CDKN1B cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	CDKN1B
Entrez Gene ID	403429
Full Name	cyclin dependent kinase inhibitor 1B
Synonyms	Kip1,p27,p27Kip1
General protein information	Preferred Names cyclin dependent kinase inhibitor 1B Names cyclin-dependent kinase inhibitor 1B putative cyclin-dependent kinase inhibitor p27
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
XM_005636668.2	XP_005636725.1	cyclin-dependent kinase inhibitor 1B isoform X1
XM_005636668.3	XP_005636725.1	cyclin-dependent kinase inhibitor 1B isoform X1
NM_001002957.2	NP_001002957.2	cyclin-dependent kinase inhibitor 1B

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CDKN1B	XP_522347.3
Canis lupus familiaris (dog)	CDKN1B	NP_001002957.1
Bos taurus (cattle)	CDKN1B	NP_001093816.1
Macaca mulatta (Rhesus monkey)	CDKN1B	XP_001085433.1
Danio rerio (zebrafish)	cdkn1bb	NP_997957.1
Danio rerio (zebrafish)	LOC100534692	XP_003201420.1
Rattus norvegicus (Norway rat)	Cdkn1b	NP_113950.2
Homo sapiens (human)	CDKN1B	NP_004055.1
Mus musculus (house mouse)	Cdkn1b	NP_034005.2
Gallus gallus (chicken)	CDKN1B	NP_989587.1

Gene Ontology
Bibliography

Related articles in PubMed

Serum starvation and thymidine double blocking achieved efficient cell cycle synchronization and altered the expression of p27, p53, bcl-2 in canine breast cancer cells.
Tong J, Sun D, Yang C, Wang Y, Sun S, Li Q, Bao J, Liu Y
Research in veterinary science10510-4(2016 Apr)

A novel mutation in the upstream open reading frame of the CDKN1B gene causes a MEN4 phenotype.
Occhi G, Regazzo D, Trivellin G, Boaretto F, Ciato D, Bobisse S, Ferasin S, Cetani F, Pardi E, Korbonits M, Pellegata NS, Sidarovich V, Quattrone A, Opocher G, Mantero F, Scaroni C
PLoS genetics9(3)e1003350(2013 Mar)

Serine 123 phosphorylation modulates p21 protein stability and activity by suppressing ubiquitin-independent proteasomal degradation.
Chen X, Zhang J, Zhang M, Liu S, Yan W, Jung J, Chen X
The Journal of biological chemistry287(41)34410-8(2012 Oct)

Expression of Ki-67, PCNA, and p27kip1 in canine pituitary corticotroph adenomas.
van Rijn SJ, Grinwis GC, Penning LC, Meij BP
Domestic animal endocrinology38(4)244-52(2010 May)

Differential expression of cell cycle regulators p21, p27 and p53 in metastasizing canine mammary adenocarcinomas versus normal mammary glands.
Klopfleisch R, Gruber AD
Research in veterinary science87(1)91-6(2009 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CDKN1B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDKN1B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OCe26804	NM_001002957.2 Latest version!	Canis lupus familiaris cyclin dependent kinase inhibitor 1B (CDKN1B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OCe26804	XM_005636668.3 Latest version!	Canis lupus familiaris cyclin dependent kinase inhibitor 1B (CDKN1B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OCe26804	XM_005636668.2	Canis lupus familiaris cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CDKN1B ( NM_001002957.2 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001002957.2 Canis lupus familiaris cyclin dependent kinase inhibitor 1B (CDKN1B), mRNA.

Price & Availability↑

CloneID	OCe26804
Clone ID Related Accession (Same CDS sequence)	XM_005636668.2 , XM_005636668.3 , NM_001002957.2
Accession Version	NM_001002957.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577462400000
Organism	Canis lupus familiaris(dog)
Product	cyclin-dependent kinase inhibitor 1B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AAEX03015249.1. On Sep 2, 2015 this sequence version replaced NM_001002957.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: HE804769.1, AY455798.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2240903, SAMEA4547739 [ECO:0000348] ##Evidence-Data-END##

