cyp1a cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	cyp1a
Entrez Gene ID	140634
Full Name	cytochrome P450, family 1, subfamily A
Synonyms	cyp1a1,wu:fb63b04,zfCYP1A,zgc:109747
General protein information	Preferred Names cytochrome P450, family 1, subfamily A Names cytochrome P450 1A1 cytochrome P450, subfamily I, polypeptide 1
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_131879.2	NP_571954.1	cytochrome P450 1A1

Pathways from BioSystems

Homologies

Oryza sativa (rice)	Os04g0101400	NP_001051991.1
Pan troglodytes (chimpanzee)	LOC453744	XP_001137654.1
Bos taurus (cattle)	CYP1A1	XP_005222075.1
Xenopus tropicalis (tropical clawed frog)	cyp1a1	NP_001090813.1
Oryza sativa (rice)	Os06g0613600	NP_001058072.1
Mus musculus (house mouse)	Cyp1a1	NP_001129531.1
Arabidopsis thaliana (thale cress)	CYP93D1	NP_196307.1
Macaca mulatta (Rhesus monkey)	CYP1A1	NP_001035328.1
Gallus gallus (chicken)	CYP1A1	NP_990477.1
Danio rerio (zebrafish)	cyp1a	NP_571954.1
Homo sapiens (human)	CYP1A1	NP_000490.1
Rattus norvegicus (Norway rat)	Cyp1a1	NP_036672.2
Canis lupus familiaris (dog)	CYP1A1	XP_003433938.1
Oryza sativa (rice)	Os06g0102100	NP_001056533.1
Gallus gallus (chicken)	CYP1A4	NP_990478.1

Gene Ontology
Bibliography

Related articles in PubMed

Reversion of tumor hepatocytes to normal hepatocytes during liver tumor regression in an oncogene-expressing transgenic zebrafish model.
Li Y, Agrawal I, Gong Z
Disease models & mechanisms12(10)(2019 10)

The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis.
Lozza L, Moura-Alves P, Domaszewska T, Lage Crespo C, Streata I, Kreuchwig A, Puyskens A, Bechtle M, Klemm M, Zedler U, Silviu Ungureanu B, Guhlich-Bornhof U, Koehler AB, Stäber M, Mollenkopf HJ, Hurwitz R, Furkert J, Krause G, Weiner J 3rd, Jacinto A, Mihai I, Leite-de-Moraes M, Siebenhaar F, Maurer M, Kaufmann SHE
Scientific reports9(1)10878(2019 Jul)

Coupling Genome-wide Transcriptomics and Developmental Toxicity Profiles in Zebrafish to Characterize Polycyclic Aromatic Hydrocarbon (PAH) Hazard.
Shankar P, Geier MC, Truong L, McClure RS, Pande P, Waters KM, Tanguay RL
International journal of molecular sciences20(10)(2019 May)

Assessment of environmentally contaminated sediment using a contact assay with early life stage zebrafish (Danio rerio).
Boulanger E, Barst BD, Alloy MM, Blais S, Houde M, Head JA
The Science of the total environment659950-962(2019 Apr)

Maternal exposure to fipronil results in sulfone metabolite enrichment and transgenerational toxicity in zebrafish offspring: Indication for an overlooked risk in maternal transfer?
Xu C, Niu L, Liu J, Sun X, Zhang C, Ye J, Liu W
Environmental pollution (Barking, Essex : 1987)246876-884(2019 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following cyp1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the cyp1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa98505	NM_131879.2 Latest version!	Danio rerio cytochrome P450, family 1, subfamily A (cyp1a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

cyp1a ( NM_131879.2 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_571954.1 Danio rerio cytochrome P450, family 1, subfamily A (cyp1a), mRNA.

Price & Availability↑

CloneID	ODa98505
Clone ID Related Accession (Same CDS sequence)	NM_131879.2
Accession Version	NM_131879.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1560bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1578067200000
Organism	Danio rerio(zebrafish)
Product	cytochrome P450 1A1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH454923.1, CF997194.1, CU462829.5, EH525844.1 and AI496734.1. On Sep 13, 2016 this sequence version replaced NM_131879.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC094977.1, GDQQ01006051.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END##

