lifra cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	lifra
Entrez Gene ID	541493
Full Name	leukemia inhibitory factor receptor alpha a
Synonyms	lifr.a,zgc:112989
General protein information	Preferred Names leukemia inhibitory factor receptor alpha a Names leukemia inhibitory factor receptor alpha a leukemia inhibitory factor receptor.a
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001014306.2	NP_001014328.2	leukemia inhibitory factor receptor alpha a precursor

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	lifr	XP_004910506.1
Pan troglodytes (chimpanzee)	LIFR	XP_001142123.1
Bos taurus (cattle)	LIFR	NP_001179192.1
Gallus gallus (chicken)	LIFR	NP_989906.1
Homo sapiens (human)	LIFR	NP_002301.1
Canis lupus familiaris (dog)	LIFR	NP_001005760.1
Rattus norvegicus (Norway rat)	Lifr	NP_112310.1
Danio rerio (zebrafish)	lifra	NP_001014328.1
Danio rerio (zebrafish)	lifrb	NP_001107204.1
Macaca mulatta (Rhesus monkey)	LIFR	XP_001082842.2
Mus musculus (house mouse)	Lifr	NP_038612.1

Gene Ontology
Bibliography

Related articles in PubMed

Histone Deacetylase-Mediated Müller Glia Reprogramming through Her4.1-Lin28a Axis Is Essential for Retina Regeneration in Zebrafish.
Mitra S, Sharma P, Kaur S, Khursheed MA, Gupta S, Ahuja R, Kurup AJ, Chaudhary M, Ramachandran R
iScience768-84(2018 Sep)

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)

Leptin and IL-6 family cytokines synergize to stimulate Müller glia reprogramming and retina regeneration.
Zhao XF, Wan J, Powell C, Ramachandran R, Myers MG Jr, Goldman D
Cell reports9(1)272-284(2014 Oct)

Upregulation of leukemia inhibitory factor (LIF) during the early stage of optic nerve regeneration in zebrafish.
Ogai K, Kuwana A, Hisano S, Nagashima M, Koriyama Y, Sugitani K, Mawatari K, Nakashima H, Kato S
PloS one9(8)e106010(2014)

Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration.
Fang Y, Gupta V, Karra R, Holdway JE, Kikuchi K, Poss KD
Proceedings of the National Academy of Sciences of the United States of America110(33)13416-21(2013 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following lifra gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the lifra cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa41642	NM_001014306.2 Latest version!	Danio rerio LIF receptor subunit alpha a (lifra), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

lifra ( NM_001014306.2 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001014328.2 Danio rerio LIF receptor subunit alpha a (lifra), mRNA.

Price & Availability↑

CloneID	ODa41642
Clone ID Related Accession (Same CDS sequence)	NM_001014306.2
Accession Version	NM_001014306.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2793bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1555862400000
Organism	Danio rerio(zebrafish)
Product	leukemia inhibitory factor receptor alpha a precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR318610.8. On Aug 19, 2015 this sequence version replaced NM_001014306.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC091862.1, GDQH01000961.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END##