ATGTCAAACG TGCGAGTGTC TAACGGGAGC CCGAGCCTCG AGCGGATGGA CGCCAGACAG 
GCCGAGTACC CCAAGCCCTC CGCCTGCAGG AACCTCTTCG GCCCGGTCAA CCACGAAGAG 
TTGACCCGGG ACTTGGAGAA GCACTGCAGA GACATGGAAG AGGCGAGCCA GCGCAAGTGG 
AATTTTGATT TCCAGAATCA CAAGCCCCTG GAGGGCAAAT ACGAGTGGCA GGAGGTGGAG 
AAGGGCAGCT TGCCCGAGTT CTACTACAGA CCCCCGCGGC CACCCAAAGG CGCCTGCAAG 
GTGCCGGCGC AGGAGAGCCA GGACGTCAGC GGGACCCGCC AGGCGGGGCC TTTACTGGGG 
TCTCAGGCCA ACTCAGAGGA CACACACTTG GTAGACCAAA AGACTGATGC GCCCGACAGC 
CAGACGGGGC TAGCGGAGCA GTGCACTGGG ATCAGGAAGC GACCCGCGAC CGACGATTCC 
TCTCCTCAAA ACAAAAGAGC CAACAGAACA GAAGAAAACG TCTCAGACGG TTCCCCGAAC 
GCGGGTTCAG TGGAGCAGAC GCCCAAGAAG CCGGGCCTCA GAAGACGTCA AACGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001002957.2
CDS	1..597
Translation	MSNVRVSNGSPSLERMDARQAEYPKPSACRNLFGPVNHEELTRDLEKHCRDMEEASQRKWNFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVPAQESQDVSGTRQAGPLLGSQANSEDTHLVDQKTDAPDSQTGLAEQCTGIRKRPATDDSSPQNKRANRTEENVSDGSPNAGSVEQTPKKPGLRRRQT

Target ORF information:

RefSeq Version	NM_001002957.2
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris cyclin dependent kinase inhibitor 1B (CDKN1B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001002957.2

ORF Insert Sequence:

ATGTCAAACG TGCGAGTGTC TAACGGGAGC CCGAGCCTCG AGCGGATGGA CGCCAGACAG 
GCCGAGTACC CCAAGCCCTC CGCCTGCAGG AACCTCTTCG GCCCGGTCAA CCACGAAGAG 
TTGACCCGGG ACTTGGAGAA GCACTGCAGA GACATGGAAG AGGCGAGCCA GCGCAAGTGG 
AATTTTGATT TCCAGAATCA CAAGCCCCTG GAGGGCAAAT ACGAGTGGCA GGAGGTGGAG 
AAGGGCAGCT TGCCCGAGTT CTACTACAGA CCCCCGCGGC CACCCAAAGG CGCCTGCAAG 
GTGCCGGCGC AGGAGAGCCA GGACGTCAGC GGGACCCGCC AGGCGGGGCC TTTACTGGGG 
TCTCAGGCCA ACTCAGAGGA CACACACTTG GTAGACCAAA AGACTGATGC GCCCGACAGC 
CAGACGGGGC TAGCGGAGCA GTGCACTGGG ATCAGGAAGC GACCCGCGAC CGACGATTCC 
TCTCCTCAAA ACAAAAGAGC CAACAGAACA GAAGAAAACG TCTCAGACGG TTCCCCGAAC 
GCGGGTTCAG TGGAGCAGAC GCCCAAGAAG CCGGGCCTCA GAAGACGTCA AACGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDKN1B ( XM_005636668.2 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_005636725.1 Canis lupus familiaris cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OCe26804
Clone ID Related Accession (Same CDS sequence)	XM_005636668.2 , XM_005636668.3 , NM_001002957.2
Accession Version	XM_005636668.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1442332800000
Organism	Canis lupus familiaris(Dog)
Product	cyclin-dependent kinase inhibitor 1B isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003726108.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 17, 2015 this sequence version replaced XM_005636668.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCAAACG TGCGAGTGTC TAACGGGAGC CCGAGCCTCG AGCGGATGGA CGCCAGACAG 
GCCGAGTACC CCAAGCCCTC CGCCTGCAGG AACCTCTTCG GCCCGGTCAA CCACGAAGAG 
TTGACCCGGG ACTTGGAGAA GCACTGCAGA GACATGGAAG AGGCGAGCCA GCGCAAGTGG 
AATTTTGATT TCCAGAATCA CAAGCCCCTG GAGGGCAAAT ACGAGTGGCA GGAGGTGGAG 
AAGGGCAGCT TGCCCGAGTT CTACTACAGA CCCCCGCGGC CACCCAAAGG CGCCTGCAAG 
GTGCCGGCGC AGGAGAGCCA GGACGTCAGC GGGACCCGCC AGGCGGGGCC TTTACTGGGG 
TCTCAGGCCA ACTCAGAGGA CACACACTTG GTAGACCAAA AGACTGATGC GCCCGACAGC 
CAGACGGGGC TAGCGGAGCA GTGCACTGGG ATCAGGAAGC GACCCGCGAC CGACGATTCC 
TCTCCTCAAA ACAAAAGAGC CAACAGAACA GAAGAAAACG TCTCAGACGG TTCCCCGAAC 
GCGGGTTCAG TGGAGCAGAC GCCCAAGAAG CCGGGCCTCA GAAGACGTCA AACGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005636725.1
CDS	640..1236
Translation	MSNVRVSNGSPSLERMDARQAEYPKPSACRNLFGPVNHEELTRDLEKHCRDMEEASQRKWNFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVPAQESQDVSGTRQAGPLLGSQANSEDTHLVDQKTDAPDSQTGLAEQCTGIRKRPATDDSSPQNKRANRTEENVSDGSPNAGSVEQTPKKPGLRRRQT

