BC114292.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2168446, SAMEA2168447 [ECO:0000348] ##Evidence-Data-END##

ATGGAAGAAG CAGCTTCACC GGCTCGTCGT CGCGGTGGTC CGGCGGGGGT CTCCGCCGTG 
CAGACCGACA CTATCGAGGC TCTAACTGAG CTGGAGGATC TGGAGCGGGT CTACGCGCAG 
CTGTGTGCCG AAGAGGCGGA AGTGCAGGTG GAGTTGGACG CTCTTGTGGG ACAACAGAAC 
AACATCGAAA CAAAGATGCT CTCCCTGCAG AGGATGGGAC CCAACCTGCA GCTGATCGAG 
GGAGACGCTG TGCAGCTCTC TGGCATGATC AACTTCACAT GCAGCCTGGC AGAAAATGTC 
AGCAGCAAAG TCAGACAGCT GGATCTCACC AAGAAAAGGC TGTACCAAGC GATTCAGCGG 
GCTGATGATA TTCTGGACTT GAAATTCTGC ACAGATGGTG TTCAGACTGC CCTGCGGAAT 
CAGGACTATG AACAGGCCGC TGCCCACATT CATCGCTACC TTTCTCTTGA CCAGTCTGTG 
ATCGAGCTCA GCAAGCAGGG TGGAGAGGGC AGTGCAGTTG AAGCCAGCCT TGCGTTGCTT 
CAGGAGGCAG AGCGCAATCT GAAGACACTG GTTACCACTC GTCTGGAGGA AGCAGTTGCC 
ACAGGCGACT TGCCTCAAGT TGAGCGCTTT TTCAAGATCC TTCCTTTACT AGGACTCCAT 
GAGCAGGGAC TTGCACGCTT TGCTCAGTAC CTTTGCAGTC AGTTGGCCAG TAAGGCAGAG 
GAGAATTTAA TCTTGGCCGT TGGCTCTGAT CTCGGTGAAC GCAGAGCACC TGTGATCTTT 
GCTGACACTC TTACACTGCT GCTCGAAGGC ATTGCACGCA TTGTAGAAAC CCATCAGCCA 
ATAGTGGAGA CATACTATGG ACCGGGCCGC CTGCACACAC TTCTCGCGCA CCTTCAGAAA 
GAGTGTGACA AACAGGCTCA GAAAATAGTG GACAAATTCA TCCAACAGAG GGATTACAAC 
AATAAGTTTC AGGTTGTCCA GAGCAACATG ATGAGGGGCA TGACTACGGA TAAGATCGAA 
CCCAGAGACC TGGATCCTGT GTTATGTGAG GTTACCTTAA TGAACTCAAG AGCTGAGTTG 
TATTTCCGAT TCTTGAGGCG GCGTATAGTC GCTGACTTCG AGGTTGCAGA TGCCATGGCG 
GATGAAGCGG TTATACAAGA GCATCAGCAG AGTTTAGAAC AGTTACTGAA GAATTGCCAG 
CTGAGTCGCA CTATGCAGGA GCTGATTGGC TATTACATTC CTATGGAGGA GTATTACATG 
AGAGAGTCTG TCAACAAGGC CGTTGCGATG GACACCGCTG AGGTGGGACA GCTGAGCTCA 
AGCGTGGTGG ATGATGTTTT CTACATTGTA AAGAAATGCA TCAGTCGGGC ACTCACCAGC 
AGCAGCTCTG ACTGTGTGTG TGCCATGATC AATCATGCAA CCAGTGTTCT GGAGACAGAC 
TTCAGGGAGG TGCTAGTATG CAAGTTGCGG GCGGGATATC CCGTCAGTGC TCTGCAGGAC 