ATGCAGGGCT GGGTGACTCT GGCTGTGTTG CTGAGCCTTG GGGCCGAACA CTCTCATGGA 
CAGAACGGTC TGGGTGAACT TGCAGTGCCC CGTGGTTTAA GCCTACAGCC TGATTTACCT 
ACACAGACTC TCACTTTGAC CTGGCAGAGC GACTCATCGC TTTTTGACAT CGAGATTTTC 
CACACAGAGT TCATGAATGT GGTGCTAAAT GAGACTGTGG CAGTCAATAC CGATCCAGTA 
ACAGGACAGC ATAGTTGGAC CTGGCACTCA CCTTTACCAC TACAGTGCAC TTCTCATTCT 
GTGCAGATCA GAGCACGAAA CCAGCAGTCG ATCAGCCCGT GGAGCCCCCT AGAGACCATT 
CCAGGGTCAG ATATTCCTGA GAGGTCCGGC CCTAATATGT ATCCCCAGGA TAAGGTGGTT 
CTAGTGGGCA GTAACATGAC CTTCTGCTGT ATTGTGAAGG AGAAGGACTC TTTTAAAAGT 
ATCAAGTATG GCGATCGGGA AATGAGCGCC ACACGTTTGA GCAGAAGAGC TTATGCCATT 
ACAGTGAACA ACCAGCCGTC ATCCAACACC ACGGGCACAA ACGTCTTCTG CATCGTCCAG 
AAGTTGACAG CAGTTGATGA GCTGATCACA GGAGCTGTGG TGTTTGTAGG CTATCCGCCA 
GGCGACAAGG AGCTCGTCTG CGAGACTCGG GATCTGGCAT CCGCTAAGTG TTCTTGGAAG 
AAAGGCAGAG ACACTCGCTT GAAAAAGAGG AACAGTCGCA CCAACTACAC CCTTAATGGA 
AGGGTCTGTG GTGAGGCTAA TGAAGGGAAG AGCTGGGAGT GCAGCTCAGA GGTCTGGGAA 
AAAAACTGGA CTCTGGTCGC TCGAAATCCA ATTGGAACAA TCCAGCTCAC TGACTCTGCT 
CAAATTACTG ACCGTGTGCA TCTGCTGGCT CCGGTAAATG TGATGGCAGA TCCAAAGGCC 
TGGAATGCCA CACTGCGCTG GAACTGGACT GTGGAGGCGT ATAAAAAACT GGAGATGATC 
TGCCAGATGA AGCTCATCAG TCGTCAGCTT TCCAGCACAC GTAACTACAG TGGCACAGGT 
TTATCTTCTG TCGTGCTGGA GGATTTGTGG CCTGATGTGG ACTACACTGT GACTGTACGC 
TGCGCCTCTA AACAAAGTTT CTGGAAATGG GGAGATGAGA GCGCCCCCTG CAGGATACGC 
ACCAAAATGG ACTTTCCCGA TGCTCCTGAT GTGTGGATCT GGATGGACAG CAGTAACACA 
GGACGTGTGT TTTGGAAACC TCTGTCTGTT AGTGAAAGTC ACGGTGCACT GATCAGCTAT 
GAAGTTTTCC GAAGCGGCCT GACACCAGTA GTTCTTTCTC CTGGGAACAT TAGCTATCCC 
ATCATGCCTG ACAGCGGCAG TGACATCACC GTTTCTGTGG CAGCACGCAA CCCAAAAGGT 
CTCTCTAAGG CATCGAGTGC GACTGCACCA GCATATAGAG CAGATTCTCA GCTGTCTGTC 
TCTAAGCTGC TTGGCACCGA TGGAAGATTT GATCTGTCCT GGCAGCCGAG TGCCAATGCC 
AGCAGAGGGT ATGTGGTGGA GTGGGTTCCG AGCAGCTGCA GTGGACTCTG CCCCGTCCAG 
TGGGGGAAAG TTCCAGAAAC AAATAACAGC TTCACTATAG AGAGAGAGTC TCTGGAGGAA 
GGAGTGAAGT TCACCGTGTC CGTGTTTGCT CTGTCAGCCG GATCTCCTTC ACTGCTGCAG 
AGGTGGCAGG GATACTCGCA GGAGATGATT CCTTCACGGT CTGTTCGTGA ACTATCAGCC 
AATCAAACTG GCTCGAATGT GTTGTTGTCT TGGAAACCTG CAGAGATGGA CTATCAGCGA 