Target ORF information:

RefSeq Version	XM_005636668.2
Organism	Canis lupus familiaris(Dog)
Definition	Canis lupus familiaris cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005636668.2

ORF Insert Sequence:

ATGTCAAACG TGCGAGTGTC TAACGGGAGC CCGAGCCTCG AGCGGATGGA CGCCAGACAG 
GCCGAGTACC CCAAGCCCTC CGCCTGCAGG AACCTCTTCG GCCCGGTCAA CCACGAAGAG 
TTGACCCGGG ACTTGGAGAA GCACTGCAGA GACATGGAAG AGGCGAGCCA GCGCAAGTGG 
AATTTTGATT TCCAGAATCA CAAGCCCCTG GAGGGCAAAT ACGAGTGGCA GGAGGTGGAG 
AAGGGCAGCT TGCCCGAGTT CTACTACAGA CCCCCGCGGC CACCCAAAGG CGCCTGCAAG 
GTGCCGGCGC AGGAGAGCCA GGACGTCAGC GGGACCCGCC AGGCGGGGCC TTTACTGGGG 
TCTCAGGCCA ACTCAGAGGA CACACACTTG GTAGACCAAA AGACTGATGC GCCCGACAGC 
CAGACGGGGC TAGCGGAGCA GTGCACTGGG ATCAGGAAGC GACCCGCGAC CGACGATTCC 
TCTCCTCAAA ACAAAAGAGC CAACAGAACA GAAGAAAACG TCTCAGACGG TTCCCCGAAC 
GCGGGTTCAG TGGAGCAGAC GCCCAAGAAG CCGGGCCTCA GAAGACGTCA AACGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDKN1B ( XM_005636668.3 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_005636725.1 Canis lupus familiaris cyclin dependent kinase inhibitor 1B (CDKN1B), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OCe26804
Clone ID Related Accession (Same CDS sequence)	XM_005636668.2 , XM_005636668.3 , NM_001002957.2
Accession Version	XM_005636668.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1504454400000
Organism	Canis lupus familiaris(dog)
Product	cyclin-dependent kinase inhibitor 1B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006609.3) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 5, 2017 this sequence version replaced XM_005636668.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCAAACG TGCGAGTGTC TAACGGGAGC CCGAGCCTCG AGCGGATGGA CGCCAGACAG 
GCCGAGTACC CCAAGCCCTC CGCCTGCAGG AACCTCTTCG GCCCGGTCAA CCACGAAGAG 
TTGACCCGGG ACTTGGAGAA GCACTGCAGA GACATGGAAG AGGCGAGCCA GCGCAAGTGG 
AATTTTGATT TCCAGAATCA CAAGCCCCTG GAGGGCAAAT ACGAGTGGCA GGAGGTGGAG 
AAGGGCAGCT TGCCCGAGTT CTACTACAGA CCCCCGCGGC CACCCAAAGG CGCCTGCAAG 
GTGCCGGCGC AGGAGAGCCA GGACGTCAGC GGGACCCGCC AGGCGGGGCC TTTACTGGGG 
TCTCAGGCCA ACTCAGAGGA CACACACTTG GTAGACCAAA AGACTGATGC GCCCGACAGC 
CAGACGGGGC TAGCGGAGCA GTGCACTGGG ATCAGGAAGC GACCCGCGAC CGACGATTCC 
TCTCCTCAAA ACAAAAGAGC CAACAGAACA GAAGAAAACG TCTCAGACGG TTCCCCGAAC 
GCGGGTTCAG TGGAGCAGAC GCCCAAGAAG CCGGGCCTCA GAAGACGTCA AACGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005636725.1
CDS	653..1249
Translation	MSNVRVSNGSPSLERMDARQAEYPKPSACRNLFGPVNHEELTRDLEKHCRDMEEASQRKWNFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVPAQESQDVSGTRQAGPLLGSQANSEDTHLVDQKTDAPDSQTGLAEQCTGIRKRPATDDSSPQNKRANRTEENVSDGSPNAGSVEQTPKKPGLRRRQT

