gadd45bb cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	gadd45bb
Entrez Gene ID	497646
Full Name	growth arrest and DNA-damage-inducible, beta b
Synonyms	gadd45b1,gadd45bl,zgc:112453
General protein information	Preferred Names growth arrest and DNA-damage-inducible, beta b Names growth arrest and DNA-damage-inducible, beta b growth arrest and DNA-damage-inducible, beta like
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001012386.2	NP_001012386.1	growth arrest and DNA-damage-inducible, beta b

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GADD45B	XP_001151983.1
Canis lupus familiaris (dog)	GADD45B	XP_542187.1
Gallus gallus (chicken)	LOC100859853	XP_003643868.2
Xenopus tropicalis (tropical clawed frog)	gadd45b	XP_002941163.2
Macaca mulatta (Rhesus monkey)	GADD45B	XP_001098598.1
Bos taurus (cattle)	GADD45B	NP_001035694.1
Mus musculus (house mouse)	Gadd45b	NP_032681.1
Danio rerio (zebrafish)	gadd45ba	NP_998196.1
Danio rerio (zebrafish)	gadd45bb	NP_001012386.1
Rattus norvegicus (Norway rat)	Gadd45b	NP_001008322.1
Homo sapiens (human)	GADD45B	NP_056490.2

Gene Ontology
Bibliography

Related articles in PubMed

Comparative effects of cadmium, zinc, arsenic and chromium on olfactory-mediated neurobehavior and gene expression in larval zebrafish (Danio rerio).
Heffern K, Tierney K, Gallagher EP
Aquatic toxicology (Amsterdam, Netherlands)20183-90(2018 Aug)

Tritiated water exposure disrupts myofibril structure and induces mis-regulation of eye opacity and DNA repair genes in zebrafish early life stages.
Arcanjo C, Armant O, Floriani M, Cavalie I, Camilleri V, Simon O, Orjollet D, Adam-Guillermin C, Gagnaire B
Aquatic toxicology (Amsterdam, Netherlands)200114-126(2018 Jul)

Triptolide attenuates proteinuria and podocyte apoptosis via inhibition of NF-κB/GADD45B.
Wang L, Zhang L, Hou Q, Zhu X, Chen Z, Liu Z
Scientific reports8(1)10843(2018 Jul)

Competition between histone and transcription factor binding regulates the onset of transcription in zebrafish embryos.
Joseph SR, Pálfy M, Hilbert L, Kumar M, Karschau J, Zaburdaev V, Shevchenko A, Vastenhouw NL
eLife6(2017 04)

A targeted gene expression platform allows for rapid analysis of chemical-induced antioxidant mRNA expression in zebrafish larvae.
Mills MG, Gallagher EP
PloS one12(2)e0171025(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following gadd45bb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the gadd45bb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa01917	NM_001012386.2 Latest version!	Danio rerio growth arrest and DNA-damage-inducible, beta b (gadd45bb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

gadd45bb ( NM_001012386.2 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001012386.1 Danio rerio growth arrest and DNA-damage-inducible, beta b (gadd45bb), mRNA.

Price & Availability↑

CloneID	ODa01917
Clone ID Related Accession (Same CDS sequence)	NM_001012386.2
Accession Version	NM_001012386.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 477bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1546617600000
Organism	Danio rerio(zebrafish)
Product	growth arrest and DNA-damage-inducible, beta b
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC095819.1. On May 15, 2005 this sequence version replaced NM_001012386.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC095819.1, CN024074.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2168446, SAMEA2168447 [ECO:0000348] ##Evidence-Data-END##