ATGGCTCTGA CTATTCTTCC AATATTGGGT CCGATTTCTG TGTCTGAGAG TCTCGTGGCC 
ATTATAACAA TATGTTTGGT GTATCTGCTC ATGCGCCTAA ACCGCACGAA AATCCCAGAC 
GGGCTACAGA AGCTTCCCGG CCCGAAGCCT CTGCCGATTA TCGGAAATGT CCTGGAAATC 
GGAAACAACC CACATTTGAG TCTGACGGCC ATGAGTAAGT GCTATGGCCC GGTTTTCCAG 
ATCCAGATCG GCATGCGTCC TGTCGTCGTA CTCAGTGGGA ATGATGTGAT CCGACAGGCG 
CTCCTAAAAC AGGGCGAAGA GTTTTCCGGA CGTCCAGAAT TGTACAGCAC CAAGTTCATC 
AGTGATGGAA AGAGTCTGGC GTTCAGTACG GATCAAGTCG GAGTCTGGAG AGCACGCCGA 
AAGCTGGCGC TCAATGCCCT GCGAACATTT TCAACAGTGC AGGGAAAGAG TCCCAAATAT 
TCCTGCGCCC TAGAGGAGCA CATCAGTAAT GAGGGTTTAT ATTTGGTCCA GAGGCTGCAC 
TCTGTTATGA AAGCCGATGG AAGCTTTGAT CCATTCAGAC ATATCGTAGT ATCCGTGGCT 
AACGTAATCT GCGGGATCTG TTTCGGACGC CGGCATAGTC ATGATGATGA TGAACTGGTG 
CGACTGGTTA ATATGAGCGA TGAGTTCGGG AAGATCGTGG GCAGCGGAAA CCCTGCCGAT 
TTCATCCCTT TCCTGCGCAT TCTGCCGAGC ACGACGATGA AGAAGTTCCT GGATATCAAC 
GAACGCTTCA GTAAATTCAT GAAGAGGCTG GTGATGGAGC ATTACGATAC GTTCGATAAG 
GACAACATCA GAGACATCAC CGACTCTCTT ATCAACCACT GCGAAGACCG AAAACTGGAC 
GAAAACTCCA ACCTGCAAGT GTCCGATGAG AAGATCGTAG GAATCGTCAA TGACCTATTC 
GGAGCCGGTT TCGACACTAT CAGTACGGCT CTGTCCTGGG CGGTTGTCTA TCTAGTGCAC 
TACCCAGAGG TCCAGGAGCG ACTGCAAAGA GAATTGGATG AAAAGATCGG GAAGGATCGC 
ACACCACTGT TATCTGACAG GGCGAACCTG CCGCTTCTGG AGTCCTTCAT TCTGGAGATC 
TTCCGTCATT CATCCTTCCT TCCCTTCACC ATTCCTCACT GCACATCCAA AGACACGTCA 
CTCAATGGCT ATTTTATTCC CAAAGACACC TGCGTGTTTG TAAACCAGTG GCAAGTCAAC 
CATGACCCAG AACTGTGGAA GGATCCCTCG TCTTTTATTC CCGACCGGTT CCTCACTGCG 
GACGGTACTG AACTGAATAA GTTGGAAGGC GAGAAGGTGT TGGTTTTCGG TTTGGGAAAG 
CGCCGCTGCA TTGGAGAGTC CATCGGACGC GCTGAAGTCT TCCTGTTCCT GGCCATCCTG 
CTGCAAAGGT TAAAGTTCAC CGGGATGCCA GGAGAAATGC TGGATATGAC CCCAGAGTAC 
GGGTTGACCA TGAAACACAA GCGGTGTCTT CTTCGGGTCA CACCACAGCC TGGGTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_571954.1
CDS	87..1646
Translation	MALTILPILGPISVSESLVAIITICLVYLLMRLNRTKIPDGLQKLPGPKPLPIIGNVLEIGNNPHLSLTAMSKCYGPVFQIQIGMRPVVVLSGNDVIRQALLKQGEEFSGRPELYSTKFISDGKSLAFSTDQVGVWRARRKLALNALRTFSTVQGKSPKYSCALEEHISNEGLYLVQRLHSVMKADGSFDPFRHIVVSVANVICGICFGRRHSHDDDELVRLVNMSDEFGKIVGSGNPADFIPFLRILPSTTMKKFLDINERFSKFMKRLVMEHYDTFDKDNIRDITDSLINHCEDRKLDENSNLQVSDEKIVGIVNDLFGAGFDTISTALSWAVVYLVHYPEVQERLQRELDEKIGKDRTPLLSDRANLPLLESFILEIFRHSSFLPFTIPHCTSKDTSLNGYFIPKDTCVFVNQWQVNHDPELWKDPSSFIPDRFLTADGTELNKLEGEKVLVFGLGKRRCIGESIGRAEVFLFLAILLQRLKFTGMPGEMLDMTPEYGLTMKHKRCLLRVTPQPGF

Target ORF information:

RefSeq Version	NM_131879.2
Organism	Danio rerio(zebrafish)
Definition	Danio rerio cytochrome P450, family 1, subfamily A (cyp1a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_131879.2

ORF Insert Sequence:

ATGGCTCTGA CTATTCTTCC AATATTGGGT CCGATTTCTG TGTCTGAGAG TCTCGTGGCC 
ATTATAACAA TATGTTTGGT GTATCTGCTC ATGCGCCTAA ACCGCACGAA AATCCCAGAC 
GGGCTACAGA AGCTTCCCGG CCCGAAGCCT CTGCCGATTA TCGGAAATGT CCTGGAAATC 
GGAAACAACC CACATTTGAG TCTGACGGCC ATGAGTAAGT GCTATGGCCC GGTTTTCCAG 
ATCCAGATCG GCATGCGTCC TGTCGTCGTA CTCAGTGGGA ATGATGTGAT CCGACAGGCG 
CTCCTAAAAC AGGGCGAAGA GTTTTCCGGA CGTCCAGAAT TGTACAGCAC CAAGTTCATC 
AGTGATGGAA AGAGTCTGGC GTTCAGTACG GATCAAGTCG GAGTCTGGAG AGCACGCCGA 
AAGCTGGCGC TCAATGCCCT GCGAACATTT TCAACAGTGC AGGGAAAGAG TCCCAAATAT 
TCCTGCGCCC TAGAGGAGCA CATCAGTAAT GAGGGTTTAT ATTTGGTCCA GAGGCTGCAC 
TCTGTTATGA AAGCCGATGG AAGCTTTGAT CCATTCAGAC ATATCGTAGT ATCCGTGGCT 
AACGTAATCT GCGGGATCTG TTTCGGACGC CGGCATAGTC ATGATGATGA TGAACTGGTG 
CGACTGGTTA ATATGAGCGA TGAGTTCGGG AAGATCGTGG GCAGCGGAAA CCCTGCCGAT 
TTCATCCCTT TCCTGCGCAT TCTGCCGAGC ACGACGATGA AGAAGTTCCT GGATATCAAC 
GAACGCTTCA GTAAATTCAT GAAGAGGCTG GTGATGGAGC ATTACGATAC GTTCGATAAG 
GACAACATCA GAGACATCAC CGACTCTCTT ATCAACCACT GCGAAGACCG AAAACTGGAC 
GAAAACTCCA ACCTGCAAGT GTCCGATGAG AAGATCGTAG GAATCGTCAA TGACCTATTC 
GGAGCCGGTT TCGACACTAT CAGTACGGCT CTGTCCTGGG CGGTTGTCTA TCTAGTGCAC 
TACCCAGAGG TCCAGGAGCG ACTGCAAAGA GAATTGGATG AAAAGATCGG GAAGGATCGC 
ACACCACTGT TATCTGACAG GGCGAACCTG CCGCTTCTGG AGTCCTTCAT TCTGGAGATC 
TTCCGTCATT CATCCTTCCT TCCCTTCACC ATTCCTCACT GCACATCCAA AGACACGTCA 
CTCAATGGCT ATTTTATTCC CAAAGACACC TGCGTGTTTG TAAACCAGTG GCAAGTCAAC 
CATGACCCAG AACTGTGGAA GGATCCCTCG TCTTTTATTC CCGACCGGTT CCTCACTGCG 
GACGGTACTG AACTGAATAA GTTGGAAGGC GAGAAGGTGT TGGTTTTCGG TTTGGGAAAG 
CGCCGCTGCA TTGGAGAGTC CATCGGACGC GCTGAAGTCT TCCTGTTCCT GGCCATCCTG 
CTGCAAAGGT TAAAGTTCAC CGGGATGCCA GGAGAAATGC TGGATATGAC CCCAGAGTAC 
GGGTTGACCA TGAAACACAA GCGGTGTCTT CTTCGGGTCA CACCACAGCC TGGGTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Reversion of tumor hepatocytes to normal hepatocytes during liver tumor regression in an oncogene-expressing transgenic zebrafish model.
Disease models & mechanisms12(10)(2019 10)
Li Y,Agrawal I,Gong Z

The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis.
Scientific reports9(1)10878(2019 Jul)
Lozza L,Moura-Alves P,Domaszewska T,Lage Crespo C,Streata I,Kreuchwig A,Puyskens A,Bechtle M,Klemm M,Zedler U,Silviu Ungureanu B,Guhlich-Bornhof U,Koehler AB,Stäber M,Mollenkopf HJ,Hurwitz R,Furkert J,Krause G,Weiner J 3rd,Jacinto A,Mihai I,Leite-de-Moraes M,Siebenhaar F,Maurer M,Kaufmann SHE

Coupling Genome-wide Transcriptomics and Developmental Toxicity Profiles in Zebrafish to Characterize Polycyclic Aromatic Hydrocarbon (PAH) Hazard.
International journal of molecular sciences20(10)(2019 May)
Shankar P,Geier MC,Truong L,McClure RS,Pande P,Waters KM,Tanguay RL

Assessment of environmentally contaminated sediment using a contact assay with early life stage zebrafish (Danio rerio).
The Science of the total environment659950-962(2019 Apr)
Boulanger E,Barst BD,Alloy MM,Blais S,Houde M,Head JA

Maternal exposure to fipronil results in sulfone metabolite enrichment and transgenerational toxicity in zebrafish offspring: Indication for an overlooked risk in maternal transfer?
Environmental pollution (Barking, Essex : 1987)246876-884(2019 Mar)
Xu C,Niu L,Liu J,Sun X,Zhang C,Ye J,Liu W