CTGCAGCGAG GGGTCAGCAG TGCCGTCAGC CTGATGCAGA GCAGCCTGCA GCAGGGCAAG 
ATAACGAACC TCACACAAAC CCTCGGCATT GAGAGCCAGG AGCAAGCCAA GAGCGCATAC 
TTGGTGACCC TCAATAATGT GGAGGTCTGC AGTGAGAATA TCAGCACCCT GAAAAAGAAT 
CTCGAGAGTG ATTGTGCCAA GCTGTTCAGC CAGGGAGCCA GCTCAGATCA TGCCAAGGAG 
AAGATCGACA GCTGTCTGTC GGATCTGGTC AACACCTCCA GCAAATTCAA AGACCTCCTC 
CAGGAGGGTC TACAGGAGCT TAACAACACT GCTATCAGGC CACAAGTAAA GCCCTGGATC 
AGCAGCTTCC TGTCTGTCTC GCACAATATT GAAGAGGAAG AGTTTAGTGA GTATGAAGCC 
AATGATCCCT TTGTTCAGCA ACTCATTGTC CAGTTGGAGC AGCTTATGGC TGAGTTTAAG 
GTCGGACTGT CACCGGTCAT CTATGATACT CTGACTAGCC TGATGACCAG CCTAATTGCA 
ATGGAGATGG AGAAGACTGT GTTCAAATGC ACCTTCAGCA GGCTCGGTGG ATTACAGTTT 
GATAAGGAGC TGCGGGCTTT GGTCGCATAC TTGTCTTCCG TCACTTCTTG GACCATCCGG 
GATAAGTTTG CCCGACTCAC ACAGATGGCA ACTATACTGA ATCTAGAGAG GGTGTCTGAG 
ATCCTGGATT ATTGGGGACC CAACTCTGGA CCTTTGACGT GGCGTTTGAC CCCGGCTGAG 
GTTCGCCAGG TCTTGGCTCT AAGGGTAGAT TTCCGCAGTG AGGACATTAA AAGATTACGA 
CTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001034912.1
CDS	16..2361
Translation	MEEAASPARRRGGPAGVSAVQTDTIEALTELEDLERVYAQLCAEEAEVQVELDALVGQQNNIETKMLSLQRMGPNLQLIEGDAVQLSGMINFTCSLAENVSSKVRQLDLTKKRLYQAIQRADDILDLKFCTDGVQTALRNQDYEQAAAHIHRYLSLDQSVIELSKQGGEGSAVEASLALLQEAERNLKTLVTTRLEEAVATGDLPQVERFFKILPLLGLHEQGLARFAQYLCSQLASKAEENLILAVGSDLGERRAPVIFADTLTLLLEGIARIVETHQPIVETYYGPGRLHTLLAHLQKECDKQAQKIVDKFIQQRDYNNKFQVVQSNMMRGMTTDKIEPRDLDPVLCEVTLMNSRAELYFRFLRRRIVADFEVADAMADEAVIQEHQQSLEQLLKNCQLSRTMQELIGYYIPMEEYYMRESVNKAVAMDTAEVGQLSSSVVDDVFYIVKKCISRALTSSSSDCVCAMINHATSVLETDFREVLVCKLRAGYPVSALQDLQRGVSSAVSLMQSSLQQGKITNLTQTLGIESQEQAKSAYLVTLNNVEVCSENISTLKKNLESDCAKLFSQGASSDHAKEKIDSCLSDLVNTSSKFKDLLQEGLQELNNTAIRPQVKPWISSFLSVSHNIEEEEFSEYEANDPFVQQLIVQLEQLMAEFKVGLSPVIYDTLTSLMTSLIAMEMEKTVFKCTFSRLGGLQFDKELRALVAYLSSVTSWTIRDKFARLTQMATILNLERVSEILDYWGPNSGPLTWRLTPAEVRQVLALRVDFRSEDIKRLRL