ATGACTCTGG AGGAAGTTGT TGGATGCAAC AGCACTGAGA GAAAAATGGA GACAGTGAGT 
GAAGCTCTGG AGGAGCTGCT AATGGCTGCA CAGCGACAAA ACTGTCTGAC AGTTGGAGTC 
TACGAGTCTG CACAACTCAT GAATGTGGAT CCAGACAGCG TGGTGCTGTG CGTTCTAGCC 
ACCGATGAGG AGGACGAGAA TGATGTTGCG CTTCAGATCC ACTTCACGCT CATCCAAGCC 
TTCTGCTGCG ACATCGACAT CAACATTGTG CGCGTGTCCG GCATGAGGCG TCTGGCACAG 
GTTCTCGAAG AGCCTCTGTC CACTGACAAT AACGCCAATG AACCAAGAGA CCTTCACTGC 
ATACTTGTTA CTAACCCCCA AGCCGAGCAT CTCAAGCTGA AGGAAGTGGG AAGTTACTGC 
AAGGAAAGCC GCTGCAGGAA CCAGTGGGTG CCTTCTATTG CCCTGCAAGA GCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001012386.1
CDS	172..648
Translation	MTLEEVVGCNSTERKMETVSEALEELLMAAQRQNCLTVGVYESAQLMNVDPDSVVLCVLATDEEDENDVALQIHFTLIQAFCCDIDINIVRVSGMRRLAQVLEEPLSTDNNANEPRDLHCILVTNPQAEHLKLKEVGSYCKESRCRNQWVPSIALQER

Target ORF information:

RefSeq Version	NM_001012386.2
Organism	Danio rerio(zebrafish)
Definition	Danio rerio growth arrest and DNA-damage-inducible, beta b (gadd45bb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001012386.2

ORF Insert Sequence:

ATGACTCTGG AGGAAGTTGT TGGATGCAAC AGCACTGAGA GAAAAATGGA GACAGTGAGT 
GAAGCTCTGG AGGAGCTGCT AATGGCTGCA CAGCGACAAA ACTGTCTGAC AGTTGGAGTC 
TACGAGTCTG CACAACTCAT GAATGTGGAT CCAGACAGCG TGGTGCTGTG CGTTCTAGCC 
ACCGATGAGG AGGACGAGAA TGATGTTGCG CTTCAGATCC ACTTCACGCT CATCCAAGCC 
TTCTGCTGCG ACATCGACAT CAACATTGTG CGCGTGTCCG GCATGAGGCG TCTGGCACAG 
GTTCTCGAAG AGCCTCTGTC CACTGACAAT AACGCCAATG AACCAAGAGA CCTTCACTGC 
ATACTTGTTA CTAACCCCCA AGCCGAGCAT CTCAAGCTGA AGGAAGTGGG AAGTTACTGC 
AAGGAAAGCC GCTGCAGGAA CCAGTGGGTG CCTTCTATTG CCCTGCAAGA GCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Comparative effects of cadmium, zinc, arsenic and chromium on olfactory-mediated neurobehavior and gene expression in larval zebrafish (Danio rerio).
Aquatic toxicology (Amsterdam, Netherlands)20183-90(2018 Aug)
Heffern K,Tierney K,Gallagher EP

Tritiated water exposure disrupts myofibril structure and induces mis-regulation of eye opacity and DNA repair genes in zebrafish early life stages.
Aquatic toxicology (Amsterdam, Netherlands)200114-126(2018 Jul)
Arcanjo C,Armant O,Floriani M,Cavalie I,Camilleri V,Simon O,Orjollet D,Adam-Guillermin C,Gagnaire B

Triptolide attenuates proteinuria and podocyte apoptosis via inhibition of NF-κB/GADD45B.
Scientific reports8(1)10843(2018 Jul)
Wang L,Zhang L,Hou Q,Zhu X,Chen Z,Liu Z

Competition between histone and transcription factor binding regulates the onset of transcription in zebrafish embryos.
eLife6(2017 04)
Joseph SR,Pálfy M,Hilbert L,Kumar M,Karschau J,Zaburdaev V,Shevchenko A,Vastenhouw NL

A targeted gene expression platform allows for rapid analysis of chemical-induced antioxidant mRNA expression in zebrafish larvae.
PloS one12(2)e0171025(2017)
Mills MG,Gallagher EP