GGATTTATTC TCGGATACAA CATCTATATG GCGAATGCTG CGCGTCTGGA TCTTATAGCT 
AATCTCTCTG ACCCTGAGGT GCGCTCGTAC AGGTTAAAGG GTTTGTCTCT GAGCTCGTAT 
AAGTTCATAG TGAAGGCCTA CACCTCAGCT GGGGAGGACG CAGGGACGAT GGTGTCCATA 
AAGATGGAGA TGGACACTGC CGACATGTTG TTTGTTGGCA TCCTCGTGCC GTTGGTGTCC 
ATGTTCTCCT GCATCATCCT CATCAGCATC TGCTGCTACA AGAAGCGAGC ATGGGTAAAG 
AAAGCTTTCT ATCCTGAAAT CCCTGGACCT AAAGTACCTG GCAACTGGTC GTCTCCACAG 
GGGCCTCTGG ACATGAAGCC GTCTCCACAC AGTCTGGTCC AGATCGTGGA GAGTCCAGAG 
TGGGATATCA CAAAAGAGAG TCTGGTTTCA GTACCAGAGG AAGAGGAGAA CGAAAACATG 
GAGGTGGACA CAGACTCCGA TGAACCGGCT CTTCTAAAAT ACTACAATCA GGTTGTGGGA 
CACGGCTCTC GCAGCAACCA GATCTCCGAT TCCTCCGGCT CCTCCACGGC CTCAGTGGAC 
TCCACACAGA CCGAGATCAC CTATGCCGGC ATCCAGAGCC CGACATCATC ACAGGGAGCC 
CATAGTGGAG GATACAGGCC TCAAATGCAG CCTTCTGAGA ATCCAGACGA GCCCCAAGAT 
CAGCTGGATG ATGATGATGA TGATGGCTTG AACACAGGAT ATAAACCCCA GTGTTCCTGG 
CAGATGGACT CTCCAGAGGC GGAAAACTTC AGCGGTTCGC TTGGCAGCCC TACATCCATA 
ACATCATCCC AGTTTCTCAT CCCAGAATCC TCAGAGGAGA AACCGCAGTC GTCCAGCAGC 
TGGTTCCACA GTTTTCTCTC TGGGAAATCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001014328.2
CDS	205..2997
Translation	MQGWVTLAVLLSLGAEHSHGQNGLGELAVPRGLSLQPDLPTQTLTLTWQSDSSLFDIEIFHTEFMNVVLNETVAVNTDPVTGQHSWTWHSPLPLQCTSHSVQIRARNQQSISPWSPLETIPGSDIPERSGPNMYPQDKVVLVGSNMTFCCIVKEKDSFKSIKYGDREMSATRLSRRAYAITVNNQPSSNTTGTNVFCIVQKLTAVDELITGAVVFVGYPPGDKELVCETRDLASAKCSWKKGRDTRLKKRNSRTNYTLNGRVCGEANEGKSWECSSEVWEKNWTLVARNPIGTIQLTDSAQITDRVHLLAPVNVMADPKAWNATLRWNWTVEAYKKLEMICQMKLISRQLSSTRNYSGTGLSSVVLEDLWPDVDYTVTVRCASKQSFWKWGDESAPCRIRTKMDFPDAPDVWIWMDSSNTGRVFWKPLSVSESHGALISYEVFRSGLTPVVLSPGNISYPIMPDSGSDITVSVAARNPKGLSKASSATAPAYRADSQLSVSKLLGTDGRFDLSWQPSANASRGYVVEWVPSSCSGLCPVQWGKVPETNNSFTIERESLEEGVKFTVSVFALSAGSPSLLQRWQGYSQEMIPSRSVRELSANQTGSNVLLSWKPAEMDYQRGFILGYNIYMANAARLDLIANLSDPEVRSYRLKGLSLSSYKFIVKAYTSAGEDAGTMVSIKMEMDTADMLFVGILVPLVSMFSCIILISICCYKKRAWVKKAFYPEIPGPKVPGNWSSPQGPLDMKPSPHSLVQIVESPEWDITKESLVSVPEEEENENMEVDTDSDEPALLKYYNQVVGHGSRSNQISDSSGSSTASVDSTQTEITYAGIQSPTSSQGAHSGGYRPQMQPSENPDEPQDQLDDDDDDGLNTGYKPQCSWQMDSPEAENFSGSLGSPTSITSSQFLIPESSEEKPQSSSSWFHSFLSGKS