Target ORF information:

RefSeq Version	NM_001039823.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio component of oligomeric golgi complex 4 (cog4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001039823.1

ORF Insert Sequence:

ATGGAAGAAG CAGCTTCACC GGCTCGTCGT CGCGGTGGTC CGGCGGGGGT CTCCGCCGTG 
CAGACCGACA CTATCGAGGC TCTAACTGAG CTGGAGGATC TGGAGCGGGT CTACGCGCAG 
CTGTGTGCCG AAGAGGCGGA AGTGCAGGTG GAGTTGGACG CTCTTGTGGG ACAACAGAAC 
AACATCGAAA CAAAGATGCT CTCCCTGCAG AGGATGGGAC CCAACCTGCA GCTGATCGAG 
GGAGACGCTG TGCAGCTCTC TGGCATGATC AACTTCACAT GCAGCCTGGC AGAAAATGTC 
AGCAGCAAAG TCAGACAGCT GGATCTCACC AAGAAAAGGC TGTACCAAGC GATTCAGCGG 
GCTGATGATA TTCTGGACTT GAAATTCTGC ACAGATGGTG TTCAGACTGC CCTGCGGAAT 
CAGGACTATG AACAGGCCGC TGCCCACATT CATCGCTACC TTTCTCTTGA CCAGTCTGTG 
ATCGAGCTCA GCAAGCAGGG TGGAGAGGGC AGTGCAGTTG AAGCCAGCCT TGCGTTGCTT 
CAGGAGGCAG AGCGCAATCT GAAGACACTG GTTACCACTC GTCTGGAGGA AGCAGTTGCC 
ACAGGCGACT TGCCTCAAGT TGAGCGCTTT TTCAAGATCC TTCCTTTACT AGGACTCCAT 
GAGCAGGGAC TTGCACGCTT TGCTCAGTAC CTTTGCAGTC AGTTGGCCAG TAAGGCAGAG 
GAGAATTTAA TCTTGGCCGT TGGCTCTGAT CTCGGTGAAC GCAGAGCACC TGTGATCTTT 
GCTGACACTC TTACACTGCT GCTCGAAGGC ATTGCACGCA TTGTAGAAAC CCATCAGCCA 
ATAGTGGAGA CATACTATGG ACCGGGCCGC CTGCACACAC TTCTCGCGCA CCTTCAGAAA 
GAGTGTGACA AACAGGCTCA GAAAATAGTG GACAAATTCA TCCAACAGAG GGATTACAAC 
AATAAGTTTC AGGTTGTCCA GAGCAACATG ATGAGGGGCA TGACTACGGA TAAGATCGAA 
CCCAGAGACC TGGATCCTGT GTTATGTGAG GTTACCTTAA TGAACTCAAG AGCTGAGTTG 
TATTTCCGAT TCTTGAGGCG GCGTATAGTC GCTGACTTCG AGGTTGCAGA TGCCATGGCG 
GATGAAGCGG TTATACAAGA GCATCAGCAG AGTTTAGAAC AGTTACTGAA GAATTGCCAG 
CTGAGTCGCA CTATGCAGGA GCTGATTGGC TATTACATTC CTATGGAGGA GTATTACATG 
AGAGAGTCTG TCAACAAGGC CGTTGCGATG GACACCGCTG AGGTGGGACA GCTGAGCTCA 
AGCGTGGTGG ATGATGTTTT CTACATTGTA AAGAAATGCA TCAGTCGGGC ACTCACCAGC 
AGCAGCTCTG ACTGTGTGTG TGCCATGATC AATCATGCAA CCAGTGTTCT GGAGACAGAC 
TTCAGGGAGG TGCTAGTATG CAAGTTGCGG GCGGGATATC CCGTCAGTGC TCTGCAGGAC 
CTGCAGCGAG GGGTCAGCAG TGCCGTCAGC CTGATGCAGA GCAGCCTGCA GCAGGGCAAG 
ATAACGAACC TCACACAAAC CCTCGGCATT GAGAGCCAGG AGCAAGCCAA GAGCGCATAC 
TTGGTGACCC TCAATAATGT GGAGGTCTGC AGTGAGAATA TCAGCACCCT GAAAAAGAAT 
CTCGAGAGTG ATTGTGCCAA GCTGTTCAGC CAGGGAGCCA GCTCAGATCA TGCCAAGGAG 
AAGATCGACA GCTGTCTGTC GGATCTGGTC AACACCTCCA GCAAATTCAA AGACCTCCTC 
CAGGAGGGTC TACAGGAGCT TAACAACACT GCTATCAGGC CACAAGTAAA GCCCTGGATC 
AGCAGCTTCC TGTCTGTCTC GCACAATATT GAAGAGGAAG AGTTTAGTGA GTATGAAGCC 
AATGATCCCT TTGTTCAGCA ACTCATTGTC CAGTTGGAGC AGCTTATGGC TGAGTTTAAG 
GTCGGACTGT CACCGGTCAT CTATGATACT CTGACTAGCC TGATGACCAG CCTAATTGCA 
ATGGAGATGG AGAAGACTGT GTTCAAATGC ACCTTCAGCA GGCTCGGTGG ATTACAGTTT 
GATAAGGAGC TGCGGGCTTT GGTCGCATAC TTGTCTTCCG TCACTTCTTG GACCATCCGG 
GATAAGTTTG CCCGACTCAC ACAGATGGCA ACTATACTGA ATCTAGAGAG GGTGTCTGAG 
ATCCTGGATT ATTGGGGACC CAACTCTGGA CCTTTGACGT GGCGTTTGAC CCCGGCTGAG 
GTTCGCCAGG TCTTGGCTCT AAGGGTAGAT TTCCGCAGTG AGGACATTAA AAGATTACGA 
CTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cog4 is required for protrusion and extension of the epithelium in the developing semicircular canals.
Mechanisms of development1551-7(2019 02)
Clément A,Blanco-Sánchez B,Peirce JL,Westerfield M

A Recurrent De Novo Heterozygous COG4 Substitution Leads to Saul-Wilson Syndrome, Disrupted Vesicular Trafficking, and Altered Proteoglycan Glycosylation.
American journal of human genetics103(4)553-567(2018 10)
Ferreira CR,Xia ZJ,Clément A,Parry DA,Davids M,Taylan F,Sharma P,Turgeon CT,Blanco-Sánchez B,Ng BG,Logan CV,Wolfe LA,Solomon BD,Cho MT,Douglas G,Carvalho DR,Bratke H,Haug MG,Phillips JB,Wegner J,Tiemeyer M,Aoki K,,,Nordgren A,Hammarsjö A,Duker AL,Rohena L,Hove HB,Ek J,Adams D,Tifft CJ,Onyekweli T,Weixel T,Macnamara E,Radtke K,Powis Z,Earl D,Gabriel M,Russi AHS,Brick L,Kozenko M,Tham E,Raymond KM,Phillips JA 3rd,Tiller GE,Wilson WG,Hamid R,Malicdan MCV,Nishimura G,Grigelioniene G,Jackson A,Westerfield M,Bober MB,Gahl WA,Freeze HH

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

slc7a6os gene plays a critical role in defined areas of the developing CNS in zebrafish.
PloS one10(3)e0119696(2015)
Benini A,Cignarella F,Calvarini L,Mantovanelli S,Giacopuzzi E,Zizioli D,Borsani G

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cog4 cDNA ORF clone, Danio rerio(zebrafish)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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