Target ORF information:

RefSeq Version	XM_005636668.3
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris cyclin dependent kinase inhibitor 1B (CDKN1B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005636668.3

ORF Insert Sequence:

ATGTCAAACG TGCGAGTGTC TAACGGGAGC CCGAGCCTCG AGCGGATGGA CGCCAGACAG 
GCCGAGTACC CCAAGCCCTC CGCCTGCAGG AACCTCTTCG GCCCGGTCAA CCACGAAGAG 
TTGACCCGGG ACTTGGAGAA GCACTGCAGA GACATGGAAG AGGCGAGCCA GCGCAAGTGG 
AATTTTGATT TCCAGAATCA CAAGCCCCTG GAGGGCAAAT ACGAGTGGCA GGAGGTGGAG 
AAGGGCAGCT TGCCCGAGTT CTACTACAGA CCCCCGCGGC CACCCAAAGG CGCCTGCAAG 
GTGCCGGCGC AGGAGAGCCA GGACGTCAGC GGGACCCGCC AGGCGGGGCC TTTACTGGGG 
TCTCAGGCCA ACTCAGAGGA CACACACTTG GTAGACCAAA AGACTGATGC GCCCGACAGC 
CAGACGGGGC TAGCGGAGCA GTGCACTGGG ATCAGGAAGC GACCCGCGAC CGACGATTCC 
TCTCCTCAAA ACAAAAGAGC CAACAGAACA GAAGAAAACG TCTCAGACGG TTCCCCGAAC 
GCGGGTTCAG TGGAGCAGAC GCCCAAGAAG CCGGGCCTCA GAAGACGTCA AACGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Serum starvation and thymidine double blocking achieved efficient cell cycle synchronization and altered the expression of p27, p53, bcl-2 in canine breast cancer cells.
Research in veterinary science10510-4(2016 Apr)
Tong J,Sun D,Yang C,Wang Y,Sun S,Li Q,Bao J,Liu Y

A novel mutation in the upstream open reading frame of the CDKN1B gene causes a MEN4 phenotype.
PLoS genetics9(3)e1003350(2013 Mar)
Occhi G,Regazzo D,Trivellin G,Boaretto F,Ciato D,Bobisse S,Ferasin S,Cetani F,Pardi E,Korbonits M,Pellegata NS,Sidarovich V,Quattrone A,Opocher G,Mantero F,Scaroni C

Serine 123 phosphorylation modulates p21 protein stability and activity by suppressing ubiquitin-independent proteasomal degradation.
The Journal of biological chemistry287(41)34410-8(2012 Oct)
Chen X,Zhang J,Zhang M,Liu S,Yan W,Jung J,Chen X

Expression of Ki-67, PCNA, and p27kip1 in canine pituitary corticotroph adenomas.
Domestic animal endocrinology38(4)244-52(2010 May)
van Rijn SJ,Grinwis GC,Penning LC,Meij BP

Differential expression of cell cycle regulators p21, p27 and p53 in metastasizing canine mammary adenocarcinomas versus normal mammary glands.
Research in veterinary science87(1)91-6(2009 Aug)
Klopfleisch R,Gruber AD

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CDKN1B cDNA ORF clone, Canis lupus familiaris(dog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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