Target ORF information:

RefSeq Version	NM_001014306.2
Organism	Danio rerio(zebrafish)
Definition	Danio rerio LIF receptor subunit alpha a (lifra), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001014306.2

ORF Insert Sequence:

ATGCAGGGCT GGGTGACTCT GGCTGTGTTG CTGAGCCTTG GGGCCGAACA CTCTCATGGA 
CAGAACGGTC TGGGTGAACT TGCAGTGCCC CGTGGTTTAA GCCTACAGCC TGATTTACCT 
ACACAGACTC TCACTTTGAC CTGGCAGAGC GACTCATCGC TTTTTGACAT CGAGATTTTC 
CACACAGAGT TCATGAATGT GGTGCTAAAT GAGACTGTGG CAGTCAATAC CGATCCAGTA 
ACAGGACAGC ATAGTTGGAC CTGGCACTCA CCTTTACCAC TACAGTGCAC TTCTCATTCT 
GTGCAGATCA GAGCACGAAA CCAGCAGTCG ATCAGCCCGT GGAGCCCCCT AGAGACCATT 
CCAGGGTCAG ATATTCCTGA GAGGTCCGGC CCTAATATGT ATCCCCAGGA TAAGGTGGTT 
CTAGTGGGCA GTAACATGAC CTTCTGCTGT ATTGTGAAGG AGAAGGACTC TTTTAAAAGT 
ATCAAGTATG GCGATCGGGA AATGAGCGCC ACACGTTTGA GCAGAAGAGC TTATGCCATT 
ACAGTGAACA ACCAGCCGTC ATCCAACACC ACGGGCACAA ACGTCTTCTG CATCGTCCAG 
AAGTTGACAG CAGTTGATGA GCTGATCACA GGAGCTGTGG TGTTTGTAGG CTATCCGCCA 
GGCGACAAGG AGCTCGTCTG CGAGACTCGG GATCTGGCAT CCGCTAAGTG TTCTTGGAAG 
AAAGGCAGAG ACACTCGCTT GAAAAAGAGG AACAGTCGCA CCAACTACAC CCTTAATGGA 
AGGGTCTGTG GTGAGGCTAA TGAAGGGAAG AGCTGGGAGT GCAGCTCAGA GGTCTGGGAA 
AAAAACTGGA CTCTGGTCGC TCGAAATCCA ATTGGAACAA TCCAGCTCAC TGACTCTGCT 
CAAATTACTG ACCGTGTGCA TCTGCTGGCT CCGGTAAATG TGATGGCAGA TCCAAAGGCC 
TGGAATGCCA CACTGCGCTG GAACTGGACT GTGGAGGCGT ATAAAAAACT GGAGATGATC 
TGCCAGATGA AGCTCATCAG TCGTCAGCTT TCCAGCACAC GTAACTACAG TGGCACAGGT 
TTATCTTCTG TCGTGCTGGA GGATTTGTGG CCTGATGTGG ACTACACTGT GACTGTACGC 
TGCGCCTCTA AACAAAGTTT CTGGAAATGG GGAGATGAGA GCGCCCCCTG CAGGATACGC 
ACCAAAATGG ACTTTCCCGA TGCTCCTGAT GTGTGGATCT GGATGGACAG CAGTAACACA 
GGACGTGTGT TTTGGAAACC TCTGTCTGTT AGTGAAAGTC ACGGTGCACT GATCAGCTAT 
GAAGTTTTCC GAAGCGGCCT GACACCAGTA GTTCTTTCTC CTGGGAACAT TAGCTATCCC 
ATCATGCCTG ACAGCGGCAG TGACATCACC GTTTCTGTGG CAGCACGCAA CCCAAAAGGT 
CTCTCTAAGG CATCGAGTGC GACTGCACCA GCATATAGAG CAGATTCTCA GCTGTCTGTC 
TCTAAGCTGC TTGGCACCGA TGGAAGATTT GATCTGTCCT GGCAGCCGAG TGCCAATGCC 
AGCAGAGGGT ATGTGGTGGA GTGGGTTCCG AGCAGCTGCA GTGGACTCTG CCCCGTCCAG 
TGGGGGAAAG TTCCAGAAAC AAATAACAGC TTCACTATAG AGAGAGAGTC TCTGGAGGAA 
GGAGTGAAGT TCACCGTGTC CGTGTTTGCT CTGTCAGCCG GATCTCCTTC ACTGCTGCAG 
AGGTGGCAGG GATACTCGCA GGAGATGATT CCTTCACGGT CTGTTCGTGA ACTATCAGCC 
AATCAAACTG GCTCGAATGT GTTGTTGTCT TGGAAACCTG CAGAGATGGA CTATCAGCGA 
GGATTTATTC TCGGATACAA CATCTATATG GCGAATGCTG CGCGTCTGGA TCTTATAGCT 
AATCTCTCTG ACCCTGAGGT GCGCTCGTAC AGGTTAAAGG GTTTGTCTCT GAGCTCGTAT 
AAGTTCATAG TGAAGGCCTA CACCTCAGCT GGGGAGGACG CAGGGACGAT GGTGTCCATA 
AAGATGGAGA TGGACACTGC CGACATGTTG TTTGTTGGCA TCCTCGTGCC GTTGGTGTCC 
ATGTTCTCCT GCATCATCCT CATCAGCATC TGCTGCTACA AGAAGCGAGC ATGGGTAAAG 
AAAGCTTTCT ATCCTGAAAT CCCTGGACCT AAAGTACCTG GCAACTGGTC GTCTCCACAG 
GGGCCTCTGG ACATGAAGCC GTCTCCACAC AGTCTGGTCC AGATCGTGGA GAGTCCAGAG 
TGGGATATCA CAAAAGAGAG TCTGGTTTCA GTACCAGAGG AAGAGGAGAA CGAAAACATG 
GAGGTGGACA CAGACTCCGA TGAACCGGCT CTTCTAAAAT ACTACAATCA GGTTGTGGGA 
CACGGCTCTC GCAGCAACCA GATCTCCGAT TCCTCCGGCT CCTCCACGGC CTCAGTGGAC 
TCCACACAGA CCGAGATCAC CTATGCCGGC ATCCAGAGCC CGACATCATC ACAGGGAGCC 
CATAGTGGAG GATACAGGCC TCAAATGCAG CCTTCTGAGA ATCCAGACGA GCCCCAAGAT 
CAGCTGGATG ATGATGATGA TGATGGCTTG AACACAGGAT ATAAACCCCA GTGTTCCTGG 
CAGATGGACT CTCCAGAGGC GGAAAACTTC AGCGGTTCGC TTGGCAGCCC TACATCCATA 
ACATCATCCC AGTTTCTCAT CCCAGAATCC TCAGAGGAGA AACCGCAGTC GTCCAGCAGC 
TGGTTCCACA GTTTTCTCTC TGGGAAATCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Histone Deacetylase-Mediated Müller Glia Reprogramming through Her4.1-Lin28a Axis Is Essential for Retina Regeneration in Zebrafish.
iScience768-84(2018 Sep)
Mitra S,Sharma P,Kaur S,Khursheed MA,Gupta S,Ahuja R,Kurup AJ,Chaudhary M,Ramachandran R

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
BMC genomics17368(2016 05)
Pasquier J,Cabau C,Nguyen T,Jouanno E,Severac D,Braasch I,Journot L,Pontarotti P,Klopp C,Postlethwait JH,Guiguen Y,Bobe J

Leptin and IL-6 family cytokines synergize to stimulate Müller glia reprogramming and retina regeneration.
Cell reports9(1)272-284(2014 Oct)
Zhao XF,Wan J,Powell C,Ramachandran R,Myers MG Jr,Goldman D

Upregulation of leukemia inhibitory factor (LIF) during the early stage of optic nerve regeneration in zebrafish.
PloS one9(8)e106010(2014)
Ogai K,Kuwana A,Hisano S,Nagashima M,Koriyama Y,Sugitani K,Mawatari K,Nakashima H,Kato S

Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration.
Proceedings of the National Academy of Sciences of the United States of America110(33)13416-21(2013 Aug)
Fang Y,Gupta V,Karra R,Holdway JE,Kikuchi K,Poss KD

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lifra cDNA ORF clone, Danio rerio(zebrafish)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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